Kai Wucherpfennig

Kai Wucherpfennig's AcademicInfluence.com Rankings

Kai Wucherpfennig

Biology

#8063

World Rank

#11079

Historical Rank

Immunology

#461

World Rank

#478

Historical Rank

Molecular Biology

#1036

World Rank

#1060

Historical Rank

biology Degrees

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Biology

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According to Wikipedia, Kai Wucherpfennig is a German-American biologist currently at the Dana–Farber Cancer Institute and an Elected Fellow of the American Association for the Advancement of Science.

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Kai Wucherpfennig's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response (2018) (1823)
An immunogenic personal neoantigen vaccine for patients with melanoma (2017) (1820)
Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein (1995) (1567)
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007) (860)
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial (2018) (754)
A functional and structural basis for TCR cross-reactivity in multiple sclerosis (2002) (548)
A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing (2018) (535)
Radiotherapy induces responses of lung cancer to CTLA-4 blockade (2018) (497)
Deconstructing the Peptide-MHC Specificity of T Cell Recognition (2014) (431)
The Organizing Principle in the Formation of the T Cell Receptor-CD3 Complex (2002) (419)
MHC-II neoantigens shape tumor immunity and response to immunotherapy (2019) (413)
Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. (2011) (410)
Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. (1990) (407)
Mechanisms for the induction of autoimmunity by infectious agents. (2001) (407)
Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes (2001) (380)
Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif (2008) (374)
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq (2018) (368)
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor (1999) (346)
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones (1994) (345)
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein (2007) (321)
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. (2003) (318)
Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein (1998) (289)
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity (2017) (278)
Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor (2005) (265)
Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 (2012) (260)
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. (1994) (258)
Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity (2018) (254)
A facile approach to enhance antigen response for personalized cancer vaccination (2018) (253)
Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. (2007) (246)
Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. (1995) (230)
B cell homeostasis and follicle confines are governed by fibroblastic reticular cells (2014) (225)
Polarized release of TCR-enriched microvesicles at the T cell immunological synapse (2014) (224)
Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases (1995) (214)
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. (2004) (207)
Polyspecificity of T cell and B cell receptor recognition. (2007) (205)
Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex (2000) (197)
The T cell receptor: critical role of the membrane environment in receptor assembly and function. (2005) (196)
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes. (1997) (193)
The Structure of the ζζ Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor (2006) (192)
Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application. (2002) (192)
In vivo discovery of immunotherapy targets in the tumour microenvironment (2014) (184)
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. (2005) (183)
Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein1 (2005) (174)
The structural basis for intramembrane assembly of an activating immunoreceptor complex (2010) (171)
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. (2010) (169)
Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma (2021) (168)
Immunotherapy advances for glioblastoma. (2014) (158)
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy (2020) (156)
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. (2011) (151)
Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection (2012) (150)
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. (2020) (147)
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. (2021) (146)
Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major. (2000) (144)
Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple Sclerosis1 (2009) (140)
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis (2021) (132)
Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma: A Phase 2 Open-Label Randomized Clinical Trial. (2020) (130)
T-cell recognition of myelin basic protein. (1991) (128)
Clinical and MRI phenotype of children with MOG antibodies (2016) (128)
Analysis of the relationship between viral infection and autoimmune disease. (2001) (127)
Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. (1998) (119)
Structural basis of molecular mimicry. (2001) (119)
Ex vivo characterization and isolation of rare memory B cells with antigen tetramers. (2011) (118)
Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. (2014) (118)
Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. (2020) (110)
Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis1 (2005) (109)
FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors (2018) (109)
Stoichiometry of the T‐cell receptor–CD3 complex and key intermediates assembled in the endoplasmic reticulum (2004) (108)
T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes (2019) (107)
T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. (1992) (103)
Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. (2004) (103)
Expression of Recombinant HLA-DR2 Molecules (1996) (100)
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions (2003) (100)
Common themes in the assembly and architecture of activating immune receptors (2007) (99)
Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. (2012) (96)
Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures. (1999) (95)
Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression (2008) (94)
Prevention of type 1 diabetes by gene therapy. (2004) (92)
pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH (1999) (92)
Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain (2012) (92)
Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. (2009) (91)
B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. (2008) (91)
A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC (2011) (91)
Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments (2019) (91)
Suppression of Autoimmune Diabetes by Soluble Galectin-11 (2009) (89)
Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). (2007) (88)
Landscape of B cell immunity and related immune evasion in human cancers (2018) (88)
MicroRNA Expression Profiling Identifies Activated B Cell Status in Chronic Lymphocytic Leukemia Cells (2011) (87)
The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. (2006) (86)
Self-reactive human CD4 T cell clones form unusual immunological synapses (2012) (86)
Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. (2005) (85)
The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. (2003) (83)
Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals. (2001) (82)
Functional three-domain single-chain T-cell receptors. (1994) (81)
T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. (2011) (80)
Structural Factors Contributing to DM Susceptibility of MHC Class II/Peptide Complexes1 (2002) (79)
Detection of Autoreactive Myelin Proteolipid Protein 139–151-Specific T Cells by Using MHC II (IAs) Tetramers1 (2003) (78)
T cell receptor crossreactivity as a general property of T cell recognition. (2004) (78)
In Vivo Survival of Viral Antigen–specific T Cells that Induce Experimental Autoimmune Encephalomyelitis (1998) (78)
Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition. (1999) (76)
Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. (2004) (75)
Kinetics of T-cell Receptor Binding by Bivalent HLA-DR·Peptide Complexes That Activate Antigen-specific Human T-cells* (2000) (74)
The Assembly of Diverse Immune Receptors Is Focused on a Polar Membrane-Embedded Interaction Site (2006) (72)
Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85VVHFFKNIVTP96 in chronic progressive multiple sclerosis (1997) (70)
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma (2020) (68)
Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes (2000) (67)
Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. (2010) (67)
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. (2020) (67)
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion (2021) (66)
Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. (1992) (65)
Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. (2014) (65)
Multicomponent Injectable Hydrogels for Antigen‐Specific Tolerogenic Immune Modulation (2017) (63)
An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma (2013) (62)
Common T‐cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis (1991) (62)
Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules. (1999) (62)
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection (2017) (62)
The Tumor Microenvironment Shapes Lineage, Transcriptional, and Functional Diversity of Infiltrating Myeloid Cells (2014) (62)
Anergy Induction by Dimeric TCR Ligands1 (2001) (60)
Structural basis of T‐cell specificity and activation by the bacterial superantigen TSST‐1 (2007) (60)
Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors (2016) (58)
HLA-DM Captures Partially Empty HLA-DR Molecules for Catalyzed Peptide Removal (2010) (57)
Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. (2018) (57)
Faculty Opinions recommendation of Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. (2011) (55)
Discovery of specialized NK cell populations infiltrating human melanoma metastases. (2019) (55)
Empty Class II Major Histocompatibility Complex Created by Peptide Photolysis Establishes the Role of DM in Peptide Association* (2007) (55)
Activation of autoreactive T cells by peptides from human pathogens (1997) (55)
Metabolic labeling and targeted modulation of dendritic cells (2020) (54)
Small Molecules That Enhance the Catalytic Efficiency of HLA-DM1 (2006) (54)
A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ81 (2004) (54)
Integrin αvβ6-TGFβ-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer. (2020) (54)
Ex Vivo Analysis of Thymic CD4 T Cells in Nonobese Diabetic Mice with Tetramers Generated from I-Ag7/Class II-Associated Invariant Chain Peptide Precursors 1 (2003) (53)
Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. (1995) (53)
Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. (2012) (53)
The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. (2012) (52)
Mechanisms of peptide repertoire selection by HLA-DM. (2013) (52)
Understanding and treating the inflammatory adverse events of cancer immunotherapy (2021) (51)
Autoimmunity in the central nervous system: mechanisms of antigen presentation and recognition. (1994) (51)
Variable Patterns of Programmed Death-1 Expression on Fully Functional Memory T Cells after Spontaneous Resolution of Hepatitis C Virus Infection (2008) (48)
Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. (2001) (47)
Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. (2005) (45)
Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity. (2003) (45)
Type 1 diabetes (2001) (45)
Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease (2017) (44)
Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein. (1998) (43)
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response (2019) (42)
Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells (1993) (40)
Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling (2016) (40)
Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells (2020) (40)
Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (2021) (40)
A Membrane-proximal Tetracysteine Motif Contributes to Assembly of CD3δϵ and CD3γϵ Dimers with the T Cell Receptor* (2006) (39)
In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange1 (2009) (39)
Signaling by the Epstein–Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses (2018) (39)
Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. (2020) (38)
Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy (2022) (38)
Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules (2004) (38)
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma (2021) (37)
Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop (2013) (36)
Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. (1998) (34)
Response Multilayered Control of T Cell Receptor Phosphorylation (2010) (34)
Immunotherapy for glioblastoma: on the sidelines or in the game? (2017) (34)
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses (2018) (34)
A Review of T‐Cell Receptors in Multiple Sclerosis: Clonal Expansion and Persistence of Human T‐Cells Specific for an Immunodominant Myelin Basic Protein Peptide a (1995) (33)
Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure (2001) (33)
Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation (2004) (33)
Inhibition of CDK4/6 promotes CD8 T-cell memory formation. (2021) (32)
Systematic Investigation of Cytokine Signaling Activity at the Tissue and Single-Cell Level (2021) (32)
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer (2020) (29)
Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function (2014) (28)
Mechanism of EBV inducing anti-tumour immunity and its therapeutic use (2020) (28)
Infectious triggers for inflammatory neurological diseases (2002) (24)
A vaccine targeting resistant tumours by dual T cell plus NK cell attack (2022) (23)
The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination. (2005) (23)
Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells (2020) (23)
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets (2021) (22)
Expansion and Contraction of HIV-Specific CD4 T Cells with Short Bursts of Viremia, but Physical Loss of the Majority of These Cells with Sustained Viral Replication1 (2005) (22)
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function (2022) (20)
Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma (2018) (20)
MHC‐Linked Susceptibility to Type 1 Diabetes (2003) (20)
Immunomodulation for glioblastoma (2017) (20)
Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity (2018) (19)
Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis (2022) (19)
CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor cells and T cells. (2021) (19)
Presentation of a Self-peptide in Two Distinct Conformations by a Disease-associated HLA-B27 Subtype (2004) (18)
Faculty Opinions recommendation of Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. (2005) (17)
Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity. (2019) (17)
Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. (2011) (17)
MHC-II neoantigens shape tumour immunity and response to immunotherapy (2019) (17)
The Solvent-Inaccessible Cys67 Residue of HLA-B27 Contributes to T Cell Recognition of HLA-B27/Peptide Complexes1 (2004) (16)
MHC-linked susceptibility to type 1 diabetes: a structural perspective. (2003) (16)
Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors (2020) (15)
Expression of the B7.1 Costimulatory Molecule on Pancreatic β Cells Abrogates the Requirement for CD4 T Cells in the Development of Type 1 Diabetes1 (2004) (15)
Genetic screens to study the immune system in cancer. (2016) (14)
Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. (2007) (14)
cIAP1/2 antagonism eliminates MHC class I–negative tumors through T cell–dependent reprogramming of mononuclear phagocytes (2021) (12)
Complexed with a Peptide from Human Myelin Basic Protein (1998) (11)
The First Structures of T Cell Receptors Bound to Peptide–MHC (2010) (10)
Visualization and quantification of NK cell-mediated cytotoxicity over extended time periods by image cytometry. (2019) (9)
Cutting Edge: CD4CD25 Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis 1 (2005) (9)
Immunosuppressive Myeloid Cells Induce Nitric Oxide–Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells (2021) (9)
Frontline: Self‐peptides that bind with low affinity to the diabetes‐associated I‐Ag7 molecule readily induce T cell tolerance in non‐obese diabetic mice (2004) (7)
MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia. (2021) (6)
Effect of dexamethasone in glioblastoma (GBM) patients on systemic and intratumoral T-cell responses induced by personalized neoantigen-targeting vaccine. (2018) (6)
Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. (2004) (6)
The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple Sclerosis (1991) (6)
Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasion (2020) (6)
Mechanical checkpoint regulates monocyte differentiation in fibrotic niches (2022) (6)
Cracking the code of human T-cell immunity (2013) (6)
mRNA duplexes by human Ago proteins − Alternative RISC assembly : Binding and repression of microRNA Material Supplemental (2012) (5)
The Structure of the zz Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor (5)
Positively selecting peptides: their job does not end in the thymus (2009) (5)
Human Fetal Liver ' y / ~ T Cells Predominantly Use Unusual Rearrangements of the T Cell Receptor and " y Loci Expressed on Both CD 4 + CD 8-and C D 4C D 8-T Cells (2003) (5)
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response (2018) (5)
Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET. (2017) (4)
Rapid T Cell Response to Vaccination Can Occur without Antibody Response in Children Post HSCT. (2004) (4)
Immunologic mechanisms in chronic demyelinating diseases of the central and peripheral nervous system. (1990) (4)
MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma (2022) (4)
Target discovery for T cell therapy: next steps to advance Immunotherapies (2015) (4)
Inhibition of MAN2A1 enhances tumor response to anti-PD-L1. (2020) (3)
Engineered myelin basic protein (MBP)-specific human T regulatory cells ameliorate myelin oligodendrocyte glycoprotein (MOG) peptide-induced Experimental Autoimmune Encephalomyelitis in vivo (2017) (3)
Integrin avb6–TGFb–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer (2020) (3)
Abstract 5631: Personal neoantigen-targeting vaccination generates neoepitope-specific T cell responses in tumors of patients with glioblastoma (2018) (3)
Dual Chimeric Antigen Receptor Approach Combining Novel Tumor Targeting Strategies Circumvents Antigen Escape in Multiple Myeloma (2021) (3)
Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers (2019) (3)
Designing Cancer Immunotherapies That Engage T Cells and NK Cells. (2022) (3)
Autoimmune diseases have been the focus of intense research efforts. (2011) (3)
Cytokine conjugation to enhance T cell therapy. (2022) (3)
Myelin-specific Regulatory T Cells Accumulate in the Central Nervous System, but Fail to Suppress Pathogenic Effector T Cells at the Peak of Autoimmune Inflammation (2007) (3)
The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity (2022) (2)
A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma (2022) (2)
Abstract 1591: FT536: Preclinical development of a novel off-the-shelf CAR-MICA/B NK cell immunotherapy combined with radiation and antibody treatments as a first-of-kind pan-cancer targeting strategy (2021) (2)
Breast cancer prevention by short-term inhibition of TGFβ signaling (2022) (2)
RHEUMATIC DISEASES Immunological mechanisms and prospects for new therapies (1999) (2)
Discovering cancer immunotherapy targets in vivo (2014) (2)
SclerosisMyelin Surface Antigen in Pediatric Multiple Age-Dependent B Cell Autoimmunity to a (2009) (2)
Landscape of B cell immunity and related immune evasion in human cancers (2019) (1)
Faculty Opinions recommendation of Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. (2005) (1)
2 - Implications of T Cell Receptor Crossreactivity for the Pathogenesis of Autoimmune Diseases (2004) (1)
Multilayered Control of T Cell Receptor Phosphorylation Response (2010) (1)
First-in-human CAN-3110 (ICP-34.5 expressing HSV-1 oncolytic virus) in patients with recurrent high-grade glioma. (2021) (1)
Crystal structure of a human insulin peptide-HLA-DQ8 complex (2001) (1)
Immune-Tumor Interactions in Resistance to Cancer Immunotherapy (2019) (1)
HLA and Autoimmunity (2006) (1)
Crystal structure of HLA-DM (2006) (1)
The structure and function of antigen receptors (2007) (1)
Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P VVHFFKNIVTP in chronic progressive (1997) (1)
Development of a Novel MICA/B-Specific CAR As a Pan-Tumor Targeting Strategy for Off-the-Shelf, Cell-Based Cancer Immunotherapy (2020) (1)
The role of MHC class II polymorphisms for DM-mediated peptide editing and autoimmunity (2017) (1)
Corrigendum: S100-alarmin-induced innate immune programming protects newborn infants from sepsis (2017) (1)
Analysis of αβ and γδ T cell receptors in multiple sclerosis plaques (1991) (1)
Mechanical Checkpoint Regulates Monocyte Differentiation in Fibrotic Matrix (2021) (1)
Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection (2017) (1)
117 FT536 Path to IND: Ubiquitous targeting of solid tumors with an off-the-shelf, first-of-kind MICA/B-specific CAR-iNK cellular immunotherapy (2021) (1)
TAMI-12. CANCER-IMMUNE CELL INTERACTIONS DRIVE TRANSITIONS TO MESENCHYMAL-LIKE STATES IN GLIOBLASTOMA (2021) (0)
Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer (2022) (0)
Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance (2019) (0)
Structure and Function of TCRαβ Receptors (2016) (0)
Molecule HLA-DQ 8 Myocarditis Using the Human MHC A Spontaneous Model for Autoimmune (2004) (0)
Rheumatic Diseases: The role of T cells in autoimmune disease (1999) (0)
Local changes in lipid environment of T cell receptor microclusters regulate membrane binding by the CD3epsilon cytoplasmic domain (P1103) (2013) (0)
Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers (2019) (0)
EPEN-21. IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION IN PEDIATRIC EPENDYMOMA REVEALED BY SINGLE-CELL RNA-SEQ (2020) (0)
Altered Synapse Formation by Self-reactive T Cells from MS Patients (2010) (0)
Structure of Zeta-Zeta Transmembrane Dimer (2006) (0)
Mechanism of EBV inducing anti-tumour immunity and its therapeutic use (2020) (0)
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses (2018) (0)
T Cell Receptor Va-Vo Repertoire and Cytokine Gene Expression in Active Multiple Sclerosis Lesions (2003) (0)
Structural basis of DAP12-associated intramembrane immunoreceptor assembly. (138.16) (2010) (0)
Movie S7. Time-Lapse Imaging Shows the Interaction of WT DCs with Pdpn−/− FRCs Cultured in 3D Matrix (2012) (0)
Role of Disorder in T-Cell Signaling (2012) (0)
Crystal structure of an immune complex (2013) (0)
EPCO-35. SINGLE-CELL RNA-SEQ OF PEDIATRIC EPENDYMOMA REVEALS PROGNOSTIC IMPACT OF IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION (2020) (0)
Polarized release and retroviral subversion of TCR-enriched microvesicles at the T cell immunological synapse (P6155) (2013) (0)
Abstract 2068: A highly selective dual Haspin-kinase and PIM-inhibitor overcomes RAF/MEK-inhibitor resistance in melanoma (2019) (0)
OTME-8. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis (2021) (0)
Movie S4. Time-Lapse Imaging Shows DCs Approaching Branched FRCs in 3D Matrix (2012) (0)
Inhibition of MICA and MICB Shedding Enhances Cytokine-Induced Memory-like NK Cell-Mediated Activity Against Multiple Myeloma (2022) (0)
Reply (1991) (0)
OTME-7. Cancer - immune cell interactions drive transitions to mesenchymal-like state in glioblastoma (2021) (0)
HLA-B 27 / Peptide Complexes HLA-B 27 Contributes to T Cell Recognition Residue of 67 The Solvent-Inaccessible (2004) (0)
Abstract 5387: Novel targeted single-cell TCR sequencing method used for analysis of a T cell infiltrate from a glioblastoma patient (2018) (0)
Advances in Brief Equivalent Induction of Telomerase-specific Cytotoxic T Lymphocytes from Tumor-bearing Patients and Healthy Individuals 1 (2001) (0)
Structural Characterization of an Unusual Binding Mode of a Myelin-specific T Cell Receptor (2010) (0)
Structural Basis of T-Cell Receptor Specificity and Cross-Reactivity: Implications for Pathogenesis of Human Autoimmune Diseases (2000) (0)
F.14. Autoantibodies to Myelin Oligodendrocyte Glycoprotein in Pediatric MS (2008) (0)
Susceptibility of MHC Class II / Peptide Structural Factors Contributing to DM (2002) (0)
Invariant Chain Peptide Precursors /Class II-Associated g7 Generated from I-A Nonobese Diabetic Mice with Tetramers Ex Vivo Analysis of Thymic CD4 T Cells in (2003) (0)
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial (2018) (0)
Movie S6. Time-Lapse Imaging Shows the Interaction of Clec1b−/− DCs with WT FRCs Cultured in 3D Matrix (2012) (0)
HLA and Autoimmunity: Structural Basis of Immune Recognition (2006) (0)
Abstract A176: Overcoming CD8 T-cell suppression in the tumor microenvironment (2019) (0)
Abstract 4174: Augmenting NK cell based immunotherapy by targeting mitochondrial apoptosis (2022) (0)
Helicobacter Pylori Infection and Immunity Edited by Yoshimasa Yamamoto, Herman Friedman, Paul S. Hoffman, Kluwer Academic/Plenum Publishers, New York, Price: $135.00 (2002) (0)
Structure of the DAP12-NKG2C transmembrane heterotrimer (2010) (0)
Crystal structure of HLA-DM bound to HLA-DR1 (2013) (0)
Oplöselige monovalent and multivalent MHC Class II fusion proteins, and uses thereof (1997) (0)
Crystallization of the complex of HLA-DR2 with immunodominant myelin basic protein peptide (1998) (0)
Ablated intestinal stem cells recover predominantly by ASCL2-dependent dedifferentiation of their recent progeny (2020) (0)
II Molecules Antigens Presented by Different MHC Class Cross-Reactive TCR Responses to Self (2004) (0)
Efficient Activation of Self-reactive T Cells from MS Patients with Altered Synapse Formation (2010) (0)
P-021: 7C6 is a novel monoclonal antibody that induces enhanced anti-myeloma activity of cytokine induced memory-like (CIML) NK cells by blocking MICA/B shedding and antibodydependent cell cytotoxicity (2022) (0)
COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UNE INFECTION À ARÉNAVIRUS (2017) (0)
Abstract A146: Systematic discovery of immune regulatory mechanisms in tumor cells (2019) (0)
Engineered MBP antigen-specific human regulatory T cells: direct and bystander immunosuppressive function (THER7P.954) (2015) (0)
Modulating MHC Class II Antigen Processing in Dendritic Cells Prevents Diabetes in NOD mice (78.25) (2009) (0)
Development of Type 1 Diabetes Requirement for CD 4 T Cells in the Cells Abrogates the β Molecule on Pancreatic Expression of the B 7 . 1 (2004) (0)
Myelin specific regulatory T cells expand from naturally occurring regulatory T cells and accumulate in the CNS during EAE (128.8) (2007) (0)
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity (2017) (0)
X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase (2002) (0)
vy 6 T-cell receptor repertoire in acute multiple sclerosis lesions (0)
Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines. (2023) (0)
Radiotherapy induces responses of lung cancer to CTLA-4 blockade (2018) (0)
114 Preclinical development of a novel iPSC-derived CAR-MICA/B NK cell immunotherapy to overcome solid tumor escape from NKG2D-mediated mechanisms of recognition and killing (2020) (0)
Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer (2020) (0)
HTLV-1 induced spontaneous T cell clonal proliferation is rapamycin sensitive (1991) (0)
Movie S2. Confocal Time-Lapse Imaging of DC Motility in LN Slices from WT BM → Ub-GFP Mice (2012) (0)
Correction: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells (2020) (0)
Structure of the DAP12 transmembrane homodimer (2010) (0)
Movie S5. Time-Lapse Imaging Shows the Migration of WT DCs along WT FRCs Cultured in 3D Matrix (2012) (0)
Small molecule enhancers of peptide binding to MHC class II: Implications for DM function (130.40) (2010) (0)
EncephalomyelitisSusceptibility to Experimental Autoimmune Cells Contribute to Gender Differences in Regulatory T + CD25+ Cutting Edge: CD4 (2005) (0)
Isolation of human anti-MICA antibody from cancer patients responding to immunotherapies. (2012) (0)
Sustained Viral Replication Physical Loss of the Majority of These Cells with T Cells with Short Bursts of Viremia , but Expansion and Contraction of HIV-Specific CD 4 (2005) (0)
ATIM-32. PERSONALIZED NEOANTIGEN-TARGETING VACCINE GENERATES ROBUST SYSTEMIC AND INTRATUMORAL T CELL RESPONSES IN GLIOBLASTOMA (GBM) PATIENTS (2018) (0)
A structural platform for B cell receptor signaling (2022) (0)
395 Detection of viral antigen and immune activation after intra-tumor injection of CAN-3110 (ICP-34.5 expressing HSV-1 oncolytic virus) in patients with recurrent high-grade glioma (2021) (0)
A vaccine targeting resistant tumours by dual T cell plus NK cell attack (2022) (0)
Development and Function Domain Is Required for Optimal T Cell Signaling ε Membrane Association of the CD 3 Vignali (2014) (0)
antigen-presenting cells: potential for clinical application efficiently induced by means of CD40-activated B cells as Human primary and memory cytotoxic T lymphocyte responses are (2013) (0)
Abstract A055: Systematic discovery of combinationimmunotherapy targets in vivo (2016) (0)
Oligodendrocyte Glycoprotein System Tissue Recognize Myelin Antibodies from Inflamed Central Nervous (2005) (0)
Fusion proteins of MHC class II, soluble, monovalent or polyvalent, and their uses. (1997) (0)
TCR/HLA-DR2b/MBP-peptide complex (2005) (0)
The First Structures of T Cell Receptors (2010) (0)
Peptide Recognition That Determine the Degree of Degeneracy in Structural Features of Autoreactive TCR (1998) (0)
Faculty Opinions recommendation of NKG2D blockade prevents autoimmune diabetes in NOD mice. (2004) (0)
A Novel Combination of TGF-β Inhibitor and DC/AML Fusion Vaccine for Management of AML in an Immunocompetent Murine Model (2022) (0)
Arthritis-Associated HLA-DR Molecules Sclerosis- and Rheumatoid Binding Motifs of Copolymer 1 to Multiple (1999) (0)
Abstract SY45-04: Development of therapeutic strategies by resolving the tumor ecosystem (2019) (0)
Correction (1912) (0)
Mouse CD3epsilon Cytoplasmic Tail (2008) (0)
Potential of antigen-specific adoptive immunotherapy using peptide/mhc tetramers and microbeads for highyield purification of cytotoxic t lymphocytes from peripheral blood (2000) (0)
Abstract 4190: Combining dual CAR iPSC-derived immune cells with antibody for multi-antigen targeting to overcome clonal resistance in multiple myeloma (2022) (0)
Abstract B132: Inhibition of Haspin kinase to promote cell-intrinsic and extrinsic anticancer therapy (2019) (0)
Abstract 700: CellSig: A data-driven model of cytokine activity identifies therapeutic targets for severe COVID-19 and cancer immunotherapy-induced colitis (2021) (0)
Su.32. Myelin-specific Regulatory T Cells Accumulatein the Central Nervous System, but Fail to Suppress Pathogenic Effector T Cells at the Peak of Autoimmune Inflammation [abstract only] (2007) (0)
Crystal structure of an immune complex at pH 6.5 (2013) (0)
Abstract 2325: Long term time-course monitoring of NK cell-mediated ADCC using the Celigo Image Cytometer (2019) (0)
Crystal structure of a autoimmune TCR-MHC complex (2013) (0)
Detection of autoantibodies with self-assembling radiolabeled antigen tetramers (2007) (0)
Faculty Opinions recommendation of Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. (2005) (0)
Polarized release of TCR‐enriched microvesicles at the center of the T cell immunological synapse (2013) (0)
Peptide independent assembly of HLA-DR2 molecules from subunits expressed in E. coli (1994) (0)
204 Combining FT536, a pan-tumor targeting CAR NK cell therapy, with CD16 engagers provides a coordinated targeting strategy to overcome tumor heterogeneity (2022) (0)
Abstract P2-14-18: A randomized phase II trial of carboplatin with or without nivolumab in metastatic triple-negative breast cancer (2022) (0)
Gene Activation During Experimental Allergic Encephalomyelitis (1988) (0)
Structure of Autoimmune TCR Hy.1B11 in complex with HLA-DQ1 and MBP 85-99 (2010) (0)

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