Katerina Akassoglou

Katerina Akassoglou's AcademicInfluence.com Rankings

Katerina Akassoglou

Biology

#13790

World Rank

#17366

Historical Rank

Neuroscience

#2670

World Rank

#2740

Historical Rank

biology Degrees

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Biology

Why Is Katerina Akassoglou Influential?

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According to Wikipedia, Katerina Akassoglou is a neuroimmunologist who is a Senior Investigator and Director of In Vivo Imaging Research at the Gladstone Institutes. Akassoglou holds faculty positions as a Professor of Neurology at the University of California, San Francisco. Akassoglou has pioneered investigations of blood-brain barrier integrity and development of neurological diseases. She found that compromised blood-brain barrier integrity leads to fibrinogen leakage into the brain inducing neurodegeneration. Akassoglou is internationally recognized for her scientific discoveries.

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Katerina Akassoglou's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α (2008) (1265)
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor (2013) (1142)
Fibrinogen as a key regulator of inflammation in disease (2011) (705)
Resolving postoperative neuroinflammation and cognitive decline (2011) (460)
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation (2012) (434)
Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. (1995) (409)
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. (1998) (343)
Chronic optical access through a polished and reinforced thinned skull. (2010) (336)
Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage (2010) (302)
Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke (2011) (299)
The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease (2007) (294)
Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. (1997) (267)
Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics (2018) (230)
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism (2017) (218)
Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation (2015) (205)
TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease. (2000) (193)
Tissue Plasminogen Activator–Mediated Fibrinolysis Protects against Axonal Degeneration and Demyelination after Sciatic Nerve Injury (2000) (182)
Fibrin Inhibits Peripheral Nerve Remyelination by Regulating Schwann Cell Differentiation (2002) (180)
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model (2019) (179)
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. (2004) (158)
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism (2012) (158)
TNF-α transgenic and knockout models of CNS inflammation and degeneration (1997) (151)
Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75NTR (2007) (150)
Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. (2007) (140)
Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation (2012) (133)
Mutant huntingtin impairs immune cell migration in Huntington disease. (2012) (130)
Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. (2004) (126)
Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy (2008) (125)
Fibrin mechanisms and functions in nervous system pathology. (2004) (123)
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration (2018) (120)
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway (2007) (118)
P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. (2005) (114)
Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. (1995) (109)
Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor (2007) (108)
Inhibition of Apoptosis by P2Y2 Receptor Activation: Novel Pathways for Neuronal Survival (2006) (107)
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage (2017) (106)
Systemic inflammation regulates microglial responses to tissue damage in vivo (2014) (106)
Learning abilities, NGF and BDNF brain levels in two lines of TNF-α transgenic mice, one characterized by neurological disorders, the other phenotypically normal (1999) (103)
SIRT1 deacetylates RORγt and enhances Th17 cell generation (2015) (102)
Fibrinogen signal transduction in the nervous system (2009) (96)
Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis (2009) (95)
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation (2020) (89)
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy (2018) (89)
Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia (2017) (83)
Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice (2003) (82)
Early detection of thrombin activity in neuroinflammatory disease (2014) (81)
Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice (2003) (79)
Reduced Mural Cell Coverage and Impaired Vessel Integrity After Angiogenic Stimulation in the Alk1-deficient Brain (2013) (75)
Neurobehavioral Alterations in Developing Transgenic Mice Expressing TNF-α in the Brain (1996) (73)
Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders (2018) (73)
SIRT1 deacetylates RORγt and enhances Th17 cell generation (2015) (71)
Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. (2001) (69)
TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. (1997) (68)
Acute Vascular Disruption and Aquaporin 4 Loss After Stroke (2009) (67)
Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects against Neuroinflammation after Tibia Fracture and Endotoxemia in Mice (2014) (66)
Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α. (2011) (65)
Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity (2017) (63)
Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface (2015) (60)
Chronic imaging and manipulation of cells and vessels through a polished and reinforced thinned-skull (2010) (57)
Nervous System Pathology: The Fibrin Perspective (2002) (56)
Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels (2016) (53)
Microglial Gi-dependent dynamics regulate brain network hyperexcitability (2020) (49)
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity (2012) (42)
In vivo imaging of the mouse spinal cord using two-photon microscopy. (2012) (41)
Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination (2018) (40)
A tumor necrosis factor‐induced model of human primary demyelinating diseases develops in immunodeficient mice (1999) (39)
Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions (2015) (37)
Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling (2020) (36)
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. (2016) (35)
p75 Neurotrophin Receptor Is a Clock Gene That Regulates Oscillatory Components of Circadian and Metabolic Networks (2013) (35)
P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. (2006) (35)
Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy (2017) (31)
Nerve Growth Factor-Independent Neuronal Survival: A Role for NO Donors (2005) (30)
Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain. (1996) (30)
Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease (2017) (28)
Hepatic stellate cells and astrocytes (2011) (27)
Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis (2019) (25)
In Vivo Imaging of CNS Injury and Disease (2017) (25)
Glial expression of tumor necrosis factor in transgenic animals: How do these models reflect the “normal situation”? (2001) (23)
Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1. (2018) (21)
Transgenic models of TNF induced demyelination. (1999) (21)
SIRT 1 deacetylates ROR t and enhances Th 17 cell generation (2015) (18)
Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. (2008) (17)
p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. (2008) (16)
In vivo imaging of the neurovascular unit in CNS disease (2012) (14)
In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target. (2021) (13)
Imaging the dynamic interactions between immune cells and the neurovascular interface in the spinal cord (2019) (13)
Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease,, (2015) (11)
SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy (2021) (11)
Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors. (2007) (10)
Pericytes: The Brain’s Very First Responders? (2018) (10)
BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis (2021) (9)
Coagulation takes center stage in inflammation. (2015) (9)
The immunology of blood: connecting the dots at the neurovascular interface (2020) (7)
778 (2019) (6)
Alzheimer disease makes new blood contacts. (2017) (5)
Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium (2016) (3)
Imaging Microglia in the Central Nervous System: Past, Present and Future (2008) (3)
p75NTR and hypoxia: A breath of fresh air in neurotrophin receptor signaling (2012) (2)
Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation (2016) (2)
ApoE and immunity in Alzheimer’s disease and related tauopathies: Low-density lipoprotein receptor to the rescue (2021) (2)
Coagulation and immunity: Caught in the fibrin web. (2021) (1)
Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma. (2021) (1)
Breaking barriers in postoperative delirium. (2022) (1)
Abstract W P222: Activated Microglia Contribute to Neurovascular Integrity and Limit Brain Injury After Acute Neonatal Focal Stroke (2014) (1)
Imaging of CNS Injury and Disease. (2017) (1)
Radiation in the Wild Multiple Fitness Peaks on the Adaptive Landscape Drive Adaptive (2013) (1)
The immunology of blood: connecting the dots at the neurovascular interface (2020) (1)
Hypoxia Inducible Factor-1 # in Astrocytes-and / or Myeloid Cells is not Required for the Development of Autoimmune Demyelinating Disease Cell-Specific Roles of HIF-1 # in EAE (2015) (1)
Spontaneous inflammatory demyelinating disease intransgenic miceshowingcentral nervoussystem-specific expression oftumornecrosis factor a (autoimmunity/disease model/neuroimmunology/inflammatory/cytokine) (1995) (1)
In vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of fibrinogen deposition in mouse brain (2021) (1)
NGF requirement for neuronal survival? NO thanks! (2005) (1)
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration (2018) (1)
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation (2020) (1)
The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum (2022) (1)
Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer's Disease. (2023) (1)
Glucose homeostasis and p75NTR (2012) (1)
Growth factors and genetic modifiers in vascular biology and cancer Program : Developmental and Stem Cell Biology (2017) (0)
Regulatory role of TNF in experimental ocular inflammation (1998) (0)
ID: 075 Fibrin deposition and axonal damage in spinal cord injury (2006) (0)
ID: 071 Fibrin/Mac-1 interactions induce microglia activation and regulate relapsing paralysis in central nervous system autoimmune disease (2006) (0)
Phospholipase C‐epsilon Mediates Inflammatory Responses in Experimental Autoimmune Encephalomyelitis Progression through its Role in Astrocyte GPCR Signaling (2016) (0)
ENDOTHELIAL-DERIVED EXOSOME BIOMARKERS SUGGEST ACTIVATION OF INNATE IMMUNITY IN SUBCLINICAL CEREBROVASCULAR DISEASE (2018) (0)
Functional interactions between the p75 neurotrophin receptor and phosphodiesterases (2007) (0)
Microglia (2020) (0)
Interaction Between Fibrinogen and the Microglial CD11b Receptor Mediates Several Neuropathological Alterations in a Mouse Model of Alzheimer's Disease (2019) (0)
Fibrinogen as a contributor and therapeutic target in neuroinflammatory disease (2013) (0)
Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis (2023) (0)
778: BBB DISRUPTION AFTER CORTICAL IMPACT A ROLE FOR FIBRIN IN POST-TBI NEUROINFLAMMATION? (2019) (0)
Local TNF ligand/receptor signaling induces MS-type plaques in the CNS of transgenic mice (1998) (0)
Acknowledgement of Reviewers 2014 (2015) (0)
ID: 64 Loss of p75 neurotrophin receptor exacerbates the effects of plasminogen deficiency (2006) (0)
Chapter 41 – Microglia (2013) (0)
Cellular Dynamics of Allergic Immune Responses " Projects : Allergy and Asthma , Immune Regulation , Immune Receptors and Signaling , and Inflammation (2006) (0)
220: Fibrinogen/CR3 signaling induces demyelination by promoting Th1 cell differentiation and peripheral macrophage recruitment into the CNS (2013) (0)
ASTROGLIAL AND MICROGLIAL MODULATION OF NEURAL FUNCTIONS IN MODELS OF ALZHEIMER’S DISEASE (2019) (0)
Reduction of Prothrombin in Mice Carrying a Conditional Knockout Allele Attenuates the Development of Paralysis Associated with Experimental Encephalitis. (2007) (0)
BIOMARKERS SUGGESTACTIVATION OF INNATE IMMUNITY IN SUBCLINICAL CEREBROVASCULAR DISEASE (2018) (0)
Microglial Gi-dependent dynamics regulate brain network hyperexcitability (2020) (0)
The role of Rho GTPases in astrocyte polarity and migration after injury (2007) (0)
84 P75 neurotrophin receptor promotes liver regeneration via regulation of hepatic stellate cell differentiation (2006) (0)
Author Correction: The immunology of blood: connecting the dots at the neurovascular interface (2020) (0)
Acknowledgment to reviewers 2018 (2018) (0)
X-ray structure of Lfa-1 I domain in complex with BMS-68852 collected at 273 K (2021) (0)
The TNF/TNF receptor system in CNS Disease: Studies in transgenic and mutant mice (1998) (0)
Blood‐brain barrier dysfunction is associated with A/T/N biomarkers and cognition in the aging brain (2022) (0)
Role for TNF in CNS Inflammation, Demyelination and Neurodegeneration Studied in Transgenic Mice (1998) (0)
ID: 248 p75 Neurotrophin Receptor Regulates Fibrinolysis via a cAMP/PKA Pathway (2006) (0)
Neurovascular interactions: Mechanisms, imaging, and therapeutics (2019) (0)
X-ray structure of Lfa-1 I domain collected at 273 K (2021) (0)
Fibrinogen as a key regulator of inflammation in disease (2011) (0)
X-ray structure of Lfa-1 I domain in complex with Lovastatin collected at 273 K (2021) (0)
TNF-triggered CNS inflammation, demyelination and T cell autoreactivity in transgenic mice: A role for mature lymphocytes in disease modulation but not disease initiation (1997) (0)
Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling (2020) (0)
Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation (2020) (0)
Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment (2021) (0)
Neurovascular Interactions: Mechanisms, Imaging, Therapeutics (2022) (0)

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What Schools Are Affiliated With Katerina Akassoglou?

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