Karl Kunzelmann
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(Suggest an Edit or Addition)Karl Kunzelmann's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. (1994) (927)
- Electrolyte transport in the mammalian colon: mechanisms and implications for disease. (2002) (677)
- Ion Channels and Cancer (2005) (447)
- Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels (2006) (274)
- TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. (2012) (239)
- Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport* (2009) (221)
- The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways. (1998) (218)
- Transfer and expression of foreign genes in mammalian cells. (2000) (181)
- Anoctamins are a family of Ca2+-activated Cl− channels (2012) (170)
- TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A* (2009) (165)
- Wild type but not ΔF508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes (1996) (165)
- Expression and function of epithelial anoctamins (2012) (161)
- Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis. (2007) (155)
- Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator (1997) (151)
- Enhanced Expression of ANO1 in Head and Neck Squamous Cell Carcinoma Causes Cell Migration and Correlates with Poor Prognosis (2012) (145)
- Anoctamin 6 is an essential component of the outwardly rectifying chloride channel (2011) (144)
- Calmodulin‐dependent activation of the epithelial calcium‐dependent chloride channel TMEM16A (2011) (141)
- The role of the IsK protein in the specific pharmacological properties of the IKs channel complex (1997) (137)
- Purinergic inhibition of the epithelial Na+ transport via hydrolysis of PIP2 (2005) (131)
- Cl− transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co‐expressing CFTR and ENaC (1998) (131)
- Expression of Voltage-Gated Potassium Channels in Human and Mouse Colonic Carcinoma (2007) (130)
- The Cystic Fibrosis Transmembrane Conductance Regulator Activates Aquaporin 3 in Airway Epithelial Cells* (1999) (125)
- Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia. (2000) (125)
- KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer (2007) (124)
- Phosphatidylserine exposure is required for ADAM17 sheddase function (2016) (123)
- Molecular and functional characterization of the small Ca2+-regulated K+ channel (rSK4) of colonic crypts (1999) (122)
- Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages (2015) (121)
- CFTR: interacting with everything? (2001) (121)
- An immortalized cystic fibrosis tracheal epithelial cell line homozygous for the delta F508 CFTR mutation. (1993) (119)
- Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions. (2009) (118)
- CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. (2004) (117)
- Modulation of Ca2+-Activated Cl− Secretion by Basolateral K+ Channels in Human Normal and Cystic Fibrosis Airway Epithelia (2003) (116)
- CFTR, A Regulator of Channels (1999) (116)
- Expression and Function of Epithelial Anoctamins* (2010) (114)
- 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. (2000) (113)
- Cholinergic ion secretion in human colon requires coactivation by cAMP. (1998) (110)
- The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon. (2004) (110)
- Role of K(V)LQT1 in cyclic adenosine monophosphate-mediated Cl(-) secretion in human airway epithelia. (2000) (108)
- The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular Cl− concentration (2001) (107)
- Control of epithelial Na+ conductance by the cystic fibrosis transmembrane conductance regulator (2000) (105)
- Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells (2015) (105)
- The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel. (1999) (104)
- Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments. (1998) (102)
- The cystic fibrosis transmembrane conductance regulator and its function in epithelial transport. (1999) (99)
- Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? (2014) (98)
- Voltage‐gated K channels support proliferation of colonic carcinoma cells (2007) (97)
- Rescue of the mineralocorticoid receptor knock-out mouse (1999) (96)
- Inhibition of amiloride-sensitive epithelial Na(+) absorption by extracellular nucleotides in human normal and cystic fibrosis airways. (2000) (96)
- Gene targeting of CFTR DNA in CF epithelial cells. (1996) (95)
- Disruption of the K+ Channel β-Subunit KCNE3 Reveals an Important Role in Intestinal and Tracheal Cl− Transport* (2010) (94)
- Bestrophin-1 Enables Ca2+-activated Cl− Conductance in Epithelia* (2006) (92)
- ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel (2010) (90)
- Role of anoctamins in cancer and apoptosis (2014) (90)
- Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption (2011) (88)
- Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways (2018) (87)
- Functional Properties of the Type-3 InsP3 Receptor in 16HBE14o− Bronchial Mucosal Cells* (1998) (87)
- Epithelial Chloride Transport by CFTR Requires TMEM16A (2017) (86)
- Regulation of Ion Transport in Colonic Crypts (1997) (84)
- Pharmacotherapy of the Ion Transport Defect in Cystic Fibrosis (2003) (82)
- Role of KCNMA1 in Breast Cancer (2012) (81)
- Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients. (2000) (80)
- CFTR: a hub for kinases and crosstalk of cAMP and Ca2+ (2013) (79)
- Mechanisms of the inhibition of epithelial Na(+) channels by CFTR and purinergic stimulation. (2001) (79)
- Differential effects of anoctamins on intracellular calcium signals (2017) (78)
- Cloning and Function of the Rat Colonic Epithelial K+ Channel KVLQT1 (2001) (75)
- Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin? (2007) (75)
- Characteristics of apical chloride channels in human colon cells (HT29) (1987) (74)
- KVLQT channels are inhibited by the K+ channel blocker 293B (1997) (74)
- The cystic fibrosis transmembrane conductance regulator attenuates the endogenous Ca2+ activated Cl– conductance of Xenopus oocytes (1997) (73)
- CFTR and TMEM16A are Separate but Functionally Related Cl- Channels (2011) (72)
- CFTR-mediated inhibition of epithelial Na+ conductance in human colon is defective in cystic fibrosis. (1999) (71)
- Ion channels in regulated cell death (2016) (70)
- Activation of ion secretion via proteinase-activated receptor-2 in human colon. (2002) (70)
- Control of Cystic Fibrosis Transmembrane Conductance Regulator Expression by BAP31* (2001) (69)
- An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis (2007) (68)
- Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. (2014) (67)
- AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated (2009) (67)
- Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine (2015) (67)
- Cl– Interference with the Epithelial Na+ Channel ENaC* (2005) (66)
- Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents (2013) (64)
- Cl Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA Expression Levels (2008) (64)
- Bicarbonate in cystic fibrosis. (2017) (62)
- Eag1 and Bestrophin 1 Are Up-regulated in Fast-growing Colonic Cancer Cells* (2008) (61)
- Contribution of Anoctamins to Cell Survival and Cell Death (2019) (61)
- TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca(2+) and cell volume. (2015) (61)
- Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice (2010) (60)
- The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. (2014) (60)
- ENaC is inhibited by an increase in the intracellular Cl– concentration mediated through activation of Cl– channels (2002) (60)
- Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator (2000) (59)
- Role of the Ca2+-activated Cl- channels bestrophin and anoctamin in epithelial cells (2011) (59)
- Modulating Ca2+ signals: a common theme for TMEM16, Ist2, and TMC (2016) (59)
- Bestrophin 1 and 2 are components of the Ca(2+) activated Cl(-) conductance in mouse airways. (2008) (58)
- Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes (1997) (57)
- Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. (2002) (57)
- Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells. (1996) (57)
- Correction of the CF defect by curcumin: hypes and disappointments. (2005) (57)
- Protein Traffic Disorders: an Effective High-Throughput Fluorescence Microscopy Pipeline for Drug Discovery (2015) (57)
- Specific blockade of slowly activating IsK channels by chromanols — impact on the role of IsK channels in epithelia (1996) (56)
- Purinergic P2Y6 Receptors Induce Ca2+ and CFTR Dependent Cl- Secretion in Mouse Trachea (2005) (55)
- Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis. (2004) (54)
- TMEM16A is indispensable for basal mucus secretion in airways and intestine (2019) (53)
- Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo. (2018) (53)
- Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A. (2019) (52)
- HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease. (2018) (51)
- TMEM16A in Cystic Fibrosis: Activating or Inhibiting? (2019) (51)
- Escherichia coli α-Hemolysin Triggers Shrinkage of Erythrocytes via KCa3.1 and TMEM16A Channels with Subsequent Phosphatidylserine Exposure* (2010) (51)
- Measurements of CFTR-Mediated Cl− Secretion in Human Rectal Biopsies Constitute a Robust Biomarker for Cystic Fibrosis Diagnosis and Prognosis (2012) (50)
- Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways (2007) (49)
- Mutations in the putative pore‐forming domain of CFTR do not change anion selectivity of the cAMP activated Cl− conductance (1995) (49)
- Niclosamide repurposed for the treatment of inflammatory airway disease. (2019) (49)
- Hypoxia-inducible factor-1α causes renal cyst expansion through calcium-activated chloride secretion. (2014) (49)
- High-Content siRNA Screen Reveals Global ENaC Regulators and Potential Cystic Fibrosis Therapy Targets (2013) (49)
- Na+ and Cl− conductances in airway epithelial cells: increased Na+ conductance in cystic fibrosis (1995) (49)
- Expression and Functional Significance of the Ca2+-Activated Cl- Channel ANO6 in Dendritic Cells (2012) (49)
- KvLQT1 potassium channel but not IsK is the molecular target for trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl- chromane. (1997) (49)
- Properties and regulation of chloride channels in cystic fibrosis and normal airway cells (1989) (48)
- Acute Effects of Parainfluenza Virus on Epithelial Electrolyte Transport* (2004) (47)
- Regulation of the Epithelial Na+ Channel by the Protein Kinase CK2*S⃞ (2008) (47)
- Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity (2011) (47)
- Effects of P‐glycoprotein expression on cyclic AMP and volume‐activated ion fluxes and conductances in HT‐29 colon adenocarcinoma cells (1994) (46)
- Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR‐2) (2005) (46)
- Survival protein anoctamin‐6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage (2016) (45)
- CFTR is activated through stimulation of purinergic P2Y2 receptors (2009) (45)
- Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid (2018) (44)
- Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes (2000) (44)
- Mechanistic Insight into Control of CFTR by AMPK*S⃞ (2009) (44)
- Localization and functional characterization of the human NKCC2 isoforms (2010) (44)
- Phenytoin inhibits necroptosis (2018) (43)
- Cholinergic ion secretion in human colon requires coactivation by cAMP. (1998) (42)
- Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea (2002) (42)
- Regulation and Properties of KCNQ1 (KVLQT1) and Impact of the Cystic Fibrosis Transmembrane Conductance Regulator (2001) (41)
- Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells. (2009) (40)
- Cystic Fibrosis Transmembrane Conductance Regulator Inhibits Epithelial Na+ Channels Carrying Liddle’s Syndrome Mutations* (1999) (40)
- Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia (2006) (40)
- Airway epithelial cells--functional links between CFTR and anoctamin dependent Cl- secretion. (2012) (40)
- Cellular volume regulation by anoctamin 6: Ca2+, phospholipase A2 and osmosensing (2016) (40)
- ADAM10 sheddase activation is controlled by cell membrane asymmetry (2019) (39)
- A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity (2015) (39)
- Simultaneous recording of the cell membrane potential and properties of the cell attached membrane of HT29 colon carcinoma and CF-PAC cells (1991) (39)
- F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis. (2011) (37)
- Regulation of Cl− secretion by AMPK in vivo (2009) (37)
- Control of TMEM16A by INO‐4995 and other inositolphosphates (2013) (36)
- Differential contribution of SLC26A9 to Cl− conductance in polarized and non‐polarized epithelial cells (2012) (36)
- Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis (2016) (36)
- Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling. (2017) (36)
- Non-essential contribution of LRRC8A to volume regulation (2016) (36)
- Cystic fibrosis and CFTR (2001) (36)
- Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo (2020) (35)
- TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice—Brief Report (2016) (35)
- Cl− channels in apoptosis (2016) (35)
- Contribution of TMEM16F to pyroptotic cell death (2018) (35)
- Inhibition of Protein Kinase CK2 Closes the CFTR Cl- Channel, but has no Effect on the Cystic Fibrosis Mutant ΔF508-CFTR (2009) (35)
- Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance regulator (1996) (35)
- Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1* (2015) (34)
- CHLAMYDIA INFECTION (2001) (34)
- Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1. (2018) (34)
- Inhibition of Airway Na+ Transport by Respiratory Syncytial Virus (2007) (33)
- Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4). (2005) (33)
- Small-conductance Cl− channels in HT29 cells: activation by Ca2+, hypotonic cell swelling and 8-Br-cGMP (1992) (33)
- Molecular evolution and functional divergence of the bestrophin protein family (2008) (32)
- Different types of blockers of the intermediate-conductance outwardly rectifying chloride channel in epithelia (1991) (31)
- Amino acid transport in podocytes. (2000) (31)
- Control of Ion Transport in Mouse Proximal and Distal Colon by Prolactin (2007) (30)
- Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H+-ATPase (2013) (29)
- Actin-dependent activation of ion conductances in bronchial epithelial cells (1994) (29)
- Small-conductance chloride channels induced by cAMP, Ca2+, and hypotonicity in HT29 cells: ion selectivity, additivity and stilbene sensitivity (1992) (29)
- ATP-induced Ca2+ signals in bronchial epithelial cells (1998) (28)
- First encounter: how pathogens compromise epithelial transport. (2004) (28)
- APC Sensitive Gastric Acid Secretion (2009) (28)
- Allergen-induced airway hyperresponsiveness is absent in ecto-5′-nucleotidase (CD73)-deficient mice (2008) (27)
- Functional assembly and purinergic activation of bestrophins (2009) (27)
- cAMP-dependent activation of small-conductance Cl− channels in HT29 colon carcinoma cells (1992) (27)
- Ca2+-Induced Cl− Efflux at Rat Distal Colonic Epithelium (2008) (26)
- Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation (2015) (26)
- Proceedings of the Australian Physiological and Pharmacological Society Symposium: Ion Channels EXPRESSION AND FUNCTION OF COLONIC EPITHELIAL KVLQT1 K+ CHANNELS (2001) (26)
- Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A (2020) (26)
- Impaired Renal HCO3 - Excretion in Cystic Fibrosis. (2020) (25)
- Characterization of Novel Airway Submucosal Gland Cell Models for Cystic Fibrosis (2005) (25)
- Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis (2015) (24)
- CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6) (2018) (24)
- Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes. (2001) (24)
- Inhibition of inositol trisphosphate-induced calcium release by cyclic ADP-ribose in A7r5 smooth-muscle cells and in 16HBE14o- bronchial mucosal cells. (1998) (24)
- TMEM16F/Anoctamin 6 in Ferroptotic Cell Death (2019) (24)
- Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility (2013) (24)
- P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells (2016) (24)
- Relationship between TMEM16A/anoctamin 1 and LRRC8A (2016) (23)
- Plasma membrane–localized TMEM16 proteins are indispensable for expression of CFTR (2019) (23)
- Effect of Annexin A5 on CFTR: regulated traffic or scaffolding? (2011) (23)
- Bicarbonate permeability of epithelial chloride channels (1991) (22)
- Ca(2+)- and swelling-induced activation of ion conductances in bronchial epithelial cells. (1994) (22)
- Upregulation of colonic ion channels in APCMin/+ mice (2008) (22)
- The rat Na+–sulfate cotransporter rNaS2: functional characterization, tissue distribution, and gene (slc13a4) structure (2005) (22)
- No evidence for inhibition of ENaC through CFTR-mediated release of ATP. (2002) (22)
- Inhibition of epithelial chloride channels by cytosol (1991) (21)
- Control of Epithelial Ion Transport by Cl− and PDZ Proteins (2004) (21)
- ER localized bestrophin 1 activates Ca 2 + dependent ion channels TMEM 16 A and SK 4 (2009) (21)
- Culture-dependent expression of Na+ conductances in airway epithelial cells (1996) (21)
- Blockade of epithelial Na+ channels by triamterenes — Underlying mechanisms and molecular basis (1996) (20)
- Polycystin-2 Activity Is Controlled by Transcriptional Coactivator with PDZ Binding Motif and PALS1-associated Tight Junction Protein* (2010) (20)
- TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents. (2014) (19)
- N-Acetyl-l-cysteine and its derivatives activate a Cl− conductance in epithelial cells (1996) (19)
- Establishment and Characterization of a Novel Polarized MDCK Epithelial Cellular Model for CFTR Studies (2005) (19)
- Characterization of potassium channels in respiratory cells (1989) (19)
- No Evidence for Direct Activation of the Cystic Fibrosis Transmembrane Conductance Regulator by 8-Cyclopentyl-1,3-Dipropylxanthine (1998) (19)
- Cloning and expression of the mouse glomerular podoplanin homologue gp38P. (2002) (18)
- Airway epithelial cells--hyperabsorption in CF? (2012) (18)
- Anoctamin-6 regulates ADAM sheddase function. (2018) (18)
- Effects of Purinergic Stimulation, CFTR and Osmotic Stress on Amiloride-sensitive Na+ Transport in Epithelia and Xenopus Oocytes (2003) (18)
- A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic. (2018) (18)
- Potassium conductance of smooth muscle cells from rabbit aorta in primary culture (1991) (17)
- Ca2+- and swelling-induced activation of ion conductances in bronchial epithelial cells (1994) (17)
- NCX1 represents an ionic Na+ sensing mechanism in macrophages (2020) (16)
- Pharmacotherapy Of The Ion Transport Defect In Cystic Fibrosis (2001) (16)
- Increase in intracellular Cl− concentration by cAMP- and Ca2+-dependent stimulation of M1 collecting duct cells (2005) (16)
- Getting hands on a drug for Covid-19: Inhaled and Intranasal Niclosamide (2021) (16)
- Characterization of potassium channels in respiratory cells (1989) (16)
- Feedback inhibition of epithelial Na+ channels in Xenopus oocytes does not require G0 or Gi2 proteins (1999) (16)
- Molecular cloning and characterization of the mouse Na+ sulfate cotransporter gene (Slc13a4): Structure and expression. (2006) (16)
- Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site. (2007) (16)
- Functional genomics assays to study CFTR traffic and ENaC function. (2011) (16)
- A Disease-causing Mutation Illuminates the Protein Membrane Topology of the Kidney-expressed Prohibitin Homology (PHB) Domain Protein Podocin* (2014) (15)
- Mechanisms of Chloride Transport in Secretory Epithelia a (1989) (15)
- Glucose promotes secretion-dependent renal cyst growth (2015) (14)
- Regulation of ENaC biogenesis by the stress response protein SERP1 (2012) (14)
- CFTR mutations altering CFTR fragmentation (2012) (14)
- A Bartter’s Syndrome Mutation of ROMK1 Exerts Dominant Negative Effects on K+ Conductance (2000) (14)
- Effects of dietary lectins on ion transport in epithelia (2004) (14)
- Lack of correlation between CFTR expression, CFTR Cl− currents, amiloride‐sensitive Na+ conductance, and cystic fibrosis phenotype (1999) (13)
- IADS, a Decomposition Product of DIDS Activates a Cation Conductance in Xenopus Oocytes and Human Erythrocytes: New Compound for the Diagnosis of Cystic Fibrosis (2006) (13)
- Ion Transport in HT29 Colonic Carcinoma Cells (1993) (13)
- CAMP-dependent activation of ion conductances in bronchial epithelial cells (2004) (13)
- CFTR-mediated inhibition of epithelial Na+ conductance in human colon is defective in cystic fibrosis. (1999) (13)
- GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon (2003) (13)
- Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria. (2018) (13)
- cAMP Stimulation of CFTR-expressing Xenopus oocytes activates a chromanol-inhibitable K+ conductance (1996) (12)
- Expression of anoctamins in retinal pigment epithelium (RPE) (2016) (12)
- Epithelial Chloride Channels (1990) (12)
- Transport properties in CFTR−/− knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption (2020) (12)
- Defects in Processing and Trafficking of Cystic Fibrosis Transmembrane Conductance Regulator (2000) (11)
- TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells (2020) (11)
- TMEM16A Mediated Mucus Production in Human Airway Epithelial Cells. (2020) (10)
- Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins. (2001) (9)
- Oligonucleotide-based gene targeting approaches. (2004) (9)
- P. aeruginosa Induced Lipid Peroxidation Causes Ferroptotic Cell Death in Airways. (2021) (9)
- Electrolyte Transport in the Mouse Trachea: No Evidence for a Contribution of Luminal K+ Conductance (2002) (9)
- KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway (2020) (9)
- Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation (2020) (9)
- Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis (2019) (8)
- Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A > G. (2020) (8)
- Metformin Treatment of Diabetes Mellitus Increases the Risk for Pancreatitis in Patients Bearing the CFTR-mutation S573C (2010) (8)
- Molecular and Functional Characterization of CBAVD-Causing Mutations Located in CFTR Nucleotide-Binding Domains (2008) (8)
- CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca2+-activated Cl- conductance (2011) (8)
- The kappa-opioid receptor agonist asimadoline inhibits epithelial transport in mouse trachea and colon. (2004) (8)
- Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling (2020) (8)
- CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A (2021) (8)
- Characterization of Cytosolic Cl– Channel Inhibitors by Size Exclusion Chromatography (1995) (7)
- The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model (2021) (7)
- TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents (2020) (7)
- Proline‐dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression (2018) (7)
- Control of Ion Transport by Tmem16a Expressed in Murine Intestine (2019) (7)
- The molecular mechanism of CFTR‐ and secretin‐dependent renal bicarbonate excretion (2021) (7)
- Forskolin and PMA pretreatment of HT29 cells alters their chloride conductance induced by cAMP, Ca2+ and hypotonic cell swelling (1994) (7)
- Small and intermediate conductance chloride channels in HT29 cells (1993) (7)
- Regulation and Function of TMEM16F in Renal Podocytes (2018) (6)
- Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the ΔF508 mutation. F508 deletion disrupts a kinase-binding site (Journal of Biological Chemistry (2007) 282, (10804-10813)) (2008) (6)
- Introduction to section V: assessment of CFTR function. (2011) (6)
- Assessment of Distinct Electrophysiological Parameters in Rectal Biopsies for the Choice of the Best Diagnosis/Prognosis Biomarkers for Cystic Fibrosis (2020) (6)
- Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels (2020) (6)
- Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease (2021) (6)
- Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals (2021) (6)
- Cytosolic inhibition and excision activation of epithelial chloride channels. (1991) (5)
- Properties and function of KCNQ1 K+ channels isolated from the rectal gland of Squalus acanthias (2001) (5)
- Chloride secretion, anoctamin 1 and Ca2+ signaling (2014) (5)
- Regulation and amiloride-binding site of epithelial Na+ channels. (1997) (5)
- Methods and resources to understand cystic fibrosis (2011) (4)
- 15 – Epithelial Chloride Channels: Properties and Regulation (1989) (4)
- Loss of PKD1 and PKD2 share common effects on intracellular Ca2+ signaling. (2021) (4)
- Expression of SLC26A9 in Airways and Its Potential Role in Asthma (2022) (4)
- Epithelial cell specific properties and genetic complementation in a ΔF508 cystic fibrosis nasal polyp cell line (1995) (4)
- Cellular volume regulation by anoctamin 6: Ca2+, phospholipase A2 and osmosensing (2015) (4)
- CyFi-MAP: an interactive pathway-based resource for cystic fibrosis (2021) (3)
- GABA, but Not Bestrophin-1, Is Localized in Astroglial Processes in the Mouse Hippocampus and the Cerebellum (2020) (3)
- Systems Approaches to Unravel Molecular Function: High-content siRNA Screen Identifies TMEM16A Traffic Regulators as Potential Drug Targets for Cystic Fibrosis (2022) (3)
- Hypoxia-Inducible Factor-1a Causes Renal Cyst Expansion through Calcium-Activated Chloride (2014) (3)
- Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells (2021) (2)
- Molecular cloning and characterization of the mouse Na + sulfate cotransporter gene ( Slc 13 a 4 ) : structure and expression (2006) (2)
- Control of epithelial Na (2000) (2)
- Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease (2022) (2)
- Role of CFTR and Other Ion Channels in Cystic Fibrosis (2005) (2)
- The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion (2022) (2)
- Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis (2016) (2)
- A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts (2021) (2)
- Contribution of TMEM16F to pyroptotic cell death (2018) (2)
- Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function (2022) (2)
- Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids (2022) (2)
- The Amiloride-inhibitable Na 1 Conductance Is Reduced by the Cystic Fibrosis Transmembrane Conductance Regulator in Normal But Not in Cystic (1998) (2)
- Contents Vol. 8, 2000 (2000) (1)
- Molecular and Cellular Pathobiology TMEM 16 A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression (2012) (1)
- Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? (2013) (1)
- Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels (2022) (1)
- A TMEM16J variant leads to dysregulated cytosolic calcium which may lead to renal disease (2022) (1)
- Approaches to study and correct CFTR defects (2011) (1)
- Ion channels in regulated cell death (2016) (1)
- ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 (2009) (1)
- CFTR-beyond the airways: Recent findings on the role of the CFTR channel in the pancreas, the intestine and the kidneys. (2023) (1)
- Inhibition of Protein Kinase CK 2 Closes the CFTR Cl-Channel , but has no Effect on the Cystic Fibrosis Mutant Δ F 508-CFTR (2009) (1)
- The contribution of CK2 and spleen tyrosine kinase (SYK) to CFTR trafficking and PKA-induced activity. (2011) (1)
- hydrolysis of PIP2 (2004) (1)
- CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6) (2017) (0)
- P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells (2016) (0)
- WS13-3 Electrophysiological measurements in rectal biopsies: a better prognosis biomarker for cystic fibrosis disease? (2019) (0)
- Inhibition of Airway Na (cid:1) Transport by Respiratory Syncytial Virus (cid:1) (2007) (0)
- ATP induced Ca2+ activated Cl− conductance is dependent on VMD2 (bestrophin‐1) expression (2007) (0)
- Plasma membrane–localized TMEM16 proteins are indispensable for expression of CFTR (2019) (0)
- 25* Molecular and functional characterization of CBAVD-causing mutations located in both NBDs of the CFTR protein (2007) (0)
- Relationship between TMEM16A/anoctamin 1 and LRRC8A (2016) (0)
- Cornea Farinata and other Variants (2009) (0)
- Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site. (2007) (0)
- A NEW MODEL OF CF DISEASE: NO F508, NO KINASE? (2008) (0)
- in human colon is defective in cystic fibrosis conductance + CFTR-mediated inhibition of epithelial Na (2016) (0)
- Correction to: Phenytoin inhibits necroptosis (2018) (0)
- SLC26A9 in airways and intestine: secretion or absorption? (2023) (0)
- P204 A check of the organoid FIS assay reproducibility when performed in a newly established local lab (2020) (0)
- Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H+-ATPase (2013) (0)
- Decreased Ca2+-Activated Cl- Secretion in Vmd2-/- Mice (2008) (0)
- Digital Commons@Becker Digital Commons@Becker Epithelial chloride transport by CFTR requires TMEM16A Epithelial chloride transport by CFTR requires TMEM16A (0)
- Epithelial Chloride Transport by CFTR Requires TMEM16A (2017) (0)
- First Encounter: How Pathogens (2004) (0)
- Unexpected effects of pathogens on epithelial Na+ channels. (2000) (0)
- 1 F508del-CFTR increases intracellular Ca 2+ signaling that causes enhanced 2 calcium-dependent Clconductance in cystic fibrosis☆ (2011) (0)
- Correction to: Phenytoin inhibits necroptosis (2018) (0)
- Abstract 1082: The amplification and overexpression of the calcium activated chloride channel TMEM16A (aka DOG1) has a prognostic role in patients with head and neck squamous cell carcinoma (2011) (0)
- Erratum to: AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated (2010) (0)
- Glucose promotes secretion-dependent renal cyst growth (2015) (0)
- Physiological significance and activation of the epithelial calcium-dependent chloride channel TMEM16A (2011) (0)
- Cl− channels in apoptosis (2016) (0)
- Inhibition of epithelial Na+ channels by CFTR and purinergic agonists: Mechanisms and significance for CF (2004) (0)
- Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine (2014) (0)
- Regulation of ENaC biogenesis by the stress response protein SERP1 (2012) (0)
- Subject Index Vol. 8, 2000 (2000) (0)
- Paneth cell secretion in vivo requires expression of Tmem16a and Tmem16f (2022) (0)
- Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling and swelling (2016) (0)
- Erratum: AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated (Pflugers Archiv European Journal of Physiology DOI: 10.1007/s00424-009-0660-4) (2010) (0)
- 400 Novel solute carrier family 26 member 9 inhibitor reveals that solute carrier family 26 member 9 is not the constitutive airway chloride conductance (2022) (0)
- Non-essential contribution of LRRC8A to volume regulation (2016) (0)
- Protein Kinase CK2, Cystic Fibrosis Transmembrane Conductance Regulator, and the ΔF508 Mutation (2007) (0)
- alpha‐hemolysin from E.coli induces P2 receptor activation, shrinkage and phosphatidyl serine exposure in human erythrocytes (2011) (0)
- Title: Benzbromarone for the treatment of cystic fibrosis (CF) lung disease: a pilot clinical trial. (2022) (0)
- 49 Rectal forceps biopsy procedure in cystic fibrosis: Technical aspects and patients' perspective for clinical trials feasibility (2013) (0)
- THE ROLE OF LRRC8A FOR CELLULLAR VOLUME REGULATION AND APOPTOSIS (2016) (0)
- Expression of anoctamins in retinal pigment epithelium (RPE) (2016) (0)
- Modulating Ca2+ signals: a common theme for TMEM16, Ist2, and TMC (2015) (0)
- Phenytoin inhibits necroptosis (2018) (0)
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What Schools Are Affiliated With Karl Kunzelmann?
Karl Kunzelmann is affiliated with the following schools:
