Karl Tryggvason

Q: What Schools Are Affiliated With Karl Tryggvason

Karl Tryggvason is affiliated with the following schools: University of California, Berkeley, University of California, San Diego, Stanford University, Lund University, Karolinska Institute, University of Oulu

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Karl Tryggvason

Engineering

#2800

World Rank

#3779

Historical Rank

Biomedical Engineering

#91

World Rank

#92

Historical Rank

Applied Physics

#404

World Rank

#420

Historical Rank

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Engineering

Karl Tryggvason's Degrees

PhD Bioengineering University of California, San Diego
Masters Mechanical Engineering University of California, Berkeley

Why Is Karl Tryggvason Influential?

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According to Wikipedia, Karl Tryggvason is an Icelandic medical researcher. Karl Tryggvason was born in Reykjavik. He trained as a medical doctor at Finland's University of Oulu, where he graduated with an M.D. in 1975 and with a Ph.D. in 1977 with doctoral dissertation Glomeruli and their basement membrane in the normal human kidney and in congenital nephrotic syndrome of the Finnish type. At the University of Oulu for the academic years from 1974 to 1978 and in 1979, he was an assistant in the medical biochemistry department. For the academic year 1978–1979 he was a visiting associate at the NIH's National Institute of Dental Research in Bethesda, Maryland. For the academic year 1979–1980 he was an assistant of clinical chemistry in the resident program of the University Hospital of Oulu. For the academic year 1983–1984 he was a visiting associate professor of biochemistry and clinical pathology at Rutgers New Jersey Medical School. From 1986 to 1989 he was a senior investigator in the Academy of Finland. From 1987 to 1995 he was a professor of biochemistry and chair of the biochemistry department of the University of Oulu's Faculty of Science — during those year he was also from 1989 to 1994 a research professor at The Finnish Cancer Institute . Karl Tryggvason was appointed in 1994 a professor of medical chemistry in the Karolinska Institute's Department of Biochemistry and Biophysics and in 2012 the Tanoto Professor in Diabetes Research at Singapore's Duke–NUS Medical School. He is a member of the Nobel Assembly at the Karolinska Institute as a member of the Nobel Committee for physiology and medicine. He was in 1986 one of the founders of Biocenter Oulu, Finland's first elite center in biomedical research, which became a biomedical research model for other Finnish universities.

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Karl Tryggvason's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Metastatic potential correlates with enzymatic degradation of basement membrane collagen (1980) (1829)
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. (1998) (1818)
Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. (1982) (1244)
A simplified laminin nomenclature. (2005) (849)
Alport's syndrome, Goodpasture's syndrome, and type IV collagen. (2003) (843)
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. (2000) (828)
Identification of mutations in the COL4A5 collagen gene in Alport syndrome. (1990) (776)
Nephrin is specifically located at the slit diaphragm of glomerular podocytes. (1999) (713)
Genomic instability in laminopathy-based premature aging (2005) (624)
Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. (1993) (602)
Hereditary proteinuria syndromes and mechanisms of proteinuria. (2006) (548)
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice (2002) (526)
The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. (2001) (522)
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages (1995) (517)
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511 (2010) (516)
Proteolytic degradation of extracellular matrix in tumor invasion. (1987) (504)
Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. (1999) (488)
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. (2006) (488)
Mutations in the laminin α2–chain gene (LAMA2) cause merosin–deficient congenital muscular dystrophy (1995) (460)
X-linked Alport syndrome: natural history in 195 families and genotype- phenotype correlations in males. (2000) (459)
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation (2005) (455)
Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. (1995) (420)
Structure of the gene for congenital nephrotic syndrome of the finnish type (NPHS1) and characterization of mutations. (1999) (394)
Laminin isoforms in tumor invasion, angiogenesis and metastasis. (2002) (372)
X-linked Alport syndrome: natural history and genotype-phenotype correlations in girls and women belonging to 195 families: a "European Community Alport Syndrome Concerted Action" study. (2003) (370)
The Scavenger Receptor MARCO Is Required for Lung Defense against Pneumococcal Pneumonia and Inhaled Particles (2004) (363)
Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization. (1992) (358)
Identification of a distinct type IV collagen alpha chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome. (1990) (351)
Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells. (1991) (343)
Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the γ2 subunit of nicein/kalinin (LAMININ–5) (1994) (332)
Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer. (1993) (308)
The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers. (1994) (305)
Mutations in the γ2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa (1994) (302)
Structure of the human type IV collagenase gene. (1990) (298)
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography. (2004) (298)
Functional diversity of laminins. (2012) (297)
Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm. (1999) (290)
MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis (2009) (290)
Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation (2002) (283)
High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development (1994) (280)
Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo. (1999) (274)
Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration. (2002) (269)
Congenital nephrotic syndrome (NPHS1): features resulting from different mutations in Finnish patients. (2000) (265)
Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues (1994) (260)
Role of the Scavenger Receptor MARCO in Alveolar Macrophage Binding of Unopsonized Environmental Particles (1999) (253)
Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment (2014) (251)
Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. (2001) (251)
New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes (2012) (250)
A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment (1992) (246)
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney (2003) (243)
Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor (1992) (239)
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. (1995) (234)
Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase. (1989) (230)
Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors. (1993) (229)
Purification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells. (1983) (228)
Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain (2009) (225)
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs (2002) (221)
Large‐scale identification of genes implicated in kidney glomerulus development and function (2006) (215)
Partial purification and characterization of a neutral protease which cleaves type IV collagen. (1981) (214)
MARCO Is the Major Binding Receptor for Unopsonized Particles and Bacteria on Human Alveolar Macrophages1 (2005) (211)
Impaired Angiogenesis, Delayed Wound Healing and Retarded Tumor Growth in Perlecan Heparan Sulfate-Deficient Mice (2004) (203)
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 (2002) (203)
Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells – role in metastasis (1982) (196)
Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development. (1992) (192)
Properly formed but improperly localized synaptic specializations in the absence of laminin α4 (2001) (191)
The macrophage receptor MARCO. (2000) (187)
Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome (2001) (182)
New insights into the role of podocytes in proteinuria (2009) (176)
cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain. (1985) (173)
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. (2012) (171)
Deletion of the laminin alpha4 chain leads to impaired microvessel maturation. (2002) (170)
The laminin family. (1993) (170)
Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. (2002) (170)
Structure of the Human Macrophage MARCO Receptor and Characterization of Its Bacteria-binding Region* (1998) (165)
Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator. (1992) (164)
Laminin‐511 but Not ‐332, ‐111, or ‐411 Enables Mouse Embryonic Stem Cell Self‐Renewal In Vitro (2008) (163)
CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere. (2000) (159)
Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin. (2002) (157)
Laminin-5 as a marker of invasiveness in cervical lesions. (1999) (157)
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice (2008) (157)
Nephrin--a unique structural and signaling protein of the kidney filter. (2007) (151)
Nephrin promotes cell-cell adhesion through homophilic interactions. (2003) (149)
Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase. (1984) (149)
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. (2011) (143)
Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome. (2001) (143)
Congenital nephrotic syndrome of the Finnish type maps to the long arm of chromosome 19. (1994) (140)
Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins. (2006) (137)
Molecular genetics of Alport syndrome. (1993) (137)
Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7. (1987) (135)
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. (2005) (135)
Recombinant Laminin-8 (α4β1γ1) (2000) (132)
Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain. (1997) (132)
Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo (2011) (132)
Complete amino acid sequence of the human alpha 5 (IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in an Alport syndrome patient. (1992) (131)
Biosynthesis of type IV procollagens. (1980) (131)
92‐kDa type IV collagenase and TIMP‐3, but not 72‐kDa type IV collagenase or TIMP‐1 or TIMP‐2, are highly expressed during mouse embryo implantation (1995) (130)
Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells. (2002) (128)
Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. (2007) (128)
Type IV collagenases in invasive tumors (2005) (127)
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus (2007) (127)
Role of nephrin in cell junction formation in human nephrogenesis. (2000) (127)
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. (2003) (126)
High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing. (1998) (126)
Molecular make-up of the glomerular filtration barrier. (2010) (123)
Primary structure and expression of a novel human laminin α4 chain (1995) (122)
How does the kidney filter plasma? (2005) (122)
The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain. (1988) (121)
Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases. (2003) (119)
Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains. (1988) (117)
Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors. (1993) (116)
X-linked Alport syndrome: an SSCP-based mutation survey over all 51 exons of the COL4A5 gene. (1996) (114)
SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. (2011) (113)
Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure (2003) (110)
Membrane Type 1-Matrix Metalloproteinase Is Regulated by Chemokines Monocyte-Chemoattractant Protein-1/CCL2 and Interleukin-8/CXCL8 in Endothelial Cells during Angiogenesis* (2005) (110)
Macrophage scavenger receptor MARCO: in vitro and in vivo regulation and involvement in the anti-bacterial host defense. (1997) (108)
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region. (1988) (107)
Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome. (1996) (106)
Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane. (2009) (105)
A Site on Laminin α5, AQARSAASKVKVSMKF, Induces Inflammatory Cell Production of Matrix Metalloproteinase-9 and Chemotaxis1 (2003) (103)
N-linked glycosylation is critical for the plasma membrane localization of nephrin. (2002) (102)
Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues. (1994) (102)
Heparan sulfate of perlecan is involved in glomerular filtration. (2005) (102)
Primary structure of the human laminin A chain. Limited expression in human tissues. (1991) (101)
Expression of nephrin in pediatric kidney diseases. (2001) (101)
Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains. (1994) (100)
Heparan Sulfate in Perlecan Promotes Mouse Atherosclerosis: Roles in Lipid Permeability, Lipid Retention, and Smooth Muscle Cell Proliferation (2008) (100)
Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro (2008) (99)
Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome. (2003) (98)
Single base mutation in alpha 5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome. (1991) (95)
Nck Links Nephrin to Actin in Kidney Podocytes (2006) (94)
Alport syndrome and diffuse leiomyomatosis: deletions in the 5' end of the COL4A5 collagen gene. (1992) (93)
Impeded Interaction between Schwann Cells and Axons in the Absence of Laminin α4 (2005) (93)
Increased Intimal Hyperplasia and Smooth Muscle Cell Proliferation in Transgenic Mice With Heparan Sulfate–Deficient Perlecan (2004) (92)
Primary Structure, Developmental Expression, and Immunolocalization of the Murine Laminin α4 Chain* (1997) (91)
Localization of Laminin α4-Chain in Developing and Adult Human Tissues (2002) (90)
MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis (2006) (90)
Tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane (type IV) collagen-degrading metalloproteinase by human fibroblasts. (1985) (90)
Monolayer culturing and cloning of human pluripotent stem cells on laminin-521–based matrices under xeno-free and chemically defined conditions (2014) (89)
Contributions of the LG Modules and Furin Processing to Laminin-2 Functions* (2002) (89)
Crystal Structure of the Cysteine-rich Domain of Scavenger Receptor MARCO Reveals the Presence of a Basic and an Acidic Cluster That Both Contribute to Ligand Recognition* (2007) (89)
Substitution of a conserved cysteine-996 in a cysteine-rich motif of the laminin alpha2-chain in congenital muscular dystrophy with partial deficiency of the protein. (1996) (88)
Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene. (2000) (88)
Altered distribution and synthesis of laminin‐5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas (1997) (88)
Autolytic activation of recombinant human 72 kilodalton type IV collagenase. (1995) (88)
Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q. (2007) (87)
Stability analysis of latent and active 72-kDa type IV collagenase: the role of tissue inhibitor of metalloproteinases-2 (TIMP-2). (1993) (86)
Deletions of both α5(IV) and α6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours (1995) (86)
Complete primary structure of the α1‐chain of human basement membrane (type IV) collagen (1987) (85)
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution. (1998) (85)
Modulation of type‐iv collagenase activity and invasive behavior of metastatic human melanoma (A2058) cells in vitro by monoclonal antibodies to type‐iv collagenase (1990) (85)
Defective trafficking of nephrin missense mutants rescued by a chemical chaperone. (2004) (84)
Deletions in the COL4A5 collagen gene in X-linked Alport syndrome. Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression. (1994) (83)
EXPRESSION OF THE LAMININ γ2 CHAIN IN PANCREATIC ADENOCARCINOMA (1996) (83)
Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of α5-laminin(s) and α3β1 integrin (2007) (82)
Defective Microarchitecture of the Spleen Marginal Zone and Impaired Response to a Thymus-Independent Type 2 Antigen in Mice Lacking Scavenger Receptors MARCO and SR-A1 (2005) (82)
Simultaneous expression of 70 kilodalton type IV collagenase and type IV collagen alpha 1 (IV) chain genes by cells of early human placenta and gestational endometrium. (1992) (82)
The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases. (2006) (81)
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. (2007) (81)
Structure of the human type IV collagen COL4A5 gene. (1994) (81)
Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy (2012) (81)
Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice (2011) (80)
Characterization of Recombinant Soluble Macrophage Scavenger Receptor MARCO* (2002) (80)
Cardiomyopathy Associated with Microcirculation Dysfunction in Laminin α4 Chain-deficient Mice* (2006) (78)
A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. (2009) (77)
Substitution of arginine for glycine 325 in the collagen alpha 5 (IV) chain associated with X-linked Alport syndrome: characterization of the mutation by direct sequencing of PCR-amplified lymphoblast cDNA fragments. (1992) (75)
Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO. (2002) (75)
Expression of nephrin in acquired human glomerular disease. (2002) (74)
Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages. (1999) (73)
Laminin-5 promotes adhesion and migration of epithelial cells: identification of a migration-related element in the gamma2 chain gene (LAMC2) with activity in transgenic mice. (1999) (73)
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis (2006) (72)
Laminin-8 (alpha4beta1gamma1) is synthesized by lymphoid cells, promotes lymphocyte migration and costimulates T cell proliferation. (2001) (71)
Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations (2002) (71)
Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane. (2004) (70)
Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16. (1990) (70)
An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis (2004) (69)
Fine mapping and haplotype analysis of the locus for congenital nephrotic syndrome on chromosome 19q13.1. (1995) (69)
Laminin-5 γ2 Chain Expression Correlates with Unfavorable Prognosis in Colon Carcinomas (2001) (67)
Blood Platelets Contain and Secrete Laminin-8 (α4β1γ1) and Adhere to Laminin-8 via α6β1 Integrin (1999) (67)
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. (2006) (66)
Monoclonal antibodies to human prolyl 4-hydroxylase. (1984) (66)
Monocytic Cells Synthesize, Adhere to, and Migrate on Laminin-8 (α4β1γ1)1 (2000) (65)
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis. (2012) (65)
Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin. (2007) (65)
Characterization of the interactions of the nephrin intracellular domain (2004) (64)
Scavenger Receptors SR-AI/II and MARCO Limit Pulmonary Dendritic Cell Migration and Allergic Airway Inflammation1 (2007) (64)
Structure of the Human Laminin α2-Chain Gene (LAMA2), Which Is Affected in Congenital Muscular Dystrophy* (1996) (63)
A regulatory role for macrophage class A scavenger receptors in TLR4‐mediated LPS responses (2010) (63)
Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells. (2007) (62)
Genetics of laminin α2 chain (or merosin) deficient congenital muscular dystrophy: from identification of mutations to prenatal diagnosis (1997) (62)
Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes. (2013) (62)
Laminins in Cellular Differentiation. (2019) (62)
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow (2008) (61)
Characterization of the 3' half of the human type IV collagen alpha 5 gene that is affected in the Alport syndrome. (1991) (61)
Expression of the laminin γ2 chain in different histological types of lung carcinoma. A study by immunohistochemistry and in situ hybridization (1999) (60)
Structural organization of the gene for the alpha 1 chain of human type IV collagen. (1989) (60)
Expression of Macrophage MARCO Receptor Induces Formation of Dendritic Plasma Membrane Processes* (1999) (60)
Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology (2011) (59)
Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells. (2007) (59)
Molecular Cloning and Tissue-specific Expression of a Novel Murine Laminin γ3 Chain* (1999) (58)
Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis. (1999) (57)
Recombinant laminin-8 (alpha(4)beta(1)gamma(1)). Production, purification,and interactions with integrins. (2000) (57)
Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin. (2003) (57)
Nephrin is involved in podocyte maturation but not survival during glomerular development. (2008) (56)
High Expression of 92‐kDa Type IV Collagenase (Gelatinase) in the Osteoclast Lineage during Mouse Development (1994) (56)
Towards understanding the inherited susceptibility for nephropathy in diabetes (2012) (55)
PCR based mutation screening of the laminin alpha2 chain gene (LAMA2): application to prenatal diagnosis and search for founder effects in congenital muscular dystrophy. (1998) (55)
Adenovirus-mediated transfer of type IV collagen α5 chain cDNA into swine kidney in vivo: deposition of the protein into the glomerular basement membrane (2001) (55)
Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance. (2007) (54)
Thin basement membrane nephropathy. (2006) (54)
Structure of the human laminin gamma 2 chain gene (LAMC2): alternative splicing with different tissue distribution of two transcripts. (1996) (53)
The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene. (1995) (53)
Association between the expression of murine 72 kDa type IV collagenase by odontoblasts and basement membrane degradation during mouse tooth development. (1992) (52)
Components of subendothelial aorta basement membrane. Immunohistochemical localization and role in cell attachment. (1983) (52)
Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism. (1991) (52)
Congenital nephrotic syndromes. (2001) (52)
Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors. (2011) (51)
Mutation in the alpha 5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss or ocular lesions: detection by denaturing gradient gel electrophoresis of a PCR product. (1992) (51)
Deletion of Laminin-8 Results in Increased Tumor Neovascularization and Metastasis in Mice (2004) (50)
Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex. (1977) (50)
Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (α2β1γ1), 8 (α4β1γ1), 10 (α5β1γ1) (2006) (49)
Loss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas. (1997) (48)
Structure of the human laminin B1 chain gene. (1990) (48)
Murine Matrix Metalloproteinase 9 Gene (1999) (47)
COL4A5 deletions in three patients with Alport syndrome and posttransplant antiglomerular basement membrane nephritis. (1994) (47)
Expression of the laminin gamma 2 chain in pancreatic adenocarcinoma. (1996) (47)
Directional regulatory activity of cis-acting elements in the bidirectional alpha 1(IV) and alpha 2(IV) collagen gene promoter. (1993) (46)
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes (2014) (46)
Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon. (1988) (45)
Localization of laminin alpha4-chain in developing and adult human tissues. (2002) (45)
Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: a study of 250 patients with hematuria and suspected of having Alport syndrome. (1996) (45)
Different mutations in the COL4A5 collagen gene in two patients with different features of Alport syndrome. (1992) (45)
Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic mice (2003) (45)
The podocyte protein nephrin is required for cardiac vessel formation. (2011) (45)
Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene. (1991) (44)
Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline. (1977) (43)
SR-A, MARCO and TLRs Differentially Recognise Selected Surface Proteins from Neisseria meningitidis: an Example of Fine Specificity in Microbial Ligand Recognition by Innate Immune Receptors (2008) (43)
Number of nephrons in normal human kidneys and kidneys of patients with the congenital nephrotic syndrome. A study using a sieving method for counting of glomeruli. (1975) (42)
Differentiation of Human Embryonic Stem Cells to Endothelial Progenitor Cells on Laminins in Defined and Xeno-free Systems (2016) (42)
Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis. (2007) (42)
Mutations in type IV collagen genes and Alport phenotypes. (1996) (42)
Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. (2013) (42)
Genotype / phenotype correlations of NPHS 1 and NPHS 2 mutations in nephrotic syndrome advocate a functional interrelationship in glomerular filtration (2002) (41)
Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release (2009) (41)
Tissue Expression of Nephrin in Human and Pig (2004) (41)
Heterogeneity of pepsin-solubilized human glomerular basement membrane collagen. (1978) (40)
An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis. (2004) (40)
Evidence for the existence of multiple heparan sulfate proteoglycans in the human glomerular basement membrane and mesangial matrix. (1997) (39)
The glomerular transcriptome and a predicted protein-protein interaction network. (2008) (39)
Ulcerative colitis and colorectal carcinoma: DNA-profile, laminin-5 gamma2 chain and cyclin A expression as early markers for risk assessment. (2001) (39)
Podocyte proteins in Galloway-Mowat syndrome (2001) (39)
Laminin α4 Deficient Mice Exhibit Decreased Capacity for Adipose Tissue Expansion and Weight Gain (2014) (39)
Stem cell therapy for Alport syndrome: the hope beyond the hype. (2008) (38)
Glcci1 deficiency leads to proteinuria. (2011) (38)
Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue (2006) (38)
Deletions of the COL4A5 gene in patients with Alport syndrome. (1992) (38)
Improved prenatal diagnosis of the congenital nephrotic syndrome of the Finnish type based on DNA analysis. (1997) (38)
Deficiency of a Transmembrane Prolyl 4-Hydroxylase in the Zebrafish Leads to Basement Membrane Defects and Compromised Kidney Function* (2010) (37)
Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney. (1999) (37)
Identification of N-linked glycosylation sites in human nephrin using mass spectrometry. (2007) (37)
Monocytic cells synthesize, adhere to, and migrate on laminin-8 (alpha 4 beta 1 gamma 1). (2000) (37)
Human alpha 1 (XIII) collagen gene. Multiple forms of the gene transcripts are generated through complex alternative splicing of several short exons. (1991) (36)
Primary structure and expression of a novel human laminin alpha 4 chain. (1995) (36)
Podocin-green fluorescence protein allows visualization and functional analysis of podocytes. (2011) (35)
Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function (2007) (34)
Biochemical mechanisms involved in tumor cell penetration of the basement membrane (1982) (34)
Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin β1 and γ1 chains (2000) (34)
Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information (2017) (34)
A systematic approach to the development of a safe live attenuated Zika vaccine (2018) (34)
Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes. (2008) (33)
Ab initio solution of macromolecular crystal structures without direct methods (2017) (33)
Partial purification and characterization of chick-embryo prolyl 3-hydroxylase. (1979) (33)
Mutations in the codon for a conserved arginine-1563 in the COL4A5 collagen gene in Alport syndrome. (1993) (33)
Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration. (2015) (32)
Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development (2011) (32)
Amino acid transporter LAT3 is required for podocyte development and function. (2009) (31)
Quantitation of basement membrane collagen degradation by living tumor cells in vitro. (1980) (30)
Glomerular Transcriptome Changes Associated with Lipopolysaccharide-Induced Proteinuria (2009) (30)
Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis. (1996) (30)
Delayed Tooth Eruption in Membrane Type-1 Matrix Metalloproteinase Deficient Mice (2003) (30)
A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO* (2006) (30)
Chondroitin sulphate modification in the α4 chain of human recombinant laminin-8 (α4β1γ1) (2002) (30)
Assessment of 72-kilodalton gelatinase and TIMP-1 gene expression in normal and sclerotic murine glomeruli. (1994) (30)
Pdlim2 is a novel actin-regulating protein of podocyte foot processes. (2011) (29)
Expression and characterization of human perlecan domains I and II synthesized by baculovirus-infected insect cells. (1996) (29)
Laminin isoforms of lymph nodes and predominant role of α5‐laminin(s) in adhesion and migration of blood lymphocytes (2008) (29)
Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. (1999) (28)
Association of genetic variants at 3q22 with nephropathy in patients with type 1 diabetes mellitus. (2009) (28)
Can Alport syndrome be treated by gene therapy? (1997) (27)
Lmx1b and FoxC combinatorially regulate podocin expression in podocytes. (2014) (27)
Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome. (2018) (27)
Dexamethasone modulates the metabolism of type IV collagen and fibronectin in human basement-membrane-forming fibrosarcoma (HT-1080) cells. (1987) (27)
Structure and expression of type IV collagenase genes. (1990) (27)
In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors. (2019) (27)
Expression of the laminin gamma2 chain in different histological types of lung carcinoma. A study by immunohistochemistry and in situ hybridization. (1999) (27)
Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome (2009) (26)
Blood platelets contain and secrete laminin-8 (alpha4beta1gamma1) and adhere to laminin-8 via alpha6beta1 integrin. (1999) (26)
Identification of four novel mutations in the COL4A5 gene of patients with Alport syndrome. (1993) (26)
Wound healing in membrane-type-1 matrix metalloproteinase-deficient mice. (2004) (26)
COL4A5 splice site mutation and α5(IV) collagen mRNA in Alport syndrome (1993) (26)
Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1 (1998) (26)
Human laminin B2 chain (1988) (26)
Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (alpha2beta1gamma1), 8 (alpha4beta1gamma1), 10 (alpha5beta1gamma1). (2006) (26)
Detection of Novel LAMC2 Mutations in Herlitz Junctional Epidermolysis Bullosa (1997) (26)
High-affinity monoclonal antibodies specific for human prostatic acid phosphatase. (1987) (25)
Sera from patients with anti-GBM nephritis including Goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen α chains (1996) (25)
Human embryonic stem cells. (2016) (25)
RECOMBINANT HUMAN LAMININ-10 ( α 5 β 1 γ 1 ) : Production , Purification and Migration Promoting Activity on Vascular Endothelial Cells (2002) (25)
Detection of 12 novel mutations in the collagenous domain of the COL4A5 gene in Alport syndrome patients (1995) (25)
Myo1e Impairment Results in Actin Reorganization, Podocyte Dysfunction, and Proteinuria in Zebrafish and Cultured Podocytes (2013) (24)
Identification of post-transplant anti-alpha 5(IV) collagen alloantibodies in X-linked Alport syndrome (1996) (24)
Concise Review: Animal Substance‐Free Human Embryonic Stem Cells Aiming at Clinical Applications (2014) (24)
Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome. (2008) (24)
Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25----q31. (1988) (24)
Assignment of the gene coding for both the beta-subunit of prolyl 4-hydroxylase and the enzyme disulfide isomerase to human chromosome region 17p11----qter. (1988) (23)
Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy (2013) (23)
Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture (2018) (23)
Animal Models of Alport Syndrome: Advancing the Prospects for Effective Human Gene Therapy (2000) (23)
Effects of streptozotocin diabetes, glucose, and insulin on the metabolism of type IV collagen and proteoglycan in murine basement membrane-forming EHS tumor tissue. (1982) (23)
Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen. (1986) (22)
Unraveling the Molecular Make-Up of the Glomerular Podocyte Slit Diaphragm (2001) (22)
Effect of hepatic injury on prolyl 3-hydroxylase and 4-hydroxylase activities in rat liver and on immunoreactive prolyl 4-hydroxylase concentrations in the liver and serum. (1978) (22)
Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice. (2018) (22)
Effects of laminin, proteoglycan and type IV collagen, components of basement membranes, on platelet aggregation. (1981) (21)
Exclusion of eight genes as mutated loci in congenital nephrotic syndrome of the Finnish type. (1994) (21)
Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics. (2012) (21)
Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen. (1987) (21)
Differential expression of mouse laminin γ2 and γ2* chain transcripts (2000) (21)
Antibodies to collagenase‐resistant terminal regions of pro‐type IV collagen recognize whole basement membrane and 7 S collagen (1981) (21)
Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type (2006) (21)
Antibodies blocking adhesion and matrix binding domains of laminin‐332 inhibit tumor growth and metastasis in vivo (2009) (21)
Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria (2010) (20)
Nucleotide sequence coding for the human type IV collagen α2 chain cDNA reveals extensive homology with the NC‐1 domain of α1 (IV) but not with the collagenous domain or 3 untranslated region (1987) (20)
Molecular pathology and genetics of Alport syndrome (1996) (20)
Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification (2014) (19)
Extensive structural differences between genes for the α1 and α2 chains of type IV collagen despite conservation of coding sequences (1987) (19)
Assignment of the human collagen α1(XIII) chain gene (COL13A1) to the q22 region of chromosome 10 (1989) (19)
Erythromegakaryocytic Cells Synthesize Laminin-8 (α4β1γ1) (2000) (19)
A rapid assay for prolyl 3-hydroxylase activity. (1978) (19)
Molecular properties and diseases of collagens. (1995) (19)
Laminin-8 ( α 4 β 1 γ 1 ) is synthesized by lymphoid cells , promotes lymphocyte migration and costimulates T cell proliferation (18)
Prolyl 3-hydroxylase and 4-hydroxylase activities in certain rat and chick-embryo tissues and age-related changes in their activities in the rat. (1979) (18)
Dendrin ablation prolongs life span by delaying kidney failure. (2015) (18)
Megakaryocytic cells synthesize and platelets secrete α5-laminins, and the endothelial laminin isoform laminin 10 (α5β1γ1) strongly promotes adhesion but not activation of platelets (2005) (18)
Biosynthesis of type IV and V (alpha A-alpha B) collagens by human placenta. (1981) (18)
Recombinant laminin B1 chains exhibit intact short-arm domains but do not form oligomeric molecules. (1992) (17)
A novel surgical organ perfusion method for effective ex vivo and in vivo gene transfer into renal glomerular cells (1999) (17)
COL4A6 is dispensable for autosomal recessive Alport syndrome (2016) (17)
Laminin-5 &ggr; 2 chain as an invasivity marker for uni- and multifocal lesions in the lower anogenital tract (2002) (17)
Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice. (2013) (17)
Sera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains. (1996) (17)
Megakaryocytic cells synthesize and platelets secrete alpha5-laminins, and the endothelial laminin isoform laminin 10 (alpha5beta1gamma1) strongly promotes adhesion but not activation of platelets. (2006) (16)
Plasminogen activators and steroid receptor concentrations in normal, benign, and malignant breast and ovarian tissues. (1983) (16)
Two novel alternatively spliced 9-bp exons in the COL4A5 gene (2001) (16)
Congenital nephrotic syndrome of the Finnish type is not associated with the Pax-2 gene despite the promising transgenic animal model. (1994) (16)
Haplotype analysis of congenital nephrotic syndrome of the Finnish type in non-Finnish families. (1996) (16)
Laminin 5 γ2 chain expression: a marker of early invasiveness in colorectal adenomas (2003) (16)
Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells (2016) (16)
Laminin-5 γ2-chain expression and DNA ploidy as predictors of prognosis in endometrial carcinoma (2003) (15)
The Glomerular Transcriptome and Proteome (2007) (15)
Collagenolytic enzymes in periodontal diseases. (1987) (15)
A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation (2016) (14)
Pathology of glomerular basement membrane nephropathy. (1994) (14)
Sp1 Specifically Binds to an Evolutionarily Conserved DNA Segment within a Region Necessary for Podocyte-Specific Expression of Nephrin (2009) (13)
Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin beta1 and gamma1 chains. (2000) (13)
Neph1 Is Reduced in Primary Focal Segmental Glomerulosclerosis, Minimal Change Nephrotic Syndrome, and Corresponding Experimental Animal Models of Adriamycin-Induced Nephropathy and Puromycin Aminonucleoside Nephrosis (2014) (13)
Morphometric studies on glomeruli in the congenital nephrotic syndrome. (1978) (13)
A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome. (1995) (12)
Permeability, Ultrastructural Changes, and Distribution of Novel Proteins in the Glomerular Barrier in Early Puromycin Aminonucleoside Nephrosis (2010) (12)
70 K type IV collagenase (gelatinase). (1992) (12)
The single copy gene coding for human α1 (IV) procollagen is located at the terminal end of the long arm of chromosome 13 (1986) (12)
Degradation of proinsulin C-peptide in kidney and placenta extracts by a specific endoprotease activity (2004) (12)
Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin (2015) (12)
Gain of chromosome 3q is an early and consistent genetic aberration in carcinomas of the vulva (2004) (12)
Monoclonal antibodies to human nephrin. (2004) (12)
Perlecan heparan sulfate proteoglycan is a critical determinant of angiogenesis in response to mouse hind-limb ischemia. (2014) (12)
Chondroitin sulphate modification in the alpha4 chain of human recombinant laminin-8 (alpha4beta1gamma1). (2002) (11)
The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen (2019) (11)
The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy‐terminus of the protein. (1986) (11)
Laminin 5 gamma 2 chain expression: a marker of early invasiveness in colorectal adenomas. (2003) (11)
Erratum: Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography (Journal of Clinical Investigation (2004) 114 (1475-1483)(doi: 10.1172/JCI200422562)) (2004) (11)
Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury. (2014) (10)
Human Mast Cells Adhere to and Migrate on Epithelial and Vascular Basement Membrane Laminins LM-332 and LM-511 via α3β1 Integrin1 (2009) (10)
Knocking out podocyte rho GTPases: and the winner is... (2012) (10)
Chemically defined and xenogeneic-free culture method for human epidermal keratinocytes on laminin-based matrices (2020) (10)
Chromosome 2 q 31 . 1 Associates with ESRD in Women with Type 1 Diabetes (2013) (10)
Contribution of (cid:1) 6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with (cid:1) 4 integrins (2006) (10)
Laminin-5 γ2 Chain Expression Facilitates Detection of Invasive Squamous Cell Carcinoma of the Uterine Cervix (2004) (10)
Searching for a treatment for Alport syndrome using mouse models. (2014) (9)
Supplemental Information MT 1-MMP Inactivates ADAM 9 to Regulate FGFR 2 Signaling and Calvarial Osteogenesis (2012) (9)
Critical Role of Lama4 for Hematopoiesis Regeneration and Acute Myeloid Leukemia Progression. (2021) (9)
Studies on the molecular composition and degradation of type IV procollagen. (1984) (9)
Extracellular Matrix and Its Enzymatic Degradation in Tumor Invasion (1989) (9)
Differential expression of mouse laminin gamma2 and gamma2* chain transcripts. (2000) (9)
Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice (2004) (9)
Nephrin: role in normal kidney and in disease. (2001) (8)
A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland (2007) (8)
High-density genetic and physical mapping of DNA markers near the X-linked Alport syndrome locus: definition and use of flanking polymorphic markers (1991) (8)
Identification of post-transplant anti-alpha 5 (IV) collagen alloantibodies in X-linked Alport syndrome. (1996) (8)
Changes in intracellular enzymes of collagen biosynthesis during matrix-induced cartilage and bone development. (1981) (8)
Glomerulus proteome analysis with two-dimensional gel electrophoresis and mass spectrometry (2007) (8)
A meta-analysis of expression signatures in glomerular disease. (2013) (8)
Recombinant Human Laminin-10 (α5β1γ1) (2002) (8)
Erythromegakaryocytic cells synthesize laminin-8 (alpha4beta1gamma1). (2000) (7)
Assay for radiolabeled type IV collagen in the presence of other proteins using a specific collagenase. (1980) (7)
Whole-Genome Sequencing of Finnish Type 1 Diabetic Siblings Discordant for Kidney Disease Reveals DNA Variants associated with Diabetic Nephropathy. (2020) (7)
Expression of Novel Podocyte-Associated Proteins sult1b1 and ankrd25 (2010) (7)
Association of crumbs homolog-2 with mTORC1 in developing podocyte (2018) (6)
Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier (2013) (6)
Structure of the Mouse 92‐kDa Type IV Collagenase Gene (1994) (6)
Knockdown of Tmem234 in zebrafish results in proteinuria. (2015) (6)
A high-resolution map of human RNA translation. (2022) (6)
A Remote Cis-Acting Variant at 3q Links Glomerular NCK1 to Diabetic Nephropathy (2013) (5)
Viral proteases activate the CARD8 inflammasome in the human cardiovascular system (2022) (5)
Biochemistry and genetic diseases of glomerular basement membrane. (1993) (5)
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival (The Journal of Clinical Investigation (2011) 121, 10, (3965-3980) DOI: 10.1172/JCI58552) (2012) (5)
Glomerular basement membrane collagen and activities of the intracellular enzymes of collagen biosynthesis in congenital nephrotic syndrome of the Finnish type. (1978) (5)
Distribution of Type IV Collagen α1, α2 and α5 Chains in Human Tissues (1996) (4)
Loss of Type IV Collagen a5 and a6 Chains in Human Invasive Prostate Carcinomas (2007) (4)
Type IV collagen in normal and diseased glomerular basement membrane. (1993) (4)
A Hpa I polymorphism in the human laminin B1 chain gene on 7q22. (1989) (4)
Laminin-5 promotes adhesion and migration of epithelial cells: identification of a migration-related element in the γ2 chain gene (LAMC2) with activity in transgenic mice1Sirpa Salo and Heli Haakana contributed equally to this study.1 (1999) (4)
Alport syndrome: a genetic study of 31 families (1992) (4)
Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression. (2017) (4)
Expression of type IV collagenases in invasive tumors (1992) (3)
Distinct roles of integrins α6 and α4 in fetal liver hematopoietic stem and progenitor cell homing (2008) (3)
Alport’s Disease and Thin Basement Membrane Nephropathy (2009) (3)
20 – Alport Syndrome and Other Inherited Basement Membrane Disorders (1993) (3)
Assignment of the human collagen alpha 1 (XIII) chain gene (COL13A1) to the q22 region of chromosome 10. (1989) (3)
The Structural Genes for a1 and a2 Chains of Human Type IV Collagen Are Divergently Encoded on Opposite DNA Strands and Have an Overlapping (1988) (3)
Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis (2021) (3)
Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression (2014) (3)
A HindIII polymorphism in the 3' end of the human alpha 1(IV) collagen gene (1987) (3)
In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors. (2020) (3)
Extensive structural differences between genes for the alpha 1 and alpha 2 chains of type IV collagen despite conservation of coding sequences. (1987) (3)
Pattern of Basement Membrane Degradation by Metastatic Tumor Cell Enzymes (1986) (3)
COL4A5 splice site mutation and alpha 5(IV) collagen mRNA in Alport syndrome. (1993) (3)
A novel scavenger receptor 5-based antibiotic-independent selection method for generation of stable recombinant protein-producing mammalian cell lines especially suitable for proteins affecting cell adhesion. (2012) (3)
Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin (2015) (3)
Novel Retina Specific Laminin Isoforms Recapitulate Retinal Interphotoreceptor Matrix to Generate Human Embryonic Stem Cell-derived Photoreceptors (2018) (2)
Cloning of Alport syndrome gene. (1991) (2)
Laminin-5 γ 2 chain as an invasivity marker for uni- and multifocal lesions in the lower anogenital tract (2001) (2)
Glomerular Filtration Barrier: From Molecular Biology to Regulation Mechanisms (2014) (2)
A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane (2021) (2)
Structure of the human 70 K type IV collagenase gene and assignment of the gene to the q21 region of chromosome 16. (1992) (2)
Impaired endochondral ossification and angiogenesis in mice deficient in MT1-MMP (2000) (2)
[Waterhouse-Friderichsen syndrome]. (1959) (2)
Diseases of the Glomerular Filtration Barrier: Alport Syndrome and Congenital Nephrosis (NPHS1) (2003) (2)
Genes for the Human Laminin B1 and B2 Chains (1990) (2)
Expression and Subcellular Distribution of Novel Glomerulus-Associated Proteins Dendrin , Ehd 3 , Sh 2 d 4 a , Plekhh 2 , and 2310066 E 14 (2007) (2)
Closed‐circuit organ perfusion technique for gene transfer into the lungs. An experimental trial on farm pigs (2001) (2)
Evaluating Capture Sequence Performance for Single-Cell CRISPR Activation Experiments. (2021) (1)
Distribution of type IV collagen alpha 1, alpha 2 and alpha 5 chains in human tissues. (1996) (1)
Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region. (1987) (1)
Biologically Relevant Laminins (2013) (1)
Complex genetics of Alport and Goodpasture syndromes (2021) (1)
Perlecan compartmentalizes collagen X in the mammalian growth plate (2004) (1)
Mapping of the locus for congenital nephrotic syndrome of the Finnish type (CNF) on chromosome 19 (1994) (1)
Detection of Novel LAMC 2 Mutations in Herlitz Junctional Epidermolysis Bullosa (2007) (1)
[Structure and metabolism of basal membrane]. (1980) (1)
A Pst I polymorphism in the human laminin B2 chain gene on 1q25-q31. (1989) (1)
Subject Index Vol. 29, 2009 (2009) (0)
GELATINASE A (FULL-LENGTH) (1999) (0)
Contents Vol. 29, 2009 (2009) (0)
New genetic loci associated with increased urinary albumin excretion rate in subjects with type 1 diabetes (2014) (0)
MP086PODOCYTES CONTRIBUTE TO CARNITINE HOMEOSTASIS VIA EXPRESSING A CARNITINE EFFLUX TRANSPORTER SLC16A9 (2017) (0)
Laminins regulate vascular lumen diameter (2007) (0)
protects neutrophils from apoptosis neutrophils, promotes neutrophil migration and extravasation, and (2013) (0)
Contents Vol. 9, 2001 (2001) (0)
Spectrum of COL4A5 mutations in Finnish Alport syndrome patients Communicated by: Mark H. Paalman Online Citation: Human Mutation, Mutation in Brief #331 (2000) Online http://journals.wiley.com/1059-7794/pdf/mutation/331.pdf (2000) (0)
New genetic loci identified in a genome-wide meta-analysis of diabetic nephropathy: Oral Presentation (2011) (0)
Th-W61:4 Reduced atherosclerosis in Apo E-/- mice with heparan sulfate-deficient perlecan (2006) (0)
Identification and characterization of kidney glomerulus-associated genes and proteins (2012) (0)
Human Metabolomic Systems Biology Human Metabolomic Systems Biology (2008) (0)
TRANSCRIPTIONAL PROFILING OF GLOMERULI IN PDGF-B RETENTION MOTIF DEFICIENT MICE—IDENTIFICATION OF NOVEL MESANGIAL CELL SPECIFIC GENES IMPLICATED IN GLOMERULOSCLEROSIS (2004) (0)
Macrophage scavenger receptor MARCO contributes to the host response against bacterial infections (1997) (0)
Distinct Roles of Integrins α6 and α4 in Fetal Liver Hematopoietic Stem and Progenitor Cell Homing. (2006) (0)
Running title: Laminin in neutrophil migration and extravasation (2013) (0)
rapid communication CD 2 AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere (2000) (0)
Pluripotent Stem Cell-Derived Cardiovascular Progenitors Regenerate and Improve Function of Infarcted Pig Hearts (2022) (0)
Characterization of the promoter region for the human laminin γ2 chain gene (1994) (0)
Three-dimensional Structure of Human Tissue Inhibitor of Metalloproteinases-2 at 2 . 1 AÊ Resolution (1998) (0)
Does the Fenestrated Endothelium Contribute to the Macromolecular Barrier ? (0)
Cover Picture: Eur. J. Immunol. 5/10 (2010) (0)
PRESIDENTIAL ADDRESS (1973) (0)
Expression, purification and characterization of recombinant fragments of human perlecan synthesized in baculovirus-infected insect cells (1996) (0)
proMMP-2/TIMP-2 complex (2002) (0)
FUNCTIONAL GENOMIC ANALYSIS OF KIDNEY GLOMERULUS—TOWARD IDENTIFICATION OF NOVEL GLOMERULUS SPECIFIC GENES (2004) (0)
DELETIONS OF COLLAGEN TYPE 4 ALPHA 5 GENE IN 4 FAMILIES WITH ALPORT'S SYNDROME (1992) (0)
Subject Index Vol. 9, 2001 (2001) (0)
[Hereditary renal diseases and their genetic diagnosis]. (1995) (0)
Photoreceptor laminin drives differentiation of human pluripotent stem cells to photoreceptor progenitors that partially restore retina function. (2023) (0)
Nephrology Dialysis Transplantation Identification of post-transplant anti-« 5 ( IY ) collagen alloantibodies in X-linked Alport syndrome (2005) (0)
Catalytic domain of proMMP-2 E404Q mutant (2002) (0)
of human perlecan domains (1996) (0)
Inherited Disorders of the Glomerulus (2012) (0)
Recombinant non collagenous (NC1) type IV collagen subunits as a tool to characterize the immune response in anti-GBM nephritis (1995) (0)
From Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, Sweden CHARACTERIZATION OF NOVEL GLOMERULAR PROTEINS: ROLE IN PHYSIOLOGY AND DISEASE (2014) (0)
Disease of the Month Thin Basement Membrane Nephropathy (2006) (0)
Title Page / Contents / Preface (1996) (0)
Chemically defined and xenogeneic-free culture method for human epidermal keratinocytes on laminin-based matrices (2020) (0)
)1 a Migrate on Laminin-8 ( Monocytic Cells Synthesize, Adhere to, and (2000) (0)
Characterization of anti-GBM antibody reactivity subsequent to renal transplantation in two Alport Syndrome patients (1993) (0)
Best Practice & Research Clinical Obstetrics and Gynaecology (2011) (0)
Nephrin-role in the renal molecular sieve and involvement in nephrotic syndrome (2000) (0)
PLURIPOTENT STEM CELL-DERIVED CARDIOVASCULAR PROGENITORS DIFFFERENTIATED ON LAMININ 221 REGENERATE AND IMPROVE FUNCTION OF INFARCTED SWINE HEARTS (2021) (0)
Literature abstracts (2005) (0)
Clearance of Bacteria In Vivo Macrophage Scavenger Receptor MARCO in Regulation and Functional Involvement of (1998) (0)
Erratum: Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice (2012) (0)
Samuel A. Latt, 1938–1988 (1988) (0)
Short title: Role of α6-integrin in stem and progenitor cell homing (2006) (0)
Contents, Vol. 22, 1978 (1973) (0)
LN-521 enables derivation, clonal culture and easy single-cell passage of human pluripotent stem cells without artificial inhibitors (2014) (0)
Type IV collagen degrading collagenase: Molecular properties and inhibitory antibodies to the enzyme (1987) (0)
Human Alveolar Macrophages Unopsonized Particles and Bacteria on MARCO Is the Major Binding Receptor for (0)
Impaired Microvessel Maturation 4 Chain Leads to α Deletion of the Laminin (2014) (0)
Distinct roles of integrins (cid:1) 6 and (cid:1) 4 in homing of fetal liver hematopoietic stem and progenitor cells (2007) (0)
Altered NPYand AgRP in membrane type-1 matrix metalloproteinase-de¢cient mice (2004) (0)
NephrologyDialysis Transplantation Sera from patients with anti-GBM nephritis including Goodpasture syndrome show heterogenous reactivity to recombinant NCI domain of type IV collagen a chains (2005) (0)
Deletion of the Laminin (cid:2) 4 Chain Leads to Impaired Microvessel Maturation (2002) (0)
Basic Research Perlecan Heparan Sulfate Proteoglycan Is a Critical Determinant of Angiogenesis in Response to Mouse Hind-Limb Ischemia (2014) (0)
Monoclonal Antibodies to Collagen Hydroxylases and Their Use for the Localization of the Genes for These Enzymes on Human Chromosomes (1985) (0)
Anti-GBM antibodies from patients with Goodpasture Syndrome react with the NC1 domain of recombinant alpha3 (IV) and alpha4 (IV) collagen chains (1993) (0)
OF A NEW RENAL PATHOLOGY CODING LIST FOR THE FLEMISH RENAL BIOPSY (FCGG) REGISTRY (2017) (0)
In vivo generation of post-infarct mouse cardiac muscle by cardiomyocyte progenitors produced with a reproducible laminin-promoted human stem cell differentiation system (2018) (0)
Limit Pulmonary Dendritic Cell Migration Scavenger Receptors SR-AI/II and MARCO (2007) (0)
[Esophageal abnormalities. Remarks on detection and treatment before and after repair]. (1963) (0)
Immunological methods for detecting metastatic-zellaktivitaet (1984) (0)
Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture (2018) (0)
Nhe I and Hinc II polymorphisms in the human laminin B1 chain gene on 7q22. (1989) (0)
Expression and functional characterization of human perlecan domains I and II synthesized by baculovirus-infected insect cells (1996) (0)
S.04.08 Hypothalamic histochemistry in different genetic models of anorexia (2004) (0)
A Mesenchymal Cell Niche in Skin for Acute Myeloid Leukemia (2022) (0)
Crystal structure analysis of the monomeric SRCR domain of mouse MARCO (2007) (0)
Mutation in the a5(IV) Collagen Chain in Juvenile-Onset Alport Syndrome without Hearing Loss (2006) (0)
P.2.04 Hypothalamic histochemistry in different genetic models of anorexia (2004) (0)
bone marrow progenitor cells Laminin isoform-specific promotion of adhesion and migration of human (2013) (0)
Crystal structure analysis of the dimeric form of the SRCR domain of mouse MARCO (2007) (0)
A novel podocyte gene, R3h domain containing-like inhibits non-canonical TGF-beta signalling (2014) (0)
A systematic approach to the development of a safe live attenuated Zika vaccine (2018) (0)

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