Katalin Karikó
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Hungarian biochemist
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Katalin Karikóbiology Degrees
Biology
#239
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#434
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Biochemistry
#163
World Rank
#211
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Biology
Katalin Karikó's Degrees
- PhD Biochemistry University of Szeged
Why Is Katalin Karikó Influential?
(Suggest an Edit or Addition)According to Wikipedia, Katalin "Kati" Karikó is a Hungarian-American biochemist who specializes in ribonucleic acid -mediated mechanisms, particularly in vitro-transcribed messenger RNA for protein replacement therapy. Karikó laid the scientific groundwork for mRNA vaccines, overcoming major obstacles and skepticism in the scientific community. Karikó received the Nobel Prize in Physiology or Medicine in 2023 for her work, along with American immunologist Drew Weissman.
Katalin Karikó's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. (2005) (1392)
- mRNA-based therapeutics — developing a new class of drugs (2014) (1163)
- COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses (2020) (1143)
- mRNA Is an Endogenous Ligand for Toll-like Receptor 3* (2004) (969)
- Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 (2008) (896)
- Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. (2008) (890)
- Zika virus protection by a single low dose nucleoside modified mRNA vaccination (2017) (624)
- DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration (2011) (566)
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA (2011) (514)
- Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes. (2015) (505)
- Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 31 (2004) (456)
- BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans (2021) (413)
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation (2010) (305)
- Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses (2018) (292)
- Inhibition of Toll-like Receptor and Cytokine Signaling—A Unifying Theme in Ischemic Tolerance (2004) (254)
- Inhibition of HIV-1 Infection by Small Interfering RNA-Mediated RNA Interference1 (2002) (234)
- Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge (2017) (226)
- Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin (2012) (225)
- A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice (2020) (201)
- Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L (2011) (183)
- A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA (2019) (162)
- A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis (2021) (159)
- Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies (2018) (158)
- HIV Gag mRNA Transfection of Dendritic Cells (DC) Delivers Encoded Antigen to MHC Class I and II Molecules, Causes DC Maturation, and Induces a Potent Human In Vitro Primary Immune Response1 (2000) (156)
- BNT162b2 induces SARS-CoV-2-neutralising antibodies and T cells in humans (2020) (154)
- Toll‐like receptor 4 contributes to poor outcome after intracerebral hemorrhage (2011) (150)
- Elimination of large tumors in mice by mRNA-encoded bispecific antibodies (2017) (132)
- Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses (2021) (126)
- Increased radioresistance of ejras‐transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation (1993) (125)
- Cutting Edge: Innate Immune System Discriminates between RNA Containing Bacterial versus Eukaryotic Structural Features That Prime for High-Level IL-12 Secretion by Dendritic Cells1 (2004) (118)
- Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development. (2007) (113)
- HPLC purification of in vitro transcribed long RNA. (2013) (111)
- CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL EFFECTS OF AMPLIGEN, A MISMATCHED DOUBLE-STRANDED RNA, IN PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX (1987) (107)
- Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells. (1990) (106)
- In vitro transcription of long RNA containing modified nucleosides. (2013) (106)
- Rapid method for screening and cloning cDNAs generated in differential mRNA display: application of northern blot for affinity capturing of cDNAs. (1994) (96)
- Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface. (2002) (93)
- Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. (1993) (87)
- Exogenous siRNA Mediates Sequence-Independent Gene Suppression by Signaling through Toll-Like Receptor 3 (2004) (87)
- Concurrent human antibody andTH1 type T-cell responses elicited by a COVID-19 RNA vaccine (2020) (86)
- Characterization of urokinase receptor expression by human placental trophoblasts. (1992) (86)
- Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry. (1996) (83)
- Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA. (1990) (76)
- mRNA: Fulfilling the Promise of Gene Therapy. (2015) (67)
- Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage. (2011) (66)
- gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission. (2007) (66)
- Overexpression of urokinase receptor in mammalian cells following administration of the in vitro transcribed encoding mRNA (1999) (65)
- Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques (2019) (65)
- DICER 1 deficit induces Alu RNA toxicity in age-related macular degeneration (62)
- Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response (2019) (59)
- Short Interfering RNA-Mediated Inhibition of Herpes Simplex Virus Type 1 Gene Expression and Function during Infection of Human Keratinocytes (2004) (59)
- Expression of Urokinase and Its Receptor in Invasive and Non-Invasive Prostate Cancer Cell Lines (1992) (58)
- Phosphate-enhanced transfection of cationic lipid-complexed mRNA and plasmid DNA. (1998) (48)
- The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy. (2019) (47)
- Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease. (1987) (46)
- Extracellular mRNA Induces Dendritic Cell Activation by Stimulating Tumor Necrosis Factor-α Secretion and Signaling through a Nucleotide Receptor* (2002) (44)
- Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways. (1993) (41)
- Phosphorothioate analogues of 2',5'-oligoadenylate. Activation of 2',5'-oligoadenylate-dependent endoribonuclease by 2',5'-phosphorothioate cores and 5'-monophosphates. (1987) (39)
- Effect of Cortical Spreading Depression on the Levels of mRNA Coding for Putative Neuroprotective Proteins in Rat Brain (1998) (38)
- Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine (2022) (36)
- Thermal preconditioning before rat arterial balloon injury: limitation of injury and sustained reduction of intimal thickening. (1998) (35)
- gp340 Expressed on Human Genital Epithelia Binds HIV-1 Envelope Protein and Facilitates Viral Transmission1 (2007) (35)
- Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models (2021) (33)
- Lipofectin‐aided cell delivery of ribozyme targeted to human urokinase receptor mRNA (1994) (32)
- Induction of Tolerance to Focal Ischemia in Rat Brain: Dissociation between Cortical Lesioning and Spreading Depression (2004) (30)
- Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells (1995) (29)
- In vitro-Transcribed mRNA Therapeutics: Out of the Shadows and Into the Spotlight. (2019) (28)
- n-Decyl-NHpppA2'p5'A2'p5'A A phosphatase-resistant, active pppA2'p5'A2'p5'A analog. (1985) (27)
- Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential. (2013) (27)
- Autologous blood injection to model spontaneous intracerebral hemorrhage in mice. (2011) (26)
- Incorporation of [1-14C] acetate into fatty acids of the crustaceansDaphnia magna andCyclops strenus in relation to temperature (1981) (25)
- Publisher Correction: COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses (2021) (25)
- Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor. (1994) (25)
- Oxidative damage of SP‐D abolishes control of eosinophil extracellular DNA trap formation (2018) (23)
- Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatic synthesis, properties, and biological activities of 2',5'-phosphorothioates from adenosine 5'-O-(2-thiotriphosphate) and adenosine 5'-O-(3-thiotriphosphate). (1987) (18)
- Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK (2011) (18)
- Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses (2022) (18)
- Dose-dependent induction of mRNAs encoding brain-derived neurotrophic factor and heat-shock protein-72 after cortical spreading depression in the rat. (2001) (16)
- 2- and 8-azido photoaffinity probes. 1. Enzymatic synthesis, characterization, and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins. (1988) (15)
- Native Atherosclerosis and Vein Graft Arterialization: Association with Increased Urokinase Receptor Expression In Vitro and In Vivo (1998) (14)
- Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema (2021) (14)
- The expression of urokinase-related genes in superficial and invasive transitional cell carcinoma. (1998) (13)
- In vivo protein expression from mRNA delivered into adult rat brain (2001) (13)
- Preconditioning with cortical spreading depression does not upregulate Cu/Zn-SOD or Mn-SOD in the cerebral cortex of rats. (2001) (12)
- Sequence analysis of the 5.34-kb 5' flanking region of the human rhodopsin-encoding gene. (1995) (12)
- Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase. (1991) (11)
- Phosphorothioate Analogs OF 2-5A: Activation / Inhibition of Rnase L and Inhibition of HIV-1 Reverse Transcriftase (1989) (10)
- Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence (2017) (8)
- Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA (2015) (7)
- Urokinase-type plasminogen activator in experimental metastasis of human osteosarcoma cells (1991) (7)
- Invasive neoplastic uroepithelial cells express high-levels of urokinase receptor and plasminogen receptor, alpha-enolase. (1993) (7)
- What does the success of mRNA vaccines tell us about the future of biological therapeutics? (2021) (6)
- A simple device for anticircular thin‐layer chromatography (1979) (6)
- Cerebral preconditioning using cortical application of hypertonic salt solutions: Upregulation of mRNAs encoding inhibitors of inflammation (2006) (6)
- RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia. (1994) (6)
- Abstract LB-130: Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of preclinical cancer models (2018) (5)
- Liposome mediated DNA-transfer into mammalian cells. (1985) (5)
- Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA (2022) (5)
- Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors (2021) (5)
- Transfection of Human Keratinocytes with Nucleoside-Modified mRNA Encoding CPD-Photolyase to Repair DNA Damage. (2016) (4)
- Positive and negative elements mediate control of alternative splicing in the AMPD1 gene. (2000) (4)
- Erratum: Elimination of large tumors in mice by mRNA-encoded bispecific antibodies (2017) (3)
- Phosphorothioate Analogs of 2–5A: Elucidation of the Stereochemical Course of the Enzymes of the 2–5A Synthetase/RNase L System (1987) (3)
- Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies (2018) (3)
- Modified uridines are the key to a successful message (2021) (2)
- Identification of conserved sequences for PCR primer design by multiple alignments of dot matrix plots. (1995) (2)
- Measuring Hematocrit in Mice Injected with In Vitro-Transcribed Erythropoietin mRNA. (2016) (2)
- Cordycepin Analogs of 2–5 a as Activators of RNase L: Study of the Structural Requirements for RNase L Activation (1987) (2)
- Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice (2023) (2)
- Central Tolerance Matters (1)
- Sequence- and target-independent angiogenesissuppressionbysiRNAviaTLR3 (2008) (1)
- Decreased Epstein-Barr virus-induced transformation, and elevated 2-5A synthetase and RNase L activity in peripheral blood mononuclear cells from patients treated with recombinant interferon alfa 2b. (1988) (1)
- COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses (2020) (1)
- Properdin is a pattern recognition molecule for viral double-stranded RNA and contributes to host antiviral innate immune response (2010) (1)
- A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA (2022) (1)
- 550 In vitro delivery of CPD-specific photolyase-encoding mRNA prevents UVB-induced mitochondrial changes (2019) (0)
- Publisher Correction: COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses (2021) (0)
- Erratum: Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: A new approach with future therapeutic potential (Journal of Photochemistry and Photobiology B: Biology (2013) 129 (93-99)) (2014) (0)
- Progress in vaccine development for infectious diseases-a Keystone Symposia report. (2023) (0)
- Bacterial Single-Stranded RNA and Its Structural Mimics Activate High-Level Interleukin-12 Secretion by Human Dendritic Cells (2004) (0)
- In vitro delivery of CPD-specific photolyase-encoding mRNA prevents UVB-induced mitochondrial changes (2019) (0)
- Sustained Reduction of Intimal Thickening Thermal Preconditioning Before Rat Arterial Balloon Injury : Limitation of Injury and Print (1998) (0)
- Cordycepin analogs of 2-5A: activity in rabbit reticulocyte lysates and extracts from L929 cells (1986) (0)
- Expression ofVeryLowDensity Lipoprotein Receptor intheVascular Wall Analysis ofHumanTissues byinSitu Hybridization andImmunohistochemistry (1996) (0)
- 2',5'-8-azidoadenylate trimer 5'-triphosphate (2,5-8-N3p3A3): enzymatic synthesis, biological properties and photoaffinity labelling of RNase L (1987) (0)
- Abstract 3822: Neutrophils and Toll-like receptor 4 Contribute to Injury after Intracerebral Hemorhage (2012) (0)
- Developing mRNA for Therapy. (2022) (0)
- How To Find and Clone the Appropriate cDNA Fragments Generated in Differential mRNA Display by Using Northern Blot for cDNA Capture (1997) (0)
- 620 Poly(ADP-ribose) polymerase-1 activity modulates mitochondrial function following UVB irradiation (2017) (0)
- Toll-like receptor 8 agonist R-848 and IFN-γ synergize for IL-12 production by myeloid DC through expressions of Interferon Consensus Sequence Binding Protein (IRF-8) and Interferon Regulatory Factor-1 (IRF-1) (2005) (0)
- Inhibition of HIV-1 Infection by Small (2002) (0)
- 300 The time-dependency of the cyclobutane pyrimidine dimer-evoked cellular damages using a CPD-specific photolyase-encoding mRNA-based model system (2021) (0)
- Divergent effect of n,n-dimethylformamide on the expression of urokinase and its receptor (1993) (0)
- Honorary Doctorate Dr. Katalin Karikó (2023) (0)
- A small cortical lesion increases the expression of feedback inhibitors of proinflammatory cytokine–signaling (2005) (0)
- Relationship Between EJras Expression And Radiation Resistance In Human Osteosarcoma Cells (1991) (0)
- Impacts of Nucleoside Modi.cation on RNAMediated Activation of Toll-Like Receptors (2008) (0)
- Chiral and achiral phosphorothioate analogs of 2-5A: stereochemical course of RNase L (1986) (0)
- 561 Time-dependence of UVB induced cellular mechanisms in cultured human keratinocytes (2019) (0)
- 540 The role of Poly (ADP-ribose) polymerase-1 in the UVB-driven metabolic changes on HaCaT keratinocytes (2016) (0)
- Cortical spreading depression elevates mRNAs encoding feedback inhibitors of inflammation: A novel mechanism of induced tolerance to ischemia (2005) (0)
- A PCR-Based Approach to Hammerhead Ribozyme Synthesis (1998) (0)
- cell surface endocytic itinerary, resulting in retention of low-density lipoprotein on the Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the (2013) (0)
- 2 and 8-Azido ATP: Photoaffinity Labeling of 2-5A Synthetase, Enzymatic Synthesis of 2 and 8-Azido Anamgs of 2-5A for Use as Photoaffinity Probes of Rnase L (1989) (0)
- Time-dependence of UVB induced cellular mechanisms in cultured human keratinocytes (2019) (0)
- 637 Time-dependent investigation of UVB-induced cellular mechanisms in human keratinocytes using mRNA encoding cyclobutane pyrimidine dimer-specific photolyase (2017) (0)
- This information is current as Dendritic Cells That Prime for High-Level IL-12 Secretion by Bacterial versus Eukaryotic Structural Features Discriminates between RNA Containing Cutting Edge : Innate Immune System (2004) (0)
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