Jürgen Knoblich
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German molecular biologist
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Molecular Biology
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Biology
Why Is Jürgen Knoblich Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jürgen Knoblich is a German molecular biologist. Since 2018, he is the interim Scientific Director of the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna. Education and career Knoblich studied Biochemistry at the University of Tübingen and Molecular Biology at University College London. In 1989 he transferred to the Max Planck Institute for Developmental Biology in Tübingen, where he completed his doctoral thesis in 1994 on the role of Cyclin proteins in controlling cell cycle progression during development. In 1994 he became a postdoctoral researcher at the University of California, San Francisco, where he worked with Dr. Yuh Nung Jan until 1997. Upon his return to Europe he joined the Institute of Molecular Pathology in Vienna, Austria as a group leader. In 2004, he moved to the newly founded Institute of Molecular Biotechnology in Vienna, where he was appointed deputy director in 2005 and became scientific director in 2018. Both the IMP and the IMBA are members of the Vienna Biocenter. Since 2021 he is chair in Synthetic Biology at Medical University of Vienna.
Jürgen Knoblich's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cerebral organoids model human brain development and microcephaly (2013) (3092)
- Organogenesis in a dish: Modeling development and disease using organoid technologies (2014) (1731)
- Generation of cerebral organoids from human pluripotent stem cells (2014) (954)
- Mechanisms of Asymmetric Stem Cell Division (2008) (949)
- Human cerebral organoids recapitulate gene expression programs of fetal neocortex development (2015) (761)
- Human organoids: model systems for human biology and medicine (2020) (699)
- The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl (2003) (598)
- Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation (1994) (580)
- Asymmetric cell division: recent developments and their implications for tumour biology (2010) (530)
- Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells (2006) (517)
- Asymmetric segregation of Numb and Prospero during cell division (1995) (500)
- Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates (2004) (496)
- Guided self-organization and cortical plate formation in human brain organoids (2017) (487)
- The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors (2009) (429)
- DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila (2000) (425)
- Role of inscuteable in orienting asymmetric cell divisions in Drosophila (1996) (410)
- Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. (2009) (403)
- The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. (2002) (393)
- Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts (1999) (392)
- Drosophila neuroblasts: a model for stem cell biology (2012) (383)
- The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. (2008) (377)
- Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization (2008) (363)
- Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. (2004) (351)
- A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila (2000) (347)
- Heterotrimeric G Proteins Direct Two Modes of Asymmetric Cell Division in the Drosophila Nervous System (2001) (342)
- The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. (1996) (334)
- Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System (2005) (332)
- Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi (2009) (320)
- The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. (2006) (310)
- Induction of Expansion and Folding in Human Cerebral Organoids. (2017) (287)
- Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis (2002) (284)
- Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain. (2016) (261)
- Proliferation control in neural stem and progenitor cells (2015) (260)
- The hope and the hype of organoid research (2017) (255)
- Self‐organized developmental patterning and differentiation in cerebral organoids (2017) (254)
- Fused cerebral organoids model interactions between brain regions (2017) (254)
- Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi (2011) (253)
- Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage (2008) (249)
- Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. (1995) (245)
- Safeguarding gene drive experiments in the laboratory (2015) (234)
- Synergistic action of Drosophila cyclins A and B during the G2‐M transition. (1993) (227)
- Genetically engineered cerebral organoids model brain tumour formation (2018) (222)
- Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. (2005) (209)
- Fused dorsal-ventral cerebral organoids model complex interactions between diverse brain regions (2017) (193)
- Human tissues in a dish: The research and ethical implications of organoid technology (2017) (190)
- Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division (2009) (186)
- Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. (1998) (184)
- Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (2006) (177)
- The Par Complex and Integrins Direct Asymmetric Cell Division in Adult Intestinal Stem Cells (2012) (168)
- Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells (2014) (168)
- Phosphorylation-Induced Autoinhibition Regulates the Cytoskeletal Protein Lethal (2) giant larvae (2005) (165)
- Mouse Inscuteable Induces Apical-Basal Spindle Orientation to Facilitate Intermediate Progenitor Generation in the Developing Neocortex (2011) (164)
- Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. (1998) (152)
- Spindle orientation in mammalian cerebral cortical development (2012) (143)
- Mammalian Inscuteable Regulates Spindle Orientation and Cell Fate in the Developing Retina (2005) (141)
- FACS Purification and Transcriptome Analysis of Drosophila Neural Stem Cells Reveals a Role for Klumpfuss in Self-Renewal (2012) (128)
- Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN (2014) (126)
- Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins (2005) (123)
- SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells (2014) (120)
- Shortstop Recruits EB1/APC1 and Promotes Microtubule Assembly at the Muscle-Tendon Junction (2003) (116)
- Mechanisms of asymmetric cell division during animal development. (1997) (112)
- The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. (2006) (111)
- The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization. (1997) (96)
- Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila (2001) (93)
- The PDZ Protein Canoe Regulates the Asymmetric Division of Drosophila Neuroblasts and Muscle Progenitors (2008) (88)
- Fragile X protein functions with lgl and the par complex in flies and mice. (2005) (87)
- LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (87)
- Broad applicability of a streamlined ethyl cinnamate-based clearing procedure (2018) (83)
- ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update (2021) (82)
- Heterotrimeric G Proteins New Tricks for an Old Dog (2004) (81)
- Spindle orientation and asymmetric cell fate (1995) (79)
- Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis (2020) (76)
- Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease (2020) (75)
- Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling (2008) (71)
- A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog (2014) (70)
- The Phosphatase PP4c Controls Spindle Orientation to Maintain Proliferative Symmetric Divisions in the Developing Neocortex (2013) (68)
- Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression. (1995) (68)
- Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. (2014) (67)
- Quantitative Analysis of Protein Dynamics during Asymmetric Cell Division (2005) (62)
- The Organoid Cell Atlas (2020) (62)
- Interaction of Activator of G-protein Signaling 3 (AGS3) with LKB1, a Serine/Threonine Kinase Involved in Cell Polarity and Cell Cycle Progression (2003) (62)
- Lethal giant larvae take on a life of their own. (2006) (61)
- Human organoids: a new dimension in cell biology (2019) (61)
- The tumor suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements (2011) (60)
- A human tissue screen identifies a regulator of ER secretion as a brain-size determinant (2020) (59)
- Endosome dynamics during development. (2006) (57)
- Identification of transcription factor binding sites from ChIP-seq data at high resolution (2013) (56)
- Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization (1999) (56)
- MicroRNA‐34/449 controls mitotic spindle orientation during mammalian cortex development (2016) (52)
- Long-Term Live Cell Imaging and Automated 4D Analysis of Drosophila Neuroblast Lineages (2013) (48)
- The E3‐ubiquitin ligase TRIM2 regulates neuronal polarization (2011) (45)
- Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC. (2015) (45)
- Transcriptome and proteome quantification of a tumor model provides novel insights into post‐transcriptional gene regulation (2013) (45)
- FACS purification of Drosophila larval neuroblasts for next-generation sequencing (2013) (45)
- Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation. (2018) (44)
- Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. (2021) (43)
- Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila. (2002) (35)
- Analysis and modeling of mitotic spindle orientations in three dimensions (2013) (32)
- Amplification of human interneuron progenitors promotes brain tumors and neurological defects (2022) (32)
- Pins for spines (2005) (31)
- Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding (2017) (31)
- Localization-Dependent and -Independent Roles of Numb Contribute to Cell-Fate Specification in Drosophila (2005) (30)
- The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda (2018) (29)
- The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells (2018) (29)
- Reflections on the past two decades of neuroscience (2020) (28)
- The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop (2019) (28)
- A nomenclature consensus for nervous system organoids and assembloids (2022) (24)
- Epithelial polarity: The ins and outs of the fly epidermis (2000) (22)
- The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. (2006) (22)
- Protein localization during asymmetric cell division. (2001) (19)
- The TRIM-NHL Protein Brat Promotes Axon Maintenance by Repressing src64B Expression (2014) (18)
- Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop (2018) (18)
- The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells (2017) (14)
- Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division. (2001) (14)
- Guided self-organization recapitulates tissue architecture in a bioengineered brain organoid model (2016) (11)
- The Conserved Discs-large Binding Partner Banderuola Regulates Asymmetric Cell Division in Drosophila (2014) (11)
- Faculty Opinions recommendation of The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. (2004) (10)
- Author Correction: Genetically engineered cerebral organoids model brain tumor formation (2018) (10)
- A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function (2016) (10)
- ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts (2021) (9)
- A Regulatory Transcriptional Loop Controls Proliferation and Differentiation in Drosophila Neural Stem Cells (2014) (9)
- Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids (2019) (9)
- Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors (2019) (8)
- Publisher Correction: Guided self-organization and cortical plate formation in human brain organoids (2018) (8)
- Cerebral organoid model reveals excessive proliferation of human caudal late interneuron progenitors in Tuberous Sclerosis Complex (2020) (8)
- Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations. (1997) (8)
- LIS1 and spindle orientation in neuroepithelial cells. (2008) (8)
- Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (7)
- Sara Splits the Signal (2006) (6)
- The Drosophila nervous system as a model for asymmetric cell division. (2001) (6)
- Wicked views on stem cell news (2009) (6)
- Cyclins and cdc2 kinases in Drosophila: genetic analyses in a higher eukaryote. (1992) (5)
- Fly Stem Cell Research Gets Infectious (2009) (5)
- Cell Biology: Notch Recycling Is Numbed (2013) (5)
- Tracing Stem Cell Division in Adult Neurogenesis. (2018) (4)
- Mentorship in Science: Response to AlShebli et al., Nature Communications 2020 (2021) (4)
- Fused dorsal-ventral cerebral organoids model human cortical interneuron migration (2017) (4)
- The HUSH complex controls brain architecture and protocadherin fidelity (2021) (3)
- A Human Accelerated Region participates in early human forebrain patterning and expansion (2019) (3)
- Author response: The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells (2018) (3)
- Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease (2020) (3)
- Lab-Built Brains. (2016) (3)
- Neurobiology: Getting axons going (2005) (2)
- Neutral competition within a long-lived population of symmetrically dividing cells shapes the clonal composition of cerebral organoids (2021) (2)
- CHAPTER 214 – Genetic Analysis of Heterotrimeric G-Protein Function (2003) (1)
- Genetically engineered cerebral organoids model brain tumor formation (2018) (1)
- Prospero Phase-Separating the Way to Neuronal Differentiation. (2020) (1)
- A48 Expanded HTT cag repeats disrupt the balance between neural progenitor expansion and differentiation in isogenic human cerebral organoids (2018) (1)
- Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous ECM (2022) (1)
- Purification of Drosophila protein complexes for mass spectrometry. (2008) (1)
- Cell division, growth and death. (2008) (1)
- Cell biology. Sara splits the signal. (2006) (1)
- Detailed Cerebral Organoid Fusion Method (2017) (1)
- LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (1)
- Genetic engineering to initiate tumorigenesis in cerebral organoids (2018) (1)
- Asymmetric cell division and spindle orientation in neural stem cells - from drosophila to humans (2013) (1)
- Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders (2023) (0)
- S07-02 Asymmetric cell division and proliferation control in Drosophila and mouse neural stem cells (2009) (0)
- Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (0)
- Induction of Expansion an d Folding in Human Cerebral Organoids Graphical (0)
- Author Correction: Genetically engineered cerebral organoids model brain tumor formation (2018) (0)
- Chromatin preparation and ChIP from Drosophila brain and discs tissues (2011) (0)
- Faculty Opinions recommendation of The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein. (2002) (0)
- Modeling Human Brain Development And Disease In Stem Cell Derived 3D Organoid Culture (2017) (0)
- Faculty Opinions recommendation of Oriented cell divisions asymmetrically segregate aPKC and generate cell fate diversity in the early Xenopus embryo. (2003) (0)
- The orientation of asymmetric cell divisions directs lineage decisions in the mouse neocortex (2012) (0)
- 02-P011 Identification of new cell growth regulators in Drosophila melanogaster by genome wide RNAi screening (2009) (0)
- On the backroads to cellular asymmetry (2007) (0)
- DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations in Drosophila melanogaster. (2020) (0)
- ARID1B controls transcriptional programs of axon projection in the human corpus callosum (2023) (0)
- Lab-built brains. (Cover story) (2017) (0)
- Tumor organoid model (2018) (0)
- Correction (2021) (0)
- Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids (2023) (0)
- You Are What You Eat: Linking Metabolic Asymmetry and Cell Fate Choice. (2016) (0)
- Document S1. Figures S1–S5 and Supplemental Experimental Procedures (2013) (0)
- Integrated transcriptome and proteome analysis in human brain organoids reveals posttranscriptional regulation of ribosomal genes (2022) (0)
- Faculty Opinions recommendation of Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity. (2006) (0)
- Erratum to Wolfgang Benetka et al., Cell Cycle Volume 7, Issue 23; pp. 3709-3719 (2009) (0)
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What Schools Are Affiliated With Jürgen Knoblich?
Jürgen Knoblich is affiliated with the following schools:
