Kazutoshi Takahashi
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Kazutoshi Takahashiphilosophy Degrees
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#3846
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Philosophy
Kazutoshi Takahashi's Degrees
- PhD Biological Sciences Kyoto University
- Doctorate Medicine Kyoto University
Why Is Kazutoshi Takahashi Influential?
(Suggest an Edit or Addition)Kazutoshi Takahashi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors (2006) (23456)
- Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors (2007) (16003)
- The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells (2003) (3297)
- Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts (2008) (2844)
- Suppression of induced pluripotent stem cell generation by the p53–p21 pathway (2009) (1304)
- Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells (2008) (1069)
- Induction of pluripotent stem cells from fibroblast cultures (2007) (1020)
- Variation in the safety of induced pluripotent stem cell lines (2009) (875)
- Hypoxia enhances the generation of induced pluripotent stem cells. (2009) (747)
- Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. (2013) (661)
- A decade of transcription factor-mediated reprogramming to pluripotency (2016) (598)
- Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells (2012) (504)
- Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage (2011) (489)
- Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. (2015) (366)
- Role of ERas in promoting tumour-like properties in mouse embryonic stem cells (2003) (360)
- Induced Pluripotent Stem Cells (2011) (343)
- Generation of retinal cells from mouse and human induced pluripotent stem cells (2009) (322)
- Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells (2010) (298)
- Fbx15 Is a Novel Target of Oct3/4 but Is Dispensable for Embryonic Stem Cell Self-Renewal and Mouse Development (2003) (281)
- Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells (2013) (272)
- Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy (2009) (248)
- Generation of mouse-induced pluripotent stem cells with plasmid vectors (2010) (241)
- Induced pluripotent stem cells in medicine and biology (2013) (241)
- The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. (2014) (202)
- Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential (2014) (200)
- Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells (2013) (195)
- [Induction of pluripotent stem cells from mouse fibroblast cultures]. (2006) (167)
- Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. (2019) (162)
- Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease (2011) (161)
- Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells (2009) (154)
- Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts (2009) (141)
- Induction and Enhancement of Cardiac Cell Differentiation from Mouse and Human Induced Pluripotent Stem Cells with Cyclosporin-A (2011) (135)
- Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts (2013) (118)
- Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells—Brief Report (2009) (118)
- Cell Therapy Using Human Induced Pluripotent Stem Cell‐Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice (2015) (118)
- Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm (2014) (116)
- Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. (2012) (112)
- Characterization of Dendritic Cells and Macrophages Generated by Directed Differentiation from Mouse Induced Pluripotent Stem Cells (2009) (106)
- Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway* (2005) (101)
- Present and future challenges of induced pluripotent stem cells (2015) (100)
- Human Induced Pluripotent Stem Cells on Autologous Feeders (2009) (99)
- A developmental framework for induced pluripotency (2015) (95)
- Induction of pluripotency by defined factors (2011) (95)
- Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes (2014) (83)
- Generation and characterization of human induced pluripotent stem cells. (2009) (67)
- Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery. (2012) (64)
- Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells (2016) (58)
- Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). (2005) (55)
- Cellular reprogramming – lowering gravity on Waddington's epigenetic landscape (2012) (54)
- Orderly hematopoietic development of induced pluripotent stem cells via Flk‐1+ hemoangiogenic progenitors (2009) (50)
- Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells (2018) (50)
- Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells. (2010) (49)
- Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells (2013) (44)
- Reversal of Hypopigmentation in Phenylketonuria Mice by Adenovirus-Mediated Gene Transfer (1999) (40)
- Identification of genes involved in tumor-like properties of embryonic stem cells. (2006) (35)
- Mutation and polymorphic marker analyses of 65K- and 67K-glutamate decarboxylase genes in two families with pyridoxine-dependent epilepsy (1998) (28)
- Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models (2016) (28)
- Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations. (2016) (27)
- The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells (2014) (24)
- Direct reprogramming 101 (2010) (22)
- Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells (2021) (21)
- Preparation of 1,8-di-O-alkylaloe-emodins and 15-amino-, 15-thiocyano-, and 15-selenocyanochrysophanol derivatives from aloe-emodin and studying their cytotoxic effects. (2008) (20)
- Crystal structure of Bifidobacterium Longum phosphoketolase; key enzyme for glucose metabolism in Bifidobacterium (2010) (20)
- ECAT11/L1td1 Is Enriched in ESCs and Rapidly Activated During iPSCGeneration, but It Is Dispensable for the Maintenance and Induction of Pluripotency (2011) (19)
- Relation between tRNase activity and the structure of colicin D according to X-ray crystallography. (2004) (19)
- MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. (2018) (18)
- ERas is Expressed in Primate Embryonic Stem Cells but not Related to Tumorigenesis (2009) (18)
- Interaction Analysis of FABP4 Inhibitors by X-ray Crystallography and Fragment Molecular Orbital Analysis. (2016) (18)
- Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. (2020) (16)
- Novel phenylketonuria mutation detected by analysis of ectopically transcribed phenylalanine hydroxylase mRNA from lymphoblast (1992) (15)
- Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes (2015) (14)
- Cellular reprogramming. (2014) (12)
- Chromatographic analysis of site-specific antibody-drug conjugates produced by AJICAP first-generation technology using a recombinant FcγIIIa receptor-ligand affinity column. (2021) (12)
- One-step construction of ferritin encapsulation drugs for cancer chemotherapy. (2021) (11)
- Self-Renewal and Mouse Development Dispensable for Embryonic Stem Cell Fbx 15 Is a Novel Target of Oct 3 / 4 but Is (2003) (10)
- Crystal Structure of Bifidobacterium Longum Phosphoketolase (2010) (10)
- The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency (2020) (9)
- Protein engineering for improving the thermostability of tryptophan oxidase and insights from structural analysis (2018) (9)
- Anti-A b Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer ’ s Disease (2011) (7)
- Chemical Site-Specific Conjugation Platform to Improve the Pharmacokinetics and Therapeutic Index of Antibody-Drug Conjugates. (2021) (7)
- Lipoate-acid Ligase A modification of Native Antibody: Synthesis and Conjugation Site Analysis. (2021) (6)
- Response to Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells” (2013) (6)
- Substrate recognition mechanism of tRNA-targeting ribonuclease, colicin D, and an insight into tRNA cleavage-mediated translation impairment (2020) (6)
- Transfer-messenger RNA and SmpB mediate bacteriostasis in Escherichia coli cells against tRNA cleavage. (2015) (6)
- Generation of high quality iPS cells (2007) (5)
- Mitochondrial tRNA cleavage by tRNA-targeting ribonuclease causes mitochondrial dysfunction observed in mitochondrial disease. (2014) (5)
- Faculty of 1000 evaluation for CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. (2018) (4)
- " Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells " ( 2007 ) , by Junying Yu (2017) (4)
- Faculty Opinions recommendation of Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. (2019) (3)
- Faculty Opinions recommendation of CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. (2018) (3)
- Improved Sendai viral system for reprogramming to naive pluripotency (2022) (3)
- Evidence for DNA Cleavage Caused Directly by a transfer RNA-Targeting Toxin (2013) (2)
- Purification, crystallization and preliminary X-ray analysis of the catalytic domain of the Escherichia coli tRNase colicin D. (2006) (2)
- Naohiro Egawa Cells Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem (2012) (2)
- Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics (2022) (2)
- Development of a rapid and simple glycine analysis method using a stable glycine oxidase mutant. (2019) (2)
- Generation of Retinal Progenitor Cells From Human Induced Pluripotent Stem Cells (2009) (2)
- Generation of disease-specific induced pluripotent stem cells from Alzheimer's disease patients (2010) (2)
- Faculty Opinions recommendation of Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity. (2016) (1)
- The Past, Present and Future of Induced Pluripotent Stem Cells (2011) (1)
- Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection (2022) (1)
- Generation of disease-specific induced pluripotent stem cells from sporadic Parkinson's disease patients (2011) (1)
- Cancellation of c-MYC Silencing in Human Induced Pluripotent Stem Cells Contributes to the Efficient in Vitro Production of Platelets with the Ability of Hemostasis In Vivo. (2009) (1)
- Faculty Opinions recommendation of An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition. (2018) (1)
- Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells (2022) (1)
- Title ECAT 11 / L 1 td 1 is enriched in ESCs and rapidly activated during iPSC generation , but it is dispensable for the maintenance and induction of pluripotency (2017) (1)
- "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells" (2007), by Junying Yu et al. [1] (2018) (0)
- Crystal Structure of FABP4 in complex with 3-(5-cyclopropyl-2,3-diphenyl-1H-indol-1-yl)propanoic acid (2016) (0)
- A Cell-ebration of Induced Pluripotency (2016) (0)
- Differentiation of induced pluripotent stem cells from ALS patients generates motor neurons (2010) (0)
- Faculty Opinions recommendation of Generation of human oogonia from induced pluripotent stem cells in vitro. (2018) (0)
- Faculty of 1000 evaluation for Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency. (2018) (0)
- Faculty Opinions recommendation of Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. (2019) (0)
- Induced Pluripotent Stem Cell Experiments by Kazutoshi Takahashi and Shinya Yamanaka in 2006 and 2007 (2018) (0)
- Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts " ( 2007 ) , by Masato (2019) (0)
- model for dissecting somatic mosaicism and drug discovery Induced pluripotent stem cells from CINCA syndrome patients as a (2013) (0)
- Faculty Opinions recommendation of Discovery and validation of human genomic safe harbor sites for gene and cell therapies. (2022) (0)
- A Cell-ebration of Induced Pluripotency. (2016) (0)
- "Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins" (2009), by Hongyan Zhou et al (2018) (0)
- " Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins " ( 2009 ) , by Hongyan Zhou (2018) (0)
- Embryonic stem cells express a transforming oncogene (2005) (0)
- "Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts" (2007), by Masato Nakagawa et al (2017) (0)
- The iPS Breakthrough Paper (2014) (0)
- Faculty Opinions recommendation of Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation. (2020) (0)
- Post-transcriptionally regulated genes are essential for pluripotent stem cell survival (2021) (0)
- Crystal Structure of FABP4 in complex with 3-[5-cyclopropyl-3-(3-methoxypyridin-4-yl)-2-phenyl-1H-indol-1-yl] propanoic acid (2016) (0)
- " Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts " ( 2007 ) (2018) (0)
- Faculty Opinions recommendation of yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. (2019) (0)
- Faculty Opinions recommendation of Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency. (2021) (0)
- Aoi Stomach Cells Generation of Pluripotent Stem Cells from Adult Mouse Liver and (2012) (0)
- Mouse Molecular Genetics Symposium : Upstream and downstream regulators of Nanog and ERas, two important molecules in ES cell biology (2004) (0)
- Faculty Opinions recommendation of Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. (2019) (0)
- Title Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice (2019) (0)
- "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells" (2007), by Junying Yu et al. (2022) (0)
- Faculty of 1000 evaluation for Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation. (2018) (0)
- Induced Pluripotent Stem Cell Experiments by Kazutoshi Takahashi and Shinya Yamanaka in 2006 and 2007 [ 1 ] (2019) (0)
- Faculty Opinions recommendation of Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming. (2020) (0)
- Faculty Opinions recommendation of Xist nucleates local protein gradients to propagate silencing across the X chromosome. (2021) (0)
- Faculty Opinions recommendation of Human naive epiblast cells possess unrestricted lineage potential. (2021) (0)
- Faculty Opinions recommendation of Mapping Gene Circuits Essential for Germ Layer Differentiation via Loss-of-Function Screens in Haploid Human Embryonic Stem Cells. (2020) (0)
- Derivation of Human Induced Pluripotent Stem Cells on Autologous Feeders (2011) (0)
- Faculty Opinions recommendation of A widespread alternate form of cap-dependent mRNA translation initiation. (2018) (0)
- Crystal Structure of FABP4 in complex with 3-{5-cyclopropyl-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-[3-(propan-2-yloxy) phenyl]-1H-indol-1-yl}propanoic acid (2016) (0)
- Cooperative Study Combining X-ray Crystal Structure Analysis and FMO Calculation: Interaction Analysis of FABP4 Inhibitors (2021) (0)
- Establishment of iPS cells from amyotrophic lateral sclerosis model mice and motor neuronal differentiation (2011) (0)
- [Simple test for the evaluation of the safety of human induced pluripotent stem cells]. (2010) (0)
- Neurodegenerative disease-specific induced pluripotent Stem cells research (2009) (0)
- "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells" (2007), by Junying Yu et al. [1] (2022) (0)
- Methode de reprogrammation nucleaire (2008) (0)
- Generation of disease-specific induced pluripotent stem cells from hereditary Parkinson’s disease (2010) (0)
- Faculty Opinions recommendation of Distinct molecular trajectories converge to induce naive pluripotency. (2019) (0)
- In-vivo Imaging of Neuronal Differentiation and Function of Intracranially Implanted Induced Pluripotent Stem Cells (iPSCs) Using A Designer Receptor Exclusively Activated by A Designer Drug (DREADD) (2014) (0)
- Generation of Retinal Progenitor Cells From Induced Pluripotent Stem (iPS) Cells (2008) (0)
- Faculty Opinions recommendation of Metabolic Control over mTOR-Dependent Diapause-like State. (2020) (0)
- A stress-reduced passaging technique improves the viability of human pluripotent cells (2021) (0)
- Induction of astrocyte differentiation from human induced pluripotent stem cells carrying mutant SOD1 (2011) (0)
- Ribonuclease from Escherichia coli complexed with its inhibitor protein (2005) (0)
- Establishment of iPS cells from amyotrophic lateral sclerosis model mice (2010) (0)
- Crystal Structure of FABP4 in complex with 3-(2-phenyl-1H-indol-1-yl)propanoic acid (2016) (0)
- Faculty Opinions recommendation of Mailing viable mouse freeze-dried spermatozoa on postcards. (2021) (0)
- 18 The Past , Present and Future of Induced Pluripotent Stem Cells (2012) (0)
- Faculty Opinions recommendation of Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs. (2020) (0)
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What Schools Are Affiliated With Kazutoshi Takahashi?
Kazutoshi Takahashi is affiliated with the following schools: