Kai Wucherpfennig
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German-American biologist
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Immunology
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Biology
Why Is Kai Wucherpfennig Influential?
(Suggest an Edit or Addition)According to Wikipedia, Kai Wucherpfennig is a German-American biologist currently at the Dana–Farber Cancer Institute and an Elected Fellow of the American Association for the Advancement of Science.
Kai Wucherpfennig's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response (2018) (1823)
- An immunogenic personal neoantigen vaccine for patients with melanoma (2017) (1820)
- Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein (1995) (1567)
- Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007) (860)
- Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial (2018) (754)
- A functional and structural basis for TCR cross-reactivity in multiple sclerosis (2002) (548)
- A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing (2018) (535)
- Radiotherapy induces responses of lung cancer to CTLA-4 blockade (2018) (497)
- Deconstructing the Peptide-MHC Specificity of T Cell Recognition (2014) (431)
- The Organizing Principle in the Formation of the T Cell Receptor-CD3 Complex (2002) (419)
- MHC-II neoantigens shape tumor immunity and response to immunotherapy (2019) (413)
- Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. (2011) (410)
- Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. (1990) (407)
- Mechanisms for the induction of autoimmunity by infectious agents. (2001) (407)
- Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes (2001) (380)
- Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif (2008) (374)
- Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq (2018) (368)
- A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor (1999) (346)
- Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones (1994) (345)
- Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein (2007) (321)
- Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. (2003) (318)
- Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein (1998) (289)
- T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity (2017) (278)
- Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor (2005) (265)
- Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 (2012) (260)
- Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. (1994) (258)
- Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity (2018) (254)
- A facile approach to enhance antigen response for personalized cancer vaccination (2018) (253)
- Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. (2007) (246)
- Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. (1995) (230)
- B cell homeostasis and follicle confines are governed by fibroblastic reticular cells (2014) (225)
- Polarized release of TCR-enriched microvesicles at the T cell immunological synapse (2014) (224)
- Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases (1995) (214)
- Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. (2004) (207)
- Polyspecificity of T cell and B cell receptor recognition. (2007) (205)
- Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex (2000) (197)
- The T cell receptor: critical role of the membrane environment in receptor assembly and function. (2005) (196)
- Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes. (1997) (193)
- The Structure of the ζζ Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor (2006) (192)
- Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application. (2002) (192)
- In vivo discovery of immunotherapy targets in the tumour microenvironment (2014) (184)
- The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. (2005) (183)
- Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein1 (2005) (174)
- The structural basis for intramembrane assembly of an activating immunoreceptor complex (2010) (171)
- Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. (2010) (169)
- Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma (2021) (168)
- Immunotherapy advances for glioblastoma. (2014) (158)
- Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy (2020) (156)
- Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. (2011) (151)
- Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection (2012) (150)
- Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. (2020) (147)
- Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. (2021) (146)
- Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major. (2000) (144)
- Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple Sclerosis1 (2009) (140)
- Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis (2021) (132)
- Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma: A Phase 2 Open-Label Randomized Clinical Trial. (2020) (130)
- T-cell recognition of myelin basic protein. (1991) (128)
- Clinical and MRI phenotype of children with MOG antibodies (2016) (128)
- Analysis of the relationship between viral infection and autoimmune disease. (2001) (127)
- Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. (1998) (119)
- Structural basis of molecular mimicry. (2001) (119)
- Ex vivo characterization and isolation of rare memory B cells with antigen tetramers. (2011) (118)
- Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. (2014) (118)
- Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. (2020) (110)
- Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis1 (2005) (109)
- FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors (2018) (109)
- Stoichiometry of the T‐cell receptor–CD3 complex and key intermediates assembled in the endoplasmic reticulum (2004) (108)
- T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes (2019) (107)
- T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. (1992) (103)
- Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. (2004) (103)
- Expression of Recombinant HLA-DR2 Molecules (1996) (100)
- Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions (2003) (100)
- Common themes in the assembly and architecture of activating immune receptors (2007) (99)
- Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. (2012) (96)
- Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures. (1999) (95)
- Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression (2008) (94)
- Prevention of type 1 diabetes by gene therapy. (2004) (92)
- pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH (1999) (92)
- Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain (2012) (92)
- Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. (2009) (91)
- B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. (2008) (91)
- A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC (2011) (91)
- Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments (2019) (91)
- Suppression of Autoimmune Diabetes by Soluble Galectin-11 (2009) (89)
- Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). (2007) (88)
- Landscape of B cell immunity and related immune evasion in human cancers (2018) (88)
- MicroRNA Expression Profiling Identifies Activated B Cell Status in Chronic Lymphocytic Leukemia Cells (2011) (87)
- The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. (2006) (86)
- Self-reactive human CD4 T cell clones form unusual immunological synapses (2012) (86)
- Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. (2005) (85)
- The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. (2003) (83)
- Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals. (2001) (82)
- Functional three-domain single-chain T-cell receptors. (1994) (81)
- T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. (2011) (80)
- Structural Factors Contributing to DM Susceptibility of MHC Class II/Peptide Complexes1 (2002) (79)
- Detection of Autoreactive Myelin Proteolipid Protein 139–151-Specific T Cells by Using MHC II (IAs) Tetramers1 (2003) (78)
- T cell receptor crossreactivity as a general property of T cell recognition. (2004) (78)
- In Vivo Survival of Viral Antigen–specific T Cells that Induce Experimental Autoimmune Encephalomyelitis (1998) (78)
- Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition. (1999) (76)
- Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. (2004) (75)
- Kinetics of T-cell Receptor Binding by Bivalent HLA-DR·Peptide Complexes That Activate Antigen-specific Human T-cells* (2000) (74)
- The Assembly of Diverse Immune Receptors Is Focused on a Polar Membrane-Embedded Interaction Site (2006) (72)
- Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85VVHFFKNIVTP96 in chronic progressive multiple sclerosis (1997) (70)
- Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma (2020) (68)
- Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes (2000) (67)
- Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. (2010) (67)
- Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. (2020) (67)
- Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion (2021) (66)
- Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. (1992) (65)
- Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. (2014) (65)
- Multicomponent Injectable Hydrogels for Antigen‐Specific Tolerogenic Immune Modulation (2017) (63)
- An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma (2013) (62)
- Common T‐cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis (1991) (62)
- Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules. (1999) (62)
- The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection (2017) (62)
- The Tumor Microenvironment Shapes Lineage, Transcriptional, and Functional Diversity of Infiltrating Myeloid Cells (2014) (62)
- Anergy Induction by Dimeric TCR Ligands1 (2001) (60)
- Structural basis of T‐cell specificity and activation by the bacterial superantigen TSST‐1 (2007) (60)
- Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors (2016) (58)
- HLA-DM Captures Partially Empty HLA-DR Molecules for Catalyzed Peptide Removal (2010) (57)
- Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. (2018) (57)
- Faculty Opinions recommendation of Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. (2011) (55)
- Discovery of specialized NK cell populations infiltrating human melanoma metastases. (2019) (55)
- Empty Class II Major Histocompatibility Complex Created by Peptide Photolysis Establishes the Role of DM in Peptide Association* (2007) (55)
- Activation of autoreactive T cells by peptides from human pathogens (1997) (55)
- Metabolic labeling and targeted modulation of dendritic cells (2020) (54)
- Small Molecules That Enhance the Catalytic Efficiency of HLA-DM1 (2006) (54)
- A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ81 (2004) (54)
- Integrin αvβ6-TGFβ-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer. (2020) (54)
- Ex Vivo Analysis of Thymic CD4 T Cells in Nonobese Diabetic Mice with Tetramers Generated from I-Ag7/Class II-Associated Invariant Chain Peptide Precursors 1 (2003) (53)
- Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. (1995) (53)
- Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. (2012) (53)
- The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. (2012) (52)
- Mechanisms of peptide repertoire selection by HLA-DM. (2013) (52)
- Understanding and treating the inflammatory adverse events of cancer immunotherapy (2021) (51)
- Autoimmunity in the central nervous system: mechanisms of antigen presentation and recognition. (1994) (51)
- Variable Patterns of Programmed Death-1 Expression on Fully Functional Memory T Cells after Spontaneous Resolution of Hepatitis C Virus Infection (2008) (48)
- Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. (2001) (47)
- Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. (2005) (45)
- Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity. (2003) (45)
- Type 1 diabetes (2001) (45)
- Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease (2017) (44)
- Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein. (1998) (43)
- Epithelial endoplasmic reticulum stress orchestrates a protective IgA response (2019) (42)
- Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells (1993) (40)
- Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling (2016) (40)
- Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells (2020) (40)
- Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (2021) (40)
- A Membrane-proximal Tetracysteine Motif Contributes to Assembly of CD3δϵ and CD3γϵ Dimers with the T Cell Receptor* (2006) (39)
- In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange1 (2009) (39)
- Signaling by the Epstein–Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses (2018) (39)
- Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. (2020) (38)
- Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy (2022) (38)
- Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules (2004) (38)
- Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma (2021) (37)
- Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop (2013) (36)
- Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. (1998) (34)
- Response Multilayered Control of T Cell Receptor Phosphorylation (2010) (34)
- Immunotherapy for glioblastoma: on the sidelines or in the game? (2017) (34)
- Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses (2018) (34)
- A Review of T‐Cell Receptors in Multiple Sclerosis: Clonal Expansion and Persistence of Human T‐Cells Specific for an Immunodominant Myelin Basic Protein Peptide a (1995) (33)
- Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure (2001) (33)
- Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation (2004) (33)
- Inhibition of CDK4/6 promotes CD8 T-cell memory formation. (2021) (32)
- Systematic Investigation of Cytokine Signaling Activity at the Tissue and Single-Cell Level (2021) (32)
- Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer (2020) (29)
- Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function (2014) (28)
- Mechanism of EBV inducing anti-tumour immunity and its therapeutic use (2020) (28)
- Infectious triggers for inflammatory neurological diseases (2002) (24)
- A vaccine targeting resistant tumours by dual T cell plus NK cell attack (2022) (23)
- The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination. (2005) (23)
- Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells (2020) (23)
- MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets (2021) (22)
- Expansion and Contraction of HIV-Specific CD4 T Cells with Short Bursts of Viremia, but Physical Loss of the Majority of These Cells with Sustained Viral Replication1 (2005) (22)
- Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function (2022) (20)
- Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma (2018) (20)
- MHC‐Linked Susceptibility to Type 1 Diabetes (2003) (20)
- Immunomodulation for glioblastoma (2017) (20)
- Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity (2018) (19)
- Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis (2022) (19)
- CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor cells and T cells. (2021) (19)
- Presentation of a Self-peptide in Two Distinct Conformations by a Disease-associated HLA-B27 Subtype (2004) (18)
- Faculty Opinions recommendation of Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. (2005) (17)
- Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity. (2019) (17)
- Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. (2011) (17)
- MHC-II neoantigens shape tumour immunity and response to immunotherapy (2019) (17)
- The Solvent-Inaccessible Cys67 Residue of HLA-B27 Contributes to T Cell Recognition of HLA-B27/Peptide Complexes1 (2004) (16)
- MHC-linked susceptibility to type 1 diabetes: a structural perspective. (2003) (16)
- Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors (2020) (15)
- Expression of the B7.1 Costimulatory Molecule on Pancreatic β Cells Abrogates the Requirement for CD4 T Cells in the Development of Type 1 Diabetes1 (2004) (15)
- Genetic screens to study the immune system in cancer. (2016) (14)
- Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. (2007) (14)
- cIAP1/2 antagonism eliminates MHC class I–negative tumors through T cell–dependent reprogramming of mononuclear phagocytes (2021) (12)
- Complexed with a Peptide from Human Myelin Basic Protein (1998) (11)
- The First Structures of T Cell Receptors Bound to Peptide–MHC (2010) (10)
- Visualization and quantification of NK cell-mediated cytotoxicity over extended time periods by image cytometry. (2019) (9)
- Cutting Edge: CD4CD25 Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis 1 (2005) (9)
- Immunosuppressive Myeloid Cells Induce Nitric Oxide–Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells (2021) (9)
- Frontline: Self‐peptides that bind with low affinity to the diabetes‐associated I‐Ag7 molecule readily induce T cell tolerance in non‐obese diabetic mice (2004) (7)
- MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia. (2021) (6)
- Effect of dexamethasone in glioblastoma (GBM) patients on systemic and intratumoral T-cell responses induced by personalized neoantigen-targeting vaccine. (2018) (6)
- Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. (2004) (6)
- The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple Sclerosis (1991) (6)
- Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasion (2020) (6)
- Mechanical checkpoint regulates monocyte differentiation in fibrotic niches (2022) (6)
- Cracking the code of human T-cell immunity (2013) (6)
- mRNA duplexes by human Ago proteins − Alternative RISC assembly : Binding and repression of microRNA Material Supplemental (2012) (5)
- The Structure of the zz Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor (5)
- Positively selecting peptides: their job does not end in the thymus (2009) (5)
- Human Fetal Liver ' y / ~ T Cells Predominantly Use Unusual Rearrangements of the T Cell Receptor and " y Loci Expressed on Both CD 4 + CD 8-and C D 4C D 8-T Cells (2003) (5)
- Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response (2018) (5)
- Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET. (2017) (4)
- Rapid T Cell Response to Vaccination Can Occur without Antibody Response in Children Post HSCT. (2004) (4)
- Immunologic mechanisms in chronic demyelinating diseases of the central and peripheral nervous system. (1990) (4)
- MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma (2022) (4)
- Target discovery for T cell therapy: next steps to advance Immunotherapies (2015) (4)
- Inhibition of MAN2A1 enhances tumor response to anti-PD-L1. (2020) (3)
- Engineered myelin basic protein (MBP)-specific human T regulatory cells ameliorate myelin oligodendrocyte glycoprotein (MOG) peptide-induced Experimental Autoimmune Encephalomyelitis in vivo (2017) (3)
- Integrin avb6–TGFb–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer (2020) (3)
- Abstract 5631: Personal neoantigen-targeting vaccination generates neoepitope-specific T cell responses in tumors of patients with glioblastoma (2018) (3)
- Dual Chimeric Antigen Receptor Approach Combining Novel Tumor Targeting Strategies Circumvents Antigen Escape in Multiple Myeloma (2021) (3)
- Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers (2019) (3)
- Designing Cancer Immunotherapies That Engage T Cells and NK Cells. (2022) (3)
- Autoimmune diseases have been the focus of intense research efforts. (2011) (3)
- Cytokine conjugation to enhance T cell therapy. (2022) (3)
- Myelin-specific Regulatory T Cells Accumulate in the Central Nervous System, but Fail to Suppress Pathogenic Effector T Cells at the Peak of Autoimmune Inflammation (2007) (3)
- The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity (2022) (2)
- A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma (2022) (2)
- Abstract 1591: FT536: Preclinical development of a novel off-the-shelf CAR-MICA/B NK cell immunotherapy combined with radiation and antibody treatments as a first-of-kind pan-cancer targeting strategy (2021) (2)
- Breast cancer prevention by short-term inhibition of TGFβ signaling (2022) (2)
- RHEUMATIC DISEASES Immunological mechanisms and prospects for new therapies (1999) (2)
- Discovering cancer immunotherapy targets in vivo (2014) (2)
- SclerosisMyelin Surface Antigen in Pediatric Multiple Age-Dependent B Cell Autoimmunity to a (2009) (2)
- Landscape of B cell immunity and related immune evasion in human cancers (2019) (1)
- Faculty Opinions recommendation of Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. (2005) (1)
- 2 - Implications of T Cell Receptor Crossreactivity for the Pathogenesis of Autoimmune Diseases (2004) (1)
- Multilayered Control of T Cell Receptor Phosphorylation Response (2010) (1)
- First-in-human CAN-3110 (ICP-34.5 expressing HSV-1 oncolytic virus) in patients with recurrent high-grade glioma. (2021) (1)
- Crystal structure of a human insulin peptide-HLA-DQ8 complex (2001) (1)
- Immune-Tumor Interactions in Resistance to Cancer Immunotherapy (2019) (1)
- HLA and Autoimmunity (2006) (1)
- Crystal structure of HLA-DM (2006) (1)
- The structure and function of antigen receptors (2007) (1)
- Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P VVHFFKNIVTP in chronic progressive (1997) (1)
- Development of a Novel MICA/B-Specific CAR As a Pan-Tumor Targeting Strategy for Off-the-Shelf, Cell-Based Cancer Immunotherapy (2020) (1)
- The role of MHC class II polymorphisms for DM-mediated peptide editing and autoimmunity (2017) (1)
- Corrigendum: S100-alarmin-induced innate immune programming protects newborn infants from sepsis (2017) (1)
- Analysis of αβ and γδ T cell receptors in multiple sclerosis plaques (1991) (1)
- Mechanical Checkpoint Regulates Monocyte Differentiation in Fibrotic Matrix (2021) (1)
- Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection (2017) (1)
- 117 FT536 Path to IND: Ubiquitous targeting of solid tumors with an off-the-shelf, first-of-kind MICA/B-specific CAR-iNK cellular immunotherapy (2021) (1)
- TAMI-12. CANCER-IMMUNE CELL INTERACTIONS DRIVE TRANSITIONS TO MESENCHYMAL-LIKE STATES IN GLIOBLASTOMA (2021) (0)
- Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer (2022) (0)
- Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance (2019) (0)
- Structure and Function of TCRαβ Receptors (2016) (0)
- Molecule HLA-DQ 8 Myocarditis Using the Human MHC A Spontaneous Model for Autoimmune (2004) (0)
- Rheumatic Diseases: The role of T cells in autoimmune disease (1999) (0)
- Local changes in lipid environment of T cell receptor microclusters regulate membrane binding by the CD3epsilon cytoplasmic domain (P1103) (2013) (0)
- Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers (2019) (0)
- EPEN-21. IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION IN PEDIATRIC EPENDYMOMA REVEALED BY SINGLE-CELL RNA-SEQ (2020) (0)
- Altered Synapse Formation by Self-reactive T Cells from MS Patients (2010) (0)
- Structure of Zeta-Zeta Transmembrane Dimer (2006) (0)
- Mechanism of EBV inducing anti-tumour immunity and its therapeutic use (2020) (0)
- Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses (2018) (0)
- T Cell Receptor Va-Vo Repertoire and Cytokine Gene Expression in Active Multiple Sclerosis Lesions (2003) (0)
- Structural basis of DAP12-associated intramembrane immunoreceptor assembly. (138.16) (2010) (0)
- Movie S7. Time-Lapse Imaging Shows the Interaction of WT DCs with Pdpn−/− FRCs Cultured in 3D Matrix (2012) (0)
- Role of Disorder in T-Cell Signaling (2012) (0)
- Crystal structure of an immune complex (2013) (0)
- EPCO-35. SINGLE-CELL RNA-SEQ OF PEDIATRIC EPENDYMOMA REVEALS PROGNOSTIC IMPACT OF IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION (2020) (0)
- Polarized release and retroviral subversion of TCR-enriched microvesicles at the T cell immunological synapse (P6155) (2013) (0)
- Abstract 2068: A highly selective dual Haspin-kinase and PIM-inhibitor overcomes RAF/MEK-inhibitor resistance in melanoma (2019) (0)
- OTME-8. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis (2021) (0)
- Movie S4. Time-Lapse Imaging Shows DCs Approaching Branched FRCs in 3D Matrix (2012) (0)
- Inhibition of MICA and MICB Shedding Enhances Cytokine-Induced Memory-like NK Cell-Mediated Activity Against Multiple Myeloma (2022) (0)
- Reply (1991) (0)
- OTME-7. Cancer - immune cell interactions drive transitions to mesenchymal-like state in glioblastoma (2021) (0)
- HLA-B 27 / Peptide Complexes HLA-B 27 Contributes to T Cell Recognition Residue of 67 The Solvent-Inaccessible (2004) (0)
- Abstract 5387: Novel targeted single-cell TCR sequencing method used for analysis of a T cell infiltrate from a glioblastoma patient (2018) (0)
- Advances in Brief Equivalent Induction of Telomerase-specific Cytotoxic T Lymphocytes from Tumor-bearing Patients and Healthy Individuals 1 (2001) (0)
- Structural Characterization of an Unusual Binding Mode of a Myelin-specific T Cell Receptor (2010) (0)
- Structural Basis of T-Cell Receptor Specificity and Cross-Reactivity: Implications for Pathogenesis of Human Autoimmune Diseases (2000) (0)
- F.14. Autoantibodies to Myelin Oligodendrocyte Glycoprotein in Pediatric MS (2008) (0)
- Susceptibility of MHC Class II / Peptide Structural Factors Contributing to DM (2002) (0)
- Invariant Chain Peptide Precursors /Class II-Associated g7 Generated from I-A Nonobese Diabetic Mice with Tetramers Ex Vivo Analysis of Thymic CD4 T Cells in (2003) (0)
- Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial (2018) (0)
- Movie S6. Time-Lapse Imaging Shows the Interaction of Clec1b−/− DCs with WT FRCs Cultured in 3D Matrix (2012) (0)
- HLA and Autoimmunity: Structural Basis of Immune Recognition (2006) (0)
- Abstract A176: Overcoming CD8 T-cell suppression in the tumor microenvironment (2019) (0)
- Abstract 4174: Augmenting NK cell based immunotherapy by targeting mitochondrial apoptosis (2022) (0)
- Helicobacter Pylori Infection and Immunity Edited by Yoshimasa Yamamoto, Herman Friedman, Paul S. Hoffman, Kluwer Academic/Plenum Publishers, New York, Price: $135.00 (2002) (0)
- Structure of the DAP12-NKG2C transmembrane heterotrimer (2010) (0)
- Crystal structure of HLA-DM bound to HLA-DR1 (2013) (0)
- Oplöselige monovalent and multivalent MHC Class II fusion proteins, and uses thereof (1997) (0)
- Crystallization of the complex of HLA-DR2 with immunodominant myelin basic protein peptide (1998) (0)
- Ablated intestinal stem cells recover predominantly by ASCL2-dependent dedifferentiation of their recent progeny (2020) (0)
- II Molecules Antigens Presented by Different MHC Class Cross-Reactive TCR Responses to Self (2004) (0)
- Efficient Activation of Self-reactive T Cells from MS Patients with Altered Synapse Formation (2010) (0)
- P-021: 7C6 is a novel monoclonal antibody that induces enhanced anti-myeloma activity of cytokine induced memory-like (CIML) NK cells by blocking MICA/B shedding and antibodydependent cell cytotoxicity (2022) (0)
- COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UNE INFECTION À ARÉNAVIRUS (2017) (0)
- Abstract A146: Systematic discovery of immune regulatory mechanisms in tumor cells (2019) (0)
- Engineered MBP antigen-specific human regulatory T cells: direct and bystander immunosuppressive function (THER7P.954) (2015) (0)
- Modulating MHC Class II Antigen Processing in Dendritic Cells Prevents Diabetes in NOD mice (78.25) (2009) (0)
- Development of Type 1 Diabetes Requirement for CD 4 T Cells in the Cells Abrogates the β Molecule on Pancreatic Expression of the B 7 . 1 (2004) (0)
- Myelin specific regulatory T cells expand from naturally occurring regulatory T cells and accumulate in the CNS during EAE (128.8) (2007) (0)
- T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity (2017) (0)
- X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase (2002) (0)
- vy 6 T-cell receptor repertoire in acute multiple sclerosis lesions (0)
- Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines. (2023) (0)
- Radiotherapy induces responses of lung cancer to CTLA-4 blockade (2018) (0)
- 114 Preclinical development of a novel iPSC-derived CAR-MICA/B NK cell immunotherapy to overcome solid tumor escape from NKG2D-mediated mechanisms of recognition and killing (2020) (0)
- Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer (2020) (0)
- HTLV-1 induced spontaneous T cell clonal proliferation is rapamycin sensitive (1991) (0)
- Movie S2. Confocal Time-Lapse Imaging of DC Motility in LN Slices from WT BM → Ub-GFP Mice (2012) (0)
- Correction: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells (2020) (0)
- Structure of the DAP12 transmembrane homodimer (2010) (0)
- Movie S5. Time-Lapse Imaging Shows the Migration of WT DCs along WT FRCs Cultured in 3D Matrix (2012) (0)
- Small molecule enhancers of peptide binding to MHC class II: Implications for DM function (130.40) (2010) (0)
- EncephalomyelitisSusceptibility to Experimental Autoimmune Cells Contribute to Gender Differences in Regulatory T + CD25+ Cutting Edge: CD4 (2005) (0)
- Isolation of human anti-MICA antibody from cancer patients responding to immunotherapies. (2012) (0)
- Sustained Viral Replication Physical Loss of the Majority of These Cells with T Cells with Short Bursts of Viremia , but Expansion and Contraction of HIV-Specific CD 4 (2005) (0)
- ATIM-32. PERSONALIZED NEOANTIGEN-TARGETING VACCINE GENERATES ROBUST SYSTEMIC AND INTRATUMORAL T CELL RESPONSES IN GLIOBLASTOMA (GBM) PATIENTS (2018) (0)
- A structural platform for B cell receptor signaling (2022) (0)
- 395 Detection of viral antigen and immune activation after intra-tumor injection of CAN-3110 (ICP-34.5 expressing HSV-1 oncolytic virus) in patients with recurrent high-grade glioma (2021) (0)
- A vaccine targeting resistant tumours by dual T cell plus NK cell attack (2022) (0)
- Development and Function Domain Is Required for Optimal T Cell Signaling ε Membrane Association of the CD 3 Vignali (2014) (0)
- antigen-presenting cells: potential for clinical application efficiently induced by means of CD40-activated B cells as Human primary and memory cytotoxic T lymphocyte responses are (2013) (0)
- Abstract A055: Systematic discovery of combinationimmunotherapy targets in vivo (2016) (0)
- Oligodendrocyte Glycoprotein System Tissue Recognize Myelin Antibodies from Inflamed Central Nervous (2005) (0)
- Fusion proteins of MHC class II, soluble, monovalent or polyvalent, and their uses. (1997) (0)
- TCR/HLA-DR2b/MBP-peptide complex (2005) (0)
- The First Structures of T Cell Receptors (2010) (0)
- Peptide Recognition That Determine the Degree of Degeneracy in Structural Features of Autoreactive TCR (1998) (0)
- Faculty Opinions recommendation of NKG2D blockade prevents autoimmune diabetes in NOD mice. (2004) (0)
- A Novel Combination of TGF-β Inhibitor and DC/AML Fusion Vaccine for Management of AML in an Immunocompetent Murine Model (2022) (0)
- Arthritis-Associated HLA-DR Molecules Sclerosis- and Rheumatoid Binding Motifs of Copolymer 1 to Multiple (1999) (0)
- Abstract SY45-04: Development of therapeutic strategies by resolving the tumor ecosystem (2019) (0)
- Correction (1912) (0)
- Mouse CD3epsilon Cytoplasmic Tail (2008) (0)
- Potential of antigen-specific adoptive immunotherapy using peptide/mhc tetramers and microbeads for highyield purification of cytotoxic t lymphocytes from peripheral blood (2000) (0)
- Abstract 4190: Combining dual CAR iPSC-derived immune cells with antibody for multi-antigen targeting to overcome clonal resistance in multiple myeloma (2022) (0)
- Abstract B132: Inhibition of Haspin kinase to promote cell-intrinsic and extrinsic anticancer therapy (2019) (0)
- Abstract 700: CellSig: A data-driven model of cytokine activity identifies therapeutic targets for severe COVID-19 and cancer immunotherapy-induced colitis (2021) (0)
- Su.32. Myelin-specific Regulatory T Cells Accumulatein the Central Nervous System, but Fail to Suppress Pathogenic Effector T Cells at the Peak of Autoimmune Inflammation [abstract only] (2007) (0)
- Crystal structure of an immune complex at pH 6.5 (2013) (0)
- Abstract 2325: Long term time-course monitoring of NK cell-mediated ADCC using the Celigo Image Cytometer (2019) (0)
- Crystal structure of a autoimmune TCR-MHC complex (2013) (0)
- Detection of autoantibodies with self-assembling radiolabeled antigen tetramers (2007) (0)
- Faculty Opinions recommendation of Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. (2005) (0)
- Polarized release of TCR‐enriched microvesicles at the center of the T cell immunological synapse (2013) (0)
- Peptide independent assembly of HLA-DR2 molecules from subunits expressed in E. coli (1994) (0)
- 204 Combining FT536, a pan-tumor targeting CAR NK cell therapy, with CD16 engagers provides a coordinated targeting strategy to overcome tumor heterogeneity (2022) (0)
- Abstract P2-14-18: A randomized phase II trial of carboplatin with or without nivolumab in metastatic triple-negative breast cancer (2022) (0)
- Gene Activation During Experimental Allergic Encephalomyelitis (1988) (0)
- Structure of Autoimmune TCR Hy.1B11 in complex with HLA-DQ1 and MBP 85-99 (2010) (0)
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