Keith D. Wilkinson
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Keith D. Wilkinsonbiology Degrees
Biology
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#16353
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Neuroscience
#2188
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#2249
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Biochemistry
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#2367
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Biology
Keith D. Wilkinson's Degrees
- PhD Biochemistry University of California, San Diego
- Bachelors Chemistry University of California, San Diego
Why Is Keith D. Wilkinson Influential?
(Suggest an Edit or Addition)Keith D. Wilkinson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The ubiquitin pathway in Parkinson's disease (1998) (1615)
- Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. (2009) (1279)
- Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome (2001) (1102)
- The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. (1989) (854)
- FMR1 protein: conserved RNP family domains and selective RNA binding. (1993) (742)
- BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression (1998) (678)
- Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes (1997) (622)
- Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. (2000) (582)
- Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009) (572)
- Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. (2002) (501)
- A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 (2001) (472)
- The fragile X mental retardation protein inhibits translation via interacting with mRNA. (2001) (467)
- Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14 (2005) (395)
- Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. (1998) (395)
- Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases (1990) (357)
- Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes. (1980) (346)
- BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. (2008) (313)
- The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin (2006) (304)
- Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. (1995) (288)
- Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function* (2004) (268)
- In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome (1997) (251)
- Crystal structure of a deubiquitinating enzyme (human UCH‐L3) at 1.8 å resolution (1997) (225)
- Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths* (1997) (218)
- Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins (2004) (199)
- Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues. (1996) (194)
- Identification and Characterization of DEN1, a Deneddylase of the ULP Family* (2003) (190)
- Purified Recombinant Fmrp Exhibits Selective RNA Binding as an Intrinsic Property of the Fragile X Mental Retardation Protein* (1998) (189)
- DEN1 Is a Dual Function Protease Capable of Processing the C Terminus of Nedd8 and Deconjugating Hyper-neddylated CUL1* (2003) (189)
- Protein partners of deubiquitinating enzymes. (2008) (186)
- Regulation of proteolysis by human deubiquitinating enzymes. (2014) (170)
- Hsp70 Chaperones as Modulators of Prion Life Cycle (2005) (166)
- SUSP1 antagonizes formation of highly SUMO2/3-conjugated species (2006) (154)
- Human genes containing polymorphic trinucleotide repeats (1992) (152)
- Polyubiquitin binding and cross‐reactivity in the USP domain deubiquitinase USP21 (2011) (147)
- β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 (2009) (144)
- Roles of ubiquitinylation in proteolysis and cellular regulation. (1995) (144)
- Comparison of the three-dimensional structures of human, yeast, and oat ubiquitin. (1987) (141)
- Polyubiquitin binding and disassembly by deubiquitinating enzymes. (2009) (137)
- Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases. (1992) (136)
- Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. (2009) (134)
- Ubiquitin–proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells (2005) (130)
- An -N-acetyl-D-glycosamine binding lectin from Bandeiraea simplicifolia seeds. (1976) (127)
- Three-dimensional structure of ubiquitin at 2.8 A resolution. (1985) (126)
- Pleiotropic Effects of Ubp6 Loss on Drug Sensitivities and Yeast Prion Are Due to Depletion of the Free Ubiquitin Pool* (2003) (124)
- An Emerging Model for BAP1’s Role in Regulating Cell Cycle Progression (2011) (124)
- Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities (2008) (121)
- Stimulation of ATP-dependent proteolysis requires ubiquitin with the COOH-terminal sequence Arg-Gly-Gly. (1981) (120)
- Recognition of Polyubiquitin Isoforms by the Multiple Ubiquitin Binding Modules of Isopeptidase T* (2008) (120)
- Detection, resolution, and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus. (1989) (118)
- The discovery of ubiquitin-dependent proteolysis (2005) (112)
- DUBs at a glance (2009) (109)
- Proteolytic Processing and Deubiquitinating Activity of Papain-Like Proteases of Human Coronavirus NL63 (2007) (108)
- Structural Basis for Ubiquitin Recognition by the Otu1 Ovarian Tumor Domain Protein* (2008) (108)
- Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases (2008) (101)
- Distribution and paralogue specificity of mammalian deSUMOylating enzymes. (2010) (92)
- Alcohol-induced conformational changes of ubiquitin. (1986) (90)
- Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton. (2011) (84)
- Ubiquitin-dependent signaling: the role of ubiquitination in the response of cells to their environment. (1999) (84)
- Doa1 Is a Cdc48 Adapter That Possesses a Novel Ubiquitin Binding Domain (2006) (84)
- Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation. (2000) (83)
- Effects of Ubiquitin System Alterations on the Formation and Loss of a Yeast Prion*♦ (2007) (82)
- Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. (2005) (76)
- Methodology employed for anaerobic spectrophotometric titrations and for computer-assisted data analysis. (1979) (72)
- A suggestion for naming faces of ring compounds. (1980) (71)
- Derivitization of the C-terminus of ubiquitin and ubiquitin-like proteins using intein chemistry: methods and uses. (2005) (69)
- Structure and recognition of polyubiquitin chains of different lengths and linkage (2011) (65)
- Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates (2015) (62)
- Physiological and environmental control of yeast prions. (2014) (60)
- Prions, Chaperones, and Proteostasis in Yeast. (2017) (57)
- Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). (2008) (57)
- Racemization of Individual Aspartate Residues in Human Myelin Basic Protein (1988) (54)
- Signal transduction: Aspirin, ubiquitin and cancer (2003) (53)
- Burkholderia mallei tssM Encodes a Putative Deubiquitinase That Is Secreted and Expressed inside Infected RAW 264.7 Murine Macrophages (2009) (52)
- The large scale purification of ubiquitin from human erythrocytes. (1985) (51)
- Divergent N-terminal Sequences of a Deubiquitinating Enzyme Modulate Substrate Specificity* (2001) (50)
- Dynamic Compartmentalization of Base Excision Repair Proteins in Response to Nuclear and Mitochondrial Oxidative Stress (2008) (49)
- Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase. (1986) (49)
- The Deubiquitinating Enzymes (2008) (48)
- BAP1 is phosphorylated at serine 592 in S‐phase following DNA damage (2013) (44)
- Two ZnF-UBP domains in isopeptidase T (USP5). (2012) (44)
- Quantitative analysis of protein-protein interactions. (2015) (43)
- Modulating huntingtin half‐life alters polyglutamine‐dependent aggregate formation and cell toxicity (2004) (42)
- Identification of a novel 29-linked polyubiquitin binding protein, Ufd3, using polyubiquitin chain analogues. (2004) (41)
- Isotope trapping studies of yeast hexokinase during steady state catalysis. A combined rapid quench and isotope trapping technique. (1979) (40)
- The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. (1999) (39)
- Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress. (2017) (38)
- Evidence for multiple electronic forms of two-electron-reduced lipoamide dehydrogenase from Escherichia coli. (1979) (37)
- Protein ubiquitination: a regulatory post-translational modification. (1987) (33)
- The ubiquitin signal: assembly, recognition and termination (2005) (32)
- NADH inhibition and NAD activation of Escherichia coli lipoamide dehydrogenase catalyzing the NADH-lipoamide reaction. (1981) (32)
- Structure and activities of a variant ubiquitin sequence from bakers' yeast. (1986) (31)
- Purification and Structural Properties of Ubiquitin (1988) (30)
- Tryptic peptide mapping of ubiquitin and derivatives using reverse-phase high performance liquid chromatography. (1986) (28)
- Stress-dependent Proteolytic Processing of the Actin Assembly Protein Lsb1 Modulates a Yeast Prion* (2014) (27)
- A specific inhibitor of the ubiquitin activating enzyme: synthesis and characterization of adenosyl-phospho-ubiquitinol, a nonhydrolyzable ubiquitin adenylate analogue. (1990) (26)
- Ubiquitin-dependent proteolysis of native and alkylated bovine serum albumin: effects of protein structure and ATP concentration on selectivity. (1985) (22)
- Deubiquitinating enzyme purification, assay inhibitors, and characterization. (2005) (21)
- Identification and Developmental Expression of Xenopus laevis SUMO Proteases (2009) (20)
- Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009) (20)
- Prion-based memory of heat stress in yeast (2017) (18)
- Role of ubiquitin conformations in the specificity of protein degradation: iodinated derivatives with altered conformations and activities. (1986) (18)
- Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery (2019) (17)
- Functional Requirements of the Active Site Position 185 in the Human Enzyme Galactose-1-phosphate Uridylyltransferase* (1996) (17)
- Structure and function of ubiquitin: evidence for differential interactions of arginine-74 with the activating enzyme and the proteases of ATP-dependent proteolysis. (1987) (16)
- The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling. (2005) (15)
- Functional Consequence of Substitutions at Residue 171 in Human Galactose-1-phosphate Uridylyltransferase* (2000) (13)
- Detection and inhibition of ubiquitin-dependent proteolysis. (1990) (12)
- Glucose exchange and catalysis by two crystalline hexokinase x glucose complexes. Evidence for an obligatory ATP-dependent conformational change in catalysis. (1980) (12)
- Nucleolar protein B 23 / nucleophosmin regulates the vertebrate SUMO pathway through SENP 3 and SENP 5 proteases (2008) (11)
- Activation of yeast hexokinase PII. Changes in conformation and association. (1979) (10)
- Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases. (1989) (10)
- BAP1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization (9)
- Cell biology: Unchaining the condemned (2002) (8)
- Probing the structure of processed antigen by using biotin and avidin. MHC-dependent inhibition of responses to selected biotinyl-insulin derivatives. (1989) (8)
- Quantitative analysis of protein-protein interactions. (2004) (7)
- Study of crystalline hexokinase-glucose complexes by isotope trapping. (1981) (7)
- Immobilization of proteins via arginine residues. (1987) (7)
- Cellular Regulation by Ubiquitin-Dependent Processes (1998) (5)
- Interactions of guanidinium chloride and pyridine nucleotides with oxidized and two-electron-reduced lipoamide dehydrogenase from Escherichia coli. (1979) (5)
- OTU takes the chains OUT. (2008) (4)
- Varshavsky's Contributions (2004) (4)
- DeTEKting Ubiquitination of APC/C Substrates (2008) (4)
- Corrigendum: Human genes containing polymorphic trinucleotide repeats (1993) (2)
- Erratum: Human genes containing polymorphic trinucleotide repeats (Nature Genetics 2, 186-191 (1992)) (1993) (2)
- Author response: Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates (2015) (2)
- Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association (2020) (2)
- Specificity of Ubiquitin-Binding Proteins: Recognition of Different Faces of Ubiquitin (2006) (1)
- Identification of Mammalian SUMO‐specific Ubiquitin‐like Processing Proteases (SENP/Ulp) (2006) (1)
- Depletion of the Free Ubiquitin Pool Sensitivities and Yeast Prion Are Due to Pleiotropic Effects of Ubp6 Loss on Drug Modification, and Degradation: Protein Synthesis, Post-Translation (2003) (0)
- Burkholderia Mallei tssM Encodes a Secreted Deubiquitinase that is Expressed Inside Infected RAW 264.7 Murine Macrophages (2008) (0)
- Structure of the ZNF UBP domain from deubiquitinating enzyme isopeptidase T (IsoT) (2006) (0)
- Yeast Prion the Actin Assembly Protein Lsb 1 Stress-dependent Proteolytic Processing of Molecular Bases of Disease : (2014) (0)
- Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin (2006) (0)
- crystal structure of linear di-ubiquitin (2009) (0)
- 125I-ubiquitin is kinetically invalid as a tracer radiolabel for studies of ATP-dependent proteolysis. (1985) (0)
- Faculty Opinions recommendation of Recent advances in polyubiquitin chain recognition. (2011) (0)
- Quantitation of Binding 15 15 From : Methods in Molecular Biology (2017) (0)
- Irwin Allan Rose (1926–2015) (2015) (0)
- Crystal Structure of Den1 in complex with Nedd8 (2004) (0)
- Activation of Yeast Hexokinase PI 1 CHANGES (2002) (0)
- Faculty Opinions recommendation of An additional role for SUMO in ubiquitin-mediated proteolysis. (2011) (0)
- Polyubiquitin Binding and Disassembly by Deubiquitinating Enzymes (2009) (0)
- Structure of USP21 in complex with linear diubiquitin-aldehyde (2012) (0)
- Faculty Opinions recommendation of Properties of natural and artificial proteins displaying multiple ubiquitin-binding domains. (2011) (0)
- Paralog specificity of mammalian SENPs for SUMO‐1 and SUMO‐2 (2008) (0)
- Faculty Opinions recommendation of Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. (2011) (0)
- Racemization of individual amino acid residues in membrane proteins. (1989) (0)
- Faculty Opinions recommendation of K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. (2011) (0)
- Prion formation in yeast is influenced by alterations of the ubiquitin proteolysis (2008) (0)
- Recent Advances in Nutritional Sciences Ubiquitin-Dependent Signaling : The Role of Ubiquitination in the Response of Cells to Their Environment . 1 (1999) (0)
- Faculty Opinions recommendation of The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease. (2011) (0)
- Faculty Opinions recommendation of Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2. (2011) (0)
- Otu Takes the Chains out Nature Chemical Biology Volume 4 Number 4 April 2008 2 2 7 (0)
- Faculty Opinions recommendation of Ubiquitin-binding domains and their role in the DNA damage response. (2011) (0)
- Faculty Opinions recommendation of Direct activation of protein kinases by unanchored polyubiquitin chains. (2011) (0)
- Faculty Opinions recommendation of Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. (2011) (0)
- The ZnF UBP domain is a novel ubiquitin‐binding domain that recognizes the C‐terminal di‐glycine motif of unanchored ubiquitin (2006) (0)
- Faculty Opinions recommendation of Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. (2011) (0)
- Faculty Opinions recommendation of Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease. (2011) (0)
- Substrate specificity of ubiquitin dependent protein degradation (1983) (0)
- Faculty Opinions recommendation of Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. (2011) (0)
- Faculty Opinions recommendation of Traceless and site-specific ubiquitination of recombinant proteins. (2011) (0)
- DEUBIQUITINATING ENZYME UCH-L3 (HUMAN) AT 1.8 ANGSTROM RESOLUTION (1998) (0)
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