Kazuyuki Morihara

Kazuyuki Morihara's AcademicInfluence.com Rankings

Kazuyuki Morihara

Chemistry

#4499

World Rank

#5582

Historical Rank

Organic Chemistry

#746

World Rank

#843

Historical Rank

chemistry Degrees

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Chemistry

Kazuyuki Morihara's Degrees

PhD Chemistry University of Tokyo

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Kazuyuki Morihara's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

PSEUDOMONAS AERUGINOSA ELASTASE. ISOLATION, CRYSTALLIZATION, AND PRELIMINARY CHARACTERIZATION. (1965) (244)
PRODUCTION OF ELASTASE AND PROTEINASE BY PSEUDOMONAS AERUGINOSA (1964) (226)
Comparative specificity of microbial proteinases. (1974) (185)
Protease and elastase of Pseudomonas aeruginosa: inactivation of human plasma alpha 1-proteinase inhibitor (1979) (174)
Thermolysin: kinetic study with oligopeptides. (1970) (161)
Comparison of the specificities of various neutral proteinases from microorganisms. (1968) (153)
Pseudomonas aeruginosa proteinase: I. Purification and general properties (1963) (143)
Specific cleavage of human type III and IV collagens by Pseudomonas aeruginosa elastase (1986) (140)
Using proteases in peptide synthesis (1987) (130)
alpha-Chymotrypsin as the catalyst for peptide synthesis. (1977) (121)
Degradation of IgA proteins by Pseudomonas aeruginosa elastase. (1990) (120)
Enzyme-assisted semisynthesis of human insulin (1979) (115)
Semi-synthesis of human insulin by trypsin-catalysed replacement of Ala-B30 by Thr in porcine insulin (1979) (114)
Degradation of soluble laminin and depletion of tissue-associated basement membrane laminin by Pseudomonas aeruginosa elastase and alkaline protease (1986) (95)
Production of protease and elastase by Pseudomonas aeruginosa strains isolated from patients (1977) (91)
Serralysin and related bacterial proteinases. (1995) (83)
Structural gene and complete amino acid sequence of Pseudomonas aeruginosa IFO 3455 elastase (1989) (83)
Purification of human plasma alpha 1-proteinase inhibitor and its inactivation by Pseudomonas aeruginosa elastase. (1984) (78)
Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin. (1986) (78)
Substrate specificity of elastolytic and nonelastolytic proteinases from Pseudomonas aeruginosa. (1966) (75)
Structural gene and complete amino acid sequence of Vibrio alginolyticus collagenase. (1992) (75)
Multiple proteolytic enzymes of Streptomyces fradiae. Production, isolation, and preliminary characterization. (1967) (69)
Effectiveness of immunization with single and multi-component vaccines prepared from a common antigen (OEP), protease and elastase toxoids of Pseudomonas aeruginosa on protection against hemorrhagic pneumonia in mink due to P. aeruginosa. (1978) (61)
Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455 (1990) (58)
Trypsin as a catalyst for peptide synthesis. (1977) (56)
Peptide bond synthesis catalyzed by thermolysin. (1980) (55)
The specificities of various neutral and alkaline proteinases from microorganisms. (1967) (50)
Subtilisin BPN': kinetic study with oligopeptides. (1970) (50)
Achromobacter protease I-catalyzed conversion of porcine insulin into human insulin. (1980) (49)
Pseudomonas aeruginosa Elastase: Affinity Chromatography and Some Properties as a Metallo-neutral Proteinase (1975) (49)
Is the site of action of grayanotoxin the sodium channel gating of squid axon? (1985) (48)
Effects of protease and elastase from Pseudomonas aeruginosa on skin. (1975) (47)
Peptide Bond Synthesis Catalyzed by α-Chymotrypsin (1978) (47)
Elastolytic properties of various proteinases from microbial origin. (1967) (47)
The complex active sites of bacterial neutral proteases in relation to their specificities. (1968) (46)
Comparison of α-chymotrypsin and subtilisin BPN1: Size and specificity of the active site (1969) (45)
In vivo studies on protease and elastase from Pseudomonas aeruginosa. (1975) (45)
Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection (1993) (44)
Crystal structure of the unliganded alkaline protease from Pseudomonas aeruginosa IFO3080 and its conformational changes on ligand binding. (1995) (44)
Pseudolysin and other pathogen endopeptidases of thermolysin family. (1995) (43)
Proteolytic substrate specificity and some elastolytic properties of a thermostable bacterial proteinase. (1966) (42)
Comparison of the specificities of various serine proteinases from microorganisms. (1969) (41)
Peptide bond synthesis catalyzed by subtilisin, papain, and pepsin. (1981) (38)
Subtilisin BPN': inactivation by chloromethyl ketone derivates of peptide substrates. (1970) (36)
Coupling between Cbz-Arg-OH and Leu-X catalyzed by trypsin and papain. (1980) (36)
Specificity of Proteinase K from Tritirachium album Limber for Synthetic Peptides (1975) (33)
A kinetic investigation of subsites S1′ and S2′ in α-chymotrypsin and subtilisin BPN′ (1977) (32)
Comparison of various types of subtilisins: size and properties of the active site. (1971) (32)
Comparative specificity of microbial acid proteinases for synthetic peptides. 3. Relationship with their trypsinogen activating ability. (1973) (29)
On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides. (1973) (29)
The compound active site of Bacillus subtilis neutral protease: some properties of six subsites. (1969) (27)
A trypsin-like protease from Streptomyces fradiae. (1968) (27)
Influence of temperature on the enzymic semisynthesis of human insulin by coupling and transpeptidation methods. (1986) (27)
Pseudomonas aeruginosa proteinase. II. Molecular weight and molecular dimension. (1963) (26)
Phosphoramidon as an inhibitor of elastase from Pseudomonas aeruginosa. (1978) (26)
Effect of secondary interaction on the enzymatic activity of subtilisin BPN′: Comparison with α‐chymotrypsin, trypsin, and elastase (1973) (25)
On the Specificity of a Rennin-like Enzyme from Mucor pusillus (1973) (25)
PSEUDOMONAS AERUGINOSA PEPTIDE PEPTIDOHYDROLASE. 3. SOME CHARACTERS AS A CA2+-METALLOENZYME. (1964) (24)
Comparative study of various serine proteinases from microorganisms: specificity with oligopeptides. (1971) (23)
On the specificity of Bacillus subtilis neutral protease in relation to the compound active site. (1969) (22)
Comparative specificity of microbial acid proteinases for synthetic peptides. I. Primary specificity. (1973) (20)
Cloning and characterization of elastase structural gene from Pseudomonas aeruginosa IFO 3455. (1988) (19)
Comparative specificity of microbial acid proteinases for synthetic peptides. Primary specificity with Z-tetrapeptides. (1974) (19)
Detection of elastase production in Escherichia coli with the elastase structural gene from several non-elastase-producing strains of Pseudomonas aeruginosa (1991) (18)
Microbial degradation of proteins. (1992) (18)
Cloning and expression of the alkaline proteinase gene from Pseudomonas aeruginosa IFO 3455 (1989) (18)
Some physicochemical properties and substrate specificity of acid protease b of scytalidium lignicolum atcc 24568 (1975) (17)
Studies on the Protease of Pseudomonas (1957) (17)
Specificity of pepsin: Size and property of the active site (1970) (17)
Enzymatic synthesis of delta sleep-inducing peptide. (2009) (16)
Effect of secondary interaction on the enzymatic activity of trypsin-like enzymes from Streptomyces. (1973) (16)
Comparative specificity of microbial acid proteinases for synthetic peptides. II. Effect of secondary interaction. (1973) (16)
Some Physicochemical Properties and Substrate Specificities of Acid Proteases A-1 and A-2 of Scytalidium lignicolumn ATCC 24568 (1976) (15)
Comparative study of various neutral proteinases from microorganisms: specificity with oligopeptides. (1971) (15)
Pepstatin-insenstive acid proteases from Scytalidium lignicolum. Kinetic study with synthetic peptides. (1979) (15)
Distribution of Sarcophytol A in Soft Coral of the Sarcophyton Genus (2000) (15)
Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates. (1974) (15)
Enzymatic synthesis of cholecystokinin-octapeptide. (1988) (15)
Use of immobilized trypsin for semisynthesis of human insulin. (1989) (13)
Production of proteinase on noncarbohydrate carbon sources by Pseudomonas aeruginosa. (1965) (12)
Comparison of substrate specificities of a thermostable bacterial proteinase and a bacterial elastase. (1967) (12)
Kinetics of aspartame precursor synthesis catalysed by Pseudomonas aeruginosa elastase (2007) (12)
Proteolytic cleavage of exotoxin a form Pseudomonas aeruginosa (1980) (11)
Enzymatic semisynthesis of human insulin: An update (1990) (11)
PSEUDOMONAS AERUGINOSA PEPTIDE PEPTIDOHYDROLASE. IV. OPTICAL ROTATORY DISPERSION AND AMINO ACID COMPOSITION. (1964) (11)
Molecular Cloning and Partial DNA Sequencing of the Collagenase Gene of Vibrio alginolyticus (1990) (11)
Effect of Cobalt Ion on the Enzymatic Activity of Pseudomonas aeruginosa Alkaline Proteinase (1974) (11)
Immunoreactivity and Biologic Activity of Semisynthetic [LeuB30]-Insulin: Potential Value in the Treatment of Insulin Antibody-Mediated Insulin Resistance (1981) (10)
Dissection of the promoter/operator region and evaluation of N-acylhomoserine lactone mediated transcriptional regulation of elastase expression in Pseudomonas aeruginosa. (1997) (10)
Long-Range Effect of Mutation of Calcium Binding Asparates on the Catalytic Activity of Alkaline Protease from Pseudomonas aeruginosa (1998) (10)
Structural studies on anti-inflammatory polysaccharides from Streptomyces fradiae. (1974) (9)
Acyl and amino intermediates in reactions catalyzed by thermolysin. (1978) (9)
Thermolysin-catalyzed synthesis of peptide amides. (1988) (9)
Affinity purification of kallikrein and elastase from hog pancrease powder. (1986) (8)
New method of preparing elastase toxoid from Pseudomonas aeruginosa (1986) (7)
Proteolytic cleavage of exotoxin A from Pseudomonas aeruginosa: formation of an ADP-ribosyltransferase active fragment by the action of Pseudomonas elastase. (1980) (7)
Studies on the Protease of Pseudomonas :Part II. Crystallization of the Protease and its Physico-chemical and General Properties (1957) (7)
Substrate Specificities of the Proteases from a Marine-psychrophilic Bacterium, Pseudomonas sp. No. 548 (1974) (7)
Papain-catalyzed synthesis of aspartame precursor: A comparison with thermolysin (1998) (7)
Specificity of Proteinase K fromTritirachium albumLimber for Synthetic Peptides (1975) (6)
Alternative synthesis of the carboxyl terminal tetrapeptide amide of cholecystokinin by means of proteases (1987) (6)
Studies on the Protease of Pseudomonas :Part VIII. Proteinase Productions of Various Pseudomonas Species, Especially Ps. aeruginosa (1962) (6)
Long-range effect of mutation of calcium binding aspartates [correction of asparates] on the catalytic activity of alkaline protease from Pseudomonas aeruginosa. (1998) (6)
Comparison of the effects of a multi-component vaccine and a formalin-killed cell vaccine on protection against enzootic of hemorrhagic pneumonia due to Pseudomonas aeruginosa in mink. (1981) (6)
A new procedure for enzymatic semisynthesis of human insulin by hydrolysis of single-chain des-(b-30)-lnsulin precursor with lysyl endopeptidase. (1991) (5)
Use of Bacillus brevis for Synthesis and Secretion of Des-B30 Single-Chain Human Insulin Precursor (2000) (5)
Use of immobilized Achromobacter protease I for semisynthesis of human insulin. (1987) (5)
Elastase gene expression in non-elastase-producing Pseudomonas aeruginosa strains using novel shuttle vector systems. (1994) (4)
[Two metalloproteinases produced from Pseudomonas aeruginosa, especially on the structure of active site and substrate specificity]. (1992) (4)
Studies on the Protease of Pseudomonas: Part IV. Factors Affecting the Enzyme Production, Especially on the Effect of CalciumPart V. On the Role of Calcium in the Enzyme Production (1959) (4)
Protection against hemorrhagic pneumonia of mink by Pseudomonas aeruginosa multicomponent vaccine. (1979) (4)
Effects of proteases on the structure and activity of Pseudomonas aeruginosa exotoxin A (1981) (4)
Primary structure of Pseudomonas aeruginosa elastase. A comparison with thermolysin. (1989) (4)
Site-Directed Mutagenesis of His-176 and Glu-177 in Pseudomonas aeruginosa Alkaline Protease : Effect on Catalytic Activity (1997) (4)
Studies on the Protease of Pseudomonas :Part V. On the Role of Calcium in the Enzyme Production (1959) (3)
[Peptide bond synthesis catalyzed by various proteases (author's transl)]. (1981) (3)
Thermolysin catalyzed semisynthesis of peptide hormones by introduction of Phe-NH2 or Tyr-NH2 at the carboxyl termini. (1991) (3)
Comparison of alpha-chymotrypsin and subtilisin BPN': size and specificity of the active site. (1969) (2)
[Serralysin Zn-metalloproteinases--structure, function, secretion pathway, and pathogenicity]. (2000) (2)
[Enzymatic synthesis of peptides]. (1984) (2)
Peptide bond synthesis catalyzed by alpha-chymotrypsin. (1978) (2)
Elastase Activity of some Purified Proteinase Preparations as Related to their Depilatory Action (1965) (2)
Aspartame precursor synthesis in water miscible cosolvent catalysed by thermolysin (1992) (2)
Studies on the Protease of Pseudomonas :Part I. The Production of the Enzyme under Various Cultural Conditions (1956) (1)
Studies on the Protease of Pseudomonas :Part VII. An Immunological Study of the Crystalline Proteinase (1960) (1)
A chloroacetyl peptide derivative as an inhibitor of thiol proteinases. (1985) (1)
Studies on the Protease of Pseudomonas: Part III. Specific Action of the Protease (1957) (1)
Signal peptidase cleavage site in the processing of Pseudomonas aeruginosa preproelastase (1994) (1)
Process for the preparation of human insulin (1980) (1)
A kinetic investigation of subsites S1' and S2' in alpha-chymotrypsin and subtilisin BPN'. (1977) (1)
Inactivation of papain with chloroacetyl amino acid derivatives. (1986) (1)
PRODUCTIONOF ELASTASEAND PROTEINASEBY PSEUDOMONAS AERUGINOSA (1964) (0)
PEPTIDE SYNTHESIS USING ENZYME AS SYNTHETIC CATALYST. SYNTHESIS OF NEW WATER-SOLUBLE ESTER SUBSTRATES AND ENZYME IMMOBILIZATION (1984) (0)
Acid Carboxypeptidase-like Activity Contaminating Proctase B (1973) (0)
[Acid proteases (author's transl)]. (1977) (0)
[Bacterial intercellular communication and environmental adaptation]. (2000) (0)
Crystal Structure of Alkaline Protease from Pseudomonas Aeruginosa IFO3455 (1994) (0)
Milk-clotting or Blood-coagulating Activities of Some Proteinases and their Substrate Specificities (1965) (0)
Elastolytic Activities of Various Microbial Proteinases and their Proteolytic Substrate Specificities (1967) (0)
ALKALINE PROTEASE FROM PSEUDOMONAS AERUGINOSA IFO3080 (1996) (0)
Studies on the Protease of Pseudomonas :Part VI. On the Role of Ca in the Enzyme Production (supplemented) (1960) (0)
United States Patent ( 19 Morihara et al . 54 SEMI-SYNTHESIS OF HUMAN INSULIN (2017) (0)
Enzymatic semisynthesis of human insulin. (1986) (0)
Use of Bacntus brevts for Synthesis Human Insulin Precursor andSecretion of Des-B 30 Single-Chain (2017) (0)
Enzymatic semisynthesis of [Leu B30] insulin (2009) (0)
Enzymatic semisynthesis of [LeuB30] insulin. (1986) (0)
A process for preparing oeb30-Thr (R 1) (R 2) aa - insulin (1981) (0)
Studies on the protease of Pseudomonas,pt.6,7. (1960) (0)
Production ofProteinase on Noncarbohydrate Carbon Sources byPseudomonas aeruginosa (1965) (0)
Effects of methanol on the synthesis of aspartame precursor catalysed byPseudomonas aeruginosa elastase (1992) (0)
[Binding sites of subtilisin]. (1972) (0)
Purification of Aspergillus oryzae Acid Proteinase: Contamination with Acid Carboxypeptidase-like Activity (1973) (0)
Enzymatic Synthesis of Cholecystokinin-octapeptide1) (2010) (0)
Y Pseudomonas aeruginosa . several non-elastase-producing strains of coli with the elastase structural gene from Detection of elastase production in Escherichia (0)

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