Kathleen Matthews
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American Biochemist
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Kathleen Matthews biology Degrees
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Biology
Kathleen Matthews 's Degrees
- Bachelors Biochemistry University of California, Berkeley
- PhD Biochemistry Stanford University
Why Is Kathleen Matthews Influential?
(Suggest an Edit or Addition)According to Wikipedia, Kathleen Matthews is an American biochemist specializing in DNA/protein interactions, specifically related to the lac repressor. She is the Stewart Memorial Professor Emerita of BioSciences at Rice University.
Kathleen Matthews 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The lactose repressor system: paradigms for regulation, allosteric behavior and protein folding (2006) (171)
- Thermal denaturation of the core protein of lac repressor. (1985) (149)
- Allostery in the LacI/GalR family: variations on a theme. (2009) (133)
- Deletion of lactose repressor carboxyl-terminal domain affects tetramer formation. (1992) (101)
- Generation of an AraC-araBAD promoter-regulated T7 expression system. (2000) (98)
- DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor. (1980) (85)
- Equilibrium binding of inducer to lac repressor.operator DNA complex. (1980) (79)
- Multiple Intrinsically Disordered Sequences Alter DNA Binding by the Homeodomain of the Drosophila Hox Protein Ultrabithorax* (2008) (79)
- Influence of sequence and distance between two operators on interaction with the lac repressor. (1987) (74)
- Lactose repressor protein: functional properties and structure. (1998) (73)
- Macromolecular binding equilibria in the lac repressor system: studies using high-pressure fluorescence spectroscopy. (1990) (70)
- Engineered temperature compensation in a synthetic genetic clock (2014) (64)
- Operator DNA sequence variation enhances high affinity binding by hinge helix mutants of lactose repressor protein. (2000) (63)
- Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein. (2008) (60)
- Subunit dissociation affects DNA binding in a dimeric lac repressor produced by C-terminal deletion. (1994) (60)
- Thermodynamic analysis of the lactose repressor-operator DNA interaction. (1986) (59)
- Evidence for leucine zipper motif in lactose repressor protein. (1991) (59)
- Allosteric transition pathways in the lactose repressor protein core domains: Asymmetric motions in a homodimer (2003) (56)
- Physical and Genetic Interactions Link Hox Function with Diverse Transcription Factors and Cell Signaling Proteins* (2006) (54)
- Dissociation of the lactose repressor protein tetramer using high hydrostatic pressure. (1986) (52)
- Tetramer opening in LacI-mediated DNA looping (2009) (51)
- Influence of supercoiling and sequence context on operator DNA binding with lac repressor. (1987) (50)
- Resolution of the fluorescence decay of the two tryptophan residues of lac repressor using single tryptophan mutants. (1990) (48)
- Dissociation of the lactose repressor-operator DNA complex: effects of size and sequence context of operator-containing DNA. (1986) (47)
- Characterization of mutations in oligomerization domain of Lac repressor protein. (1991) (47)
- Characterization of the folding landscape of monomeric lactose repressor: quantitative comparison of theory and experiment. (2005) (47)
- Thermodynamic analysis of unfolding and dissociation in lactose repressor protein. (1999) (47)
- Plasticity of quaternary structure: Twenty‐two ways to form a LacI dimer (2001) (44)
- Supercoiling facilitates lac operator-repressor-pseudooperator interactions. (1987) (44)
- Glycine Insertion in the Hinge Region of Lactose Repressor Protein Alters DNA Binding* (1999) (43)
- Analytical ultracentrifugation for characterizing nanocrystals and their bioconjugates. (2005) (43)
- Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability. (2002) (43)
- Development of a chemically defined serum- and protein-free medium for growth of human peripheral lymphocytes. (1986) (41)
- Perturbation from a distance: mutations that alter LacI function through long-range effects. (2003) (40)
- Extrinsic interactions dominate helical propensity in coupled binding and folding of the lactose repressor protein hinge helix. (2006) (40)
- Kinetic studies of inducer binding to lac repressor.operator complex. (1980) (38)
- Fine‐tuning function: Correlation of hinge domain interactions with functional distinctions between LacI and PurR (2002) (38)
- Effect of lac repressor oligomerization on regulatory outcome (1992) (38)
- Integrated insights from simulation, experiment, and mutational analysis yield new details of LacI function. (2005) (36)
- Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor. (2009) (35)
- Interaction of lac repressor with inducer, kinetic and equilibrium measurements. (1977) (35)
- Engineered disulfide linking the hinge regions within lactose repressor dimer increases operator affinity, decreases sequence selectivity, and alters allostery. (2001) (33)
- Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator. (2001) (30)
- The experimental folding landscape of monomeric lactose repressor, a large two-domain protein, involves two kinetic intermediates. (2005) (29)
- Characterization and modification of a monomeric mutant of the lactose repressor protein. (1986) (29)
- Predicted structure of the sugar-binding site of the lac repressor (1984) (29)
- Dependence of trp repressor-operator affinity, stoichiometry, and apparent cooperativity on DNA sequence and size. (1993) (29)
- Altering protein surface charge with chemical modification modulates protein–gold nanoparticle aggregation (2011) (29)
- Hox Transcription Factor Ultrabithorax Ib Physically and Genetically Interacts with Disconnected Interacting Protein 1, a Double-stranded RNA-binding Protein* (2004) (28)
- Wild-type operator binding and altered cooperativity for inducer binding of lac repressor dimer mutant R3. (1994) (28)
- Tryptic core protein of lactose repressor binds operator DNA. (1979) (28)
- Shell formation by capsid protein of f2 bacteriophage. (1972) (28)
- Correlation of immunologic and nutritional status with infectious complications after major abdominal trauma. (1986) (27)
- Kinetic and Thermodynamic Studies of Purine Repressor Binding to Corepressor and Operator DNA* (1998) (26)
- Designed Disulfide between N-terminal Domains of Lactose Repressor Disrupts Allosteric Linkage* (1997) (26)
- Model of lactose repressor core based on alignment with sugar-binding proteins is concordant with genetic and chemical data. (1993) (25)
- Substitutions at histidine 74 and aspartate 278 alter ligand binding and allostery in lactose repressor protein. (1999) (24)
- Ultraviolet difference spectra of the lactose repressor protein. (1973) (24)
- Identification of amino acids in lac repressor protein cross-linked to operator DNA specifically substituted with bromodeoxyuridine. (1991) (24)
- Lysine 84 is at the subunit interface of lac repressor protein. (1993) (24)
- Formation of mixed disulfide adducts at cysteine-281 of the lactose repressor protein affects operator and inducer binding parameters. (1986) (23)
- Allosteric regulation of inducer and operator binding to the lactose repressor. (1986) (22)
- Flexibility in the inducer binding region is crucial for allostery in the Escherichia coli lactose repressor. (2009) (21)
- Ligand-induced conformational changes in lactose repressor: a phosphorescence and ODMR study of single-tryptophan mutants. (1999) (20)
- The Drosophila transcription factor ultrabithorax self-assembles into protein-based biomaterials with multiple morphologies. (2009) (20)
- Arginine 197 of lac repressor contributes significant energy to inducer binding. Confirmation of homology to periplasmic sugar binding proteins. (1991) (20)
- Tryptophan and 8-anilino-1-naphthalenesulfonate compete for binding to trp repressor. (1989) (20)
- The Whole Lactose Repressor (1996) (20)
- Interactions between lac repressor protein and site-specific bromodeoxyuridine-substituted operator DNA. Ultraviolet footprinting and protein-DNA cross-link formation. (1991) (20)
- Combinatorial Mutations of lac Repressor (1997) (19)
- Transcription activation by ultrabithorax Ib protein requires a predicted α-helical region (2002) (19)
- Positions 94-98 of the lactose repressor N-subdomain monomer-monomer interface are critical for allosteric communication. (2010) (19)
- Ligand-induced conformational changes in lactose repressor: a fluorescence study of single tryptophan mutants. (1997) (18)
- Exposure of antigenic sites during immunization. Monoclonal antibodies to monomer of lactose repressor protein. (1985) (18)
- Ion concentration and temperature dependence of DNA binding: comparison of PurR and LacI repressor proteins. (2001) (18)
- Model for lactose repressor protein and its interaction with ligands. (1980) (18)
- Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins* (2015) (18)
- Protein-DNA binding correlates with structural thermostability for the full-length human p53 protein. (2001) (18)
- Chemical modification of lactose repressor protein using N-substituted maleimides. (1979) (18)
- Construction of a dimeric repressor: dissection of subunit interfaces in Lac repressor. (1994) (18)
- Electrostatic forces contribute to interactions between trp repressor dimers. (1994) (17)
- Ultraviolet difference spectra of the lactose repressor protein. II. Trypsin core protein. (1974) (17)
- trp repressor mutations alter DNA complex stoichiometry. (1994) (17)
- Modification of tyrosine residues of the lactose repressor protein. (1977) (17)
- Hybrid tetramers of native and core lactose repressor protein. Assessment of operator and nonspecific DNA binding parameters and their relationship. (1980) (16)
- The Intrinsically Disordered Regions of the Drosophila melanogaster Hox Protein Ultrabithorax Select Interacting Proteins Based on Partner Topology (2014) (16)
- Comparison of simulated and experimentally determined dynamics for a variant of the Lacl DNA-binding domain, Nlac-P. (1998) (16)
- Differences in water release with DNA binding by ultrabithorax and deformed homeodomains. (1997) (16)
- Lactose repressor protein modified with dansyl chloride: activity effects and fluorescence properties. (1985) (16)
- Serine to cysteine mutations in trp repressor protein alter tryptophan and operator binding. (1989) (16)
- Identification and characterization of aspartate residues that play key roles in the allosteric regulation of a transcription factor: aspartate 274 is essential for inducer binding in lac repressor. (1994) (16)
- N-Bromosuccinimide modification of Lac repressor protein. (1977) (15)
- Size dictates mechanical properties for protein fibers self-assembled by the Drosophila hox transcription factor ultrabithorax. (2010) (15)
- Ligand interactions with lactose repressor protein and the repressor-operator complex: the effects of ionization and oligomerization on binding. (2007) (15)
- Functionalization and Patterning of Protein‐Based Materials Using Active Ultrabithorax Chimeras (2011) (14)
- Functional impact of polar and acidic substitutions in the lactose repressor hydrophobic monomer.monomer interface with a buried lysine. (2009) (14)
- Protein chemical modification as probe of structure-function relationships. (1991) (14)
- Effect of amino acid alterations in the tryptophan-binding site of the trp repressor. (1990) (14)
- Monitoring DNA binding to Escherichia coli lactose repressor using quartz crystal microbalance with dissipation. (2011) (14)
- Role of Asp274 in lac repressor: diminished sugar binding and altered conformational effects in mutants. (1995) (14)
- Tetranitromethane modification of the tyrosine residues of the lactose repressor. (1981) (13)
- Nutritional requirements for growth of human lymphocytes. (1988) (13)
- T41 mutation in lac repressor is Tyr282----Asp. (1992) (13)
- pH-dependent enhancement of DNA binding by the ultrabithorax homeodomain. (1996) (13)
- p53 unfolding detected by CD but not by tryptophan fluorescence. (2001) (12)
- Lactose repressor protein modified with fluorescein mercuric acetate. (1978) (12)
- Altering residues N125 and D149 impacts sugar effector binding and allosteric parameters in Escherichia coli lactose repressor. (2011) (12)
- Activity changes in lac repressor with cysteine oxidation. (1979) (12)
- Modification of the cysteine residues of the lactose repressor protein using chromophoric probes. (1977) (12)
- Thermodynamic analysis of inducer binding to the lactose repressor protein: contributions of galactosyl hydroxyl groups and beta substituents. (1987) (12)
- Thermodynamics, protein modification, and molecular dynamics in characterizing lactose repressor protein: strategies for complex analyses of protein structure-function. (2004) (12)
- Kinetic studies of inducer binding to lactose repressor protein. (1976) (10)
- Relieving repression (2000) (10)
- Enzymatic digestion of operator DNA in the presence of the lac repressor tryptic core. (1984) (10)
- The Effect of Protein Fusions on the Production and Mechanical Properties of Protein‐Based Materials (2015) (9)
- Characterization of two mutant lactose repressor proteins containing single tryptophans. (1990) (9)
- Lactose repressor protein reaction with 2-chloromercuri-4-nitrophenol. (1976) (9)
- Characterization of Mutants Affecting the KRK Sequence in the Carboxyl-terminal Domain of lac Repressor (*) (1995) (9)
- DNA binding to protein-gold nanocrystal conjugates. (2006) (9)
- A Tale of Two Proteins (2015) (9)
- A mutant lactose repressor with altered inducer and operator binding parameters. (1985) (9)
- Fluorescence and ultraviolet spectral studies of Lac repressor modified with N-bromosuccinimide. (1977) (7)
- Trinitrobenzenesulfonate modification of the lysine residues in lactose repressor protein. (1984) (7)
- Protective effect of vitamin E on lymphocyte growth capacity during incubation in vitro (1995) (7)
- Inducer binding to lac repressor: effects of poly[d(A-T)] and trypsin digestion. (1978) (7)
- DNA looping (1992) (7)
- lac operator DNA modification in the presence of proteolytic fragments of the repressor protein. (1984) (6)
- Trp repressor interaction with bromodeoxyuridine-substituted operators alters UV-induced perturbation pattern in a sequence-dependent manner. (1993) (6)
- Transcription activation by ultrabithorax Ib protein requires a predicted alpha-helical region. (2002) (6)
- Determination of the ligand-binding characteristics of several tight-binding mutants of the lactose repressor protein. (1981) (5)
- Mapping and analysis of protein sulfhydryl groups by modification with 2-bromoacetamido-4-nitrophenol. (1987) (5)
- Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT. (2011) (5)
- Spectral studies on lac repressor modified with N-substituted maleimide probes. (1979) (5)
- Dietary deprivation of B-vitamins reflected in murine splenocyte proliferation in vitro. (1994) (5)
- Glucose and insulin responses in isolated human lymphocytes reflect in vivo status: effects of VLCD treatment. (1994) (5)
- Glycerol-3-phosphate dehydrogenase activity in human lymphocytes: effects of insulin, obesity and weight loss. (1995) (5)
- Spectral studies of lactose repressor protein modified with nitrophenol reporter groups. (1977) (5)
- Perturbation of lac operator DNA modification by tryptic core protein from lac repressor. (1983) (5)
- Measuring Hox-DNA binding by electrophoretic mobility shift analysis. (2014) (4)
- Lymphocyte function and abdominal operations. Trauma vs elective surgery. (1987) (4)
- Chemical modification of arginine residues in the lactose repressor. (1987) (4)
- Energy transfer in lactose repressor protein modified with N-[[(iodoacetyl)amino]ethyl]-5-naphthylamine-1-sulfonate. (1991) (4)
- Media composition influences yeast one- and two-hybrid results (2011) (4)
- Effects of chemical modification of f2 viral coat protein on its shell-forming activity. (1972) (4)
- Exposure of Antigenic Sites during Immunization (1985) (3)
- Lactose repressor hinge domain independently binds DNA (2018) (3)
- Chemically defined medium for the growth of lymphocytes. (1987) (3)
- Human lymphocytes incubated in vitro share multiple characteristics with geriatric-derived lymphocytes: a potential in vitro model for aging? (1995) (3)
- Mutation in hinge region of lactose repressor protein alters physical and functional properties. (1989) (3)
- High affinity, dsRNA binding by disconnected interacting protein 1. (2010) (3)
- Regulation of the lactose repressor. (1988) (3)
- Evolution of the activation domain in a Hox transcription factor. (2018) (2)
- Interaction of lysozyme with f2 bacteriophage. (1972) (2)
- Hox Transcription Factor Ultrabithorax Ib Physically and Genetically Interacts with Disconnected Interacting Protein 1 , a dsRNA binding protein † (2004) (1)
- Characterization of the two tryptophan residues of the lactose repressor from Escherichia coli by phosphorescence and optical detection of magnetic resonance. (1993) (1)
- Lactose Repressor Protein Modified with Fluorescein Mercuric (2012) (1)
- Structure of a Dimeric Lac Repressor with C-terminal Deletion and K84L Substitution (2001) (0)
- Single Molecule Measurements Of The Role Of Tetramer Opening In LacI-mediated DNA Looping (2009) (0)
- Inhibition of the self-assembly of capsid protein from f2 phage by urea. (1972) (0)
- The 2 Nd Texas A&m Eng-life Workshop Welcome! (2015) (0)
- Transcription | lac Operon Regulation (2021) (0)
- Small angle scattering studies of LacI repressor (2007) (0)
- Ultrabithorax, an Intrinsically Disordered Protein, Selects Protein Interactions by Topology (2012) (0)
- The Transcription Factor Ultrabithorax Forms Extensible, Hierarchically Ordered Assemblies that are Readily Functionalized by Gene Fusion (2012) (0)
- pH-dependent DNA binding by homeodomain from ultrabithorax protein (1996) (0)
- 149 Generating context-specific functions with intrinsically disordered domains (2013) (0)
- Evolution of the Intrinsically Disordered Activation Domain in a Hox Transcription Factor (2019) (0)
- Dna Looping By Lactose Repressor Requires Tetramer Opening (2010) (0)
- Lymphocyte Function and Abdominal Operations (1988) (0)
- Protein Folding and Assembly Minireview Series* (1997) (0)
- Generating Context-Specific Functions with Intrinsically Disordered Domains (2011) (0)
- Escherichia coli Repressor Proteins (1989) (0)
- Protein Ultrabithorax Hox Drosophila Homeodomain of the Sequences Alter DNA Binding by the Multiple Intrinsically Disordered Epigenetics : Transcription , Chromatin (2008) (0)
- Minireview Series on Enzyme Superfamilies* (1997) (0)
- Structure of the Dimeric Lac Repressor with an 11-residue C-terminal Deletion. (2001) (0)
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