Katherine Borden
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Katherine Borden's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science Stanford University
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Why Is Katherine Borden Influential?
(Suggest an Edit or Addition)According to Wikipedia, Katherine Borden PhD FRSC is a researcher of Molecular Biology at the University of Montreal in Quebec, Canada. She has worked on finding new cancer treatments using pre-existing drugs, and was inducted as a fellow of the Royal Society of Canada in 2022.
Katherine Borden's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Does this have a familiar RING? (1996) (628)
- Mechanisms and insights into drug resistance in cancer (2013) (502)
- The RING finger domain: a recent example of a sequence-structure family. (1996) (495)
- RING domains: master builders of molecular scaffolds? (2000) (431)
- The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto‐oncoprotein PML. (1995) (345)
- Identification and preliminary characterization of a protein motif related to the zinc finger. (1993) (342)
- Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies (2002) (325)
- Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap (2004) (273)
- eIF4E is a central node of an RNA regulon that governs cellular proliferation (2006) (269)
- Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. (2009) (266)
- RING fingers and B-boxes: zinc-binding protein-protein interaction domains. (1998) (251)
- Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities (2004) (247)
- MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. (2012) (213)
- The Mdm2 RING domain C‐terminus is required for supramolecular assembly and ubiquitin ligase activity (2007) (204)
- Aberrant Eukaryotic Translation Initiation Factor 4E-Dependent mRNA Transport Impedes Hematopoietic Differentiation and Contributes to Leukemogenesis (2003) (189)
- In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions (2000) (189)
- Solution structure of the PHD domain from the KAP‐1 corepressor: structural determinants for PHD, RING and LIM zinc‐binding domains (2001) (187)
- PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA (2001) (182)
- eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR (2005) (179)
- PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. (2008) (178)
- An Arenavirus RING (Zinc-Binding) Protein Binds the Oncoprotein Promyelocyte Leukemia Protein (PML) and Relocates PML Nuclear Bodies to the Cytoplasm (1998) (169)
- The proline‐rich homeodomain protein, PRH, is a tissue‐specific inhibitor of eIF4E‐dependent cyclin D1 mRNA transport and growth (2003) (163)
- The sonic hedgehog factor Gli1 imparts drug resistance through inducible glucuronidation (2014) (159)
- Controlling Gene Expression through RNA Regulons: The Role of the Eukaryotic Translation Initiation Factor eIF4E (2007) (158)
- Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. (2013) (154)
- The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. (2001) (145)
- Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export‐competent RNP (2009) (132)
- The emerging roles of translation factor eIF4E in the nucleus. (2002) (123)
- Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. (1997) (115)
- In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML. (1996) (114)
- Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer (2011) (114)
- The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner (2000) (114)
- Two RING Finger Proteins, the Oncoprotein PML and the Arenavirus Z Protein, Colocalize with the Nuclear Fraction of the Ribosomal P Proteins (1998) (112)
- The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation. (2012) (112)
- Control of biochemical reactions through supramolecular RING domain self-assembly (2002) (110)
- Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? (2010) (108)
- The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA (2000) (102)
- Self-assembly properties of a model RING domain (2002) (102)
- Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING. (2004) (102)
- Eukaryotic Translation Initiation Factor 4E Activity Is Modulated by HOXA9 at Multiple Levels (2005) (102)
- Cap‐free structure of eIF4E suggests a basis for conformational regulation by its ligands (2006) (100)
- Regulation of p53 Localization and Activity by Ubc13 (2006) (100)
- The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger. (1994) (99)
- Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. (1998) (96)
- mRNA export and cancer (2012) (90)
- Role of the Promyelocytic Leukemia Protein PML in the Interferon Sensitivity of Lymphocytic Choriomeningitis Virus (2001) (89)
- The eIF4E RNA regulon promotes the Akt signaling pathway (2008) (88)
- Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer (2008) (88)
- eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition (2013) (86)
- Further evidence that ribavirin interacts with eIF4E. (2005) (86)
- The oncogene eIF4E: using biochemical insights to target cancer. (2013) (83)
- The promyelocytic leukemia protein PML has a pro‐apoptotic activity mediated through its RING domain (1997) (79)
- Novel topology of a zinc‐binding domain from a protein involved in regulating early Xenopus development. (1995) (77)
- Activation Loop Phosphorylation of ERK3/ERK4 by Group I p21-activated Kinases (PAKs) Defines a Novel PAK-ERK3/4-MAPK-activated Protein Kinase 5 Signaling Pathway* (2010) (74)
- Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E (2010) (72)
- MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL (2014) (71)
- Two Fundamentally Distinct PCNA Interaction Peptides Contribute to Chromatin Assembly Factor 1 Function (2009) (71)
- A TFEB nuclear export signal integrates amino acid supply and glucose availability (2018) (71)
- Aiding and abetting cancer: mRNA export and the nuclear pore. (2013) (69)
- Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas. (2016) (68)
- The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control (1999) (66)
- A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E (2015) (60)
- RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth (2013) (59)
- Gamma Interferon and Cadmium Treatments Modulate Eukaryotic Initiation Factor 4E-Dependent mRNA Transport of Cyclin D1 in a PML-Dependent Manner (2002) (59)
- Multiple Export Mechanisms for mRNAs (2015) (59)
- Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer (2009) (57)
- UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML (2003) (57)
- Homeodomain proteins and eukaryotic translation initiation factor 4E (eIF4E): an unexpected relationship. (2005) (57)
- A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery. (2017) (55)
- The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled (2015) (54)
- Characterisation of a novel cysteine/histidine‐rich metal binding domain from Xenopus nuclear factor XNF7 (1993) (50)
- Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E. (2012) (48)
- Ribavirin targets eIF4E dependent Akt survival signaling. (2008) (47)
- Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase. (1998) (47)
- Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds. (2006) (47)
- Physical mechanisms and biological significance of supramolecular protein self-assembly. (2004) (47)
- Control of p53 multimerization by Ubc13 is JNK-regulated (2009) (46)
- BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export (2018) (44)
- Conformational properties of the G.G mismatch in d(CGCGAATTGGCG)2 determined by NMR. (1992) (40)
- Surface residue mutations of the PML RING finger domain alter the formation of nuclear matrix-associated PML bodies. (1997) (39)
- The eukaryotic translation initiation factor eIF4E wears a “cap” for many occasions (2016) (36)
- Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E (2016) (34)
- Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation (2019) (32)
- Construction of macromolecular assemblages in eukaryotic processes and their role in human disease: linking RINGs together. (2000) (31)
- Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon? (2008) (31)
- The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus (2005) (30)
- SOLUTION STRUCTURE OF THE PHD DOMAIN FROM THE KAP-1 COREPRESSOR (2001) (30)
- Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate. (2013) (26)
- The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain. (2007) (26)
- The eukaryotic translation initiation factor 4E (eIF4E) and HuR RNA operons collaboratively regulate the expression of survival and proliferative genes (2009) (25)
- An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein. (2010) (24)
- Perspectives in PML: a unifying framework for PML function. (2009) (24)
- LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. (2014) (23)
- eIF4E3, a new actor in mRNA metabolism and tumor suppression (2013) (22)
- Targeting the oncogene eIF4E in cancer: From the bench to clinical trials. (2011) (22)
- The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery (2020) (22)
- Structure/function in neuroprotection and apoptosis (1998) (21)
- Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia (2018) (20)
- The Yeast Two-hybrid System and Its Pharmaceutical Significance (2000) (19)
- The Impact of Post-transcriptional Control: Better Living Through RNA Regulons (2018) (18)
- The Nuclear Pore Complex and mRNA Export in Cancer (2020) (18)
- Nuclear eIF4E Stimulates 3′-End Cleavage of Target RNAs (2019) (17)
- Molecular Pathways: GLI1-Induced Drug Glucuronidation in Resistant Cancer Cells (2015) (16)
- NMR assignment of the arenaviral protein Z from Lassa fever virus (2008) (15)
- Determination of the orientations of tryptophan analogues bound to the trp repressor and the relationship to activation. (1991) (15)
- Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes. (2019) (14)
- The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts (2020) (14)
- Folding kinetics of phage T4 thioredoxin. (1990) (13)
- Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E. (2019) (12)
- The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity (2017) (11)
- GLI1-Inducible Glucuronidation Targets a Broad Spectrum of Drugs. (2019) (9)
- The Development of Novel Therapies for the Treatment of Acute Myeloid Leukemia (AML) (2012) (9)
- Sequence-specific NMR assignments of the trp repressor from Escherichia coli using three-dimensional 15N/1H heteronuclear techniques. (1992) (8)
- The activating transcription factor region within the E2A promoter exists in a novel conformation. (1993) (8)
- Promyelocytic leukemia protein (2012) (7)
- Puzzled by PML (2010) (5)
- When will resistance be futile? (2014) (5)
- A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH (2009) (5)
- The eIF 4 E RNA regulon promotes the Akt signaling pathway (2008) (4)
- Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y (2018) (4)
- The Eukaryotic Translation Initiation Factor 4E (eIF4E) Has Oncogenic Functions and May Represent a New Therapeutic Target In Diffuse Large B Cell Lymphoma (DLBCL) (2013) (4)
- The Cap-Binding Complex CBC and the Eukaryotic Translation Factor eIF4E: Co-Conspirators in Cap-Dependent RNA Maturation and Translation (2021) (4)
- NMR assignment of human eukaryotic translation initiation factor 4E (eIF4E) in its cap-free form (2006) (3)
- The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery and drives alternative splicing (2021) (3)
- Solution Structure of the C-terminal RING from a RING-IBR-RING (TRIAD) motif (2004) (3)
- A Phase I Combination Study of Ribavirin and Low Dose Cytarabine Arabinoside (ara-C) in M4/M5 Acute Myeloid Leukemia (AML) and AML with High eIF4E, (2011) (3)
- Folding of the reduced form of the thioredoxin from bacteriophage T4. (1990) (3)
- Targeting the Oncogene eIF4E with Ribavirin: A Novel Therapeutic Avenue in Acute Myeloid Leukemia. (2009) (3)
- Subcellular Fractionation Suitable for Studies of RNA and Protein Trafficking. (2022) (2)
- CDK9 and mTOR: trading places. (2019) (2)
- Two mutant binding sites of the activating transcription factor region within the E2A promoter of adenovirus exist in a novel conformation. (1994) (2)
- Backbone assignment of the apo-form of the human C-terminal domain of UDP-glucuronosyltransferase 1A (UGT1A) (2018) (2)
- Chemosensitization of Diffuse Large B Cell Lymphoma by Demethylating Nucleoside Analogues (2011) (2)
- Unorthodox PCNA Binding by Chromatin Assembly Factor 1 (2022) (2)
- mRNA Export and Its Dysregulation in Disease (2018) (1)
- Tissue Targeting in Cancer: eIF4E's Tale (2009) (1)
- NMR solution structure of LFV-Z (2010) (1)
- 1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C) (2021) (1)
- A TFEB nuclear export signal integrates amino acid supply and glucose availability (2018) (1)
- Ribavirin, an eIF4E Inhibitor, As a Potential Anti-Lymphoma Therapeutic - Preclinical and Early Clinical Data (2016) (1)
- Cancer cells hijack RNA processing to rewrite the message (2022) (1)
- Preface [Hot Topic: Supermolecular Machines and Assemblies (Guest Editors: Katherine L.B. Borden & Paul S. Freemont)] (2004) (0)
- Inducible drug modification: A new form of resistance (2014) (0)
- Sonic Hedgehog factor Gli1: As good as resistant (2015) (0)
- Solution structure of LIMD2 (2014) (0)
- Abstract B12: EIF4E deregulation drives simultaneous expression of B-cell lymphoma oncogenes. (2015) (0)
- Transcriptional Functions Residues Required for Biological and BTB / POZ Domain Reveals Motifs and Promyelocytic Leukemia Zinc Finger In-Depth Mutational Analysis of the (2000) (0)
- TRANSCRIPTION FACTOR PML, A PROTO-ONCOPROTEIN, NMR, 1 REPRESENTATIVE STRUCTURE AT PH 7.5, 30 C, IN THE PRESENCE OF ZINC (1997) (0)
- Solution structure of eIF4E3 in complex with m7GDP (2013) (0)
- The eukaryotic translation initiation factor eIF4E reprograms alternative splicing (2023) (0)
- TissueTargeting in Cancer : eIF 4 E ’ sTale 55 Commentary on Ko et al . , p . 4336 (2009) (0)
- TIF-90 tips the balance in rRNA synthesis. (2014) (0)
- Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor 4E refractory/relapsed acute myeloid leukemia patients: a randomized phase II trial of vismodegib, ribavirin with or without decitabine. (2023) (0)
- The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety (2013) (0)
- Invivoandinvitro characterization oftheBiandB2 zinc-binding domainsfromtheacutepromyelocytic leukemia protooncoprotein PML (1996) (0)
- Crystal structure of the cap free human translation initiation factor eIF4E (2011) (0)
- The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus (2008) (0)
- The Eukaryotic Translation Initiation Factor eIF4E, a Recently Identified Therapeutic Target In AML, Is a Direct Transcriptional Target of NFkB (2010) (0)
- Abstract B08: eIF4E3 forms a novel cap-binding complex for mRNA translation initiation. (2015) (0)
- Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y (2018) (0)
- Author response: The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity (2017) (0)
- Inhibition of Different Lassa Virus Strains by Alpha and Gamma Interferons and Comparison with a Less Pathogenic Arenavirus (2004) (0)
- Cap-free structure of eIF4E suggests basis for its allosteric regulation (2006) (0)
- Abstract 3165: Anti-tumor activity of the eIF4E-targeted drug ribavirin in breast cancer cells (2010) (0)
- Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase (2014) (0)
- Crystal structure of the human eIF4E-4EBP1 peptide complex without cap (2011) (0)
- XNF7 BBOX, DEVELOPMENTAL PROTEIN, PH 7.5, 30 C, WITH ZINC, NMR, 1 STRUCTURE (1997) (0)
- The search for genetic dark matter and lessons learned from the journey. (2022) (0)
- EIF 4 E ( eukaryotic translation initiation factor 4 E ) (2012) (0)
- Abstract A19: MALT1 inhibition as an anchor for combinatorial therapy of ABC-DLBCL. (2015) (0)
- A New Form Of Therapeutic Resistance: Drug Glucuronidation Regulated By The Sonic Hedgehog Factor Gli1 (2013) (0)
- Abstract 2693: Harnessing MALT1 inhibition for rational combinatorial therapy of ABC-DLBCL (2014) (0)
- Molecular and Cellular Pathobiology LIMD 2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase (2014) (0)
- 1H, 13C, 15N Backbone and sidechain chemical shift assignments of the C-terminal domain of human UDP-glucuronosyltransferase 2B17 (UGT2B17-C) (2023) (0)
- Backbone assignment of the apo-form of the human C-terminal domain of UDP-glucuronosyltransferase 1A (UGT1A) (2018) (0)
- Molecular Pathways : GLI 1-Induced Drug Glucuronidation in Resistant Cancer Cells (2015) (0)
- eIF4E and post-transcriptional gene regulation in cancer (2008) (0)
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