Kazuyuki Tobe

Q: What Schools Are Affiliated With Kazuyuki Tobe

Kazuyuki Tobe is affiliated with the following schools: Hokkaido University, University of Tokyo, Osaka University, University of Toyama, Kyoto University

Kazuyuki Tobe's AcademicInfluence.com Rankings

Kazuyuki Tobe

Computer Science

#8282

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#8707

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Computational Linguistics

#1812

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#1831

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Machine Learning

#3352

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#3392

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Artificial Intelligence

#3650

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#3702

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computer-science Degrees

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Computer Science

Kazuyuki Tobe's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

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Kazuyuki Tobe's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity (2001) (4863)
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2003) (3033)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. (2006) (2634)
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance (1999) (1243)
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions (2007) (1239)
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 (1994) (1071)
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. (1998) (985)
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. (2001) (962)
Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance* (2006) (867)
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. (2007) (776)
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. (2002) (714)
Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice (2009) (637)
The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance* (2001) (593)
A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. (1994) (560)
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. (2000) (532)
Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels (2007) (453)
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. (2012) (445)
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. (2005) (431)
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase (1999) (428)
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling (2002) (395)
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. (2011) (386)
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity* (2004) (384)
Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis* (1998) (380)
Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. (1995) (336)
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. (2007) (329)
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways* (2006) (322)
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. (1993) (313)
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone (1997) (307)
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice (1996) (286)
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. (2001) (284)
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. (2001) (282)
Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44 and p42(*) (1995) (266)
A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. (1998) (264)
The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes (2000) (264)
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. (2000) (264)
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. (2008) (259)
Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. (1994) (255)
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. (2002) (249)
Japanese Clinical Practice Guideline for Diabetes 2019 (2020) (243)
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes (2002) (242)
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. (2004) (240)
Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. (1995) (238)
Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling (2007) (225)
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. (2008) (216)
Molecular Mechanism of Insulin Resistance and Obesity (2003) (202)
Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation (2001) (198)
Growth Hormone and Prolactin Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrate-1, -2, and -3, Their Association with p85 Phosphatidylinositol 3-Kinase (PI3-kinase), and Concomitantly PI3-kinase Activation via JAK2 Kinase* (1998) (189)
Japanese Clinical Practice Guideline for Diabetes 2019 (2020) (188)
Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. (1999) (173)
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice (2013) (171)
Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study (2014) (169)
Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India (2013) (168)
SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. (2015) (160)
Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells. (1992) (158)
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. (2009) (154)
Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell. (1987) (152)
Genome-wide association study identifies three novel loci for type 2 diabetes. (2014) (149)
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors (2017) (148)
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. (2003) (145)
Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. (2012) (145)
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. (1997) (140)
Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts (2002) (139)
Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2−/−Mouse Liver* (2001) (138)
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes (2016) (136)
Cell Type–Specific Angiotensin II–Evoked Signal Transduction Pathways (1998) (134)
Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes. (1996) (126)
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ (2008) (125)
Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes. (1997) (124)
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. (2006) (121)
Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. (1989) (118)
Implications of altered NAD metabolism in metabolic disorders (2019) (114)
Constitutive Tyrosine Phosphorylation of ErbB-2 via Jak2 by Autocrine Secretion of Prolactin in Human Breast Cancer* (2000) (111)
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. (2000) (104)
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. (2012) (103)
Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice. (2011) (102)
Upstream Mechanisms of Glycogen Synthase Activation by Insulin and Insulin-like Growth Factor-I (1995) (101)
Role of Insulin Receptor Substrate-1 and pp60 in the Regulation of Insulin-induced Glucose Transport and GLUT4 Translocation in Primary Adipocytes* (1997) (100)
Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3 q , 15 q , and 20 q and Identifies Two New Candidate Loci on 7 p and 11 p (2002) (100)
Lack of Insulin Receptor Substrate‐2 Causes Progressive Neointima Formation in Response to Vessel Injury (2003) (96)
The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis (2018) (92)
Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals (2012) (88)
Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation. (1994) (88)
Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1 (*) (1995) (87)
Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. (1993) (85)
Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes. (1999) (85)
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. (1993) (84)
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. (2004) (81)
Serum levels of vascular endothelial growth factor in patients with acute myocardial infarction undergoing reperfusion therapy. (1997) (80)
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin‐induced mouse model of asthma (2013) (79)
HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance (2016) (78)
Signal transduction mechanism of insulin and insulin-like growth factor-1. (1996) (76)
Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials (2014) (74)
A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS (2017) (74)
Mitochondrial gene mutation and insulin-deficient type of diabetes mellitus (1993) (73)
Impact of divergent effects of astaxanthin on insulin signaling in L6 cells. (2013) (73)
Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes* (2013) (73)
Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese (2011) (69)
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca2+] elevation signals (2002) (66)
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. (2012) (66)
In vivo depletion of CD206+ M2 macrophages exaggerates lung injury in endotoxemic mice. (2015) (65)
Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression. (1998) (64)
Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway (2009) (64)
Hypoxia and hypoxia/reoxygenation activate Src family tyrosine kinases and p21ras in cultured rat cardiac myocytes. (1996) (63)
Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. (2005) (63)
Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. (1991) (63)
SH2-containing Inositol Phosphatase 2 Predominantly Regulates Akt2, and Not Akt1, Phosphorylation at the Plasma Membrane in Response to Insulin in 3T3-L1 Adipocytes* (2004) (62)
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. (1998) (62)
Both Insulin Signaling Defects in the Liver and Obesity Contribute to Insulin Resistance and Cause Diabetes in Irs2–/– Mice* (2004) (60)
Csk enhances insulin-stimulated dephosphorylation of focal adhesion proteins (1996) (60)
Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding. (1992) (60)
Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy. (2000) (60)
CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells (2019) (60)
Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes* (2014) (60)
Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function. (2000) (60)
Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection. (1992) (59)
Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway (2020) (59)
The role of PPAR? in high-fat diet-induced obesity and insulin resistance (2002) (58)
Expression of DGAT2 in White Adipose Tissue Is Regulated by Central Leptin Action* (2005) (57)
Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance (2012) (56)
Substrates for Insulin-Receptor Kinase (1990) (56)
Vascular endothelial growth factor (VEGF) activates Raf‐1, mitogen‐activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes (1998) (56)
Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo (2016) (55)
Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes. (2015) (54)
IRS‐2 branch of IGF‐1 receptor signaling is essential for appropriate timing of myelination (2008) (54)
Efficacy and tolerability of vildagliptin as an add-on to glimepiride in Japanese patients with Type 2 diabetes mellitus. (2010) (54)
Rimonabant Ameliorates Insulin Resistance via both Adiponectin-dependent and Adiponectin-independent Pathways* (2009) (53)
PACAP Attenuates NMDA-Induced Retinal Damage in Association with Modulation of the Microglia/Macrophage Status into an Acquired Deactivation Subtype (2013) (53)
Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. (1999) (50)
Replication Study for the Association of 9 East Asian GWAS-Derived Loci with Susceptibility to Type 2 Diabetes in a Japanese Population (2013) (48)
Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine. (1992) (47)
[Molecular mechanism of insulin resistance]. (2005) (47)
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals. (2002) (46)
The Radioprotective 105/MD-1 Complex Contributes to Diet-Induced Obesity and Adipose Tissue Inflammation (2012) (45)
Resistance to Neointimal Hyperplasia and Fatty Streak Formation in Mice With Adrenomedullin Overexpression (2002) (45)
Respiratory involvement in IgG4-related Mikulicz’s disease (2012) (44)
Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides. (2004) (44)
Insulin-induced tyrosine-phosphorylation in intact rat adipocytes. (1988) (43)
The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family. (1999) (42)
A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population (2012) (41)
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism (2019) (41)
CD11c+ M1-like macrophages (MΦs) but not CD206+ M2-like MΦ are involved in folliculogenesis in mice ovary (2018) (41)
Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-beta. (1988) (40)
Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial. (2022) (37)
Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population (2006) (37)
The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc. (1995) (37)
Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis (2019) (36)
Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity (2020) (36)
Utility of creatinine/cystatin C ratio as a predictive marker for adverse effects of chemotherapy in lung cancer: A retrospective study (2015) (36)
Insulin Resistance and Growth Retardation in Mice Lacking Insulin Receptor Substrate‐1 and Identification of Insulin Receptor Substrate‐2 (1996) (35)
Interstitial pneumonitis associated with infliximab therapy without methotrexate treatment (2009) (34)
Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin. (1993) (33)
Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population. (2013) (33)
Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population (2011) (33)
Pdx1 Expression in Irs2-deficient Mouse β-Cells Is Regulated in a Strain-dependent Manner* (2003) (32)
The role of PPARgamma in high-fat diet-induced obesity and insulin resistance. (2002) (31)
Immunological Detection of Phosphotyrosine-Containing Proteins in Rat Livers After Insulin Injection (1990) (30)
Phosphorylation state and biological function of a mutant human insulin receptor Val996. (1990) (30)
FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men (2016) (29)
Impact of Genetic Background and Ablation of Insulin Receptor Substrate (IRS)-3 on IRS-2 Knock-out Mice* (2003) (29)
Safety and efficacy of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice: interim results of the STELLA-LONG TERM post-marketing surveillance study (2018) (29)
A Mr = 190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the c-erbB-2 gene. (1987) (28)
Monoclonal Antibody Against Citrullinated Peptides Obtained From Rheumatoid Arthritis Patients Reacts With Numerous Citrullinated Microbial and Food Proteins (2015) (28)
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts. (1997) (28)
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age‐associated insulin resistance (2018) (28)
The role of PPARγ as a thrifty gene both in mice and humans (2000) (27)
Mesenchymal Stromal Cells in Bone Marrow Express Adiponectin and Are Efficiently Targeted by an Adiponectin Promoter-Driven Cre Transgene. (2019) (27)
Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases. (1992) (26)
Nuclear factor‐[kappa]B decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture‐induced sepsis * (2009) (26)
Secretory units of islets in transplantation index is a useful predictor of insulin requirement in Japanese type 2 diabetic patients (2013) (25)
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation (2018) (24)
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits (2012) (23)
Outcome and Prognostic Factors in Patients with Small Cell Lung Cancer who Receive Third-line Chemotherapy (2014) (22)
Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice. (2001) (22)
Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice (2011) (21)
Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance (2018) (21)
Antibody-mediated insulin resistance treated by cessation of insulin administration. (2000) (20)
Protein kinase cascade activated by mechanical stress in cardiocytes: possible involvement of angiotensin II. (1995) (20)
Mutant of Insulin Receptor Substrate-1 Incapable of Activating Phosphatidylinositol 3-Kinase Did Not Mediate Insulin-stimulated Maturation of Xenopus laevis Oocytes* (1996) (20)
NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter (2020) (20)
A rare case of adrenocorticotropic hormone (ACTH)-independent macroadrenal hyperplasia showing ectopic production of ACTH. (2012) (20)
Elevated levels of plasma lactate dehydrogenase is an unfavorable prognostic factor in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer, receiving treatment with gefitinib or erlotinib. (2016) (19)
Baseline characteristics and interim (3-month) efficacy and safety data from STELLA-LONG TERM, a long-term post-marketing surveillance study of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice (2016) (19)
Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer’s Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice (2020) (19)
Inhibition of tumor progression locus 2 protein kinase suppresses receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis through down-regulation of the c-Fos and nuclear factor of activated T cells c1 genes. (2010) (19)
CD206+ M2-Like Macrophages Are Essential for Successful Implantation (2020) (19)
Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. (2020) (19)
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers (2019) (19)
Peripheral PD1-positive CD4 T-Lymphocyte Count Can Predict Progression-free Survival in Patients With Non-small Cell Lung Cancer Receiving Immune Checkpoint Inhibitor (2019) (18)
Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan (2021) (18)
SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients (2017) (18)
M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue (2019) (18)
Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-{alpha} from 3T3-L1 preadipocytes. (2009) (17)
Differential effects of DNA tumor virus nuclear oncogene products on adipocyte differentiation (1987) (17)
Deforming arthropathy in a patient with IgG4‐related systemic disease: Comment on the article by Stone et al (2011) (17)
Successful desensitization by glargine administration in a patient with insulin allergy: a case report. (2009) (17)
Proteomic analysis of serum biomarkers for prediabetes using the Long‐Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus (2017) (16)
M2 macrophages in metabolism (2016) (16)
Elevated serum procalcitonin in anaphylaxis. (2013) (16)
Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: a subgroup analysis of the STELLA-LONG TERM study (3-month interim results). (2019) (16)
Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study (2019) (16)
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits (2012) (16)
[Pioglitazone and the risk of bladder cancer]. (2016) (16)
Miliary brain metastasis presenting with calcification in a patient with lung cancer: a case report (2012) (16)
Association of serum adiponectin with asthma and pulmonary function in the Japanese population. (2015) (16)
Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3‐kinase signalling (2003) (15)
Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines (2013) (15)
Role of protein kinase system in the signal transduction of stretch-mediated protooncogene expression and hypertrophy of cardiac myocytes (1993) (15)
Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes (2015) (14)
Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants (2021) (14)
Tyrosine phosphorylation of pp185 by insulin receptor kinase in a cell-free system. (1989) (14)
Adiponectin-Dependent and -Independent Pathways in Insulin-Sensitizing and Antidiabetic Actions of Thiazolidinediones (2006) (14)
A novel Y231del mutation of HFE in hereditary haemochromatosis provides in vivo evidence that the Huh‐7 is a human haemochromatotic cell line (2011) (14)
Concanavalin A-induced receptor aggregation stimulates the tyrosine kinase activity of the insulin receptor in intact cells. (1990) (14)
Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib. (2015) (13)
Primary pulmonary lymphoma presenting with multiple lung nodules. (2014) (13)
Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans. (1990) (13)
Visceral adipose tissue level, as estimated by the bioimpedance analysis method, is associated with impaired lung function (2011) (13)
Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies (2016) (13)
CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model (2021) (13)
Lactate Dehydrogenase and Body Mass Index are Prognostic Factors in Patients with Recurrent Small Cell Lung Cancer Receiving Amrubicin (2016) (12)
Presenting manifestations of hemophagocytic syndrome in a male patient with systemic lupus erythematosus (2009) (12)
Activation of MAP kinase and enhanced phosphorylation of the 350-kDa protein by mitogenic stimuli in quiescent Balb/c 3T3 cells. (1991) (12)
corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2004) (12)
A novel model of insulin‐dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIα (Thr286Asp) in pancreatic β‐cells (2008) (12)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population (2012) (11)
Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice. (2009) (11)
Aging attenuates the association of central obesity with the accumulation of metabolic risk factors when assessed using the waist circumference measured at the umbilical level (the Japanese standard method) (2013) (11)
Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice (2018) (11)
Purification of enzymatically inactive peptidylarginine deiminase type 6 from mouse ovary that reveals hexameric structure different from other dimeric isoforms (2011) (11)
Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer (2012) (11)
Severe autoimmune hemolytic anemia associated with IgM warm auto‐antibodies in primary Sjögren’s syndrome (2010) (11)
Clinical Parameters for Predicting the Survival in Patients with Squamous and Non-squamous-cell NSCLC Receiving PD-1 Inhibitor Therapy (2018) (10)
SRT1720, a SIRT1 Activator, Aggravates Bleomycin-Induced Lung Injury in Mice (2012) (10)
The role of PPARgamma as a thrifty gene both in mice and humans. (2000) (10)
Reconsideration of insulin signals induced by improved laboratory animal diets, Japanese and American diets, in IRS-2 deficient mice. (2009) (10)
Urinary afamin levels are associated with the progression of diabetic nephropathy. (2019) (10)
Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2. (2006) (10)
Sodium–glucose cotransporter 2 inhibitor, tofogliflozin, shows better improvements of blood glucose and insulin secretion in patients with high insulin levels at baseline (2017) (10)
Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia (2016) (9)
Autoantibodies to the insulin receptor (B-10) can stimulate tyrosine phosphorylation of the beta-subunit of the insulin receptor and a 185,000 molecular weight protein in rat hepatoma cells. (1989) (9)
Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice. (2018) (9)
Pseudo-Behçet’s disease associated with tuberculosis: a case report and review of the literature (2014) (9)
The role of PPARg in high-fat diet-induced obesity and insulin resistance (2002) (9)
Simultaneously developed polymyositis and autoimmune hepatitis (2011) (9)
Overexpression of MCP-1 in adipose tissues causes macrophage recruitment and insulin resistance (2006) (8)
Binding properties and proliferative potency of insulin-like growth factor I in fetal mouse liver cells. (1987) (8)
Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney. (2008) (8)
Real-World Evidence for Long-Term Safety and Effectiveness of Ipragliflozin in Japanese Patients with Type 2 Diabetes Mellitus: final Results of a 3-Year Post-Marketing Surveillance Study (STELLA-LONG TERM) (2020) (8)
Thymoma with Autoimmune Hemolytic Anemia (2014) (8)
IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. (2011) (8)
Safety and efficacy of ipragliflozin in elderly versus non-elderly Japanese patients with type 2 diabetes mellitus: a subgroup analysis of the STELLA-LONG TERM study (2018) (8)
Insulin Resistance Syndrome in Mice Deficient in Insulin Receptor Substrate‐1 (1997) (8)
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice. (2009) (8)
Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase ( p 125 FAK ) in Cultured Rat Cardiac Myocytes (1999) (7)
Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients with Type 2 Diabetes with Preserved Ejection Fraction (2021) (7)
Clinical manifestations of a sporadic maturity-onset diabetes of the young (MODY) 5 with a whole deletion of HNF1B based on 17q12 microdeletion. (2019) (7)
[Two cases of pulmonary sarcomatoid carcinoma mimicking malignant mesothelioma]. (2010) (7)
Usefulness of the Palliative Prognostic Index in patients with lung cancer (2014) (7)
Maturity-onset Diabetes of the Young Resulting from a Novel Mutation in the HNF-4α Gene (2002) (7)
[Pathogenesis of metabolic syndrome]. (2006) (7)
Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy. (2016) (7)
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis (DOI:10.1016/j.cmet.2006.02.010) (2006) (7)
Stimulation of the phosphorylation of cytoskeletal 350-kDa and 300-kDa proteins by insulin-like growth factor-I, platelet-derived growth factor and phorbol ester in rat 3Y1 cells. (1988) (7)
Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population (2013) (6)
Isoliquiritigenin attenuates adipose tissue inflammation and metabolic syndrome by modifying gut bacteria composition in mice. (2022) (6)
[A case of bronchiolitis with IgG4-positive plasma cells infiltration associated with Mikulicz's disease and autoimmune pancreatitis]. (2009) (6)
Genome-Wide Association Studies Identify Two Novel Loci Conferring Susceptibility to Diabetic Retinopathy in Japanese Patients with Type 2 Diabetes. (2021) (6)
Appetite Loss as an Adverse Effect During Treatment with EGFR-TKIs in Elderly Patients with Non-small Cell Lung Cancer. (2016) (6)
Reversible posterior leukoencephalopathy syndrome in a patient with systemic sclerosis. (2011) (6)
Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan (2020) (6)
Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue (2021) (6)
[The role of inflammation in the development of insulin resistance in type 2 diabetes]. (2011) (6)
Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects (2022) (6)
Inhibition of tumor progression locus 2 protein kinase decreases lipopolysaccharide-induced tumor necrosis factor alpha production due to the inhibition of the tip-associated protein induction in RAW264.7 cells. (2010) (5)
Anti-obesity effect of a hop-derived prenylflavonoid isoxanthohumol in a high-fat diet-induced obese mouse model (2020) (5)
Safety and effectiveness of ipragliflozin in elderly versus non-elderly Japanese type 2 diabetes mellitus patients: 12 month interim results of the STELLA-LONG TERM study (2019) (5)
New categorization of human vascular endothelial cells by pro- vs anti-proliferative phenotypes (2015) (5)
Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways (2016) (5)
Serum interleukin-5 levels correlate with disease activity of Churg–Strauss syndrome in a patient treated with a leucotriene receptor antagonist, pranlukast, and inhaled corticosteroid (2010) (5)
Association of Tumor PD-L1 Expression with the T790M Mutation and Progression-Free Survival in Patients with EGFR-Mutant Non-Small Cell Lung Cancer Receiving EGFR-TKI Therapy (2020) (5)
Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet (2021) (5)
Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance (2021) (4)
Systemic dissemination of chronic necrotizing pulmonary aspergillosis in an elderly woman without comorbidity: a case report (2012) (4)
Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable. (2007) (4)
Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions (2021) (4)
Physiologic Target, Molecular Evolution, and Pathogenic Functions of a Monoclonal Anti–Citrullinated Protein Antibody Obtained From a Patient With Rheumatoid Arthritis (2020) (4)
Bofutsushosan Improves Gut Barrier Function with a Bloom of Akkermansia Muciniphila and Improves Glucose Metabolism in Diet-Induced Obese Mice (2018) (4)
Anti-TIF1γ antibody-positive dermatomyositis in a 15-year-old boy with Epstein-Barr virus-related nasopharyngeal cancer receiving nivolumab. (2020) (4)
Comment on: arthropathy with infiltrate IgG4-positive plasma cells in synovium. (2012) (4)
Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice (2008) (4)
Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice (2018) (4)
35th Annual Meeting of the European Association for the Study of Diabetes (2016) (3)
Evaluation of Sanazole Cytotoxicity in Human Drug-Sensitive and MDR Uterine Sarcoma Cells (2013) (3)
Safety and effectiveness of ipragliflozin in Japanese patients with type 2 diabetes mellitus and impaired renal function: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM) (2020) (3)
Ornithine decarboxylase induction during liver regeneration in IRS-1-deficient mice. (1995) (3)
[The role of PPARgamma in the onset of type 2 diabetes]. (2003) (3)
Anti‐programmed death ligand 1 therapy‐induced type 1 diabetes presenting with multiple islet‐related autoantibodies (2019) (3)
Glimepiride-Induced Bronchial Asthma (2008) (3)
Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects (2001) (3)
A Case of Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis Overlap Syndrome (2021) (3)
Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study (2015) (3)
An Efficient reproductive method for Irs2-/- mice with C57BL/6JJcl genetic background. (2008) (3)
Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients (2019) (3)
Case Series of Pleomorphic Carcinoma of the Lung Treated With Immune Checkpoint Inhibitors (2021) (3)
Hypertrophic Pachymeningitis in an Individual with Microscopic Polyangiitis (2013) (2)
Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy. (2016) (2)
Autoantibodies reactive to PEP08 are clinically related with morbidity and severity of interstitial lung disease in connective tissue diseases (2018) (2)
Systemic Sarcoidosis with Subcutaneous Lesions in an 85‐Year‐Old Female (2013) (2)
Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice (2015) (2)
Type 1 diabetes woman with repeated miscarriages successfully gave birth after introducing an insulin pump with a predictive low glucose suspend feature (2021) (2)
Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice (2019) (2)
Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and Sjögren's syndrome. (2015) (2)
TCR function analysis using a novel system reveals the multiple unconventional tumor‐reactive T cells in human breast cancer‐infiltrating lymphocytes (2020) (2)
Tumoral calcinosis in systemic sclerosis. (2013) (2)
Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene. (2002) (2)
Cytophagic histiocytic panniculitis in a 74-year-old man. (2013) (2)
The PREDICTIVETM Study: a multinational, prospective observational study to evaluate the safety and efficacy of insulin detemir treatment in patients with type 1 and 2 diabetes—data from the Japan cohort (2012) (2)
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration (2022) (2)
Angiotensin II enhances the increa se in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-a from 3 T 3L 1 preadipocytes (2009) (2)
Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces (2020) (2)
Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125) in Cultured Rat Cardiac Myocytes (1999) (1)
Distinct Phenotypes of Islet Antigen-specific CD4+ T Cells among the Three Subtypes of Type 1 Diabetes. (2020) (1)
[Insulin resistance in central nerve system]. (2006) (1)
Fulminant type 1 diabetes patients display high frequencies of IGRP-specific type 1 CD8+ T cells. (2021) (1)
Physiological target, molecular evolution and pathogenic functions of a monoclonal ACPA obtained from an RA patient. (2020) (1)
[Roles of chronic inflammation as a pathogenesis of insulin resistance]. (2012) (1)
Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125 FAK ) in Cultured Rat Cardiac Myocytes (1999) (1)
In Vivo Depletion of CD 206 + M 2 Macrophages Exaggerates Lung Injury in Endotoxemic Mice via Increased AP-1 Activation (2013) (1)
[Gene targeting approaches for diabetes research]. (2005) (1)
Immune Checkpoint Inhibitor for Non-small Cell Lung Cancer With Negative or Low Tumor PD-L1 Expression. (2021) (1)
Fragmented QRS on electrocardiography as a predictor for diastolic cardiac dysfunction in type 2 diabetes (2022) (1)
Molecular Pathogenesis of Type 2 Diabetes Mellitus and Obesity in Knockout Mice Models (2000) (1)
SRT 1720 , a SIRT 1 Activator , Aggravates Bleomycin-Induced Lung Injury in Mice (2013) (1)
A history of ischemic heart disease is a common cause of wheezing in the elderly of a Japanese local community. (2011) (1)
[Synchronous pulmonary hamartoma and lung cancer in a young patient]. (2011) (1)
Real-world evidence for long-term safety and effectiveness of ipragliflozin in treatment-naïve versus non-naïve Japanese patients with type 2 diabetes mellitus: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM) (2021) (1)
Association of Tumor PD-L1 Expression With Time on Treatment Using EGFR-TKIs in Patients With EGFR-Mutant Non-small Cell Lung Cancer. (2022) (1)
Adipose tissue-resident macrophages and obesity (2017) (1)
[The role of phosphorylation cascade in insulin action]. (1994) (1)
Internal Medicine (1) (2007) (1)
[IRS-1 knockout mouse]. (1998) (1)
Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM). (2021) (1)
A case of simultaneously developed sweet's syndrome and systemic lupus erythematosus in a man (2013) (1)
[A Retrospective Study Analyzing the Clinical Course of Patients with Non-Small Cell Lung Cancer Receiving Local or Systemic Therapy after Post-Operative Recurrence]. (2017) (1)
Pathogen-induced systemic plant signal triggers DNA rearrangements (2003) (1)
Pulmonary Involvement Of IgG4-positive Multi-organ Lymphoproliferative Syndrome (IgG4+ MOLPS) (2010) (1)
Clinical Course After Initiation of Nivolumab Therapy in Patients with EGFR-Mutated Non-Small Cell Lung Cancer With or Without Pd-L1 Expression (2017) (1)
O-46: Insulin signalling and insulin actions in the muscle, adipose tissue and liver of insulin resistant IRS-1 deficient mice (2009) (1)
Akt1 in Osteoblasts and Osteoclasts Controls Bone (2007) (1)
Accidental cannulation of a femoral central venous catheter into the iliolumbar vein: incidental detection by bone scintigraphy. (2015) (1)
Replication study of the association of rs7578597 in THADA, rs10886471 in GRK5, and rs7403531 in RASGRP1 with susceptibility to type 2 diabetes among a Japanese population (2015) (1)
A Case of Pulmonary Infarction Resembling Pneumonia during Immunosuppressive Treatment for Rheumatoid Arthritis (2021) (0)
Signal Insulin Transduction-Like Growth Mechanism Factor-1 of Insulin and (2006) (0)
IMMUNOPATHOLOGY AND INFECTIOUS DISEASES In Vivo Depletion of CD206 D M2 Macrophages Exaggerates Lung Injury in Endotoxemic Mice (2015) (0)
Correction to: Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study (2021) (0)
[Genetic factors and life styles related to diabetes mellitus--with special reference to multiple factor inheritance]. (2000) (0)
Pulmonary reversed halo sign as a presenting manifestation of rheumatoid arthritis. (2015) (0)
Portomesenteric venous gas and pneumatosis cystoides intestinalis in systemic sclerosis. (2013) (0)
OE-316 Kruppel-like family of transcription factor 5 is required for adipocyte differentiation(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English)) (2004) (0)
[Insulin action and its regulatory mechanisms]. (2011) (0)
Associations of immune checkpoint inhibitor therapy efficacy with clinical parameters and tumor‑infiltrating CD68‑positive cell counts in patients with EGFR‑mutant non‑small cell lung cancer (2023) (0)
Impact of Immune Checkpoint Inhibitor Therapy on The Overall Survival in Elderly Patients With Non-Small Cell Lung Cancer (2020) (0)
[Defects in insulin's signalling process and diabetes mellitus]. (1997) (0)
Respiratory Involvement In IgG4-Related Disease (2011) (0)
1987-P: Nampt Deletion Changes Metabolism in Adipose Tissue and Prevents Diet-Induced Obesity (2019) (0)
[A Case of Lung Adenocarcinoma Presenting with Leptomeningeal Carcinomatosis Successfully Treated with Afatinib after Erlotinib-Induced Hepatotoxicity]. (2017) (0)
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation (2018) (0)
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism (2019) (0)
Endobronchial Ultrasonography With Guide Sheath (EBUS-GS) Combined With Virtual Bronchoscopic Navigation (VBN) Increases Histological Diagnostic Yield In Peripheral Pulmonary Lesions (2012) (0)
Anti-IRS-1 monoclonal antibody, 6G5, cross-reacts to IRS-2. (1996) (0)
PACAP Attenuates NMDA-Induced Retinal Damage in Association with Modulation of the Microglia/Macrophage Status into an Acquired Deactivation Subtype (2013) (0)
Impact of sequential therapy with osimertinib on the overall survival in patients with EGFR-mutant non-small cell lung cancer (2021) (0)
Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM (2021) (0)
Correction to: Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM (2021) (0)
Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice (2018) (0)
Efficacy of immune checkpoint inhibitor therapy in patients with pulmonary sarcomatoid carcinoma in clinical practice. (2023) (0)
Use of a Phase-Oriented Management System Against an Outbreak of Infectious Gastroenteritis in an Evacuation Center After the Great East Japan Earthquake (2013) (0)
0863 ANALYSIS OF FOCAL ADHESION RELATED TYROSINE KINASE IN CARDIAC MYOCYTE STIMULATED BY VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) (1997) (0)
Depletion of CD2M2-Like Macrophages Promotes the Browning of the White Adipose Tissue (2018) (0)
Tu-W22:1 Role of adipokines in obesity-linked insulin resistance, metabolic syndrome and atherosclerosis (2006) (0)
Glycolytic Flow in Mature Erythrocytes Hemolytic Anemia by Altering the Adenylyltransferase 3 ( Nmnat 3 ) Causes Deficiency of Nicotinamide Mononucleotide Metabolism (2014) (0)
PE-411 KLF5 Controls Metabolic Stress Response in Metabolic Syndrome and Cardiovascular Disease(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society) (2007) (0)
[History of research on diabetes mellitus]. (2002) (0)
Tu-W22:3 Adiponectin modulates transcription factor activation by angiotensin II in smooth muscle cells (2006) (0)
Role of the liver in glucose homeostasis in PI 3-kinase p85 (cid:1) -deﬁcient mice (2009) (0)
Lack of Insulin Receptor Substrate-2 Is a Link between Insulin Resistance and an Increased Intima of the Vessel in Mice (2003) (0)
The Mechanism of Insul Mediated by the Insulin in-induced Signal Transduct Receptor Substrate Family ion (2006) (0)
A New Method for Albuminuria Measurement Using a Specific Reaction between Albumin and the Luciferin of the Firefly Squid Watasenia scintillans (2022) (0)
Identification of antigens of monoclonal autoantibody from rheumatoid arthritis patient, CCP-Ab1 under native condition and hypothesis of CCP-Ab1 induction mechanism (2017) (0)
Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice (2018) (0)
Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice (2022) (0)
NAD-Mediated Metabolic Reprogramming Epigenetically Regulates Gene Expression to Promote Preadipocyte Differentiation (2018) (0)
A Case of a Type 2 Diabetic Patient with Pyogenic Liver Abscess and Metastatic Muscle Abscesses of the Lower Limb Caused by Klebsiella pneumoniae (2008) (0)
Running title : Cell interactions in adipogenesis (2007) (0)
The gut microbiome: a core regulator of metabolism (2022) (0)
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors (2017) (0)
[Postprandial hyperglycemia]. (2006) (0)
Serum Levels of Soluble LR11 Are Associated with Insulin Resistance in the Patients with Type 2 Diabetes Mellitus (2018) (0)
Corrigendum to “Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan” (2021) (0)
Translocation of IRS-1 to Cytosol Attenuates Insulin-Stimulated Glucose Transport without Affecting PI3-Kinase Activity (2010) (0)
Correction to: Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM (2021) (0)
Implications of altered NAD metabolism in metabolic disorders (2019) (0)
Vascular Intima Formation in Insulin Receptor Substrate-2 Deficient Mice (2002) (0)
A Case of Granulomatosis with Polyangiitis with Various Breast Lesions as the Initial Symptoms: A Case-Based Review (2021) (0)
[Glucose metabolism in adipose tissue]. (2002) (0)
[Targets in the treatment of diabetes mellitus]. (1991) (0)
P3‐7: Mepolizumab may not induct long term remission in patients with eosinophilic granulomatosis with polyangiitis with high relapse rates (2021) (0)
KRÜPPEL-LIKE FACTOR 5 IS A KEY TRANSCRIPTION FACTOR OF ADIPOCYTE DIFFERENTIATION (2004) (0)
, R receptor substrate 1-deficient mice . muscles and livers of insulin-resistant , insulin Insulin signalling and insulin actions in the (1996) (0)
The Association Between the Serum KL-6 Level and the Risk of Radiation Pneumonitis (2018) (0)
Relationship between Patient Characteristics and the Timing of Provision of Explanation about DNAR to Patients with Advanced Lung Cancer (2020) (0)
Quantitative Analysis Of CD64 Expression On Neutrophils For Distinguishing Between Infections And Inflammatory Diseases In Hospitalized Patients With Lung Infiltration (2012) (0)
Macrophages React to Postprandial Signals and Regulate the Response to Feeding through Akt-mTOR–Dependent Production of IL-10 (2018) (0)
Abstract 394: Posttranslational Modification Of Klf5 Mediates Metabolic Dysfunction And Vascular Disease In Metabolic Syndrome (2007) (0)
[Metabolic syndrome]. (2010) (0)
PDGF receptor signal mediates the contribution of Nestin-positive cell lineage to subcutaneous fat development. (2023) (0)
Tu-P7:53 KLF5 is involved in both metabolic regulation and atherosclerotic lesion formation (2006) (0)
Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice (2023) (0)
The Mechanism of the Action of Thiazolidine Derivatives (1999) (0)
[Efficacy and toxicity of pemetrexed monotherapy for previously untreated elderly patients with non-squamous cell lung cancer with wild-type(or unknown)EGFR status]. (2014) (0)
[Goal of treatment for diabetic patients]. (2012) (0)
Impact of Immune Checkpoint Inhibitor on the Survival in Elderly Patients with Non-Small Cell Lung Cancer (2020) (0)
Widespread Mechanic’s Hands in Antisynthetase Syndrome With Anti-OJ Antibody (2021) (0)
YI-838 KLF5 PLAYS A PIVOTAL ROLE IN METABOLIC REGULATION AND ATHEROSCLEROSIS (2007) (0)
PUB005 CT Findings Reduce the Risk of EBUS-TBNA (2017) (0)
Failure of compensatory beta-cell hyperplasia in response to insulin resistance plays a crucial role in the development of type 2 diabetes (2000) (0)
Perioperative C‐peptide index is associated with the status of diabetes management after pancreatectomy (2022) (0)
Role of the insulin receptor kinase activity in insulin action. (1988) (0)
Front Cover: Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice (2022) (0)
A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS (2017) (0)
Sirt1 Activator SRT1720 Promotes Tumor Cell Migration And Lung Metastasis In Mouse Models Of Breast Cancer (2010) (0)
N-glycan in the monoclonal ACPA, CCP-Ab1 the variable region promotes the exacerbation of experimental arthritis. (2023) (0)
188-OR: Partial Depletion of CD206 M2-Like Macrophages Enhances Preadipocyte Differentiation via Reduction of Wnt Signaling (2019) (0)
A case of wild-type transthyretin cardiac amyloidosis with rheumatoid arthritis (2020) (0)
A Case of Combined-histology Lung Carcinoma (Adenocarcinoma Plus Small Cell Carcinoma) Presenting with Changes in the Tumor Marker Profile and Histological Findings During the Clinical Course (2018) (0)
The Role of NAD Metabolism in Adipocyte Differentiation (2016) (0)
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers (2019) (0)
Sirt1 Activator SRT1720 Suppresses Inflammatory Reaction In OVA-induced Asthma Model Mouse (2010) (0)
KLF5 is important for both metabolic regulation and atherosclerotic lesion formation (2006) (0)
Molecular analysis of Cardiac Hypertrophy by Mechanical Stress:Involvement of Stretch-Induced Protein Kinase Cascade (1993) (0)
Page kidney in a patient with granulomatosis with polyangiitis (Wegener's) (2012) (0)
Relationshipoftheurinecortisollevelwiththeperformancestatus of patients with lung cancer: a retrospective study (2015) (0)
Abstract 5276: Sumoylation Of Klf5 Is A Molecular Switch Regulating Ppar-{delta}-containing Transcriptional Programs Of Lipid Metabolism (2008) (0)

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