Karl L. Magleby
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Karl L. Maglebybiology Degrees
Biology
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#14204
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Physiology
#340
World Rank
#554
Historical Rank

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Biology
Karl L. Magleby's Degrees
- PhD Physiology University of Utah
- Bachelors Biology Brigham Young University
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Why Is Karl L. Magleby Influential?
(Suggest an Edit or Addition)Karl L. Magleby's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Properties of single calcium‐activated potassium channels in cultured rat muscle (1982) (753)
- A quantitative description of end‐plate currents (1972) (537)
- Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle (1986) (519)
- The effect of voltage on the time course of end‐plate currents (1972) (433)
- Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture (1981) (424)
- Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle (1984) (284)
- Calcium-activated potassium channels (1987) (263)
- Kinetic states and modes of single large‐conductance calcium‐activated potassium channels in cultured rat skeletal muscle. (1988) (242)
- Single voltage-dependent chloride-selective channels of large conductance in cultured rat muscle. (1983) (231)
- Calcium dependence of open and shut interval distributions from calcium‐activated potassium channels in cultured rat muscle. (1983) (230)
- Correcting single channel data for missed events. (1986) (215)
- Gating Mechanism of BK (Slo1) Channels (2003) (190)
- Quantitative description of three modes of activity of fast chloride channels from rat skeletal muscle. (1986) (189)
- Burst kinetics of single calcium‐activated potassium channels in cultured rat muscle. (1983) (180)
- A study of desensitization of acetylcholine receptors using nerve‐released transmitter in the frog (1981) (167)
- Voltage and Ca2+ Activation of Single Large-Conductance Ca2+-Activated K+ Channels Described by a Two-Tiered Allosteric Gating Mechanism (2000) (162)
- Augmentation: A process that acts to increase transmitter release at the frog neuromuscular junction. (1976) (162)
- The β Subunit Increases the Ca2+ Sensitivity of Large Conductance Ca2+-activated Potassium Channels by Retaining the Gating in the Bursting States (1999) (149)
- The effect of repetitive stimulation on facilitation of transmitter release at the frog neuromuscular junction (1973) (144)
- A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification (2003) (142)
- Gating Kinetics of Single Large-Conductance Ca2+-Activated K+ Channels in High Ca2+ Suggest a Two-Tiered Allosteric Gating Mechanism✪ (1999) (138)
- Linker-Gating Ring Complex as Passive Spring and Ca2+-Dependent Machine for a Voltage- and Ca2+-Activated Potassium Channel (2004) (138)
- Factors affecting the time course of decay of end‐plate currents: a possible cooperative action of acetylcholine on receptors at the frog neuromuscular junction. (1975) (137)
- Single chloride-selective channels active at resting membrane potentials in cultured rat skeletal muscle. (1985) (121)
- Linker-Gating Ring Complex as Passive Spring and Ca2+-Dependent Machine for a Voltage- and Ca2+-Activated Potassium Channel (2005) (118)
- A quantitative description of stimulation-induced changes in transmitter release at the frog neuromuscular junction (1982) (116)
- A quantitative description of tetanic and post‐tetanic potentiation of transmitter release at the frog neuromuscular junction. (1975) (107)
- Sampling, log binning, fitting, and plotting durations of open and shut intervals from single channels and the effects of noise (1987) (105)
- The effect of (+)‐tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog. (1981) (104)
- Changes in miniature endplate potential frequency during repetitive nerve stimulation in the presence of Ca2+, Ba2+, and Sr2+ at the frog neuromuscular junction (1981) (101)
- A dual effect of repetitive stimulation on post‐tetanic potentiation of transmitter release at the frog neuromuscular junction. (1975) (95)
- Facilitation, augmentation, and potentiation of synaptic transmission at the superior cervical ganglion of the rabbit (1980) (95)
- Augmentation and facilitation of transmitter release. A quantitative description at the frog neuromuscular junction (1982) (94)
- Inverse relationship of the durations of adjacent open and shut intervals for Cl and K channels (1985) (93)
- Fractal models are inadequate for the kinetics of four different ion channels. (1988) (92)
- The effect of tetanic and post‐tetanic potentiation on facilitation of transmitter release at the frog neuromuscular junction (1973) (85)
- Functional Coupling of the β1 Subunit to the Large Conductance Ca2+-Activated K+ Channel in the Absence of Ca2+ (2000) (80)
- Kinetic time constants independent of previous single-channel activity suggest Markov gating for a large conductance Ca-activated K channel (1989) (80)
- Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism. (2000) (79)
- Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+ (2002) (77)
- Estimating kinetic parameters for single channels with simulation. A general method that resolves the missed event problem and accounts for noise. (1990) (76)
- Intra- and Intersubunit Cooperativity in Activation of BK Channels by Ca2+ (2006) (67)
- Differential effects of Ba2+, Sr2+, and Ca2+ on stimulation-induced changes in transmitter release at the frog neuromuscular junction (1980) (65)
- Voltage‐induced slow activation and deactivation of mechanosensitive channels in Xenopus oocytes (1997) (63)
- Wanderlust kinetics and variable Ca(2+)-sensitivity of Drosophila, a large conductance Ca(2+)-activated K+ channel, expressed in oocytes. (1996) (62)
- Long term changes in augmentation, potentiation, and depression of transmitter release as a function of repeated synaptic activity at the frog neuromuscular junction. (1976) (62)
- Voltage- and cold-dependent gating of single TRPM8 ion channels (2011) (59)
- Identifying kinetic gating mechanisms for ion channels by using two-dimensional distributions of simulated dwell times (1990) (57)
- Is the quantum of transmitter release composed of subunits? A critical analysis in the mouse and frog (1981) (56)
- Nickel and calcium ions modify the characteristics of the acetylcholine receptor‐channel complex at the frog neuromuscular junction. (1980) (55)
- Kinetic Structure of Large-Conductance Ca2+-activated K+ Channels Suggests that the Gating Includes Transitions through Intermediate or Secondary States (1998) (54)
- Preventing errors when estimating single channel properties from the analysis of current fluctuations. (1993) (52)
- Probing the Geometry of the Inner Vestibule of BK Channels with Sugars (2005) (50)
- Slo1 Tail Domains, but Not the Ca2+ Bowl, Are Required for the β1 Subunit to Increase the Apparent Ca2+ Sensitivity of BK Channels (2002) (48)
- Facilitation, augmentation, and potentiation of transmitter release. (1979) (47)
- Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg2+ and Polyamines through Electrostatics (2006) (46)
- High Ca2+ concentrations induce a low activity mode and reveal Ca2(+)‐independent long shut intervals in BK channels from rat muscle. (1996) (46)
- Dependency plots suggest the kinetic structure of ion channels (1992) (46)
- Testing for microscopic reversibility in the gating of maxi K+ channels using two-dimensional dwell-time distributions. (1994) (45)
- Opening and closing transitions for BK channels often occur in two steps via sojourns through a brief lifetime subconductance state. (1993) (43)
- Properties of Slo1 K+ channels with and without the gating ring (2013) (42)
- Ionic requirements for membrane-glass adhesion and giga seal formation in patch-clamp recording. (2007) (41)
- β1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms (2003) (38)
- Protons Block BK Channels by Competitive Inhibition with K+ and Contribute to the Limits of Unitary Currents at High Voltages (2004) (38)
- Augmentation Increases Vesicular Release Probability in the Presence of Masking Depression at the Frog Neuromuscular Junction (2004) (37)
- Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2+. (1977) (36)
- Gating and Conductance Properties of Bk Channels Are Modulated by the S9–S10 Tail Domain of the α Subunit (2001) (33)
- Fractal models, Markov models, and channel kinetics. (1989) (33)
- Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume (2011) (32)
- Modal gating of NMDA receptors (2004) (30)
- Testing for detailed balance (microscopic reversibility in ion channel gating. (2001) (29)
- Zinc potentiates neuronal nicotinic receptors by increasing burst duration. (2008) (28)
- Single-channel kinetics of BK (Slo1) channels (2014) (28)
- Voltage-induced membrane displacement in patch pipettes activates mechanosensitive channels. (1999) (28)
- Linking Exponential Components to Kinetic States in Markov Models for Single-Channel Gating (2008) (27)
- Two-dimensional components and hidden dependencies provide insight into ion channel gating mechanisms. (1997) (26)
- Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+ (2010) (26)
- A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities (2017) (25)
- Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels. (2001) (23)
- Membrane-pipette interactions underlie delayed voltage activation of mechanosensitive channels in Xenopus oocytes. (1999) (22)
- Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels (2017) (20)
- Mg2+ binding to open and closed states can activate BK channels provided that the voltage sensors are elevated (2011) (19)
- Short Isoforms of the Cold Receptor TRPM8 Inhibit Channel Gating by Mimicking Heat Action Rather than Chemical Inhibitors* (2011) (16)
- Two-dimensional kinetic analysis suggests nonsequential gating of mechanosensitive channels in Xenopus oocytes. (2001) (15)
- Time-irreversible Subconductance Gating Associated with Ba2+ Block of Large Conductance Ca2+-activated K+ Channels (1998) (15)
- Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel. (1999) (14)
- Differential Effects of Ba 2 + , Sr 2 + , and Ca 2 + on Stimulation-induced Changes in Transmitter Release at the Frog Neuromuscular Junction (2003) (14)
- Erratum: Wanderlust kinetics and variable Ca2+-sensitivity of dSlo, a large conductance Ca2+-activated K+ channel, expressed in oocytes (Biophysical Journal (1996) 70 (2640-2651)) (1996) (12)
- Exponential sum-fitting of dwell-time distributions without specifying starting parameters. (2013) (11)
- Recording from calcium-activated potassium channels. (1992) (11)
- Kinetic Gating Mechanisms for Bk Channels (2001) (11)
- Coupling of Ca2+ and voltage activation in BK channels through the αB helix/voltage sensor interface (2020) (10)
- The Number of Components of Enhancement Contributing to Short-Term Synaptic Plasticity at the Neuromuscular Synapse during Patterned Nerve Stimulation Progressively Decreases As Basal Release Probability Is Increased from Low to Normal Levels by Changing Extracellular Ca2+ (2011) (9)
- Structural biology: Ion-channel mechanisms revealed (2016) (9)
- Investigating single-channel gating mechanisms through analysis of two-dimensional dwell-time distributions. (1998) (7)
- Beating the Odds with Big K (1999) (7)
- Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers (2013) (6)
- Kinetic Gating Mechanisms for BK Channels: When Complexity Leads to Simplicity (2001) (6)
- Wanderlust kinetics and variable Ca(2+)-sensitivity of dSlo [correction of Drosophila], a large conductance CA(2+)-activated K+ channel, expressed in oocytes. (1996) (5)
- Ca 2 1 -Dependent Gating Mechanisms for dSlo, a Large-Conductance Ca 2 1 -Activated K 1 (BK) Channel (1999) (5)
- Functional Coupling of the b 1 Subunit to the Large Conductance Ca 2 1-activated K 1 Channel in the Absence of Ca 2 1 Increased Ca 2 1 Sensitivity from a Ca 2 1-independent Mechanism (2000) (4)
- Post tetanic potentiation at the neuro muscular junction can be described assuming a linear relationship to a substance which accumulates in the pre synaptic nerve terminal (1974) (3)
- Modal gating of endplate acetylcholine receptors: A proposed mechanism (2015) (3)
- Effect of repetitive stimulation on augmentation of transmitted release at the frog neuromuscular junction (1977) (3)
- Erratum: Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+ (Proceedings of the National Academy of Sciences of the United States (August 20, 2002) 99:17 (11441-11446)) (2003) (2)
- Neuromuscular Junction (NMJ): Presynaptic Short-Term Plasticity of Neuromuscular Transmission (2009) (2)
- Voltage- and Ca2+-Activation of BK Channels Studied with Highly Constrained Allosteric Gating Mechanisms (2012) (1)
- Deletion of Cytoplasmic Gating Ring Alters Voltage Dependent Activation of BK Channels (2016) (1)
- An ensemble of toxic channel types underlies the severity of the de novo variant G375R of the human BK channel (2021) (1)
- Voltage Sensor Activation Facilitates Magnesium-Gated Channel Opening in BK Channels (2010) (1)
- An allosteric modulator activates BK channels by perturbing coupling between Ca2+ binding and pore opening (2022) (1)
- Repeated binding of acetylcholine to receptors can prolong end plate currents in the presence of prostigmin (1974) (1)
- BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy (2022) (1)
- The (cid:98) Subunit Increases the Ca 2 (cid:49) Sensitivity of Large Conductance Ca 2 (cid:49) -activated Potassium Channels by Retaining the Gating in the Bursting States (1999) (0)
- A genetic variant of the sperm-specific SLO3 K (cid:2) channel has altered pH and Ca 2 (cid:2) sensitivities (2017) (0)
- Time-irreversible Subconductance Gating Associated with Ba 2 1 Block of Large Conductance Ca 2 1-activated K 1 Channels (1998) (0)
- Coupling between Ca2+ binding and the activation gate opening in BK channels probed by an allosteric activator (2022) (0)
- An allosteric agonist activates BK channels by perturbing coupling between Ca2+ binding and pore opening (2022) (0)
- Contributions of the Inner Cavity to the Resistance of High Conductance K+ Channels Determined with a Two-Resistor Model (2012) (0)
- Baseline Properties of Slo1 K+ (BK) Channels Without the Gating Ring (2014) (0)
- Single chloride channels in skeletal muscle (1989) (0)
- Gating Kinetics of Single Large-Conductance Ca 2 (cid:49) -activated K (cid:49) Channels in High Ca 2 (cid:49) Suggest a Two-Tiered Allosteric Gating Mechanism J (1999) (0)
- Erratum: (Journal of General Physiology (February 2003) 121, 2 (81-96)) (2004) (0)
- Erratum: (Biophysical Journal (1994) 67 (91-104)) (1994) (0)
- Calculating Conductance and Size of the Entrance to the Inner Cavity of BK Channels with Side-Chain Replacement and a Two-Resistor Model (2011) (0)
- Correction (2004) (0)
- Alpha-B Helix of RCK1 is a Major Transduction Pathway for Ca2+ Activation of BK Channels (2017) (0)
- Alpha-B Helix of the RCK1 Domain is a Shared Structural Element for Both Voltage and Calcium Activation of BK Channels (2018) (0)
- Erratum: (Journal of General Physiology (July 1999) 114:1 (93-124)) (1999) (0)
- Corrections (1988) (0)
- Contents page + Editorial Board (2004) (0)
- Voltage Sensor Deactivation Inhibits BK Channel Opening by Mg2 (2011) (0)
- Voltage Dependent Gating of BK Channels - Where is the Spring? (2019) (0)
- Erratum: (The Journal of General Physiology (October 2, 2006) 128, 4, (389-404)) (2006) (0)
- Exploring Whether a Large Entrance To The Inner Vestibule Of BK Channels Is Required For Their Large Conductance (2009) (0)
- Correction: The journal of general physiology (2006) (0)
- Slo1 Tail Domains, but Not the Ca 2 (cid:2) Bowl, Are Required for the (cid:3) 1 Subunit to Increase the Apparent Ca 2 (cid:2) Sensitivity of BK Channels (2002) (0)
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