Karen Ashe
#46,585
Most Influential Person Now
Professor:Department of Neurology/Neuroscience:University of Minnesota
Karen Ashe's AcademicInfluence.com Rankings
Karen Ashemedical Degrees
Medical
#833
World Rank
#1090
Historical Rank
Neurology
#178
World Rank
#248
Historical Rank
Karen Ashebiology Degrees
Biology
#4124
World Rank
#6197
Historical Rank
Neuroscience
#770
World Rank
#802
Historical Rank
Download Badge
Medical Biology
Why Is Karen Ashe Influential?
(Suggest an Edit or Addition)According to Wikipedia, Karen K. Hsiao Ashe is a professor at the Department of Neurology and Neuroscience at the University of Minnesota Medical School, where she holds the Edmund Wallace and Anne Marie Tulloch Chairs in Neurology and Neuroscience. She is the founding director of the N. Bud Grossman Center for Memory Research and Care, and her specific research interest is memory loss resulting from Alzheimer's disease and related dementias. Her research has included the development of an animal model of Alzheimer's.
Karen Ashe's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A specific amyloid-β protein assembly in the brain impairs memory (2006) (2572)
- Natural oligomers of the amyloid-β protein specifically disrupt cognitive function (2005) (1668)
- Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function (2005) (1366)
- A specific amyloid-beta protein assembly in the brain impairs memory. (2006) (1267)
- Propagation of Tau Pathology in a Model of Early Alzheimer's Disease (2012) (1040)
- Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease (2000) (920)
- Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease (2001) (904)
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration (2010) (854)
- Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model (2004) (708)
- The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease (2002) (645)
- Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L) (2005) (572)
- β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:In Vitro and In Vivo Mechanisms Related to Alzheimer's Disease (2001) (478)
- Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy (2007) (458)
- Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease (2002) (440)
- Probing the Biology of Alzheimer's Disease in Mice (2010) (415)
- Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. (2001) (412)
- Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. (2006) (382)
- Brain amyloid-β oligomers in ageing and Alzheimer's disease. (2013) (367)
- Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models* (2007) (352)
- The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. (2002) (326)
- Extended results of the Alzheimer’s disease anti-inflammatory prevention trial (2011) (317)
- Evidence for glial-mediated inflammation in aged APPSW transgenic mice (1999) (297)
- Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease (2004) (295)
- Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. (2008) (254)
- Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. (2000) (242)
- Learning and memory in transgenic mice modeling Alzheimer's disease. (2001) (238)
- Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. (2001) (226)
- Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease (2002) (224)
- The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. (2005) (223)
- Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. (2008) (216)
- Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease (2012) (199)
- Motor dysfunction and gliosis with preserved dopaminergic markers in human α-synuclein A30P transgenic mice (2003) (185)
- ‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease? (2010) (175)
- Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. (2007) (174)
- Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function (2008) (166)
- Cognitive effects of cell-derived and synthetically derived Aβ oligomers (2011) (150)
- In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons (2008) (137)
- Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. (2004) (135)
- Caspase-2 cleavage of tau reversibly impairs memory (2016) (133)
- Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. (2015) (120)
- Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity (2007) (115)
- Genes contributing to prion pathogenesis. (2008) (114)
- Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice (2019) (92)
- Prions, prionoids and pathogenic proteins in Alzheimer disease (2013) (86)
- Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures (2008) (79)
- Commentary on “Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice” (2006) (67)
- Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults. (2013) (64)
- Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease. (2008) (62)
- Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment. (2015) (56)
- β-Amyloid oligomers in aging and Alzheimer’s disease (2013) (56)
- Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein (2000) (51)
- Age-Dependent Changes in Brain , CSF , and Plasma Amyloid b Protein in the Tg 2576 Transgenic Mouse Model of Alzheimer ’ s Disease (2001) (50)
- Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice. (2011) (48)
- Altered short-term hippocampal synaptic plasticity in mutant &agr;-synuclein transgenic mice (2003) (46)
- Mechanisms of memory loss in Aβ and tau mouse models (2005) (41)
- Amyloid- β Deposits Lead to Retinal Degeneration in a Mouse Model of Alzheimer Disease (2008) (35)
- Effect size of reference memory deficits in the Morris water maze in Tg2576 mice (2010) (34)
- Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies (2019) (33)
- Brain amyloid- b oligomers in ageing and Alzheimer’s disease (2013) (31)
- Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents (2014) (31)
- Mechanisms of memory loss in Abeta and tau mouse models. (2005) (30)
- Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein. (2000) (30)
- Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model. (1999) (26)
- Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. (2004) (25)
- Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. (2017) (24)
- Animal Model Age-Related Amyloid b Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid b Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss (2000) (23)
- Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile (2015) (20)
- The biogenesis and biology of amyloid β oligomers in the brain (2020) (20)
- b -Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal a 7 Nicotinic Acetylcholine Receptors: In Vitro and In Vivo Mechanisms Related to Alzheimer’s Disease (2001) (18)
- A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients (2019) (18)
- A tale about tau. (2007) (18)
- Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction (2019) (16)
- A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals (2020) (16)
- Synaptic Structure and Function in Transgenic APP Mice (2000) (15)
- A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease (2019) (15)
- Grape seed polyphenolic extract specifically decreases Aβ∗56 in the brains of Tg2576 mice (2010) (13)
- Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer's disease. (2006) (11)
- The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases? (2020) (11)
- Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau (2012) (9)
- Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments (2019) (8)
- Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice (2020) (7)
- Structure-Based Design and Biological Evaluation of Novel Caspase2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314 (2022) (7)
- Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice (2019) (6)
- A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins (2019) (6)
- In search of the molecular basis of memory loss in Alzheimer disease. (2006) (4)
- More than a FAD: The In Vivo Effects of Disease-Linked Presenilin-1 Mutations (2015) (4)
- S5-03-03 A specific amyloid-β assembly in the brain impairs memory (2006) (3)
- Neurobiology of disease (2011) (3)
- Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice (2021) (3)
- Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy. (2022) (3)
- Cognitive Impairment in Transgenic Aβ and Tau Models of Alzheimer’s Disease (2007) (3)
- Alzheimer's Disease: Transgenic Mouse Models (2009) (2)
- The sixth vital sign project: Is cognitive screening in the elderly population clinically effective? (2012) (2)
- P1-230 Natural, cell-derived Aβ oligomers: their production, biological activity and inhibition (2004) (2)
- Cellular prion protein and class-specific Aβ oligomers mediate plaque-associated cytopathology in a mouse model of Alzheimer’s disease (2015) (1)
- Characterization of caspase‐2 inhibitors based on specific sites of caspase‐2‐mediated proteolysis (2022) (1)
- Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia (2022) (1)
- Abeta dimers mediate plaque-associated cytopathology without affecting cognition (2011) (1)
- The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies (2021) (1)
- Naturally assembled Abeta oligomers produce cognitive deficits (2003) (1)
- Immunization against AB in APP overexpressing mice (2000) (1)
- Quantitative comparison of dense-core amyloid plaque burdens in Alzheimer’s disease patients and amyloid precursor protein transgenic mice (2015) (1)
- Caspase-2 mRNA levels are not elevated in mild cognitive impairment, Alzheimer’s disease, Huntington’s disease, or Lewy Body dementia (2022) (1)
- P4-334 Omega-3 fatty acid enriched diet reduces amyloid in an Alzheimer's disease mouse model (2004) (1)
- Alzheimer’s target still viable but untested (2022) (1)
- Creating APP Transgenic Lines in Mice (2004) (1)
- From prion diseases to Alzheimer's disease (1997) (1)
- A TAU CLEAVAGE PRODUCT, ΔTAU314, IS INCREASED IN ALZHEIMER’S DISEASE AND PARKINSON’S DISEASE WITH DEMENTIA (2018) (1)
- 3 Evidence in humans linking a specific amyloid-β oligomer to tau pathobiology (2012) (0)
- O2-04-01 COMBINED AMYLOID AND TAU-PATHOLOGY IN APPV717I X TAUP301L DOUBLE TRANSGENIC MICE: INCREASED SURVIVAL CORRELATES WITH LESS HINDBRAIN PATHOLOGY, DESPITE DRAMATIC FOREBRAIN TAUOPATHY (2006) (0)
- Type 1 and Type 2 Aβ oligomers in the brain (2016) (0)
- Decreased proliferation of endogenous neural stem cells in transgenic tau Alzheimer's mice (2006) (0)
- O2-04-02 Cognitive and pathological effects of regulatable tau in adult mice (2006) (0)
- Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer’s Disease (2023) (0)
- Role of APOE in Alzheimer's disease-like neurodegeneration (2000) (0)
- A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins (2019) (0)
- Specific Aβ oligomers and the tau/Aβ42 ratio correlate in lumbar puncture CSF (2011) (0)
- Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents (2014) (0)
- Mediation of synaptic dysfunction by tau mislocalisation to dendritic spines (2011) (0)
- Magnetic resonance biomarkers of neurodegeneration in a transgenic mouse model of Alzheimer's disease (2010) (0)
- P4-370 Long-term survival of human CNS stem cells and their progeny in immunodeficient, plaque-producing APP transgenic mice (2006) (0)
- A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease (2019) (0)
- The relevance of Quaternary structure to the functional effects of amyloid-β oligomers in the brain (2014) (0)
- O1-04-06 Identification of loci determining susceptibility to the lethal effects of APP transgene overexpression (2004) (0)
- Animal Models to Study the Biology of Amyloid‐β Protein Misfolding in Alzheimer Disease (2010) (0)
- Acknowledgement of Reviewers 2014 (2015) (0)
- Author Correction: A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals (2020) (0)
- ALZHEIMER’S DISEASE Advances in Genetics, Molecular and Cellular Biology ALZHEIMER’S DISEASE Advances in Genetics, Molecular and Cellular Biology (2013) (0)
- P4-368 NSAIDS improve amyloid beta protein-induced deficits in memory and synaptic plasticity (2004) (0)
- O4-03-05 Dietary omega-3 docosahexaenoic acid DHA regulates CNS insulin signaling and related kinase pathways involved in actin assembly, synaptic plasticity and memory in an Alzheimer (AD) model (2004) (0)
- Transmission of tau-induced cognitive dysfunction (2010) (0)
- Evolution of Brain Aβ Oligomers Interactomes during the Course of Alzheimer's Disease (2010) (0)
- PL-4-3 Animal models of AD (2004) (0)
- The mislocalization of tau to dendritic spines mediates synaptic dysfunction independent of neurodegeneration (2010) (0)
- Role of Amuloid Toxicity in Experimental AMD: I. Localization of APP and Amyloid–Beta Deposits in the Retina of the Bi–transgenic Mouse TG2576 X TG1 (2005) (0)
- Faculty Opinions recommendation of Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. (2008) (0)
- P1-095: CNS stem cell lines from tau transgenic mice as models for frontotemporal dementia (2008) (0)
- Quaternary Structure Defi nes a Large Class of Amyloid-b Oligomers Neutralized by Sequestration Graphical (2015) (0)
- S2-02-06 The tauopathies: From genetics to animal models (2006) (0)
- S2-02-05 Neuritic alterations and dysfunctions in Alzheimer’s disease (2006) (0)
- Forthcoming Articles (2020) (0)
- Faculty Opinions recommendation of Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. (2008) (0)
- DNA aptamers against specific oligomeric Aβ species (2010) (0)
- A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals (2020) (0)
- Specific alterations of tau phosphorylation and neuronal signaling induced by the amyloid-β oligomer Aβ*56 (2016) (0)
- Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias. (2022) (0)
- Aβ*56 is a stable oligomer that correlates with age-related memory loss in Tg2576 mice (2023) (0)
- Author Correction: A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals (2020) (0)
- NEURODEGENERATION IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE (0)
- Highly cited clinical and epidemiological papers on Alzheimer disease published in 2005 (2006) (0)
This paper list is powered by the following services:
Other Resources About Karen Ashe
What Schools Are Affiliated With Karen Ashe?
Karen Ashe is affiliated with the following schools:
