Kenneth Kaushansky

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Kenneth Kaushansky

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Kenneth Kaushansky

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Why Is Kenneth Kaushansky Influential?

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According to Wikipedia, Kenneth Kaushansky, M.D., Master of the American College of Physicians is an American medical doctor, hematologist, former editor of the medical journal Blood, and served as the dean of the Stony Brook University School of Medicine from 2010 to 2021. Prior to moving to Stony Brook, he was the Helen M. Ranney Professor, and chair of the department of medicine at University of California, San Diego School of Medicine.

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Kenneth Kaushansky's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 Kip1 -Deficient Mice (1996) (1610)
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function (2000) (1236)
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo (1994) (1114)
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin (1994) (1045)
The molecular mechanisms that control thrombopoiesis. (2005) (513)
Thrombopoietin the primary regulator of platelet production. (1995) (452)
Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. (1995) (416)
The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. (1996) (357)
Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor. (1986) (340)
Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. (1995) (324)
Lineage-specific hematopoietic growth factors. (2006) (295)
Historical review: megakaryopoiesis and thrombopoiesis. (2008) (288)
Thrombopoietin The Primary Regulator of Platelet Production (1997) (285)
Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. (1996) (274)
Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. (1995) (247)
Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions. (1989) (245)
The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl (*) (1995) (241)
Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. (1988) (235)
Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. (1987) (234)
Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. (1999) (223)
Thrombopoietin signal transduction in purified murine megakaryocytes. (1997) (200)
Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha. (1991) (199)
The Common γ Chain (γc) Is a Required Signaling Component of the IL-21 Receptor and Supports IL-21-Induced Cell Proliferation via JAK3† (2002) (197)
Murine thrombopoietin mRNA levels are modulated by platelet count. (1995) (197)
The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production (2002) (195)
Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. (1996) (192)
Mechanisms of cytomegalovirus-mediated myelosuppression: perturbation of stromal cell function versus direct infection of myeloid cells. (1990) (191)
A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. (1991) (182)
Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. (1996) (170)
Thrombopoietin expands hematopoietic stem cells after transplantation. (2002) (168)
The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. (1995) (168)
Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. (1997) (164)
Thrombopoietin from beginning to end (2014) (161)
Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. (1986) (152)
Human platelets display high-affinity receptors for thrombopoietin. (1997) (143)
Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. (2000) (142)
Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK). (2000) (140)
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. (2015) (139)
Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC). (1988) (133)
Thrombopoietin Signal Transduction Requires Functional JAK2, Not TYK2* (1999) (129)
Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities. (2006) (129)
Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet Production (1995) (129)
IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses. (2003) (124)
Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells. (2003) (124)
Thrombopoietin Induces Phosphoinositol 3-Kinase Activation through SHP2, Gab, and Insulin Receptor Substrate Proteins in BAF3 Cells and Primary Murine Megakaryocytes* (2001) (121)
Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. (2008) (121)
Determinants of platelet number and regulation of thrombopoiesis. (2009) (117)
Obesity-driven disruption of haematopoiesis and the bone marrow niche (2014) (110)
The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. (2002) (110)
Secretable human platelet-derived factor V originates from the plasma pool. (1998) (108)
Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha. (2004) (108)
Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy. (1996) (107)
Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha. (2001) (96)
Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo. (1988) (94)
Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release. (1989) (93)
Thrombopoietin: a pan-hematopoietic cytokine. (2002) (90)
Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. (1995) (90)
Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice. (1996) (88)
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. (2008) (87)
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl. (2010) (86)
Endomitotic Megakaryocytes that Form a Bipolar Spindle Exhibit Cleavage Furrow Ingression Followed by Furrow Regression (2007) (85)
Thrombopoietin and the Hematopoietic Stem Cell (2005) (84)
Targeted expansion of genetically modified bone marrow cells. (1998) (82)
Phosphatidylinositol 3-Kinase Is Necessary but Not Sufficient for Thrombopoietin-induced Proliferation in Engineered Mpl-bearing Cell Lines as Well as in Primary Megakaryocytic Progenitors* (2001) (81)
Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factors. (1989) (81)
Transcriptional regulation of interleukin 3 gene expression in T lymphocytes. (1990) (79)
Thrombopoietin: a tool for understanding thrombopoiesis (2003) (79)
Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro (1991) (79)
JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms (2014) (78)
Effect of thrombopoietin on the development of megakaryocytes and platelets: an ultrastructural analysis. (1996) (77)
Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression. (2008) (77)
Thrombopoietin Induces HOXA9 Nuclear Transport in Immature Hematopoietic Cells: Potential Mechanism by Which the Hormone Favorably Affects Hematopoietic Stem Cells (2004) (77)
On the molecular origins of the chronic myeloproliferative disorders: it all makes sense. (2005) (75)
YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. (2007) (75)
Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding. (1999) (73)
Differential Expression of M‐CSF, G‐CSF, and GM‐CSF by Human Monocytes (1990) (71)
On the molecular origins of the chronic myeloproliferative disorders: it all makes sense. (2005) (70)
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. (2006) (70)
Role of carbohydrate in the function of human granulocyte-macrophage colony-stimulating factor. (1987) (67)
The role of protein kinase C in the induction of VCAM‐1 expression on human umbilical vein endothelial cells (1993) (67)
The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm. (2014) (67)
Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production (2004) (60)
Hematopoietic growth factors: understanding functional diversity in structural terms. (1993) (60)
Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. (1989) (60)
Thrombopoietin and the hematopoietic stem cell. (1998) (58)
Megakaryocytes express functional Aurora-B kinase in endomitosis. (2004) (58)
Hematopoietic colony-stimulating factors. (1991) (54)
Endomitotic Megakaryocytes form a Midzone in Anaphase but Have a Deficiency in Cleavage Furrow Formation (2006) (53)
Control of granulocyte-macrophage colony-stimulating factor production in normal endothelial cells by positive and negative regulatory elements. (1989) (53)
JAK2, complemented by a second signal from c‐kit or flt‐3, triggers extensive self‐renewal of primary multipotential hemopoietic cells (2002) (52)
Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice. (1996) (52)
Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. (2011) (52)
Mechanisms of tumor-induced neutrophilia: constitutive production of colony-stimulating factors and their synergistic actions. (1989) (51)
PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27Kip1 (2008) (50)
Molecular mechanisms of thrombopoietin signaling (2009) (50)
Thrombopoietin (TPO) regulates HIF-1α levels through generation of mitochondrial reactive oxygen species (2008) (50)
Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor. (2000) (49)
Megakaryocytes require thrombospondin-2 for normal platelet formation and function. (2003) (48)
Tumor necrosis factor type a stimulates human endothelial cells to produce granulocyte / macrophage colony-stimulating factor (48)
The enigmatic megakaryocyte gradually reveals its secrets. (1999) (48)
Thrombopoietin signal transduction: studies from cell lines and primary cells. (1999) (46)
Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides. (1994) (45)
Two neutralizing monoclonal antibodies against human granulocyte-macrophage colony-stimulating factor recognize the receptor binding domain of the molecule. (1990) (44)
The glycan domain of thrombopoietin enhances its secretion. (2000) (42)
Thrombopoietin: understanding and manipulating platelet production. (1997) (41)
Engagement of integrin α4β1 enhances thrombopoietin-induced megakaryopoiesis (2005) (41)
Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro (1997) (41)
Thrombopoietin, the c‐mpl ligand, is a major regulator of platelet production (1995) (41)
The thrombocytopenia of cancer. Prospects for effective cytokine therapy. (1996) (40)
Thrombopoietin and Hematopoietic Stem Cell Development (1999) (40)
JAK2V617F-mutant megakaryocytes contribute to hematopoietic stem/progenitor cell expansion in a model of murine myeloproliferation (2016) (40)
Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit. (1996) (39)
Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell. (2003) (39)
A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies (2008) (38)
The Root of Platelet Production (2007) (37)
The mpl ligand: molecular and cellular biology of the critical regulator of megakaryocyte development. (1994) (37)
In vitro characterization of the human recombinant soluble granulocyte-macrophage colony-stimulating factor receptor. (1995) (37)
Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes. Role of AP-1- and octamer-binding proteins in control of IL3 gene expression. (1993) (36)
Transcriptional regulation of megakaryopoiesis: thrombopoietin signaling and nuclear factors (2006) (36)
Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes. (2006) (36)
The Roles of Phosphatidylinositol 3-Kinase and Protein Kinase Cζ for Thrombopoietin-induced Mitogen-activated Protein Kinase Activation in Primary Murine Megakaryocytes* (2001) (36)
Kinetics of endomitosis in primary murine megakaryocytes (2001) (35)
The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms (2017) (34)
In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients (1991) (34)
Interleukin‐4 induces endothelial vascular cell adhesion molecule‐1 (VCAM‐1) by an NF‐κb‐independent mechanism (1995) (34)
Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody. (1996) (32)
Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3. (1992) (31)
Response of simian virus 40 (SV40)-transformed, cultured human marrow stromal cells to hematopoietic growth factors. (1989) (30)
PI3K/Akt/FOXO3a Pathway Contributes to Thrombopoietin-Induced Proliferation of Primary Megakaryocytes In Vitro and In Vivo Via Modulation of p27 Kip1 . (2005) (29)
Thrombopoietin: More than a lineage‐specific megakaryocyte growth factor (1997) (28)
In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients. (1991) (28)
D-Dimer-Driven Anticoagulation Reduces Mortality in Intubated COVID-19 Patients: A Cohort Study With a Propensity-Matched Analysis (2021) (27)
JAK2V617F-mutant vascular niche contributes to JAK2V617F clonal expansion in myeloproliferative neoplasms. (2016) (27)
Thrombopoietin and its receptor in normal and neoplastic hematopoiesis (2016) (26)
Structure and function of the cytokine receptor superfamily (1995) (25)
Chronic destructive arthritis in familial Mediterranean fever: the predominance of hip involvement and its management. (1981) (25)
Engagement of integrin alpha4beta1 enhances thrombopoietin-induced megakaryopoiesis. (2005) (25)
JAK2V617F-bearing vascular niche enhances malignant hematopoietic regeneration following radiation injury (2018) (25)
The chronic myeloproliferative disorders and mutation of JAK2: Dameshek's 54 year old speculation comes of age. (2007) (25)
The American Society of Hematology: a success at age 50. (2008) (24)
Selective Inhibition of JAK2 Driven Erythroid Differentiation of Polycythemia Vera Progenitors (2007) (24)
Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling (2011) (24)
Interleukin-1 alpha also induces granulocyte-macrophage colony-stimulating factor in immature normal bone marrow cells. (1990) (24)
A Structure-Function Analysis of Serine/Threonine Phosphorylation of the Thrombopoietin Receptor, c-Mpl* (2000) (24)
Transcriptional regulation of bone marrow thrombopoietin by platelet proteins. (2008) (24)
Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice. (2002) (23)
JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling (2018) (23)
The Mpl receptor expressed on endothelial cells does not contribute significantly to the regulation of circulating thrombopoietin levels. (2006) (22)
Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies. (1991) (21)
Identification of functionally distinct domains of human granulocyte- macrophage colony-stimulating factor using monoclonal antibodies (1991) (21)
Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway. (2008) (21)
Studies with Chimeric Mpl/JAK2 Receptors Indicate That Both JAK2 and the Membrane-proximal Domain of Mpl Are Required for Cellular Proliferation* (2002) (21)
Interleukin-6 is not involved in the interleukin-1-induced production of colony-stimulating factors by human bone marrow stromal cells and fibroblasts. (1989) (21)
Hem-1, a potential membrane protein, with expression restricted to blood cells. (1991) (21)
Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency. (2003) (20)
Williams manual of hematology (2011) (20)
Use of thrombopoietic growth factors in acute leukemia (2000) (20)
Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells. (1992) (19)
Immunology. The root of platelet production. (2007) (18)
The regulation of normal and neoplastic hematopoiesis is dependent on microenvironmental cells. (2018) (18)
Thrombopoietin Stimulates Vascular Endothelial Cell Growth factor (VEGF) Production in Hematopoietic Stem Cells (2005) (18)
Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor. (1990) (17)
Recombinant Antibodies in Bioactive Peptide Design (*) (1995) (17)
Hematopoietic Growth Factor Mimetics (2001) (17)
The molecular biology of the colony-stimulating factors. (1987) (16)
Thrombopoietin: from theory to reality (1999) (16)
Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. (2014) (16)
Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders. (2006) (16)
Biology of thrombopoietin. (1998) (15)
The regulation of GM-CSF is dependent on a complex interplay of multiple nuclear proteins. (1996) (15)
The role of lymphocytes and monocytes in hematopoietic growth factor production by peripheral blood mononuclear cells. (1989) (15)
Thrombopoietin from human embryonic kidney cells is the same factor as c-mpl-ligand. (1995) (15)
Geospatial Distribution and Predictors of Mortality in Hospitalized Patients With COVID-19: A Cohort Study (2020) (15)
Thrombopoietin: basic biology, clinical promise. (1995) (14)
Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm (2019) (14)
Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions. (1989) (14)
Molecular modeling of human granulocyte-macrophage colony-stimulating factor. (1990) (13)
Blood: new designs for a new millennium. (2000) (13)
CDP/Cut DNA binding activity is down-modulated in granulocytes, macrophages and erythrocytes but remains elevated in differentiating megakaryocytes (2000) (12)
Structure–function relationships of the hematopoietic growth factors (1992) (12)
Megakaryocytic differentiation of HIMeg-1 cells induced by interferon gamma and tumour necrosis factor alpha but not by thrombopoietin. (1998) (12)
Comprar Williams Hematology 8th Ed + DVD | Ernest Beutler | 9780071621519 | Mcgraw-Hill Education (2010) (12)
Granulocyte-macrophage colony-stimulating factor expression is regulated at transcriptional and posttranscriptional levels in a murine bone marrow stromal cell line. (1994) (11)
Thrombopoietin: Platelets on Demand (1997) (11)
The Glycan Domain of Thrombopoietin (TPO) Acts intrans to Enhance Secretion of the Hormone and Other Cytokines* (2002) (11)
Etiology of the myeloproliferative disorders: the role of thrombopoietin. (2003) (10)
Thrombopoietin stimulates Hoxb 4 expression : an explanation for the favorable effects of TPO on hematopoietic stem cells (2003) (10)
Systems biology of megakaryocytes. (2014) (9)
Thrombopoietin: biological and preclinical properties. (1996) (9)
Mapping of human granulocyte-macrophage-colony-stimulating-factor domains interacting with the human granulocyte-macrophage-colony-stimulating-factor-receptor alpha-subunit. (1994) (9)
Williams Hematology (9th Ed.) (2016) (9)
Small molecule mimics of hematopoietic growth factors: improving on Mother Nature? (2001) (9)
A Novel Activating JAK2 Mutation, JAK2R564Q, Causes Familial Essential Thrombocytosis (fET) Via Mechanisms Distinct From JAK2V617F (2011) (8)
Removing the cloud from industry-sponsored, multicentered clinical trials. (2001) (8)
Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical vein endothelial cells. (1993) (8)
Mpl and the hematopoietic stem cell (2002) (8)
The role of the MPL receptor in myeloproliferative disorders. (1998) (7)
Mercury and Thyroid Autoantibodies in U.S. Women, NHANES 2007-2008 (2012) (7)
Evolving insights into the synergy between erythropoietin and thrombopoietin and the bipotent erythroid/megakaryocytic progenitor cell. (2016) (6)
Thrombopoietin in normal and neoplastic stem cell development. (2009) (5)
Do the Preclinical Effects of Thrombopoietin Correlate with Its In Vitro Properties? (1996) (5)
Thrombopoietin: In vitro predictions, in vivo realities (1996) (5)
Physiology and preclinical studies of thrombopoietin (1995) (5)
An Evolving Clinical Need: Discordant Oxygenation Measurements of Intubated COVID-19 Patients (2021) (5)
Thrombopoietin: basic biology and clinical promise. (1997) (5)
The marrow stem cell niche in normal and malignant hematopoiesis (2020) (4)
Thrombopoietin and the physiology of platelet production. (1996) (4)
Thrombopoietin promotes beta1-integrin-mediated adhesion in hematopoietic cells via the small GTPase Rapl. (2007) (4)
ASCI Presidential Address: Mentoring and teaching clinical investigation. (2004) (4)
Functional interdependence of hematopoietic stem cells and their niche in oncogene promotion of myeloproliferative neoplasms: the 159th biomedical version of "it takes two to tango". (2019) (4)
Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin. (2000) (4)
A New Feature: Controversies in Hematology (1998) (4)
Glossary of molecular biology terminology. (1996) (4)
Blood's 70th anniversary: the elusive von Willebrand factor-cleaving protease. (2016) (4)
A neutralizing monoclonal antibody binds to an epitope near the amino terminus of murine granulocyte-macrophage colony-stimulating factor. (1991) (4)
Thrombocytosis in an infant with high thrombopoietin concentrations. (2004) (4)
The imperative to invest in science has never been greater. (2014) (4)
Molecular biology glossary. (1994) (3)
Inhibition of JAK2 V617F-Induced Erythroid Skewing of Hematopoietic Stem Cell Differentiation with a Selective JAK2 Antagonist. (2006) (3)
The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche). (2020) (3)
Physician-Scientists: Preparation, Opportunities, and National Need (2003) (3)
Thrombopoietin: From Theory to Reality (1999) (3)
Identification and characterization of an isoform of murine Mpl. (2002) (3)
Thrombopoietin promotes β1-integrin–mediated adhesion in hematopoietic cells via the small GTPase Rap1 (2007) (3)
The C-Mpl Receptor Expressed on Endothelial Cells Does Not Contribute Significantly to the Regulation of Circulating Thrombopoietin (TPO) Levels. (2004) (3)
Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche (2022) (3)
Multiple myeloma: multiple ways to defeat erythropoiesis (2001) (3)
High Concentrations of Thrombopoietin Activate Platelets In Vitro (1998) (3)
Thrombopoietin: Basic Biology and Clinical Effects (2000) (2)
Hunting for hematopoietic transcriptional networks (2018) (2)
THROMBOPOIETIN: DOES THE IN VITRO BIOLOGY CORRELATE WITH ITS IN VIVO PROPERTIES? (1996) (2)
159 – Hematopoiesis and Hematopoietic Growth Factors (2012) (2)
JAK2V617F mutant megakaryocytes contribute to hematopoietic aging in a murine model of myeloproliferative neoplasm (2021) (2)
Polychlorinated Biphenyls: In situ Bioremediation from the Environment (2011) (2)
The vWF-cleaving protease: new opportunities in TTP (2001) (2)
[Interferon-alpha directly inhibits thrombopoietin-induced megakaryocyte proliferation and differentiation]. (2001) (2)
Megakaryocytes their precursors and their progeny. (1996) (2)
Bloodlines: the importance of mentoring for the future of hematology. (2007) (2)
JAK2V617F mutant endothelial cells promote neoplastic hematopoiesis in a mixed vascular microenvironment. (2021) (2)
Glossary of Molecular Biology Terminology. (2000) (1)
Cell expansion and maintenance of stemness. (2008) (1)
Thrombopoietin (2003) (1)
JAK2V617F-Mutant Vascular Niche Promotes JAK2V617F Clonal Expansion in Myeloproliferative Neoplasms (2016) (1)
Selective Inhibition of JAK2-Driven Erythroid Differentiation of Polycythemia Vera Progenitors (DOI: 10.1016/j.ccr.2008.02.017) (2008) (1)
Interferon-α directly inhibits thrombopoietin-induced megakaryocyte proliferation and differentiation (2001) (1)
Aurora-B Kinase Translocates to the Midzone in Endomitotic Megakaryocytes. (2004) (1)
Inhibition of GSK-3 β promotes survival and proliferation of megakaryocytic cells through a β -catenin-independent pathway (2009) (1)
Cell competition between wild-type and JAK2V617F mutant cells in a murine model of a myeloproliferative neoplasm. (2021) (1)
Thrombopoietin-Mediated Ubiquitination and Degradation of C-Mpl (2008) (1)
How I treat": a new style of clinical review article (2000) (1)
Thrombopoietin Promotes b1 Integrin-Mediated Adhesion in Hematopoietic Cells Via the Small GTPase Rap1. (2006) (1)
Application for Fellowship (2012) (1)
Thrombopoietin and platelet development. (1996) (1)
Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis Thrombopoietin-Induced Activation of the Mitogen-Activated Protein (2013) (1)
The Hematopoietic Colony-Stimulating Factors (2021) (0)
Tribute to Donald Metcalf. (2015) (0)
The Centre for Blood Research presents The Earl W. Davie Symposium (2015) (0)
Hematopoietic growth factors: The structural basis of functional diversity (1995) (0)
Access to the biomedical literature: a stand against coercion. (2001) (0)
α megakaryocytes: the role of protein kinase C Actin reorganization and proplatelet formation in murine (2013) (0)
Summer Public Health Scholars Program (2012) (0)
Stony Brook University Hospital Medical Staff (2009) (0)
Celebrate hematology. (2002) (0)
Policy : Program Curriculum Review. (2009) (0)
THE HEPARIN WOES : CONTAMINATION , CONTACT ACTIVATION , REGULATION , AND LEGISLATION (0)
Immune thrombocytopenic purpura (2010) (0)
Thrombocytosis in an infant with high thrombopoietin levels (2003) (0)
Factors Affecting Thrombopoietin Production from Bone Marrow Stromal Cells. (2004) (0)
factor as c-mpl-ligand (letter) Thrombopoietin from human embryonic kidney cells is the same (2011) (0)
enhances thrombopoietin-induced megakaryopoiesis (2005) (0)
Patient Request for Amendment of Protected Health Information (PHI) (2009) (0)
Thrombopoietin (TPO) Regulates HIF-1α Level through Generation of Mitochondrial Reactive Oxygen Species (ROS). (2005) (0)
Defining units for thrombopoietin. (1995) (0)
GUEST EDITORIAL THROMBOPOIETIN AND THE PHYSIOLOGY OF PLATELET PRODUCTION (1996) (0)
TPO-Induced miR-150 Down-Regulates c-Myb in Primary Megakaryocytes and a Megakaryocytic Cell Line. (2007) (0)
Petition for Late Add / Drop or Late Registration Activity (2009) (0)
Graduate Program in Public Health Bulletin. (2011) (0)
Revised PhRMA Code Goes into Effect: Sunshine or More of the Same? (2009) (0)
Methods to increase the production of hematopoietic stem cells and platelets (2003) (0)
Lineage-speciﬁc growth factors can compensate for stem and progenitor cell deﬁciencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor–deﬁcient mice (2002) (0)
favorable effects of TPO on hematopoietic stem cells Thrombopoietin stimulates HoxB4 expression: an explanation for the (2013) (0)
ONGOING MONITORING POLICY (2012) (0)
Endomitotic MKs Undergo Cortical Contraction during Anaphase but Do Not Complete Furrow Ingression. (2006) (0)
Comprar Williams manual de hematología 8Ed | Marshall Al Lichtman | 9786071510006 | MCGRAW HILL (2014) (0)
Williams manual de hematología 8Ed (2014) (0)
thrombopoietin pretreated donor mice syngeneic transplantation of bone marrow cells derived from Accelerated reconstitution of platelets and erythrocytes after (2011) (0)
Defining units for thrombopoietin [letter] (1995) (0)
primitive hematopoietic progenitors of mice factor and other early acting cytokines in supporting proliferation of Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel (2011) (0)
Interleukin-l a Also Induces Granulocyte-Macrophage Colony-Stimulating Factor in Immature Normal Bone Marrow Cells (2003) (0)
interleukin-2 in cancer patients (see comments) interleukin-6 during intravenous administration of high-dose stimulating factor, macrophages colony-stimulating factor, and In vivo production of interleukin-5, granulocyte-macrophage colony- (2013) (0)
A Yearlong Celebration for ASH’s 50th (2008) (0)
Focal Adhesion Kinase in Megakaryopoiesis: A Study of Megakaryocyte-Specific FAK Deletion. (2006) (0)
A tribute to Ernest Beutler (2008) (0)
Thrombopoietin: Biological Effects Beyond Megakaryopoiesis (1997) (0)
10. Mentoring Physician-Scientists: Repairing the Leaky Pipeline (2016) (0)
Thrombopoietin (TPO): Basic biology, clinical promise (1995) (0)
THROMBOPOIETIN: AND MANIPULATING PLATELET PRODUCTION (1997) (0)
Special Issue Collection: In Memoriam (2015) (0)
The Homodimeric Hematopoietic Cytokine Receptor C-Mpl Requires Cross Phosphorylation in Order to Signal Cell Proliferation (2008) (0)
Methods for increasing the production of platelets, and hematopoietic stem cells (2003) (0)
Thrombopoietin: from cloning to clinic (2010) (0)
regulate receptor internalization and degradation YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor (2013) (0)
Contributors (2012) (0)
BIOLOGIC EFFECTS OF THROMBOPOIETIN (TPO) (1996) (0)
Erratum: Position statement, association of American physicians the imperative to invest in science has never been greater (Journal of Clinical Investigation (2014) 124:11 (5085) DOI:10.1172/JCI79469) (2014) (0)
Thrombopoietin induces megakaryocytic differentiation of embryonic stem cells in culture (1994) (0)
Myeloproliferative diseases: it’s beginning to make sense (2010) (0)
colony-stimulating factors and their synergistic actions Mechanisms of tumor-induced neutrophilia: constitutive production of (2011) (0)
Strange Bedfellows: Ludwig Wittgenstein and the National Institutes of Health on the Language of Pain (2012) (0)
Erythropoietin Stimulates Thrombopoiesis in the Absence of C-Mpl Signaling (2008) (0)
Megakaryocyte growth factors and acute myeloid leukemia. (1999) (0)
JAK2V617F-Mutant Megakaryocytes Contribute to Stem Cell Expansion in Myeloproliferative Neoplasms (2015) (0)
Functional Interaction Between c-MPL and Tensin2: A Novel and Potentially Important Pathway in Thrombopoietin Mediated Signaling. (2009) (0)
STONY BROOK UNIVERSITY MEDICAL CENTER UROLOGY GRAND ROUNDS (2012) (0)
Secretable Human Platelet-Derived Factor V Originates From the Plasma Pool (1998) (0)
Discover New Possibilities at the ASH BoothASH LEADERSHIP ELECTION RESULTS (0)
1 Visit 3 Vascular Screenings That Could Save Your Life (2011) (0)
COX-2 Inhibitors – The Consequences of Fooling With Physiology (2006) (0)
mapping of a neutralizing monoclonal antibody on a series of human-murine stem cell factor chimera and the Structure-function relationships of stem cell factor : an analysis based (2002) (0)
A tribute to Helen M. Ranney (2010) (0)
Glossary of molecular biology terminology. (1996) (0)
Lineage Restricted JAK2V617F Expression and Its Role in Thrombosis and Hemostasis; The Potential Involvement of Endothelial JAK2V617F in Clotting Abnormalities (2011) (0)

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