Kenan Christopher Garcia
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Physics Biology
Kenan Christopher Garcia's Degrees
- PhD Biophysics University of California, Berkeley
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(Suggest an Edit or Addition)Kenan Christopher Garcia's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex (1996) (1145)
- Do 15-Month-Old Infants Understand False Beliefs ? (2005) (1133)
- Accurate prediction of protein structures and interactions using a 3-track neural network (2021) (1055)
- STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1 (2009) (893)
- Activation and allosteric modulation of a muscarinic acetylcholine receptor (2013) (773)
- Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. (1998) (729)
- Structural Basis of Wnt Recognition by Frizzled (2012) (726)
- Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis (2009) (660)
- Structural basis of T cell recognition. (1999) (560)
- Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells (2018) (466)
- Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex (2003) (458)
- Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis (2009) (455)
- Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System (2008) (447)
- Deconstructing the Peptide-MHC Specificity of T Cell Recognition (2014) (431)
- Mutational signature in colorectal cancer caused by genotoxic pks+E. coli (2020) (426)
- Screening and large-scale expression of membrane proteins in mammalian cells for structural studies (2014) (425)
- Exploiting a natural conformational switch to engineer an Interleukin-2 superkine (2012) (399)
- The composition and signaling of the IL-35 receptor are unconventional (2012) (372)
- Adrenaline-activated structure of the β2-adrenoceptor stabilized by an engineered nanobody (2013) (368)
- Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies (2013) (365)
- CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes (1996) (358)
- Structural biology of shared cytokine receptors. (2009) (342)
- Human LilrB2 Is a β-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s Model (2013) (330)
- The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1. (2000) (327)
- Two-step binding mechanism for T-cell receptor recognition of peptide–MHC (2002) (312)
- Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons (2011) (308)
- Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal (2017) (294)
- Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75 (2004) (293)
- Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. (2005) (291)
- Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors (2007) (290)
- Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γc Receptors (2005) (282)
- A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. (2000) (279)
- How a Single T Cell Receptor Recognizes Both Self and Foreign MHC (2007) (265)
- De novo design of potent and selective mimics of IL-2 and IL-15 (2019) (261)
- CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. (2016) (259)
- In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles (2019) (257)
- Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. (2003) (257)
- Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex (2001) (248)
- Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon' (2007) (241)
- A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. (2000) (241)
- T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. (2011) (239)
- Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor (2014) (237)
- Durable antitumor responses to CD47 blockade require adaptive immune stimulation (2016) (237)
- Mutations in WNT1 cause different forms of bone fragility. (2013) (235)
- The molecular basis of TCR germline bias for MHC is surprisingly simple (2009) (233)
- Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. (2003) (231)
- Deconstructing the form and function of the TCR/CD3 complex. (2006) (224)
- Structure of a γδ T Cell Receptor in Complex with the Nonclassical MHC T22 (2005) (217)
- Structure of the Nogo Receptor Ectodomain A Recognition Module Implicated in Myelin Inhibition (2003) (205)
- Polyspecificity of T cell and B cell receptor recognition. (2007) (205)
- Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes (2017) (203)
- Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer (2017) (203)
- Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes (2018) (199)
- Structural basis for Notch1 engagement of Delta-like 4 (2015) (199)
- Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity (2017) (198)
- A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors (2005) (198)
- Structural basis of receptor sharing by interleukin 17 cytokines (2009) (193)
- The Structure of Interleukin-2 Complexed with Its Alpha Receptor (2005) (193)
- Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation (2012) (191)
- Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling (2017) (190)
- Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein (2014) (189)
- Progenitor identification and SARS-CoV-2 infection in human distal lung organoids (2020) (186)
- Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. (2005) (183)
- Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes. (1998) (180)
- An Extracellular Interactome of Immunoglobulin and LRR Proteins Reveals Receptor-Ligand Networks (2013) (180)
- Alanine Scanning Mutagenesis of an αβ T Cell Receptor: Mapping the Energy of Antigen Recognition (1998) (176)
- Graded Expression of Semaphorin-1a Cell-Autonomously Directs Dendritic Targeting of Olfactory Projection Neurons (2007) (173)
- Antigen Recognition Determinants of γδ T Cell Receptors (2005) (172)
- Insights into cytokine-receptor interactions from cytokine engineering. (2015) (171)
- Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding (2018) (170)
- Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy (2018) (163)
- How the T Cell Receptor Sees Antigen—A Structural View (2005) (161)
- Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. (2005) (161)
- Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. (1997) (157)
- STIM 1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai 1 (2009) (155)
- Structural energetics of peptide recognition: Angiotensin II/antibody binding (1993) (152)
- Three-dimensional structure of an angiotensin II-Fab complex at 3 A: hormone recognition by an anti-idiotypic antibody. (1992) (152)
- Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. (2014) (151)
- Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily (2002) (143)
- Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2 (2013) (138)
- Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (2003) (133)
- Specificity and degeneracy of T cells. (2004) (132)
- Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1 (2010) (130)
- Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. (2015) (126)
- A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism (2018) (125)
- Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor (2005) (123)
- Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling (2017) (122)
- The Vα14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex1 (2002) (121)
- Genetic variation in MHC proteins is associated with T cell receptor expression biases (2016) (120)
- Structure of the measles virus hemagglutinin (2007) (118)
- BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies. (2008) (118)
- Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain (2008) (118)
- Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands (2015) (118)
- Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins (2015) (115)
- Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. (2015) (115)
- Opposing T Cell Responses in Experimental Autoimmune Encephalomyelitis (2019) (112)
- Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. (2010) (112)
- Molecular architecture of the αβ T cell receptor–CD3 complex (2014) (111)
- Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. (2002) (110)
- The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. (2008) (110)
- Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes (2002) (109)
- Kinetics and thermodynamics of T cell receptor– autoantigen interactions in murine experimental autoimmune encephalomyelitis (2001) (109)
- Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. (2005) (108)
- Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15 (2012) (106)
- Structural Insight into Pre-B Cell Receptor Function (2007) (106)
- Molecular and structural insight into proNGF engagement of p75NTR and sortilin. (2010) (105)
- Data publication with the structural biology data grid supports live analysis (2016) (103)
- Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes (2016) (100)
- Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches (2011) (97)
- Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. (2004) (97)
- Structure of the activating IL-1 receptor signaling complex (2012) (94)
- Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. (2008) (93)
- Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules (1996) (90)
- Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors (2007) (86)
- Localized CD47 blockade enhances immunotherapy for murine melanoma (2017) (84)
- Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (2006) (83)
- Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation (2017) (82)
- Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance (2018) (81)
- Simplified, Enhanced Protein Purification Using an Inducible, Autoprocessing Enzyme Tag (2009) (80)
- Antigen recognition determinants of gammadelta T cell receptors. (2005) (79)
- Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations (2020) (79)
- Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. (2011) (76)
- Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes. (2020) (76)
- Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines (2012) (75)
- Evidence for a functional sidedness to the αβTCR (2010) (74)
- Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors. (2004) (74)
- An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells (2008) (73)
- Shared cytokine signaling receptors: structural insights from the gp130 system. (2004) (72)
- Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition. (1998) (71)
- Mechanistic and structural insights into the proteolytic activation of Vibrio cholera MARTX toxin (2009) (68)
- Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection Neuron Dendrite Targeting (2011) (68)
- “Velcro” Engineering of High Affinity CD47 Ectodomain as Signal Regulatory Protein α (SIRPα) Antagonists That Enhance Antibody-dependent Cellular Phagocytosis* (2015) (67)
- T-cell receptor structure and TCR complexes. (1997) (67)
- In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase (2017) (66)
- Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6. (2004) (66)
- Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins (2010) (66)
- Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c–I-Ek (2011) (63)
- Structural interplay between germline and adaptive recognition determines TCR-peptide-MHC cross-reactivity (2015) (63)
- Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation. (2001) (63)
- A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability (2018) (62)
- Topological control of cytokine receptor signaling induces differential effects in hematopoiesis (2019) (62)
- The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. (2002) (62)
- Structure of the IFNγ receptor complex guides design of biased agonists (2019) (61)
- New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation1 (2009) (61)
- Structural determinants of natriuretic peptide receptor specificity and degeneracy. (2006) (61)
- Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection (2010) (60)
- Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. (2010) (60)
- Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis (2014) (59)
- T cell receptor cross-reactivity expanded by dramatic peptide/MHC adaptability (2018) (58)
- Reconciling views on T cell receptor germline bias for MHC. (2012) (58)
- Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation1 (2008) (57)
- Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. (2020) (57)
- Recognition of angiotensin II: antibodies at different levels of an idiotypic network are superimposable. (1992) (55)
- TCR Scanning of Peptide/MHC through Complementary Matching of Receptor and Ligand Molecular Flexibility (2014) (55)
- Peptide register shifting within the MHC groove: theory becomes reality. (2004) (54)
- Emerging principles for T cell receptor recognition of antigen in cellular immunity. (1999) (53)
- Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling (2017) (53)
- Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism. (1994) (53)
- Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-β Signaling (2013) (52)
- Engineering and Characterization of a Stabilized α1/α2 Module of the Class I Major Histocompatibility Complex Product Ld* (2006) (51)
- Multifarious determinants of cytokine receptor signaling specificity. (2014) (51)
- An engineered IL-2 partial agonist promotes CD8+ T cell stemness (2020) (51)
- Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency (2015) (50)
- Structural architecture and functional evolution of Wnts. (2012) (49)
- Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo (2015) (48)
- Solution mapping of T cell receptor docking footprints on peptide-MHC (2007) (47)
- Not just any T cell receptor will do. (2003) (47)
- Accurate prediction of protein structures and interactions using a 3-track network (2021) (45)
- Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development (2017) (44)
- Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery (2021) (44)
- High-level bacterial secretion of single-chain αβ T-cell receptors (2005) (44)
- Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells (2021) (43)
- Diversity‐oriented approaches for interrogating T‐cell receptor repertoire, ligand recognition, and function (2012) (42)
- Design of a superior cytokine antagonist for topical ophthalmic use (2013) (41)
- Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers (2017) (40)
- Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10 (2021) (40)
- Inhibition of Delta-induced Notch signaling using fucose analogs (2017) (40)
- Wnt acylation and its functional implication in Wnt signalling regulation. (2015) (38)
- A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions (2020) (37)
- Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy (2018) (37)
- Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells (1998) (35)
- A structural template for gp130-cytokine signaling assemblies. (2002) (34)
- Stabilization of soluble, low-affinity HLA-DM/HLA-DR1 complexes by leucine zippers. (2002) (34)
- Immune receptor inhibition through enforced phosphatase recruitment (2020) (33)
- Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. (2008) (33)
- Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy (2018) (32)
- Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling (2020) (32)
- The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands (2017) (32)
- In vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130. (2001) (31)
- Receptor subtype discrimination using extensive shape complementary designed interfaces (2019) (30)
- Structure and selectivity engineering of the M1 muscarinic receptor toxin complex (2020) (29)
- Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures (2020) (29)
- Molecular interactions between extracellular components of the T‐cell receptor signaling complex (1999) (28)
- Different Strategies Adopted by Kb and Ld to Generate T Cell Specificity Directed against Their Respective Bound Peptides* (2009) (28)
- Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld. (2006) (26)
- Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation (2019) (26)
- The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. (2017) (26)
- Novel Factor V C2-Domain Mutation (R2074H) in Two Families with Factor V Deficiency and Bleeding (2002) (24)
- Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance. (2021) (24)
- Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling (2016) (24)
- Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro (2018) (23)
- Molecular architecture of the alpha beta T cell receptor-CD3 complex (2014) (23)
- A closer look at TCR germline recognition. (2012) (23)
- Although Divergent in Residues of the Peptide Binding Site, Conserved Chimpanzee Patr-AL and Polymorphic Human HLA-A*02 Have Overlapping Peptide-Binding Repertoires (2011) (23)
- Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments (2017) (22)
- T-cell receptor peptide-MHC interactions: biological lessons from structural studies. (1998) (20)
- Molecular model for DNA recognition by the family of basic-helix-loop-helix-zipper proteins. (1992) (20)
- A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C (2005) (19)
- Elucidation of the interleukin-15 binding site on its alpha receptor by NMR. (2007) (19)
- High-level bacterial secretion of single-chain alphabeta T-cell receptors. (2005) (17)
- The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. (2021) (17)
- Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants (2013) (16)
- Posttranslational Regulation of I-Ed by Affinity for CLIP1 (2007) (16)
- Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. (2021) (15)
- Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch (2019) (15)
- RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. (2019) (14)
- Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs1 (2001) (14)
- Distinct Structural Requirements for Interleukin-4 (IL-4) and IL-13 Binding to the Shared IL-13 Receptor Facilitate Cellular Tuning of Cytokine Responsiveness* (2009) (13)
- Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo (2020) (13)
- In vitro reconstitution and preparative purification of complexes between the chemokine receptor CXCR4 and its ligands SDF-1alpha, gp120-CD4 and AMD3100. (2006) (13)
- An autonomous CDR 3 d is sufficient for recognition of the nonclassical MHC class I molecules T 10 and T 22 by cd T cells (2008) (13)
- Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling (2020) (13)
- Processing and characterization of human proguanylin expressed in Escherichia coli. (1993) (12)
- Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors (2020) (12)
- Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens (2016) (11)
- Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies (2021) (11)
- A strategy for the selection of monovalent antibodies that span protein dimer interfaces (2019) (11)
- Dual Arms of Adaptive Immunity: Division of Labor and Collaboration between B and T Cells (2019) (11)
- Crystallization and preliminary X-ray diffraction data of an anti-angiotensin II Fab and of the peptide-Fab complex. (1989) (10)
- Synthetic cytokine circuits that drive T cell infiltration into immune-excluded tumors (2022) (10)
- Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma (2021) (9)
- Robust de novo design of protein binding proteins from target structural information alone (2021) (8)
- Membrane phosphoinositides stabilize GPCR-arrestin complexes and provide temporal control of complex assembly and dynamics (2021) (8)
- CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra low density cancer epitopes (2017) (8)
- An αß T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219. (2010) (7)
- Structure of the IL-27 quaternary receptor signaling complex (2022) (7)
- Posttranslational Regulation of I-E d by Affinity for CLIP 1 (2007) (7)
- Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist (2021) (7)
- Weiskopf Anticancer Antibodies Variants as Immunotherapeutic Adjuvants to α Engineered SIRP (2013) (7)
- T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes (2021) (6)
- CPDadh: A new peptidase family homologous to the cysteine protease domain in bacterial MARTX toxins (2009) (6)
- Facile method for screening clinical T cell receptors for off-target peptide-HLA reactivity (2018) (6)
- Do antiidiotypic antibodies mimic antigen? (1994) (6)
- Viral G Protein–Coupled Receptors Encoded by β- and γ-Herpesviruses (2022) (4)
- CD47-blocking therapies stimulate macrophage cytokine secretion and are effective in a model of peritoneal carcinomatosis (2015) (4)
- Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity (2020) (4)
- Crystal structure of the measles virus hemagglutinin (2007) (4)
- cytokine receptor complex (2005) (4)
- Structure of Interleukin-23 (2008) (3)
- In Vitro Reconstitution of T Cell Receptor–Mediated Segregation of the CD45 Phosphatase (2017) (3)
- Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform (2022) (3)
- Receptor subtype discrimination using extensive shape complementary designed interfaces (2019) (3)
- Tuning Cytokine Receptor Signaling by Reorienting Dimer Geometry with Surrogate Ligands Graphical (2015) (2)
- Structure of the extracellular segment of human TRKA in complex with nerve growth factor (2007) (2)
- Insights into immune structure, recognition, and signaling (2012) (2)
- The αβ T-cell receptor heterodimer: Crystal clear at last (1996) (2)
- 2064 (2017) (1)
- Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620 (2013) (1)
- Structure of a human A-type Potassium Channel Accelerating factor DPPX, a member of the dipeptidyl aminopeptidase family (2004) (1)
- Abstract B068: Structural basis for Notch1 engagement of Delta-like 4 and Jagged1 (2016) (1)
- Author response: Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo (2020) (1)
- CD47 Blockade Enhances Therapeutic Activity of TCR Mimic Antibodies to Ultra-Low Density Cancer Epitopes through Cytokine Feed Forward Mechanisms (2016) (1)
- Surrogate R-spondin agonists for tissue-specific potentiation of Wnt signaling (2018) (1)
- Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia (2020) (1)
- Combination therapy to enhance NK cell anti-tumor responses (2020) (1)
- Author response: Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development (2017) (1)
- Structure-activity mapping of the peptide- and force-dependent landscape of T-cell activation (2021) (1)
- Abstract 3629: Overcoming macrophage immunosuppression in small cell lung cancer with high-affinity SIRPa variants (2014) (1)
- Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8 (2012) (1)
- Powerful synergistic effects of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I+ tumors (2021) (1)
- Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex (2003) (1)
- Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineering (2021) (1)
- Interleukin 12 receptor subunit beta-1 (2021) (1)
- TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathways (2021) (1)
- Crystal Structure of SYG-2 D3-D4 (2014) (0)
- X-Ray Diffraction data from Fab bound to IL-4/IL-4Ra/gammaC complex, source of 6OEL structure (2019) (0)
- Crystal structure of leukemia inhibitory factor in complex with gp130 (2003) (0)
- X-Ray Diffraction data from Designed repeat protein specifically in complex with Fz7CRD, source of 6NE4 structure (2019) (0)
- Discovery of a novel shared tumor antigen in human lung cancer. (2020) (0)
- X-Ray Diffraction data from Fab bound to IL-4/IL-4Ra/gammaC complex, source of 6OEL structure (2019) (0)
- Interleukin-4 mutant RGA bound to cytokine receptor common gamma (2012) (0)
- Engineered Interleukin-13 bound to receptor (2015) (0)
- Structure of a viral GPCR bound to human chemokine CX3CL1 (2015) (0)
- Crystal Structure of Hormone/Receptor Complex (2001) (0)
- Conception à base structurale de mutants négatifs dominants d'il-17 (2012) (0)
- Structure of human Frizzled5 by fiducial-assisted cryo-EM (2020) (0)
- Crystal Structure of mouse Neph1 D1-D2 (2014) (0)
- IL-2 mutant D10 ternary complex (2012) (0)
- X-Ray Diffraction data from Designed repeat protein specifically in complex with Fz7CRD, source of 6NE4 structure (2019) (0)
- X-Ray Diffraction data from Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) , source of 4XLW structure (2015) (0)
- X-Ray Diffraction data from Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) , source of 4XLW structure (2015) (0)
- CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX (2001) (0)
- Engineered Fab bound to IL-4 receptor (2019) (0)
- Dimeric DARPin C_R3 complex with EpoR (2019) (0)
- 42F3 p5E8/H2-Ld complex (2011) (0)
- Il-13 superkine: immune cell targeting constructs and methods of use thereof (2017) (0)
- The structure of IL-13 in complex with IL-13Ralpha2 (2010) (0)
- Structure of the C. difficile TcdB cysteine protease domain (2011) (0)
- Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic (2019) (0)
- 2064: Deconstructing the peptide specificity of TCR recognition (2017) (0)
- CD47-diabody complex (2016) (0)
- Ligand-receptor structure (2010) (0)
- A Polymorphic Residue That Attenuates Interferon Lambda 4 Activity in Hominid Lineages (2018) (0)
- 42F3 TCR pCPB9/H-2Ld Complex (2015) (0)
- Crystal Structure of Hormone Receptor (2001) (0)
- Dimeric DARPin A_distance_R7 complex with EpoR (2019) (0)
- Structure of the Interleukin-15 quaternary complex (2012) (0)
- Science Signaling Podcast: 3 July 2012 (2012) (0)
- X-Ray Diffraction data from neoleukin-2/15, source of 6DG6 structure (2019) (0)
- Abstract A26: Towards the identification of novel tumor antigens in human lung cancer (2020) (0)
- Crystal Structure of H-2Kb bound to the dEV8 peptide (2002) (0)
- X-Ray Diffraction data from neoleukin-2/15, source of 6DG6 structure (2019) (0)
- Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) (2015) (0)
- Engineering cell-type selective immune responses using mechanism-based designer IL-4 cytokines. (57.8) (2011) (0)
- structure of interleukin-2 with its alpha receptor (2005) (0)
- Probing the Relationship between Extracellular Ligand Recognition and Cytokine Receptor Activation with Structural Biology and Protein Engineering (2013) (0)
- Structure of the Leukemia Inhibitory Factor Receptor (LIF-R) domains D1-D5 (2008) (0)
- X-Ray Diffraction data from Frizzled-8 complex with designed Wnt agonist, source of 5UN5 structure (2017) (0)
- The M33 TCR p3M33l/H-2 Ld Complex (2015) (0)
- Crystal structure of immune receptor complex (2007) (0)
- X-Ray Diffraction data from Frizzled-8 complex with designed Wnt agonist, source of 5UN5 structure (2017) (0)
- X-Ray Diffraction data from CD47 ectodomain with diabody 5F9, source of 5IWL structure (2016) (0)
- Crystal structure of mCardinal far-red fluorescent protein (2014) (0)
- D2 domain of human IFNAR2 (2011) (0)
- Crystal structure of the IL4-IL4R-Common Gamma ternary complex (2008) (0)
- Crystal Structure of Rst D1-D2 (2014) (0)
- crystal structure of a parasite protein (2002) (0)
- X-Ray Diffraction data from EpoR complex with dimeric DARPin ANR7, source of 6MOK structure (2019) (0)
- 2C/H-2Kbm3/dEV8 allogeneic complex (2002) (0)
- Protein-binding proteins designed from target structural information (2022) (0)
- Structure of the C. difficile TcdB cysteine protease domain in complex with a peptide inhibitor (2010) (0)
- Diabody 305 complex with EpoR (2015) (0)
- Rapid and accurate deorphanization of ligand-receptor pairs using AlphaFold (2023) (0)
- Structure of the Quaternary Complex of Interleukin-2 with Its [alpha], {szligbeta}, and [gamma][subscript c] Receptors (2005) (0)
- IL23/IL23R/IL12Rb1 signaling complex (2021) (0)
- structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide (2006) (0)
- Crystal structure of the IL13-IL4R-IL13Ra ternary complex (2008) (0)
- X-Ray Diffraction data from EpoR complex with dimeric DARPin ANR7, source of 6MOK structure (2019) (0)
- Structural basis for IL-12 and IL-23 shared receptor usage reveals a gateway for shaping actions on T versus NK cells (2021) (0)
- Structure of the 3alpham13 high-affinity mutant of the 2C TCR in complex with Ld/QL9 (2008) (0)
- 2B4 I-Ek TCR-MHC complex with affinity-enhancing Velcro peptide (2018) (0)
- Designed repeat protein in complex with Fz8 (2019) (0)
- Crystal structure of human artemin (2006) (0)
- Author response: Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling (2020) (0)
- Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism (2023) (0)
- Structural basis of TCR-pMHC recognition (1998) (0)
- TCR589 in complex with HIV(Pol448-456)/HLA-B35 (2018) (0)
- Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor (2009) (0)
- Author response: Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist (2021) (0)
- Interleukin-2 mutant D10 (2012) (0)
- Crystal structure of the 5cc7 TCR in complex with 5c1/I-Ek (2014) (0)
- X-Ray Diffraction data from nanobody-bound viral GPCR bound to human chemokine CX3CL1, source of 4XT1 structure (2016) (0)
- Designed repeat protein in complex with Fz4 (2019) (0)
- X-Ray Diffraction data from single chain complex of viral US28 with stabilizing nanobody nb7, source of 5WB1 structure (2018) (0)
- X-Ray Diffraction data from Engineered Interferon lambda in complex with IFN-lambdaR1 and IL10Rbeta, source of 5T5W structure (2017) (0)
- 1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination (2003) (0)
- Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1) (2015) (0)
- Crystal structure of the 2B4 TCR in complex with 2A/I-Ek (2014) (0)
- Designed repeat protein in complex with Fz7 (2019) (0)
- Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 (2013) (0)
- crystal structure of the non-classical MHC class Ib Qa-2 complexed with a self peptide (2001) (0)
- binary complex between IFNa2 and IFNAR2 (2011) (0)
- X-Ray Diffraction data from Drosophila Dpr6 D1 bound to DIPalpha D1+D2, source of 5EO9 structure (2016) (0)
- Microsoft Word-CD47Manuscript2.docx (2015) (0)
- Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75 (2004) (0)
- Structure of the IL-1b signaling complex (2012) (0)
- Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1 (2015) (0)
- Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer (2007) (0)
- Interleukin-10 signaling complex with IL-10RA and IL-10RB (2021) (0)
- Human IL-2/Fab complex (2018) (0)
- US28 bound to engineered chemokine CX3CL1.35 and nanobodies (2018) (0)
- X-Ray Diffraction data from neoleukin-2/15 complex with IL-2R beta and gamma receptors, source of 6DG5 structure (2019) (0)
- X-Ray Diffraction data from neoleukin-2/15 complex with IL-2R beta and gamma receptors, source of 6DG5 structure (2019) (0)
- Crystal Structure of SYG-1 D1, Crystal form 1 (2014) (0)
- Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody (2013) (0)
- Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody (2013) (0)
- Crystal Structure of Duf (Kirre) D1 (2014) (0)
- Monoextended DARPin M_R12 complex with EpoR (2019) (0)
- Frizzled-8 complex with designed surrogate Wnt agonist, A1 dataset (2017) (0)
- Structure of the V. cholerae RTX cysteine protease domain (2008) (0)
- Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A (2003) (0)
- Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A (2005) (0)
- Structure of the 2C/Ld/QL9 allogeneic complex (2007) (0)
- MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE (1997) (0)
- Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1 (2017) (0)
- Complex of high-affinity SIRP alpha variant FD6 with CD47 (2013) (0)
- Designed repeat protein specifically in complex with Fz7CRD (2019) (0)
- Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra (2013) (0)
- Role o f Chain Pairing for the Product ion o f Functional Soluble (2003) (0)
- Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody (2013) (0)
- Crystal Structure of SYG-1 D1-D2, refolded (2014) (0)
- Crystal Structure of H-2Kbm3 bound to dEV8 (2002) (0)
- New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2V617F Mutation (2019) (0)
- CHAPTER 45 – A New Paradigm of Cytokine Action Revealed by Viral IL-6 Complexed to gp130: Implications for GCSF Interaction with GCSFR (2003) (0)
- Crystal structure of m157 from mouse cytomegalovirus (2007) (0)
- X-Ray Diffraction data from complex of engineered human chemokine CX3CL1 with viral US28 and two nanobodies, source of 5WB2 structure (2018) (0)
- X-Ray Diffraction data from complex of engineered human chemokine CX3CL1 with viral US28 and two nanobodies, source of 5WB2 structure (2018) (0)
- Self-determination in the T cell repertoire. (2015) (0)
- STRUCTURE OF THE 2C/KB/DEV8 COMPLEX (1998) (0)
- Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo (2013) (0)
- X-Ray Diffraction data from 2B4-IEk TCR-MHC complex with affinity-enhancing Velcro peptide, source of 6BGA structure (2019) (0)
- This information is current as Ligand Molecular Flexibility Complementary Matching of Receptor and TCR Scanning of Peptide / MHC through (2014) (0)
- Author response: Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers (2017) (0)
- Mouse IL-2 Bound to S4B6 Fab Fragment (2015) (0)
- Dimeric DARPin C_angle_R5 complex with EpoR (2019) (0)
- human IFNa2-IFNAR ternary complex (2011) (0)
- X-Ray Diffraction data from 2B4-IEk TCR-MHC complex with affinity-enhancing Velcro peptide, source of 6BGA structure (2019) (0)
- Crystal Structure of SYG-1 D1, Crystal Form 2 (2014) (0)
- Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) (2017) (0)
- An Autonomous CDR 3 δ is Sufficient for γδ T Cell Recognition of the Nonclassical MHC-I T 10 / T 22 (2017) (0)
- Multiple thermodynamic mechanisms contribute to the binding of pepMHC ligands by wild type and high-affinity TCRs (93.16) (2007) (0)
- Fine-tuning of Epithelial EGFR signals Supports Coordinated Mammary Gland Development (2020) (0)
- TCR55 in complex with Pep20/HLA-B35 (2018) (0)
- A T cell receptor goes public. (2002) (0)
- Crystal Structure of the complex of Dpr6 Domain 1 bound to DIP-alpha Domain 1+2 (2016) (0)
- Peptides Based on MHC-TCR Binding Motifs OrderedAutoimmune Encephalomyelitis with Immunomodulation of Experimental (2001) (0)
- Ligand-free US28 with stabilizing intracellular nanobody (2018) (0)
- 42F3 TCR pCPA12/H-2Ld complex (2015) (0)
- Crystal Structure of the Complex of SYG-1 D1-D2 and SYG-2 D1-D4 (2014) (0)
- Crystal structure of the 5cc7 TCR in complex with 5c2/I-Ek (2014) (0)
- Crystal Structure of SYG-1 D1-D2, Glycosylated (2014) (0)
- Energetic Impact of Individual Peptide Residues on Binding by High-Affinity TCRs: Implications for Antigen Specificity (93.17) (2007) (0)
- The Diversity of Nuclear Magnetic Resonance Spectroscopy (2009) (0)
- Dimeric DARPin C_R3 (2019) (0)
- Mouse IL-2 Bound to JES6-1 scFv Fragment (2015) (0)
- CD47 Blockade Enhances Therapeutic Activity of TCR Mimic Antibodies to Ultra-Low Density Cancer Epitopes (2016) (0)
- Diabody 330 complex with EpoR (2015) (0)
- Antigen receptor signaling (WS-004) (2010) (0)
- Monomeric DARPin E2 complex with EpoR (2019) (0)
- X-Ray Diffraction data from Designed repeat protein in complex with Fz7, source of 6NE2 structure (2019) (0)
- X-Ray Diffraction data from IL-2 complex with Fab, source of 5UTZ structure (2018) (0)
- X-Ray Diffraction data from Designed repeat protein in complex with Fz7, source of 6NE2 structure (2019) (0)
- X-Ray Diffraction data from IL-2 complex with Fab, source of 5UTZ structure (2018) (0)
- Peptide-Binding Repertoires HLA-A*02 Have Overlapping Patr-AL and Polymorphic Human Chimpanzee Peptide Binding Site, Conserved Although Divergent in Residues of the (2011) (0)
- X-Ray Diffraction data from TCR589 in complex with HIV(Pol448-456)/HLA-B35, source of 6BJ2 structure (2019) (0)
- X-Ray Diffraction data from TCR589 in complex with HIV(Pol448-456)/HLA-B35, source of 6BJ2 structure (2019) (0)
- Crystal structure of immune receptor (2007) (0)
- Crystal structures of immune receptor complexes (2007) (0)
- X-Ray Diffraction data from Engineered IL-13 bound to receptor, source of 5E4E structure (2017) (0)
- De novo design of potent and selective mimics of IL-2 / IL-15 1 (2018) (0)
- X-Ray Diffraction data from Frizzled-8 complex with designed Wnt agonist, source of 5UN6 structure (2017) (0)
- Correction: CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes (1997) (0)
- X-Ray Diffraction data from Engineered IL-13 bound to receptor, source of 5E4E structure (2017) (0)
- X-Ray Diffraction data from TCR55 in complex with Pep20/HLA-B35, source of 6BJ8 structure (2019) (0)
- X-Ray Diffraction data from TCR55 in complex with Pep20/HLA-B35, source of 6BJ8 structure (2019) (0)
- X-Ray Diffraction data from Frizzled-8 complex with designed Wnt agonist, source of 5UN6 structure (2017) (0)
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What Schools Are Affiliated With Kenan Christopher Garcia?
Kenan Christopher Garcia is affiliated with the following schools:
