Keith Matthews
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British parasitologist
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Biology
Keith Matthews 's Degrees
- Bachelors Biology University of Oxford
- PhD Parasitology Imperial College London
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(Suggest an Edit or Addition)According to Wikipedia, Keith Roland Matthews, , , is a British cell biologist and parasitologist, currently Professor of Parasite Biology in the School of Biological Sciences at the University of Edinburgh. His research focuses on African trypanosomes , which cause human sleeping sickness and the equivalent cattle disease nagana.
Keith Matthews 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Genome of the Kinetoplastid Parasite, Leishmania major (2005) (1355)
- The developmental cell biology of Trypanosoma brucei (2005) (323)
- A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei. (1996) (286)
- A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. (1994) (261)
- A surface transporter family conveys the trypanosome differentiation signal (2009) (217)
- Temporal order of RNA-processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcripts (1993) (197)
- Genome wide dissection of the quorum sensing signaling pathway in Trypanosoma brucei (2013) (191)
- The cell biology of Trypanosoma brucei differentiation. (2007) (165)
- Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes (1994) (150)
- Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei (2009) (140)
- A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway. (2010) (121)
- Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act (2012) (117)
- Drug resistance in eukaryotic microorganisms (2016) (115)
- Protein tyrosine phosphatase TbPTP1: a molecular switch controlling life cycle differentiation in trypanosomes (2006) (109)
- Transmission Stages Dominate Trypanosome Within-Host Dynamics during Chronic Infections (2011) (104)
- A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form (2001) (101)
- Flagellar Morphogenesis: Protein Targeting and Assembly in the Paraflagellar Rod of Trypanosomes (1999) (101)
- Molecular regulation of the life cycle of African trypanosomes. (2004) (100)
- Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels (2014) (95)
- Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome (2006) (92)
- Differential Trypanosome Surface Coat Regulation by a CCCH Protein That Co-Associates with procyclin mRNA cis-Elements (2009) (92)
- The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains (2007) (91)
- Controlling and Coordinating Development in Vector-Transmitted Parasites (2011) (91)
- Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei: evidence for genome-wide conservation of life-cycle stage-specific regulatory elements (2006) (86)
- Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing (2019) (84)
- The paraflagellar rod of kinetoplastida: solved and unsolved questions. (1996) (83)
- Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei (2013) (81)
- Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated. (1995) (81)
- Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei (2013) (76)
- Activation of Endocytosis as an Adaptation to the Mammalian Host by Trypanosomes (2007) (72)
- Developments in the differentiation of Trypanosoma brucei. (1999) (68)
- Identification and Stage-specific Association with the Translational Apparatus of TbZFP3, a CCCH Protein That Promotes Trypanosome Life-cycle Development* (2006) (65)
- The within-host dynamics of African trypanosome infections (2015) (65)
- The cell cycle in protozoan parasites. (2000) (64)
- Regulation of surface coat exchange by differentiating African trypanosomes. (2006) (63)
- Assembling the components of the quorum sensing pathway in African trypanosomes (2015) (61)
- Characterisation of the growth and differentiation in vivo and in vitro-of bloodstream-form Trypanosoma brucei strain TREU 927. (2001) (61)
- The bloodstream differentiation–division of Trypanosoma brucei studied using mitochondrial markers (1997) (59)
- 25 years of African trypanosome research: From description to molecular dissection and new drug discovery☆☆☆ (2015) (56)
- The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation (2010) (54)
- Cycles within cycles: the interplay between differentiation and cell division in Trypanosoma brucei. (1994) (53)
- The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei (2011) (51)
- The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream (2017) (51)
- Anisomorphic cell division by African trypanosomes. (2001) (50)
- Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form. (1997) (50)
- Molecular control of irreversible bistability during trypanosome developmental commitment (2015) (44)
- tbCPSF30 Depletion by RNA Interference Disrupts Polycistronic RNA Processing in Trypanosoma brucei* (2003) (44)
- Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation‐enriched CCCH protein (2005) (44)
- A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome. (2000) (43)
- Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes (1990) (42)
- Limitation of Trypanosoma brucei parasitaemia results from density-dependent parasite differentiation and parasite killing by the host immune response (2001) (42)
- Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression (2016) (42)
- Isolation of Trypanosoma brucei CYC2 andCYC3 Cyclin Genes by Rescue of a Yeast G1Cyclin Mutant (2000) (42)
- Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form. (1998) (41)
- Functional Characterisation and Drug Target Validation of a Mitotic Kinesin-13 in Trypanosoma brucei (2010) (41)
- A novel ERK‐like, CRK‐like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C‐terminal extension (2004) (41)
- Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host (2013) (40)
- Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei (2018) (39)
- Malaria and trypanosome transmission: different parasites, same rules? (2011) (39)
- Interspecies quorum-sensing in co-infections can manipulate trypanosome transmission potential (2017) (38)
- Targeting pathogen metabolism without collateral damage to the host (2017) (36)
- Independent Pathways Can Transduce the Life-Cycle Differentiation Signal in Trypanosoma brucei (2013) (35)
- A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development (2018) (35)
- Mitochondrial development during life cycle differentiation of African trypanosomes: evidence for a kinetoplast-dependent differentiation control point. (2002) (34)
- Stable transformation of pleomorphic bloodstream form Trypanosoma brucei. (2013) (33)
- Duplicative activation mechanisms of two trypanosome telomeric VSG genes with structurally simple 5' flanks. (1990) (33)
- Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels (2001) (30)
- ADVANCES IN MICROBIAL SYSTEMS BIOLOGY (2014) (30)
- Identification of the regulatory elements controlling the transmission stage-specific gene expression of PAD1 in Trypanosoma brucei (2012) (30)
- The silicon trypanosome (2010) (29)
- Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes (2018) (29)
- Isolates of Trichuris muris elicit different adaptive immune responses in their murine host (2005) (28)
- A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle. (2004) (27)
- NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway (2015) (27)
- New discoveries in the transmission biology of sleeping sickness parasites: applying the basics (2010) (27)
- Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei. (2006) (26)
- Emerging challenges in understanding trypanosome antigenic variation (2017) (26)
- Regulation of Genetically Engineered Microorganisms Under FIFRA, FFDCA and TSCA (2012) (26)
- An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri (2017) (25)
- Harnessing evolutionary biology to combat infectious disease (2012) (25)
- Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing (2021) (25)
- Life-cycle differentiation in Trypanosoma brucei: molecules and mutants. (2000) (25)
- A Leap Into the Unknown - Early Events in African Trypanosome Transmission. (2020) (24)
- A reproducible protocol for analysis of the proteome of Trypanosoma brucei by 2-dimensional gel electrophoresis. (2003) (24)
- Impact of the functional status of saeRS on in vivo phenotypes of Staphylococcus aureus sarA mutants (2014) (24)
- Quorum sensing in African trypanosomes. (2019) (23)
- Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods (2018) (23)
- The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis. (2012) (21)
- African trypanosomes (2019) (21)
- Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei (2017) (20)
- Targeting Cattle-Borne Zoonoses and Cattle Pathogens Using a Novel Trypanosomatid-Based Delivery System (2011) (20)
- An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei (2019) (20)
- Cell-cycle synchronisation of bloodstream forms of Trypanosoma brucei using Vybrant DyeCycle Violet-based sorting. (2010) (19)
- Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms (2010) (19)
- Stage-specific mechanisms for activation and expression of variant surface glycoprotein genes in Trypanosoma brucei. (1990) (18)
- A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination (2021) (16)
- Trypanosoma brucei brucei: Endocytic recycling is important for mouse infectivity (2011) (15)
- Trypanosoma brucei: unusual expression-site-associated gene homologies in a metacyclic VSG gene expression site. (1993) (15)
- A short bifunctional element operates to positively or negatively regulate ESAG9 expression in different developmental forms of Trypanosoma brucei (2013) (14)
- High-Throughput Chemical Screening for Antivirulence Developmental Phenotypes in Trypanosoma brucei (2014) (14)
- Restless gossamers: antibody clearance by hydrodynamic flow forces generated at the surface of motile trypanosome parasites. (2007) (14)
- Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes—A Quantitative Redox Proteome and Thiol Analysis (2017) (13)
- Trypanosome Signaling-Quorum Sensing. (2021) (13)
- The Trypanosome Rab-Related Proteins RabX1 and RabX2 Play No Role in IntraCellular Trafficking but May Be Involved in Fly Infectivity (2009) (12)
- Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei (2007) (10)
- Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation (2019) (10)
- Application of single-cell transcriptomics to kinetoplastid research (2021) (9)
- Monomorphic Trypanozoon: towards reconciling phylogeny and pathologies (2021) (8)
- Investigating Mammalian Tyrosine Phosphatase Inhibitors as Potential ‘Piggyback’ Leads to Target Trypanosoma brucei Transmission (2013) (7)
- The silicon trypanosome: a test case of iterative model extension in systems biology. (2014) (6)
- Modelling trypanosome chronicity: VSG dynasties and parasite density. (2008) (5)
- Comment on ‘Unexpected plasticity in the life cycle of Trypanosoma brucei’ (2022) (5)
- Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei (2019) (5)
- Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts (2022) (3)
- The genomic basis of host and vector specificity in non-pathogenic trypanosomatids (2022) (3)
- Identification of a LIM domain-containing gene in the Cyathostominae. (2008) (3)
- The application of genomic technology to combat parasitic disease (2004) (3)
- Parasite co-infection: an ecological, molecular and experimental perspective (2022) (2)
- Cayla et al., 2020, Wellcome Open Research - Underlying data (2020) (2)
- Cayla et al., 2020, Wellcome Open Research - Extented data (2020) (2)
- Comparative Sensitivity and Specificity of the 7SL sRNA Diagnostic Test for Animal Trypanosomiasis (2022) (2)
- Cayla et al., 2020, Wellcome Open Research - Code availability (2020) (2)
- Extracellular release of two peptidases dominates generation of the trypanosome quorum-sensing signal (2021) (2)
- Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics (2023) (1)
- Short communication Genetic nomenclature for Trypanosoma and Leishmania (1998) (1)
- Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro (2021) (1)
- Chapter 4Regulation of Genetically EngineeredMicroorganisms Under FIFRA,FFDCA and TSCA (2012) (1)
- A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation. (2020) (1)
- Life-cycle differentiation in Trypanosoma brucei (2000) (1)
- TrAGEDy: Trajectory Alignment of Gene Expression Dynamics (2022) (1)
- INVESTIGATIONS INTO THE INITIATION AND CONTROL OF LIFECYCLE DIFFERENTIATION OF AFRICAN TRYPANOSOMES (2000) (0)
- Abstract 1347: Quorum sensing and developmental mechanisms in African Trypanosomes (2023) (0)
- Assembling the components of the quorum sensing pathway in African 1 trypanosomes 1 2 3 (2015) (0)
- Molecular control of differentiation during the life cycle of T. brucei (2000) (0)
- A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation (2020) (0)
- PRIMER African trypanosomes (2019) (0)
- University of Groningen The silicon trypanosome (2017) (0)
- The Trypanosomiases, Ian Maudlin, Peter Holmes, Michael Miles (Eds.). CABI Publishing (2004), £99.50 (614 pages), ISBN: 085199475X (2005) (0)
- Explorer NMD 3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway (2015) (0)
- Oligopeptide Signaling through Tb GPR 89 Drives Trypanosome Quorum Sensing Graphical Abstract Highlights (2018) (0)
- Metacyclic VSG gene activation in Trypanosoma brucei rhodesiense (1990) (0)
- Protein tyrosine phosphatase TbPTP 1 (2006) (0)
- Use it or lose it: The function of mitochondrial DNA in trypanosomes (2016) (0)
- African trypanosomes (2019) (0)
- When is a slender not a slender? The cell-cycle arrest and scarcity of slender parasites challenges the role of bloodstream trypanosomes in infection maintenance (2023) (0)
- Distinguishing functions of trypanosomatid protein kinases. (2022) (0)
- Targeting new drugs with choline metabolism. (2012) (0)
- Edinburgh Research Explorer The silicon trypanosome (2018) (0)
- trypanosomes.of tubulin polycistronic pre-mRNA in A common pyrimidine-rich motif governs trans-splicing and (2011) (0)
- Mitochondrial imporet and developmental stage-regulation of Cytochrome Oxidase VI in African trypanosomes (2000) (0)
- Single cell transcriptomic analysis of bloodstream form Trypanosoma brucei reconstructs cell cycle progression and differentiation via quorum sensing (2020) (0)
- 35 years of molecular and biochemical parasitology. (2014) (0)
- Obtaining the full sequence of the genome of two plants trypanosomatids (2012) (0)
- The SPARC complex defines RNAPII promoters in Trypanosoma brucei (2022) (0)
- Cycles within cycles (1994) (0)
- Correction: Corrigendum: Drug resistance in eukaryotic microorganisms (2016) (0)
- Protein Phosphatases in Trypanosome Growth and Development (2013) (0)
- Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression (2016) (0)
- Edinburgh Research Explorer Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels (2018) (0)
- Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei (2018) (0)
- Edinburgh Research Explorer Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma (2018) (0)
- Analysis of the proteome during differentiation events in the African trypanosome (2000) (0)
- Interspecies quorum sensing in co-infections can manipulate trypanosome transmission potential (2017) (0)
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