Kalle Saksela

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Kalle Saksela is affiliated with the following schools: Tampere University, Rockefeller University, University of Turku, University of Helsinki

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Kalle Saksela

Biology

#12973

World Rank

#16484

Historical Rank

Virology

#357

World Rank

#365

Historical Rank

biology Degrees

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Biology

Kalle Saksela's Degrees

PhD Virology University of Helsinki
Doctorate Medicine University of Helsinki

Why Is Kalle Saksela Influential?

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According to Wikipedia, Kalle M. Saksela is a Finnish virologist. He has been a professor at University of Helsinki since 2005, where he leads the virology department. Biography and work in 1989 Saksela obtained his MD and PhD from the University of Helsinki under the supervision of Kari Alitalo. In 1989/1990 Saksela was research fellow with Helsinki's department of virology. In 1991 Saksela worked as a postdoctoral fellow with David Baltimore at the Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, and then followed him to the Rockefeller University. There he worked as an assistant professor From 1994 to 1996. After that he returned to Finland to become a professor for molecular medicine with the Institute for Medical Technology at the University of Tampere, but until 2000 he also remained an adjunct professor with James E. Darnell's laboratory at The Rockefeller University. 2005 Saksela moved to Helsinki to become a professor of virology at the University of Helsinki and the chairman of its virology department. In addition he also became the chief physician of the University Hospital's HUSLAB.

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Kalle Saksela's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Decay characteristics of HIV-1-infected compartments during combination therapy (1997) (1893)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
Proline‐rich (PxxP) motifs in HIV‐1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down‐regulation of CD4. (1995) (585)
Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain (1996) (427)
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV‐1 Nef protein. (1995) (270)
Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses (1994) (216)
SH3 domain ligand binding: What's the consensus and where's the specificity? (2012) (201)
High-throughput phosphotyrosine profiling using SH2 domains. (2007) (171)
The Hepatitis C Virus Non-structural NS5A Protein Inhibits Activating Protein–1 Function by Perturbing Ras-ERK Pathway Signaling* (2003) (170)
Interactions of HIV-1 NEF with cellular signal transducing proteins. (2000) (166)
Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines. (2008) (163)
Identification of the Nef-associated kinase as p21-activated kinase 2 (1999) (153)
myc oncogenes: activation and amplification. (1987) (145)
Generation of a Conditionally Replicating Adenovirus Based on Targeted Destruction of E1A mRNA by a Cell Type-Specific MicroRNA (2008) (142)
Human immunodeficiency virus type 1 mRNA expression in peripheral blood cells predicts disease progression independently of the numbers of CD4+ lymphocytes. (1994) (131)
Identification of preferred protein interactions by phage‐display of the human Src homology‐3 proteome (2006) (125)
Synergistic Activation of NFAT by HIV-1 Nef and the Ras/MAPK Pathway* (2000) (123)
SH3 Domain-Mediated Recruitment of Host Cell Amphiphysins by Alphavirus nsP3 Promotes Viral RNA Replication (2011) (123)
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspFU during pedestal formation (2009) (120)
SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. (1998) (112)
Avian and 1918 Spanish Influenza A Virus NS1 Proteins Bind to Crk/CrkL Src Homology 3 Domains to Activate Host Cell Signaling* (2008) (103)
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. (2005) (94)
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases. (2013) (93)
ACUTE MYELOGENOUS LEUKAEMIA WITH C-MYC AMPLIFICATION AND DOUBLE MINUTE CHROMOSOMES (1985) (92)
HIV-1 Nef Interacts with Inositol Trisphosphate Receptor to Activate Calcium Signaling in T Cells (2002) (89)
Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element (1993) (88)
High viral load in lymph nodes and latent human immunodeficiency virus (HIV) in peripheral blood cells of HIV-1-infected chimpanzees (1993) (83)
Heat shock protects WEHI‐164 target cells from the cytolysis by tumor necrosis factors α and β (1989) (82)
Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6. (2000) (79)
HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection (2016) (75)
Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer. (1985) (73)
Reciprocal Regulation of SH3 and SH2 Domain Binding via Tyrosine Phosphorylation of a Common Site in CD3ε1 (2007) (72)
Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events. (1999) (67)
Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity (2007) (66)
Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly (2010) (66)
HIV-1 Messenger RNA in Peripheral Blood Mononuclear Cells as an Early Marker of Risk for Progression to AIDS (1995) (65)
Dystroglycan, Tks5 and Src Mediated Assembly of Podosomes in Myoblasts (2008) (64)
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role (2009) (64)
T cell circuits that sense antigen density with an ultrasensitive threshold (2021) (62)
Human Immunodeficiency Virus Type 1 Nef Selectively Associates with a Catalytically Active Subpopulation of p21-Activated Kinase 2 (PAK2) Independently of PAK2 Binding to Nck or β-PIX (2001) (61)
Nef Proteins from Simian Immunodeficiency Virus-Infected Chimpanzees Interact with p21-Activated Kinase 2 and Modulate Cell Surface Expression of Various Human Receptors (2004) (57)
Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage. (2004) (57)
Activation of NFAT-Dependent Gene Expression by Nef: Conservation among Divergent Nef Alleles, Dependence on SH3 Binding and Membrane Association, and Cooperation with Protein Kinase C-θ (2001) (57)
Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan (2010) (55)
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors (2008) (53)
Activation of protein kinase C increases phosphorylation of the L-myc trans-activator domain at a GSK-3 target site. (1992) (52)
SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef. (1999) (50)
HIV-1 Nef and host cell protein kinases. (1997) (50)
Attenuation of Semliki Forest Virus Neurovirulence by MicroRNA-Mediated Detargeting (2012) (49)
Human immunodeficiency virus type-1 mRNA splicing pattern in infected persons is determined by the proportion of newly infected cells. (1997) (49)
Nef Associates with p21-Activated Kinase 2 in a p21-GTPase-Dependent Dynamic Activation Complex within Lipid Rafts (2004) (48)
A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells (2001) (48)
Cdc42/Rac1-Mediated Activation Primes PAK2 for Superactivation by Tyrosine Phosphorylation (2002) (46)
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling. (2005) (45)
Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue (2007) (39)
Unmodified Histone H3K4 and DNA-Dependent Protein Kinase Recruit Autoimmune Regulator to Target Genes (2012) (39)
The Mechanism of Tissue-Restricted Antigen Gene Expression by AIRE (2013) (38)
Structural basis of PxxDY motif recognition in SH3 binding. (2009) (38)
Stability in controlling viral replication identifies long-term nonprogressors as a distinct subgroup among human immunodeficiency virus type 1-infected persons (1996) (38)
Role of the Kaposi's Sarcoma-Associated Herpesvirus K15 SH3 Binding Site in Inflammatory Signaling and B-Cell Activation (2010) (38)
Hepatitis C Virus NS5A Inhibits Mixed Lineage Kinase 3 to Block Apoptosis* (2013) (35)
Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX. (2001) (35)
Interactions of the HIV/SIV pathogenicity factor Nef with SH3 domain-containing host cell proteins. (2011) (34)
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene (1989) (33)
The myc proteins are not associated with chromatin in mitotic cells. (1984) (33)
Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. (2012) (31)
Conformation of the Dileucine‐Based Sorting Motif in HIV‐1 Nef Revealed by Intermolecular Domain Assembly (2011) (31)
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription (2011) (31)
Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2* (2016) (30)
MicroRNA-Mediated Suppression of Oncolytic Adenovirus Replication in Human Liver (2013) (30)
Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB. (2003) (30)
Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development (2011) (29)
Amplification of the N‐myc oncogene in an adenocarcinoma of the lung (1986) (29)
A Generic, Scalable, and Rapid Time-Resolved Förster Resonance Energy Transfer-Based Assay for Antigen Detection—SARS-CoV-2 as a Proof of Concept (2021) (28)
Rapid phosphorylation of the L‐myc protein induced by phorbol ester tumor promoters and serum. (1989) (28)
MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma (2015) (28)
A fusion protein formed by L‐myc and a novel gene in SCLC. (1991) (28)
Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins (2009) (27)
Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains. (2001) (26)
Human viruses under attack by small inhibitory RNA. (2003) (25)
Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex (2015) (23)
Oncogene expression in small‐cell lung cancer cell lines and a testicular germ‐cell tumor: Activation of the N‐myc gene and decreased RB mRNA (1989) (22)
Activation of p21-activated Kinase 2 and Its Association with Nef Are Conserved in Murine Cells but Are Not Sufficient to Induce an AIDS-like Disease in CD4C/HIV Transgenic Mice* (2006) (22)
HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles (2018) (22)
Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions (2012) (22)
Optimized Mouse Model for the Imaging of Tumor Metastasis upon Experimental Therapy (2011) (21)
Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro (2022) (20)
High-Affinity Target Binding Engineered via Fusion of a Single-Domain Antibody Fragment with a Ligand-Tailored SH3 Domain (2012) (20)
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody (2014) (20)
Versatile retargeting of SH3 domain binding by modification of non‐conserved loop residues (2007) (19)
Preferred SH3 Domain Partners of ADAM Metalloproteases Include Shared and ADAM-Specific SH3 Interactions (2015) (18)
Amplification and rearrangement of L-myc in human small-cell lung cancer. (1992) (18)
Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factors alpha and beta. (1989) (18)
Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function (2012) (18)
A single-chain antibody/epitope system for functional analysis of protein-protein interactions. (2002) (17)
Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction (2015) (17)
Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant (2021) (17)
Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine show antiviral activity against the novel variants in vitro (2021) (16)
myc Genes and their deregulation in lung cancer (1990) (16)
The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice. (2015) (15)
A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression. (2001) (15)
Comprehensive Analysis of Interactions between the Src-Associated Protein in Mitosis of 68 kDa and the Human Src-Homology 3 Proteome (2012) (15)
Capacity of simian immunodeficiency virus strain mac Nef for high-affinity Src homology 3 (SH3) binding revealed by ligand-tailored SH3 domains. (2002) (14)
Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion (2019) (14)
Indoor Model Simulation for COVID-19 Transport and Exposure (2021) (13)
Reorganization of the host cell Crk(L)-PI3 kinase signaling complex by the influenza A virus NS1 protein. (2015) (12)
Expression of the L-myc gene is under positive control by short-lived proteins. (1987) (11)
Therapeutic targeting of interactions between Nef and host cell proteins. (2004) (11)
Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems. (2016) (11)
Plasma proteins, cognitive decline, and 20‐year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies (2021) (10)
Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands* (2016) (7)
Human Immunodeﬁciency Virus Type 1 Nef Selectively Associates with a Catalytically Active Subpopulation of p21-Activated Kinase 2 (PAK2) Independently of PAK2 Binding to Nck or b -PIX (2001) (7)
Negative Regulation ofImmunoglobulin KappaLight-Chain GeneTranscription bya ShortSequence Homologous totheMurineBiRepetitive Element (1993) (7)
Preferred SH 3 Domain Partners of ADAM Metalloproteases Include Shared and ADAM-Specific SH 3 Interactions (7)
Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms (2013) (6)
Binding of a nuclear factor to the upstream region of the c-myc gene. (1991) (5)
A generic, scalable, and rapid TR-FRET -based assay for SARS-CoV-2 antigen detection (2020) (5)
Blood and saliva SARS-CoV-2 antibody levels in self-collected dried spot samples (2022) (5)
ANKRD54 preferentially selects Bruton’s Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library (2017) (4)
Screening Assay for the Detection of the Protein-Protein Interaction Between HIV-1 Nef Protein and the SH3 Domain of Hck (1998) (4)
MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction (2019) (4)
Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein (2016) (4)
myc, max, and a novel rlf-L-myc fusion protein in small-cell lung cancer. (1991) (3)
Association of plasma proteins with rate of cognitive decline and dementia: 20-year follow-upof the Whitehall II and ARIC cohort studies (2020) (2)
Intranasal inhibitor blocks omicron and other variants of SARS-CoV-2 (2021) (2)
HIV-1 Nef-Induced Secretion of the Proinflammatory Protease TACE into Extracellular Vesicles Is Mediated by Raf-1 and Can Be Suppressed by Clinical Protein Kinase Inhibitors (2021) (2)
ANKRD 54 preferentially selects Bruton ' s Tyrosine Kinase ( BTK ) from a Human Src-Homology 3 ( SH 3 ) domain library (1)
Oncogene Amplification (2020) (1)
Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage (2021) (1)
SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study (2023) (1)
Essential role of c-Abl PxxP motifs and its interactions with Crk and Nck adaptors in cell spreading (2019) (1)
Supplemental Data High-Throughput Phosphotyrosine Profiling Using SH 2 Domains (2007) (1)
[Pathogenesis of HIV infections]. (1996) (0)
Table of Contents (1991) (0)
Human immunodeficiency virus type 1 mRNA expression in peripheral blood cells predicts disease progression independently of the numbers of CD4+ lymphocytes (acquired immunodeficiency syndrome/polymerase chain reaction/3'-azido-3'-deoxythymidine) (2016) (0)
[HIV infection can be treated]. (1997) (0)
HIV-1 RNA in blood and pathogenesis of HIV infection. (1995) (0)
Phosphorylation of a Common Site in CD 3 Domain Binding via Tyrosine Reciprocal Regulation of SH 3 and SH 2 (2007) (0)
Amphiphysin SH3 in complex with Chikungunya virus nsP3 peptide (2016) (0)
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody (2014) (0)
A single aminoacidintheSH3domainofHck determines itshighaffinity andspecificity inbinding toHIV-1Nefprotein (1995) (0)
Table of Contents (1989) (0)
Nef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV (2011) (0)
[RNA interference in the prevention of viral diseases?]. (2002) (0)
Structure of amphiphysin SH 3 in complex with a CHIKV nsP 3 peptide 1 Structural Basis of the High-Affinity Interaction Between the Alphavirus Nonstructural Protein-3 ( nsP 3 ) and the SH 3 Domain of Amphiphysin-2 (2016) (0)
Comparison of Automated and Traditional Western Blotting Methods (2023) (0)
Oncogene amplification: Myc and neu oncoproteins (2018) (0)
Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants (2023) (0)
Intranasal inhibitor broadly blocks SARS-CoV-2 including recent highly immunoevasive Omicron subvariants (2022) (0)
Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs. (2022) (0)
RATIONAL ENGINEERING OF microRNA-REGULATED VIRUSES FOR CANCER GENE THERAPY (2013) (0)
Process for the preparation of a fusion polypeptide (2007) (0)
Lymphocytes + Disease Progression Independently of the Numbers of CD 4 Human Immunodeficiency Virus Type 1 mRNA Expression in Peripheral Blood Cells Predicts (2004) (0)
Oncogenes: from bursal to Burkitt lymphoma (1987) (0)
1H, 13C, and 15N Chemical Shift Assignments for IRTKS-SH3 and EspFu-R47 complex (2010) (0)
Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms (2013) (0)
Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function (2012) (0)
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models (2023) (0)
Ligand Recognition in SH 3-mediated Protein Interactions (2005) (0)
Gene Expression by AIRE The Mechanism of Tissue-Restricted Antigen (2013) (0)
Amplification of Cellular Oncogenes in Colon and Lung Cancer Cells (1985) (0)
SARS-CoV-2 and Type 1 Diabetes in Finnish Children (2022) (0)
Disease Progression Independently of the Numbers of CD4 Human Immunodeficiency Virus Type 1 mRNA Expression in Peripheral Blood Cells Predicts (2006) (0)

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