K. Birgitta Whaley
American professor of chemistry
K. Birgitta Whaley's AcademicInfluence.com Rankings
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Chemistry
K. Birgitta Whaley's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is K. Birgitta Whaley Influential?
(Suggest an Edit or Addition)According to Wikipedia, Katherine Birgitta Whaley is a professor of chemistry at the University of California Berkeley and a senior faculty scientist in the Division of Chemical Sciences at Lawrence Berkeley National Laboratory. At UC Berkeley, Whaley is the director of the Berkeley Quantum Information and Computation Center, a member of the executive board for the Center for Quantum Coherent Science, and a member of the Kavli Energy Nanosciences Institute. At Lawrence Berkeley National Laboratory, Whaley is a member of the Quantum Algorithms Team for Chemical Sciences in the research area of resource-efficient algorithms.
K. Birgitta Whaley's Published Works
Published Works
- Modulation of the alternative complement pathways by beta 1 H globulin (1976) (496)
- Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes (1980) (342)
- Episcleritis and scleritis. A study of their clinical manifestations and association with rheumatoid arthritis. (1976) (177)
- Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils. (1997) (159)
- Modulation of C3b hemolytic activity by a plasma protein distinct from C3b inactivator. (1976) (139)
- MODULATION OF THE ALTERNATIVE COMPLEMENT PATHWAY BY fllH GLOBULIN (1976) (138)
- Sjogren's syndrome. 2. Clinical associations and immunological phenomena. (1973) (135)
- Liver disease in rheumatoid arthritis and Sjøgren's syndrome. Prospective study using biochemical and serological markers of hepatic dysfunction. (1975) (98)
- Liver disease in Sjögren's syndrome and rheumatoid arthritis. (1970) (92)
- Endotoxaemia and complement activation in acute pancreatitis in man. (1982) (88)
- Histology of the lacrimal gland in keratoconjunctivitis sicca. (1973) (81)
- Sjøgren's SyndromeI. SICCA COMPONENTS (1973) (80)
- Effect of interferon-gamma on complement gene expression in different cell types. (1992) (77)
- Complement and complement deficiencies. (1997) (76)
- Sjögren's syndrome and autoimmunity in a geriatric population. (1972) (75)
- Otolaryngological Aspects of Sjögren's Syndrome (1971) (74)
- Synthesis of classical pathway complement components by chondrocytes. (1996) (69)
- Increased biosynthesis of complement components by cultured monocytes, synovial fluid macrophages and skynovial membrane cells from patients with rheumatoid arthritis. (1980) (66)
- Antinuclear antibodies in psychiatric illness: their relationship to diagnosis and drug treatment. (1975) (63)
- Autoantibody facilitated cleavage of C1-inhibitor in autoimmune angioedema. (1989) (59)
- Complement-subcomponent-C1-inhibitor synthesis by human monocytes. (1985) (55)
- A statistical aid to the diagnosis of keratoconjunctivitis sicca. (1972) (54)
- Sjogren's syndrome. I. Sicca components. (1973) (54)
- Modulation of monocyte complement synthesis by interferons. (1987) (51)
- Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synovium (2004) (48)
- Interferon-induced transcriptional and post-transcriptional modulation of factor H and C4 binding-protein synthesis in human monocytes. (1990) (46)
- Complement biosynthesis by mononuclear phagocytes (1993) (46)
- Adrenergic receptors on monocytes modulate complement component synthesis. (1982) (45)
- Epitope mapping of C1 inhibitor autoantibodies from patients with acquired C1 inhibitor deficiency. (1996) (45)
- Adenosine A2 receptors on human monocytes modulate C2 production. (1984) (45)
- Decreased C3b receptors (CR1) on erythrocytes from patients with systemic lupus erythematosus. (1986) (44)
- Regulation of the synthesis of C1 subcomponents and C1-inhibitor. (1993) (43)
- Precipitating antibodies to cellular antigens in Sjögren's syndrome, rheumatoid arthritis, and other organ and nonorgan-specific autoimmune diseases. (1978) (43)
- Salivary duct autoantibody in Sjøgren's syndrome: correlation with focal sialadenitis in the labial mucosa (1969) (40)
- An examination of the immunology of cancer patients (1976) (39)
- Human complement factor H. Tissue specificity in the expression of three different mRNA species. (1991) (39)
- Modulation by interferons of the expression of monocyte complement genes. (1990) (39)
- Measurement of joint inflammation. A radioisotopic method. (1970) (39)
- C2 synthesis by human monocytes is modulated by a nicotinic cholinergic receptor (1981) (37)
- Methods in complement for clinical immunologists (1985) (36)
- Decreased Total Numbers of Peripheral Blood Lymphocytes with Elevated Percentages of CD4+CD45RO+ and CD4+CD25+ of T‐Helper Cells in Non‐Segmental Vitiligo (2002) (36)
- The articular scan in patients with rheumatoid arthritis: a possible method of quantitating joint inflammation using radio-technetium. (1968) (35)
- Hydrostatic Sialography as an Index of Salivary Gland Disease in Sjögren's Syndrome (1971) (34)
- Modulation of complement gene expression by glucocorticoids. (1991) (34)
- Interferon-mediated transcriptional and post-transcriptional modulation of complement gene expression in human monocytes. (1990) (33)
- Clinical studies on inflammation in human knee joints: xenon (133Xe) clearances correlated with clinical assessment in various arthritides and studies on the effect of intra-articularly administered hydrocortisone in rheumatoid arthritis. (1970) (33)
- Thymoma‐associated cutaneous graft‐versus‐host‐like reaction (1997) (32)
- Complement activation in chronic liver disease. (1982) (32)
- Sjögren's Syndrome (1972) (31)
- Immunological responses in Sjogren's syndrome and rheumatoid arthritis. (1971) (30)
- Complement biosynthesis in human synovial tissue. (1989) (30)
- Requirements for beta1H globulin and C3b inactivator in the control of the alternative complement pathway in human serum. (1978) (30)
- Expression of the components and regulatory proteins of the classical pathway of complement in normal and diseased synovium (2004) (29)
- Effects of histamine on monocyte complement production. I. Inhibition of C2 production mediated by its action on H2 receptors. (1980) (29)
- C3b receptor (CR1) expression on the polymorphonuclear leukocytes from patients with systemic lupus erythematosus. (1987) (28)
- C3b inactivator in the rheumatic diseases. Measurement by radial immunodiffusion and by inhibition of formation of properdin pathway C3 convertase. (1976) (26)
- Sialographic abnormalities in Sjogren's syndrome, rheumatoid arthritis, and other arthritides and connective tissue diseases. A clinical and radiological investigation using hydrostatic sialography. (1972) (26)
- Derivation of knee joint synovial perfusion. Using the Xenon (133Xe) clearance technique. (1970) (26)
- Complement-mediated inhibition of immune precipitation in patients with immune complex diseases. (1983) (25)
- Diagnostic value of quantitative scintiscanning of the salivary glands in Sjögren's syndrome and rheumatoid arthritis. (1971) (25)
- Immune complexes in Sjögren's syndrome. (1980) (25)
- Sjögren's syndrome in relation to pernicious anaemia and idiopathic Addison's disease. (1970) (24)
- IgM-RF prevents complement-mediated inhibition of immune precipitation. (1984) (24)
- Autoimmune C1‐inhibitor deficiency (1996) (24)
- Systemic lupus erythematosus complicating hyper IgE syndrome. (1997) (24)
- Complement in Health and Disease (2012) (24)
- Monocyte C1‐inhibitor synthesis in patients with C1‐inhibitor deficiency (1989) (23)
- Studies on the sympathetic control of normal and diseased synovial blood vessels: the effect of alpha and beta receptor stimulation and inhibition, monitored by the 133xenon clearance technique. (1971) (23)
- Complement and immune complex diseases. (1986) (22)
- Prevention of immune precipitation by purified classical pathway complement components. (1984) (22)
- Prostaglandins and prostaglandin synthetase inhibitors regulate the synthesis of complement components by human monocytes. (1982) (22)
- Synthesis of complement components (C3, C2, B and C1-inhibitor) and lysozyme by human monocytes and macrophages. (1986) (21)
- Cyclic nucleotides and their relationship to complement-component-C2 synthesis by human monocytes. (1984) (21)
- The effects of immunoglobulin isotype and antibody affinity on complement-mediated inhibition of immune precipitation and solubilization. (1987) (21)
- Clinical trial of pentazocine in rheumatoid arthritis. Observations on the value of potent analgesics and placebos. (1973) (21)
- Molecular aspects of complement activation (1981) (21)
- Synthesis of complement components by synovial membrane. (1992) (21)
- Mechanism of Action of Anti-C1-Inhibitor Autoantibodies: Prevention of the Formation of Stable C1s-C1-inh Complexes (1998) (20)
- Some aspects in the quantitation of inflammation in joints of patients suffering from rheumatoid arthritis. (1970) (20)
- A secondary C1s interaction site on C1‐inhibitor is essential for formation of a stable enzyme‐inhibitor complex (1997) (20)
- Familial properdin deficiency associated with chronic discoid lupus erythematosus. (1989) (20)
- Alternative pathway complement activation in rheumatoid arthritis. (1980) (20)
- Relative importance of C3b inactivator and beta 1H globulin in the modulation of the properdin amplification loop in systemic lupus erythematosus. (1979) (20)
- Biosynthesis of complement components. (1982) (19)
- Sjögren's syndrome in psoriatic arthritis, ankylosing spondylitis and Reiter's syndrome. (1971) (19)
- Lymphocytic sialadenitis in the buccal mucosa, in Sjögren's disease, rheumatoid arthritis and other arthritides. A clinical and laboratory study. (1968) (19)
- The complement system in sepsis and trauma. (1985) (18)
- Complement metabolism in the seronegative arthritides. (1974) (18)
- Regulation of hepatic synthesis of C3 and C4 during the acute‐phase response in the rat (1989) (17)
- Control of complement activation in membranous and membranoproliferative glomerulonephritis. (1980) (17)
- Circulating immune complexes associated with decreased complement-mediated inhibition of immune precipitation in sera from patients with bacterial endocarditis. (1986) (17)
- Effect of histamine on monocyte complement production. II. Modulation of protein secretion, degradation and synthesis. (1980) (16)
- Penicillin allergy in rheumatoid arthritis. With special reference to Sjogren's syndrome. (1969) (16)
- Regulation of C1-inhibitor synthesis by interferons and other agents. (1989) (15)
- A single base deletion from the C1-inhibitor gene causes type I hereditary angio-oedema. (1992) (15)
- Radioisotope study of small joint inflammation in rheumatoid arthritis. (1971) (15)
- Regional assignment of the human C1-inhibitor gene to 11q11–q13.1 (1990) (15)
- Fatal Subaxial Dislocation of Cervical Spine in Rheumatoid Arthritis (1968) (15)
- Control of immune complexes by the classical pathway. (1989) (14)
- Prevention of immune precipitation by purified components of the alternative pathway. (1985) (14)
- Autoantibodies in childhood connective tissue diseases and in normal children. (1975) (14)
- Purification of a plasma protein that inhibits complement-mediated prevention of immune precipitation. (1988) (13)
- A point mutation in the C1-inhibitor gene causes type I hereditary angiooedema. (1993) (13)
- Type II hereditary angio-oedema associated with two mutations in one allele of the C1-inhibitor gene around the reactive-site coding region. (1992) (13)
- Quantitation of human C4A and C4B, in serum and plasma by enzyme-linked immunoadsorbent assay (2004) (13)
- Biosynthesis of complement components by cultured rat hepatocytes. (1985) (12)
- Restriction fragment length polymorphism analysis of the C1‐inhibitor gene in hereditary C1‐inhibitor deficiency (1991) (12)
- Measurement of complement activation in clinical practice. (1989) (12)
- Clinical Significance of Native DNA Antibodies in Systemic Lupus Erythematosus and other Connective Tissue Diseases (1974) (12)
- Experimental induction of immune sialadenitis in guinea-pigs using different adjuvants. (1974) (12)
- Role of the distal hinge region of C1‐inhibitor in the regulation of C1s activity (1997) (12)
- Inhibition of complement-mediated solubilization of antigen-antibody complexes by sera from patients with rheumatoid arthritis. (1983) (12)
- The activation of C3 and C4 in human serum by immune complexes containing mouse monoclonal antibodies of different isotype and affinity: effects on solubilisation. (1988) (12)
- The effect of antibody isotype on the activation of C3 and C4 by immune complexes formed in the presence of serum: correlation with the prevention of immune precipitation. (1990) (11)
- EVALUATION OF THE NATIVE DNA‐BINDING ASSAY FOR DNA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER CONNECTIVE TISSUE DISEASES (1974) (10)
- Effect of Anti-inflammatory Drug Therapy on Clearance of 133Xe from Knee Joints of Patients with Rheumatoid Arthritis (1969) (10)
- Mechanism of action of an inhibitor of complement-mediated prevention of immune precipitation. (1990) (10)
- The sequence of a cDNA encoding functional murine C1-inhibitor protein. (1997) (10)
- Cyclic AMP-mediated modulation of the production of the second component of human complement by monocytes. (1981) (10)
- THE INTERACTION BETWEEN HUMAN SERUM AMYLOID P COMPONENT [SAP] AND FIXED COMPLEMENT (1982) (10)
- Studies of the action of some anti-inflammatory drugs on complement mediated immune haemolysis. (1975) (9)
- Sjogren's syndrome: its clinical manifestations and associations. (1972) (9)
- Measurement of complement activation products in patients with chronic rheumatic diseases (2005) (9)
- Complement, antigen-antibody complexes and immune complex disease. (1985) (9)
- Hereditary Angio-Oedema: Its Pathogenesis and Management (1980) (8)
- Dissociation of primary antigen-antibody bonds is essential for complement mediated solubilization of immune precipitates. (1992) (8)
- Characterisation of nucleotide sequence variants and disease-specific mutations involving the 3' end of the C1-inhibitor gene in hereditary angio-oedema. (1995) (8)
- The plasma protein which inhibits complement-mediated prevention of immune precipitation is an Fc binding protein. (1989) (8)
- Effect of synovectomy on the clearance of radioactive xenon (133Xe) from the knee joint of patients with rheumatoid arthritis. (1970) (8)
- Immunohistochemical localization of a plasma protein (glycoprotein 60) which inhibits complement-mediated prevention of immune precipitation. (1990) (8)
- In vitro studies on the phagocytosis of Staphylococcus aureus by peritoneal macrophages of New Zealand mice. (1973) (7)
- Computer-assisted diagnosis in keratoconjunctivitis sicca. (1971) (7)
- Enhancement of monocyte complement component synthesis by antigen--antibody complexes. (1981) (7)
- Evaluation of the C1q solid-phase binding assay for immune complexes. A clinical and laboratory study. (1979) (7)
- Effect of Glyvenol (CIBA) on pain and on capillary resistance in rheumatoid arthritis. (1969) (7)
- Recent advances in Sjogren's syndrome. (1971) (7)
- Modulation of monocyte complement synthesis by lymphocytes and lymphocyte-conditioned media. (1989) (7)
- Serum-treated antigen-antibody complexes inhibit the production of C2 and factor B by mononuclear phagocytes. (1983) (6)
- Modulation of the alternative complement pathway in patients with Gram‐negative bacteraemia (1980) (6)
- Modulation of the properdin amplification loop in membranoproliferative and other forms of glomerulonephritis. (1979) (6)
- Purification and characterization of RHP (factor H) and study of its interactions with the first component of complement. (1992) (6)
- Complement levels in serum and bile in patients with extra-hepatic biliary tract obstruction. (1984) (5)
- An RNA splice site mutation in the C1-inhibitor gene causes type I hereditary angio-oedema (1991) (5)
- The relative roles of C4A and C4B in prevention of immune precipitation, solubilisation and immune adherence (2004) (5)
- The lysine-vasopressin test: an evaluation of two methods of administration in non-corticosteroid-treated and corticosteroid-treated patients with rheumatoid arthritis. (1970) (5)
- Phagocytosis inhibits the production of C2 by human monocytes. (1983) (5)
- A comparison of the effects of heat-aggregated and chemically cross-linked IgG on monocyte C2 production. (1983) (5)
- C3bINA Accelerator: A Serum Cofactor for C3b Inactivator Necessary for the Full Expression of Its Activity (1976) (5)
- Role of C3 in the control of monocyte C2 production. (1984) (5)
- Sjögren's syndrome. (1972) (5)
- Anaphylatoxins inhibit C2 production. (1983) (4)
- Evidence for glomerular modulation of complement activation. (1979) (4)
- Clinical Trial of Lincomycin Hydrochloride in Reiter's Disease (1969) (4)
- Cyclic AMP mediated modulation of complement protein production. (1982) (4)
- Antimycobacterial hsp65 and rheumatoid factor titres in a population of normal twins: evidence of genetic control of rheumatoid factor (1995) (4)
- Modulation of C2 biosynthesis by antigen-antibody complexes. (1982) (4)
- The Clinical Significance of the Antinuclear Antibody Test as a Screening Procedure for DNA Antibodies in SLE (1980) (4)
- Measurement of synovial blood flow in normal and diseased joints. (1969) (4)
- The relative roles of genetic and environmental factors in the regulation of erythrocyte C3b receptor (ECR1) numbers in normal individuals. (1987) (4)
- Cellular immune mechanisms in rheumatoid arthritis and Sjögren's syndrome. (1971) (3)
- Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase. (1993) (3)
- Phagocytosis of Colloidal Carbon by the Fixed Tissue and Peritoneal Macrophages of New Zealand Mice (1972) (3)
- The role of ion channels and protein kinase C activation in the stimulation of complement protein synthesis. (1987) (3)
- Synthesis and secretion of complement components by mononuclear phagocytes (1985) (3)
- The complement system and inflammation (1995) (3)
- Complement and related clinical disorders. (1989) (3)
- Therapeutic Immunosuppression (2001) (3)
- Articular scan in patients with rheumatoid arthritis: a possible method of quantitating joint inflammation usine radio-technetium. (1969) (3)
- Clinical aspects of auto-immunity. (1969) (3)
- Adaptation of Enzyme Labelled Immunoassay (ELISA) for Measurement of Biosynthesis of Human and Rat Complement Components (1988) (3)
- Conjugal prevalence of rheumatoid arthritis, rheumatoid factor and other autoantibodies in rheumatoid arthritis. (1968) (3)
- Regional chromosomal assignment of genes encoding the α and β subunits of human complement protein C8 to 1p32 (1992) (3)
- Requirement for cations in the stimulation of C2 synthesis by human monocytes. (1985) (3)
- Clinico-pharmacological studies on depot tetracosactrin in patients with rheumatoid arthritis (1970) (2)
- Control of monocyte C2 production by cyclic AMP. (1983) (2)
- Comparison of the Adrenocorticotrophic Activities of Two Synthetic Polypeptides: Synacthen and DW 75* (1968) (2)
- Complement deficiency syndromes and bacterial infections. (1983) (2)
- C1-inhibitor synthesis by monocytes of patients with C1-inhibitor deficiency (1987) (2)
- Liver palms in rheumatoid arthritis. (1969) (2)
- Complement and the Mononuclear Phagocyte System (1993) (2)
- Follow-up studies on synovectomy of the knee in rheumatoid arthritis. (1970) (2)
- Synovectomy of the knee in rheumatoid arthritis: critical appraisal based on a long-term follow-up of 145 patients. (1973) (1)
- Effect of interferon-y on complement gene expression in different cell types (2005) (1)
- Immunohistochemical and functional studies of glycoprotein 60 (gp60) in platelets (2004) (1)
- Conjugal prevalence of rheumatoid arthritis, rheumatoid factor, and other autoantibodies in rheumatoid arthritis. (1969) (1)
- Sympathetic control of synovial blood vessels. (1970) (1)
- Hypocomplementaemia and Disease (1978) (1)
- The incidence of antinuclear antibodies in relation to drug therapy in psychiatric patients [proceedings]. (1975) (1)
- Assessment of a test of adrenocortical function using beta1-25 corticotrophin. (1969) (1)
- Use of antisera to the isolated alpha and beta subunits of C3 as probes to study functional sites present on particle-bound C3b but absent on native soluble forms of C3. (1988) (1)
- Inhibition of C1q binding to antigen-antibody complexes by a factor in rheumatoid arthritis serum (2004) (1)
- The effect of isoprenaline and noradrenaline on an indirect measure of synovial blood flow in dogs. (1970) (1)
- Comparative study of endralazine and hydralazine for the treatment of hypertension uncontrolled by a beta-blocker and diuretic. (1986) (1)
- Aspects ofSjogren's Syndrome (1971) (1)
- KpnI RFLP in the 3' flanking region of the C1 inhibitor gene. (1989) (1)
- Immunological Mechanisms in the Pathogenesis of Systemic Lupus Erythematosus (1970) (1)
- An inhibitor of complement-mediated prevention of immune precipitation in rheumatoid arthritis — relationship to disease activity and systemic manifestations (2004) (1)
- C1-inhibitor gene nucleotide insertion causes type II hereditary angio-oedema (1993) (1)
- Regional chromosomal assignment of genes encoding the alpha and beta subunits of human complement protein C8 to 1p32. (1992) (1)
- Book Review: New Books: Diagnostic Immunology and Serology: A Clinician's Guide (1980) (0)
- Liver disease inrheumatoid arthritis and Sj0gren's syndrome Prospective studyusing biochemical andserological markers ofhepatic dysfunction (1975) (0)
- Theplasmaprotein whichinhibits complement-mediated prevention ofimmuneprecipitation isan Fcbinding protein (1989) (0)
- Histology ofthelacrimal glandin keratoconjunctiv itis (1972) (0)
- Acquired C1 esterase inhibitor deficiency (1988) (0)
- Observations on the clinical outcome and recovery of hypothalamo-pituitary-adrenal axis function after complete withdrawal of long-term corticosteroid therapy in patients with rheumatoid arthritis. (1970) (0)
- Clearance of dna from blood in new zealand mice (1972) (0)
- Clinical Approach to Immunotoxicology and Autoimmunity (1997) (0)
- Anti Mycobacterial HSP 65 and Rheumatoid Factor Titres in a Population of Normal Twins (1994) (0)
- Proceedings: Antigen catabolism in New Zealand and other strains of mice. (1974) (0)
- Nicotinic cholinergic receptors on human and guinea pig mononuclear phagocytes modulate C2 synthesis (1982) (0)
- Synthesis ofclassical pathwaycomplement componentsbychondrocytes (1996) (0)
- [Sjögren's syndrome (detailed description)]. (1976) (0)
- Immunological studies of the connective tissue diseases using New Zealand mice as a laboratory model (1973) (0)
- Cancer Immunology (2001) (0)
- Observations on thevalue ofpotentanalgesics andplacebos (1973) (0)
- Clearance of deoxyribonucleic acid from blood in New Zealand mice. (1972) (0)
- AbstractModulation of C2 and factor B(B) synthesis by Fc and C3b receptors (1982) (0)
- Studies on thyroid function in the mouse: interstrain differences in thyroxine secretion rates and organ content of thyroxine. (1973) (0)
- Recent Developments in Prophylactic Immunization (2011) (0)
- Monocyte C1‐inhibitor synthesis in patients with C1‐inhibitor deficiency (1989) (0)
- Modulation of classifical pathway complement activation in rheumatic diseases (1984) (0)
- Immunobiology of the Complement System: An Introduction for Research and Clinical Medicine (1987) (0)
- Catabolism of bovine gamma globulin in New Zealand mice. (1972) (0)
- Book Review / News Item (1983) (0)
- Laboratory investigation of immunodeficiency and autoimmunity in humans (1995) (0)
- A simple technique for measuring thyroxine secretion rate in the mouse. (1973) (0)
- Effect of anti-inflammatory drug therapy on clearance of 133-Xe from knee joints of patients with rheumatoid arthritis. (1969) (0)
- Inhibition of immune precipitation in rheumatic disease. A clinical and laboratory study. (1984) (0)
- Rheumatic Diseases Table I Clinicalfeatures of patients studied Sex Clinical group Ankylosing spondylitis Reiter ' s disease Still ' s disease Psoriatic arthritis (0)
- Assessment of clinical methods of evaluation and isotope techniques in analgesic trials in rheumatoid arthritis. (1970) (0)
- Inhibition of complement-mediated solubilisation of antigen-antibody complexes by serum factor(s) in patients with various connective tissue diseases. (1986) (0)
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