Kenneth Brinkhous

Kenneth Brinkhous's AcademicInfluence.com Rankings

Kenneth Brinkhous

Biology

#2311

World Rank

#3688

Historical Rank

#1039

USA Rank

Pathology

#29

World Rank

#71

Historical Rank

#15

USA Rank

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Biology

Kenneth Brinkhous's Degrees

Doctorate Medicine University of North Carolina at Chapel Hill

Why Is Kenneth Brinkhous Influential?

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According to Wikipedia, Kenneth Merle Brinkhous was a professor and chairperson in the Department of Pathology and Laboratory Medicine at the University of North Carolina at Chapel Hill. Brinkhous remained active in research until shortly before his death.

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Kenneth Brinkhous's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Effect of antihemophilic factor on one-stage clotting tests; a presumptive test for hemophilia and a simple one-stage antihemophilic factor assy procedure. (1953) (785)
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector (1999) (562)
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors (1999) (434)
Platelets fixed with paraformaldehyde: a new reagent for assay of von Willebrand factor and platelet aggregating factor. (1975) (314)
In vivo gene therapy of hemophilia B: sustained partial correction in factor IX-deficient dogs. (1993) (311)
THE INHIBITION OF BLOOD CLOTTING: AN UNIDENTIFIED SUBSTANCE WHICH ACTS IN CONJUNCTION WITH HEPARIN TO PREVENT THE CONVERSION OF PROTHROMBIN INTO THROMBIN (1939) (210)
Canine hemophilia B resulting from a point mutation with unusual consequences. (1989) (203)
A QUANTITATIVE STUDY ON BLOOD CLOTTING: PROTHROMBIN FLUCTUATIONS UNDER EXPERIMENTAL CONDITIONS (1936) (199)
Current Topics in Pathology (1974) (170)
Purified human factor VIII procoagulant protein: comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs. (1985) (164)
Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor. (1978) (154)
PROTHROMBIN DEFICIENCY AND THE BLEEDING TENDENCY IN LIVER INJURY (CHLOROFORM INTOXICATION) (1937) (141)
Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion. (1995) (119)
Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. (1989) (110)
Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs. (1996) (106)
Canine hemophilia; observations on the course, the clotting anomaly, and the effect of blood transfusions. (1949) (105)
Antihemophilic factor concentrate therapy in von Willebrand disease. Dissociation of bleeding-time factor and ristocetin-cofactor activities. (1976) (99)
A new high-potency glycine-precipitated antihemophilic factor (AHF) concentrate. Treatment of classical hemophilia and hemophilia with inhibitors. (1968) (96)
Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs. (1990) (93)
MILD HEMOPHILIA: AN ALLELIC FORM OF THE DISEASE° (1953) (92)
THE PARTIAL THROMBOPLASTIN TIME AS A SCREENING TEST FOR THE DETECTION OF LATENT BLEEDERS (1962) (84)
Newer approaches to the study of hemophilia and hemophilioid states. (1954) (84)
Prevention of occlusive coronary artery thrombosis by a murine monoclonal antibody to porcine von Willebrand factor. (1987) (83)
Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor (1989) (74)
Susceptibility to atherosclerosis in aortas and coronary arteries of swine with von Willebrand's disease. (1981) (74)
Clotting Defect in Hemophilia (1947) (73)
Assay of von Willebrand factor in von Willebrand's disease and hemophilia: use of a macroscopic platelet aggregation test. (1975) (71)
Morphologic manifestations of blood-solid interfacial reactions. A scanning and transmission electron microscopic study. (1969) (71)
Nature of von Willebrand factor: a new assay and a specific inhibitor. (1974) (67)
von Willebrand factor and occlusive arterial thrombosis. A study in normal and von Willebrand's disease pigs with diet-induced hypercholesterolemia and atherosclerosis. (1990) (67)
Botrocetin (venom coagglutinin): reaction with a broad spectrum of multimeric forms of factor VIII macromolecular complex. (1983) (64)
Bleeding Tendency of Obstructive Jaundice (1938) (62)
Macroscopic Studies of Platelet Agglutination; Nature of Thrombocyte Agglutinating Activity of Plasma.∗ (1958) (62)
Gene therapy and the hemophilias. (1994) (61)
A STUDY OF THE CLOTTING DEFECT IN HEMOPHILIA: THE DELATED FORMATION OF THROMBIN (1939) (61)
Venom coagglutinin for detection of von Willebrand factor activity in animal plasmas. (1983) (58)
Von Willebrand factor: gene dosage relationships and transfusion response in bleeder swine--a new bioassay. (1974) (57)
Recombinant human factor IX: replacement therapy, prophylaxis, and pharmacokinetics in canine hemophilia B. (1996) (56)
PLASMA THROMBOCYTE-AGGLUTINATING ACTIVITY AND FIBRINOGEN. SYNERGISM WITH ADENOSINE DIPHOSPHATE. (1965) (55)
Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor. (1989) (54)
Plasma aggregating factor (bovine) for human platelets: a marker for study of antihemophilic and von Willebrand Factors. (1973) (54)
CLINICAL USE OF A NEW GLYCINE‐PRECIPITATED ANTIHEMOPHILIC FRACTION (1965) (52)
Platelet adhesion to damaged coronary arteries: Comparison in normal and von Willebrand disease swine. (1982) (50)
Plasma levels of platelet aggregating factor/vom Willebrand factor in various species. (1977) (50)
Effect of Fibrinogen Concentration on Platelet Adhesion to Glass 1 (1971) (49)
Thrombotic thrombocytopenia with von Willebrand factor deficiency induced by botrocetin. An animal model. (1988) (48)
PROTHROMBIN DEFICIENCY THE CAUSE OF BLEEDING IN BILE FISTULA DOGS (1936) (48)
Efficient transfection of primary cells in a canine hemophilia B model using adenovirus-polylysine-DNA complexes. (1994) (47)
Hemophilia in the female dog. (1950) (46)
Preservation of platelet receptors for platelet aggregating factor/von Willebrand factor by air drying, freezing, or lyophilization: new stable platelet preparations for von Willebrand factor assays. (1978) (45)
Morphologic alterations of human blood platelets during early phases of clotting. Electron microscopic observations of thin sections. (1962) (45)
Comparison of inhibitory and binding characteristics of an antibody causing acquired von Willebrand syndrome: an assay for von Willebrand factor binding by antibody. (1985) (44)
Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation* (1964) (43)
Role of von Willebrand factor in arterial thrombosis. Studies in normal and von Willebrand disease pigs. (1991) (43)
STUDIES ON THROMBIN-INDUCED PLATELET AGGLUTINATION (1961) (42)
SOME PATHOGENETIC MECHANISMS OF WHITE THROMBUS FORMATION: AGGLUTINATION AND SELF-DESTRUCTION OF THE PLATELET. (1963) (40)
Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B. (1997) (39)
The roles of von Willebrand factor and factor VIII in arterial thrombosis: studies in canine von Willebrand disease and hemophilia A. (1993) (38)
Antibody nature of circulating inhibitor of plasma von Willebrand factor. (1975) (36)
Porcine von Willebrand disease and atherosclerosis. Influence of polymorphism in apolipoprotein B100 genotype. (1992) (36)
Histiocytic sarcoma with a granuloma-like component occurring in a large colony of Sprague-Dawley rats. (1981) (36)
PROTHROMBIN DEFICIENCY AND THE BLEEDING TENDENCY IN OBSTRUCTIVE JAUNDICE AND IN BILIARY FISTULA EFFECT OF FEEDING BILE AND ALFALFA (VITAMIN K) (1938) (36)
Antihemophilic Factor (AHF) Levels Following Transfusions of Blood, Plasma and Plasma Fractions.∗ (1955) (35)
Use of venom coagglutinin and lyophilized platelets in testing for platelet-aggregating von Willebrand factor. (1980) (35)
PLASMA PROTHROMBIN; VITAMIN K (1940) (35)
The roles of von Willebrand factor and factor VIII in arterial thrombosis: studies in canine von Willebrand disease and hemophilia A (1993) (35)
THE PURIFICATION OF THROMBIN (1938) (35)
Preclinical pharmacology of albumin-free B-domain deleted recombinant factor VIII. (2002) (34)
Hemorrhagic states secondary to intravascular clotting: an experimental study of their evolution and prevention. (1958) (33)
PLASMA PROTHROMBIN AND THE BLEEDING TENDENCY: WITH SPECIAL REFERENCE TO JAUNDICED PATIENTS AND VITAMIN K THERAPY (1939) (33)
The platelet: membrane and surface reactions. (1976) (32)
Further Experience With the Use of Thrombin as a Hemostatic Agent∗ (1939) (32)
Physiologic basis of transfusion therapy in hemophilia. (1956) (32)
Assay of Plasma Antihemophilic Activity in Normal, Heterozygous (Hemophilia) and Prothrombinopenic Dogs.∗ (1951) (32)
Fibrinogen--its role in platelet agglutination and agglutinate stability. A study of congenital aibrinogenemia. (1966) (32)
Utilization of the antihemophilic factor during clotting of canine blood and plasma. (1951) (31)
BLEEDING TENDENCY AND PROTHROMBIN DEFICIENCY IN BILIARY FISTULA DOGS: EFFECT OF FEEDING BILE AND VITAMIN K (1938) (31)
Extravascular Administration of Factor IX: Potential for Replacement Therapy of Canine and Human Hemophilia B (1997) (31)
Platelet agglutination and deagglutination with a sulfhydryl inhibitor, methyl mercuric nitrate: relationships to platelet ATPase. (1965) (31)
HEPARIN AND THE ANTITHROMBIC ACTIVITY OF PLASMA. (1942) (31)
Thrombogenicity of some biomedical materials: platelet-interface reactions. (1969) (30)
von Willebrand factor and animal models: contributions to gene therapy, thrombotic thrombocytopenic purpura, and coronary artery thrombosis. (1991) (30)
THE USE OF PURIFIED THROMBIN AS AN HEMOSTATIC AGENT. (1939) (30)
Von Willebrand syndrome induced by a Bothrops venom factor: bioassay for venom coagglutinin. (1981) (29)
Symposium: What Is Hemophilia?: Hemophilia and the Hemophilioid States (1954) (29)
Thrombotic thrombocytopenia induced in dogs and pigs. The role of plasma and platelet vWF in animal models of thrombotic thrombocytopenic purpura. (1995) (28)
Pharmacokinetics of Recombinant Factor IX after Intravenous and Subcutaneous Administration in Dogs and Cynomolgus Monkeys (2002) (28)
PLASMA PROTHROMBIN LEVELS IN VARIOUS VERTEBRATES (1939) (27)
The Prothrombin Conversion Rate in Various Species.∗ (1939) (27)
Muscular dystrophy in biliary fistula dogs; possible relationship to vitamin E deficiency. (1941) (25)
Fresh water drowning. Pulmonary ultrastructure and systemic fibrinolysis. (1974) (24)
Handbook of hemophilia (1975) (24)
PROTHROMBIN AND FIBRINOGEN IN LYMPH (1941) (24)
Expression and Linkage of Genes for X-linked Hemophilias A and B in the Dog (1973) (22)
Coronary atherosclerosis in the pig. Induced plaque injury and platelet response. (1990) (21)
RELATIVE STABILITY OF PLASMA ANTIHEMOPHILIC FACTOR (AHF) UNDER DIFFERENT CONDITIONS OF STORAGE* (1956) (21)
Effect of Vitamin K on Hypoprothrombinemia of Experimental Liver Injury.∗ (1940) (20)
PATHOPHYSIOLOGY OF PLATELET‐AGGREGATING von WILLEBRAND FACTOR: APPLICATIONS OF THE VENOM COAGGLUTININ vWF ASSAY * (1981) (20)
Gene transfer in the hemophilias: retrospect and prospect. (1992) (20)
Effect of blood platelets on prothrombin utilization of dog and human plasmas. (1949) (20)
Effect of carbon monoxide on atherogenesis in normal pigs and pigs with von Willebrand's disease. (1982) (19)
Prothrombin Utilization during Clotting (1950) (19)
Need of fibrinogen for thrombin-induced aggregation of porcine platelets. (1969) (19)
Specific Inhibition of Platelet Agglutination and Aggregation by Aromatic Amidino Compounds (1978) (19)
THE PURIFICATION OF PROTHROMBIN (1938) (18)
The Hemorrhagic Synchorne Complicating Extracorporeal Shunting of Blood: An Experimental Study of its Pathogenesis (1958) (18)
Macromolecular factor VIII complex: functional and structural heterogeneity observed in von Willebrand swine with transfusion. (1977) (17)
Survival of Transfused Factor VIII in Hemophilic Patients Treated with Epsilon Aminocaproic Acid (2003) (16)
MORPHOLOGICAL STUDY OF EARLY PHASES OF PLATELET ADHESION TO FOREIGN SURFACES: EFFECT OF CALCIUM a (1983) (15)
Factor VIII synthesis: hepatic and renal allografts in swine with von Willebrand's disease. (1976) (15)
Inventory of Exogenous Platelet-Aggregating Agents Derived from Venoms (1991) (13)
W. W. Duke and his bleeding time test. A commentary on platelet function. (1983) (13)
Plasma Antihemophilic Activity Following Total Body Irradiation.∗ † (1951) (12)
Plasma antihemophilic factor biological and clinical aspects. (1954) (12)
Blood clotting: the plasma procoagulants. (1959) (12)
LUNG EXTRACT AND BLOOD CLOTTING (1933) (11)
A Study of the Separation of Fibrinogen and Antihemophilic Factor (AHF) in Canine, Porcine, and Human Plasmas (1957) (11)
Species differences in platelet agglutination in man and in the dog, swine and rabbit. (1960) (11)
[12] Fixation platelets and platelet agglutination/aggregation tests (1989) (11)
HEMOPHILIA--PATHOPHYSIOLOGIC STUDIES AND THE EVOLUTION OF TRANSFUSION THERAPY. (1964) (11)
Expression and linkage of genes for X-linked hemophilias A and B in the dog. (1973) (11)
Scanning electron microscopy of synovial membranes. (1972) (11)
Thrombolysis and Thrombolytic Agents: A Brief Review (1961) (11)
The Association of American Physicians 1886-1986: A Century of Progress in Medical Science (1987) (11)
Fixation platelets and platelet agglutination/aggregation tests. (1989) (10)
Cure and Prevention of Vitamin E-Deficient Muscular Dystrophy with Synthetic α-Tocopherol Acetate (1939) (10)
Preclinical studies of recombinant factor IX. (1998) (10)
Glycine-precipitated antihemophilic factor concentrates and their clinical use. (1968) (9)
Hemostatic disorders: hemophilia and the hemophilioid diseases. (1958) (8)
Animal models: importance in research on hemorrhage and thrombosis. (1978) (8)
Evolution and decay of platelet-agglutinating activity in normal and pathologic human plasmas. (1962) (8)
INTENSIVE PLASMA THERAPY IN THE HEMOPHILIAS. (1964) (8)
Antihemophilic Factor (AHF) (1957) (8)
Summary of workshops 4a & 4b: animal models of atherosclerosis involving the thrombotic process. (1978) (7)
Physiopathology of hemophilia. (1958) (7)
Hemophilia and von Willebrand's disease. Some biological determinants. H. P. Smith memorial lecture. (1975) (7)
Cation Specificity of Thrombocyte Agglutinating Activity (TAg) of Canine Plasma.∗ (1959) (7)
Serum Accelerator Factors and Antihemophilic Factor (AHF) in Early Phases of Clotting.∗ (1954) (7)
HEPARIN AND BLOOD CLOTTING. (1939) (7)
Determinants of von Willebrand factor activity elicited by ristocetin and botrocetin: studies on a human von Willebrand factor-binding antibody. (1985) (6)
The effect of dextrose on chromatography of antihemophilic factor (Factor VIII) (1972) (6)
Antiaccelerator (Anticonvertin) Activity of Canine Plasma and Serum.∗ (1955) (6)
Hemophilia and the hemophilioid states. (1954) (5)
Platelets : their role in hemostasis and thrombosis : transactions of the conference held under the auspices of the International Committee on Haemostasis and Thrombosis, Chapel Hill, North Carolina, U.S.A., December 1966 (1967) (5)
The Year Book of Pathology and Clinical Pathology (1958‐1959 Year Book Series) (1960) (5)
Characterization of a new hereditary thrombopathy in a closed colony of Wistar rats. (1996) (5)
Effect of a new antiaggregating chemical on the structure and function of the human platelet. (1971) (5)
Laboratory Detection of Female Carriers of Canine Hemophilia (1964) (4)
Can Hemophilic Patients Be Adequately Maintained with Cryoprecipitates? Or Is it Desirable or Even Necessary to Manufacture and Administer Highly Concentrated AHF Products? (1972) (4)
Effect of Wheat Germ Oil Upon E-Deficient Muscular Dystrophy (1939) (4)
CANINE HEMOPHILIA AND MALE PSEUDOHERMAPHRODITISM; CYTOGENETIC STUDIES. (1963) (3)
Fibrinogen: requirement for platelet aggregation and adhesion. (1972) (3)
Glycoprotein Ib bioassays. Activity levels in Bernard-Soulier syndrome and in stored blood bank platelets. (1991) (3)
Quantitation of von Willebrand factor and an antibody inhibitor (1976) (3)
Human Antihemophilic Factor (AHF) Purification A Comparison of Two Procedures (1966) (3)
Review of the present status of other clotting factors: c) Factor VIII (AHF) (1959). (1961) (3)
Fibrinogen and platelet agglutination. (1967) (3)
Why Virchow became a physician. (1968) (2)
Some mechanisms of thrombus formation and hemorrhage following trauma. (1969) (2)
Clotting defect in hemophilia; deficiency in a plasma factor required for thromboplastin liberation from platelets. (1947) (2)
Hemophilia-like disease of swine: cytogenetic studies. (1968) (2)
Induced Coronary and Aortic Atherosclerosis in Swine with Von Willebrand’s Disease (1979) (2)
Blood coagulation and hemophilioid disorders. (1968) (2)
Effect of surface activated clot promoting material on the assay of antihemophilic factor (AHF). (1960) (1)
Paul M. Aggeler (1969) (1)
Survey of American pathologists. An analysis of sources and training of research pathologists. (1965) (1)
Harry P. Smith (1895-1972). Pathologist, teacher, investigator, administrator. (1975) (1)
Vascular factors and thrombosis : transactions of the conference held under the auspices of the International Committee on Haemostasis and Thrombosis, Bath, England, October 1969 (1970) (1)
Hemophilia and new hemorrhagic states;: International symposium, New York (1970) (1)
Report of the subcommittee on human factor VIII and factor IX preparations. (1968) (1)
Changing prospects for children with hemophilia. (1970) (1)
Thrombin and its clinical applications. (1947) (1)
Current Status of Plasma Fraction Therapy in Hemophilia A (1972) (1)
EXPANDING CAREER OPPORTUNITIES FOR PATHOLOGISTS TRAINED IN RESEARCH. (1964) (1)
Christmas Disease (1953) (1)
XXII Annual Meeting of the International Committee on Thrombosis and Haemostasis (1977) (1)
Use of aliphatic amino acid precipitated antihemophilic factor in therapy of hemophilia. (1968) (1)
Development and present status of concentrate therapy for hemophilia and von Willebrand's disease. (1982) (1)
Use of the computer in inventory control in the blood bank. (1968) (1)
Extravascular administration of factor IX: potential for replacement therapy of canine and human hemophilia B. (1997) (1)
Current Topics in Pathology / Ergebnisse der Pathologie (1970) (1)
Venom Coagglutinin and Lyophilized Platelets for Assay of Plasma Von Willebrand Factor: Comparison With Ristocetin (1979) (1)
IN MEMORIAM: JAMES BELL BULLITT, 1874-1964. (1965) (1)
EPILOGUE—HEMOPHILIA IN 1974: THEORY AND PRACTICE (1975) (1)
Research training in pathology. (1954) (1)
The Detection of Hemophilic Carriers1 Introductory Remarks (1966) (0)
Panel Discussion (1964) (0)
DDAVP: DOES TEE DRUG RAVE A DIRECT EFFECT ON TEE VESSEL WALL? (1983) (0)
Plasmatic clotting and/or blood cellular clumping in clinical conditions, experimental animals, and in perfused organs. (1976) (0)
Lpb Genotype and Increase in Serum Cholesterol Levels in 19 Normal Swine Fed an Atherogenic Diet (2007) (0)
The detection of hemophilic carriers. Introductory remarks. (1966) (0)
Perpectives of fibrinolysis and thrombolysis. (1961) (0)
PREVENTION OF OCCLUSIVE CORONARY THROMBOSIS BY MONOCLONAL ANTIBCDY TO VON WILLEBRAND FACTOR IN SWINE (1987) (0)
Hemophilia and other hemorrhagic states : international symposium, Rome (1959) (0)
Thrombosis : Pathogenesis and Clini cal Trials (2007) (0)
Treatment for Hemophilia: Gene Therapy vs Transplantation-Reply (1994) (0)
Editorial (1971) (0)
NatureofvonWillebrand Factor: A NewAssayandaSpecific Inhibitor (1974) (0)
Book ReviewHemostasis and Thrombosis: Basic principles and clinical practice Haemostasis and Thrombosis (1988) (0)
Christmas disease. (1953) (0)
D. Murray Angevine, chief editor. (1973) (0)
An overview: hemophilia and hemostasis. (1981) (0)
Basic mechanisms of cell adhesion and platelet thrombus formation. Introductory remarks. (1967) (0)
Fibrinogen : structural, metabolic and pathophysiologic aspects : transactions of the conference held under the auspices of the International Committee on Haemostasis and Thrombosis, Princeton, New Jersey, U.S.A., November 24-26, 1968 (1970) (0)
Presentation of the gold headed cane to Emory D. Warner, April 16, 1980. (1980) (0)
INTERNATIONAL SYMPOSIUM ON HEMOPHILIA AND HEMOPHILIOID DISEASES (1958) (0)
Shirley A. Johnson (1922-1970). (1971) (0)
William W. McLendon, MD. The sixth editor of the Archives of Pathology and Laboratory Medicine. (1984) (0)
Walter H. Seegers, 1910-1996 (1996) (0)
Editorial: The Archives of Pathology and Laboratory Medicine. (1976) (0)
Willebrand Factor in Arterial Thrombosis (2005) (0)
The hemorrhagic diseases. (1963) (0)
CANINE HEMOPHILIA (1949) (0)
Recent Advances in Blood Coagulation (1977) (0)
Judith Graham Pool, Ph. D. (1919–1975) An Appreciation (1976) (0)
Advances and controversies in blood coagulation: a 50‐year retrospective (1992) (0)
TREATMENT FOR HEMOPHILIA : GENE THERAPY VS TRANSPLANTATION. AUTHORS' REPLY (1994) (0)
Armand J. Quick, 1894-1978. (1979) (0)
Armand J. Quick, Ph.D., M.D. 1894-1978 (1979) (0)
Obituary--Paul M. Aggeler. (1969) (0)
Selective Inhibition of Platelet Agglutination and Aggregation by Aromatic Amidino Compounds (1977) (0)
Peripheral Vascular Disease: Comparative Ultrastructure Of Veins, Valves And Arteries (1981) (0)
Reginald Gladstone Mason, JR., M.D., Ph.D., (1933–1981) (1982) (0)
Benjamin Alexander, M.D. 1909-1978 (1979) (0)

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