Karen Oegema | Academic Influence

Karen Oegema's AcademicInfluence.com Rankings

Karen Oegema

Biology

#5703

World Rank

#8246

Historical Rank

#1925

USA Rank

Cell Biology

#318

World Rank

#326

Historical Rank

#61

USA Rank

Molecular Biology

#2414

World Rank

#2451

Historical Rank

#249

USA Rank

biology Degrees

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Biology

Karen Oegema's Degrees

PhD Molecular Biology University of California, San Francisco
Bachelors Biology Stanford University

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Why Is Karen Oegema Influential?

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According to Wikipedia, Karen Oegema is a molecular cell biologist at the Ludwig Institute for Cancer Research and a professor of cellular and molecular medicine at the University of California, San Diego. She is best known for her research with Caenorhabditis elegans , which her lab uses as a model system in their mission to dissect the molecular mechanics of cytokinesis. She was given the Women in Cell Biology Mid-Career Award for Excellence in Research in 2017, as well as the Women in Cell Biology Junior Award for Excellence in Research in 2006.

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Karen Oegema's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans (2005) (912)
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III (2000) (906)
Functional Analysis of Kinetochore Assembly in Caenorhabditis elegans (2001) (458)
Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans (2001) (453)
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. (2004) (435)
Reversible centriole depletion with an inhibitor of Polo-like kinase 4 (2015) (329)
Characterization of Two Related Drosophila γ-tubulin Complexes that Differ in Their Ability to Nucleate Microtubules (1999) (326)
SAS-4 Is a C. elegans Centriolar Protein that Controls Centrosome Size (2003) (319)
Functional Analysis of a Human Homologue of the Drosophila Actin Binding Protein Anillin Suggests a Role in Cytokinesis (2000) (297)
Centriole assembly requires both centriolar and pericentriolar material proteins. (2004) (297)
Cytokinesis in animal cells. (2012) (289)
Katanin controls mitotic and meiotic spindle length (2006) (273)
KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. (2003) (254)
A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans (2005) (240)
Cytokinesis in eukaryotes: a mechanistic comparison. (1999) (239)
Functional genomics identifies a Myb domain–containing protein family required for assembly of CENP-A chromatin (2007) (228)
Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. (1998) (226)
The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is γ-tubulin dependent (2002) (216)
Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size (2009) (205)
Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. (2010) (200)
A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue (2011) (194)
Anillin and the septins promote asymmetric ingression of the cytokinetic furrow. (2007) (187)
Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis (2005) (185)
A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. (2008) (182)
A role for Rab5 in structuring the endoplasmic reticulum (2007) (182)
A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis (2010) (179)
Inhibition of Rac by the GAP Activity of Centralspindlin Is Essential for Cytokinesis (2008) (175)
Distinct roles for two C. elegans anillins in the gonad and early embryo (2005) (173)
"Holo"er than thou: Chromosome segregation and kinetochore function in C. elegans (2004) (164)
53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration (2016) (163)
Regulated assembly of a supramolecular centrosome scaffold in vitro (2015) (151)
The minus end in sight (2003) (151)
An inverse relationship to germline transcription defines centromeric chromatin in C. elegans (2012) (151)
A Bir1-Sli15 Complex Connects Centromeres to Microtubules and Is Required to Sense Kinetochore Tension (2006) (148)
Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore (2012) (141)
A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. (2007) (132)
SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the γ-tubulin–mediated addition of centriolar microtubules (2008) (125)
A Bub1–Mad1 interaction targets the Mad1–Mad2 complex to unattached kinetochores to initiate the spindle checkpoint (2014) (124)
Poleward Microtubule Flux Is a Major Component of Spindle Dynamics and Anaphase A in Mitotic Drosophila Embryos (2002) (121)
Acute Drug Treatment in the Early C. elegans Embryo (2011) (120)
Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. (2006) (114)
Hierarchical assembly of the eggshell and permeability barrier in C. elegans (2012) (109)
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2 (2006) (108)
Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly (2013) (96)
NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans (2015) (95)
The gene encoding ARS-binding factor I is essential for the viability of yeast. (1989) (92)
Rappaport rules: cleavage furrow induction in animal cells. (1997) (91)
The C. elegans RSA Complex Localizes Protein Phosphatase 2A to Centrosomes and Regulates Mitotic Spindle Assembly (2007) (91)
Uncoordinated Loss of Chromatid Cohesion Is a Common Outcome of Extended Metaphase Arrest (2011) (90)
Crosstalk Between Microtubule Attachment Complexes Ensures Accurate Chromosome Segregation (2013) (90)
Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. (2009) (88)
The CENP-F-like Proteins HCP-1 and HCP-2 Target CLASP to Kinetochores to Mediate Chromosome Segregation (2005) (88)
The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. (2009) (85)
A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. (2013) (85)
A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans (2017) (83)
Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 (Formerly TMEM188) Is the Metazoan Spo7p Ortholog and Functions in the Lipin Activation Pathway* (2011) (78)
Recruitment of the γ-Tubulin Ring Complex to Drosophila Salt-stripped Centrosome Scaffolds (1998) (76)
Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay (2006) (75)
A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions (2016) (73)
The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly (2011) (71)
The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes. (1995) (71)
The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains (1995) (71)
Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo. (2008) (67)
A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly. (2016) (66)
The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules (2013) (65)
Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown (2014) (63)
CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner. (1995) (60)
Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. (2013) (55)
The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans. (2014) (55)
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition (2020) (54)
Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190. (1997) (51)
A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans (2018) (51)
MVB-12, a Fourth Subunit of Metazoan ESCRT-I, Functions in Receptor Downregulation (2007) (50)
The CENP-A N-Tail Confers Epigenetic Stability to Centromeres via the CENP-T Branch of the CCAN in Fission Yeast (2015) (49)
Rapid De Novo Centromere Formation Occurs Independently of Heterochromatin Protein 1 in C. elegans Embryos (2011) (48)
TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis (2017) (47)
Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. (2017) (46)
GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge (2016) (43)
Analyzing the Effects of Delaying Aster Separation on Furrow Formation during Cytokinesis in the Caenorhabditis elegans Embryo (2009) (43)
Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation (2016) (42)
Large scale commercial fabrication of high quality graphene-based assays for biomolecule detection (2017) (41)
Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates (2017) (41)
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant (2013) (38)
The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C. (2019) (37)
Affinity purification of protein complexes in C. elegans. (2011) (37)
Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans (2015) (35)
Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases. (2014) (33)
A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores (2021) (32)
Cell structure and dynamics (2008) (30)
The ARP2/3 complex prevents excessive formin activity during cytokinesis (2019) (30)
[41] Purification of cytoskeletal proteins using peptide antibodies (1998) (29)
Closing the GAP: a role for a RhoA GAP in cytokinesis. (2003) (28)
The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix (2014) (27)
Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans (2015) (26)
Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation (2016) (25)
Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation (2016) (24)
Live confocal analysis with fluorescently labeled proteins. (1999) (24)
The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis (2019) (22)
Purification of cytoskeletal proteins using peptide antibodies. (1998) (21)
Purification and assay of a septin complex from Drosophila embryos. (1998) (20)
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome (2020) (20)
CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia (2017) (20)
A Non-canonical BRCT-Phosphopeptide Recognition Mechanism Underlies RhoA Activation in Cytokinesis (2020) (20)
CFI-400945 is not a selective cellular PLK4 inhibitor (2018) (20)
Centriole-independent mitotic spindle assembly relies on the PCNT–CDK5RAP2 pericentriolar matrix (2020) (19)
Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity (2019) (17)
Meiotic Double-Strand Breaks Uncover and Protect against Mitotic Errors in the C. elegans Germline (2013) (16)
Cell division. (2006) (14)
Deconstructing cytokinesis (2003) (13)
Studies on the centrosome and cytoplasmic organization in the early Drosophila embryo. (1991) (10)
A high-content imaging approach to profile C. elegans embryonic development (2019) (9)
Purification and reconstitution of Drosophila gamma-tubulin complexes. (2001) (6)
Septins in the Metazoan Model Systems Drosophila Melanogaster and Caenorhabditis Elegans (2008) (5)
Functional analysis of kinetochore assembly in C. elegans (2001) (4)
TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity (2021) (4)
The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly (2020) (4)
Employing the one-cell C. elegans embryo to study cell division processes. (2018) (4)
A toolkit for tissue-specific protein degradation in C. elegans (2017) (3)
Centriole Assembly Requires Both Centriolar (2004) (3)
Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans (2019) (3)
Methods in Cell Biology. Centrosome & Centriole. Preface. (2015) (2)
Ancestral Roles of the Fam20C Family of Secreted Protein Kinases Revealed by Functional Analysis in C. elegans (2018) (2)
2015 ASCB Annual Meeting abstracts (2015) (2)
Polo kinase phosphorylation determines C. elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation (2016) (1)
Abstract 4130: TRIM37 expression levels dictate susceptibility to centrosome removal, supporting Plk4 inhibition as a potential new strategy for targeting neuroblastoma (2018) (1)
Correction: Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation (doi:10.1242/dev.126615) (2018) (1)
Positive Feedback Between Contractile Ring Myosin and Ring-Directed Cortical Flow Drives Cytokinesis (2017) (1)
MEL-28/ELYS and CENP-C coordinately control outer kinetochore assembly and meiotic chromosome-microtubule interactions (2022) (1)
Figure 6, Mitotic kinetochores in the C. elegans embryo (2006) (0)
Figure 2, Nuclear envelope dynamics in the C. elegans embryo (2006) (0)
controls cancer-specific vulnerability to PLK4 inhibition. (2020) (0)
A role for Rab5 in structuring the endoplasmic reticulum (2007) (0)
1 Positive Feedback Between Contractile Ring Myosin and Ring-Directed Cortical Flow Drives 2 Cytokinesis 3 4 (2017) (0)
Figure 5, Mitotic kinetochores in the C. elegans embryo (2006) (0)
Eukaryotic cell division genes and their use in diagnostics as well as in the treatment of proliferative diseases (2001) (0)
The Minus End in Sight Review (2003) (0)
The Sterile Gene Collection: Filling the Gap in the Functional Genomic Analysis of Cell Biological Processes in C. elegans (2008) (0)
Recruitment of the (cid:103) -Tubulin Ring Complex to Drosophila Salt-stripped Centrosome Scaffolds (1998) (0)
Control of cell proliferation by memories of mitosis (2022) (0)
Table 2, Centrosome proteins (2006) (0)
How centrioles acquire the ability to reproduce (2017) (0)
Faculty Opinions recommendation of A positive feedback mechanism governs the polarity and motion of motile cilia. (2007) (0)
A Conserved RhoGAP Limits M-phase Contractility and Coordinates with Microtubule Asters to Restrict Active RhoA to the Cell Equator During Cytokinesis (2014) (0)
Five-Dimensional Microscopy using Widefield-Deconvolution: Practical Considerations and Biological Applications (1996) (0)
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant (2013) (0)
TPXL-1 mediates aster-based clearing of contractile ring proteins from the cell poles during cytokinesis. (2016) (0)
Table 4, Kinetochore proteins (2006) (0)
Polo-like kinase phosphorylation determines <italic>Caenorhabditis</italic> <italic>elegans</italic> centrosome size and density by biasing SPD-5 toward an assembly-competent conformation (2016) (0)
SAS-4 (dCPAP) TCP domain in complex with a Proline Rich Motif of Ana2 (dSTIL) of Drosophila Melanogaster (2013) (0)
Successive assembly of two proteins onto the centrosome coordinated with specific events during mitosis (1994) (0)
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition (2020) (0)
A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development. (2019) (0)
A Chemical Biology Approach to Centriole Function in Mammals Centrioles are microtubule-based organelles that direct the formation of centrosomes and cilia. Supernumerary centrosomes are linked to aneuploidy and are a common feature of human cancers (2015) (0)
Correction: Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans (2016) (0)
Analysis of microtubule binding by budding yeast kinetochores in vitro (2001) (0)
Cell Division * 3. Nuclear Envelope Structure and Dynamics Ce-man1 (lem-2) (2006) (0)
BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses (2023) (0)
JCB_201311015 1..11 (2014) (0)
PLK-1 tethered on BUB-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses (2022) (0)
Figure 3, Nuclear envelope dynamics in the C. elegans embryo (2006) (0)
Mechanism of spindle formation without centrosomes in mammalian cells (2017) (0)

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