Kari Alitalo

Q: What Schools Are Affiliated With Kari Alitalo

Kari Alitalo is affiliated with the following schools: Uppsala University, University of Tokyo, University of Eastern Finland, Keio University, University of Pittsburgh, University of Turku, Karolinska Institute, University of Helsinki

Why Is Kari Alitalo Influential?

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According to Wikipedia, Kari Kustaa Alitalo is a Finnish MD and a medical researcher. He is a foreign associated member of the National Academy of Sciences of the US. He became famous for his discoveries of several receptor tyrosine kinases and the first growth factor capable of inducing lymphangiogenesis: vascular endothelial growth factor C . In the years 1996–2007 he was Europe's second most cited author in the field of cell biology. Alitalo is currently serving as an Academy Professor for the Academy of Finland.

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Kari Alitalo's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia (2003) (2714)
Molecular regulation of angiogenesis and lymphangiogenesis (2007) (1891)
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis (2001) (1694)
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour (1983) (1404)
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. (1995) (1402)
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules (2015) (1384)
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins (2004) (1346)
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. (1997) (1291)
A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases. (1996) (1291)
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system (2009) (1267)
Lymphangiogenesis: Molecular Mechanisms and Future Promise (2010) (1215)
Lymphangiogenesis in development and human disease (2005) (1194)
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). (1998) (1185)
Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. (1999) (1036)
Clinical applications of angiogenic growth factors and their inhibitors (1999) (1032)
Vascular endothelial growth factor‐C‐mediated lymphangiogenesis promotes tumour metastasis (2001) (961)
Copy number variation and selection during reprogramming to pluripotency (2011) (932)
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. (1998) (932)
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism (2009) (822)
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3 (2001) (810)
Proteolytic processing regulates receptor specificity and activity of VEGF‐C (1997) (806)
Vascular endothelial growth factor B, a novel growth factor for endothelial cells. (1996) (800)
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation (2008) (795)
The lymphatic vasculature in disease (2011) (785)
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. (2002) (785)
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 (2001) (759)
Regulation of angiogenesis via vascular endothelial growth factor receptors. (2000) (754)
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. (1996) (731)
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. (1999) (717)
Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. (1994) (717)
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. (2009) (714)
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. (1996) (707)
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. (1983) (677)
Molecular mechanisms of lymphangiogenesis in health and disease. (2002) (675)
Metastasis: Lymphangiogenesis and cancer metastasis (2002) (674)
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. (2001) (674)
Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice (2001) (665)
Abnormal lymphatic vessel development in neuropilin 2 mutant mice. (2002) (647)
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. (2002) (642)
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema (2000) (636)
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor (2002) (631)
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. (2005) (595)
A model for gene therapy of human hereditary lymphedema (2001) (590)
Vascular endothelial growth factor C induces angiogenesis in vivo. (1998) (589)
Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development (1995) (570)
VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. (1999) (567)
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. (1998) (562)
VEGFs, receptors and angiogenesis. (1999) (561)
Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice (2007) (554)
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis (2004) (551)
Endothelial receptor tyrosine kinases involved in angiogenesis (1995) (539)
The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. (1995) (531)
Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. (1999) (513)
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. (2002) (510)
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. (2007) (505)
FGFR‐4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. (1991) (502)
VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. (1997) (498)
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia (1997) (493)
Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. (2000) (481)
The biology of vascular endothelial growth factors. (2005) (481)
Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma (2004) (473)
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. (2005) (447)
Interaction of endostatin with integrins implicated in angiogenesis. (2001) (446)
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts (2008) (441)
Gene transfer as a tool to induce therapeutic vascular growth (2003) (430)
VEGF-D Is the Strongest Angiogenic and Lymphangiogenic Effector Among VEGFs Delivered Into Skeletal Muscle via Adenoviruses (2003) (429)
VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. (2011) (429)
Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C* (1998) (421)
Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. (2004) (420)
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells (1983) (419)
Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. (2000) (416)
Vascular growth factors and lymphangiogenesis. (2002) (414)
Tie receptors: new modulators of angiogenic and lymphangiogenic responses (2001) (414)
Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. (2000) (413)
PDGF-C is a new protease-activated ligand for the PDGF α-receptor (2000) (411)
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth (2008) (409)
Signaling and Functions of Angiopoietin-1 in Vascular Protection (2006) (407)
Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. (2004) (405)
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. (2001) (400)
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. (2005) (394)
VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. (2003) (388)
Consensus guidelines for the use and interpretation of angiogenesis assays (2018) (370)
A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains (1992) (367)
PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor (2001) (363)
VEGF‐C and VEGF‐D expression in neuroendocrine cells and their receptor, VEGFR‐3, in fenestrated blood vessels in human tissues (2000) (361)
Molecular biology and pathology of lymphangiogenesis. (2008) (360)
Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. (2009) (357)
Oncogene amplification in tumor cells. (1986) (352)
Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. (2017) (352)
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. (2000) (350)
Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers* (1999) (350)
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14. (1993) (350)
Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors. (1998) (339)
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation (2007) (337)
Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. (1998) (324)
Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice (2001) (324)
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. (2013) (322)
Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3 (2010) (321)
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. (2001) (314)
Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1* (1999) (313)
Fibronectin is produced by human macrophages (1980) (313)
Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. (2001) (313)
Induction of a basement membrane glycoprotein in embryonic kidney: possible role of laminin in morphogenesis. (1980) (307)
Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors (2006) (307)
FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. (1992) (307)
Signaling via vascular endothelial growth factor receptors. (1999) (304)
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea (2002) (302)
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1 (2009) (298)
Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors (1999) (296)
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling (2011) (295)
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis (2011) (293)
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. (2010) (292)
Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis (1999) (292)
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr‐505 and down regulates its catalytic activity. (1992) (289)
Isolation of the pericellular matrix of human fibroblast cultures (1979) (287)
Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. (1999) (287)
Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites* (2003) (284)
Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis (2000) (283)
Comparative Evaluation of FGF-2–, VEGF-A–, and VEGF-C–Induced Angiogenesis, Lymphangiogenesis, Vascular Fenestrations, and Permeability (2004) (281)
Therapeutic targeting of the angiopoietin–TIE pathway (2017) (278)
Peripheral Blood Platelets Express VEGF-C and VEGF which Are Released during Platelet Activation (1998) (274)
Repression of cyclin D1: a novel function of MYC. (1994) (271)
Expression of vascular endothelial growth factor and placenta growth factor in human placenta. (1997) (264)
The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells (1993) (263)
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. (2005) (261)
Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. (2002) (256)
Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells (1999) (254)
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy (2013) (253)
Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells. (1999) (251)
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. (2005) (251)
Neural guidance molecules regulate vascular remodeling and vessel navigation. (2005) (251)
A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities* (1998) (251)
Genomic Organization of the Mouse and Human Genes for Vascular Endothelial Growth Factor B (VEGF-B) and Characterization of a Second Splice Isoform* (1996) (250)
Lymphangiogenic factors, mechanisms, and applications. (2014) (248)
Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries (2009) (246)
VEGF‐C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF‐7 tumors (2002) (245)
Development and plasticity of meningeal lymphatic vessels (2017) (244)
Therapeutic lymphangiogenesis with human recombinant VEGF‐C (2002) (243)
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. (2005) (240)
Lymphatic endothelium: a new frontier of metastasis research (2002) (240)
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. (2007) (238)
Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. (2000) (234)
An important role of lymphatic vessel activation in limiting acute inflammation. (2011) (229)
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2 (2005) (228)
Adenoviral Expression of Vascular Endothelial Growth Factor-C Induces Lymphangiogenesis in the Skin (2001) (228)
Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. (2002) (226)
The lymphatic vasculature: recent progress and paradigms. (2005) (226)
Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation (1989) (224)
Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation (2010) (224)
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. (1997) (222)
Identification of Tek/Tie2 Binding Partners (1999) (219)
Genomic Organization of Human and Mouse Genes for Vascular Endothelial Growth Factor C* (1997) (219)
Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. (2002) (217)
Vascular endothelial growth factor-C accelerates diabetic wound healing. (2006) (217)
Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. (1995) (216)
Large‐scale identification of genes implicated in kidney glomerulus development and function (2006) (215)
Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D (2003) (214)
Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors. (1998) (214)
The Specificity of Receptor Binding by Vascular Endothelial Growth Factor-D Is Different in Mouse and Man* (2001) (211)
Vascular endothelial growth factor signaling in development and disease (2018) (211)
Lymphatic System in Cardiovascular Medicine. (2016) (210)
Vascular endothelial growth factor (VEGF)‐C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity (1998) (205)
Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos (2008) (204)
Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells Are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis (2004) (200)
Endothelial destabilization by angiopoietin-2 via integrin β1 activation (2015) (199)
Identification of nuclear proteins encoded by viral and cellular myc oncogenes (1983) (196)
Vascular Endothelial Growth Factor-B–Deficient Mice Display an Atrial Conduction Defect (2001) (196)
Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors (2010) (194)
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. (2008) (194)
Nonvenous origin of dermal lymphatic vasculature. (2015) (191)
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting (2007) (191)
Serum vascular endothelial growth factor is often elevated in disseminated cancer. (1997) (190)
Role of lymphangiogenic factors in tumor metastasis. (2004) (189)
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts (2010) (188)
Current biology of VEGF-B and VEGF-C. (1999) (188)
CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation (2014) (188)
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. (2015) (186)
Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis (2012) (186)
Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. (1999) (182)
The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues (2002) (182)
Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent Mechanisms (2009) (181)
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. (1994) (180)
Adenoviral VEGF‐C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes (2002) (180)
The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis (2014) (178)
A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. (2013) (178)
Structural determinants of growth factor binding and specificity by VEGF receptor 2 (2010) (178)
PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. (2004) (175)
Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma. (1984) (175)
Vascular endothelial growth factor D ( VEGF-D ) is a ligand for the tyrosine kinases VEGF receptor 2 ( Flk 1 ) and VEGF receptor 3 ( Flt 4 ) (1998) (175)
BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. (1994) (174)
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation (2001) (173)
Signaling angiogenesis and lymphangiogenesis. (1998) (173)
Enhanced expression of TGF-beta and c-fos mRNAs in the growth plates of developing human long bones. (1988) (172)
Evidence of a leading role for VEGF in Bartonella henselae‐induced endothelial cell proliferations (2001) (170)
Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2 (2003) (167)
CKIα ablation highlights a critical role for p53 in invasiveness control (2011) (167)
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain (2006) (166)
Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects (2002) (165)
Fibroblast growth factor receptor‐4 shows novel features in genomic structure, ligand binding and signal transduction. (1992) (163)
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. (2014) (162)
Activation of Hypoxia-Inducible Factor-1 in Bacillary Angiomatosis: Evidence for a Role of Hypoxia-Inducible Factor-1 in Bacterial Infections (2005) (162)
VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. (2016) (161)
Endothelial-specific gene expression directed by the tie gene promoter in vivo. (1995) (159)
Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. (1996) (158)
Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. (2008) (157)
Tie1 controls angiopoietin function in vascular remodeling and inflammation. (2016) (156)
CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. (2010) (155)
VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis. (2000) (154)
The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis. (1994) (154)
c‐Myc induces cellular susceptibility to the cytotoxic action of TNF‐alpha. (1994) (153)
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. (2011) (152)
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours (2020) (151)
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response (1999) (151)
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation. (2006) (149)
Lymphangiogenesis and cancer metastasis. (2006) (148)
Vascular endothelial growth factors VEGF‐B and VEGF‐C (1997) (147)
Extracellular matrix proteins of human epidermal keratinocytes and feeder 3T3 cells (1982) (146)
Biological Basis of Therapeutic Lymphangiogenesis (2011) (146)
myc oncogenes: activation and amplification. (1987) (145)
Chromosomal Location, Exon Structure, and Vascular Expression Patterns of the Human PDGFC and PDGFD Genes (2001) (145)
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. (2016) (144)
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. (2011) (144)
Amniotic Fluid–Soluble Vascular Endothelial Growth Factor Receptor‐1 in Preeclampsia (2000) (143)
Etk/Bmx Transactivates Vascular Endothelial Growth Factor 2 and Recruits Phosphatidylinositol 3-Kinase to Mediate the Tumor Necrosis Factor-induced Angiogenic Pathway* (2003) (143)
Intravascular Adenovirus-Mediated VEGF-C Gene Transfer Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta (2000) (143)
Endostatin Associates with Lipid Rafts and Induces Reorganization of the Actin Cytoskeleton via Down-regulation of RhoA Activity* (2003) (142)
Extracellular matrix components synthesized by human amniotic epithelial cells in culture (1980) (142)
Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation (2010) (141)
Vascular Endothelial Growth Factor Enhances Cardiac Allograft Arteriosclerosis (2002) (141)
Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy (2008) (141)
VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption (2015) (141)
Lymphatic vessels regulate immune microenvironments in human and murine melanoma. (2016) (140)
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. (2010) (140)
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1 (2011) (139)
Receptor tyrosine kinase-mediated angiogenesis. (2013) (139)
Origins of Serum Semicarbazide-Sensitive Amine Oxidase (2004) (139)
Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema (2011) (139)
Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization. (1992) (138)
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart (2014) (136)
Molecular lymphangiogenesis: new players. (2005) (135)
Lymphatic Vessels as Targets of Tumor Therapy? (2001) (135)
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo. (2002) (134)
Vascular endothelial growth factor-B in physiology and disease. (2014) (133)
Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer. (2008) (133)
Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts (2010) (132)
Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice. (2007) (132)
Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29. (1983) (131)
Net‐targeted mutant mice develop a vascular phenotype and up‐regulate egr‐1 (2001) (131)
Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. (1997) (130)
VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy (2013) (130)
Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1. (1994) (129)
The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells. (1988) (129)
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. (2014) (128)
Vascular endothelial growth factor receptor-3. (1999) (128)
Angiopoietin‐regulated recruitment of vascular smooth muscle cells by endothelial‐derived heparin binding EGF‐like growth factor (2003) (127)
FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter. (1992) (127)
Stabilized HIF‐1α is superior to VEGF for angiogenesis in skeletal muscle via adeno‐associated virus gene transfer (2005) (126)
Lymphangiogenic growth factors, receptors and therapies (2003) (126)
Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis. (2007) (126)
The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. (1997) (123)
Proprotein convertases promote processing of VEGF‐D, a critical step for binding the angiogenic receptor VEGFR‐2 (2007) (123)
Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas. (1994) (122)
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase (1994) (122)
Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. (2012) (122)
Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkey. (2002) (121)
Induction of TNF‐sensitive cellular phenotype by c‐Myc involves p53 and impaired NF‐κB activation (1997) (120)
Overexpression of VEGF in Testis and Epididymis Causes Infertility in Transgenic Mice: Evidence for Nonendothelial Targets for VEGF (1998) (120)
Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma. (1999) (119)
Vegfc is required for vascular development and endoderm morphogenesis in zebrafish (2004) (119)
Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts. (1993) (119)
Fibronectin in the development of embryonic chick eye. (1979) (118)
The Drosophila VEGF receptor homolog is expressed in hemocytes (2001) (117)
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. (2011) (117)
KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. (2011) (117)
Modeling lymphangiogenesis in a three-dimensional culture system (2008) (117)
Alternative Forms of Max as Enhancers or Suppressors of Myc-Ras Cotransformation (1992) (116)
VEGFR3 does not sustain retinal angiogenesis without VEGFR2 (2015) (115)
Mouse models for studying angiogenesis and lymphangiogenesis in cancer (2013) (115)
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 (2020) (115)
Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage (2012) (114)
Pericellular matrix in malignant transformation. (1982) (114)
Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3. (2000) (113)
Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium (2008) (112)
Lymphangiogenesis guidance by paracrine and pericellular factors (2017) (112)
Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading (1995) (112)
The Prox1–Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors (2014) (111)
Localization of VEGF‐B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature (1999) (111)
Angiopoietin-1 Protects Against the Development of Cardiac Allograft Arteriosclerosis (2003) (111)
Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro. (2007) (111)
Developmental expression of Pim kinases suggests functions also outside of the hematopoietic system (2000) (111)
Diverse receptors for fibroblast growth factors. (1992) (110)
Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle (2009) (110)
Papillary intralymphatic angioendothelioma (PILA): a report of twelve cases of a distinctive vascular tumor with phenotypic features of lymphatic vessels. (1999) (109)
Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. (2012) (109)
In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis (2012) (109)
Viral Oncogene–Induced DNA Damage Response Is Activated in Kaposi Sarcoma Tumorigenesis (2007) (109)
Putative tyrosine kinases expressed in K-562 human leukemia cells. (1990) (107)
An Endostatin-derived Peptide Interacts with Integrins and Regulates Actin Cytoskeleton and Migration of Endothelial Cells* (2004) (107)
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development (2013) (107)
Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro (1995) (106)
Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis (2011) (105)
Biosynthesis of two subunits of type IV procollagen and of other basement membrane proteins by a human tumor cell line. (1980) (105)
Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively. (1996) (105)
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. (2008) (104)
Role of Ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter (1999) (103)
Dural lymphatics regulate clearance of extracellular tau from the CNS (2019) (103)
How do angiopoietins Tie in with vascular endothelial growth factors? (2010) (102)
Genesis and pathogenesis of lymphatic vessels (2003) (100)
Is angiopoietin-2 necessary for the initiation of tumor angiogenesis? (1998) (99)
Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival (2018) (97)
Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer (2011) (97)
State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. (2015) (97)
CCBE1 Enhances Lymphangiogenesis via ADAMTS3-Mediated VEGF-C Activation (2014) (97)
The cellular response to induction of the p21 c‐Ha‐ras oncoprotein includes stimulation of jun gene expression. (1989) (96)
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. (2011) (96)
Vascular Endothelial Growth Factor-C Stimulates the Migration and Proliferation of Kaposi’s Sarcoma Cells* (1999) (95)
Tie Endothelial Cell-specific Receptor Tyrosine Kinase Is Upregulated in the Vasculature of Arteriovenous Malformations (1996) (95)
Vascular endothelial growth factor‐C gene therapy restores lymphatic flow across incision wounds (2004) (95)
Specific Induction of tie1 Promoter by Disturbed Flow in Atherosclerosis-Prone Vascular Niches and Flow-Obstructing Pathologies (2004) (94)
Cardiac lymphatics in health and disease (2018) (94)
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions (2014) (94)
Lymphangiogenesis and Cancer (2004) (93)
VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection (2016) (93)
Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. (2016) (92)
ACUTE MYELOGENOUS LEUKAEMIA WITH C-MYC AMPLIFICATION AND DOUBLE MINUTE CHROMOSOMES (1985) (92)
VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling (2017) (91)
Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis (2014) (89)
Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis (2004) (89)
Extracellular matrix proteins characterize human tumor cell lines (1981) (89)
Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet (2014) (89)
Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. (2010) (89)
Expression of Growth Factors and Growth Factor Receptors in Capillary Hemangioblastoma (1996) (88)
Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia. (1999) (88)
Visual mapping by fiber-FISH. (1995) (88)
VEGF-C and aortic cardiomyocytes guide coronary artery stem development. (2014) (87)
Intravital imaging of intestinal lacteals unveils lipid drainage through contractility. (2015) (87)
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. (2006) (87)
VEGF-C-driven lymphatic drainage enables brain tumor immunosurveillance (2019) (87)
Role of myc amplification and overexpression in cell growth, differentiation and death. (1993) (86)
The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells. (1996) (86)
Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. (2010) (85)
Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium. (2002) (85)
Lymph Node Transfer and Perinodal Lymphatic Growth Factor Treatment for Lymphedema (2013) (85)
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue. (2003) (84)
Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis. (2005) (84)
Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis. (2002) (84)
VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors. (2008) (84)
Subcellular location of an abundant substrate (p36) for tyrosine-specific protein kinases. (1983) (84)
Avian VEGF-C: cloning, embryonic expression pattern and stimulation of the differentiation of VEGFR2-expressing endothelial cell precursors. (1998) (84)
Vascular endothelial growth factor-D expression in human atherosclerotic lesions. (2003) (84)
Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase (1989) (84)
Multiple Forms of Mouse Vascular Endothelial Growth Factor-D Are Generated by RNA Splicing and Proteolysis* (2001) (83)
Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells. (2001) (82)
Gene Transfers of Vascular Endothelial Growth Factor-A, Vascular Endothelial Growth Factor-B, Vascular Endothelial Growth Factor-C, and Vascular Endothelial Growth Factor-D Have No Effects on Atherosclerosis in Hypercholesterolemic Low-Density Lipoprotein-Receptor/Apolipoprotein B48-Deficient Mice (2005) (81)
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation (2013) (81)
Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines (1987) (81)
Molecular regulation of lymphangiogenesis and targets for tissue oedema. (2001) (81)
A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5. (1992) (80)
Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. (1994) (80)
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span (2021) (79)
VEGFR3 gene structure, regulatory region, and sequence polymorphisms. (2001) (79)
Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function (2003) (78)
Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium (2001) (77)
Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. (1997) (77)
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues. (2008) (76)
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. (2014) (76)
Amplification of cellular oncogenes in cancer cells. (1985) (76)
Prognostic value of tumour vascularity in metastatic melanoma and association of blood vessel density with vascular endothelial growth factor expression. (1999) (76)
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer (2021) (76)
Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages (2019) (76)
Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling (2019) (75)
A chimeric EGF‐R‐neu proto‐oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. (1989) (75)
Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development (2010) (75)
Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans (2015) (73)
Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer. (1985) (73)
Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels (2008) (72)
Consensus statement on the immunohistochemical detection of ocular lymphatic vessels. (2014) (71)
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells (2013) (71)
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. (2008) (70)
Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant. (1999) (70)
Induction of platelet‐derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines. (1987) (70)
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1 (2017) (70)
Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization (2017) (69)
Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells (1991) (69)
VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. (2008) (68)
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells (1985) (68)
Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells (1997) (66)
Basal lamina glycoproteins are produced by neuroblastoma cells (1980) (65)
Modulating metastasis by a lymphangiogenic switch in prostate cancer (2007) (65)
Gene transfer into rabbit arteries with adeno‐associated virus and adenovirus vectors (2004) (64)
Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene. (1986) (64)
Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro (2004) (64)
p130Cas Couples the Tyrosine Kinase Bmx/Etk with Regulation of the Actin Cytoskeleton and Cell Migration* (2003) (64)
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. (2005) (64)
The N-myc proto-oncogene and IGF-II growth factor mRNAs are expressed by distinct cells in human fetal kidney and brain (1989) (64)
Recessive primary congenital lymphoedema caused by a VEGFR3 mutation (2009) (63)
Early Lymph Vessel Development From Embryonic Stem Cells (2006) (63)
Anatomy and function of the vertebral column lymphatic network in mice (2019) (63)
Essential Roles for the Tec Family Kinases Tec and Btk in M-CSF Receptor Signaling Pathways That Regulate Macrophage Survival1 (2008) (62)
Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. (2009) (62)
AAV9-mediated VEGF-B gene transfer improves systolic function in progressive left ventricular hypertrophy. (2012) (62)
FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1α (2002) (61)
VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study (2015) (60)
Expression and prognostic value of transcription factor PROX1 in colorectal cancer (2011) (60)
Refined assignment of the infantile neuronal ceroid lipofuscinosis (INCL, CLN1) locus at 1p32: incorporation of linkage disequilibrium in multipoint analysis. (1993) (60)
Endothelial growth factor receptors in human fetal heart. (1999) (60)
A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos (2002) (60)
Insights into the Molecular Pathogenesis and Targeted Treatment of Lymphedema (2002) (59)
cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src). (1991) (59)
Vascular endothelial growth factor is bound in amniotic fluid and maternal serum. (1999) (59)
Biosynthesis of an unusual collagen type by human astrocytoma cells in vitro. (1983) (59)
An Alu variable polyA repeat polymorphism upstream of L-myc at 1p32. (1992) (58)
Structural and functional specificity of FGF receptors. (1993) (58)
Endostatin signaling and regulation of endothelial cell-matrix interactions. (2005) (57)
Dose effects of transfected c-Ha-rasVal 12 oncogene in transformed cell clones. (1987) (57)
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. (2010) (57)
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies (2002) (57)
FOXC 2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc 1 (2009) (56)
Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR‐75‐1 human breast cancer cells in vitro and in nude mice (1991) (56)
The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands (2013) (54)
The Angiogenic and Lymphangiogenic Factor Vascular Endothelial Growth Factor-D Exhibits a Paracrine Mode of Action in Cancer (2002) (54)
Roles of Prostaglandin E2–EP3/EP4 Receptor Signaling in the Enhancement of Lymphangiogenesis During Fibroblast Growth Factor-2–Induced Granulation Formation (2011) (54)
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase–FGFR4 complex (2010) (54)
The bloody fate of endothelial stem cells. (2003) (54)
Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors. (2000) (54)
Oral Imatinib Mesylate (STI571/Gleevec) Improves the Efficacy of Local Intravascular Vascular Endothelial Growth Factor-C Gene Transfer in Reducing Neointimal Growth in Hypercholesterolemic Rabbits (2004) (54)
Perspectives on lymphangiogenesis and angiogenesis in cancer (2011) (54)
MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. (2015) (54)
A molecular and genetic analysis of renalglomerular capillary development (2004) (53)
Vascular endothelial growth factor-C: a growth factor for lymphatic and blood vascular endothelial cells. (1998) (53)
Double target for tumor mass destruction. (2003) (53)
Pulmonary Lymphangiectasia Resulting From Vascular Endothelial Growth Factor-C Overexpression During a Critical Period (2014) (53)
Expression of the myc proto-oncogenes in developing human fetal brain. (1990) (52)
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β (2014) (52)
Basal lamina glycoproteins laminin and type IV collagen are assembled into a fine-fibered matrix in cultures of a teratocarcinoma-derived endodermal cell line. (1982) (52)
PDGF-A, -C, and -D but not PDGF-B Increase TGF-&bgr;1 and Chronic Rejection in Rat Cardiac Allografts (2009) (52)
Activation of protein kinase C increases phosphorylation of the L-myc trans-activator domain at a GSK-3 target site. (1992) (52)
Angiopoietin-Like 4 Mediates PPAR Delta Effect on Lipoprotein Lipase-Dependent Fatty Acid Uptake but Not on Beta-Oxidation in Myotubes (2012) (52)
Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis (2010) (52)
Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis (2013) (51)
Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. (2010) (51)
Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis. (1996) (51)
Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis. (2002) (50)
The VEGF Family, the Inside Story (2007) (49)
Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF‐7 breast‐cancer cells (1992) (49)
The yin, the yang, and the angiopoietin-1. (2011) (49)
FIBRONECTIN AND THE PERICELLULAR MATRIX OF NORMAL AND TRANSFORMED ADHERENT CELLS * (1978) (49)
Type III procollagen is the major collageneous component produced by a continuous rhabdomyosarcoma cell line (1979) (49)
BCL 2 Overexpression Associated With Chromosomal Amplification in Diffuse Large B-Cell Lymphoma (1997) (48)
Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice. (2009) (48)
Immunodetection and quantification of vascular endothelial growth factor receptor‐3 in human malignant tumor tissues (2004) (48)
Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema (2006) (47)
PHD2 regulates arteriogenic macrophages through TIE2 signalling (2013) (47)
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation (2016) (47)
The p36 substrate of tyrosine‐specific protein kinases co‐localizes with non‐erythrocyte alpha‐spectrin antigen, p230, in surface lamina of cultured fibroblasts. (1983) (47)
Essential Role of the Coxsackie - and Adenovirus Receptor (CAR) in Development of the Lymphatic System in Mice (2012) (47)
Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells. (1990) (47)
Chimeric VEGF-ENZ7/PlGF Promotes Angiogenesis Via VEGFR-2 Without Significant Enhancement of Vascular Permeability and Inflammation (2006) (47)
Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection (2013) (46)
Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice (2015) (46)
Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature (2010) (46)
Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity (2010) (45)
Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50α (2009) (45)
[Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance]. (2014) (45)
Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns* (2006) (45)
Mechanically stretched chromosomes as targets for high-resolution FISH mapping. (1995) (45)
Vascular endothelial growth factor receptor 3 in hypoxia‐induced vascular development (2004) (44)
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies. (2021) (44)
Enhanced expression of transforming growth factor beta during megakaryoblastic differentiation of K562 leukemia cells. (1988) (44)
Biosynthesis of type V procollagen by A204, a human rhabdomyosarcoma cell line. (1982) (43)
A molecular and genetic analysis of renal glomerular capillary development (1997) (42)
Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII (2016) (42)
Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-CΔNΔC- and VEGF-A-induced angiogenesis in vitro (2003) (42)
Structural analysis of vascular endothelial growth factor receptor‐2/ligand complexes by small‐angle X‐ray solution scattering (2011) (41)
Role of synectin in lymphatic development in zebrafish and frogs. (2010) (41)
Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation (2020) (41)
BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias (1996) (40)
Androgen and fibroblast growth factor (FGF) regulation of FGF receptors in S115 mouse mammary tumor cells. (1995) (40)
Amplification of ornithine decarboxylase gene in response to polyamine deprivation in Chinese hamster ovary cells. (1985) (39)
The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner (2000) (39)
Distinct Architecture of Lymphatic Vessels Induced by Chimeric Vascular Endothelial Growth Factor-C/Vascular Endothelial Growth Factor Heparin-Binding Domain Fusion Proteins (2007) (39)
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms (2018) (39)
Blocking Fibroblast Growth Factor Receptor Signaling Inhibits Tumor Growth, Lymphangiogenesis, and Metastasis (2012) (38)
Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain. (2015) (38)
c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts (1990) (37)
Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways. (2013) (37)
Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. (2012) (36)
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. (2010) (36)
VEGF-C promotes the development of lymphatics in bone and bone loss (2018) (36)
VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy (2018) (36)
Lymphatic and Immune Cell Cross-Talk Regulates Cardiac Recovery After Experimental Myocardial Infarction (2020) (36)
Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. (2004) (36)
An avian model for studies of embryonic lymphangiogenesis. (2000) (36)
Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA. (2004) (36)
VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration. (2020) (35)
Common Protective and Diverse Smooth Muscle Cell Effects of AAV-Mediated Angiopoietin-1 and -2 Expression in Rat Cardiac Allograft Vasculopathy (2006) (35)
Association of a 85-kDa Serine Kinase with Activated Fibroblast Growth Factor Receptor-4 (*) (1996) (35)
Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia. (2006) (35)
Deposition of Basement Membrane Proteins in Attachment and Neurite Formation of Cultured Murine C‐1300 Neuroblastoma Cells (1982) (35)
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. (2012) (35)
Basal lamina components in experimentally induced skin blisters. (1981) (34)
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 (2017) (34)
Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice (2014) (34)
PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma (2016) (34)
Loss of Bmx Nonreceptor Tyrosine Kinase Prevents Pressure Overload–Induced Cardiac Hypertrophy (2008) (34)
Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice (2016) (34)
The myc proteins are not associated with chromatin in mitotic cells. (1984) (33)
Angiopoietin‐2 Inhibition Prevents Transplant Ischemia‐Reperfusion Injury and Chronic Rejection in Rat Cardiac Allografts (2014) (33)
Fibroblast Growth Factor-Mediated Growth Regulation and Receptor Expression in Embryonal Carcinoma and Embryonic Stem Cells and Human Germ Cell Tumors (1993) (33)
Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization. (2013) (33)
Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. (2003) (33)
Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis (2017) (33)
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene (1989) (33)
Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo (2011) (32)
Max activity is affected by phosphorylation at two NH2-terminal sites. (1994) (32)
Growth factor therapy and lymph node graft for lymphedema. (2015) (32)
Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants. (2006) (32)
Production of both interstitial and basement membrane procollagens by fibroblastic WI-38 cells from human embryonic lung. (1980) (32)
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish (2013) (32)
Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85. (1994) (31)
HIF‐1α and HIF‐2α induce angiogenesis and improve muscle energy recovery (2014) (31)
Expression of FGFR-4 mRNA in developing mouse tissues. (1992) (31)
Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance. (2014) (31)
Myc protein: partners and antagonists. (1994) (30)
Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription (1986) (30)
Loss of different pericellular matrix components of rat cells transformed with a T-class ts mutant of Rous sarcoma virus. (1982) (30)
Ischemia–Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts (2016) (30)
The Tyrosine Kinase BMX Is an Essential Mediator of Inflammatory Arthritis in a Kinase-Independent Manner (2011) (30)
Posttranslational modifications in the biosynthesis of type IV collagen by a human tumor cell line. (1981) (30)
Fibronectin and procollagen produced by a clonal line of Schwann cells (1979) (28)
The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. (1993) (28)
Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses (2012) (28)
TCR/CD3-triggering causes increased activity of the p50csk tyrosine kinase and engagement of its SH2 domain. (1994) (28)
A fusion protein formed by L‐myc and a novel gene in SCLC. (1991) (28)
Rapid phosphorylation of the L‐myc protein induced by phorbol ester tumor promoters and serum. (1989) (28)
Lymphatic Vessels in Tumor Dissemination versus Immunotherapy (2020) (28)
KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D (2019) (28)
Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis (2016) (27)
Phase 1 LymfactinⓇ Study: Short-term Safety of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema. (2020) (27)
Critical requirement of VEGF-C in transition to fetal erythropoiesis. (2016) (27)
Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling (2015) (26)
Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis (2020) (26)
Endothelial Tie Receptor Antigen in Maternal and Cord Blood of Healthy and Preeclamptic Subjects (1998) (26)
Enhanced bFGF gene expression in response to transforming growth factor-beta stimulation of AKR-2B cells. (1993) (25)
The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features. (2014) (25)
FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations (1993) (25)
Identification of YAC clones for human chromosome 1p32 and physical mapping of the infantile neuronal ceroid lipofuscinosis (INCL) locus. (1995) (25)
Immediate early gene responses of NIH 3T3 fibroblasts and NMuMG epithelial cells to TGF beta-1. (1991) (24)
Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines (1998) (24)
Increased Interstitial Protein Because of Impaired Lymph Drainage Does Not Induce Fibrosis and Inflammation in Lymphedema (2013) (24)
Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury (2019) (24)
VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche. (2020) (23)
Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi (2020) (23)
[Endothelial growth factor and growth factor receptor genes]. (1996) (23)
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models (2020) (23)
VEGFR-1 and -2 Regulate Inflammation, Myocardial Angiogenesis, and Arteriosclerosis in Chronically Rejecting Cardiac Allografts (2007) (23)
Plasmid pLTRpoly: a versatile high-efficiency mammalian expression vector. (1992) (23)
Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1 (2015) (23)
Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification. (1987) (22)
SnapShot: Angiopoietins and Their Functions (2017) (22)
Oncogene expression in small‐cell lung cancer cell lines and a testicular germ‐cell tumor: Activation of the N‐myc gene and decreased RB mRNA (1989) (22)
Induced Pluripotent Stem Cell Clones Reprogrammed via Recombinant Adeno-Associated Virus-Mediated Transduction Contain Integrated Vector Sequences (2012) (21)
Deposition of an intermediate form of procollagen type III (pN‐collagen) into fibrils in the matrix of amniotic epithelial cells. (1982) (21)
Regulation of collagen post-translational modification in transformed human and chick-embryo cells. (1981) (21)
Effects of Zn2+ ions on protein phosphorylation in epithelial cell membranes (1983) (20)
Characterization of ANGPT2 mutations associated with primary lymphedema (2020) (20)
Activation of an EGFR/neu chimeric receptor: early intracellular signals and cell proliferation responses. (1989) (20)
PROX1 is a transcriptional regulator of MMP14 (2018) (20)
Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS (2020) (20)
Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations (2012) (20)
Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice (2011) (20)
The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. (1995) (20)
Cell transformation by c‐Ha‐rasVal12 oncogene is accompanied by a decrease in histone H1° and an increase in nucleosomal repeat length (1995) (20)
The effect of platelet-derived growth factor ligands in rat cardiac allograft vasculopathy and fibrosis. (2006) (19)
Localization of the fibroblast growth factor receptor‐4 gene to chromosome region 5q33‐qter (1992) (19)
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research (2022) (19)
Growth factors regulating lymphatic vessels. (2000) (19)
Genetic Variants of VEGFA and FLT4 Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib. (2018) (19)
The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25. (1993) (19)
Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer (1991) (19)
Pericellular matrix and cell surface glycoproteins of virus-transformed mouse epithelial cells. (1982) (18)
Amplification and rearrangement of L-myc in human small-cell lung cancer. (1992) (18)
Donor Heart Treatment With COMP‐Ang1 Limits Ischemia‐Reperfusion Injury and Rejection of Cardiac Allografts (2015) (18)
VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis (2017) (18)
Molecular pathways for lymphangiogenesis and their role in human disease. (2007) (18)
Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells. (1993) (18)
PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1. (2012) (17)
Expression of the c‐Ha‐ras and neu oncogenes in DMBA‐induced, anti‐estrogen‐treated rat mammary tumors (1988) (17)
Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant (2021) (17)
Short and Long-Term Effects of hVEGF-A165 in Cre-Activated Transgenic Mice (2006) (16)
The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (1992) (16)
Mapping of amplified c-myb oncogene, sister chromatid exchanges, and karyotypic analysis of the COLO 205 colon carcinoma cell line. (1985) (16)
Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines (1985) (16)
Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. (2017) (16)
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries (2005) (16)
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine (2021) (16)
uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis (2018) (16)
Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits. (2018) (16)
Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid? (2015) (16)
Cardiomyocyte-targeted HIF-1alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat. (2010) (15)
Growth factors controlling angiogenesis and lymphangiogenesis. (2002) (15)
Antiangiogenic gene therapy with soluble VEGF‐receptors ‐1, ‐2 and ‐3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma (2012) (15)
c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors (1999) (15)
Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy (2016) (15)
Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein (2007) (14)
Distinct roles of the meningeal layers in CNS autoimmunity (2022) (14)
Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells. (1990) (14)
Analysis of patients with craniosynostosis syndromes for a pro246Arg mutation of FGFR4. (1998) (14)
Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. (1997) (14)
Damage and repair induced by bleomycin in the domain of human amplified MYC oncogenes. (1990) (14)
Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. (2003) (14)
Novel Human FGF Receptors with Distinct Expression Patterns (1991) (14)
Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line. (1989) (13)
Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium. (2020) (13)
Lymphangiogenesis in development and disease. (2007) (13)
Age-Dependent Remarkable Regenerative Potential of the Dentate Gyrus Provided by Intrinsic Stem Cells (2020) (13)
VEGFR 3 Modulates Vascular Permeability by Controlling VEGF / VEGFR 2 Signaling (2017) (13)
Reorganization of plasma membrane-associated 36 000 dalton protein upon drug-induced redistribution of cytokeratin. (1985) (12)
Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis (2015) (12)
Expression of R-spondin1 in ApcMin/+ Mice Reduces Growth of Intestinal Adenomas by Altering Wnt and TGFB Signaling. (2020) (12)
Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells. (2018) (12)
Endo- and ectocervical human uterine epithelial cells distinguished by fibronectin production and keratinization in culture. (1982) (12)
Molecular mechanisms of lymphangiogenesis. (2002) (12)
Activation of c-ras oncogenes by mutations and amplification. (1986) (12)
Complex intrachromosomal rearrangement in the process of amplification of the L-myc gene in small-cell lung cancer (1992) (12)
Preclinical safety, toxicology, and biodistribution study of adenoviral gene therapy with sVEGFR-2 and sVEGFR-3 combined with chemotherapy for ovarian cancer. (2013) (11)
Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity (2011) (11)
Fibroblast growth factor-mediated growth regulation and receptor expression in embryonal carcinoma and embryonic stem cells and human germ cell tumours. (1993) (11)
Expression of a rlf/L-myc minigene inhibits differentiation of embryonic stem cells and embroid body formation. (1994) (11)
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance (2022) (10)
VEGF-B binds to VEGFR-1 and regulates plasminogen activator activity in endothelial cells (1998) (10)
Regulation by EGF is maintained in an overexpressed chimeric EGFR/neu receptor tyrosine kinase (1990) (10)
FLT 4 Receptor Tyrosine Kinase Contains Seven Immunoglobulin-like Loops and Is Expressed in Multiple Human Tissues and Cell Lines 1 (2006) (10)
Determination of sequences responsible for the differential regulation of Myc function by delta Max and Max. (1995) (10)
Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors1 (2016) (10)
Improved endothelialization of small-diameter ePTFE vascular grafts through growth factor therapy (2018) (9)
Proto-oncogene amplification: role in tumour progression. (1986) (9)
Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4. (2000) (9)
PROX1 is involved in progression of rectal neuroendocrine tumors, NETs (2015) (9)
Reply to Kerbel et al.: EPCs are again claimed to be essential in yet other models despite the irreproducibility of the original experiments introducing them (2008) (9)
High baseline Tie1 level predicts poor survival in metastatic breast cancer (2019) (9)
Downregulation of the early genomic growth factor response in neu oncogene-transformed cells. (1990) (9)
Clear-cell sarcoma of tendons and aponeuroses. Report of two cases. (1977) (9)
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene ( c-mnc ) in malignant neuroendocrine cells from a human colon carcinoma ( double minute chromosomes / chromosome aberrations / retroviruses / tumorigenesis ) (8)
The TIE Receptor Family (2015) (8)
VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury (2021) (8)
Functional analysis of FLT4 mutations associated with Nonne-Milroy lymphedema. (2009) (8)
Rearrangement and co-amplification of L-myc and rlf in primary lung cancer. (1992) (8)
Ex vivo intracoronary gene transfer of adeno‐associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants (2013) (7)
UV damage and repair in the domain of the human c-myc oncogene. (1991) (7)
RFLPs in the fibroblast growth factor receptor-4 locus (FGFR4) in 5q33-qter. (1991) (7)
Tumour markers and oncogenes in lung cancer. (1991) (7)
PROX 1 and beta-catenin are prognostic markers in pancreatic ductal adenocarcinoma (6)
Five FGF receptors with distinct expression patterns. (1992) (6)
The methylation pattern of normal and truncated amplified human c-myc oncogenes. (1989) (6)
Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera. (1989) (6)
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression (2022) (6)
Matrix reloaded to circulation hits the tumor target. (2003) (6)
Transforming growth factor‐β does not alter interleukin‐1 expression in cultured human macrophages (1989) (6)
Functional MRI Measurements to Predict Early Adenoviral Gene Therapy Response in Ovarian Cancer Mouse Model (2013) (6)
A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein. (1992) (6)
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor‐induced signals for gene activation (1991) (6)
Myc amplification: regulation of myc function. (1993) (5)
European Perspectives in Cardiology (2013) (5)
Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro. (1998) (5)
Oral presentation 31Podoplanin-induced platelet aggregation mediates separation of blood and lymphatic vessels (2006) (5)
VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study (2015) (5)
VEGFR-3 mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels (2005) (5)
Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart (2017) (5)
[The clinical significance of oncogenes]. (1988) (5)
Distribution of the 36 000 dalton tyrosine protein kinase substrate in drug and epidermal growth factor-treated epithelial cells. (1984) (5)
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas (2021) (5)
Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. (2018) (5)
Binding of a nuclear factor to the upstream region of the c-myc gene. (1991) (5)
Inside bloody lymphatics. (2010) (5)
Midkine and Melanoma Metastasis: A Malevolent Mix. (2017) (5)
Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation (2020) (5)
Repression of cyclin D1: a novel function of MYC (1994) (5)
The biology of vascular endothelial growth factors: [review] (2005) (5)
White adipose tissue coloring by intermittent fasting (2017) (5)
VEGF-D: a modifier of embryonic lymphangiogenesis. (2008) (5)
Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation (2020) (4)
Phase 1 Lymfactin® Study: 24-month Efficacy and Safety Results of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema. (2022) (4)
Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase. (1991) (4)
Tyrosine kinases in control of cell growth and transformation. (1986) (4)
Vascular endothelial growth factors and receptors involved in angiogenesis and lymphangiogenesis (1997) (4)
Yet another function for hepatocyte growth factor (2006) (4)
Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice (2006) (4)
Periadventitial angiopoietin 1 gene transfer induces angiogenesis in rabbit carotid arteries (2005) (4)
Systemic Blockade of ACVR 2 B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury (4)
On the relationship of LDL and VEGFR1: not just a family affair (2007) (4)
Transformation of cultured epithelial cells by ethylnitrosourea. Altered expression of type I procollagen chains. (1984) (4)
A radical view of pathological vasculature. (2012) (3)
Lysophosphatidylcholine in phospholipase A2-modified LDL triggers secretion of angiopoietin 2. (2021) (3)
Regulation of proline 3-hydroxylation and prolyl 3-hydroxylase and 4-hydroxylase activities in transformed cells. (1982) (3)
MACROPHAGE SKEWING BY PHD 2 HAPLODEFICIENCY PREVENTS ISCHEMIA BY INDUCING ARTERIOGENESIS (2012) (3)
A sub‐set of immediate early mRNAs induced by tumor necrosis factor‐α during cellular cytotoxic and non‐cytotoxic responses (1993) (3)
Regulation by TGFβ of Genes Involved in Growth Control: Interleukin‐6 a (1990) (3)
Genes protecting from cancer. (1990) (3)
Synthetic peptides in biology and medicine : proceedings of the Labsystems Research Symposium on Synthetic Peptides in Biology and Medicine held in Hämeenlinna, Finland, on June 6-8, 1985 (1985) (3)
Recombinant systems in protein expression : proceedings of the Labsystems Research Symposium II on Recombinant Systems in Protein Expression, Imatra, Finland, 23-26 July 1989 (1990) (3)
Molecular Targeting of Lymphangiogenesis and Tumor Metastasis (2009) (3)
myc, max, and a novel rlf-L-myc fusion protein in small-cell lung cancer. (1991) (3)
inflammation An important role of lymphatic vessel activation in limiting acute (2011) (3)
Cancer biology, second edition: by Raymond W. Ruddon, Oxford University Press, 1987. £25.00 (xiii + 530 pages) ISBN 0 19 504384 (1988) (3)
The VEGF Family (2007) (3)
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours (2020) (3)
Genetic Engineering of Lymphangiogenesis in Skin Does Not Affect Blood Pressure in Mouse Models of Salt-Sensitive Hypertension (2022) (3)
Fighting vessel dysmorphia to improve glioma chemotherapy (2017) (2)
Expression Patterns of VEGF Receptors in Healthy Human and Monkey Retina: Involvement of VEGFs in Physiology? (2002) (2)
Plasmin activates VEGF-C and VEGF-D (2004) (2)
Author response: Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII (2016) (2)
endothelial growth factor Notch restricts lymphatic vessel sprouting induced by vascular (2011) (2)
29: Role of Vascular Endothelial Growth Factor-C in Experimental Obliterative Airway Disease (2008) (2)
p130 Cas Couples the Tyrosine Kinase Bmx/Etk with Regulation of the Actin Cytoskeleton and Cell Migration* (2003) (2)
Tumor and Stem Cell Biology CXCR 4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche (2010) (2)
100 POSTER Targeting tie-1 inhibits the growth of tumor xenografts as a monotherapy and has increased activity in combination with a VEGF inhibitor (2006) (2)
VEGFR3 gene structure, regulatory region, and sequence polymorphisms (2001) (2)
Angiopoietins and Tie Receptors (2008) (2)
Recombinant vascular endothelial cell growth factor D (1997) (2)
PO6-160 GENE TRANSFERS OF VEGF-GENE FAMILY HAVE NO EFFECT ON ATHEROSCLEROSIS IN LDLR/APOB48-DEFICIENT MICE (2007) (2)
Mechanism of T cell proliferation in vivo: analysis of IL-2 receptor expression and activation of c-myc and c-myb oncogenes during lymphatic regeneration. (1989) (2)
Combination of VEGF-C gene transfer and treatment with the PDGF receptor kinase inhibitor STI571 leads to persistent reduction in neointima formation in balloon-denunded rabbit aorta (2002) (2)
Common anti-inflammatory and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allografts (2005) (2)
Basic Science for Clinicians Biological Basis of Therapeutic Lymphangiogenesis (2011) (1)
454: Targeting Lymphatic Vessel CCL21 Production by VEGFR-3 Inhibition Prevents Cardiac Allograft Rejection and Arteriosclerosis (2009) (1)
THE ROLE OF MENINGEAL LYMPHATICS IN ALZHEIMER-RELATED AMYLOID PATHOLOGY (2018) (1)
Lymphangiogenesis in melanoma, squamous cell carcinoma and breast carcinoma (2001) (1)
Evidence for p15 cleavage site in myc‐specific proteins of avian MC29 and OK10 viruses (1985) (1)
Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation (2020) (1)
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells (2013) (1)
Fifteen years of molecular lymphangiogenesis - an interview with Kari Alitalo by Tatiana Petrova. (2011) (1)
Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury (2022) (1)
State-ofthe-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization (2015) (1)
Lymphangiogenesis in Health and Disease – An Overview (2009) (1)
ANTI-INFLAMMATORY EFFECTS OF AAV-MEDIATED ANGIOPOIETIN-1 AND –2 EXPRESSION IN RAT CARDIAC ALLOGRAFTS (2004) (1)
Author response: VEGF-C promotes the development of lymphatics in bone and bone loss (2018) (1)
Detection, Isolation and Culture of Lymphatic Endothelial Cells (2004) (1)
Abstract 731: Sorafenib Induces Cardiotoxicity via Damage to Cardiac Endothelial Cells (2019) (1)
Lymphatic-to-blood vessel transdifferentiation in zebrafish (2022) (1)
Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart. (2021) (1)
Improved endothelialization of small-diameter ePTFE grafts through growth factor therapy. (2018) (1)
VEGF-A and PDGF-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels (2017) (1)
CHAPTER 263 – Vascular Endothelial Growth Factors and their Receptors in Vasculogenesis, Angiogenesis, and Lymphangiogenesis (2003) (1)
2SY04-4 VEGF-D: A molecular regulator of lymphangiogenesis (2003) (1)
Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to (2010) (1)
Oncogene Amplification (2020) (1)
The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium (2023) (1)
Abstract LB-422: Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis (2011) (1)
Acknowledgment to Reviewers (2019) (1)
[Altering genes by homologous recombination--the newest weapon of basic sciences]. (1990) (1)
Growth factors and lymphangiogenesis (2006) (1)
Scientific Statement From the American Heart Association State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A (2015) (1)
Anatomy of the vertebral column lymphatic network in mice (2019) (1)
PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma (2020) (1)
Altered immune responses in mice without initial dermal lymphatics (2009) (1)
Nucleotide sequence of the v-myc oncogene of avian retrovirus MC 29 ( leukemia / carcinoma / myelocytomatosis / tumor virus / DNA-binding protein ) (2003) (1)
[Connective tissue and the malignant cell]. (1980) (0)
78 Targeting Multiple Endothelial Growth Factor Pathways (2012) (0)
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 (2017) (0)
Quantification of amplified oncogenes in tumour cell lines by a nucleic acid sandwich hybridization technique (1987) (0)
CRYSTAL STRUCTURE OF VEGF-C IN COMPLEX WITH DOMAINS 2 AND 3 OF VEGFR2 IN A TETRAGONAL CRYSTAL FORM (2010) (0)
Results Ang 2 and Tie 2 Immunoreactivity Is Induced in Capillaries and Postcapillary Venules of Cardiac Allografts (2003) (0)
Abstracts of the 17th Meeting of the European Study Group for Cell Proliferation 13–15 September 1990, ESPOO, Finland (1991) (0)
Aha Scientific Statement 1. in Vitro Assays State-of-the-art Methods for Evaluation of Angiogenesis and Tissue Vascularization a Scientific Statement from the American Heart Association on Behalf of the American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular (2015) (0)
V ascular endothelial growth factor-D expression in human atherosclerotic lesions (2003) (0)
Normal Vasculature Review of angiogenesis, the process Properties of normal vasculature (2013) (0)
[From oncogenes to molecular biology of cancer and prevention of angiogenesis]. (1998) (0)
PROTEOLYTIC ACTIVATION OF VEGF-C AND VEGF-D (2004) (0)
Therapeutic potential of endothelial growth factors and receptors (2013) (0)
Crystal structure of Tie1 Fibronectin-like domain 3 (2017) (0)
[The Nobel Prize in Medicine for the discovery of cell oncogenes]. (1989) (0)
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms (2018) (0)
[Neoplasms under control with the help of vascular treatment?]. (2000) (0)
THE DISTRIBUTION OF HHV-8 LATENTLY INFECTED CELLS IN ALL STAGES OF KAPOSI'S SARCOMA (1999) (0)
PO9-252 PERSISTENT PDGF -A, -C, -D TRANSGENE EXPRESSION ACCELERATES DEVELOPMENT OF CARDIAC ALLOGRAFT VASCULOPATHY AND FIBROSIS BUT NOT -B INDUCES MYOCARDIAL ANGIOGENESIS (2007) (0)
[Nuclear pathway of interferons]. (1993) (0)
Vascular Endothelial Growth Factor C Promotes Tumor Lymphangiogenesis and Intralymphatic Tumor Growth 1 (2001) (0)
High baseline Tie1 level predicts poor survival in metastatic breast cancer (2019) (0)
Visual analysis of DNA rearrangement in small cell lung cancer (SCLC) by fish to extended DNA (1995) (0)
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models (2023) (0)
Flt4 (VEGFR-3) as a target for cancer presentation and anti-cancer-treatment (2002) (0)
Using an in vivo reporter for lymphan a new subset of melanomas that ind metastatic niches , and identifies (2017) (0)
lymphatic endothelial cells ex vivo and in vitro Transcriptomal comparison of human dermal (2015) (0)
- Flt4: Flt4 receptor PTK (vertebrates) (1995) (0)
VEGF-C induces collateral formation in ischaemic porcine heart model (2004) (0)
334: VEGFR-3 signalling mediates lymphangiogenesis and alloimune reactions in cardiac allografts (2006) (0)
The lymphatic ring assay: a new in vitro model of lymphangiogenesis (2006) (0)
[Regulation of melanoma growth]. (1992) (0)
EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory (2023) (0)
Thanks to Reviewers (2014) (0)
Intracoronary Treatment with VEGF-C/D Inhibitor Enhances Cardiac Allograft Survival and Prevents Chronic Rejection by Regulating Lymphatic Endothelial Cell Activation (2013) (0)
VEGF-C adenovirus gene transfer reduces intima formation in rabbits (2000) (0)
Tyrosine Kinase Induces thefos/jun Transcription Factor Complex, the Glucose Transporter, and Ornithine Decarboxylase (2002) (0)
[Complex mechanics of tumor-necrosis-factor-induced cell death]. (1992) (0)
Abstract 4836: In vitro drug sensitivity testing along with full genome and transcriptome sequencing and phosphoproteomics: Comprehensive “next-generation” molecular oncology portrait of a sarcoma for facilitating treatment decisions (2011) (0)
Results Effects of Western Diet on Blood Lipid Levels in Mice With Dysfunctional Lymphatic Vessels (0)
417: Constitutively Expressed Hypoxia-Inducible Factor-1α Prevents the Development of Cardiac Allograft Vasculopathy in the Rat (2008) (0)
Transgenic Overexpression of Cardiac-Specific Vascular Endothelial Growth Factor B Exacerbates Ischemia Reperfusion Injury in Rat Cardiac Grafts.: Abstract# C1688 (2014) (0)
Prox1 transcription factor regulates satellite cell and skeletal muscle fiber phenotype and function (2015) (0)
Mapping of PAI-1 to a region of abnormalities of chromosome 7 in cancer (1987) (0)
VEGFR-3 in primary lymphedema (2001) (0)
Therapeutic Insights to Lymphangiogenic Growth Factors (2015) (0)
Expression Of VEGFR3, VEGF-C And Other Lymphangiogenic Markers During The Development Of The Human Choroid (2011) (0)
P-GLYCOPROTEIN EXPRESSION CORRELATES WITH CHRONIC CYCLOSPORIN NEPHROTOXICITY AND INDEPENDENTLY WITH PHARMACOKINETIC INTERACTION OF CYCLOSPORIN AND SIROLIMUS (2006) (0)
Vascular Endothelial Growth Factor C (VEGF-C) Gene Therapy Attenuates Postoperative Lymphedema by Regenerating Collective Lymphatic Vessels (2006) (0)
Stimulation of transmural capillary endothelialization of small-diameter synthetic vascular grafts through local overexpression of a novel recombinant VEGFR2-ligand VEGF-A109 (2012) (0)
Crystal structure of VEGFR-3 extracellular domains D4-5 (2013) (0)
From technologies to scientific issues (1987) (0)
Oncogene amplification: Myc and neu oncoproteins (2018) (0)
Max Activity ls Affected by Phosphorylation at (1994) (0)
Abstract 861: Angiopoietin-2 blocking antibodies improve tumor growth inhibition and survival in mice treated with low doses of radiation (2018) (0)
Distinct Fibroblast Subtypes Populate Specific Brain Barriers (2022) (0)
Regulation of B2 and pS2 expression by estrogen and anitestrogens in human breast cancer cells (1990) (0)
Abstract 1908: The Wnt-target Prox1 promotes colorectal cancer stem cell survival to fuel tumor growth (2014) (0)
Substrate of tyrosine specific protein kinases p 36 colocalizes with nonerythrocyte alpha spectrin in surface lamina of cultured fibroblasts (1983) (0)
Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations (2012) (0)
Expression of the N- myc protooncogene in human foetal brain, retina and kidney (1987) (0)
Therapeutic potential of vascular growth factors (2018) (0)
Females are not dependent on MPS-driven hyperplasia of the lymph capillary network for internal environment and blood pressure control (2011) (0)
Oncogene amplification and tumor suppressor genes in lung cancer (1991) (0)
Abstract 532: Periadventitial Adenoviral Ang-1/2 Gene Transfer Interferes with Atherosclerotic Plaque Progression and Angiogenesis in the Carotid Artery of LDLr -/- ApoB100/100 Mice (2012) (0)
2016 Reviewer Acknowledgment (2017) (0)
PROX1 is a transcriptional regulator of MMP14 (2018) (0)
73: Parainflammation in cancer (2014) (0)
0128: Antiangiogenic Gene Therapy with Soluble Vegf Receptors Flt-1, Kdr and Flt-4 Inhibits the Growth of Human Solid Ovarian Tumors (2006) (0)
Amplification of Cellular Oncogenes in Colon and Lung Cancer Cells (1985) (0)
Angiopoietins, TIEs, Ephrins, VEGFs and VEGFRs (2004) (0)
CardioprotectionCells Contributes to Ischemic Activation of Hypoxia Response in (2014) (0)
Systemic Inhibition of Angiopoietin-2 Prevents Endothelial Activation, and Acute Rejection in Rat Cardiac Allografts (2013) (0)
New Approaches to Pathogenesis and Management of Hypertension (2009) (0)
Abstract 1143: Prox1 and Notch mark distinct colorectal cancer stem cell populations (2018) (0)
PericellularMatrix and Cell Surface Glycoproteinsof Virus transformedMouse EpithelialCells' of the regulation of cell growth and (2006) (0)
Acknowledgement to graders. (2016) (0)
murine neurogenesis Vascular endothelial growth factor receptor 3 directly regulates Material (2011) (0)
[Year 2000 Anders Jahre young scientist award to Lauri Aaltonen and Tomi Mäkelä]. (2000) (0)
Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival (2018) (0)
[The biology of lymphatic vessels - new findings ]. (1998) (0)
Materials and methods for growth factor binding constructs (2005) (0)
Bmx tyrosine kinase has a redundant function downstream of growth factor receptors in arterial endothelium (2001) (0)
Response to Letter Regarding Article, “Biological Basis of Therapeutic Lymphangiogenesis” (2011) (0)
An extracellular motif localizes receptor tyrosine kinases to membrane platforms for selective STAT activation (2019) (0)
Monoclonal antibodies against the tie-receptor and their use (1995) (0)
Crystal structure of vascular endothelial growth factor D (2011) (0)
Subject Index to Volume 15 (2001) (0)
Growth Factor Regulation of Physiologic Angiogenesis in the Mammary Gland (2001) (0)
Growth factor regulation of angiogenesis lymphangiogenesis and metastasis (2002) (0)
444: Persistent PDGF-A, -C, -D transgene expression enhances cardiac allograft vasculopathy and fibrosis, but PDGF-B induces myocardial angiogenesis (2007) (0)
Table of Contents (1991) (0)
Abstract IA16: Combinatorial targeting of angiogenic growth factor pathways (2015) (0)
In vivo SPECT/CT imaging of human ovarian carcinoma with monoclonal antibodies to EGFR and VEGFR-3 in mouse model (2009) (0)
Ang1 Reduces Ischemia-Reperfusion Injury-Induced Microvascular Dysfunction and Chronic Rejection in Rat Cardiac Allografts: 1507 (2012) (0)
Overexpressed Csk Tyrosine Kinase Is Localized in Focal Adhesions, Causes Reorganization of (cid:97) v (cid:98) 5 Integrin, and Interferes with HeLa Cell Spreading (1995) (0)
Growth factor-b, specific for vascular endothelial cells (1996) (0)
Abstract A026: PROX1 transcription factor regulates rhabdomyosarcoma growth, myogenic properties and therapeutic targets (2022) (0)
Increased EPA/TIMP and characterize TPA-induced megakaryoblastic differentiation of K562 cells (1990) (0)
Material and process the hybridvaskularendothelwachstumfaktoren dns and contain proteins and screening methods for modulators (2001) (0)
Growth Factors, Oncogenes and Cancer (1988) (0)
VEGF-C receptor ligand. (1996) (0)
Dural lymphatics regulate clearance of extracellular tau from the CNS (2019) (0)
cell spreading. alpha v beta 5 integrin, and interferes with HeLa in focal adhesions, causes reorganization of Overexpressed Csk tyrosine kinase is localized (2013) (0)
High baseline Tie1 predicts poor survival in metastatic breast cancer (2018) (0)
The blood vasculature instructs lymphatic patterning in a SOX7‐dependent manner (2021) (0)
PericellularMatrixandCell SurfaceGlycoproteins of Virus transformedMouseEpithelialCells (1982) (0)
Deposition ofanintermediate formofprocoliagen typeIII(pN-collagen) into fibrils inthematrixofamniotic epithelial cells (1982) (0)
Endothelial TIE1 restricts angiogenic sprouting to coordinate vein assembly in synergy with its homologue TIE2 (2022) (0)
VEGF-C/VEGFRS and Cancer Metastasis (2001) (0)
Notum inhibits local Wnt signalling to increase the competitiveness of Apc -mutant clones (2021) (0)
2SY04-6 Gene programs for lymph/angiogenesis (2003) (0)
66 Lymphangiogenic growth factors and tumor metastasis (2003) (0)
[Proto-oncogenes and the control of cell growth]. (1990) (0)
Tie: Tie protein-tyrosine kinase (vertebrates) (1995) (0)
331 COMP-Ang1 Reduces Ischemia-Reperfusion Injury-Induced Microvascular Dysfunction and Chronic Rejection in Rat Cardiac Allografts (2012) (0)
Short title for running head: VEGFR-3+ lymphatic/vascular endothelial precursors (2016) (0)
965. Lymphatic and Systemic Metastasis of Prostate Cancer Induced by VEGF-C (2006) (0)
D growth factor, platelet derived DNA encoding the same and their uses. (1999) (0)
Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels Integrative Physiology (2008) (0)
EFFICIENT AND LONG-LASTING ADENO-ASSOCIATED VIRUS 8 (AAV8) VECTOR –MEDIATED TRANSGENE EXPRESSION IN HEART TRANSPLANT MYOCARDIUM: 549 (2008) (0)
Judah Folkman (1933–2008) (2008) (0)
VEGFs and Receptors in Angiogenesis and Lymphangiogenesis (2000) (0)
Abstract IA03: Combinatorial targeting of endothelial growth factor pathways (2015) (0)
Publisher Correction: VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours (2021) (0)
Growth factors and inhibitors of tumor angiogenesis and lymphatic metastasis (2012) (0)
389. Placental Growth Factor (PIGF) Gene Transfer to the Periadventitial Tissue (2004) (0)
STAT5b is a key effector of NRG-1/ERBB4-mediated cardiomyocyte 1 growth 2 Short title: STAT5b in NRG-1 mediated cardiac growth (2022) (0)
Lymphatic Endothelial Cell VEGFR3 Controls Cardiac Allograft Rejection (2015) (0)
Abstract LB-094: Systemic RSPO1 delivery leads to regression of intestinal adenomas via activation of the TGFβ/SMAD pathway (2019) (0)
Evidence Of Lymphatic Vessels In The Developing And Young Adult Human Retina and Choroid (2011) (0)
Abstract 1625: Clinical biomarkers of survival in renal cell carcinoma patients treated with sorafenib (2018) (0)
Abstract 3634: Selective targeting of tumor-associated angiogenic tip and stalk cells with immunoliposomes (ILs) directed against VEGFR-2 and VEGFR-3 expressing cells (2011) (0)
Uses of platelet-derived growth factor-d, encoding it and their dns (1999) (0)
Modeling lymphangiogenesis in a 3 D-culture system (2009) (0)
Consensus guidelines for the use and interpretation of angiogenesis assays (2018) (0)
VEGF inhibitors for anti-angiogenic therapy (2007) (0)
443: VEGFR-3 mediates lymphangiogenesis and alloimmune responses in cardiac allografts (2007) (0)
Personal Profiles (2007) (0)
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1 (2017) (0)
2017 Reviewer Acknowledgment (2018) (0)
Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Commentary (2006) (0)
Lymphangiogenesis: a new paradigm for cancer progression and therapy (2009) (0)
Abstract 2320: Prox1 marks a stem cell population that promotes tumor progression in intestinal adenomas (2015) (0)
Oncogenes: from bursal to Burkitt lymphoma (1987) (0)
Expression vectors and cell lines for expression of vascular growth factor-d, as well as methods for the treatment of melanoma (1998) (0)
The fatal detachment (2001) (0)
Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2 (2010) (0)
Molecular Mechanisms Controlling Susceptibitliy to Tumor Necrosis Factor Induced Cell Death (1996) (0)
HPSC-derived organoids express intestinal marker genes at levels comparable to human intestinal epithelium. (2015) (0)
Subcellular location of an abundant substrate (p36) for tyrosine-specific protein kinases (1983) (0)
Hypertrophy Induced Cardiac - Loss of Bmx Nonreceptor Tyrosine Kinase Prevents Pressure Overload (2013) (0)
PO9-270 VEGFR-3 MEDIATES LYMPHANGIOGENESIS AND ALLOIMMUNE RESPONSES IN CARDIAC ALLOGRAFTS (2007) (0)
β-catenin plus PROX1 immunostaining stratifies disease progression and patient survival in neoadjuvant-treated pancreatic cancer. (2022) (0)
Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation (2023) (0)
234Models for VEGF-B induced physiological and pathological cardiac hypertrophy (2018) (0)
binding and specificity Structural determinants of vascular endothelial growth factor-D receptor (2011) (0)
(double minute chromosomes/chromosome aberrations/retroviruses/ (2016) (0)
mutation VEGFR3 caused by a Recessive primary congenital lymphoedema (2009) (0)
Growth factor vascular endothelial cells recombinant d (vegf-d). (1997) (0)
VEGF-B Overexpression Enhances Ischemia-Reperfusion Injury and the Innate Immune Response in Rat Heart Transplants (2015) (0)
The angiopoietin receptor Tie2 in arterial endothelium inhibits atherosclerosis (2021) (0)
Abstract 2976: KSHV-initiated Notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition (2012) (0)
Human Endothelial Cells in Activates Src via a Tyrosyl Phosphatase-dependent Pathway 1 and Caveolin-1, and β 5 α Endostatin Associates with Integrin (2013) (0)
Novel tyrosine kinases expressed in the K562 human leukemia cells (1990) (0)
566 Co-amplification of a novel cyclophilin-like gene with MYCL1 in small cell lung cancer (SCLC) cell lines (1997) (0)
[The evaluation of prognosis of breast cancer]. (1991) (0)
Peptide-based treatment for autoimmune diseases : learning how to handle a double-edged sword (0)
[Changes in tumor suppressor genes as a mechanism in causing cancer]. (1991) (0)
PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma (2016) (0)
STAT5b is a key effector of NRG‐1/ERBB4‐mediated myocardial growth (2023) (0)
[Lentiviruses to use]. (2003) (0)
Oncogene amplification: the role of Myc overexpression in tumorigenesis (1992) (0)
Vegf-c binding of receiver. (1996) (0)
Perioperative single-dose VEGF-C/D inhibitor enhances cardiac allograft survival and prevents chronic rejection by regulating lymphatic endothelial cell activation (2014) (0)
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats. (2023) (0)
[Transforming growth factor-beta and malignant growth]. (1986) (0)
Antibody targeting of endothelial Tie1 receptor as an anti-angiogenic sensitizer in tumor therapy (2008) (0)
Kinase-Independent Manner Mediator of Inflammatory Arthritis in a The Tyrosine Kinase BMX Is an Essential (2011) (0)
Retroviruses in Neoplasia Yesterday, Today and Tomorrow (1985) (0)
particular discourse on the parietal cell expression profiling gastric epithelial cells with a How form follows functional genomics: gene (2015) (0)
The lymphatic ring assay: a 3D culture system for discovering novel genes and mechanisms that regulate lymphangiogenesis (2007) (0)
Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel (2006) (0)
[The risk genes of familial breast cancer can be identified]. (1995) (0)
Crystal structure of VEGF-C in complex with VEGFR-3 domains D1-2 (2013) (0)
Molecular Players in Lymphangiogenesis (2008) (0)
uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis (2018) (0)
ORAI1 Controls the Unique Adjustment of Lymphatics to Fluid Flow. (2017) (0)
The RelatedFLT4, FLT1, and KDR Receptor TyrosineKinasesShow DistinctExpressionPatterns in Human FetalEndothelialCells (1993) (0)
endothelial cell junctions Angiopoietin 2 regulates the transformation and integrity of lymphatic Material Supplemental (2014) (0)
Lymphatic Drainage Mice That Lack Dermal K14-VEGFR-3-Ig in Impaired Humoral Immunity and Tolerance (2012) (0)
974. Adeno-Associated Viral (AAV)-Mediated Gene Transfer of Soluble Vascular Endothelial Growth Factor Receptor 3 (sVEGFR3) Inhibits Development of Lymph Node Metastases (2004) (0)
385: Expression of a Stablized Hypoxia Inducible Factor-1α Reduces Cardiomyocyte Apoptosis and Prevents Cardiac Allograft Vasculopathy (2010) (0)
Origins of human cancer: A comprehensive review: edited by Joan Brugge, Tom Curran, Ed Harlow and Frank McCormick, Cold Spring Harbor Laboratory Press, 1991. $80.00 (xvi + 904 pages) ISBN 0 87969 404 1 (1992) (0)
Main Session V: Oncogenes (2009) (0)
Blocking lymphatic vessel function with soluble VEGFR3 in atherosclerotic mouse model alters lipoprotein metabolism and enhances atherogenesis (2013) (0)
Increased expression of Flt4 (vascular endothelial growth factor receptor-3) in duodenal mucosa of patients with protein-losing enteropathy (2001) (0)
Angiogenesis and lymphangiogenesis profiles of human VEGFs (2002) (0)
A chimeric EGFR/neu receptor in studies of neu function. (1992) (0)
Article on Role of Angiopoietin-1 in Tumor Metastasis (2009) (0)
Donor Single-dose Treatment with VEGFR-3 Antibody Reduces Acute Alloimmune Response by Targeting Lymphatic Endothelial Cell Activation (2014) (0)
Comparison of Automated and Traditional Western Blotting Methods (2023) (0)
Chapter 1 LYMPHANGIOGENESIS IN HEALTH AND DISEASE – AN OVERVIEW (0)
Plaque lymphangiogenesis: To drain or not to drain (2016) (0)
[Molecular genetics and biology in the etiology of cancer]. (1993) (0)
Flt4 (VEGFR-3) as a target for tumor detection (imaging) and anti-tumor therapy (1999) (0)
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1 (2023) (0)
Lymphangiogenic Potential Of Cells Isolated From Chylous Pleural Effusions Of LAM Patients (2010) (0)
Science Signaling Podcast: 2 July 2013 (2013) (0)
Tuomas Tammela Cells Prevents Metastasis Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer (2011) (0)
Author response: KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D (2019) (0)
Ex Vivo Intracoronary Gene Transfer of Adeno Associated Virus Serotype 2 Is Superior to Serotypes 8 and 9 in Transfecting Heart Transplants in the Rat (2013) (0)
recombinant growth factor vascular endothelial cell-D (VEGF-D) (1997) (0)
PROX1 transcription factor controls rhabdomyosarcoma growth, stemness, myogenic properties and therapeutic targets. (2022) (0)
Homodimerization of Tie2 Fibronectin-like domains 2 and 3 in space group P21 (2017) (0)

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