Karine Auclair
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Computer Science
Karine Auclair's Degrees
- PhD Computer Science Université de Montréal
- Masters Computer Science Université de Montréal
- Bachelors Computer Science Université de Montréal
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Why Is Karine Auclair Influential?
(Suggest an Edit or Addition)According to Wikipedia, Karine Auclair is a professor of chemistry at McGill University in Montréal, Canada. She is the current Canada Research Chair in Antimicrobials and Green Enzymes. Education and career Auclair completed a Bachelor of Science in chemistry at Université du Québec à Chicoutimi in 1994, followed by a Doctor of Philosophy in organic chemistry at the University of Alberta in 1999. She then completed a post-doctoral fellowship in pharmaceutical chemistry at the University of California, San Francisco from 1999 to 2001.
Karine Auclair's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. (1999) (591)
- Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis (2018) (331)
- Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue (2000) (195)
- Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. (2004) (117)
- Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane. (2002) (113)
- Roles of the proximal heme thiolate ligand in cytochrome p450(cam). (2001) (109)
- Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages (2020) (107)
- Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases (2000) (97)
- Progress towards the easier use of P450 enzymes. (2006) (90)
- Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. (2008) (84)
- Composition and biological activity of traditional and commercial kava extracts. (2004) (74)
- Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme (2011) (73)
- Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. (2006) (67)
- Solvent-Free Enzyme Activity: Quick, High-Yielding Mechanoenzymatic Hydrolysis of Cellulose into Glucose. (2018) (61)
- Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6 (2006) (52)
- Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases. (2005) (52)
- Elucidating Protein Binding Mechanisms by Variable‐c ITC (2009) (47)
- Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. (2003) (44)
- CYP3A4 Activity in the Presence of Organic Cosolvents, Ionic Liquids, or Water‐Immiscible Organic Solvents (2007) (42)
- Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4. (2011) (38)
- Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase. (2008) (38)
- Inhibition of human P450 enzymes by nicotinic acid and nicotinamide. (2004) (35)
- Mechanoenzymatic breakdown of chitinous material to N-acetylglucosamine: the benefits of a solvent-less environment. (2019) (35)
- Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus. (2001) (35)
- Global ITC fitting methods in studies of protein allostery. (2015) (33)
- Recent advances in the biosynthetic studies of lovastatin. (2001) (32)
- Allosteric Activation of Cytochrome P450 3A4 via Progesterone Bioconjugation. (2017) (29)
- 1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1. (2002) (29)
- Mechanoenzymatic Transformations in the Absence of Bulk Water: A More Natural Way of Using Enzymes (2020) (28)
- Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase. (2008) (28)
- Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues (2011) (28)
- Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance. (2009) (26)
- Solution NMR Characterization of an Unusual Distal H-bond Network in the Active Site of the Cyanide-inhibited, Human Heme Oxygenase Complex of the Symmetric Substrate, 2,4-Dimethyldeuterohemin* 210 (2002) (26)
- Efficient Enzymatic Hydrolysis of Biomass Hemicellulose in the Absence of Bulk Water (2019) (25)
- Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues (2017) (24)
- Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited human heme oxygenase: water occupation of the distal cavity. (2003) (22)
- Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis. (2014) (21)
- Towards controlling the reactivity of enzymes in mechanochemistry: inert surfaces protect β-glucosidase activity during ball milling. (2019) (21)
- Enzymatic depolymerization of highly crystalline polyethylene terephthalate enabled in moist-solid reaction mixtures (2021) (20)
- Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme. (2014) (20)
- Inhibitors of aminoglycoside resistance activated in cells. (2012) (20)
- Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency (2016) (20)
- Solution 1H NMR of the Active Site of Substrate-bound, Cyanide-inhibited Human Heme Oxygenase (2001) (20)
- Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity. (2011) (19)
- Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6. (2007) (19)
- 3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors. (2016) (19)
- Van't Hoff global analyses of variable temperature isothermal titration calorimetry data. (2012) (18)
- Site-specific fluorescent labeling and oriented immobilization of a triple mutant of CYP3A4 via C64. (2012) (16)
- Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase. (2012) (16)
- Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity. (2014) (15)
- Small Molecule Restores Itaconate Sensitivity in Salmonella enterica: A Potential New Approach to Treating Bacterial Infections (2016) (15)
- Dual use of a chemical auxiliary: molecularly imprinted polymers for the selective recovery of products from biocatalytic reaction mixtures (2012) (13)
- The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activity. (2007) (12)
- Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase. (2014) (12)
- 1H NMR Investigation of the Solution Structure of Substrate-free Human Heme Oxygenase (2004) (11)
- A cross-metathesis approach to novel pantothenamide derivatives (2016) (11)
- An Overview of Molecular Spectroscopic Studies on Theobromine and Related Alkaloids (2012) (11)
- Regioselective Epoxidations by Cytochrome P450 3A4 Using a Theobromine Chemical Auxiliary to Predictably Produce N‐Protected β‐ or γ‐Amino Epoxides (2017) (11)
- A Covalently Attached Progesterone Molecule Outcompetes the Binding of Free Progesterone at an Allosteric Site of Cytochrome P450 3A4. (2019) (11)
- Use of bioconjugation with cytochrome P450 enzymes. (2018) (11)
- Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates. (2015) (9)
- Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. (2003) (9)
- Type II Ligands as Chemical Auxiliaries To Favor Enzymatic Transformations by P450 2E1 (2012) (9)
- Structure–Activity Relationships of Antiplasmodial Pantothenamide Analogues Reveal a New Way by Which Triazoles Mimic Amide Bonds (2018) (9)
- Rapid mechanoenzymatic saccharification of lignocellulosic biomass without bulk water or chemical pre-treatment (2020) (9)
- Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity (2017) (9)
- Effect of pH on the antimicrobial activity of the macrophage metabolite itaconate. (2021) (8)
- Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase. (2011) (7)
- Highly Efficient P(III)-to-P(V) Oxidative Rearrangement (2006) (6)
- Inhibition and activation of kinases by reaction products: a quick, reporter-free assay. (2019) (6)
- Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency. (2018) (6)
- Molecular Genetics of Lovastatin and Compactin Biosynthesis (2004) (6)
- Metabolic Instability of Cyanothiazolidine‐Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications (2015) (6)
- Clean Enzymatic depolymerization of highly crystalline polyethylene terephthalate in moist-solid reaction mixtures (2020) (6)
- Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides. (2021) (5)
- Activity of human P450 2D6 in biphasic solvent systems. (2007) (5)
- The activity of human CYP2D6 in low water organic solvents (2009) (5)
- Mechanoenzymatic Reactions Involving Polymeric Substrates or Products. (2022) (5)
- Collecting variable-concentration isothermal titration calorimetry datasets in order to determine binding mechanisms. (2011) (5)
- Cellular Studies of an Aminoglycoside Potentiator Reveal a New Inhibitor of Aminoglycoside Resistance (2018) (5)
- Semisynthetic transformation of banana peel to enhance the conversion of sugars to 5-hydroxymethylfurfural. (2022) (4)
- Probing the ligand preferences of the three types of bacterial pantothenate kinase. (2018) (4)
- The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation. (2019) (3)
- Solid-state enzymatic hydrolysis of mixed PET-cotton textiles (2022) (3)
- Semisynthetic production of hydroxymethylfurfural and furfural: The benefits of an integrated approach. (2022) (3)
- Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase. (2021) (3)
- Combining Small-Molecule Bioconjugation and Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) to Expose Allostery: the Case of Human Cytochrome P450 3A4. (2021) (2)
- Ammonium Chloride‐Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation (2021) (2)
- Mutations in the pantothenate kinase of the malaria parasite P. falciparum confer resistance or hypersensitivity to diverse pantothenate analogues (2017) (2)
- Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides (2020) (2)
- Enzymes Beat Chemists in the Formation of an Unnatural Bond (2017) (1)
- The antimicrobial activity of the macrophage metabolite itaconate is synergistic with acidity (2020) (1)
- Combining small-molecule bioconjugation and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to expose allostery: the case of human cytochrome P450 3A4 (2020) (1)
- TECHNIQUES IN ORGANIC CHEMISTRY, PART 1 : VHS VIDEOTAPE : ABSTRACT OF SPECIAL ISSUE 20 (1998) (1)
- Techniques in Organic Chemsitry, Part 2: Videotape (1998) (1)
- Back Cover: Metabolic Instability of Cyanothiazolidine‐Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications (ChemMedChem 7/2015) (2015) (1)
- Itaconate: an antimicrobial metabolite of macrophages (2021) (1)
- Inside Cover: Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues (ChemMedChem 11/2011) (2011) (1)
- Cover Feature: Mechanoenzymatic Transformations in the Absence of Bulk Water: A More Natural Way of Using Enzymes (ChemBioChem 6/2020) (2020) (0)
- Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductase (2021) (0)
- 1 H NMR Investigation of the Solution Structure of Substrate-free (2004) (0)
- Efficient mechano-enzymatic hydrolysis of polylactic acid under moist-solid conditions (2022) (0)
- Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis (2018) (0)
- Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue (2011) (0)
- Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages (2020) (0)
- P1-162 Progress towards the synthesis of a stable alpha-helical amyloid-β peptide (2004) (0)
- Cover Feature: Mechanoenzymatic Breakdown of Chitinous Material to N ‐Acetylglucosamine: The Benefits of a Solventless Environment (ChemSusChem 15/2019) (2019) (0)
- Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6 (2007) (0)
- Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine. (2008) (0)
- Biosynthetic studies on the polyketide lovastatin: enzyme-catalyzed diels-alder reactions (1999) (0)
- Small molecule resensitizes Salmonella to itaconate and decreases bacterial proliferation in macrophages (2020) (0)
- Solution 1 H NMR of the Active Site of Substrate-bound, Cyanide-inhibited Human Heme Oxygenase COMPARISON TO THE CRYSTAL STRUCTURE OF THE WATER-LIGATED FORM* h S (2001) (0)
- Comparative evaluation of metabolic, electrophilic, and immunologic effects of itaconate and its ester derivatives on macrophage activation (2020) (0)
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