Kay F. Huebner
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(Suggest an Edit or Addition)Kay F. Huebner's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B (2007) (1603)
- The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers (1996) (1051)
- Molecular cloning of a new transforming gene from a chemically transformed human cell line (1984) (924)
- The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer (1996) (595)
- Replacement of Fhit in cancer cells suppresses tumorigenicity. (1997) (382)
- Reprogramming of miRNA networks in cancer and leukemia. (2010) (374)
- Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase. (1996) (371)
- A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains (1992) (367)
- Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT6 Serotonin Receptor (1996) (366)
- Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice (1995) (364)
- Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. (1988) (364)
- Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA (2012) (363)
- Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas. (1987) (341)
- Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV. (1986) (335)
- Characterization of the Mammalian YAP (Yes-associated Protein) Gene and Its Role in Defining a Novel Protein Module, the WW Domain (*) (1995) (328)
- Cloning and characterization of two members of the vertebrate Dlx gene family. (1994) (276)
- Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. (1993) (271)
- Loss of FHIT function in lung cancer and preinvasive bronchial lesions. (1998) (270)
- FHIT gene alterations in head and neck squamous cell carcinomas. (1996) (255)
- elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. (1989) (248)
- Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. (2004) (240)
- Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. (1988) (235)
- The FHIT gene at 3p14.2 is abnormal in breast carcinomas. (1996) (227)
- The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q- anomaly. (1985) (216)
- Structure and expression of the human FHIT gene in normal and tumor cells. (1997) (210)
- Association between cigarette smoking and FHIT gene alterations in lung cancer. (1997) (200)
- Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer (2005) (188)
- The role of the FHIT/FRA3B locus in cancer. (1998) (183)
- FRA3B and other common fragile sites: the weakest links (2001) (181)
- Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation (2014) (178)
- Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. (1990) (178)
- Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases (1993) (177)
- The tumor spectrum in FHIT-deficient mice (2001) (176)
- Integrated MicroRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer (2013) (165)
- Adenovirus 5 DNA sequences present and RNA sequences transcribed in transformed human embryo kidney cells (HEK-Ad-5 or 293). (1979) (147)
- WWOX gene restoration prevents lung cancer growth in vitro and in vivo (2005) (142)
- Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus. (2000) (142)
- Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. (1994) (140)
- Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. (1992) (139)
- Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities. (1997) (139)
- The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma (2004) (139)
- Muir-Torre-like syndrome in Fhit-deficient mice. (2000) (138)
- microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers (2014) (137)
- Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. (1998) (135)
- FHIT gene therapy prevents tumor development in Fhit-deficient mice (2001) (133)
- Loss of WWOX Expression in Gastric Carcinoma (2004) (133)
- Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion. (1997) (131)
- Cancer-specific chromosome alterations in the constitutive fragile region FRA3B. (1999) (130)
- Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia. (1989) (127)
- WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. (2003) (123)
- FHIT: from gene discovery to cancer treatment and prevention. (2002) (119)
- A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells. (1992) (119)
- Cancer and the FRA3B/FHIT fragile locus: it's a HIT (2003) (118)
- Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines. (1996) (118)
- The histidine triad superfamily of nucleotide‐binding proteins (1999) (116)
- Loss of FHIT expression in gastric carcinoma. (1998) (114)
- Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21. (1989) (112)
- Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. (2012) (111)
- A role for the WWOX gene in prostate cancer. (2006) (109)
- Effect of cell chromosome number on simian virus 40 replication. (1973) (109)
- Role of FHIT in Human Cancer (1999) (107)
- Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. (1994) (106)
- T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice. (1996) (106)
- Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax (1997) (103)
- Deletion mapping of chromosome region 9p21‐p22 surrounding the CDKN2 locus in melanoma (1996) (103)
- Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer. (2001) (103)
- Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells. (2001) (102)
- Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient. (1989) (101)
- Retroposition in a family of carcinoma-associated antigen genes (1993) (101)
- Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene. (1997) (100)
- Role of FHIT in human cancer. (1999) (98)
- WWOX gene and gene product: tumor suppression through specific protein interactions. (2010) (97)
- Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2. (1988) (95)
- The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. (1986) (93)
- Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression (2012) (89)
- Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression (2007) (87)
- Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias. (1986) (87)
- Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes. (1991) (84)
- Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes. (1997) (82)
- Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. (1991) (81)
- Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human. (1986) (78)
- Androgen Receptor Status Is a Prognostic Marker in Non-Basal Triple Negative Breast Cancers and Determines Novel Therapeutic Options (2014) (78)
- Chromosomal mapping of human keratin genes: evidence of non-linkage. (1988) (78)
- Absence or reduction of Fhit expression in most clear cell renal carcinomas. (1998) (78)
- Aberrant FHIT transcripts in Merkel cell carcinoma. (1996) (77)
- The FHIT gene product: tumor suppressor and genome “caretaker” (2014) (76)
- Roles of FHIT and WWOX fragile genes in cancer. (2006) (75)
- Concordant loss of fragile gene expression early in breast cancer development (2005) (74)
- Fhit is a physiological target of the protein kinase Src. (2004) (74)
- Chromosomal localization of the human osteocalcin gene. (1989) (73)
- Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit (2001) (73)
- Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. (1998) (72)
- Identification of a conserved family of Meis1-related homeobox genes. (1997) (72)
- Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding (2003) (71)
- The human c-ros gene (ROS) is located at chromosome region 6q16----6q22. (1986) (71)
- Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells. (1981) (71)
- Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (1991) (71)
- Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. (2003) (70)
- Selective suppression of the transcription of ribosomal genes in mouse‐human hybrid cells (1979) (69)
- Pluripotent stem cell miRNAs and metastasis in invasive breast cancer. (2014) (68)
- Potential cancer therapy with the fragile histidine triad gene: review of the preclinical studies. (2001) (68)
- Expression of H–2, laminin and SV40T and TASA on differentiation of transformed murine teratocarcinoma cells (1980) (67)
- Wwox and Ap2γ Expression Levels Predict Tamoxifen Response (2007) (65)
- The AKT1 proto-oncogene maps to human chromosome 14, band q32. (1988) (65)
- The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B. (1997) (65)
- Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity (2007) (64)
- Loss of FHIT expression in transitional cell carcinoma of the urinary bladder. (2000) (64)
- Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis (2009) (63)
- Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential (2006) (63)
- FHIT in human cancer. (1998) (62)
- The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. (2002) (62)
- Characterization of the human PIM-1 gene: a putative proto-oncogene coding for a tissue specific member of the protein kinase family. (1987) (61)
- The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas. (1996) (60)
- TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation. (2015) (60)
- Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13. (1987) (60)
- Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. (1995) (60)
- The gene encoding the T-cell surface protein T4 is located on human chromosome 12. (1986) (59)
- FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs (2014) (59)
- cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src). (1991) (59)
- The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers. (1999) (59)
- Characterization of the Complete Genomic Structure of the Human WNT-5A Gene, Functional Analysis of its Promoter, Chromosomal Mapping, and Expression in Early Human Embryogenesis (*) (1995) (59)
- Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss‐induced global genome instability (2013) (58)
- Chromosome locations of human EMX and OTX genes. (1994) (58)
- Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant (2004) (57)
- The alpha-spectrin gene is on chromosome 1 in mouse and man. (1985) (57)
- Localization of the gene for the erythroid anion exchange protein, band 3 (EMPB3), to human chromosome 17. (1987) (57)
- Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: Evolutionarily conserved but highly recombinogenic (2003) (57)
- Pathology and biology associated with the fragile FHIT gene and gene product (2010) (56)
- Regression of upper gastric cancer in mice by FHIT gene delivery (2003) (55)
- Involvement of the Fhit gene in the ionizing radiation‐activated ATR/CHK1 pathway (2005) (55)
- Mapping of four distinct BCR-related loci to chromosome region 22q11: order of BCR loci relative to chronic myelogenous leukemia and acute lymphoblastic leukemia breakpoints. (1987) (53)
- Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas. (1999) (53)
- Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines. (1988) (52)
- Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus (1990) (52)
- Fhit and CHK1 have opposing effects on homologous recombination repair. (2005) (52)
- B-raf and a B-raf pseudogene are located on 7q in man. (1992) (52)
- Chromosomal location of murine and human IL-1 receptor genes. (1991) (52)
- Localization of the human JUN protooncogene to chromosome region 1p31-32. (1988) (51)
- Fhit modulates the DNA damage checkpoint response. (2006) (49)
- Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors (1998) (49)
- Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination. (2009) (49)
- Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features (2011) (49)
- Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. (1996) (49)
- DNA-transformed murine teratocarcinoma cells: regulation of expression of simian virus 40 tumor antigen in stem versus differentiated cells. (1980) (48)
- Fhit expression in gastric adenocarcinoma (2000) (48)
- Characterization of the receptor protein tyrosine phosphatase gene product PTP gamma: binding and activation by triphosphorylated nucleosides. (1995) (47)
- Human genes other than CD4 facilitate HIV-1 infection of murine cells. (1991) (47)
- Fhit tumor suppressor: guardian of the preneoplastic genome. (2008) (47)
- p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. (2003) (46)
- Biological Functions of Mammalian Nit1, the Counterpart of the Invertebrate NitFhit Rosetta Stone Protein, a Possible Tumor Suppressor* (2006) (46)
- WWOX: A fragile tumor suppressor (2015) (45)
- The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. (1994) (45)
- Fragile histidine triad protein, WW domain‐containing oxidoreductase protein Wwox, and activator protein 2γ expression levels correlate with basal phenotype in breast cancer (2009) (45)
- FHIT as Tumor Suppressor: Mechanisms and Therapeutic Opportunities (2002) (44)
- Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression. (2000) (44)
- Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53−/− mice (2001) (44)
- The gene encoding human vimentin is located on the short arm of chromosome 10. (1987) (43)
- A Fhit-ing Role in the DNA Damage Checkpoint Response (2007) (43)
- Order of genes on human chromosome 5q with respect to 5q interstitial deletions. (1990) (43)
- Wwox and Ap2gamma expression levels predict tamoxifen response. (2007) (42)
- Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. (1996) (41)
- Involvement of the ALL-1 gene in a solid tumor. (1995) (41)
- A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. (1992) (41)
- Cloning and chromosomal localization of a human endothelin ETA receptor. (1991) (41)
- Chromosomal localization of the human genes for lipocortin I and lipocortin II. (1988) (40)
- Stem cell-related markers in primary breast cancers and associated metastatic lesions (2012) (40)
- Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats. (2000) (40)
- Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22. (1994) (40)
- Tumor suppressors on 3p: A neoclassic quartet (2001) (39)
- Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. (1997) (39)
- Histone H1 Phosphorylation in Breast Cancer (2014) (39)
- Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19. (1990) (39)
- Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein. (1997) (39)
- Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. (2005) (39)
- Molecular anatomy of a 5q interstitial deletion. (1990) (38)
- Molecular parameters of genome instability: Roles of fragile genes at common fragile sites (2008) (38)
- Molecular cloning and characterization of a cDNA for human granulocyte colony-stimulating factor (G-CSF) from a glioblastoma multiforme cell line and localization of the G-CSF gene to chromosome band 17q21. (1987) (38)
- Familial uveal melanoma: absence of germline mutations involving the cyclin-dependent kinase-4 inhibitor gene (p16). (1996) (37)
- Fragile gene product, Fhit, in oxidative and replicative stress responses (2009) (37)
- Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells (2008) (37)
- Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. (1991) (37)
- FHITness and cancer. (1998) (36)
- Wwox–Brca1 interaction: role in DNA repair pathway choice (2016) (36)
- FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension (2019) (36)
- The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13. (1993) (35)
- Localization of the gene encoding human erythroid-potentiating activity to chromosome region Xp11.1----Xp11.4. (1986) (35)
- Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20 (1989) (34)
- The role of deletions at the FRA3B/FHIT locus in carcinogenesis. (1998) (34)
- Chromosome localization of human ARH genes, a ras-related gene family. (1990) (34)
- Human homologue of Moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3' of the myc gene, is rearranged in multiple myelomas. (1990) (33)
- Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. (2005) (33)
- PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3. (1996) (33)
- The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells. (1998) (33)
- Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2). (1994) (33)
- Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells (2019) (32)
- A rearranged transforming gene, tre, is made up of human sequences derived from chromosome regions 5q, 17q and 18q. (1988) (32)
- Hits, Fhits and Nits: beyond enzymatic function. (2011) (32)
- Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. (2005) (32)
- Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22. (1992) (31)
- The translocated c-myc oncogene of Raji Burkitt lymphoma cells is not expressed in human lymphoblastoid cells. (1985) (31)
- Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. (2011) (30)
- 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. (2004) (30)
- A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells. (1993) (30)
- Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis. (2003) (30)
- Lineage-specific gene rearrangement/deletion: a nonconservative model. (1989) (30)
- Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling (2007) (30)
- cDNA cloning and chromosomal localization of the human α‐adrenergic receptor kinase (1991) (30)
- The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2. (1988) (30)
- Fhit Interaction with Ferredoxin Reductase Triggers Generation of Reactive Oxygen Species and Apoptosis of Cancer Cells* (2008) (30)
- Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers (2017) (29)
- Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation (2001) (29)
- FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis (2014) (29)
- Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione (2017) (29)
- Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript. (1988) (29)
- The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. (1993) (28)
- Correlation of Fragile Histidine Triad (Fhit) Protein Structural Features with Effector Interactions and Biological Functions* (2009) (28)
- CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors (2004) (28)
- Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24. (1994) (28)
- Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25. (1985) (28)
- Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion (2013) (28)
- Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis (2014) (27)
- Receptor Protein Tyrosine Phosphatase Gamma, Ptpγ, Regulates Hematopoietic Differentiation (1997) (26)
- Protein Expression Profiling Identifies Cyclophilin A as a Molecular Target in Fhit-Mediated Tumor Suppression (2006) (26)
- Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice (2004) (26)
- The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function (2003) (26)
- Chromosomal localization of two human zinc finger protein genes, ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12, respectively. (1991) (26)
- Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer. (2003) (25)
- Chromosomal localization of a human band 3-like gene to region 7q35----7q36. (1986) (25)
- The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation (2001) (25)
- Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34 (1992) (25)
- FLT4 Receptor Tyrosine Kinase Gene Mapping to Chromosome Band 5q35 in Relation to the t(2;5), t(5;6), and t(3;5) Translocations (1993) (25)
- A human ADP/ATP translocase gene has seven pseudogenes and localizes to chromosome X (1990) (24)
- Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer. (2000) (24)
- Common fragile genes. (2004) (24)
- Nit1 and Fhit tumor suppressor activities are additive (2009) (24)
- Characterization of the role of Fhit in suppression of DNA damage. (2013) (23)
- Coexpression of translocated and normal c-myc oncogenes in hybrids between Daudi and lymphoblastoid cells. (1985) (23)
- Localization of 11q13 loci with respect to regional chromosomal breakpoints. (1992) (23)
- Impact of FHIT loss on the translation of cancer-associated mRNAs (2017) (21)
- Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. (2008) (21)
- Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. (2017) (21)
- Response of subtype‐specific human breast cancer‐derived cells to poly(ADP‐ribose) polymerase and checkpoint kinase 1 inhibition (2011) (21)
- Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: Evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival (2000) (21)
- Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas. (2007) (21)
- Fusion of the bcr and the c-abl genes in Ph'-positive acute lymphocytic leukemia with no rearrangement in the breakpoint cluster region. (1988) (20)
- Coordinate Loss of Fragile Gene Expression in Pancreatobiliary Cancers: Correlations Among Markers and Clinical Features (2009) (20)
- Loss of FHIT expression in acute lymphoblastic leukemia. (1999) (20)
- Loss or reduction of Fhit expression in renal neoplasias: correlation with histogenic class. (1999) (20)
- Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer (2010) (20)
- Chromosomal locations of mouse immunoglobulin genes. (1978) (20)
- Receptor protein tyrosine phosphatase gamma, Ptp gamma, regulates hematopoietic differentiation. (1997) (19)
- Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains. (2011) (19)
- The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25. (1993) (19)
- Genetics of cell transformation by simian virus 40. (1975) (19)
- Von Hippel-Lindau disease: identification of deletion mutations by pulsed-field gel electrophoresis (1993) (19)
- Localization of the fibroblast growth factor receptor‐4 gene to chromosome region 5q33‐qter (1992) (19)
- Rescue of defective SV40 from mouse-human hybrid cells containing human chromosome 7. (1974) (19)
- Losses at 3p common deletion sites in subtypes of kidney tumours: histopathological correlations (1996) (18)
- Suppression of replication of SV40 and polyoma virus in mouse-human hybrids (1977) (18)
- The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter (1987) (17)
- Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. (1992) (16)
- The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (1992) (16)
- Molecular Cloning and Characterization of an Antigen Associated with Early Stages of Melanoma Tumor Progression 1 (2006) (16)
- Preclinical Assessment of FHIT Gene Replacement Therapy in Human Leukemia Using a Chimeric Adenovirus, Ad5/F35 (2006) (15)
- Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch. (2017) (15)
- Abrogation of esophageal carcinoma development in miR-31 knockout rats (2020) (15)
- Chromosomal locations of members of a family of novel endogenous human retroviral genomes (1986) (15)
- Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses. (2004) (15)
- The ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deleted FHIT alleles (2017) (15)
- Characterization of defective SV40 isolated from SV40-transformed cells. (1975) (14)
- FHIT gene expression in human urinary bladder transitional cell carcinomas. (2001) (14)
- FHIT RNA and protein expression in oral squamous cell carcinomas. (2001) (14)
- The human platelet-derived growth factor α chain (PDGFA) gene maps to chromosome 7p22 (1992) (13)
- Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression. (2017) (13)
- Chromosome locations of the MYB related genes, AMYB and BMYB. (1991) (13)
- Exome‐wide single‐base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse (2016) (13)
- Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6. (1995) (13)
- Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats (2018) (13)
- Phospholipase C γ-2 (Plcg2) and phospholipase C γ-1 (Plcg1) map to distinct regions in the human and mouse genomes (1995) (13)
- Suppression of the normal mouse c-myc oncogene in human lymphoma cells (1985) (12)
- A murine teratocarcinoma stem cell line carries suppressed oncogenic virus genomes (1979) (12)
- Reassignment of the human ARH9 RAS-related gene to chromosome 1p13-p21. (1993) (12)
- YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. (1993) (12)
- Molecular genetic analysis in the diagnosis of lymphoma in fine needle aspiration biopsies. I. Lymphomas versus benign lymphoproliferative disorders. (1988) (11)
- Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14 (1990) (11)
- Chromosome assignment of the T-antigen gene of simian virus 40 in African green monkey cells transformed by adeno 7-SV40 hybrid. (1974) (11)
- Deoxyribonuclease I sensitivity of plasmid genomes in teratocarcinoma-derived stem and differentiated cells. (1981) (11)
- Isolation of defective viruses from SV40-transformed human and hamster cells. (1974) (10)
- Chromosome sublocalization of a cDNA for human DNA polymerase-β to 8p11→p12 (1988) (10)
- p380-8A 1.8 SaSs, a single copy clone 5' of c-myc at 8q24 which recognizes an SstI polymorphism. (1987) (10)
- Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland. (2010) (10)
- The human VpreB gene is located on chromosome 22 near a cluster of $${\text{V}}_{\lambda _1 } $$ gene segments (2004) (10)
- Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (1995) (10)
- Transcription of the simian virus 40 genome in DNA-transformed murine teratocarcinoma stem cells. (1981) (10)
- Assignment of the gene (EPLG2) encoding a high-affinity binding protein for the receptor tyrosine kinase elk to a 200-kilobasepair region in human chromosome Xq12. (1995) (10)
- Genotypic analysis of DNA isolated from fine needle aspiration biopsies. (1988) (9)
- Fhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation. (2010) (9)
- The human gene encoding phosphatidylinositol-3 kinase associated p85 alpha is at chromosome region 5q12-13. (1991) (9)
- Fhit protein expression in hereditary and sporadic colorectal cancers. (2001) (9)
- Hypermethylation patterns in the Fhit regulatory region are tissue specific (2005) (9)
- Chromosomal localization of human genes required for G1 progression in mammalian cells. (1989) (9)
- Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. (2009) (8)
- The human homologue of the retroviral oncogene qin maps to chromosome 14q13. (1994) (8)
- Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats (2004) (8)
- Two human genes encoding zinc finger proteins, ZNF12 (KOX 3) and ZNF 26 (KOX 20), map to chromosomes 7p22-p21 and 12q24.33, respectively (1991) (7)
- Fhit loss‐associated initiation and progression of neoplasia in vitro (2016) (7)
- Molecular biology: DNA fragility put into context (2011) (7)
- Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation (2016) (7)
- Detection of specific genetic alterations in cancer cells. (1996) (7)
- RFLPs in the fibroblast growth factor receptor-4 locus (FGFR4) in 5q33-qter. (1991) (7)
- Characterization of human bone marrow‐derived closed circular DNA clones (1993) (7)
- Molecular genetic analysis in the diagnosis of lymphoma in fine needle aspiration biopsies. II. Lymphomas versus nonlymphoid malignant tumors. (1988) (6)
- The human VAV proto-oncogene maps to chromosome region 19p12→19p13.2 (1990) (6)
- The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22. (1992) (6)
- Expression of fhit protein during mouse development (2000) (6)
- Loss of fragile histidine triad (Fhit) protein expression alters the translation of cancer-associated mRNAs (2018) (6)
- Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes. (1995) (6)
- Localization of the human HF.10 finger gene on a chromosome region (3p21–22) frequently deleted in human cancers (1990) (5)
- Production of B-tropic murine leukemia virus by somatic cell hybrids between mouse peritoneal macrophages and simian virus 40-transformed human cells (1976) (5)
- Southern blot analysis of BII cell line--a putative variant of HL-60. (1987) (5)
- Fhit protein expression in oral epithelium: immunohistochemical evaluation of three antisera. (2001) (5)
- Deficiency Accelerates Induction and Progression of Esophageal and Forestomach Tumors in Zinc-deficient Mice 1 (2002) (4)
- Fhit down-regulation is an early event in pancreatic carcinogenesis (2017) (4)
- Control of expression of histocompatibility antigens ( H-2 ) and ( 32-microglobulin in F 9 teratocarcinoma stem cells ( surface antigens / gene transcription / DNase I / cell differentiation ) (4)
- Chromosomal localization of four human zinc finger cDNAs (1993) (4)
- Synthesis of SV40 capsid antigen(s) in heterokaryocytes formed by fusion of nonpermissive with permissive cells. (1974) (4)
- Chromosomal proteins of mouse teratocarcinoma cells (1982) (3)
- Fhit protein expression in endometrial cancers: no correlation with histological grade. (2001) (3)
- Combined Cyclin D 1 Overexpression and Zinc Deficiency Disrupts Cell Cycle and Accelerates Mouse Forestomach Carcinogenesis 1 (2003) (3)
- Associated with Early Stages of Melanoma Tumor Progression Molecular Cloning and Characterization of an Antigen Updated (2006) (3)
- 4-HYDROXYBUTYL(BUTYL)NITROSAMINE (OH-BBN)- INDUCED URINARY BLADDER CANCERS IN MICE: CHARACTERIZATION OF FHIT, SURVIVIN AND COX-2 EXPRESSION AND CHEMOPREVENTIVE EFFECTS OF INDOMETHACIN (2004) (2)
- Effect of zinc supplementation on N -nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains (2011) (2)
- Previously unreported NcoI RFLP for human CSF1R. (1989) (2)
- Discussion on the use of taxanes for treatment of breast cancers in BRCA1 mutations carriers (2007) (2)
- Abnormalities of chromosome 5q correlate with morphologic features of better prognosis in clear cell renal carcinomas. (1995) (1)
- Mapping of 22Notl linking clones on human chromosome 3 by polymerase chain reaction and somatic cell hybrid panels (2005) (1)
- Gene expression profiles in zinc-deficient versus zinc replenished rat esophagus (2004) (1)
- Influence of a nonfragile FHIT transgene on murine tumor susceptibility (2007) (1)
- SstI polymorphism revealed by anonymous probe cpl 2.6 [D5S89] which maps to 5q21----5q31. (1989) (1)
- Use of microRNA (miR) expression profiling to identify distinct subclasses of triple-negative breast cancers (TNBC). (2012) (1)
- Chromosome sublocalization of a cDNA for human DNA polymerase-beta to 8p11----p12. (1988) (1)
- A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene. (1993) (1)
- Correction for Gasparini et al., Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation (2017) (1)
- FHIT (fragile histidine triad) (2011) (1)
- Environmental factors may regulate BCL2 associated lymphomagenesis: a very low incidence of BCL2-MBR translocation in Poland. (1995) (1)
- Germ line configuration of the BCL-2 major breakpoint region in hyperplastic lymph nodes. (1991) (1)
- Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination. (2021) (1)
- 871 Deficiency of the WWOX Fragile Gene Impairs DNA Damage Response (2010) (0)
- Helping the hypermutator: The Fhit-APOBEC connection (2015) (0)
- 586 The role of FHIT gene in lung carcinogenesis (1997) (0)
- SUBSTRATE ANALOG (IB2) COMPLEX WITH THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT (1998) (0)
- 426 Distinct MiRNA Expression Patterns in Among Breast Tumors of Patients Carried and Non-carried Germ-line BRCA Mutations (2012) (0)
- The FHIT gene product: tumor suppressor and genome “caretaker” (2014) (0)
- Identification of Products Encoded by NK Cell-Derived cDNA Clones (1990) (0)
- Chromosome Fragile Sites Signature and Genome Instability in Human Epithelial cells (2013) (0)
- CARRIES SUPPRESSED ONCOGENIC VIRUS GENOMES (1979) (0)
- Regulation of the Expression of SV40 T Antigen in Stem Versus Differentiated Cells (1980) (0)
- Short Communication Loss of FHIT Expression in Transitional Cell Carcinoma of the Urinary Bladder (2000) (0)
- Loss of F HIT Expression in Gastric Carcinoma 1 (2006) (0)
- DNA Damage-Associated Proteins in Triple Negative Breast Cancers (2010) (0)
- Advances in Brief Rarity of Somatic and Gennline Mutations of the Cydin-dependent Kinase 4 Inhibitor Gene , CDK 4 I , in Melanoma ' (0)
- Sv 40 rescue in hetero karyocytes respective roles of nonpermissive transformed cell and permissive cell (1973) (0)
- Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice (2022) (0)
- Advances in Brief A Homozygous Deletion within the Carbonic Anhydrase-like Domain of the Ptprg Gene in Murine L-Cells 1 (2006) (0)
- 543 Analysis of FHIT gene alterations in primary tumours, bronchial mucosa biopsies and sputum specimens from lung cancer patients (1997) (0)
- WWOX (WW domain containing oxidoreductase) (2008) (0)
- Correction to: Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential (2022) (0)
- Carbonic Anhydrase-Like Domain in the Extracellular Region of RPTP-y Defines a New Subfamily (0)
- Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1 q 21 ( expression library / polyprotein repeat / polymorphism / in situ hybridization ) (0)
- Editorial Expression of Concern: WWOX gene restoration prevents lung cancer growth in vitro and in vivo (2017) (0)
- in myeloid leukemia in BXH-2 mice. Meis1, a PBX1-related homeobox gene involved (2013) (0)
- Molecular Anatomy of a 5 q Interstitial Deletion (2003) (0)
- Abstract B62: Zinc supplementation reduces forestomach tumor burden in N-nitrosomethylbenzylamine-treated mice (2010) (0)
- WWOX-deficiency promotes increased survival by enhancing homology-directed repair (2017) (0)
- Corrigendum to “Fhit loss in lung preneoplasia: Relation to DNA damage response checkpoint activation” [Cancer Lett. 291 (2) (2010) 230–236] (2015) (0)
- Expression of late viral functions in SV40-infected rat-monkey somatic cell hybrids (1979) (0)
- Abstract B64: Zinc supplementation has antitumor effects in 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis (2010) (0)
- Inhibitionof Breast Cancer Cell Growth In vitro and In vivo : Effect of Restoration ofWwox Expression (2006) (0)
- 544 Abnormal structure, transcription and expression of the FHIT gene in lung cancer cell lines (1997) (0)
- Activation ofMultiple GenesbyProvirus Integration intheMlvi-4 LocusinT-Cell Lymphomas Induced byMoloney Murine Leukemia Virus (1990) (0)
- Activity of X-linked genes in stem and differentiated Mus musculus X Mus caroli hybrid cells. (1984) (0)
- Involvement of the ALLI gene in a solid tumor ( chromosomal translocations / self-fusion ) (2005) (0)
- Altered Expression of FHIT in Esophageal Neoplasm (2002) (0)
- Gene rearrangements detected by nonradioactive digoxigenin-labeled DNA probes. (1991) (0)
- Homozygous mutations in the Fhit gene results in resistance to ionizing radiation and inhibition of apoptosis (2001) (0)
- Characterization of a Fhit protein complex suggests a novel pathway to apoptosis of cancer cells (2007) (0)
- Advances in Brief Cloning of the ALL . 1 Fusion Partner , the AF-6 Gene , Involved in Acute Myeloid Leukemias with the t ( 6 ; ll ) Chromosome (2007) (0)
- The Murine F hit Locus: Isolation, Characterization, and Expression in Normal and Tumor Cells1 (2006) (0)
- Fhit loss in familial breast cancer: is loss of DNA repair function linked to alterations at chromosome fragile sites? (2001) (0)
- (myeloid leukemia/chromosome translocation/p53/in situ hybridization) (2016) (0)
- Chromosomal Locations ofMembersofaFamily ofNovel Endogenous HumanRetroviral Genomes (1986) (0)
- Aberrant FHIT Transcripts in Merkel Cell Carcinoma1 (2006) (0)
- Multifaceted assessment of genetic alterations in oralcancer (1997) (0)
- Correction: Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential (2019) (0)
- Impact of FHIT loss on the translation of cancer-associated mRNAs (2017) (0)
- Decreased tumorigenicity of lung cancer cells by minimal Fhit expression (2005) (0)
- Loss of fragile histidine triad (Fhit) protein expression alters the translation of cancer-associated mRNAs (2018) (0)
- A NovelEndothelial CellSurface Receptor Tyrosine Kinase withExtracellular Epidermal GrowthFactor Homology Domains (1992) (0)
- Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells (2019) (0)
- Non-isotopic procedure with silver staining of polyacrylamide gels in detection of genomic abnormalities in tumors using microsatellites. (1995) (0)
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