Karim Nayernia
#52,035
Most Influential Person Now
Iranian scientist
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Karim Nayerniabiology Degrees
Biology
#3783
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#5737
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Biotechnology
#260
World Rank
#262
Historical Rank
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Biology
Karim Nayernia's Degrees
- Masters Biotechnology University of Tehran
- Bachelors Biology University of Tehran
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Why Is Karim Nayernia Influential?
(Suggest an Edit or Addition)According to Wikipedia, Karim Nayernia is an Iranian biomedical scientist and a world expert on stem cell biology and Personalized medicine. He carried out pioneering work that has the potential to lead to future therapies for a range of medical conditions such as heart disease, Parkinson's disease and male infertility. His team was the first in the world to isolate a new type of stem cell from adult mouse testes , called spermatagonial stem cells. It was able to show that some of these stem cells, called multipotent adult germline stem cells , turned into heart, muscle, brain and other cells. Prof Nayernia and his team proposed that similar cells could be extracted from men using a simple testicular biopsy. On the basis of these cells, new stem cell techniques could be developed in order to treat a variety of illnesses.
Karim Nayernia's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Pluripotency of spermatogonial stem cells from adult mouse testis (2006) (888)
- Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. (1999) (673)
- In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice. (2006) (508)
- Derivation of male germ cells from bone marrow stem cells (2006) (318)
- Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. (2006) (250)
- Male mice deficient for germ-cell cyritestin are infertile. (1999) (237)
- Spermatozoa lacking acrosin protein show delayed fertilization (1997) (184)
- Teratozoospermia in mice lacking the transition protein 2 (Tnp2). (2001) (137)
- Stem cell based therapeutical approach of male infertility by teratocarcinoma derived germ cells. (2004) (136)
- Generation of Functional Cardiomyocytes From Adult Mouse Spermatogonial Stem Cells (2007) (136)
- Translational control in spermatogenesis. (1995) (133)
- Asthenozoospermia in Mice with Targeted Deletion of the Sperm Mitochondrion-Associated Cysteine-Rich Protein (Smcp) Gene (2002) (115)
- Putative human male germ cells from bone marrow stem cells. (2007) (107)
- Isolation and cultivation of stem cells from adult mouse testes (2009) (105)
- Pathways of proliferation and antiapoptosis driven in breast cancer stem cells by stem cell protein piwil2. (2010) (101)
- Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes (2006) (88)
- Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles. (2008) (70)
- BMP4 can generate primordial germ cells from bone‐marrow‐derived pluripotent stem cells (2012) (64)
- Stage and developmental specific gene expression during mammalian spermatogenesis. (1996) (57)
- Expression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer (2012) (56)
- Premature translation of transition protein 2 mRNA causes sperm abnormalities and male infertility (2007) (55)
- Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. (2001) (54)
- Inactivation of a Testis-specific Lis1 Transcript in Mice Prevents Spermatid Differentiation and Causes Male Infertility* (2003) (53)
- Phospholipid hydroperoxide glutathione peroxidase: expression pattern during testicular development in mouse and evolutionary conservation in spermatozoa (2004) (48)
- Adult Germ Line Stem Cells as a Source of Functional Neurons and Glia (2008) (44)
- Generation of functional neurons and glia from multipotent adult mouse germ-line stem cells. (2009) (44)
- Inflammatory Microenvironment of Acute Myocardial Infarction Prevents Regeneration of Heart with Stem Cells Therapy. (2019) (44)
- Disruption of PLC-β1-Mediated Signal Transduction in Mutant Mice Causes Age-Dependent Hippocampal Mossy Fiber Sprouting and Neurodegeneration (2002) (40)
- Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene (2006) (40)
- Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse (2004) (40)
- Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules (2009) (39)
- Mutation analysis in hereditary haemorrhagic telangiectasia in Germany reveals 11 novel ENG and 12 novel ACVRL1/ALK1 mutations (2006) (35)
- Potency of germ cells and its relevance for regenerative medicine (2008) (33)
- Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility. (2002) (31)
- Functional and molecular characterization of the transcriptional regulatory region of the proacrosin gene. (1994) (30)
- PSCDGs of mouse multipotent adult germline stem cells can enter and progress through meiosis to form haploid male germ cells in vitro. (2010) (29)
- Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse. (2008) (27)
- Triple knockouts reveal gene interactions affecting fertility of male mice (2005) (25)
- Mice deficient for RNA‐binding protein brunol1 show reduction of spermatogenesis but are fertile (2007) (25)
- Co-culture of Mouse Embryonic Stem Cells with Sertoli Cells Promote in vitro Generation of Germ Cells (2013) (24)
- Diploid expression and translational regulation of rat acrosin gene. (1994) (24)
- Male Mice Lacking Three Germ Cell Expressed Genes Are Fertile1 (2003) (23)
- A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-sertoli cell interaction. (1999) (22)
- A Novel In Vitro Model for Cancer Stem Cell Culture Using Ectopically Expressed Piwil2 Stable Cell Line (2013) (21)
- Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6). (2003) (20)
- Stem Cell and Tissue Engineering Research in the Islamic Republic of Iran (2012) (20)
- Evaluation of in vitro spermatogenesis system effectiveness to study genes behavior: monitoring the expression of the testis specific 10 (Tsga10) gene as a model. (2014) (19)
- Male Mice Lacking the Theg (Testicular Haploid Expressed Gene) Protein Undergo Normal Spermatogenesis and Are Fertile1 (2003) (19)
- ALK‐1 mutations in liver transplanted patients with hereditary hemorrhagic telangiectasia (2005) (18)
- Spermatogonial stem cells. (2004) (17)
- Stem cells derived from testis show promise for treating a wide variety of medical conditions (2007) (17)
- Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals (2000) (16)
- In Vitro–Derived Gametes from Stem Cells (2013) (16)
- In vitro differentiation process of human Wharton’s jelly mesenchymal stem cells to male germ cells in the presence of gonadal and non-gonadal conditioned media with retinoic acid (2015) (16)
- Retinoic acid induces mouse bone marrow‐derived CD15+, Oct4+ and CXCR4+ stem cells into male germ‐like cells in a two‐dimensional cell culture system (2014) (15)
- Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. (2006) (15)
- Generation and Characterization of a Transgenic Mouse with a Functional Human TSPY1 (2003) (14)
- Differentiation of bone marrow‐derived stage‐specific embryonic antigen 1 positive pluripotent stem cells into male germ cells (2017) (14)
- RETRACTION - In Vitro Derivation of Human Sperm from Embryonic Stem Cells. (2009) (14)
- Calgizarrin like gene (Cal) deficient mice undergo normal spermatogenesis (2003) (13)
- Isolation and characterization of differentially expressed genes in invasive and non-invasive immortalized murine male germ cells in vitro. (2001) (12)
- Yeast one-hybrid assay identifies YY1 as a binding factor for a proacrosin promoter element. (1999) (11)
- Application of Stem Cell Technologies to Regenerate Injured Myocardium and Improve Cardiac Function. (2019) (10)
- Characterization of a human TSPY promoter (2005) (9)
- TSPY-LTA transgenic mice develop endocrine tumors of the pituitary and adrenal gland (2003) (9)
- Synergistic effects of germ cell expressed genes on male fertility in mice. (2003) (8)
- Rat transition nuclear protein 2 regulatory region directs haploid expression of reporter gene in male germ cells of transgenic mice * (2001) (8)
- Asthenoteratozoospermia in mice lacking testis expressed gene 18 (Tex18). (2007) (8)
- A 74-bp promoter of the Tnp2 gene confers testis- and spermatid-specific expression in transgenic mice. (2001) (7)
- ADAM family genes testase 2α and 2β are chromosomally linked and simultaneously expressed in male germ cells (2003) (7)
- From stem cells to germ cells and from germ cells to stem cells (2007) (6)
- DNA-protein binding studies in the 5' flanking region of rat proacrosin gene which is transcribed in diploid germ cells. (1995) (5)
- Refinement of the expression pattern of a mouse homologue of the porcine 135-kDa alpha-d-mannosidase (MAN2B2). (2000) (4)
- Targeted expression of SV40 large tumour antigen (TAg) induces a transient enhancement of spermatocyte proliferation and apoptosis. (2001) (4)
- MicroRNA profiling during germline differentiation of mouse embryonic stem cells. (2015) (3)
- A newborn with hereditary haemorrhagic telangiectasia and an unusually severe phenotype. (2008) (3)
- Molecular and cellular approaches for establishment of an in vitro spermatogenesis system. (2004) (3)
- ADAM family genes testase 2alpha and 2beta are chromosomally linked and simultaneously expressed in male germ cells. (2003) (2)
- [Genetic causes of male infertility]. (2004) (2)
- Stem cells-derived natural killer cells for cancer immunotherapy: current protocols, feasibility, and benefits of ex vivo generated natural killer cells in treatment of advanced solid tumors (2021) (2)
- THE ROLE OF ACROSIN IN REPRODUCTION (2000) (2)
- Germ cells, origin of somatic stem cells? (2008) (2)
- WITHDRAWN; Impaired spermatogenesis in mice overexpressing stem cell protein Piwil2 (Mili) (2010) (1)
- Subject Index Vol. 90, 2000 (2000) (1)
- Investigation of key signaling pathways and appropriate diagnostic biomarkers selection between non-invasive to invasive stages in pancreatic cancer: a computational observation (2022) (1)
- Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells (2022) (1)
- Overexpression of Lis1 in Different Stages of Spermatogenesis Does Not Result in an Aberrant Phenotype (2011) (1)
- Running title : In Vitro Derived Human Sperm Title : Derivation of Human Sperm from Embryonic Stem Cells (2009) (0)
- Abstract 521: Generation of Functional Cardiomyocytes from Adult Mouse Spermatogonial Stem Cells (2006) (0)
- In vitro differentiation process of human Wharton’s jelly mesenchymal stem cells to male germ cells in the presence of gonadal and non-gonadal conditioned media with retinoic acid (2015) (0)
- Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis (2021) (0)
- INVITED SPEAKERS: I-19: IN VITRO DERIVED GAMETES: A MODEL FOR STUDYING MOLECULAR AND CELLULAR BIOLOGY OF GERM CELLS (2011) (0)
- Contents Vol. 134, 2011 (2011) (0)
- Stem Cell and Tissue Engineering Research in the Islamic Republic of Iran (2012) (0)
- PS-1.2 Sperm differentiation from stem cells (2008) (0)
- Contents Vol. 90, 2000 (2000) (0)
- Stem Cell–Based Therapeutic Approaches forTreatment of Male Infertility (2009) (0)
- Personalized diagnostics and treatment of breast cancer (2014) (0)
- Ectopic expression of OCT4B1 Decreases Fertility Rate and Changes Sperm Parameters in Transgenic Mice (2022) (0)
- Stem-cell regulatory protein Piwil2 enriches for known stem-cell and cancer stem-cell markers in prostate cancer cells (2011) (0)
- TESTICULAR STEM CELLS AS A PROMISING SOURCE OF PLURIPOTENT STEM CELLS (2009) (0)
- Report of a Patient with Multiple Mutations Leading to CharcotMarie-Tooth Disease and Distal Spinal Muscular Atrophy: A Case Report (2020) (0)
- New Developments in Stem Cell Research (2009) (0)
- Procede de diagnostic d’un cancer (2005) (0)
- Evaluation of in vitro Spermatogenesis System Effectiveness to Study Genes Behavior: Monitoring the Expression of the Testis 6SHFLøF7VJD*HQHDVD0RGHO (2014) (0)
- STEM CELLS IN MALE REPRODUCTION (2009) (0)
- A vector-based system for the differentiation of mouse embryonic stem cells toward germ-line cells (2014) (0)
- Abstracts of the 2nd International Student’s Award & Congress in Reproductive Medicine (2007) (0)
- C20 Germ cells from stem cells and reprogrammed somatic cells (2010) (0)
- Multiorgan engraftment and differentiation of mouse-induced pluripotent stem cells in rats: a roadmap towards personalised stem cell medicine (2014) (0)
- Compositions et procedes de production de cellules pluripotentes a partir de testicules adultes (2006) (0)
- In vivo interspecies stem cell-based tissue engineering: A roadmap towards personalized stem cell medicine (2013) (0)
- IN VITRO DERIVED GAMETES: REALITY AND PERSPECTIVES IN HUMAN ASSISTED REPRODUCTION (2011) (0)
- Reprogramming Male Germ Cells to Pluripotent Stem Cells (2009) (0)
- Hematopoietic and Endothelial Progenitor Cells from Mouse Adult Testis Derived Stem Cell Lines. (2006) (0)
- A Case Report of Genetic Cascade Screening in Dilated Cardiomyopathy: A Perspective for Preventive Cardiology (2021) (0)
- Antisense RNA to the type I insulin-like growth factor receptor reversed the transformed phenotype of PC-3 human prostate cancer cell line in vitro (2003) (0)
- Risk of secondary tumours in patients with non-metastatic and metastatic human retinoblastoma. (2022) (0)
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