Kathleen Giacomini
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American pharmaceutical bioengineer
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Kathleen Giacominiengineering Degrees
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Bioengineering
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#35
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#11
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Engineering
Kathleen Giacomini's Degrees
- PhD Pharmaceutical Sciences University of California, San Francisco
- Bachelors Pharmacy University of California, San Francisco
Why Is Kathleen Giacomini Influential?
(Suggest an Edit or Addition)According to Wikipedia, Kathleen M. Giacomini is a professor of bioengineering and therapeutic sciences at the University of California, San Francisco. Her work focuses on how genetics affects the efficacy of drugs. She is also the co-director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation for the department of Bioengineering at the University of California, San Francisco.
Kathleen Giacomini's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Membrane transporters in drug development (2010) (2882)
- Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. (2007) (878)
- SLC transporters as therapeutic targets: emerging opportunities (2015) (505)
- The concentrative nucleoside transporter family, SLC28 (2004) (427)
- Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. (2003) (424)
- Cloning and functional expression of a human liver organic cation transporter. (1997) (403)
- Organic cation transporters are determinants of oxaliplatin cytotoxicity. (2006) (386)
- Metformin pathways: pharmacokinetics and pharmacodynamics (2012) (365)
- Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. (2009) (321)
- Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges (2007) (286)
- Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 (2003) (285)
- Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. (2001) (275)
- Renal transporters in drug development. (2013) (255)
- Natural variation in human membrane transporter genes reveals evolutionary and functional constraints (2003) (236)
- Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. (2012) (234)
- Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin (2009) (233)
- When good drugs go bad (2007) (233)
- cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects (2008) (202)
- Role of organic cation transporters in drug absorption and elimination. (1998) (201)
- Genetics of P450 oxidoreductase: Sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations (2008) (197)
- Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. (2002) (196)
- OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin (2014) (188)
- Interaction of Methotrexate with Organic-Anion Transporting Polypeptide 1A2 and Its Genetic Variants (2006) (184)
- Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin (2010) (183)
- Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins (2011) (175)
- Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). (1998) (172)
- Pharmacogenomics: Challenges and Opportunities (2006) (162)
- Role of the Copper Transporter, CTR1, in Platinum-Induced Ototoxicity (2010) (152)
- Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance (2018) (152)
- Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1 (2013) (148)
- Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes (2001) (146)
- Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. (2011) (141)
- Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (1997) (140)
- Variation in the Glucose Transporter gene SLC2A2 is associated with glycaemic response to metformin (2016) (139)
- Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. (2006) (128)
- The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene (2008) (123)
- PharmGKB summary: methotrexate pathway. (2011) (117)
- Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. (2013) (117)
- Metformin Pharmacogenomics: Current Status and Future Directions (2014) (115)
- Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug‐Drug Interaction Evaluation: Perspectives From the International Transporter Consortium (2018) (113)
- Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET (2011) (112)
- Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase (2010) (111)
- Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP (2008) (109)
- Comparison of human solute carriers (2010) (107)
- Profiling Solute Carrier Transporters in the Human Blood-Brain Barrier (2013) (107)
- Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). (2000) (105)
- Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. (1992) (104)
- Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function (2009) (100)
- A genome-wide association study of bronchodilator response in Latinos implicates rare variants. (2014) (100)
- Transport of Paraquat by Human Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Family (2007) (98)
- Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1) (2005) (98)
- The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. (2006) (95)
- A Genome-Wide Association Study of Overall Survival in Pancreatic Cancer Patients Treated with Gemcitabine in CALGB 80303 (2011) (94)
- Interactions of n-Tetraalkylammonium Compounds and Biguanides with a Human Renal Organic Cation Transporter (hOCT2) (2002) (91)
- Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. (2001) (91)
- Transporters Involved in Metformin Pharmacokinetics and Treatment Response. (2017) (89)
- The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1. (1999) (88)
- Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin (2015) (87)
- Stereoselective renal clearance of pindolol in humans. (1985) (86)
- Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. (2004) (86)
- Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. (2000) (84)
- Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium (2018) (83)
- Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. (2003) (82)
- Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges (2008) (82)
- Novel variants in human Aquaporin-4 reduce cellular water permeability. (2008) (81)
- Genetic Polymorphisms in Organic Cation Transporter 1 (OCT1) in Chinese and Japanese Populations Exhibit Altered Function (2010) (80)
- Consequences of POR mutations and polymorphisms (2011) (78)
- Amitriptyline disposition in young and elderly normal men (1983) (78)
- Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. (2003) (78)
- Molecular modeling and ligand docking for solute carrier (SLC) transporters. (2013) (77)
- Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions (2011) (75)
- Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations (2014) (75)
- Genetic and Epigenetic Regulation of the Organic Cation Transporter 3, SLC22A3 (2011) (74)
- Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3. (2016) (73)
- Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. (1993) (73)
- Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1. (2003) (72)
- Molecular cloning and functional expression of a rabbit renal organic cation transporter. (1998) (72)
- Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). (2015) (72)
- Organic Cation Transporters Modulate the Uptake and Cytotoxicity of Picoplatin, a Third-Generation Platinum Analogue (2010) (71)
- Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine (2016) (71)
- Cloning and Functional Characterization of a Rat Renal Organic Cation Transporter Isoform (rOCT1A)* (1997) (70)
- Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro (2010) (69)
- Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3. (2001) (68)
- Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney. (1993) (68)
- Estimating the contribution of genes and environment to variation in renal drug clearance. (2003) (65)
- Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1 (2009) (63)
- Nucleoside transport in brush border membrane vesicles from human kidney. (1992) (63)
- Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient (1980) (61)
- Molecular Determinants of Substrate Selectivity in Na+-dependent Nucleoside Transporters* (1997) (61)
- Evaluation of methods for producing renal dysfunction in rats. (1981) (60)
- The Cardiac Effects of d‐ and 1‐Disopyramide in Normal Subjects: A Noninvasive Study (1982) (59)
- A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization (2019) (59)
- Creating and evaluating genetic tests predictive of drug response (2008) (59)
- Vorinostat Increases Expression of Functional Norepinephrine Transporter in Neuroblastoma In Vitro and In Vivo Model Systems (2011) (57)
- Interaction of Nucleoside Analogues with the Sodium–Nucleoside Transport System in Brush Border Membrane Vesicles from Human Kidney (1993) (57)
- Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma. (1980) (57)
- Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. (2008) (55)
- Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin (2014) (55)
- Functional genomics of membrane transporters in human populations. (2005) (55)
- Functional and Molecular Characteristics of Na+-dependent Nucleoside Transporters (1997) (54)
- Functional Genetic Diversity in the High-Affinity Carnitine Transporter OCTN2 (SLC22A5) (2006) (54)
- Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2 (2005) (54)
- Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3) (2005) (54)
- Pharmacogenomics of membrane transporters: past, present and future. (2010) (52)
- Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. (2013) (52)
- Pharmacogenomics and Patient Care: One Size Does Not Fit All (2012) (51)
- The effect of probenecid on the renal elimination of cimetidine (1989) (50)
- Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. (2009) (50)
- The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose (1989) (49)
- Genetic variation in human P450 oxidoreductase (2009) (48)
- Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells (2016) (48)
- Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. (2001) (47)
- The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin‐Associated Musculoskeletal Symptoms (2022) (47)
- Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). (2017) (46)
- A research roadmap for next-generation sequencing informatics (2016) (45)
- Interactions of organic anions with the organic cation transporter in renal BBMV. (1988) (45)
- Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). (2018) (45)
- Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). (2013) (45)
- The activities of drug inactive ingredients on biological targets (2020) (45)
- Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). (2007) (44)
- The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange. (1987) (44)
- Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice (2010) (44)
- The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin (2016) (43)
- Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers (2019) (41)
- Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group (2012) (41)
- The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development (2018) (41)
- High Selectivity of the γ-Aminobutyric Acid Transporter 2 (GAT-2, SLC6A13) Revealed by Structure-based Approach* (2012) (41)
- FUNCTIONAL CHARACTERIZATION AND HAPLOTYPE ANALYSIS OF POLYMORPHISMS IN THE HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER, ENT2 (2006) (40)
- Identification and characterization of 3-iodothyronamine intracellular transport. (2009) (40)
- Organic cation transport in human renal brush-border membrane vesicles. (1991) (40)
- Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. (1994) (40)
- High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol. (1986) (40)
- Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney. (1987) (39)
- Serine 318 Is Essential for the Pyrimidine Selectivity of the N2 Na+-Nucleoside Transporter* (1999) (38)
- Functional Genetic Variation in the Basal Promoter of the Organic Cation/Carnitine Transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5) (2009) (38)
- Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content (2018) (38)
- Genomic Characterization of Metformin Hepatic Response (2016) (38)
- The pharmacokinetics of the enantiomers of atenolol (1989) (37)
- Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity (2018) (37)
- The role of ATM in response to metformin treatment and activation of AMPK (2012) (37)
- Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression and Promoter Activity Predict Variation (2009) (37)
- Rational aspirin dosage regimens (1978) (36)
- Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia (2013) (35)
- Genome-Wide Discovery of Drug-Dependent Human Liver Regulatory Elements (2014) (35)
- Mechanisms of Nucleobase Transport in Rabbit Choroid Plexus (1995) (34)
- Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions (2018) (34)
- Prediction and validation of enzyme and transporter off-targets for metformin (2015) (34)
- Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt (1980) (33)
- Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system. (1999) (33)
- The Organic Cation Transporter, OCTN1, Expressed in the Human Heart, Potentiates Antagonism of the HERG Potassium Channel (2009) (33)
- LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. (2016) (33)
- LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. (2016) (33)
- Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. (2010) (32)
- Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum. (1980) (32)
- Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition. (2002) (32)
- Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients * (1980) (31)
- A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster (2019) (31)
- Identification and Characterization of Proximal Promoter Polymorphisms in the Human Concentrative Nucleoside Transporter 2 (SLC28A2) (2009) (31)
- Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue (2019) (30)
- A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans. (2001) (29)
- Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities (2019) (29)
- Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters (2011) (29)
- Cimetidine transport in isolated brush border membrane vesicles from bovine choroid plexus. (1990) (28)
- Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes (2018) (27)
- Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans (2016) (27)
- Nicotine transport in a human choriocarcinoma cell line (JAR). (1998) (26)
- Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response (2018) (26)
- A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome (2015) (25)
- The Effect of Uremic Solutes on the Organic Cation Transporter 2. (2017) (25)
- Plasma Protein Binding of d‐Propoxyphene in Normal Subjects and Anephric Patients (1978) (25)
- Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives (2019) (25)
- Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. (2002) (25)
- Characterization of a bioengineered chimeric Na+-nucleoside transporter. (1999) (24)
- Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography. (1982) (24)
- ITC Commentary on Metformin Clinical Drug–Drug Interaction Study Design That Enables an Efficacy‐ and Safety‐Based Dose Adjustment Decision (2018) (24)
- Opportunities and challenges for the computational interpretation of rare variation in clinically important genes (2021) (24)
- High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood. (1982) (24)
- Transport of organic cations by a renal epithelial cell line (OK). (1991) (24)
- SLC19A1 pharmacogenomics summary (2010) (24)
- The Pharmacokinetics and Pharmacodynamics of d- and dl-Verapamil in Rabbits (1985) (24)
- The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers (2016) (24)
- Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. (2010) (23)
- Genetic variation in human aquaporins and effects on phenotypes of water homeostasis (2008) (23)
- Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes. (2000) (23)
- Decreased Binding of Verapamil to Plasma Proteins in Patients with Liver Disease (1984) (23)
- PharmGKB summary: very important pharmacogene information for SLC22A1 (2014) (22)
- R 2 MEMBRANE TRANSPORTERS AND DRUG RESPONSE (2005) (22)
- In vivo interaction of the enantiomers of disopyramide in human subjects (1986) (22)
- Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins. (1980) (22)
- GenEpi: gene-based epistasis discovery using machine learning (2018) (22)
- A New Era in Pharmacovigilance: Toward Real‐World Data and Digital Monitoring (2021) (21)
- Molecular Determinants of Specificity for Synthetic Nucleoside Analogs in the Concentrative Nucleoside Transporter, CNT2* (2006) (20)
- Discovery of Regulatory Elements in Human ATP-Binding Cassette Transporters through Expression Quantitative Trait Mapping (2011) (20)
- High-performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. II. Studies with atenolol. (1989) (20)
- Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies (2019) (19)
- Sorting of Rat SPNT in Renal Epithelium Is Independent of N-Glycosylation (2003) (19)
- The effects of modulation of calcium influx through the voltage-sensitive calcium channel on cardiomyocyte hypertrophy. (1995) (19)
- Effect of Concentration-Dependent Binding to Plasma Proteins on the Pharmacokinetics and Pharmacodynamics of Disopyramide (1984) (19)
- Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction. (1992) (19)
- Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney. (1988) (18)
- Species Differences in the Negative Inotropic Response of 1,4‐Dihydropyridine Calcium Channel Blockers in Myocardium (1988) (18)
- PharmGKB summary: very important pharmacogene information for ABCG2 (2017) (18)
- Drug–nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3) (2019) (18)
- PharmGKB Submission Update: IV. PMT Submissions of Genetic Variations in ATP-Binding Cassette Transporters to the PharmGKB Network (2006) (17)
- Membrane Transporters in Drug Disposition (1997) (17)
- Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. (1994) (17)
- Genome‐Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol (2019) (16)
- The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide (1982) (16)
- Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. (2017) (16)
- Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease. (2005) (16)
- Molecular and functional characteristics of cloned human organic cation transporters. (1999) (16)
- The Stereoselective Disposition of Disopyramide in the Dog (1980) (16)
- Unmet needs: Research helps regulators do their jobs (2015) (15)
- OCT1 in hepatic steatosis and thiamine disposition (2015) (15)
- Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas (2021) (15)
- Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles. (1991) (15)
- Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP. (2020) (15)
- Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies (2020) (15)
- Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium. (1987) (15)
- Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells. (1992) (15)
- Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy. (1994) (14)
- Mechanisms of interactions between organic anions and the organic cation transporter in renal brush border membrane vesicles. (1990) (14)
- Primary Cell Culture of the Rabbit Choroid Plexus: An Experimental System to Investigate Membrane Transport (1996) (14)
- Calculation of drug concentration in plasma after equilibrium dialysis. (1982) (14)
- A survey of integral α-helical membrane proteins (2009) (13)
- Saturable disposition of taurine in the rat cerebrospinal fluid. (1996) (13)
- Stereoselective Interactions of Organic Cations with the Organic Cation Transporter in OK Cells (1993) (13)
- Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration (1984) (12)
- Pharmacogenetics of Antidiabetic Drugs. (2018) (12)
- Emerging Roles of the Human Solute Carrier 22 Family (2021) (12)
- Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs. (1980) (12)
- Na+-dependent γ-aminobutyric acid (GABA) transport in the choroid plexus of rabbit (1997) (12)
- A Molecular Basis for Innovation in Drug Excipients (2017) (12)
- Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes. (1994) (12)
- Preparation of brush border membrane vesicles from bovine choroid plexus. (1991) (12)
- Functional and structural analysis of rare SLC2A2 variants associated with Fanconi‐Bickel syndrome and metabolic traits (2019) (12)
- Guanidine Transport in a Human Choriocarcinoma Cell Line (JAR) (1997) (12)
- Molecular Cloning of a Na+-Dependent Nucleoside Transporter1 from Rabbit Intestine (2000) (11)
- Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer. (2017) (11)
- PharmGKB Submission Update: V. PMT Submissions of Genetic Variation in SLC22 Family Transporters (2006) (10)
- Taurine Transport in Cultured Choroid Plexus (1997) (10)
- Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3. (2020) (10)
- The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site. (1986) (10)
- GABAA receptor open-state conformation determines non-competitive antagonist binding. (2011) (10)
- COVID‐19: A Defining Moment for Clinical Pharmacology? (2020) (10)
- Drugs in COVID‐19 Clinical Trials: Predicting Transporter‐Mediated Drug‐Drug Interactions Using In Vitro Assays and Real‐World Data (2021) (9)
- OCT (SLC22A) and OCTN Family (2013) (9)
- l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan. (2019) (9)
- Transient Expression of a Purine-Selective Nucleoside Transporter (SPNTint) in a Human Cell Line (HeLa) (1997) (9)
- Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing. (2007) (9)
- Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. (1981) (8)
- PharmGKB Update: I. Genetic Variants of the Organic Cation Transporter 2 (OCT2, SLC22A2) (2003) (8)
- Research Projects Supported by the University of California, San Francisco‐Stanford Center of Excellence in Regulatory Science and Innovation (2019) (7)
- Expression of the choroid plexus sodium-nucleoside cotransporter (N3) in Xenopus laevis oocytes. (1994) (7)
- Characterization of Guanidine Transport in Human Renal Brush Border Membranes (1997) (7)
- Clinical Pharmacology & Therapeutics 2030 (2020) (7)
- High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3 (2022) (6)
- PS1-10: Response to Metformin and Genetic Variants of Organic Cation and Multidrug and Toxin Extrusion Transporters (2010) (6)
- Scientific considerations for global drug development (2020) (6)
- Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters (2019) (6)
- Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics (2019) (6)
- Effect of Probenecid on the Pharmacokinetics and Pharmacodynamics of Procainamide (1991) (6)
- Essential tyrosine residues in transport of organic cations in renal BBMV. (1987) (6)
- PharmGKB Update: III. Genetic Variants of SLC22A1, Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (2004) (5)
- Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes. (1997) (5)
- Formycin B Elimination from the Cerebrospinal Fluid of the Rat (1993) (5)
- Expression of a renal Na+-nucleoside cotransport system (N2) in Xenopus laevis oocytes (1994) (5)
- Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein (2021) (5)
- Stereoselective Binding of Disopyramide to Plasma Proteins (1988) (5)
- Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins (2021) (5)
- Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil. (1986) (5)
- SNP Analysis and Presentation in the Pharmacogenetics of Membrane Transporters Project (2002) (4)
- Cellular transporter pharmacogenetics in metastatic colorectal cancer: Initial analysis of C80203 (2008) (4)
- Na1-dependent purine nucleoside transporter from human kidney: cloning and functional characterization (1997) (4)
- PharmGKB Submission Update: VI. PMT Submissions of Genetic Variations in Neurotransmitter Transporters (SLC6, SLC17, and SLC18) to the PharmGKB Network (2006) (4)
- Organic Cation Transporters (2006) (4)
- A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster (2018) (4)
- Oral Anticoagulants and Precision Medicine: Something Old, Something New (2020) (4)
- New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium (2022) (4)
- Effect of phenylisothiocyanate on organic cation transport in opossum kidney cells. (1994) (4)
- rapid communication Na 1 -dependent purine nucleoside transporter from human kidney: cloning and functional characterization (1997) (3)
- Electrophysiology of the Enantiomers of Disopyramide in Dogs (1985) (3)
- A convenient method for repetitive blood sampling in the dog (1978) (3)
- Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. (1997) (3)
- Nucleoside Transport in Isolated Human and Rhesus Choroid Plexus Tissue Slices (1998) (3)
- Methods of study drug transport in isolated choroid plexus tissue and cultured cells. (1996) (3)
- A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption (2022) (3)
- Renal Transport of Drugs: An Overview of Methodology with Application to Cimetidine (1988) (3)
- Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4) (2007) (3)
- Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics (2021) (3)
- Academic pharmaceutics: The challenge of excellence (1990) (3)
- Cimetidine Elimination from the Cerebrospinal Fluid of the Rat (1988) (3)
- Dedication to Professor Leslie Z. Benet: 50 Years of Scientific Excellence and Still Going Strong! (2012) (3)
- Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter (2020) (2)
- Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin. (1983) (2)
- Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. (2009) (2)
- The use of drug transporters as therapeutic targets. (2016) (2)
- Abstract of papers to be presented at the 31st annual scientific session of the American College of Cardiology Atlanta, Georgia, April 25–29, 1982The cardiac effects of disopyramide isomers (1982) (2)
- Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network (2021) (2)
- Rapid Method to Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in OCT1-transfected HEK Cells (2015) (2)
- Functional Characterization and Haplotype Analysis of Polymorphisms in the Human Equilibrative Nucleoside Transporter , ENT 2 (2005) (2)
- The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus. (1995) (2)
- Mechanisms of 5-Fluorouracil (5-FU) Transport in Isolated Rabbit Choroid Plexus Tissue Slices (1996) (2)
- Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel. (1986) (2)
- Enhancing Data Sharing in Collaborative Research Projects with DASH (2004) (2)
- In Vitro Evaluation of Excipients as Inhibitors of Human Intestinal P‐glycoprotein (2019) (2)
- Special Section on Pharmacogenomics: recent advances and future directions (2013) (2)
- SYNTHESIS AND ANTICHOLINERGIC PROPERTIES OF THE ENANTIOMERS OF 4-(ISOPROPYLAMINO)-2-(2-PYRIDYL)-2-PHENYLBUTYRAMIDE, THE MONO-N-DEALKYLATED METABOLITE OF DISOPYRAMIDE (1981) (1)
- The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology (2022) (1)
- A tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research. (2020) (1)
- Ribavirin analogs as concentrative nucleoside transporter 2 inhibitors (2020) (1)
- The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles. (1988) (1)
- The Pharmacogenomics of Membrane Transporters Project (2013) (1)
- Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man (2004) (1)
- Pharmacogenomic mechanisms of drug toxicity (2022) (1)
- High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma. (1984) (1)
- SLCO1B1 Variation and Methotrexate Disposition in Children with Acute Lymphoblastic Leukemia: The Importance of Rare Variants in Pharmacogenetics (2011) (1)
- Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. (1996) (1)
- The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2 (2021) (1)
- Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response (2020) (1)
- Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency (2022) (1)
- Presidential Trainee Awards (PT 1–21) Attended 4:30 pm – 5:00 pm Displayed March 6 – 9, 2013 (2013) (1)
- Identification of Genetic Variation Influencing Metformin Response in a Multi-Ancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). (2022) (1)
- A Neural Network Model for Predicting Treatment Response of Antidepressant in Patients with Major Depressive Disorder (2012) (0)
- THE ACTIVITIES OF ORGANIC ANION TRANSPORTERS, OATP1B1/1B3 AND OAT1/3 ARE MODULATED BY UREMIC TOXINS. (2016) (0)
- Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All (2023) (0)
- CorrigendumCorrigendum to “Nucleoside transporters in the disposition and targeting of nucleoside 2 analogs in the kidney” [Eur. J. Pharmacol. 479/1–3 (2003) 269–281] (2004) (0)
- Novel Mutations in OCTN2 Identified in Newborn Screening Exhibit Reduced Function and Lead to Carnitine Transporter Deficiency (2020) (0)
- Oral Session II‐B (OII‐B) (2011) (0)
- Special Section on New Era of Transporter Science — Minireview Emerging Roles of the Human Solute Carrier 22 Family S (2022) (0)
- Strategies in Personalized Medicine: The Role of Pharmaceutics in Predictive Drug Therapy (2006) (0)
- Intestinal Diamine Oxidase: A Potential New Target For Metformin.: pi-44 (2013) (0)
- Genomics of Transporters: Implications to Drug Discovery, Development and Response (2018) (0)
- Sodium Dependent Taurine Transport into the Choroid Plexus, the Blood-Cerebrospinal Fluid Barrier (1995) (0)
- Identification and functional characterization of variants of the human organic anion transporter, OAT3 (SLC22A8) (2004) (0)
- More Than Pharmacokinetics: Transporters in Clinical Pharmacology (2022) (0)
- Selective hyperpolarized 13 C metabolic signal suppression from a liver-specific gadolinium contrast agent measured using an NMR-compatible perfusion bioreactor (2019) (0)
- Endogenous biomarkers for drug metabolism and transporter activity (2019) (0)
- Studies on Ca2+ Channel Antagonists. 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentyl Isothiocyanate, a Chemoaffinity Ligand Derived from Verapamil. (1987) (0)
- The A BC o f S olute C arriers (2004) (0)
- Opportunities and Challenges for Interpreting Rare Variation in Clinically Important Genes (2020) (0)
- Title Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin Permalink (2015) (0)
- Genome-Wide Meta-Analysis Identifies the Organic Anion-Transporting Polypeptide Gene SLCO1B1 and Statins as Modifiers of Glycemic Response to Sulfonylureas (2021) (0)
- Abstract 1195: Oct-1 as a potential biomarker for oxaliplatin-based therapy in non-small cell lung cancer (2010) (0)
- Effects of substituent size and linker orientation on LAT1-targeted amino acid prodrugs (2020) (0)
- Reduced‐function polymorphisms in the high‐affinity carnitine transporter OCTN2 (SLC22A5) (2006) (0)
- OF THE SUBSTRATE SELECTIVITY OF A SODIUM-COUPLED NUCLEOSIDE TRANSPORTER ( rCNT 1 ) EXPRESSED IN XENOPUS LAEVIS OOCYTES (2000) (0)
- Stereoselective Renal Elimination (2003) (0)
- Prediction and validation of enzyme and transporter off-targets for metformin (2015) (0)
- Renal Disposition of Drugs and Translation to Dosing Strategies (2013) (0)
- GenEpi: gene-based epistasis discovery using machine learning (2020) (0)
- Functional Characterization of a Human Purine-Selective , Na 1-Dependent Nucleoside Transporter ( hSPNT 1 ) in a Mammalian Expression System 1 (1999) (0)
- Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (1997) (0)
- Targeting Influx Transporters in the Human Blood Brain Barrier (2014) (0)
- Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673–2682 (2022) (0)
- S7.2 - Transporter polymorphisms drive inter-ethnic differences in drug response (2020) (0)
- Contributors (2022) (0)
- IN VITRO EFFECTS OF HEPARIN ADMINISTRATION ON FREE THYROXINE CONCENTRATIONS (1984) (0)
- Pharmacogenetics of Metformin (2016) (0)
- Genome-wide Association Study Identifies ABCG2 (BCRP) as an Allopurinol Transporter and a Determinant of Drug Response Authors (2014) (0)
- Dedication to Professor Leslie Z. Benet: 50 Years of Scientific Excellence and Still Going Strong! (2012) (0)
- University of Dundee Variation in the Glucose Transporter gene SLC 2 A 2 is associated with glycaemic response to metformin (2016) (0)
- JPET # 170159 1 Genetic Polymorphisms in the Organic Cation Transporter 1 , OCT 1 , in Chinese and Japanese Populations , Exhibit Altered Function (2010) (0)
- Characterization of an organic cation transporter in a human choriocarcinoma cell line (JAR) (1996) (0)
- Pharmacogenomics of membrane transporters (2017) (0)
- Cardiac contraction and relaxation are regulated by beta 1 adrenergic receptor-generated cAMP pools at distinct membrane locations (2023) (0)
- The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity (2018) (0)
- A Whole Genome Analysis Identifies SLCO1B1 as a Determinant of Methotrexate Pharmacokinetics and Adverse Effects (2008) (0)
- Chapter 4 – Pharmacogenetics: Focus on the Liver (2006) (0)
- American Society for Clinical Pharmacology and Therapeutics (1975) (0)
- Biomarkers Come of Age in Clinical Pharmacology (2023) (0)
- Functional Characterization of GAT-2 1 High selectivity of the γ-Aminobutyric acid ( GABA ) transporter 2 ( GAT-2 , SLC 6 A 13 ) revealed by structure-based approach (2012) (0)
- American Society for Clinical Pharmacology and Therapeutics (1975) (0)
- Presidential Trainee Awards (PT 001–024) Attended 4:30 pm – 5:00 pm Displayed March 19 – 21, 2014 (2014) (0)
- Characterization of a Human Purine-Selective Nucleoside Transporter (hSPNT) in transfected cells (1998) (0)
- Verapamil Interacts Stereoselectively with the Muscarinic Receptor (1985) (0)
- Faculty Opinions recommendation of Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. (2011) (0)
- Germline Genetic Polymorphisms Are Associated with Disease-Free Survival in Adults with Acute Myeloid Leukemia (AML): A Genomewide Association Study From the Pgrn-Riken Global Alliance. (2012) (0)
- University of Dundee Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes Rotroff, (2018) (0)
- Lewis B. Sheiner, 1940–2004 (2004) (0)
- Renal transporters: Mediators of drug disposition and action (2018) (0)
- GPCR-dependent spatiotemporal cAMP generation confers functional specificity in cardiomyocytes and cardiac responses (2022) (0)
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