Ken-ichi Kosaka
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Ken-ichi Kosakaphilosophy Degrees
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Medical Philosophy
Ken-ichi Kosaka's Degrees
- Doctorate Medicine University of Tokyo
- PhD Neurology University of Tokyo
Why Is Ken-ichi Kosaka Influential?
(Suggest an Edit or Addition)Ken-ichi Kosaka's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Diagnosis and management of dementia with Lewy bodies (2005) (3346)
- Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. (1996) (2280)
- Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) (1996) (2138)
- Diagnosis and management of dementia with Lewy bodies (2017) (1606)
- Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease? (1984) (432)
- Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases (2002) (357)
- DLB and PDD boundary issues (2007) (351)
- Concurrence of TDP-43, tau and α-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies (2007) (337)
- Changes of Biogenic Amines and Their Metabolites in Postmortem Brains from Patients with Alzheimer‐Type Dementia (1984) (315)
- The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. (2007) (222)
- Donepezil for Dementia with Lewy Bodies: A Randomized, Placebo-Controlled Trial (2012) (208)
- Diffuse lewy body disease in Japan (1990) (189)
- Lewy bodies in cerebral cortex. Report of three cases (1978) (163)
- SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians (2013) (161)
- Angiotensin-Converting Enzyme Converts Amyloid β-Protein 1–42 (Aβ1–42) to Aβ1–40, and Its Inhibition Enhances Brain Aβ Deposition (2007) (136)
- Expression of CD40 in the brain of Alzheimer’s disease and other neurological diseases (2000) (131)
- Fas antigen expression in brains of patients with Alzheimer-type dementia (1995) (131)
- Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies (2002) (129)
- A duplicated PLP gene causing Pelizaeus-Merzbacher disease detected by comparative multiplex PCR. (1996) (125)
- Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study (2015) (121)
- Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray. (2001) (116)
- Methamphetamine in Japan: the consequences of methamphetamine abuse as a function of route of administration. (2002) (114)
- Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type (1986) (109)
- Diffuse neurofibrillary tangles with calcification: a new presenile dementia. (1994) (108)
- Presenile dementia with Alzheimer-, Pick- and Lewy-body changes (1976) (99)
- Autonomic dysfunctions in dementia with Lewy bodies (2003) (94)
- Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells (2001) (94)
- Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition. (2007) (91)
- Diffuse Lewy body disease. (1995) (89)
- Brain site‐specific gene expression analysis in Alzheimer's disease patients (2006) (83)
- Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies (2002) (82)
- Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease (2009) (82)
- Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review (1996) (78)
- Somatostatin and vasoactive intestinal polypeptide in postmortem brains from patients with Alzheimer-type dementia (1984) (78)
- Dementia and neuropathology in Lewy body disease. (1993) (78)
- Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies (2003) (73)
- Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial (2015) (70)
- Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease (1998) (68)
- Dementia with Lewy bodies from the perspective of tauopathy (2003) (68)
- Alterations of muscarinic acetylcholine receptor subtypes in diffuse Lewy body disease: relation to Alzheimer’s disease (1999) (68)
- Membrane Topology of Alzheimer’s Disease-related Presenilin 1 (1999) (68)
- Subtype analysis of neuropathologically diagnosed patients in a Japanese geriatric hospital (2002) (67)
- Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease (1999) (66)
- Occurrence of human α-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer’s disease (2000) (66)
- Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer’s disease (2004) (64)
- Long-Term Safety and Efficacy of Donepezil in Patients with Dementia with Lewy Bodies: Results from a 52-Week, Open-Label, Multicenter Extension Study (2013) (64)
- A preliminary study of free amino acids in the postmorten temporal cortex from Alzheimer-type dementia patients (1984) (63)
- Cerebral type of Lewy body disease (1996) (63)
- Serum ghrelin concentrations in patients receiving olanzapine or risperidone (2004) (63)
- Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies (2001) (60)
- Efficacy and safety of donepezil in patients with dementia with Lewy bodies: Preliminary findings from an open‐label study (2006) (58)
- Neuropathological study of the amygdala in presenile Alzheimer's disease (1990) (57)
- Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia (2010) (57)
- Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain (2004) (56)
- 6‐Pyruvoyl‐tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: A clinical and molecular study (1997) (56)
- Clinical features of argyrophilic grain disease: a retrospective survey of cases with neuropsychiatric symptoms. (2005) (56)
- Central nervous system changes in mitochondrial encephalomyopathy: light and electron microscopic study (2004) (56)
- Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies (2011) (55)
- Extrahypophyseal distribution of α-melanocyte stimulating hormone (α-MSH)-like immunoreactivity in postmortem brains from normal subjects and Alzheimer-type dementia patients (1986) (54)
- The formation of prostaglandins in the postmortem cerebral cortex of Alzheimer-type dementia patients (1989) (53)
- Identification of hippocampus‐related candidate genes for Alzheimer's disease (2005) (53)
- Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using α-synuclein-immunohistochemistry (2000) (52)
- Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies (2003) (52)
- Distribution of m1 muscarinic acetylcholine receptors in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies—an immunohistochemical study (2001) (52)
- Novel nonsense proteolipid protein gene mutation as a cause of X-linked spastic paraplegia in twin males. (1995) (50)
- A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes (2006) (49)
- Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies (2006) (49)
- Ethnicity‐dependent genetic association of ABCA2 with sporadic Alzheimer's disease (2006) (48)
- Serum adiponectin concentrations during treatment with olanzapine or risperidone: a pilot study (2004) (45)
- Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine (2012) (45)
- Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders (1995) (44)
- Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies (2006) (44)
- Activation of vascular endothelial cells and perivascular cells by systemic inflammation—an immunohistochemical study of postmortem human brain tissues (2004) (44)
- Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues (2001) (43)
- Neuronal accumulation of &agr;- and &bgr;-synucleins in the brain of a GM2 gangliosidosis mouse model (2003) (43)
- 4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy (2003) (41)
- Variations in the BDNF Gene in Autopsy-Confirmed Alzheimer’s Disease and Dementia with Lewy Bodies in Japan (2006) (41)
- Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of Phase III trial (2015) (40)
- Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia (2006) (40)
- Association in Japanese patients between neuroleptic malignant syndrome and functional polymorphisms of the dopamine D2 receptor gene (2003) (40)
- Quantitative EEG in patients with presenile and senile dementia of the Alzheimer type (1994) (40)
- Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies (1998) (40)
- Clinical Aspects of ‘Senile Dementia of the Tangle Type’ – A Subset of Dementia in the Senium Separable from Late-Onset Alzheimer’s Disease (1998) (39)
- Adjunct zonisamide to levodopa for DLB parkinsonism (2018) (39)
- Dementia-parkinsonism syndrome with numerous lewy bodies and senile plaques in cerebral cortex (1979) (39)
- Characterizing the new transcription regulator protein p60TRP (2004) (38)
- Depressive disorder due to mitochondrial transfer RNALeu(UUR) mutation (1997) (38)
- SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease. (2013) (37)
- Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains (2000) (37)
- Psychomotor retardation correlates with frontal hypoperfusion and the Modified Stroop Test in patients with major depression under 60‐years‐old (2004) (37)
- Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions (2004) (37)
- Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy (1995) (37)
- Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia (2002) (35)
- A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies (2001) (35)
- Dementia with Lewy Bodies: Diffuse Lewy body disease within the spectrum of Lewy body disease (1996) (34)
- Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) and diabetes mellitus: molecular genetic analysis and family study (1993) (34)
- Decreased ventilatory response to hypercapnia in dementia with Lewy bodies (2009) (34)
- 123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study (2018) (34)
- Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease (2000) (33)
- Brain imaging of affective disorders and schizophrenia (1998) (33)
- Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia (2003) (32)
- Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies (2007) (32)
- Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model. (2003) (32)
- Clinicopathological studies on diffuse Lewy body disease (2000) (29)
- Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. (2004) (29)
- Non‐uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies (2005) (29)
- A non-alcoholic Japanese patient with Wernicke's encephalopathy and Marchiafava-Bignami disease. (1984) (29)
- Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease (1997) (28)
- Neuropathological evaluation and apolipoprotein E gene polymorphism analysis in diffuse Lewy body disease (1996) (28)
- An autopsy case of Alzheimer's disease presenting with primary progressive aphasia: A clinicopathological and immunohistochemical study (2000) (28)
- Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains (2002) (28)
- Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-ε4 carriers (2008) (27)
- Lack of association in Japanese patients between neuroleptic malignant syndrome and the TaqI A polymorphism of the dopamine D2 receptor gene (2003) (27)
- Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies (2014) (27)
- Prediction of outcomes in MCI with 123I-IMP-CBF SPECT: a multicenter prospective cohort study (2013) (27)
- Free amino acids in post-mortem cerebral cortices from patients with Alzheimer-type dementia (1985) (27)
- Lewy body disease and dementia with Lewy bodies (2014) (27)
- [A cliniconeurophathological study of the "Lewy body disease"]. (1980) (27)
- Close relationship between spongiform change and ubiquitin-positive granular structures in diffuse Lewy body disease (1997) (26)
- Selective loss of nigral neurons in Alzheimer's disease: a morphometric study (2004) (26)
- Distribution and morphology of brain stem plaques in Alzheimer's disease (2004) (26)
- Psychomotor retardation correlates with frontal hypoperfusion and the Modified Stroop Test in patients under 60-years-old with major depression. (2004) (26)
- Clinicopathological multiplicity of dementia with Lewy bodies (1999) (25)
- Evaluation of Probable or Possible Dementia with Lewy Bodies Using 123I-IMP Brain Perfusion SPECT, 123I-MIBG, and 99mTc-MIBI Myocardial SPECT (2007) (25)
- Pelizaeus‐Merzbacher disease: Three novel mutations and implication for locus heterogeneity (1999) (25)
- Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease. (2000) (24)
- Accumulation of NACP/α-synuclein in Lewy body disease and multiple system atrophy (2000) (24)
- Neurotransmitter changes in early- and late-onset Alzheimer-type dementia. (1992) (24)
- Japanese Creutzfeldt-Jakob disease patients exhibiting high incidence of the E200K PRNP mutation and located in the basin of a river. (1998) (23)
- A pathological study of Lewy bodies and senile changes in the amygdala in diffuse Lewy body disease (1995) (23)
- Age-related ubiquitin-positive granular structures in non-demented subjects and neurodegenerative disorders (1996) (23)
- Dementia with Lewy bodies. (1996) (23)
- Striatopallidonigral degeneration in Pick's disease: a clinicopathological study of 41 cases (1991) (23)
- Nasu-Hakola's disease (membranous lipodystrophy) (1981) (22)
- Ultrastructural and immunohistochemical study of degenerate neurite-bearing ghost tangles (1992) (21)
- Lack of association between neuroleptic malignant syndrome and polymorphisms in the 5-HT1A and 5-HT2A receptor genes. (1998) (21)
- No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies (2001) (21)
- Senile plaque-like structures: observation of a probably unknown type of senile plaque by periodic-acid methenamine silver (PAM) electron microscopy (2004) (21)
- Effect of zonisamide on parkinsonism in patients with dementia with Lewy bodies: A phase 3 randomized clinical trial. (2019) (21)
- Regional quantitative analysis of NFT in brains of non‐demented elderly persons: Comparisons with findings in brains of late‐onset Alzheimer’s disease and limbic NFT dementia (2002) (20)
- Recent advances in dementia research in Japan: Non‐Alzheimer‐type degenerative dementias (1998) (20)
- TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction (2004) (20)
- OPEN LABEL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF YOKUKANSAN, A TRADITIONAL ASIAN MEDICINE, IN DEMENTIA WITH LEWY BODIES (2011) (19)
- Progressive supranuclear palsy with fronto-temporal atrophy and various tau-positive abnormal structures. (1996) (19)
- Localization of serotonin immunoreactivity in cephalopod visual system (1990) (19)
- Morphological and biochemical changes in the cholinergic and monoaminergic systems in Alzheimer-type dementia (2004) (19)
- Alzheimer-type pathology in melanin-bleached sections of substantia nigra (1995) (19)
- Latest concept of Lewy body disease (2014) (19)
- Plasmid-based gene transfer ameliorates visceral storage in a mouse model of Sandhoff disease (2003) (19)
- Behavioral and psychological symptoms of dementia (BPSD) in dementia with Lewy bodies (2008) (19)
- Staining senile plaques using Bodian's method modified with methenamine. (1993) (18)
- Hereditary multisystemic degeneration with unusual combination of cerebellipetal, dentato-rubral, and nigro-subthalamo-pallidal degenerations. (1983) (18)
- Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions (2007) (17)
- Prolactin levels in schizophrenic patients receiving perospirone in comparison to risperidone. (2003) (17)
- Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix. (2005) (17)
- Accumulated α-synuclein affects the progression of GM2 gangliosidoses (2015) (17)
- Cerebrospinal fluid manganese concentrations in patients with symmetric pallidal hyperintensities on T1 weighted MRI (1999) (17)
- Diffuse Lewy body disease (2000) (17)
- Neuroleptic malignant syndrome induced by donepezil. (2004) (17)
- Hippocampal pathology in diffuse Lewy body disease using ubiquitin immunohistochemistry (1997) (17)
- [Content validity and inter-rater reliability of the Cognitive Fluctuation Inventory]. (2014) (17)
- Methenamine-silver staining: a simple and sensitive staining method for senile plaques and neurofibrillary tangles. (1994) (16)
- 123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies (2017) (16)
- Treatment of hypervascular small hepatocellular carcinoma with ultrasound-guided percutaneous acetic acid injection: comparison with segmental transcatheter arterial embolization. (1996) (16)
- Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial (2016) (16)
- Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM1 membranous ganglioside (1990) (16)
- Immunohistochemical study of synphilin-1 in brains of patients with dementia with Lewy bodies – synphilin-1 is non-specifically implicated in the formation of different neuronal cytoskeletal inclusions (2002) (16)
- Anti-ganglioside GD1a monoclonal antibody recognizes senile plaques in the brains of patients with Alzheimer-type dementia (1993) (16)
- Clinicopathological Study of Two Subtypes of Pick’s Disease in Japan (2002) (16)
- A novel missense mutation (G209R) in exon 8 of the presenilin 1 gene in a Japanese family with presenile familial Alzheimer's disease (1999) (16)
- Alterations of muscarinic acetylcholine receptors in atypical Pick’s disease without Pick bodies (2003) (15)
- [A new type of complicated form of hereditary spastic paraplegia showing mental deterioration, quadriplegia with muscular atrophy, sensory disturbance, extrapyramidal disorders, and epilepsy]. (1991) (15)
- Lack of association in Japanese patients between neuroleptic malignant syndrome and a debrisoquine 4-hydroxylase genotype with low enzyme activity. (2000) (15)
- Accumulation of human α-synuclein in different cytoskeletons in Lewy bodies in brains of dementia with Lewy bodies (2000) (15)
- Diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease) in Japan (2016) (14)
- [Distribution of Pick bodies in the central nervous system of Pick's disease with special reference to their association with neuronal loss]. (1987) (14)
- Characterizing CGI‐94 (comparative gene identification‐94) which is down‐regulated in the hippocampus of early stage Alzheimer's disease brain (2002) (14)
- Pallido-nigro-luysial atrophy with massive appearance of corpora amylacea in the CNS (2004) (14)
- Reversible conformational change of tau2 epitope on exposure to detergent in glial cytoplasmic inclusions of multiple system atrophy (2003) (14)
- Longitudinal study on MRI intensity changes of Machado–Joseph disease: correlation between MRI findings and neuropathological changes (2011) (14)
- Effects of Donepezil on Extrapyramidal Symptoms in Patients with Dementia with Lewy Bodies: A Secondary Pooled Analysis of Two Randomized-Controlled and Two Open-Label Long-Term Extension Studies (2015) (14)
- A computed tomography study of Alzheimer's disease (2004) (14)
- Vascular complications in dementia with Lewy bodies: A postmortem study (2006) (13)
- Yamaguchi fox–pigeon imitation test (YFPIT) for dementia in clinical practice (2011) (13)
- Transient lesion in the splenium of the corpus callosum, possibly due to carbamazepine (2003) (13)
- Dementia with Lewy bodies showing advanced Lewy pathology but minimal Alzheimer pathology--Lewy pathology causes neuronal loss inducing progressive dementia. (2002) (13)
- [A biochemical study of cholinergic neurons of the post-mortem brains from the patients with Alzheimer-type dementia]. (1984) (13)
- [Familial early onset cerebellar ataxia with hypoalbuminemia]. (1995) (13)
- Pretreatment Cognitive Profile Likely to Benefit from Donepezil Treatment in Dementia with Lewy Bodies: Pooled Analyses of Two Randomized Controlled Trials (2016) (12)
- Regional quantitative study of formation process of neurofibrillary tangles in the hippocampus of non‐demented elderly brains: Comparison with late‐onset Alzheimer's disease brains (2002) (12)
- [An autopsy case of complicated form of spastic paraplegia with amyotrophy, mental deficiency, sensory impairment, and parkinsonism]. (1990) (12)
- Degeneration of tyrosine hydroxylase-immunoreactive neurons in the cerebral cortex and hippocampus of patients with dementia with Lewy bodies (2003) (12)
- Ubiquitin and ubiquitin‐related proteins in neurons and dendrites of brains of atypical Pick's disease without Pick bodies (2004) (11)
- A patient with treatment‐resistant schizophrenia and cytochrome P4502D6 gene duplication (2002) (11)
- Gray matter lesions in Nasu‐Hakola disease: A report on three autopsy cases (2011) (11)
- Increased dosage of donepezil for the management of behavioural and psychological symptoms of dementia in dementia with Lewy bodies (2016) (11)
- Selective loss of nigral neurons in Pick's disease: a morphometric study (2004) (11)
- Regional quantitative analysis of tau-positive neurons in progressive supranuclear palsy: Comparison with Alzheimer's disease (1998) (11)
- Incidence and Distribution of Senile Plaques and Neurofibrillary Tangles in Late‐onset Diffuse Lewy Body Disease (1994) (11)
- Psychiatric symptoms typical of patients with dementia with Lewy bodies – similarity to those of levodopa-induced psychosis (2002) (11)
- Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or CYP2D6B (1997) (11)
- Similarity of symptoms between transient epileptic amnesia and Lewy body disease (2017) (11)
- Mutations in the Proteolipid Protein Gene in Japanese Families with Pelizaeus-Merzbacher Disease (1997) (11)
- [A case of general paresis with marked improvement of cerebral blood flow after antiluetic therapy--case report]. (1992) (10)
- Neuropathological study on the nucleus basalis of Meynert in Pick's disease (2004) (10)
- Pancreatic exocrine dysfunction associated with mitochondrial tRNA(Leu)(UUR) mutation. (1998) (10)
- Carbohydrate metabolism of the murine leprosy bacillus. I. Studies on the respiratory enzyme system, especially the diaphorase and malic dehydrogenase activities. (1961) (10)
- A manic episode associated with bereavement in a patient with lung cancer (2000) (9)
- Efficacy of open‐system social skills training in inpatients with mood, neurotic and eating disorders (2003) (9)
- A case of depressive disorder with neuronal heterotopia (1998) (9)
- Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians (2013) (9)
- Adult type of neuronal ceroid-lipofuscinosis with retinal involvement. (1984) (8)
- An autopsied case of juvenile parkinsonism and dementia, with a widespread occurrence of Lewy bodies and spheroids. (1992) (8)
- [A case with late-onset MELAS with hallucination and delusion]. (2004) (8)
- Post-traumatic stress disorder associated with suspected lung cancer and bereavement: 4-year follow-up and review of the literature (2003) (8)
- Parvalbumin-immunoreactive neurons in the cortex in Pick's disease (1991) (8)
- Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease (2005) (8)
- Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome (1998) (8)
- Recent advances in dementia research in Japan: Alzheimer‐type dementia (1999) (8)
- Normal sequences of muscarinic acetylcholine receptors (m1 and m2) in patients with Alzheimer's disease and vascular dementia (1994) (8)
- A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt–Jakob disease (2010) (8)
- Ubiquitin and ubiquitin‐related proteins in the brains of patients with atypical Pick's disease without Pick bodies and dementia with motor neuron disease (2004) (8)
- [A computed tomography study of Pick's disease]. (1984) (7)
- A Combination of Alzheimer's and Binswanger's Diseases —A Clinicopathological Study of Four Cases— (1986) (7)
- Pelizaeus‐Merzbacher disease: A novel mutation in the 5′‐untranslated region of the proteolipid protein gene (1996) (7)
- Neuropathological Investigation of Regions Responsible for Semantic Aphasia in Frontotemporal Lobar Degeneration (2009) (7)
- Autopsy case of concurrent Huntington's disease and neurofibromatosis type 1 (2014) (7)
- [Study on argyrophilic inclusions of multisystem atrophy (Oppenheimer)]. (1991) (7)
- Neuroleptic malignant syndrome following BMT (2002) (7)
- Clinical profiles of autopsy‐confirmed dementia with Lewy bodies at institutionalization: Comparison with Alzheimer’s disease (2007) (7)
- Novel acceptor splice site mutation in the invariant AG of intron 6 of α‐galactosidase A gene, causing Fabry disease (1998) (7)
- Adequacy of Using Consensus Guidelines for Diagnosis of Dementia with Lewy Bodies in Clinical Trials for Drug Development (2015) (6)
- The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies (2005) (6)
- The splicing regulatory protein p18SRP is down-regulated in alzheimer’s disease brain (2007) (6)
- [Some problems on the clinical phenotype of Machado-Joseph disease in relation between their ages at onset]. (1993) (6)
- An immunohistochemical study of β-protein in Alzheimer-type dementia brains (1989) (6)
- Presenile non‐Alzheimer dementia with motor neuron disease and laminar spongiform degeneration (1998) (6)
- Experimental Studies on the Resistance of the Rice Weevil, Calandra oryzae L., to Heat. II. Lethal Effects of Heat upon the Larvae and Pupae. (1943) (6)
- Heparan sulfate proteoglycans recognize ghost Pick bodies (1998) (6)
- Clinical and genetic evaluation of Japanese autosomal dominant cerebellar ataxias; is Machado-Joseph disease common in the Japanese? (1996) (6)
- Extrahypophyseal distribution of alpha-melanocyte stimulating hormone (alpha-MSH)-like immunoreactivity in postmortem brains from normal subjects and Alzheimer-type dementia patients. (1986) (6)
- The first autopsied case of diffuse Lewy body disease (DLBD): re‐examination by recent immunostaining methods (2010) (6)
- IMMUNOHISTOCHEMICAL AND IMMUNOELECTRON MICROSCOPICAL INVESTIGATION OF TAU-POSITIVE NEURONS LACKING TANGLE-FORMATION IN PROGRESSIVE SUPRANUCLEAR PALSY (1998) (5)
- An autopsied case of Down syndrome with Alzheimer pathology and α‐synuclein immunoreactivity (1999) (5)
- Evaluation of Neuropathological Stages Based on Quantification of Senile Changes in Non‐Demented Elderly Individuals and Alzheimer‐Type Dementia (1993) (5)
- Novel acceptor splice site mutation in the invariant AG of intron 6 of alpha-galactosidase A gene, causing Fabry disease. Mutations in brief no. 146. Online. (1998) (5)
- A novel alternative splice variant of nicastrin and its implication in Alzheimer disease. (2006) (5)
- Multiple system degeneration involving thalamus, reticular formation, pallido-nigral, pallido-Luysian and dentato-rubral systems (1977) (5)
- BRAIN IMAGING IN PSYCHIATRY (1994) (5)
- Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes (2012) (5)
- Detection by Nile blue staining of tissue contaminants in murine leprosy bacilli preparation. (1960) (5)
- Diffuse neurofibrillary tangles with calcification in a non-demented woman. (1996) (5)
- Frequency and distribution of TUNEL‐positive neurons in brains of dementia with Lewy bodies: Comparison with those in brains of Alzheimer's disease (2001) (4)
- [Acquired pendular nystagmus after pontine hemorrhage]. (1999) (4)
- Evaluation of Probable or Possible Dementia with Lewy Bodies Using 123 I-IMP Brain Perfusion SPECT, 123 I-MIBG, and 99m Tc-MIBI (2007) (4)
- Light and electron microscopic examination of amyloid-rich primitive plaques: comparison with diffuse plaques (1990) (4)
- [Pick's disease with concomitant traumatic brain damage--five autopsied cases and a critical review of literatures (author's transl)]. (1980) (4)
- Increased incidence of dementia with Lewy bodies in patients carrying the ɛ4‐allele of apolipoprotein E (2004) (4)
- Long-Term Efficacy and Safety of Zonisamide for Treatment of Parkinsonism in Patients With Dementia With Lewy Bodies: An Open-Label Extension of a Phase three Randomized Controlled Trial. (2021) (4)
- [A clinicopathological study of Pick's disease--our sixty autopsied cases (author's transl)]. (1982) (4)
- An immunohistochemical study of beta-protein in Alzheimer-type dementia brains. (1989) (4)
- A novel mutation found in an adrenoleukodystrophy patient who underwent bone marrow transplantation (1998) (4)
- Peculiar axonal debris with subsequent astrocytic response (foamy spheroid body) (1992) (4)
- [Natural killer cell activity among patients with atopic dermatitis]. (2003) (4)
- Morphological characteristics of senile plaques in familial Alzheimer's disease (2004) (4)
- [A Japanese family with familial Alzheimer's disease associated with presenilin 1 mutation: relationship between younger age of onset and ApoE gene polymorphism]. (2003) (4)
- THE SELECTION OF TEST MATERIALS AND THE REVISION OF THE COLLECTION'S METHOD OF MURINE LEPROSY BACILLUS FOR ITS METABOLIC INVESTIGATIONS: For Basic Studies on Cultivation of the Human and Murine Leprosy Bacilli (1)@@@癩菌,鼠癩菌の培養に関連した基礎的研究(1) (1961) (4)
- Detection of Neurofibrillary Tangles by the Methenamine‐Silver Method: Comparison with Other Silver Stains and with Immunostaining Methods (1993) (3)
- An autopsied case of corticobasal degeneration showing severe cerebral atrophy over a protracted disease course of 16 years (2015) (3)
- Immunohistochemical investigation of human leukocyte antigen (HLA)-DR-positive astrocytes in adrenoleukodystrophy brain (1996) (3)
- Accumulation of human alpha-synuclein in different cytoskeletons in Lewy bodies in brains of dementia with Lewy bodies. (2000) (3)
- Intraneuronal Polyglucosan Bodies and Peculiar Inclusions in the Midbrain‐Tegmentum of the Aged (1987) (3)
- Degeneration of Pick bodies visualized by methenamine‐silver staining and immunohistochemistry (2002) (3)
- [Non-Alzheimer degenerative dementias]. (1999) (3)
- Striatonigral degeneration combined with Alzheimer's disease (2004) (3)
- [Method of isolation of rat leprosy bacteria]. (1961) (3)
- When does cerebral β‐amyloid deposition begin in Lewy body dementia? (2020) (3)
- New point mutation (R301X) of the α‐galactosidase a gene causing fabry disease (1995) (3)
- Response to ‘Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease)’ (2017) (3)
- [A comparative study of Alzheimer's disease and Pick's disease by CT]. (1984) (2)
- System degeneration of the thalamus (2004) (2)
- A new restriction-site polymorphism in the human proteolipid protein gene. (2008) (2)
- A new missense mutation in exon 6 of the proteolipid protein gene in a patient with Pelizaeus‐Merzbacher disease (1997) (2)
- [Amyotrophic lateral sclerosis with degeneration of thalamus and substantia nigra (author's transl)]. (1978) (2)
- [Dementia with Lewy bodies--from its finding to the present, including the CDLB guideline-revised]. (2007) (2)
- TAU-IMMUNOHISTOCHEMICAL AND -IMMUNOELECTRON MICROSCOPICAL INVESTIGATION OF ASTROCYTIC PLAQUES IN PROGRESSIVE SUPRANUCLEAR PALSY (1997) (2)
- [Hippocampal pathology in diffuse Lewy body disease]. (1998) (2)
- An Autopsied Case of Dentatorubropallidoluysian Atrophy with Atypical Pathological Features (1992) (2)
- Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease. (2001) (2)
- Neuropathological investigation of the hypometabolic regions on positron emission tomography with ( 18 F) fluorodeoxyglucose in patients with dementia (2012) (2)
- Pick's Disease and Head Trauma (1982) (2)
- Dementia with Lewy bodies (1996) (2)
- Familial presenile dementia with CJD-like lesions: preliminary results. (1985) (1)
- Biochemical Studies on Murine Leprosy Bacilli. I. Collection of Bacilli from Infected Tissue. (1958) (1)
- A neuropathologic study of long‐term, Economo‐type postencephalitic parkinsonism with a prolonged clinical course (1996) (1)
- 15 Diffuse Lewy body disease and diffuse neurofibrillary tangles with calcification (1996) (1)
- [An autopsied case of presenile dementia with tangles]. (2001) (1)
- Neuropathology of Dementia with Lewy Bodies (2002) (1)
- A computed tomography study of Alzheimer's disease by regional volumetric and parenchymal density measurements (1986) (1)
- [A case of complete rupture of the righ TMJ disc]. (1989) (1)
- Review of evidence and experience that might support changes of the classification of dementia and other disorders related to major brain damage (2011) (1)
- [Clouding of consciousness]. (2003) (1)
- Light and Electron Microscopic Observations of Diffuse Plaque and Its Related Conditions (1990) (1)
- [An autopsied case of subacute progressive dementia with flactuated disturbance of consciousness, myoclonus and periodic synchronous discharges on EEGs]. (1999) (1)
- History and Latest Concepts of Lewy Body Disease and Dementia with Lewy Bodies (2017) (1)
- Zonisamide improves DLB parkinsonism: A randomized double-blind placebo-controlled phase 3 study (2017) (1)
- [Clinical aspects of dementing illnesses in the elderly]. (2005) (1)
- Mval polymorphism in the proteolipid protein (PLP) gene (1995) (1)
- [Kosaka's disease]. (2008) (1)
- Zonisamide improves Parkinsonism in Dementia with Lewy Bodies (DLB): A randomized double-blind placebo-controlled Phase 3 study (2018) (0)
- P4-058: Proteome analysis of choroid plexus in Alzheimer's disease (2008) (0)
- STUDIES ON THE CHEMOTHERAPY OF LEPROSY: (XXI) ONSET SUPPRESSING ACTION OF ANTITUMOR AGENTS AND ANTIBACTERIALS IN MURINE LEPROSY@@@第21報 抗腫瘍性物質竝に二,三抗菌性物質 の鼠癩発症抑制作用 (1958) (0)
- 280 Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy (1996) (0)
- Combined Supranuclear Horizontal and Vertical Gaze Palsy in a Bilateral Thalamic Infarction (1999) (0)
- [Consideration on the origin of natural murine leprosy infection. Acid-fast bacillus present in the goldfish and inoculation of the bacilli into SPF mice reared under aseptic conditions using vinyl-isolator system (author's transl)]. (1973) (0)
- Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial (2015) (0)
- Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies (2015) (0)
- FROM THE PROPOSAL OF LEWY BODY DISEASE TO THE PROPOSAL OF DIFFUSE LEWY BODY DISEASE (2014) (0)
- The Effect of Cycloserine in Murine Leprosy. (1958) (0)
- Methenamine Silver Stain Impregnates Amyloid-related Components of Senile Plaques in the Alzheimer Brains as Clearly as βprotein Immunostaining (1990) (0)
- SORL1 JAD Wen Y et al Supple 2013 (2014) (0)
- [Changes in brain level of neurotransmitters in Alzheimer's disease]. (1988) (0)
- [Interdepartmental-rotation training of physicians in Japan--special reference to essentiality of psychiatry training]. (2000) (0)
- [Parkinsonism in Alzheimer's disease]. (1997) (0)
- 473 An autopsy case of atypical Alzheimer's disease with slowly progressive aphasia as initial symptom and clinical diagnosis of temporal type Pick's disease (1996) (0)
- 40th Annual Meeting of the Japanese Society of Neuropathology 3–5 June 1999 Pacifico Yokohama, JapanPresident: Kenji Kosaka (1999) (0)
- Endoscopic Findings of the Upper Digestive Tract in Patients with Liver Cirrhosis Showing Hepatofugal Flow in the Splenic Vein (1996) (0)
- STUDIES ON THE CULTIVATION OF HUMAN AND MURINE LEPROSY BACILLI IN TISSUE CULTURES: I. RELATION BETWEEN TEMPERATURE AND GROWTH OF L-CELLS AND TIME OF INOCULATION OF BACTERIA@@@第1報 L細胞の発育と温度の関係および鼠癩菌の播種時期について (1962) (0)
- Adjustment Disorders Among Patients with Atopic Dermatitis (2nd Report) : Psychiatric Intervention to Two Patients (2003) (0)
- Immuiiological Relationship between Leprosy and Murine Leprosy. I. Aniigenicity of Leprosy Bacillus and Murine Leprosy Bacillus in the Skin Reaction in Guinea Pigs. (1960) (0)
- THE RISK OF SECOND PRIMARY MALIGNANCIES IN PATIENTS WITH LUNG NEUROENDOCRINE TUMORS: A NESTED CASE‐CONTROL STUDY BASED ON SEER DATABASE (2019) (0)
- Dementia with Lewy Bodies and Parkinson Disease with Dementia Within the Spectrum of Lewy Body Disease (2010) (0)
- Differential expression of mRNAs detected by cDNA microarrays in Alzheimer's disease (2000) (0)
- [CT study in Alzheimer's disease]. (1983) (0)
- P3-179 Prostaglandin E2 synthesis is associated with Alzheimer’s disease pathology and is suggestive of pathogenic potency (2006) (0)
- Neuroleptic malignant syndrome and P450IID6 gene mutations (1999) (0)
- Influence on the Lepromin Reaction of Mouse Skin Tissue Components (1964) (0)
- Neuropathological Studies on Dementia with Lewy Bodies (2001) (0)
- First International Editorial Board Meeting for Neuropathology, September 1997, Perth, Australia (1998) (0)
- [Experimental studies on tuberculin allergy. IV. Relations between the state of allergy of the donors & the cellular passive transfer of tuberculin hypersensitivity]. (1958) (0)
- [Diffuse Lewy body disease]. (1999) (0)
- [An autopsied Japanese case of hereditary olivo-ponto-cerebellar atrophy compatible with the original one of Menzel's report (1891)]. (1993) (0)
- Behavioral and Psychological Symptoms of Dementia (2017) (0)
- [Dementia with Lewy bodies (DLB): general remarks]. (2011) (0)
- Neuropathological Findings in Severely Brain-Damaged Patients with Sleep Disorders (2007) (0)
- Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of Phase III trial (2015) (0)
- Zonisamide Improves Parkinsonism Without Psychiatric Deterioration in Patients with DLB: A Double-Blind Randomized Placebo-Controlled Study (2016) (0)
- Distribution of β-amyloid deposition and its clinical relevance in dementia with Lewy bodies: A pathological study (2010) (0)
- [On the combined cases with vascular dementia and senile dementia--analysis of the clincal findings of 8 cases (author's transl)]. (1976) (0)
- [Cortical dementia and subcortical dementia--comparison with Lewy body disease]. (1987) (0)
- ROLE OF SURGERY IN PATIENTS WITH EARLY STAGE SMALL‐CELL LUNG CANCER (2019) (0)
- A Clinicopathological Study of Idiopathic Normal Pressure Hydrocephalus (2002) (0)
- Progressive myoclonus epilepsy with unusual neuropathologic features (1995) (0)
- Studies on the Chemotherapy of Leprosy. XXIII. Onset suppressing Action of Ciba 1906, Griseofulvin, Zygomycin A and Several Drugs in Murine Leprosy. (1961) (0)
- P4-155 Apolipoprotein E 4 allele increases risk of dementia with Lewy bodies (2004) (0)
- Endoscopic Findings of the Upper Digestive Tract in Patients with Pancreatic Cancer (1995) (0)
- Brain Pathology of Dementias (2001) (0)
- [Profile of a nurse. Mr. Kazuo Kosaka active in the campaign to promote human rights of a psychiatric patient]. (1981) (0)
- [On the therapeutic approach to out-patients with organic dementia based on ageing processes of the brain (author's transl)]. (1976) (0)
- Changes of nucleus basalis of Meynert in the brain of Alzheimer type dementia (1987) (0)
- A novel deletion (c663delC) at exon 5 of the proteolipid protein gene in Pelizaeus‐Merzbacher disease (2001) (0)
- [Chronic neuropathologic change of experimental Wernicke's encephalopathy]. (1984) (0)
- 65-29 Clinical, SPECT and MRS findings of the patients with mitochondrial tRNALeu (UUR) mutation (1997) (0)
- Short Report on DNA Marker at Candidate Locus (1997) (0)
- SENSITIVITY OF WILD MICE TO MURINE LEPROSY (1959) (0)
- DIAGNOSTIC AND PROGNOSTIC IMPACT OF SERUM PROCALCITONIN IN NON‐SMALL CELL LUNG CANCER (2019) (0)
- SERIAL PASSAGE OF MURINE LEPROSY BACILLUS IN TESTICULAR TISSUE OF THE RAT AND MOUSE: FUNDAMENTAL STUDIES ON THE CULTIVATION OF HUMAN AND MURINE LEPROSY BACILLI (2)@@@癩菌,鼠癩菌の培養に関する基礎的研究(2) (1962) (0)
- [Diffuse Lewy body disease]. (1995) (0)
- Evaluation of probable/possible dementia with Lewy bodies (DLB) using 123I-IMP brain perfusion SPECT and 123I-MIBG myocardial SPECT (2007) (0)
- [Trends in study of Wernicke-Korsakoff syndrome]. (2007) (0)
- Analysis of Clinical and Neuroimaging Course of Four Patients with Left Side Dominant Fronto‐temporal Lobar Atrophy (2002) (0)
- Self-efficacy among Patients with Atopic Dermatitis (2004) (0)
- Numerous NFTS and loss of neurons in the substantia nigra of Alzheimer's disease (1992) (0)
- [Pathological dream states (twilight state, delirium, amentia, dreamy state, drunkenness)]. (2003) (0)
- Concering the Effectiveness of N. M. E. S. (Neuromuscular Electrical Stimulation) in the Treatment of Hemiplegic Shoulder Subluxation (1989) (0)
- [Amnestic syndrome]. (2003) (0)
- Mae III polymorphism in the NADH dehydrogenase subunit 4 gene. (1997) (0)
- [Suspected cases of familial Alzheimer's disease-a case report and a study on aneuploidy in leukocytes (author's transl)]. (1982) (0)
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What Schools Are Affiliated With Ken-ichi Kosaka?
Ken-ichi Kosaka is affiliated with the following schools:
