Kazuyuki Morihara
#158,156
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Kazuyuki Moriharachemistry Degrees
Chemistry
#4499
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#5582
Historical Rank
Organic Chemistry
#746
World Rank
#843
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Chemistry
Kazuyuki Morihara's Degrees
- PhD Chemistry University of Tokyo
Why Is Kazuyuki Morihara Influential?
(Suggest an Edit or Addition)Kazuyuki Morihara's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- PSEUDOMONAS AERUGINOSA ELASTASE. ISOLATION, CRYSTALLIZATION, AND PRELIMINARY CHARACTERIZATION. (1965) (244)
- PRODUCTION OF ELASTASE AND PROTEINASE BY PSEUDOMONAS AERUGINOSA (1964) (226)
- Comparative specificity of microbial proteinases. (1974) (185)
- Protease and elastase of Pseudomonas aeruginosa: inactivation of human plasma alpha 1-proteinase inhibitor (1979) (174)
- Thermolysin: kinetic study with oligopeptides. (1970) (161)
- Comparison of the specificities of various neutral proteinases from microorganisms. (1968) (153)
- Pseudomonas aeruginosa proteinase: I. Purification and general properties (1963) (143)
- Specific cleavage of human type III and IV collagens by Pseudomonas aeruginosa elastase (1986) (140)
- Using proteases in peptide synthesis (1987) (130)
- alpha-Chymotrypsin as the catalyst for peptide synthesis. (1977) (121)
- Degradation of IgA proteins by Pseudomonas aeruginosa elastase. (1990) (120)
- Enzyme-assisted semisynthesis of human insulin (1979) (115)
- Semi-synthesis of human insulin by trypsin-catalysed replacement of Ala-B30 by Thr in porcine insulin (1979) (114)
- Degradation of soluble laminin and depletion of tissue-associated basement membrane laminin by Pseudomonas aeruginosa elastase and alkaline protease (1986) (95)
- Production of protease and elastase by Pseudomonas aeruginosa strains isolated from patients (1977) (91)
- Serralysin and related bacterial proteinases. (1995) (83)
- Structural gene and complete amino acid sequence of Pseudomonas aeruginosa IFO 3455 elastase (1989) (83)
- Purification of human plasma alpha 1-proteinase inhibitor and its inactivation by Pseudomonas aeruginosa elastase. (1984) (78)
- Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin. (1986) (78)
- Substrate specificity of elastolytic and nonelastolytic proteinases from Pseudomonas aeruginosa. (1966) (75)
- Structural gene and complete amino acid sequence of Vibrio alginolyticus collagenase. (1992) (75)
- Multiple proteolytic enzymes of Streptomyces fradiae. Production, isolation, and preliminary characterization. (1967) (69)
- Effectiveness of immunization with single and multi-component vaccines prepared from a common antigen (OEP), protease and elastase toxoids of Pseudomonas aeruginosa on protection against hemorrhagic pneumonia in mink due to P. aeruginosa. (1978) (61)
- Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455 (1990) (58)
- Trypsin as a catalyst for peptide synthesis. (1977) (56)
- Peptide bond synthesis catalyzed by thermolysin. (1980) (55)
- The specificities of various neutral and alkaline proteinases from microorganisms. (1967) (50)
- Subtilisin BPN': kinetic study with oligopeptides. (1970) (50)
- Achromobacter protease I-catalyzed conversion of porcine insulin into human insulin. (1980) (49)
- Pseudomonas aeruginosa Elastase: Affinity Chromatography and Some Properties as a Metallo-neutral Proteinase (1975) (49)
- Is the site of action of grayanotoxin the sodium channel gating of squid axon? (1985) (48)
- Effects of protease and elastase from Pseudomonas aeruginosa on skin. (1975) (47)
- Peptide Bond Synthesis Catalyzed by α-Chymotrypsin (1978) (47)
- Elastolytic properties of various proteinases from microbial origin. (1967) (47)
- The complex active sites of bacterial neutral proteases in relation to their specificities. (1968) (46)
- Comparison of α-chymotrypsin and subtilisin BPN1: Size and specificity of the active site (1969) (45)
- In vivo studies on protease and elastase from Pseudomonas aeruginosa. (1975) (45)
- Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection (1993) (44)
- Crystal structure of the unliganded alkaline protease from Pseudomonas aeruginosa IFO3080 and its conformational changes on ligand binding. (1995) (44)
- Pseudolysin and other pathogen endopeptidases of thermolysin family. (1995) (43)
- Proteolytic substrate specificity and some elastolytic properties of a thermostable bacterial proteinase. (1966) (42)
- Comparison of the specificities of various serine proteinases from microorganisms. (1969) (41)
- Peptide bond synthesis catalyzed by subtilisin, papain, and pepsin. (1981) (38)
- Subtilisin BPN': inactivation by chloromethyl ketone derivates of peptide substrates. (1970) (36)
- Coupling between Cbz-Arg-OH and Leu-X catalyzed by trypsin and papain. (1980) (36)
- Specificity of Proteinase K from Tritirachium album Limber for Synthetic Peptides (1975) (33)
- A kinetic investigation of subsites S1′ and S2′ in α-chymotrypsin and subtilisin BPN′ (1977) (32)
- Comparison of various types of subtilisins: size and properties of the active site. (1971) (32)
- Comparative specificity of microbial acid proteinases for synthetic peptides. 3. Relationship with their trypsinogen activating ability. (1973) (29)
- On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides. (1973) (29)
- The compound active site of Bacillus subtilis neutral protease: some properties of six subsites. (1969) (27)
- A trypsin-like protease from Streptomyces fradiae. (1968) (27)
- Influence of temperature on the enzymic semisynthesis of human insulin by coupling and transpeptidation methods. (1986) (27)
- Pseudomonas aeruginosa proteinase. II. Molecular weight and molecular dimension. (1963) (26)
- Phosphoramidon as an inhibitor of elastase from Pseudomonas aeruginosa. (1978) (26)
- Effect of secondary interaction on the enzymatic activity of subtilisin BPN′: Comparison with α‐chymotrypsin, trypsin, and elastase (1973) (25)
- On the Specificity of a Rennin-like Enzyme from Mucor pusillus (1973) (25)
- PSEUDOMONAS AERUGINOSA PEPTIDE PEPTIDOHYDROLASE. 3. SOME CHARACTERS AS A CA2+-METALLOENZYME. (1964) (24)
- Comparative study of various serine proteinases from microorganisms: specificity with oligopeptides. (1971) (23)
- On the specificity of Bacillus subtilis neutral protease in relation to the compound active site. (1969) (22)
- Comparative specificity of microbial acid proteinases for synthetic peptides. I. Primary specificity. (1973) (20)
- Cloning and characterization of elastase structural gene from Pseudomonas aeruginosa IFO 3455. (1988) (19)
- Comparative specificity of microbial acid proteinases for synthetic peptides. Primary specificity with Z-tetrapeptides. (1974) (19)
- Detection of elastase production in Escherichia coli with the elastase structural gene from several non-elastase-producing strains of Pseudomonas aeruginosa (1991) (18)
- Microbial degradation of proteins. (1992) (18)
- Cloning and expression of the alkaline proteinase gene from Pseudomonas aeruginosa IFO 3455 (1989) (18)
- Some physicochemical properties and substrate specificity of acid protease b of scytalidium lignicolum atcc 24568 (1975) (17)
- Studies on the Protease of Pseudomonas (1957) (17)
- Specificity of pepsin: Size and property of the active site (1970) (17)
- Enzymatic synthesis of delta sleep-inducing peptide. (2009) (16)
- Effect of secondary interaction on the enzymatic activity of trypsin-like enzymes from Streptomyces. (1973) (16)
- Comparative specificity of microbial acid proteinases for synthetic peptides. II. Effect of secondary interaction. (1973) (16)
- Some Physicochemical Properties and Substrate Specificities of Acid Proteases A-1 and A-2 of Scytalidium lignicolumn ATCC 24568 (1976) (15)
- Comparative study of various neutral proteinases from microorganisms: specificity with oligopeptides. (1971) (15)
- Pepstatin-insenstive acid proteases from Scytalidium lignicolum. Kinetic study with synthetic peptides. (1979) (15)
- Distribution of Sarcophytol A in Soft Coral of the Sarcophyton Genus (2000) (15)
- Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates. (1974) (15)
- Enzymatic synthesis of cholecystokinin-octapeptide. (1988) (15)
- Use of immobilized trypsin for semisynthesis of human insulin. (1989) (13)
- Production of proteinase on noncarbohydrate carbon sources by Pseudomonas aeruginosa. (1965) (12)
- Comparison of substrate specificities of a thermostable bacterial proteinase and a bacterial elastase. (1967) (12)
- Kinetics of aspartame precursor synthesis catalysed by Pseudomonas aeruginosa elastase (2007) (12)
- Proteolytic cleavage of exotoxin a form Pseudomonas aeruginosa (1980) (11)
- Enzymatic semisynthesis of human insulin: An update (1990) (11)
- PSEUDOMONAS AERUGINOSA PEPTIDE PEPTIDOHYDROLASE. IV. OPTICAL ROTATORY DISPERSION AND AMINO ACID COMPOSITION. (1964) (11)
- Molecular Cloning and Partial DNA Sequencing of the Collagenase Gene of Vibrio alginolyticus (1990) (11)
- Effect of Cobalt Ion on the Enzymatic Activity of Pseudomonas aeruginosa Alkaline Proteinase (1974) (11)
- Immunoreactivity and Biologic Activity of Semisynthetic [LeuB30]-Insulin: Potential Value in the Treatment of Insulin Antibody-Mediated Insulin Resistance (1981) (10)
- Dissection of the promoter/operator region and evaluation of N-acylhomoserine lactone mediated transcriptional regulation of elastase expression in Pseudomonas aeruginosa. (1997) (10)
- Long-Range Effect of Mutation of Calcium Binding Asparates on the Catalytic Activity of Alkaline Protease from Pseudomonas aeruginosa (1998) (10)
- Structural studies on anti-inflammatory polysaccharides from Streptomyces fradiae. (1974) (9)
- Acyl and amino intermediates in reactions catalyzed by thermolysin. (1978) (9)
- Thermolysin-catalyzed synthesis of peptide amides. (1988) (9)
- Affinity purification of kallikrein and elastase from hog pancrease powder. (1986) (8)
- New method of preparing elastase toxoid from Pseudomonas aeruginosa (1986) (7)
- Proteolytic cleavage of exotoxin A from Pseudomonas aeruginosa: formation of an ADP-ribosyltransferase active fragment by the action of Pseudomonas elastase. (1980) (7)
- Studies on the Protease of Pseudomonas :Part II. Crystallization of the Protease and its Physico-chemical and General Properties (1957) (7)
- Substrate Specificities of the Proteases from a Marine-psychrophilic Bacterium, Pseudomonas sp. No. 548 (1974) (7)
- Papain-catalyzed synthesis of aspartame precursor: A comparison with thermolysin (1998) (7)
- Specificity of Proteinase K fromTritirachium albumLimber for Synthetic Peptides (1975) (6)
- Alternative synthesis of the carboxyl terminal tetrapeptide amide of cholecystokinin by means of proteases (1987) (6)
- Studies on the Protease of Pseudomonas :Part VIII. Proteinase Productions of Various Pseudomonas Species, Especially Ps. aeruginosa (1962) (6)
- Long-range effect of mutation of calcium binding aspartates [correction of asparates] on the catalytic activity of alkaline protease from Pseudomonas aeruginosa. (1998) (6)
- Comparison of the effects of a multi-component vaccine and a formalin-killed cell vaccine on protection against enzootic of hemorrhagic pneumonia due to Pseudomonas aeruginosa in mink. (1981) (6)
- A new procedure for enzymatic semisynthesis of human insulin by hydrolysis of single-chain des-(b-30)-lnsulin precursor with lysyl endopeptidase. (1991) (5)
- Use of Bacillus brevis for Synthesis and Secretion of Des-B30 Single-Chain Human Insulin Precursor (2000) (5)
- Use of immobilized Achromobacter protease I for semisynthesis of human insulin. (1987) (5)
- Elastase gene expression in non-elastase-producing Pseudomonas aeruginosa strains using novel shuttle vector systems. (1994) (4)
- [Two metalloproteinases produced from Pseudomonas aeruginosa, especially on the structure of active site and substrate specificity]. (1992) (4)
- Studies on the Protease of Pseudomonas: Part IV. Factors Affecting the Enzyme Production, Especially on the Effect of CalciumPart V. On the Role of Calcium in the Enzyme Production (1959) (4)
- Protection against hemorrhagic pneumonia of mink by Pseudomonas aeruginosa multicomponent vaccine. (1979) (4)
- Effects of proteases on the structure and activity of Pseudomonas aeruginosa exotoxin A (1981) (4)
- Primary structure of Pseudomonas aeruginosa elastase. A comparison with thermolysin. (1989) (4)
- Site-Directed Mutagenesis of His-176 and Glu-177 in Pseudomonas aeruginosa Alkaline Protease : Effect on Catalytic Activity (1997) (4)
- Studies on the Protease of Pseudomonas :Part V. On the Role of Calcium in the Enzyme Production (1959) (3)
- [Peptide bond synthesis catalyzed by various proteases (author's transl)]. (1981) (3)
- Thermolysin catalyzed semisynthesis of peptide hormones by introduction of Phe-NH2 or Tyr-NH2 at the carboxyl termini. (1991) (3)
- Comparison of alpha-chymotrypsin and subtilisin BPN': size and specificity of the active site. (1969) (2)
- [Serralysin Zn-metalloproteinases--structure, function, secretion pathway, and pathogenicity]. (2000) (2)
- [Enzymatic synthesis of peptides]. (1984) (2)
- Peptide bond synthesis catalyzed by alpha-chymotrypsin. (1978) (2)
- Elastase Activity of some Purified Proteinase Preparations as Related to their Depilatory Action (1965) (2)
- Aspartame precursor synthesis in water miscible cosolvent catalysed by thermolysin (1992) (2)
- Studies on the Protease of Pseudomonas :Part I. The Production of the Enzyme under Various Cultural Conditions (1956) (1)
- Studies on the Protease of Pseudomonas :Part VII. An Immunological Study of the Crystalline Proteinase (1960) (1)
- A chloroacetyl peptide derivative as an inhibitor of thiol proteinases. (1985) (1)
- Studies on the Protease of Pseudomonas: Part III. Specific Action of the Protease (1957) (1)
- Signal peptidase cleavage site in the processing of Pseudomonas aeruginosa preproelastase (1994) (1)
- Process for the preparation of human insulin (1980) (1)
- A kinetic investigation of subsites S1' and S2' in alpha-chymotrypsin and subtilisin BPN'. (1977) (1)
- Inactivation of papain with chloroacetyl amino acid derivatives. (1986) (1)
- PRODUCTIONOF ELASTASEAND PROTEINASEBY PSEUDOMONAS AERUGINOSA (1964) (0)
- PEPTIDE SYNTHESIS USING ENZYME AS SYNTHETIC CATALYST. SYNTHESIS OF NEW WATER-SOLUBLE ESTER SUBSTRATES AND ENZYME IMMOBILIZATION (1984) (0)
- Acid Carboxypeptidase-like Activity Contaminating Proctase B (1973) (0)
- [Acid proteases (author's transl)]. (1977) (0)
- [Bacterial intercellular communication and environmental adaptation]. (2000) (0)
- Crystal Structure of Alkaline Protease from Pseudomonas Aeruginosa IFO3455 (1994) (0)
- Milk-clotting or Blood-coagulating Activities of Some Proteinases and their Substrate Specificities (1965) (0)
- Elastolytic Activities of Various Microbial Proteinases and their Proteolytic Substrate Specificities (1967) (0)
- ALKALINE PROTEASE FROM PSEUDOMONAS AERUGINOSA IFO3080 (1996) (0)
- Studies on the Protease of Pseudomonas :Part VI. On the Role of Ca in the Enzyme Production (supplemented) (1960) (0)
- United States Patent ( 19 Morihara et al . 54 SEMI-SYNTHESIS OF HUMAN INSULIN (2017) (0)
- Enzymatic semisynthesis of human insulin. (1986) (0)
- Use of Bacntus brevts for Synthesis Human Insulin Precursor andSecretion of Des-B 30 Single-Chain (2017) (0)
- Enzymatic semisynthesis of [Leu B30] insulin (2009) (0)
- Enzymatic semisynthesis of [LeuB30] insulin. (1986) (0)
- A process for preparing oeb30-Thr (R 1) (R 2) aa - insulin (1981) (0)
- Studies on the protease of Pseudomonas,pt.6,7. (1960) (0)
- Production ofProteinase on Noncarbohydrate Carbon Sources byPseudomonas aeruginosa (1965) (0)
- Effects of methanol on the synthesis of aspartame precursor catalysed byPseudomonas aeruginosa elastase (1992) (0)
- [Binding sites of subtilisin]. (1972) (0)
- Purification of Aspergillus oryzae Acid Proteinase: Contamination with Acid Carboxypeptidase-like Activity (1973) (0)
- Enzymatic Synthesis of Cholecystokinin-octapeptide1) (2010) (0)
- Y Pseudomonas aeruginosa . several non-elastase-producing strains of coli with the elastase structural gene from Detection of elastase production in Escherichia (0)
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