Katherine Seley-Radtke
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Katherine Seley-Radtkechemistry Degrees
Chemistry
#5469
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#6655
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Organic Chemistry
#1078
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#1217
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Chemistry
Katherine Seley-Radtke's Degrees
- PhD Chemistry University of Maryland, Baltimore County
Why Is Katherine Seley-Radtke Influential?
(Suggest an Edit or Addition)According to Wikipedia, Katherine Seley-Radtke is an American medicinal chemist who specializes in the discovery and design of novel nucleoside or nucleotide based enzyme inhibitors that may be used to treat infections or cancer. She has authored over 90 peer-reviewed publications,is an inventor of five issued US patents, and is a professor in the department of chemistry and biochemistry at the University of Maryland, Baltimore County. Her international impact includes scientific collaborations, policy advising and diplomatic appointments in biosecurity efforts.
Katherine Seley-Radtke's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold (2018) (263)
- The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold (2018) (127)
- Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses (2018) (95)
- Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity (2015) (68)
- 1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents (2011) (39)
- Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides (2018) (34)
- Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines. (2014) (28)
- N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase (2013) (25)
- Thiophene-expanded guanosine analogues of Gemcitabine. (2015) (25)
- Flex-nucleoside analogues – Novel therapeutics against filoviruses (2017) (24)
- NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1. (2011) (22)
- “Reverse” Carbocyclic Fleximers: Synthesis of a New Class of Adenosine Deaminase Inhibitors (2013) (21)
- Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides. (2015) (20)
- 1-Benzyl derivatives of 5-(arylamino)uracils as anti-HIV-1 and anti-EBV agents. (2010) (19)
- Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics. (2010) (19)
- Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof (2013) (18)
- Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase. (2006) (17)
- Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues. (2012) (16)
- Synthetic Routes to a Series of Proximal and Distal 2′-Deoxy Fleximers (2012) (15)
- Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity. (2011) (15)
- Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies. (2015) (13)
- Novel 5′-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents (2018) (13)
- Mechanistic studies in the synthesis of a series of thieno-expanded xanthosine and guanosine nucleosides. (2008) (13)
- 5‐Arylaminouracil Derivatives: New Inhibitors of Mycobacterium tuberculosis (2015) (13)
- Evaluation of the antiprotozoan properties of 5'-norcarbocyclic pyrimidine nucleosides. (2017) (13)
- Flexibility as a Strategy in Nucleoside Antiviral Drug Design. (2015) (12)
- Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs. (2015) (12)
- A Computational Study of Expanded Heterocyclic Nucleosides in DNA (2008) (12)
- Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro (2020) (12)
- Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents (2019) (11)
- Design and Synthesis of a Series of Truncated Neplanocin Fleximers (2014) (11)
- Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides. (2009) (11)
- Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines. (2015) (11)
- Structure-activity evaluation of new uracil-based non-nucleoside inhibitors of HIV reverse transcriptase (2013) (10)
- Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity (2019) (10)
- Mitotic arrest of breast cancer MDA-MB-231 cells by a halogenated thieno[3,2-d]pyrimidine. (2015) (9)
- Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology. (2013) (9)
- Hetero-expanded purine nucleosides. Design, synthesis and preliminary biological activity. (2008) (9)
- Broad-Spectrum Antiviral Activity of 3′-Deoxy-3′-Fluoroadenosine against Emerging Flaviviruses (2020) (9)
- 5′-Nor carbocyclic nucleosides: unusual nonnucleoside inhibitors of HIV-1 reverse transcriptase (2013) (9)
- An Efficient Route to Novel Uracil-Based Drug-Like Molecules (2015) (9)
- A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides (2012) (8)
- Meeting report: 32nd International Conference on Antiviral Research (2013) (8)
- "Reverse fleximers": introduction of a series of 5-substituted carbocyclic uridine analogues. (2008) (8)
- Flexibility—Not just for yoga anymore! (2018) (7)
- Synthesis of 3-hetarylpyrroles by Suzuki–Miyaura cross-coupling (2020) (7)
- Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1 (2019) (7)
- Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics (2019) (7)
- 1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus. (2016) (6)
- Broad spectrum antiviral nucleosides—Our best hope for the future (2021) (6)
- Novel 1-[5-(4-bromophenoxy)pentyl]-3-(2-arylamino- 2-oxoethyl)uracils and their antiviral properties (2017) (6)
- Anticancer Properties of Halogenated Pyrrolo[3,2‐d]pyrimidines with Decreased Toxicity via N5 Substitution (2018) (6)
- An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases (2020) (6)
- Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides (2015) (6)
- Modified Synthesis of 3′-OTBDPS-Protected Furanoid Glycal (2012) (5)
- Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides (2020) (5)
- Synthesis and antiviral evaluation against the Vaccinia virus of new N1-oxide analogs of 5′-noraristeromycin (2010) (3)
- Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis. (2021) (3)
- Synthetic Approaches to the Fleximer Class of Nucleosides - A Historic Perspective (2018) (3)
- Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase. (2006) (2)
- Carbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents (2009) (2)
- A Carbocyclic 7-Deazapurine-Pyrimidine Hybrid Nucleoside (2006) (2)
- Advances in antiviral nucleoside analogues and their prodrugs (2018) (2)
- Flexible Nucleobase Analogues: Novel Tools for Exploring Nucleic Acids (2014) (2)
- Synthesis of a Series of 2′-Modified Tricyclic Nucleosides as Potential HCV Agents (2010) (2)
- New directions in the experimental therapy of tick-borne encephalitis. (2022) (2)
- “Reverse” Carbocyclic Fleximers: Synthesis of a New Class of Adenosine Deaminase Inhibitors. (2013) (1)
- A Carbocyclic 7‐Deazapurine‐pyrimidine Hybrid Nucleoside (2007) (1)
- [Synthesis and antiviral evaluation against Vaccinia virus of new N¹-oxide analogues of 5'-noraristeromycin]. (2010) (1)
- Meeting report: 34th international conference on antiviral research (2022) (1)
- Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase (2022) (1)
- Synthesis and Antiviral Activity of Substituted Uracils (2009) (1)
- antiviral evaluation against Vaccinia virus of new N-oxide analogues of 5'-noraristeromycin]. Matiugina E S, Seley-Radtke K L, Andronova V L (2010) (1)
- The Twenty-Second International Conference on Antiviral Research (2009) (1)
- Small molecule antivirals – Still our best hope for a cure (2020) (0)
- The Organic Chemistry of Drug Synthesis, Volume 7 By Daniel Lednicer (North Bethesda, MD). John Wiley & Sons, Inc.: Hoboken, NJ. 2007. xiv + 272 pp. $115.00. ISBN 978-0-470-10750-8. (2008) (0)
- Comparison of the Old and New - Novel Mechanisms of Action for Anti-coronavirus Nucleoside Analogues (2022) (0)
- NMR STUDIES REVEAL UNEXPECTED BINDING SITE FOR APE1 REDOX INHIBITOR (2011) (0)
- A Highly Facile Approach to the Synthesis of Novel 2-(3-Benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl) -N-phenylacetamides. (2013) (0)
- Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP (2023) (0)
- Meeting report: 35th international conference on antiviral research in Seattle, WA, USA – March 21–25, 2022 (2022) (0)
- Cover Feature: An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases (ChemBioChem 10/2020) (2020) (0)
- Preface (2021) (0)
- A Small Trial Finds that Hydroxychloroquine Is Not Effective for Treating Coronavirus (2020) (0)
- Corrigendum (2016) (0)
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