Keith D. Robertson
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Keith D. Robertsoncomputer-science Degrees
Computer Science
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Computational Linguistics
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Machine Learning
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Computer Science
Keith D. Robertson's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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Why Is Keith D. Robertson Influential?
(Suggest an Edit or Addition)Keith D. Robertson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DNA methylation and human disease (2005) (2558)
- DNA methylation in health and disease (2000) (1103)
- DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters (2000) (987)
- The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. (1999) (865)
- DNA methylation, methyltransferases, and cancer (2001) (760)
- Histone Deacetylase Inhibitors for Cancer Therapy (2006) (733)
- DNA methylation: past, present and future directions. (2000) (600)
- DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011) (546)
- DNA methylation and chromatin – unraveling the tangled web (2002) (492)
- The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53 (1998) (393)
- DNA methyltransferases, DNA damage repair, and cancer. (2013) (372)
- DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3B (2007) (332)
- Chromatin remodeling, histone modifications, and DNA methylation—how does it all fit together? (2002) (316)
- DNA methylation in development and human disease. (2008) (259)
- Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD) (2009) (254)
- Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. (2000) (227)
- DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. (2008) (226)
- Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. (2012) (224)
- Human DNA Methyltransferase 1 Is Required for Maintenance of the Histone H3 Modification Pattern* (2004) (204)
- Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. (2006) (194)
- SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities (2011) (190)
- Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue. (1998) (177)
- Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. (2006) (159)
- Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. (2002) (158)
- Preferential Methylation of Unmethylated DNA by Mammaliande Novo DNA Methyltransferase Dnmt3a* (2002) (152)
- Roles of Cell Division and Gene Transcription in the Methylation of CpG Islands (1999) (141)
- Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. (2004) (140)
- Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial (1995) (137)
- Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer (2007) (137)
- DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. (2009) (132)
- Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors. (2004) (129)
- DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. (2004) (128)
- Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. (2004) (127)
- Methylation status of the Epstein-Barr virus major latent promoter C in iatrogenic B cell lymphoproliferative disease. Application of PCR-based analysis. (1999) (112)
- DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. (2009) (110)
- Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus (1999) (108)
- Doxorubicin Inhibits DNMT1, Resulting in Conditional Apoptosis (2004) (106)
- The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas (2007) (102)
- Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. (2011) (100)
- Epigenetic mechanisms and genome stability (2010) (98)
- DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma. (2011) (98)
- Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression. (2006) (97)
- Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. (2012) (97)
- Stealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection. (2003) (95)
- Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells (2014) (91)
- DNA methylation and the Epstein-Barr virus. (1999) (89)
- Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro. (2004) (84)
- A Novel DNMT3B Splice Variant Expressed in Tumor and Pluripotent Cells Modulates Genomic DNA Methylation Patterns and Displays Altered DNA Binding (2009) (83)
- The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive (1998) (76)
- Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants (2011) (75)
- CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease. (1996) (75)
- Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy (2007) (74)
- The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. (2000) (71)
- Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues (2018) (68)
- Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis (2014) (67)
- DNA methylation age is accelerated in alcohol dependence (2018) (65)
- Methylation of the Epstein-Barr virus genome in normal lymphocytes. (1997) (63)
- DNMT1 knockout delivers a strong blow to genome stability and cell viability (2007) (62)
- Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing (2011) (62)
- Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma. (1996) (61)
- Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)—a study of 1084 patients (2019) (61)
- An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. (2006) (61)
- Comparative epigenomics of human and mouse mammary tumors (2009) (60)
- Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials (2016) (59)
- Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3. (2011) (56)
- Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas (2008) (55)
- Molecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure (2012) (55)
- Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma (2019) (55)
- Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA (2019) (50)
- Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter (1997) (47)
- Slow progressive conduction and contraction defects in loss of Nkx2–5 mice after cardiomyocyte terminal differentiation (2009) (46)
- Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma (2015) (45)
- Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome. (2014) (42)
- High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver (2017) (41)
- Epigenetic control of tumor suppression. (2007) (41)
- Number and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevance (2016) (39)
- ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation (2018) (37)
- The transglutaminase 2 gene is aberrantly hypermethylated in glioma (2011) (35)
- Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application (2017) (34)
- Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis. (2021) (33)
- RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis (2021) (29)
- DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma (2019) (28)
- The role of DNA methylation in modulating Epstein-Barr virus gene expression. (2000) (27)
- DNA methyltransferase 3 B ( DNMT 3 B ) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development , neurogenesis and immune function (2008) (27)
- Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation. (2018) (25)
- Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro. (2004) (23)
- A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma. (2017) (21)
- Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer (2017) (21)
- Genetic and Epigenetic Heterogeneity in Normal Liver Homeostasis and Its Implications for Liver Disease and Hepatocellular Cancer (2018) (21)
- Dynamic interrelationships between DNA replication, methylation, and repair. (1997) (20)
- Small Molecule Inhibitor YM155-Mediated Activation of Death Receptor 5 Is Crucial for Chemotherapy-Induced Apoptosis in Pancreatic Carcinoma (2014) (19)
- Alpha‐1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity (2019) (18)
- Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis (2018) (17)
- DNA Methyltransferases (DNMTs), DNA Damage Repair, and Cancer (2013) (16)
- CpGtools: a python package for DNA methylation analysis (2019) (15)
- DMB (DNMT-Magnetic Beads) Assay (2004) (14)
- A Three‐Pronged Epigenetic Approach to the Treatment of Hepatocellular Carcinoma (2018) (13)
- Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder (2019) (13)
- Pharmacologic activation of expression of immunodominant viral antigens: a new strategy for the treatment of Epstein-Barr-virus-associated malignancies. (1995) (12)
- Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq (2019) (12)
- Role of DNA Methylation in Genome Stability (2016) (11)
- The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC (2020) (11)
- DMB (DNMT-magnetic beads) assay: measuring DNA methyltransferase activity in vitro. (2004) (10)
- Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome (2014) (9)
- Epigenetic Mechanisms of Gene Regulation (2005) (8)
- Nucleosome positioning changes during human embryonic stem cell differentiation (2016) (8)
- Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer (2021) (7)
- Interferon drives HCV scarring of the epigenome and creates targetable vulnerabilities following viral clearance (2021) (7)
- The DNA methylation inhibitor 5‐aza‐2′‐deoxycytidine (5‐azadC) induces reversible genome‐wide DNA damage that is distinctly influenced by DNA methyltransferases (DNMTs) 1 and 3B (2007) (6)
- Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma (2017) (5)
- CAME: identification of chromatin accessibility from nucleosome occupancy and methylome sequencing (2016) (5)
- Epigenetics of gastrointestinal diseases: notes from a workshop (2018) (4)
- Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia (2022) (4)
- Phenotypic correlates and prognostic outcomes of TET2 mutations in myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: A comprehensive study of 504 adult patients (2020) (3)
- In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma (2019) (3)
- Unique Clinical Epidemiologic Risk Factors Are Associated with Distinct Methylation Subgroups in Newly-Diagnosed Acute Myeloid Leukemia (AML) (2016) (2)
- Missteps in "tango" for epigenome targeting. (2009) (2)
- Plasma Cell-Free DNA Methylomics of Bipolar Disorder With and Without Rapid Cycling (2021) (2)
- Use of the CRISPR/Cas9‐based epigenetic gene activation system In Vivo: A new potential therapeutic modality (2018) (2)
- RAS mutations drive proliferative chronic myelomonocytic leukemia via activation of a novel KMT2A-PLK1 axis (2019) (2)
- Misregulation of DNA Methylation Regulators in Cancer (2017) (2)
- Number and Type of TET2 Mutations in Chronic Myelomonocytic Leukemia: Clinical and Prognostic Correlates (2016) (2)
- Abstract 5180: Enhanced and controlled chromatin extraction for chromatin-based epigenetic assays in FFPE tissues (2019) (1)
- SHP2 inhibition enhances Yes-associated protein–mediated liver regeneration in murine partial hepatectomy models (2022) (1)
- Abstract 2305: Acute depletion reveals novel co-regulation of DNA methylation at conserved loci by DNMT1 and DNMT3B (2014) (1)
- Use of Chromatin Changes as Biomarkers (2016) (1)
- Bioinformatics Strategies for Identifying Regions of Epigenetic Deregulation Associated with Aberrant Transcript Splicing and RNA-editing (2015) (1)
- Abstract 2319: Dynamics of TET methylcytosine dioxygenases in 5-methylcytosine and 5-hydroxymethylcytosine patterning in human cancer cells (2014) (1)
- Resource Linking DNAMethyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells (2012) (1)
- Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells (2014) (1)
- Abstract 17: Tumor-suppressive function of SLC5A8 in renal cancer cells (2012) (1)
- Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials (2016) (1)
- Abstract 806: Enhancer deregulation inTET2-mutant clonal hematopoiesis is associated with increased COVID-19 severity and mortality (2023) (0)
- Clonal Compositions Involving Epigenetic Regulator Gene Mutations in Clonal Hematopoiesis, Clonal Cytopenias of Undetermined Significance and Chronic Myelomonocytic Leukemia (2021) (0)
- Glioma Aberrant DNA Methylation-Mediated Silencing in Malignant Epigenomic Profiling Reveals Novel and Frequent Targets of Updated (2006) (0)
- Clinical Categorization of Chronic Myelomonocytic Leukemia into Proliferative and Dysplastic Subtypes Correlates with Distinct Genomic, Transcriptomic and Epigenomic Signatures (2019) (0)
- ASXL1-Mutant Chronic Myelomonocytic Leukemia Is Associated with Increased Intratumoral Heterogeneity and Single-Cell Chromatin Co-Accessibility (2020) (0)
- Epigenetic regulation of homeobox genes in liver cancer (2011) (0)
- Abstract 2970: Acute depletion of DNA methyltransferases reveals unique and overlapping target sites in cancer. (2013) (0)
- Abstract 1054: The role of DNMT1 in the DNA damage response (2012) (0)
- Abstract 1226: SETD2 loss in renal epithelial cells induces epithelial to mesenchymal transition in a TGFβ-independent manner (2023) (0)
- Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues (2018) (0)
- Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome (2023) (0)
- Abstract 4874: Epigenetic gene silencing is co-regulated by DNMT3B and polycomb-mediated histone modifications in human cancer (2010) (0)
- Frequently Hypermethylated in Human Tumor Cells Epidermal Growth Factor and Follistatin Domains Is The Gene for a Novel Transmembrane Protein Containing Updated (2000) (0)
- Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application (2018) (0)
- Inside Lab Invest (2009) (0)
- FREE with the March issue of Trends in Molecular Medicine (2002) (0)
- Burkitt's lymphoma and Hodgkin's disease CpG methylation of the major Epstein-Barr virus latency promoter in (2009) (0)
- Phenotypic Correlates and Prognostic Outcomes of TET2 Mutations in Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes: A Comprehensive Study of 504 Patients (2019) (0)
- Su1503 - The Evolution of Dna Methylation Changes in Nonalcoholic Fatty Liver Disease to Cirrhosis and Liver Cancer (2018) (0)
- Abstract 4868: Interaction between DNMT3B and polycomb repression complexes and their role in histone modification (2010) (0)
- Novel circulating cell free DNA methylation alterations as a biomarker for the detection of hepatocellular carcinoma (2017) (0)
- Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application (2017) (0)
- IFN-γ activates p300 to over-ride silencing effects of DNA methylation to activate GPR109A and SLC5A8 transcription (P2105) (2013) (0)
- DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma (2019) (0)
- Abstract 5009: Identification of DNA methyltransferase target sites in cancer cells (2012) (0)
- Abstract B34: Acute depletion reveals novel divisions of labor among human DNA methyltransferases in cancer (2013) (0)
- Sequence analysis CpGtools: a python package for DNA methylation analysis (2021) (0)
- Abstract 1666: Deciphering the role of TGFβ in regulating transcriptome and DNA methylome during EMT to identify therapeutic targets for clear cell renal cell carcinoma (2023) (0)
- Response to Epigenetic Disruption in Tumor Suppressor of Hepatocellular Carcinoma (HCC) (2020) (0)
- Title Isolation and characterization of a novel DNA methyltransferase complex linking DNMT 3 B with components of the mitotic chromosome condensation machinery Permalink (2004) (0)
- Erratum (2017) (0)
- Multistage epigenome-wide association study identifies highly accurate epigenomic signatures in association with hepatocellular carcinoma: The HCC epigenome score (2022) (0)
- Effects of Alcohol metabolism on Hepatocellular carcinoma progression (2015) (0)
- Titration-based normalization of antibody amount improves consistency of ChIP-seq experiments (2023) (0)
- Abstract 145: Interactions among DNA methyltransferase isoforms and their effects on DNA methylation (2010) (0)
- Association of Clinical Epidemiologic Exposures and Overall Survival with Genome-Wide DNA Methylation Profiles in Acute Myeloid Leukemia: Analysis of the Mayo Clinic AML Epidemiology Cohort (2018) (0)
- Indoleamine 2,3-Dioxygenase-1 Expressing Dendritic Cell Populations Are Associated with Tumor-Induced Immune Tolerance & Aggressive Disease Biology in Chronic Myelomonocytic Leukemia (2018) (0)
- Abstract LB-235: DNA methylation of individual repetitive elements in HCV infection-induced HCC (2018) (0)
- Abstract 2309: Identification of common and unique epigenetic signatures of chronic hepatitis infection and alcohol abuse in human liver disease (2014) (0)
- Epigenetic memory of environmental exposures as a mediator of liver disease. (2023) (0)
- Abstract 485: Role of DNA methyltransferase I (DNMT1) in the DNA damage response (2010) (0)
- Enhancer deregulation in TET2 Mutant Clonal Hematopoiesis is associated with increased COVID-19 related inflammation severity and mortality (2022) (0)
- METHYLATION AND HUMAN DISEASE (0)
- iTagPlot: an accurate computation and interactive drawing tool for tag density plot (2015) (0)
- Distal Enhancer Elements in ASXL1-Mutant Chronic Myelomonocytic Leukemia (2019) (0)
- Gene Body Methylation and Transcriptional Activity in ASXL1-Mutant Chronic Myelomonocytic Leukemia (2020) (0)
- Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer (2021) (0)
- Epigenetic Mechanisms of Gene Regulation: Relationships between DNA Methylation, Histone Modification, and Chromatin Structure (2005) (0)
- Genome-Wide DNA Methylomics in Bipolar Disorder (2021) (0)
- Abstract 996: MBD-capture coupled with next generation sequencing elucidates genome-wide crosstalk between epigenetic marks and its role in cancer (2012) (0)
- Distinguishing Active Versus Passive DNA Demethylation Using Illumina MethylationEPIC BeadChip Microarrays. (2021) (0)
- Epigenomic Determinants of Transcriptional Activity in ASXL1-Mutant Chronic Myelomonocytic Leukemia (2019) (0)
- Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq (2019) (0)
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What Schools Are Affiliated With Keith D. Robertson?
Keith D. Robertson is affiliated with the following schools:
