Keiji Wada

Keiji Wada's AcademicInfluence.com Rankings

Keiji Wada

Biology

#13087

World Rank

#16613

Historical Rank

Neuroscience

#2247

World Rank

#2308

Historical Rank

biology Degrees

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Biology

Keiji Wada's Degrees

PhD Neuroscience University of Tokyo
Doctorate Medicine University of Tokyo

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Keiji Wada's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. (1997) (1696)
Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat (1989) (1057)
Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice (1999) (518)
Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain. (1992) (515)
Stargazin modulates AMPA receptor gating and trafficking by distinct domains (2005) (480)
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice (1998) (421)
Glutamate Transporter GLAST Is Expressed in the Radial Glia–Astrocyte Lineage of Developing Mouse Spinal Cord (1997) (398)
Microglia–Müller Glia Cell Interactions Control Neurotrophic Factor Production during Light-Induced Retinal Degeneration (2002) (368)
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. (2003) (366)
Functional Comparison of d‐Serine and Glycine in Rodents: The Effect on Cloned NMDA Receptors and the Extracellular Concentration (1995) (332)
Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor. (1988) (319)
Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity (1997) (291)
Primary structure and expression of β2: A novel subunit of neuronal nicotinic acetylcholine receptors (1988) (276)
The functions of UCH-L1 and its relation to neurodegenerative diseases (2007) (255)
Functions of the two glutamate transporters GLAST and GLT-1 in the retina. (1998) (250)
Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring (2010) (235)
Neurotoxins Distinguish Between Different Neuronal Nicotinic Acetylcholine Receptor Subunit Combinations (1990) (230)
Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome* (2006) (216)
Modification of Glial–Neuronal Cell Interactions Prevents Photoreceptor Apoptosis during Light-Induced Retinal Degeneration (2000) (214)
Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy* (2008) (201)
Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA (2005) (182)
Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein (1989) (172)
Diet‐induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring (2009) (159)
EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. (1996) (156)
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease (2014) (153)
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants. (2003) (152)
Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level (2015) (151)
Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas. (1997) (140)
Autoantigen Ro52 is an E3 ubiquitin ligase. (2006) (135)
Discovery of a novel type of autophagy targeting RNA (2013) (131)
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis (2008) (128)
Neuroprotective role of bradykinin because of the attenuation of pro‐inflammatory cytokine release from activated microglia (2007) (124)
Bradykinin-Induced Microglial Migration Mediated by B1-Bradykinin Receptors Depends on Ca2+ Influx via Reverse-Mode Activity of the Na+/Ca2+ Exchanger (2007) (121)
The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice. (2004) (119)
Gastrin-releasing peptide mediates photic entrainable signals to dorsal subsets of suprachiasmatic nucleus via induction of Period gene in mice. (2002) (119)
Ubiquitination of E3 ubiquitin ligase TRIM5α and its potential role (2008) (115)
A deficit of brain dystrophin impairs specific amygdala GABAergic transmission and enhances defensive behaviour in mice. (2009) (112)
PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration (2011) (111)
Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. (1992) (108)
Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant (2007) (104)
A Novel Allosteric Potentiator of AMPA Receptors: 4-[2-(Phenylsulfonylamino)ethylthio]-2,6-Difluoro-Phenoxyacetamide (1997) (103)
Direct uptake and degradation of DNA by lysosomes (2013) (102)
Optical Detection of Synaptically Induced Glutamate Transport in Hippocampal Slices (1999) (99)
Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions (2008) (99)
Developmental Regulation of Ubiquitin C-Terminal Hydrolase Isozyme Expression During Spermatogenesis in Mice (2004) (98)
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31 (2017) (94)
Facilitation of Extinction Learning for Contextual Fear Memory by PEPA: A Potentiator of AMPA Receptors (2007) (94)
Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor (1999) (91)
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. (2001) (89)
Differential Roles of Glial and Neuronal Glutamate Transporters in Purkinje Cell Synapses (2005) (89)
G-Protein-Coupled Receptor Screen Reveals a Role for Chemokine Receptor CCR5 in Suppressing Microglial Neurotoxicity (2008) (89)
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions (2011) (87)
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. (2008) (87)
Ubiquitin C-Terminal Hydrolase L-1 Is Essential for the Early Apoptotic Wave of Germinal Cells and for Sperm Quality Control During Spermatogenesis1 (2005) (86)
Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia (2004) (86)
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl‐terminal hydrolase L‐1, reveals oxidation of key proteins (2004) (84)
Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis. (2004) (84)
Dynamic changes in expression of glutamate transporter mRNAs in developing brain (1996) (84)
Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. (2004) (83)
Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease (2009) (82)
Multiple signal transduction pathways mediated by 5-HT receptors (2004) (79)
Generation and characterization of mice lacking gastrin-releasing peptide receptor. (1997) (79)
Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice. (2000) (78)
Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases. (2010) (78)
Maternal supply of BDNF to mouse fetal brain through the placenta (2009) (78)
Stargazin controls the pharmacology of AMPA receptor potentiators. (2006) (77)
Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse (1997) (73)
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation (2006) (73)
Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C‐terminal hydrolase L1 gene (2008) (72)
Pharmacological Discrimination of Extinction and Reconsolidation of Contextual Fear Memory by a Potentiator of AMPA Receptors (2009) (70)
Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy. (2006) (70)
Overexpression of ubiquitin carboxyl‐terminal hydrolase L1 arrests spermatogenesis in transgenic mice (2006) (70)
Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease. (2015) (70)
Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice (2000) (70)
Comparison of mice deficient in the high- or low-affinity neurotensin receptors, Ntsr1 or Ntsr2, reveals a novel function for Ntsr2 in thermal nociception (2004) (68)
Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases. (1998) (68)
Expression and function of bradykinin receptors in microglia. (2003) (67)
Tubulation with dental pulp cells promotes facial nerve regeneration in rats. (2008) (66)
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice. (2006) (63)
Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways (2003) (61)
Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice (2002) (60)
N‐Acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes (1992) (60)
Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer’s Disease (2019) (60)
The Nicotinic Acetylcholine Receptor Gene Family (1988) (60)
Effects of UCH‐L1 on α‐synuclein over‐expression mouse model of Parkinson’s disease (2009) (59)
Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms (2017) (59)
Immunohistochemical localization of gastrin-releasing peptide receptor in the mouse brain (2005) (58)
Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes (2016) (58)
TDP‐43 associates with stalled ribosomes and contributes to cell survival during cellular stress (2013) (57)
Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling. (2009) (57)
PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells (2007) (56)
Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells (2009) (56)
Expression of Two Glutamate Transporters, GLAST and EAAT4, in the Human Cerebellum: Their Correlation in Development and Neonatal Hypoxic-lschemic Damage (1998) (56)
Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies (2011) (55)
Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin. (2012) (54)
Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. (2006) (54)
Role of bombesin (BN)-like peptides/receptors in emotional behavior by comparison of three strains of BN-like peptide receptor knockout mice (2002) (53)
UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself. (2006) (53)
Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? (2003) (52)
Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference. (2015) (50)
Primary structure and expression of beta 2: a novel subunit of neuronal nicotinic acetylcholine receptors. (1988) (50)
Lysosomal degradation of intracellular nucleic acids-multiple autophagic pathways. (2016) (49)
Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3. (2002) (48)
Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. (2004) (48)
p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies* (2014) (48)
Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice (2000) (48)
Pathological role of lipid interaction with α-synuclein in Parkinson's disease (2018) (47)
[The ubiquitin-proteasome system and neurodegeneration]. (2001) (47)
Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. (2007) (46)
Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3. (1996) (45)
Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures (1998) (44)
Neurotrophic factor receptors in epiretinal membranes after human diabetic retinopathy. (2002) (43)
Hyperresponsiveness to Palatable and Aversive Taste Stimuli in Genetically Obese (Bombesin Receptor Subtype-3–Deficient) Mice (1999) (43)
Molecular cloning of two glutamate transporter subtypes from mouse brain. (1995) (43)
Albutensin A and complement C3a decrease food intake in mice (2002) (42)
Diverse NF-kappaB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopathy. (2004) (42)
Antibodies to a C‐terminal peptide of the rat brain glutamate receptor subunit, GluR‐A, recognize a subpopulation of AMPA binding sites but not kainate sites (1990) (42)
Sequence and expression of genes encoding the large and small subunits of ribulose 1,5-bisphosphate carboxylase/oxygenase from Chromatium vinosum. (1991) (41)
Insights into links between familial and sporadic Parkinson's disease: Physical relationship between UCH-L1 variants and chaperone-mediated autophagy (2008) (40)
α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies (2010) (40)
Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Mice via a Non-Cell Autonomous Mechanism (2012) (40)
Effect of β-lactotensin on acute stress and fear memory (2006) (39)
Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation Independently of Its Hydrolase Activity* (2013) (38)
Propofol-mediated impairment of CA1 long-term potentiation in mouse hippocampal slices (2005) (38)
Stress-induced impairment of inhibitory avoidance learning in female neuromedin B receptor-deficient mice (2003) (38)
Dexmedetomidine Reduces Long-term Potentiation in Mouse Hippocampus (2008) (37)
Neurotensin type 2 receptor is involved in fear memory in mice (2007) (37)
RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates (2015) (37)
Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model (2015) (37)
Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. (2006) (37)
Disruption of neuromedin B receptor gene results in dysregulation of the pituitary-thyroid axis. (2006) (36)
β-Lactotensin, a neurotensin agonist peptide derived from bovine β-lactoglobulin, enhances memory consolidation in mice (2007) (36)
Genes encoding neuronal nicotinic acetylcholine receptors. (1989) (36)
Multifunctional effects of bradykinin on glial cells in relation to potential anti-inflammatory effects (2007) (36)
Kinin receptors in cultured rat microglia (2004) (35)
N-acetylated-α-linked-acidic dipeptidase inhibitor has a neuroprotective effect on mouse retinal ganglion cells after pressure-induced ischemia (2000) (35)
An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding. (2015) (35)
Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions (2011) (35)
Bombesin and its family of peptides: prospects for the treatment of obesity. (2002) (34)
Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. (1993) (34)
A desensitization‐selective potentiator of AMPA‐type glutamate receptors (2002) (34)
Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes (2016) (34)
Male mice lacking the gastrin-releasing peptide receptor (GRP-R) display elevated preference for conspecific odors and increased social investigatory behaviors (2000) (34)
Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice (2017) (34)
Identification of an Axotomy-Induced Glycosylated Protein, AIGP1, Possibly Involved in Cell Death Triggered by Endoplasmic Reticulum–Golgi Stress (2002) (34)
Accumulation of β- and γ-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse (2004) (34)
β‐Lactotensin derived from bovine β‐lactoglobulin exhibits anxiolytic‐like activity as an agonist for neurotensin NTS2 receptor via activation of dopamine D1 receptor in mice (2011) (34)
Decreased marble burying behavior in female mice lacking neuromedin-B receptor (NMB-R) implies the involvement of NMB/NMB-R in 5-HT neuron function (2002) (33)
Supplemental Treatment for Huntington’s Disease with miR-132 that Is Deficient in Huntington’s Disease Brain (2018) (32)
Restraint stress impaired maternal behavior in female mice lacking the neuromedin B receptor (NMB-R) gene (2002) (32)
RNA levels of neuronal nicotinic acetylcholine receptor subunits are differentially regulated in axotomized facial motoneurons: an in situ hybridization study. (1990) (31)
Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors (2014) (31)
Functions of pancreatic beta cells and adipocytes in bombesin receptor subtype-3-deficient mice. (2004) (31)
Expression of glutamate transporter subtypes during normal human corticogenesis and type II lissencephaly. (2005) (31)
Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells (1997) (30)
Maternal enrichment affects prenatal hippocampal proliferation and open-field behaviors in female offspring mice (2009) (30)
Neurosphere generation from dental pulp of adult rat incisor (2008) (30)
GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF‐1‐induced ERK1/2 activation (2010) (30)
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system. (2012) (29)
Maternal high-fat diet leads to persistent synaptic instability in mouse offspring via oxidative stress during lactation (2016) (29)
Tailor-made RNAi knockdown against triplet repeat disease-causing alleles (2010) (29)
Inhibition of Protein Misfolding/Aggregation Using Polyglutamine Binding Peptide QBP1 as a Therapy for the Polyglutamine Diseases (2013) (29)
Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice (2001) (28)
Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin. (2009) (27)
Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways. (2004) (27)
Ubiquitin dimers control the hydrolase activity of UCH-L3 (2009) (27)
Dietary NaCl supplementation prevents muscle necrosis in a mouse model of Duchenne muscular dystrophy. (2006) (27)
TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase (2010) (26)
Disturbance in Maternal Environment Leads to Abnormal Synaptic Instability during Neuronal Circuitry Development (2017) (26)
Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse (2009) (26)
Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice (2003) (25)
Solo/Trio8, a Membrane-Associated Short Isoform of Trio, Modulates Endosome Dynamics andNeurite Elongation (2006) (25)
Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis. (2009) (25)
Light-Induced Retinal Degeneration Suppresses Developmental Progression of Flip-to-Flop Alternative Splicing in GluR1 (1998) (25)
Accumulation of beta- and gamma-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse. (2004) (24)
SIDT2 mediates gymnosis, the uptake of naked single-stranded oligonucleotides into living cells (2017) (24)
Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse. (2003) (24)
The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3) (2005) (24)
Expression of a glutamate transporter subtype, EAAT4, in the developing human cerebellum (1997) (24)
Parkin potentiates ATP‐induced currents due to activation of P2X receptors in PC12 cells (2006) (24)
Melanocortin receptor 4 is induced in nerve‐injured motor and sensory neurons of mouse (2007) (23)
Female gastrin-releasing peptide receptor (GRP-R)-deficient mice exhibit altered social preference for male conspecifics: implications for GRP/GRP-R modulation of GABAergic function (2001) (23)
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening (2010) (22)
Anti-inflammatory effects of kinins via microglia in the central nervous system (2006) (22)
Proadrenomedullin N‐terminal 20 peptide (PAMP) elevates blood glucose levels via bombesin receptor in mice (2000) (22)
Bombesin receptor subtype-3 modulates plasma insulin concentration (2003) (22)
Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes (2020) (22)
NF-κB in epiretinal membranes after human diabetic retinopathy (2003) (22)
Ubiquitin C‐terminal hydrolase‐L3‐knockout mice are resistant to diet‐induced obesity and show increased activation of AMP‐activated protein kinase in skeletal muscle (2009) (21)
Chronic stress-mutated presenilin 1 gene interaction perturbs neurogenesis and accelerates neurodegeneration (2010) (20)
4-Hydroxynonenal induces persistent insolubilization of TDP-43 and alters its intracellular localization. (2015) (20)
Stress induces insertion of calcium-permeable AMPA receptors in the OFC–BLA synapse and modulates emotional behaviours in mice (2020) (19)
Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene (2012) (19)
Deficiency of AMPAR–Palmitoylation Aggravates Seizure Susceptibility (2018) (19)
The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases (2011) (19)
Ro52-mediated Monoubiquitination of IKK b Down-regulates NF- i B Signalling (2009) (19)
Structure and function of neuronal nicotinic acetylcholine receptors deduced from cDNA clones. (1989) (19)
Activation of the VIP/VPAC2 system induces reactive astrocytosis associated with increased expression of glutamate transporters (2011) (18)
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses (2010) (18)
Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation (2010) (18)
Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity. (2010) (18)
Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3. (2001) (18)
Heightened Amygdala Long-Term Potentiation in Neurotensin Receptor Type-1 Knockout Mice (2008) (18)
A protocol for immunofluorescence staining of floating neurospheres (2010) (18)
Glutamate transporters in neonatal cerebellar subarachnoid hemorrhage. (2000) (17)
Endothelin/endothelin-B receptor signals regulate ventricle-directed interkinetic nuclear migration of cerebral cortical neural progenitors (2011) (17)
Facilitating actions of an AMPA receptor potentiator upon extinction of contextually conditioned fear response in stressed mice (2011) (17)
Proadrenomedullin N-terminal 20 peptide (PAMP) inhibits food intake and gastric emptying in mice (2001) (17)
Ghrelin alters postnatal endocrine secretion and behavior in mouse offspring (2009) (16)
Lack of neurotensin type 1 receptor facilitates contextual fear memory depending on the memory strength (2010) (16)
beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice. (2007) (16)
Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering. (2006) (15)
Isolation, localization, and cloning of a kainic acid binding protein from frog brain. (1990) (15)
Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala (2014) (15)
Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease (2013) (15)
Abnormal instability, excess density, and aberrant morphology of dendritic spines in prenatally testosterone-exposed mice (2015) (15)
Structural characterization and expression of a brain specific gene encoding chick kainate binding protein (1992) (15)
Effect of beta-lactotensin on acute stress and fear memory. (2006) (14)
Rational identification of a novel soy-derived anxiolytic-like undecapeptide acting via gut-brain axis after oral administration (2017) (14)
Reduction of abnormal behavioral response to brief restraint by information from other mice in dystrophin-deficient mdx mice (2010) (14)
Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice. (2019) (14)
The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis. (2006) (14)
Skeletal muscle fiber degeneration in mdx mice induced by electrical stimulation (1997) (14)
NF-kappaB in epiretinal membranes after human diabetic retinopathy. (2003) (14)
The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment (2001) (13)
Modulation of Long-Term Potentiation of Cortico-Amygdala Synaptic Responses and Auditory Fear Memory by Dietary Polyunsaturated Fatty Acid (2016) (13)
"Bio-communication" between mother and offspring: lessons from animals and new perspectives for brain science. (2009) (13)
Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation. (2020) (13)
Potentiation of ATP‐induced currents due to the activation of P2X receptors by ubiquitin carboxy‐terminal hydrolase L1 (2005) (13)
Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy (2017) (12)
Characterization of soy‐deprestatin, a novel orally active decapeptide that exerts antidepressant‐like effects via gut–brain communication (2017) (12)
Noradrenaline-induced spontaneous inhibitory postsynaptic currents in mouse basolateral nucleus of amygdala pyramidal neurons: Comparison with dopamine-induced currents (2010) (12)
Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease (2021) (11)
Impaired serum thyrotropin response to hypothyroidism in mice with disruption of neuromedin B receptor (2008) (11)
Specific inhibition of Huntington's disease gene expression by siRNAs in cultured cells. (2003) (11)
Maternal dietary restriction during lactation influences postnatal growth and behavior in the offspring of mice (2010) (11)
Cloning and characterization of the rat neurotensin receptor gene promoter. (1996) (10)
Property of lysosomal storage disease associated with midbrain pathology in the central nervous system of Lamp-2-deficient mice. (2015) (10)
[Function of glial G-protein coupled receptors]. (2007) (10)
Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter. (1997) (10)
A deletion in the second cytoplasmic loop of GluR3 produces a dominant negative mutant of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. (1994) (10)
Bombesin, obesity, and social behavior (1998) (10)
Mouse neurotensin receptor 2 gene (Ntsr2): genomic organization, transcriptional regulation and genetic mapping on chromosome 12. (2001) (10)
The Effect of a New Water-Soluble Sedative-Hypnotic Drug, JM-1232(−), on Long-Term Potentiation in the CA1 Region of the Mouse Hippocampus (2011) (9)
Abnormalities in synaptic dynamics during development in a mouse model of spinocerebellar ataxia type 1 (2015) (9)
Alpha 1-adrenoceptor agonists protect against stress-induced death of neural progenitor cells. (2007) (9)
Molecular cloning and characterization of the common marmoset huntingtin gene. (2009) (8)
Parkinson’s disease-associated mutations in α-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L1 (2011) (8)
Identification of a novel regulatory mechanism for norepinephrine transporter activity by the IP3 receptor. (2006) (8)
Function and subcellular location of Ro52β (2006) (8)
Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5. (1995) (8)
Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice: lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry (2013) (7)
Dominant negative mutant of ionotropic glutamate receptor subunit GluR3: implications for the role of a cysteine residue for its channel activity and pharmacological properties. (1997) (7)
Adult‐like action potential properties and abundant GABAergic synaptic responses in amygdala neurons from newborn marmosets (2012) (7)
Erratum: Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1 (Human Molecular Genetics (2008) vol. 17 (10) (1482-1496) 10.1093/hmg/ddn037) (2008) (7)
Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C‐terminal palmitoylation‐deficient mice (2018) (7)
Peptide-based therapeutic approaches for treatment of the polyglutamine diseases. (2014) (7)
Brain and Muscle Nicotinic Acetylcholine Receptors: A Gene Family (1989) (6)
Sequence analysis, tissue expression and chromosomal localization of a mouse secreted superoxide dismutase gene. (1997) (6)
Potentiating effects of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide (PEPA) on excitatory synaptic transmission in dentate granule cells (1999) (6)
Does Proteosome Inhibition Decrease or Accelerate Toxin-Induced Dopaminergic Neurodegeneration? (2005) (6)
Identification and functional characterization of mouse TPO1 as a myelin membrane protein (2006) (6)
Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids (2020) (6)
Function and subcellular location of Ro52beta. (2006) (6)
A comparative study of care practices for young boys with Duchenne muscular dystrophy between Japan and European countries: Implications of early diagnosis (2016) (5)
Molecular Biology of the Neural and Muscle Nicotinic Acetylcholine Receptors (1987) (5)
NMDAR2B tyrosine phosphorylation is involved in thermal nociception (2012) (4)
Genetic mapping of the mouse gene encoding dipeptidyl aminopeptidase-like proteins (2004) (4)
The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1 (2006) (4)
Research report Accumulation of h- and g-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse (2004) (3)
and for sperm quality control during spermatogenesis (2005) (3)
Common Hepatic Branch of Vagus Nerve-Dependent Expression of Immediate Early Genes in the Mouse Brain by Intraportal L-Arginine: Comparison with Cholecystokinin-8 (2017) (3)
Developmental changes of nerve growth factor levels in the gracile axonal dystrophy mouse (1994) (3)
Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming (2020) (3)
PATHOPHYSIOLOGICAL STUDY OF AXONAL DEGENERATION IN THE GRACILE AXONAL DYSTROPHY (GAD) MUTANT MOUSE (1994) (3)
Identification of break points in mutated PMP22 gene in a new Trembler (Tr-Ncnp) mouse. (1999) (3)
Virtual screening identification of novel chemical inhibitors for aberrant interactions between pathogenic mutant SOD1 and tubulin (2019) (3)
Association of ubiquitin carboxy-terminal hydrolase-L1 in cerebrospinal fluid with clinical severity in a cohort of patients with Guillain–Barré syndrome (2015) (2)
NMB-R-deficient mouse in the elevated plus maze (2002) (2)
Discovery of a protein uptake pathway in lysosomes (2020) (2)
Brain Nicotinic Acetylcholine Receptors: A Gene Family (1989) (2)
Alleviation of conditioned fear in mice fed with lipid extracts of Euphausia superba (2011) (2)
Bio-communication between mother and offspring (2011) (2)
Pharmacological discrimination of fear extinction and reconsolidation (2009) (2)
Does proteasome [corrected] inhibition decrease or accelerate toxin-induced dopaminergic neurodegeneration? (2005) (1)
P.418 Dental pulp cells for facial nerve regeneration (2008) (1)
NF-κB in epiretinal membranes after human diabetic retinopathy (2003) (1)
Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system (2020) (1)
A novel allosteric potentiator of AMPA receptors: PEPA (1998) (1)
YAC/BAC-based physical and transcript mapping around the gracile axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and Hip2 genes. (2000) (1)
Neurodegenerative Disorders as Systemic Diseases (2015) (1)
Maternal administration of the herbal medicine toki-shakuyaku-san promotes fetal growth and placental gene expression in normal mice. (2013) (1)
2328 Metabolic defects and development of obesity in BRS-3 deficient mice (1997) (1)
Clock genes regulate neurogenic transcription factors and the neuronal differentiation of adult neural stem/progenitor cells (2007) (0)
341 Targeted disruption of the glial glutamate transporter genes (1997) (0)
Touching base (1999) (0)
The LTP regulation system by D2 receptor and neurotensin receptor type-1 in the basolateral amygdala (2007) (0)
Erratum to “Bombesin and its family of peptides: prospects for the treatment of obesity” [Eur. J. Pharmacol. 440 (2002) 281–290] (2002) (0)
Establishment of novel Drosophila models of ALS expressing TDP-43, and analyses of its pathomechanisms (2010) (0)
miceafter gastric glucose in GRP receptor-deleted Reduced GLP-1 and insulin responses and glucose (2016) (0)
Direct uptake mechanism in lysosome required for neuromuscular homeostasis (2020) (0)
P.339 Dental pulp-derived neurospheres for peripheral nerve reconstruction (2006) (0)
Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) analyses of the initial aggregation process of tau by oxidative stress (2007) (0)
Accumulation of GAPDH enhances delayed neuronal cell death in LAMP-2 deficient mice (2009) (0)
Chronic stress arrests the maturation of hippocampal neuronal progenitors in mice overexpressing an AD type presenilin 1 (PS1) (2007) (0)
Nucleic acid uptake occurs independent of lysosomal acidification but dependent on ATP consumption during RNautophagy/DNautophagy. (2023) (0)
Roles of Multiple Types of Autophagy in Neurodegenerative Diseases (2014) (0)
Analysis of neuromedin B receptor function by using the NMB-R-deficient mice (1998) (0)
α-Synuclein Transgenic Drosophila As aModel of Parkinson ’ s Disease and Related (2014) (0)
Maternal life style affects the functional development of brain in the offspring: From the view of bio-communication (2010) (0)
Inhibition of Protein Misfolding/Aggregation Using Polyglutamine Binding Peptide QBP1 as a Therapy for the Polyglutamine Diseases (2013) (0)
An approach through gene-engineered animals (1998) (0)
Abnormal Aggregation of Brain Proteins and the Causing Neuropathic Diseases (2006) (0)
Poster Session: Ion channels (2004) (0)
Noradrenaline-induced spontaneous inhibitory postsynaptic currents in mouse basolateral nucleus of amygdala pyramidal neurons: Comparison with dopamine-induced currents (2011) (0)
Robo1 regulates the morphological development of pyramidal neurons in the mouse neocortex (2010) (0)
[Do lysosomes take up various macromolecules independently of membrane traffic?]. (2013) (0)
Short communication Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter 1 (1997) (0)
Amelioration of neurological phenotypes and inclusion body formation in polyglutamine disease mice upon AAV5-mediated expression of aggregate inhibitor molecules (2010) (0)
Sexually dimorphic gastrin-releasing peptide system in the lumbar spinal cord controls masculine reproductive functions in rats (2009) (0)
Inhibition de l'expression du gene de la maladie de huntington (2004) (0)
Pharmacological study of D-serine on activity of cloned NMDA receptors (1994) (0)
Different cellular mechanisms in microglial migration induced by ATP and neuropeptides (2008) (0)
Identification of a polyglutamine protein aggregation inhibitor QAI1 and its therapeutic effects on polyglutamine neurodegenerative diseases. (2020) (0)
Altered Emotional Behaviors in Mammalian Bombesin Receptor Knockout Mice: Implication for the Molecular Pathogenesis of Stress-Induced Psychiatric Disorders in Humans (2006) (0)
Nicotine receptor and amyloid burden for frontal activation in Alzheimer disease (0)
Inhibition de l'expression du gene de la huntingtine (2004) (0)
715 A deletion in the second cytoplasmic loop of glur3 produces a killar mutant of the ampa receptor (1993) (0)
910 Extrasynaptic localization of the glutamate transport EAAT4 at Purkinje cell synapses (1997) (0)
Distribution of the serum inducible kinase (Snk) mRNA in the rat nervous system: Its up-regulation in lateral and basolateral amygdala after cued fear conditioning (2007) (0)
Differential contributions of the two cell surface G‐protein coupled neurotensin (NT) receptors (NTr1 and NTr2) in open field accommodation (839.7) (2014) (0)
Lack of Neurotensin type1 receptor facilitates contextual fearmemory depending on the memory strength (2010) (0)
[Epilepsy and glutamate transporters: study of mice lacking a glutamate transporter and other recent advances]. (1998) (0)
202 Down-regulation of the glutamate transporter glut-1 in bergmann astroglia of mutant cerebella with impaired parallel fiber- purkinje cell synapse formation (1996) (0)
Aggravation of neurodegeneration by high-nutrient diet in Drosophila models of neurodegenerative diseases (2011) (0)
Identification of novel UCH-L1-potentiating compounds by in silico drug screening (2007) (0)
Synaptic regulatory mechanism of ubiquitin C-terminal hydrolase L1 (2011) (0)
Effects of a novel potentiator of ampa receptors, 4-[2-(phenylsulfonyl-amino)ethylthio]-2,6-difluoro-phenoxyacetamide (PEPA) on excitatory synaptic transmission in rat dentate gyrus (1998) (0)
LAMP-2 deficient mice brain as a model for lysosomal storage disease (2009) (0)
Medial prefrontal cortex is involved in extinction learning for recent but not remote contextual fear (2007) (0)
FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD (2022) (0)
[Perspectives on postgenome medicine: Neurodegenerative disease]. (2001) (0)
Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention (2020) (0)

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What Schools Are Affiliated With Keiji Wada?

Keiji Wada is affiliated with the following schools:

Hokkaido University
MD Anderson Cancer Center