Kazuo Sugamura

Q: What Schools Are Affiliated With Kazuo Sugamura

Kazuo Sugamura is affiliated with the following schools: Tohoku University, Juntendo University, Osaka University, Nara Medical University, Kyoto University

Kazuo Sugamura's AcademicInfluence.com Rankings

Kazuo Sugamura

Philosophy

#8101

World Rank

#11420

Historical Rank

Logic

#5132

World Rank

#6502

Historical Rank

philosophy Degrees

Kazuo Sugamura

Biology

#10937

World Rank

#14302

Historical Rank

Immunology

#696

World Rank

#718

Historical Rank

biology Degrees

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Philosophy
Biology

Kazuo Sugamura's Degrees

PhD Immunology University of Tokyo
Doctorate Medicine University of Tokyo

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Kazuo Sugamura's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. (2002) (1312)
Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2 (2001) (1069)
Cloning of the gamma chain of the human IL-2 receptor. (1992) (769)
Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. (1993) (742)
Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex1 (2001) (577)
The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. (1996) (434)
Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines (2000) (416)
Selective expression of a novel surface molecule by human Th2 cells in vivo. (1999) (395)
Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. (1994) (360)
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40 (2004) (347)
Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand (2000) (344)
Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells1 (2004) (315)
Clathrin-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus into Target Cells Expressing ACE2 with the Cytoplasmic Tail Deleted (2007) (313)
CRTH2, an orphan receptor of T‐helper‐2‐cells, is expressed on basophils and eosinophils and responds to mast cell‐derived factor(s) (1999) (301)
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility (2005) (286)
Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. (1996) (277)
Human parvovirus B19 as a causative agent for rheumatoid arthritis. (1998) (266)
Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice. (2010) (263)
Human Parvovirus B19 Nonstructural (NS1) Protein Induces Apoptosis in Erythroid Lineage Cells (1998) (262)
c-myc Is a Downstream Target of the Smad Pathway* 210 (2002) (254)
During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8+ Memory T Cells and Their Capacity for Secondary Expansion1 (2005) (250)
NOD / SCID / cnull mouse : an excellent recipient mouse model for engraftment of human cells (2002) (248)
Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat (1989) (239)
Enhanced Expression of Long Non-Coding RNA HOTAIR Is Associated with the Development of Gastric Cancer (2013) (235)
Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice (1997) (220)
Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. (2010) (218)
Important Role of Endogenous Erythropoietin System in Recruitment of Endothelial Progenitor Cells in Hypoxia-Induced Pulmonary Hypertension in Mice (2006) (204)
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads (2001) (200)
Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule (1997) (197)
The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). (2009) (197)
Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets (2000) (194)
Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor1 (2006) (190)
Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA (2000) (190)
Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T‐cell leukemia virus (1984) (190)
Important Role of Erythropoietin Receptor to Promote VEGF Expression and Angiogenesis in Peripheral Ischemia in Mice (2007) (179)
A cytotoxic nonstructural protein, NS1, of human parvovirus B19 induces activation of interleukin-6 gene expression (1996) (171)
Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex (1994) (167)
The Common γ-Chain for Multiple Cytokine Receptors (1995) (165)
High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells (1986) (160)
STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. (1997) (158)
Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer (2014) (154)
Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4 (2002) (152)
Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common gamma chain. (1996) (149)
IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection. (1996) (149)
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma (2003) (148)
Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor (1989) (148)
Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases (1998) (148)
Propagation of human parvovirus B19 in primary culture of erythroid lineage cells derived from fetal liver (1989) (146)
Healthy carriers of a human retrovirus, adult T-cell leukemia virus (ATLV): demonstration by clonal culture of ATLV-carrying T cells from peripheral blood. (1982) (141)
Possible Involvement of a Novel STAM-associated Molecule “AMSH” in Intracellular Signal Transduction Mediated by Cytokines* (1999) (132)
Constitutive OX40/OX40 Ligand Interaction Induces Autoimmune-Like Diseases1 (2002) (131)
Human Parvovirus B19 Induces Cell Cycle Arrest at G2 Phase with Accumulation of Mitotic Cyclins (2001) (131)
Activation of natural killer cells via the p75 interleukin 2 receptor (1989) (128)
Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection (2009) (128)
Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT (1999) (125)
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. (2010) (125)
Critical Involvement of OX40 Ligand Signals in the T Cell Priming Events During Experimental Autoimmune Encephalomyelitis1 (2001) (123)
An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex. (1992) (123)
Parvovirus B19 and the pathogenesis of anaemia (2003) (122)
Differential expression of the IL-2 receptor subunits, p55 and p75 on various populations of primary peripheral blood mononuclear cells. (1989) (121)
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. (2007) (120)
Accumulation of CD16-CD56+ natural killer cells with high affinity interleukin 2 receptors in human early pregnancy decidua. (1991) (118)
Establishment of human cytotoxic T cell lines specific for human adult T cell leukemia virus-bearing cells. (1983) (118)
The incidence of, and factors leading to, parvovirus B19-related hydrops fetalis following maternal infection; report of 10 cases and meta-analysis. (1998) (117)
Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. (2006) (116)
Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway1 (2008) (115)
Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways. (1993) (115)
Expression and role of p75 interleukin 2 receptor on human monocytes (1990) (112)
A retrovirus associated with human adult T-cell leukemia: in vitro activation. (1982) (109)
Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. (1997) (105)
Expression of the IL-2 receptor γ chain on various populations in human peripheral blood (1994) (103)
Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway. (2012) (100)
gamma-c gene transfer into SCID X1 patients' B-cell lines restores normal high-affinity interleukin-2 receptor expression and function. (1996) (100)
OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity1 (2006) (98)
Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts. (2004) (96)
Human Parvovirus B19 Nonstructural Protein (NS1) Induces Cell Cycle Arrest at G1 Phase (2003) (95)
Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family. (1999) (89)
Primary infection of Japanese infants with adult T-cell leukaemia-associated retrovirus (ATLV): evidence for viral transmission from mothers to children. (1986) (88)
Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1. (2009) (88)
Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines (2010) (84)
Identification of two distinct elements in the long terminal repeat of HTLV‐I responsible for maximum gene expression. (1987) (84)
c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130 (2008) (84)
Granulysin in human serum as a marker of cell‐mediated immunity (2003) (84)
Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane (2000) (84)
Electroporation: application to human lymphoid cell lines for stable introduction of a transactivator gene of human T-cell leukemia virus type I. (1989) (83)
Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. (1995) (79)
Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency. (1994) (78)
Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse. (2012) (78)
Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation. (2003) (78)
Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (1996) (77)
Survival of parvovirus B19-infected cells by cellular autophagy. (2006) (75)
Specific cytolysis of fresh tumor cells by an autologous killer T cell line derived from an adult T cell leukemia/lymphoma patient. (1984) (74)
OX40 Costimulatory Signals Potentiate the Memory Commitment of Effector CD8+ T Cells1 (2008) (73)
Retroviral-mediated gene correction for X-linked severe combined immunodeficiency. (1996) (73)
Interleukin 2 (IL-2) receptor expression and sensitivity to diphteria fusion toxin DAB389IL-2 in cultured hematopoietic cells. (1996) (70)
Immortalization of BGDF (BCGF II)- and BCDF-producing T cells by human T cell leukemia virus (HTLV) and characterization of human BGDF (BCGF II). (1985) (69)
Rheumatoid arthritis after human parvovirus B19 infection (1999) (69)
STAM2, a new member of the STAM family, binding to the Janus kinases (2000) (69)
Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. (1999) (69)
Role of Hrs in maturation of autophagosomes in mammalian cells. (2007) (68)
Parvovirus B19 infection induces apoptosis of erythroid cells in vitro and in vivo. (1999) (66)
Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets. (2007) (65)
Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains. (1994) (65)
Activation of peripheral blood T cells via the p75 interleukin 2 receptor (1989) (65)
Grb2 and Gads Exhibit Different Interactions with CD28 and Play Distinct Roles in CD28-Mediated Costimulation1 (2006) (65)
OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses (2003) (64)
An associated molecule, p64, with high-affinity interleukin 2 receptor. (1990) (63)
Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75 [published erratum appears in J Exp Med 1990 Jun 1;171(6):2183] (1990) (62)
Functional CD4 T Cells after Intercellular Molecular Transfer of OX40 Ligand1 (2001) (60)
Interleukin 2‐induced activation of JAK3: Possible involvement in signal transduction for c‐myc induction and cell proliferation (1994) (60)
Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non‐endosomal functions (2008) (60)
Serologic study of human parvovirus B19 infection in pregnancy in Japan. (1999) (59)
Differential Requirements for OX40 Signals on Generation of Effector and Central Memory CD4+ T Cells1 (2007) (58)
Increased expression of the interleukin 2 (IL-2) receptor beta chain (p70) on CD56+ natural killer cells after in vivo IL-2 therapy: p70 expression does not alone predict the level of intermediate affinity IL- 2 binding (1990) (58)
AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes. (2007) (58)
Inhibition of Tumor Growth and Metastasis by Depletion of Vesicular Sorting Protein Hrs: Its Regulatory Role on E-Cadherin and β-Catenin (2007) (57)
Dispensability of Jak1 tyrosine kinase for interleukin‐2‐induced cell growth signaling in a human T cell line (1996) (57)
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo. (1995) (55)
Human Retroviruses: HTLV-I and HTLV-II (1993) (54)
Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis (2004) (53)
CD271 Defines a Stem Cell-Like Population in Hypopharyngeal Cancer (2013) (53)
Hrs, a Mammalian Master Molecule in Vesicular Transport and Protein Sorting, Suppresses the Degradation of ESCRT Proteins Signal Transducing Adaptor Molecule 1 and 2* (2005) (53)
Induction of OX40, a Receptor of gp34, on T Cells by Trans‐acting Transcriptional Activator, Tax, of Human T‐Cell Leukemia Virus Type I (1996) (52)
Loss of Hippocampal CA3 Pyramidal Neurons in Mice Lacking STAM1 (2001) (52)
The common gamma-chain for multiple cytokine receptors. (1995) (52)
Consequences of OX40‐OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L‐transgenic mice (2002) (52)
Expression of the mouse interleukin‐2 receptor γ chain in various cell populations of the thymus and spleen (1994) (51)
Persistent infection of human parvovirus B19 in a normal subject (1995) (51)
Signal-Transducing Adaptor Molecules STAM1 and STAM2 Are Required for T-Cell Development and Survival (2002) (51)
Regulation by interleukin-2 (IL-2) and interferon gamma of IL-2 receptor gamma chain gene expression in human monocytes. (1994) (51)
Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration. (2008) (51)
Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. (1993) (50)
Interleukin (IL)-15 Promotes the Growth of Murine Epidermal γδ T Cells by a Mechanism Involving the β- and γc-Chains of the IL-2 Receptor (1995) (49)
The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit. (1992) (49)
Loss of Neurons in the Hippocampus and Cerebral Cortex of AMSH-Deficient Mice (2001) (47)
Interleukin‐4 inhibits χ light chain expression and NFχB activation but not IχBα degradation in 70Z/3 murine pre‐B cells (1995) (46)
Retrovirus-induced expression of interleukin 2 receptors on cells of human B-cell lineage. (1984) (46)
Development of a Multi-Step Leukemogenesis Model of MLL-Rearranged Leukemia Using Humanized Mice (2012) (45)
An association between human parvovirus B-19 infection and autoantibody production. (1989) (45)
The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowel disease in Janus family tyrosine kinase 3(-/-) and IL-2 receptor gamma(-/-) mice. (2002) (45)
Clinical manifestations and outcomes of parvovirus B19 infection during pregnancy in Japan. (2006) (45)
Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones (2001) (45)
Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat. (1997) (44)
Molecular Mechanisms of Promoter Regulation of the gp34 Gene That Is Trans-activated by an Oncoprotein Tax of Human T Cell Leukemia Virus Type I* (1998) (43)
Human parvovirus B19 nonstructural protein (NS1) induces cell cycle arrest at G(1) phase. (2003) (43)
Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and beta-catenin. (2007) (41)
OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization. (2010) (41)
Identification of a glycoprotein, gp21, of adult T cell leukemia virus by monoclonal antibody. (1984) (40)
Differences in the interleukin‐2 (IL‐2) receptor system in human and mouse: α chain is required for formation of the functional mouse IL‐2 receptor (1995) (40)
A novel human tyrosine kinase gene inducible in T cells by interleukin 2 (1993) (39)
Characterization of B-cell lines established from two X-linked severe combined immunodeficiency patients: interleukin-15 binds to the B cells but is not internalized efficiently. (1995) (39)
In vitro induction of cytotoxic T lymphocytes specific for Epstein-Barr virus-transformed cells: kinetics of autologous restimulation. (1980) (38)
Localization of an immunodominant domain on baculovirus-produced parvovirus B19 capsids: correlation to a major surface region on the native virus particle (1992) (38)
Functional Analysis of the Human Interleukin 2 Receptor γ Chain Gene Promoter (*) (1995) (38)
Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma (2014) (37)
trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein (1985) (37)
Functional role of interleukin-4 (IL-4) and IL-7 in the development of X-linked severe combined immunodeficiency. (1999) (37)
Memory of Epstein-Barr virus-specific cytotoxic T cells in normal seropostive adults as revealed by an in vitro restimulation method. (1980) (37)
Lack of intermediate‐affinity interleukin‐2 receptor in mice leads to dependence on interleukin‐2 receptor α, β and γ chain expression for T cell growth (1996) (36)
Expression of the interleukin-2 receptor gamma chain on cord blood mononuclear cells. (1996) (36)
Differential activation of the 21-base-pair enhancer element of human T-cell leukemia virus type I by its own trans-activator and cyclic AMP. (1989) (35)
Interleukin 2 inhibits in vitro growth of human T cell lines carrying retrovirus (1985) (35)
Identification of a soluble IL-2 receptor beta-chain from human lymphoid cell line cells. (1990) (35)
Expression of the common cytokine receptor γ chain by murine dendritic cells including epidermal Langerhans cells (1996) (35)
Establishment of human cell lines constitutively producing immune interferon: transformation of normal T cells by a human retrovirus. (1983) (35)
Human Parvovirus B19 nonstructural protein transactivates the p21/WAF1 through Sp1. (2004) (33)
Role of sendai virus fusion-glycoprotein in target cell susceptibility to cytotoxic T cells (1977) (33)
Detection of HTLV‐I Genome in Seronegative Infants Born to HTLV‐I Seropositive Mothers by Polymerase Chain Reaction (1989) (33)
Expanding role of T-cell costimulators in regulatory T-cell function: recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells. (2004) (33)
Protein phosphorylation mediated by IL-2/IL-2 receptor beta-chain interaction. (1988) (32)
Control of the IL-2 responsiveness of B lymphocytes by IL-2 and IL-4. (1995) (32)
Cooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits. (1994) (32)
IL‐2‐dependent in vivo and in vitro tyrosine phosphorylation of IL‐2 receptor γ chain (1992) (32)
Interleukin-2 receptor heterotrimer complex and intracellular signaling. (1993) (32)
Phage ϕC31 integrase‐mediated genomic integration of the common cytokine receptor gamma chain in human T‐cell lines (2006) (31)
Natural killer cells activated by interleukin 2 treatment in vivo respond to interleukin 2 primarily through the p75 receptor and maintain the p55 (TAC) negative phenotype. (1990) (31)
Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif. (2003) (31)
Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. (2003) (31)
A transgenic mouse model for non-immune hydrops fetalis induced by the NS1 gene of human parvovirus B19. (2002) (29)
Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation. (2010) (28)
Human parvovirus B19-induced cell cycle arrest and apoptosis (2002) (28)
Characterization of interleukin 2-stimulated phosphorylation of 67 and 63 kDa proteins in human T-cells. (1987) (28)
Involvement of fusion activity of ultraviolet light-inactivated sendai virus in formation of target antigens recognized by cytotoxic T cells (1978) (27)
OX40 and IL‐7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells (2014) (27)
Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common gamma chain. (1997) (27)
Suppression of thymic development by the dominant-negative form of Gads. (2001) (27)
Presence of a p70 IL-2-binding peptide on leukemic cells from various hemopoietic lineages. (1989) (27)
Identification of TL-Om1, an Adult T-Cell Leukemia (ATL) Cell Line, as Reference Material for Quantitative PCR for Human T-Lymphotropic Virus 1 (2014) (27)
Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor β-chain (2008) (26)
AMSH is required to degrade ubiquitinated proteins in the central nervous system. (2011) (26)
Heterogeneity of allogeneic restriction of human cytotoxic T cell clones specific for Epstein Barr virus. (1982) (25)
CD271 regulates the proliferation and motility of hypopharyngeal cancer cells (2016) (25)
Characterization of Monoclonal Antibodies against Human Parvovirus B19 (1989) (25)
Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines. (2006) (25)
Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway (2008) (25)
Human CD 4 1 central and effector memory T cells produce IL-21 : effect on cytokine-driven proliferation of CD 4 1 T cell subsets (2007) (24)
IL-2 receptor subunit, p75: direct demonstration of its IL-2 binding ability by using a novel monoclonal antibody. (1989) (24)
Aberrant Activation of the Interleukin-2 Autocrine Loop through the Nuclear Factor of Activated T Cells by Nonleukemogenic Human T-Cell Leukemia Virus Type 2 but Not by Leukemogenic Type 1 Virus (2005) (24)
A Novel Grb 2 Family Member , Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT (1999) (24)
Synergism between two distinct elements of the HTLV-I enhancer during activation by the trans-activator of HTLV-I. (1991) (24)
Differential expression of the interleukin 2 receptor beta (p75) chain on human peripheral blood natural killer subsets. (1990) (23)
In vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. (2010) (23)
Search for possible routes of vertical and horizontal transmission of adult T-cell leukemia virus. (1984) (23)
Generation of a syngeneic mouse model to study the intraperitoneal dissemination of ovarian cancer with in vivo luciferase imaging. (2009) (22)
Lack of dominant-negative effects of a truncated gamma(c) on retroviral-mediated gene correction of immunodeficient mice. (2001) (22)
Differential activity of dexamethasone on IL-2-, IL-4-, or IL-9-induced proliferation of murine factor-dependent T cell lines. (1996) (22)
Interleukin (IL)-15 promotes the growth of murine epidermal gamma delta T cells by a mechanism involving the beta- and gamma c-chains of the IL-2 receptor. (1995) (22)
Production of immune interferon by human cytotoxic T cell clones. (1982) (22)
Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin‐2 receptor γ chain‐deficient mice (1997) (21)
Expression of OX40 in muscles of polymyositis and granulomatous myopathy (2002) (21)
Kinetic study of interleukin‐2 binding on the reconstituted interleukin‐2 receptor complexes including the human γ chain (1993) (21)
Two distinct human cloned T cell lines that exhibit natural killer-like and anti-human effector activities. (1982) (20)
Implication of the common γ chain of the IL-7 receptor in intrathymic development of pro-T cells (1994) (20)
Co‐inhibitory roles for glucocorticoid‐induced TNF receptor in CD1d‐dependent natural killer T cells (2008) (20)
Phorbol esters can persistently replace interleukin‐2 (IL‐2) for the growth of a human IL‐2‐dependent T‐cell line (1988) (19)
New Monoclonal Antibodies That Define Multiple Epitopes and a Human‐Specific Marker on the Interleukin 2 Receptor Molecules of Primates (1986) (19)
The interleukin-2 receptor subunit expression and function on peripheral blood lymphocytes from HIV-infected and control persons. (1994) (18)
Update of CD antigens, 1996. (1997) (18)
Preferential utilization of the immature JH segment and absence of somatic mutation in the CDR3 junction of the Ig H chain gene in three X-linked severe combined immunodeficiency patients. (1994) (17)
HTLV-I Tax trans-activation and cell growth signaling. (1997) (17)
IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice. (1994) (17)
Novel receptor-mediated internalization of interleukin 2 in B cells. (1988) (17)
Microplate method for retrovirus-induced transformation of normal human T-cells. (1984) (17)
In vivo competitive studies between normal and common gamma chain-defective bone marrow cells: implications for gene therapy. (2000) (17)
High- and low-affinity interleukin 2 receptors: distinctive effects of monoclonal antibodies. (1986) (17)
Functional interleukin 2 receptors on B cells lacking Tac antigens (1987) (17)
trans-activation of the simian virus 40 enhancer by a pX product of human T-cell leukemia virus type I (1988) (17)
Essential Role of OX40L on B Cells in Persistent Alloantibody Production Following Repeated Alloimmunizations (2004) (16)
Enzyme-linked immunosorbent assay for IgG and IgM antibodies against human parvovirus B19: use of monoclonal antibodies and viral antigen propagated in vitro. (1989) (16)
Establishment of human cytotoxic T‐cell lines specific for epstein‐barr virus‐transformed autologous cells (1981) (16)
Human retrovirus in adult T-cell leukemia/lymphoma. (1985) (15)
T Cell Growth Factor from Human Splenic Cell Cultures: Conditions for Its Production, and Its Utilization for Maintenance of Cytotoxic T Cell Lines (1981) (15)
IL-2-induced signal transduction: involvement of tyrosine kinase and IL-2 receptor gamma chain. (1990) (15)
Expression of the IL-2 receptor gamma chain on various populations in human peripheral blood. (1994) (15)
Interleukin 2 (IL-2) rapidly induces phosphorylation of a cellular protein, pp67, in an IL-2 dependent murine cell line. (1986) (15)
Human parvovirus B19 in rheumatoid arthritis. (1998) (15)
Cell line-dependent response of the enhancer element of simian virus 40 to transactivator p40tax encoded by human T-cell leukemia virus type I. (1989) (15)
Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting* (2011) (14)
Acquired erythropoietin responsiveness of interleukin-2-dependent T lymphocytes retrovirally transduced with genes encoding chimeric erythropoietin/interleukin-2 receptors. (1995) (14)
Activation of leukemic large granular lymphocytes by interleukin-2 via the p75 interleukin-2 receptor. (1990) (14)
Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension (2011) (14)
Involvement of the interleukin‐2 receptor γ subunit in interleukin‐4‐dependent activation of mouse hematopoietic cells and splenic B cells (1995) (14)
Production of cytotoxic factor(s) in human T cell lines transformed by a human retrovirus. (1985) (14)
Multistep regulation of enhancer activity of the 21-base-pair element of human T-cell leukemia virus type I (1992) (13)
Circulating Interleukin-2 Receptors Are a Group of Multimeric Proteins with Immunoreactivity for Interleukin-2 Receptor α, β, and γ Chains (1996) (13)
Human Parvovirus (HPV/B19) Infection with Purpura (1989) (13)
Murine thymic nurse cell clone supports the growth of fetal thymocytes in the presence of interleukin 2 (1991) (12)
Macrophage–T Cell Interaction Is Essential for the Induction of p75 Interleukin 2 (IL–2) Receptor and IL–2 Responsiveness in Human CD4+ T Cells (1991) (12)
BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma (2020) (12)
Characterization of the γc chain among 27 unrelated Japanese patients with X-linked severe combined immunodeficiency (X-SCID) (2000) (12)
Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells. (2019) (11)
12‐O‐Tetradecanoylphorbol‐13‐acetate induces the enhancer function of human T‐cell leukemia virus type I (1987) (11)
Laboratory infection with human parvovirus B19. (1991) (11)
Adenosine 3′,5′‐cyclic monophosphate (cAMP) inhibits phorbol ester‐induced growth of an IL‐2‐dependent T cell line (1988) (11)
Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus (2000) (11)
[Prevalence of anti-human parvovirus antibody in pregnant women]. (1990) (11)
ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation* (2014) (10)
Cell type‐specific tyrosine phosphorylation of IL‐2 receptor β chain in response to IL‐2 (1992) (10)
CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma (2019) (10)
Regulation by Interleukin-2 ( IL-2 ) and Interferon y of IL-2 Receptor y Chain Gene Expression in Human Monocytes (2002) (10)
Selective growth advantage of wild-type lymphocytes in X-linked SCID recipients (2002) (10)
The IL-2/IL-2 receptor system: involvement of a novel receptor subunit, gamma chain, in growth signal transduction. (1992) (10)
MONOCLONAL ANTIBODY DEFINING A MOLECULE POSSIBLY IDENTICAL TO THE p 75 SUBUNIT OF INTERLEUKIN 2 RECEPTOR BY TOSHIKAZU TAKESHITA , YUSO GOTO , KOHTARO TADA (1989) (9)
A monoclonal antibody that defines p24, a core protein of adult T-cell leukemia virus, and its precursor. (1984) (9)
Production of plasminogen activators by human T-cell leukaemia virus-transformed human T cell lines. (1985) (9)
Implication of the common gamma chain of the IL-7 receptor in intrathymic development of pro-T cells. (1994) (9)
Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T‐cell leukemia‐derived cells (2017) (8)
An essential role of MASP-1 in activation of the lectin pathway (2000) (8)
Monoclonal antibodies defining distinct epitopes of the human IL-2 receptor beta chain and their differential effects on IL-2 responses. (1991) (8)
IL-2 receptor gamma chain expression on CD34 positive hematopoietic progenitor cells from bone marrow and cord blood. (1996) (8)
Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor .8 and y chains (8)
Interleukin‐2 receptor β and γ chain dysregulation during the inhibition of CD4 T cell activation by human immunodeficiency virus‐1 gp120 (1997) (8)
Inhibition of Tumor Growth and Metastasis by Depletion of Vesicular Sorting Protein Hrs: Its Regulatory Role on E-Cadherin and B-Catenin (2007) (8)
IL-2-dependent in vivo and in vitro tyrosine phosphorylation of IL-2 receptor gamma chain. (1992) (7)
Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells. (2006) (7)
CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells. (2020) (7)
Selective Inhibition of High‐ but Not Low‐Affinity Interleukin 2 Binding by Lectins and Anti‐Interleukin 2 Receptor α Antibody (1988) (7)
Immunological characterization of human decidual mononuclear cells: natural killer activity, response to interleukin-2 and distribution of interleukin-2 receptor subunits. (2010) (6)
T cell reconstitution by haploidentical BMT does not restore the diversification of the Ig heavy chain gene in patients with X-linked SCID. (1995) (6)
Tyrosine phosphorylation of an interleukin 2 receptor-like protein in cells transformed by human T cell leukemia virus type I (1987) (6)
Circulating interleukin-2 receptors are a group of multimeric proteins with immunoreactivity for interleukin-2 receptor alpha, beta, and gamma chains. (1996) (6)
The evidence for the IL-2 receptor β chain processing from p70 to p75 (1990) (6)
Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells. (2014) (6)
Gene Therapy Model of X-linked Severe Combined Immunodeficiency Using a Modified Foamy Virus Vector (2013) (5)
Two Decades of Adult T-Cell Leukemia and HTLV-I Research (2003) (5)
Complex formation of human T-cell leukemia virus type I p40tax transactivator with cellular polypeptides (1992) (5)
Regulation of CD3- lymphocyte function with an antibody against the IL-2 beta chain receptor: modulation of NK and LAK activity and production of IFN gamma. (1990) (5)
Induction of IL-1 beta-converting enzyme-independent apoptosis by IL-2 in human T cell lines. (1997) (5)
Pure red cell aplasia induced by B19 parvovirus during allogeneic bone marrow transplantation. (1989) (5)
Update: new CD antigens, 1996. (1997) (5)
Regulation of IL-2 signaling. (1997) (5)
A study by means of a new assay of the relationship between an outbreak of erythema infectiosum and non-immune hydrops fetalis caused by human parvovirus B19. (1995) (5)
Three novel mutations in the interleukin-2 receptor γ chain gene in four Japanese patients with X-linked severe combined immunodeficiency (1995) (5)
Establishment of multifunctional monoclonal antibody to the nonstructural protein, NS1, of human parvovirus B19. (2003) (5)
Lack of intermediate-affinity interleukin-2 receptor in mice leads to dependence on interleukin-2 receptor alpha, beta and gamma chain expression for T cell growth. (1996) (4)
Factors influencing the establishment of persistent infection of HVJ (Sendai virus)in L cells. (1974) (4)
A transgenic mouse model for non-immune hydrops fetalis induced by the NS 1 gene of human parvovirus B 19 (4)
Prolongation of allograft survival by administration of mAb specific for the three subunits of IL-2 receptor. (1998) (4)
BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma (2021) (4)
Demonstration of a cross-talk between IL-2 and IL-5 in phosphorylation of IL-2 and IL-5 receptor beta chains. (1996) (4)
[Structure and function of IL-2 receptor subunits]. (1994) (3)
Purification and Characterization of a T Lymphocyte‐Derived Differentiation‐Inducing Factor for Human Promyelocytic Cell Line (HL‐60) and Its Relationship to Lymphotoxin (1989) (3)
Immunity to protozoan parasite infection (PP-002) (2010) (3)
Critical Involvement of OX 40 Ligand Signals in the T Cell Priming Events During Experimental Autoimmune Encephalomyelitis 1 (2001) (2)
Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271. (2020) (2)
Induces Autoimmune-Like Diseases Constitutive OX 40 / OX 40 Ligand Interaction (2002) (2)
Tyrosine phosphorylation of interleukin 2 receptor-related proteins in phytohemagglutinin-activated human lymphocytes. (1987) (2)
Xenotransplantation elicits salient tumorigenicity of adult T‐cell leukemia‐derived cells via aberrant AKT activation (2016) (2)
Functional mapping of the activity of the R region in the human T-cell leukemia virus type I long terminal repeat to increase gene expression (1989) (2)
Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein. (2021) (2)
The interleukin 2 receptor (IL-2R): The IL-2R a subunit alters the function of the IL-2R f8 subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R a subunit (1)
Subtypes of hepatitis B antigen (HBAg) in Peru. (1974) (1)
[Intrauterine infection of parvo virus B19]. (2001) (1)
Human T‐Lymphoblastoid Cell Lines with High and Low Abilities to Produce Interferon‐Gamma Constitutively and Their Susceptibilities to Interferon (1987) (1)
[Diagnosis for human parvovirus B19-polyarthritis: usefulness of empty particle B19.ELISA and B19-DNA.PCR]. (1998) (1)
Multistep Regulation ofEnhancer Activity ofthe21-Base-Pair Element ofHumanT-Cell LeukemiaVirusTypeI (1992) (1)
This information is current as T Cells + Memory CD 4 on Generation of Effector and Central Differential Requirements for OX 40 Signals (2007) (1)
Lymphold reconstitution in X-linked severe combined immunodeficient mice by retrovirus-mediated gene transfer (2002) (1)
Abstract 5163: Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice (2009) (1)
Human retrovirus-induced IL-2 receptors and their possible role in transduction of continuous cell growth signal. (1984) (1)
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. (2015) (1)
Carbonic Anhydrase IX Promotes the Tumorigenicity of Adult T-Cell Leukemia/Lymphoma-Derived Cells in NOG Mice (2015) (1)
[Structural similarity and signal transduction of cytokine receptors]. (1992) (1)
Dysregulation of interleukin-2 receptor beta and interleukin-2 receptor gamma expression during HIV infection. (1998) (1)
RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer (2022) (1)
Signal Transduction by IL-2 Receptor β Chain: An Immunocytochemical Study. (1990) (1)
of human cells mouse: an excellent recipient mouse model for engraftment γ NOD/SCID/ (2012) (1)
Molecule by Human Th2 Cells In Vivo Selective Expression of a Novel Surface (1999) (0)
High affinity interleukin 2 receptors in HTLV-1-Infected T cells can mediate signals for gene expression (1987) (0)
Low CD274 expression increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma. Anti-CD274 staining of a clinical specimen from a patient with cholangiocarcinoma by surgical resection (2014) (0)
Lymp hold reconstitution in X-linked severe combined immunodeficient mice by retrovirus-mediated gene transfer (2006) (0)
OX40 signals preferentially mediate the generation of effector memory but not central memory CD4+ T cells (B15) (2007) (0)
Differential roles for OX40 and IL‐7 on homeostasis of effector memory CD4+ T cells (2008) (0)
Natural Killer Cells Activated by Interleukin 2 Treatment in Vivo Respond to Interleukin 2 Primarily through the p75 Receptor and Maintain the p55 (TAC) Negative Phenotype1 (2006) (0)
A process for preparing a mouse for receiving, differentiation and proliferation of diverse cell is suitable, and the mouse produced thereby their use (2001) (0)
■ Graduate Schools / Undergraduate Schools (2007) (0)
Abstract 660: Pravastatin Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension Associated Through Down-regulation of Stromal Cell-Derived Factor-1 in Mice (2007) (0)
CD271 regulates cell proliferation and motility in head and neck cancer. (2016) (0)
Detection of antibody for HTLV-I by Behring ELISA Processor II and clinical examination about HTLV-I carriers (1987) (0)
Signal transduction and its abnormalities. (1999) (0)
Physical association of JAK tyrosine kinases with the interleukin 2 receptor subunits (1994) (0)
, Angiogenesis in Peripheral Ischemia in Mice Important Role of Erythropoietin Receptor to Promote VEGF Expression and (2007) (0)
Inflammatory bowel diseases (PP-065) (2010) (0)
Constitutive OX40/OX40 Ligand Interaction (2002) (0)
Expression of the interleukin 2 receptor ? chain on trophoblast cells (1994) (0)
659. Application of HSVtk Suicide Gene to X- SCID Gene Therapy: Ganciclovir Treatment Selectively Elmiinates Gene Corrected Cells In Vitro and In Vivo (2006) (0)
Abstract 121: Inhibition of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice (2007) (0)
ESF–JSPS Frontier Science Conference for Young Researchers (2008) (0)
Graduate schools of medicine in Japan : The status and problems of researcher training (2008) (0)
CD 28-Mediated Costimulation with CD 28 and Play Distinct Roles in Grb 2 and Gads Exhibit Different Interactions (2006) (0)
Expression and Regulation of the IL-2β-Chain Receptor on CD3- Lymphocytes (1990) (0)
Complex Indispensable Subunit of the IL-21 Receptor-Chain Is an γ Cutting Edge : The Common (2001) (0)
S3-1 Antiandrogenic effects of dibutyl phthalate and its metabolite, monobutyl phthalate(III. Recent subjects in the risk evaluation of chemicals) (2002) (0)
Expression of IL-2 receptor subunits, α, β, and γ, on HTLV-I-transformed T cells (1992) (0)
The evidence for the IL-2 receptor beta chain processing from p70 to p75. (1990) (0)
肺高血圧症自然発症モデル動物及びその作製方法、並びに、肺高血圧症に対する医薬組成物及び治療方法 (2007) (0)
OX40 Signals Determine the Fate of Memory CD8+ T cells following Listeria monocytogenes Infection (2008) (0)
Abstract: P682 GENETIC DELETION OF OX40 LIGAND SUPPRESSES THE DEVELOPMENT OF ATHEROSCLEROSIS IN APOLIPOPROTEIN EDEFICIENT MICE (2009) (0)
Humanized mouse (PP-100) (2010) (0)
Pathway Activation of the Lectin Complement Serine Protease ( MASP )-1 Contributes to Mannose-Binding Lectin ( MBL )-Associated (2008) (0)
Brief Report In Vivo Competitive Studies between Normal and Common g Chain-Defective Bone Marrow Cells: Implications for Gene Therapy (2000) (0)
Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry (2022) (0)
21 Co-inhibitory Roles for Glucocorticoid-induced TNF Receptor (GITR) in CD1d-dependent Natural Killer T Cells (2007) (0)
receptor gamma chain gene expression in human monocytes Regulation by interleukin-2 (IL-2) and interferon gamma of IL-2 (2011) (0)
This information is current as via CRTH 2 Receptor Chronic Allergic Inflammation of the Skin Plays an Essential Role in 2 Prostaglandin (2006) (0)
The common .GAMMA. chain of multiple cytokine receptors: Its implication in T cell development. (1995) (0)
Table of Contents (1987) (0)
ESCRT-0 Protein Hrs Is Targeted to Endosomes Independent of STAM and the Complex Formation with STAM Promotes Its Endosomal Dissociation* (2014) (0)
Cytokines, Constitutive Secretion (2004) (0)
Spontaneous pulmonary hypertension in mice associated with OX40 ligand overexpression (B82) (2007) (0)
Cytokines and Immunodeficiencies (1998) (0)
T + Memory Commitment of Effector CD8 OX40 Costimulatory Signals Potentiate the (0)
Longevity Cell-T Cell Contact Contributes to CD 4 T OX 40-OX 40 Ligand Interaction through T (2006) (0)
Expansion Cells and Their Capacity for Secondary Memory T + Determine Formation of CD 8 Tract , CD 27 , 4-1 BB , and OX 40 Collectively During Viral Infection of the Respiratory and Jannie (2005) (0)
522 Establishment of indirect immunofluorescence staining (IF) for detecting antibody to human parvovirus B19 and the prevalence of it in pregnant women. (1989) (0)
[The expression of IL-2 receptor subunits on various leukemic cells]. (1992) (0)
Identification of TL-Om 1 , an ATL Cell Line , as a Reference Material for Human 1 T-Lymphotropic Virus 1 Quantitative PCR (2014) (0)
Natural Killer Cells Activated by Interleukin 2 Treatment in Vivo Respond to Interleukin 2 Primarily through the p 75 Receptor and Maintain the p 55 ( TAC ) Negative Phenotype 1 (2006) (0)
Human parvovirus B 19-induced cell cycle arrest and apoptosis (0)
Abstract 2331: CD271 defines a cancer-initiating cell population in hypopharyngeal cancer (2015) (0)
Regulatory T cell-like activity of Foxp3 1 adult T cell leukemia cells (2006) (0)
Glucocorticoid‐induced TNF receptor signals inhibit activation of CD1d‐dependent natural killer T cells (2008) (0)

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