Kenneth R. Chien

Q: What Schools Are Affiliated With Kenneth R. Chien

Kenneth R. Chien is affiliated with the following schools: University of New South Wales, Icahn School of Medicine at Mount Sinai, University of California, San Diego, Institute of Science Tokyo, Ruhr University Bochum, University of Barcelona, Massachusetts General Hospital, Karolinska Institute, University of Utah, Harvard University

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Kenneth R. Chien

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Kenneth R. Chien's Degrees

Doctorate Medicine Harvard University

Why Is Kenneth R. Chien Influential?

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According to Wikipedia, Kenneth R. Chien is an American doctor and medical scientist who has been a research director at Karolinska Institute, in Stockholm, since 2013. Chien has several papers with over 1,000 citations and a h-index of 132. His area of expertise is cardiovascular science. His research into regenerative cardiovascular medicine, specifically while director of the Cardiovascular Program of the Harvard Stem Cell Institute, led to his co-founding, in 2010, of ModeRNA Therapeutics. In 2018, the company re-branded as Moderna, Inc. Chien is a recipient of the Walter Bradford Cannon Award of the American Physiology Society and the Pasarow Award. He is a member of the Norwegian Academy of Science and Letters, the Austrian Academy of Sciences, and has received an honorary doctorate from the University of Edinburgh.

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Kenneth R. Chien's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development (1999) (1712)
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages (2005) (1102)
Multipotent Embryonic Isl1 + Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification (2006) (1068)
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart (2008) (962)
Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family* (1998) (920)
PPAR gamma is required for placental, cardiac, and adipose tissue development. (1999) (911)
Signaling pathways for cardiac hypertrophy and failure. (1999) (893)
MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure (1997) (872)
ErbB2 is essential in the prevention of dilated cardiomyopathy (2002) (832)
Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response (1991) (801)
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages (2003) (797)
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. (1991) (796)
The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy (2002) (795)
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. (1994) (738)
Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress (1999) (704)
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. (1994) (671)
Conduction Slowing and Sudden Arrhythmic Death in Mice With Cardiac-Restricted Inactivation of Connexin43 (2001) (667)
Marked differences in differentiation propensity among human embryonic stem cell lines (2008) (659)
Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. (1990) (628)
Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization (2007) (628)
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity (2004) (617)
Fibulin-5/DANCE is essential for elastogenesis in vivo (2002) (609)
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. (1998) (561)
Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. (1995) (558)
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages (2009) (549)
Chronic Phospholamban–Sarcoplasmic Reticulum Calcium ATPase Interaction Is the Critical Calcium Cycling Defect in Dilated Cardiomyopathy (1999) (528)
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. (1999) (525)
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (1998) (524)
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511 (2010) (516)
An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation (2007) (512)
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2 (2003) (506)
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction (2013) (504)
Fashioning the vertebrate heart: earliest embryonic decisions. (1997) (497)
Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia. (1981) (490)
Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function (2004) (479)
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy (2002) (474)
Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies (2014) (466)
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis (2004) (464)
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice (2002) (449)
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure (2002) (445)
A Defect in the Kv Channel-Interacting Protein 2 (KChIP2) Gene Leads to a Complete Loss of I to and Confers Susceptibility to Ventricular Tachycardia (2001) (427)
Nkx2-5 Pathways and Congenital Heart Disease Loss of Ventricular Myocyte Lineage Specification Leads to Progressive Cardiomyopathy and Complete Heart Block (2004) (426)
Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway (1997) (415)
Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response. (1990) (392)
Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury. (1978) (390)
Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy (1996) (388)
Transthoracic echocardiography in models of cardiac disease in the mouse. (1996) (381)
Transcriptional regulation during cardiac growth and development. (1993) (370)
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery (2002) (367)
Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells* (1998) (359)
A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function (2001) (350)
Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. (1995) (344)
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes (2001) (340)
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. (2007) (339)
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages (2007) (331)
Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice (*) (1995) (330)
The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. (1993) (305)
Accumulation of Unesterified Arachidonic Acid in Ischemic Canine Myocardium: Relationship to a Phosphatidylcholine Deacylation‐Reacylation Cycle and the Depletion of Membrane Phospholipids (1984) (303)
Epicardial retinoid X receptor is required for myocardial growth and coronary artery formation (2005) (302)
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. (2004) (299)
Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. (1998) (299)
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. (1997) (286)
Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. (1999) (275)
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. (1999) (257)
Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine (2008) (256)
Islet1 cardiovascular progenitors: a single source for heart lineages? (2007) (254)
p38α Mitogen-Activated Protein Kinase Plays a Critical Role in Cardiomyocyte Survival but Not in Cardiac Hypertrophic Growth in Response to Pressure Overload (2004) (250)
The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitroand in Vivo Cardiac Hypertrophy* (1997) (249)
Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. (1994) (248)
Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. (1993) (243)
Towards regenerative therapy for cardiac disease (2012) (236)
Stem cells: Lost in translation (2004) (229)
Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. (2005) (228)
Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver (2000) (227)
Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research. (1997) (223)
Developmental changes in ionic channel activity in the embryonic murine heart. (1996) (222)
HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. (1993) (219)
Enhanced Myocardial Function inTransgenic Mice Overexpressing theP2-Adrenergic Receptor (1994) (216)
Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells (2009) (213)
Lives of a heart cell: tracing the origins of cardiac progenitors. (2008) (212)
Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. (1991) (212)
Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes (1996) (208)
Origins and Fates of Cardiovascular Progenitor Cells (2008) (206)
Phospholipid Alterations in Canine Ischemic Myocardium: Temporal and Topographical Correlations with Tc‐99m‐PPi Accumulation and an in Vitro Sarcolemmal Ca2+ Permeability Defect (1981) (201)
Genomic circuits and the integrative biology of cardiac diseases (2000) (198)
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. (2004) (194)
Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. (2003) (194)
Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. (1996) (193)
Bioengineering heart muscle: a paradigm for regenerative medicine. (2011) (192)
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. (1994) (192)
Herceptin and the heart--a molecular modifier of cardiac failure. (2006) (192)
Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction. (1979) (191)
Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. (2014) (191)
RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. (1996) (191)
Embryonic heart progenitors and cardiogenesis. (2013) (188)
Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells (2016) (188)
Adult mice deficient in actinin–associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy (2001) (186)
DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries* (1999) (186)
Prevention by chlorpromazine of ischemic liver cell death. (1977) (186)
Regeneration next: toward heart stem cell therapeutics. (2009) (185)
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. (2001) (184)
Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. (1995) (181)
Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. (2004) (180)
A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells (2013) (178)
Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function* (1998) (175)
In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation. (1993) (174)
Laminin-&agr;4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells (2007) (173)
Mixed signals in heart failure: cancer rules. (2002) (171)
Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. (2001) (169)
Molecular and physiological alterations in murine ventricular dysfunction. (1994) (164)
Cardiovascular effects of insulin-like growth factor-1 and growth hormone in chronic left ventricular failure in the rat. (1996) (162)
Growth and hypertrophy of the heart: towards an understanding of cardiac specific and inducible gene expression. (1993) (159)
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo (2007) (158)
Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. (2008) (157)
Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes. (1992) (156)
Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression. (1988) (154)
Converging Pathways and Principles in Heart Development and Disease CV@CSH (2002) (153)
Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. (2007) (148)
Erratum: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy (Proc. Natl. Acad. Sci. USA (September 1991) 88 (8277-8281)) (1991) (148)
Terminally differentiated neonatal rat myocardial cells proliferate and maintain specific differentiated functions following expression of SV40 large T antigen. (1988) (147)
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. (2005) (147)
Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. (2004) (143)
An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. (1996) (141)
Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. (2004) (139)
A Novel Genetic Pathway for Sudden Cardiac Death via Defects in the Transition between Ventricular and Conduction System Cell Lineages (2000) (139)
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. (2009) (138)
Mouse PeP: A novel peroxisomal protein linked to myoblast differentiation and development (2002) (138)
Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. (1999) (137)
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. (1996) (136)
Longevity and Lineages: Toward the Integrative Biology of Degenerative Diseases in Heart, Muscle, and Bone (2005) (133)
A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells (1991) (132)
Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells. (1990) (130)
Prox1 maintains muscle structure and growth in the developing heart (2009) (126)
How to make a cardiomyocyte (2014) (125)
Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression. (1989) (125)
The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. (2004) (124)
Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. (2004) (123)
A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression (1992) (121)
Identification of Cardiac-Specific Myosin Light Chain Kinase (2008) (119)
Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. (1985) (119)
Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. (2007) (118)
The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. (2003) (118)
The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes (1998) (115)
Regenerating the field of cardiovascular cell therapy (2019) (114)
Genes and physiology: molecular physiology in genetically engineered animals. (1996) (113)
Atrial Chamber-specific Expression of Sarcolipin Is Regulated during Development and Hypertrophic Remodeling* (2003) (113)
Physiological assessment of complex cardiac phenotypes in genetically engineered mice. (1997) (113)
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes (2019) (108)
Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. (1996) (108)
Retinoid-dependent pathways suppress myocardial cell hypertrophy. (1995) (108)
Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. (1996) (108)
A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy (2010) (107)
Deletion of 150 kb in the minimal DiGeorge/velocardiofacial syndrome critical region in mouse. (1999) (105)
Reduced Cardiac L-Type Ca2+ Current in Cavβ2−/− Embryos Impairs Cardiac Development and Contraction With Secondary Defects in Vascular Maturation (2006) (104)
Latent TGF‐β‐binding protein 2 binds to DANCE/fibulin‐5 and regulates elastic fiber assembly (2007) (104)
Restoration of Deficient Membrane Proteins in the Cardiomyopathic Hamster by In Vivo Cardiac Gene Transfer (2002) (104)
Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development (1997) (103)
Cardiac mechanotransduction and implications for heart disease (2003) (103)
Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. (2000) (101)
SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling* (2004) (101)
Regenerative medicine and human models of human disease (2008) (99)
Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos (2002) (98)
Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. (1998) (98)
Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid. (1985) (97)
Alpha 1-adrenergic stimulation of rat myocardial cells increases protein synthesis. (1986) (96)
Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. (2004) (96)
Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform (2006) (94)
Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. (1995) (94)
Synergistic Roles of Neuregulin-1 and Insulin-like Growth Factor-I in Activation of the Phosphatidylinositol 3-Kinase Pathway and Cardiac Chamber Morphogenesis* (1999) (93)
Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine (2018) (92)
Small proline‐rich protein 1A is a gp130 pathway‐ and stress‐inducible cardioprotective protein (2004) (91)
Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature (2011) (90)
Complexity in simplicity: monogenic disorders and complex cardiomyopathies. (1999) (89)
A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene (1993) (87)
Perinatal Loss of Nkx2-5 Results in Rapid Conduction and Contraction Defects (2008) (87)
Programming and reprogramming a human heart cell (2015) (86)
Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload. (1986) (85)
Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA (2013) (84)
Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart (2011) (84)
Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. (1995) (84)
The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements (1994) (80)
Cardiomyopathy Associated with Microcirculation Dysfunction in Laminin α4 Chain-deficient Mice* (2006) (78)
EFIA/YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene (1995) (77)
Meeting Koch's postulates for calcium signaling in cardiac hypertrophy. (2000) (77)
Innate Defense Mechanism Against Virus Infection Within the Cardiac Myocyte Requiring gp130-STAT3 Signaling (2006) (77)
Stem cell models of cardiac development and disease. (2010) (76)
Myocyte survival pathways and cardiomyopathy: implications for trastuzumab cardiotoxicity. (2000) (76)
Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization (2005) (75)
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. (2010) (75)
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression. (1999) (74)
Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice. (1997) (72)
Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. (2011) (71)
Molecular advances in cardiovascular biology. (1993) (70)
Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice (1994) (69)
Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. (1998) (68)
Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy. (1998) (66)
Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells (2014) (66)
High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates. (2000) (66)
Lost and found: cardiac stem cell therapy revisited. (2006) (66)
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing (2018) (63)
Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart. (1996) (62)
Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury (2016) (61)
The new Silk Road (2004) (59)
Microsomal membrane structure and function subsequent to calcium activation of an endogenous phospholipase. (1980) (58)
Thymosin β‐4 Is Essential for Coronary Vessel Development and Promotes Neovascularization via Adult Epicardium (2007) (57)
Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. (2019) (57)
A Novel Putative Protein-tyrosine Phosphatase Contains a BRO1-like Domain and Suppresses Ha-ras-mediated Transformation* (1998) (55)
Microsomal membrane dysfunction in ischemic rat liver cells. (1977) (54)
Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion. (1988) (54)
Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes. (1989) (51)
Calcium and heart failure: the cycle game (2003) (51)
Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion. (1985) (51)
Reversing advanced heart failure by targeting Ca2+ cycling. (2008) (51)
Effects of growth hormone on cardiac dysfunction and gene expression in genetic murine dilated cardiomyopathy (2000) (51)
Point Mutations in Human β Cardiac Myosin Heavy Chain Have Differential Effects on Sarcomeric Structure and Assembly: An ATP Binding Site Change Disrupts Both Thick and Thin Filaments, Whereas Hypertrophic Cardiomyopathy Mutations Display Normal Assembly (1997) (49)
In vivo high-efficiency transcoronary gene delivery and Cre–LoxP gene switching in the adult mouse heart (2003) (49)
The Muscle Ankyrin Repeat Proteins CARP, Ankrd2, and DARP Are Not Essential for Normal Cardiac Development and Function at Basal Conditions and in Response to Pressure Overload (2014) (48)
A Post-transcriptional Compensatory Pathway in Heterozygous Ventricular Myosin Light Chain 2-Deficient Mice Results in Lack of Gene Dosage Effect during Normal Cardiac Growth or Hypertrophy* (1999) (47)
Irreversible ischemic cell injury. Prevention by chlorpromazine of the aggregation of the intramembranous particles of rat liver plasma membranes. (1978) (47)
Deacylated lipopolysaccharide inhibits plasminogen activator inhibitor-1, prostacyclin, and prostaglandin E2 induction by lipopolysaccharide but not by tumor necrosis factor-alpha. (1990) (46)
Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes (2013) (46)
Heart myosin light chain 2 gene. Nucleotide sequence of full length cDNA and expression in normal and hypertensive rat. (1986) (46)
Slow progressive conduction and contraction defects in loss of Nkx2–5 mice after cardiomyocyte terminal differentiation (2009) (46)
Molecular medicine: MicroRNAs and the tell-tale heart (2007) (46)
In vivo murine cardiac hypertrophy : a novel model to identify genetic signaling mechanisms that activate an adaptive physiological response (1993) (44)
To Cre or not to Cre: the next generation of mouse models of human cardiac diseases. (2001) (44)
Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. (2014) (43)
Myotonic Dystrophy Protein Kinase Phosphorylates Phospholamban and Regulates Calcium Uptake in Cardiomyocyte Sarcoplasmic Reticulum* (2005) (43)
Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection. (2007) (42)
Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies. (2003) (42)
Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. (2006) (41)
Heart and lung disease in engineered mice (1995) (41)
Heterokaryons of cardiac myocytes and fibroblasts reveal the lack of dominance of the cardiac muscle phenotype (1994) (41)
Expression of diverse Na+ channel messenger RNAs in rat myocardium. Evidence for a cardiac-specific Na+ channel. (1989) (40)
Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. (2008) (39)
Nuclear Factor κB-inducing Kinase and IκB Kinase-α Signal Skeletal Muscle Cell Differentiation* (2001) (38)
Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. (2005) (37)
Characterization of a potentially reversible increase in beta-adrenergic receptors in isolated, neonatal rat cardiac myocytes with impaired energy metabolism. (1985) (36)
The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. (2007) (36)
Microinjection of Antibodies and Expression Vectors Into Living Myocardial Cells: Development of a Novel Approach to Identify Candidate Genes That Regulate Cardiac Growth and Hypertrophy (1992) (35)
ES Cells to the Rescue (2004) (35)
Effects of deletion of muscle LIM protein on myocyte function. (2001) (34)
Toward biologically targeted therapy of calcium cycling defects in heart failure. (2008) (34)
Neurofilament M mRNA is expressed in conduction system myocytes of the developing and adult rabbit heart. (1996) (34)
Unravelling Ras signals in cardiovascular disease (2004) (34)
Normal hematopoiesis after conditional targeting of RXRα in murine hematopoietic stem/progenitor cells (2006) (34)
N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment (2014) (33)
Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation. (1999) (33)
Signaling Pathways for Cardiac Growth and Hypertrophy (1995) (33)
Strategies for studying cardiovascular phenotypes in genetically manipulated mice. (1996) (32)
Amnion signals are essential for mesoderm formation in primates (2020) (32)
Cardiovascular Molecular Biology: Introduction to the Series (1989) (32)
Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology. (1995) (32)
Dobutamine stress cine‐MRI of cardiac function in the hearts of adult cardiomyocyte‐specific VEGF knockout mice (2001) (31)
Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration. (2019) (31)
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction (2018) (31)
Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA. (2014) (31)
Genetic modifiers of cardiac arrhythmias. (2003) (29)
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. (2009) (29)
Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies (2003) (29)
Tolerance induction to human stem cell transplants with extension to their differentiated progeny (2014) (28)
Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. (2006) (28)
Molecular Basis of Cardiovascular Disease: A companion to Braunwald's Heart Disease (1999) (26)
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways (2021) (26)
Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. (2013) (24)
Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos. (1998) (24)
Developmental expression of the murine spliceosome‐associated protein mSAP49 (1997) (23)
Targeting gene expression to specific cardiovascular cell types in transgenic mice. (1993) (23)
Thymosin beta 4 is essential for coronary vessel development and promotes neovascularisation via adult epicardium (2007) (23)
Nucleotide sequence of full length cDNAs encoding rat cardiac myosin light chain-2. (1988) (23)
Development. ES cells to the rescue. (2004) (22)
Expression of SV40 virus large T antigen by recombinant adenoviruses activates proliferation of corneal endothelium in vitro. (1993) (22)
Induction of a reversible cardiac lipidosis by a dietary long-chain fatty acid (erucic acid). Relationship to lipid accumulation in border zones of myocardial infarcts. (1983) (22)
Inflammatory pathways and cardiac repair: the affliction of infarction (1999) (22)
Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation. (2001) (22)
Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression. (2007) (22)
Congenital long QT syndromes. Toward molecular dissection of arrhythmia substrates. (1995) (21)
Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells (2016) (21)
A novel A/T-rich element mediates ANF gene expression during cardiac myocyte hypertrophy. (1997) (21)
Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. (2019) (21)
Shortcuts to making cardiomyocytes (2011) (21)
Cardiac origin of smooth muscle cells in the inflow tract. (2011) (20)
[26]Molecular analysis of cardiac muscle diseases based on mouse genetics (1996) (19)
In vivo esterification of a synthetic 125I-labeled fatty acid into cardiac glycerolipids. (1983) (19)
Targeted conditional gene knockout in human embryonic stem cells (2010) (19)
Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. (2007) (18)
The Pathogenesis of Irreversible Cell Injur in Ischemia (2007) (18)
Reduced arachidonate metabolism in ATP-depleted myocardial cells occurs early in cell injury. (1990) (18)
Left ventricular volumes and function in the embryonic mouse heart. (1997) (18)
Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction. (1998) (17)
The MLP family of cytoskeletal Z disc proteins and dilated cardiomyopathy: a stress pathway model for heart failure progression. (2002) (16)
The MLC-2 Paradigm for Ventricular Heart Chamber Specification, Maturation, and Morphogenesis (1999) (16)
Multipotent islet-1 cardiovascular progenitors in development and disease. (2008) (16)
Z-line proteins: implications for additional functions (2002) (15)
Membrane phospholipid metabolism during myocardial ischaemia: past, present and future. (1987) (15)
Cre-constructing the heart (2003) (15)
Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells (2014) (15)
VEGFA mRNA for regenerative treatment of heart failure (2021) (14)
Membrane damage in ischemia. (1983) (14)
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor‐derived cardiac fibroblast lineage (2020) (14)
Unlocking the promise of mRNA therapeutics (2022) (14)
Laminin- 4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells (2007) (13)
Molecular medicine in genetically engineered animals: series introduction. (1996) (12)
Muscle LIM protein in heart failure. (2002) (12)
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy (2021) (12)
Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors (2020) (12)
The molecular genetics of retinoic acid receptors: cardiovascular and limb development. (1996) (12)
Fatty acylcarnitine accumulation and membrane injury in ischemic canine myocardium. (1983) (12)
Prox1 maintains muscle structure and growth in the developing heart (2009) (12)
SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation (2018) (11)
Relationship of mitochondrial alterations and 99mTc pyrophosphate uptake during myocardial ischemia. (1982) (11)
Reprogramming a broken heart. (2012) (11)
Molecular biology of tissue plasminogen activator and endogenous inhibitors. (1986) (11)
Alchemy and the New Age of Cardiac Muscle Cell Biology (2005) (10)
Cardiotrophin-1, a novel cytokine that induces cardiac myocyte hypertrophy (1994) (10)
Effects of calcium loading and impaired energy production on metabolic and ultrastructural features of cell injury in cultured neonatal rat cardiac myocytes. (1990) (10)
Cardiomyocyte reprogramming and the new age of cellular alchemy. (2012) (10)
chapter 5 – Mouse Models of Human Cardiovascular Disease (2004) (9)
Of molecules and myocardium. PCR diagnosis of viral myocarditis in cardiac biopsies. (1990) (9)
Toward molecular strategies for heart disease--past, present, future. (1997) (9)
Heart Regeneration 4.0: Matrix Medicine. (2017) (8)
Influence of chlorpromazine on lysosomal alterations during myocardial ischaemia. (1983) (8)
Genetic engineering of cardiac muscle cells: in vitro and in vivo. (1994) (7)
Beyond small molecule drugs for heart failure: prospects for gene therapy. (2006) (7)
Prevention by chlorpromazine of ischemic cell death (1977) (7)
Erratum: Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy (Human Molecular Genetics (2008) vol. 17 (18) (2753-2765) 10.1093/hmg/ddn160) (2008) (7)
Next-generation models of human cardiogenesis via genome editing. (2014) (6)
Heart-to-heart. New approaches for gene transfer in the myocardium. (1991) (6)
Close encounters with ET-1. (1995) (6)
Essential amnion signals for primate primitive streak formation resolved by scRNA map (2020) (6)
Genomic circuits and the integrative biology of cardiomyopathies (2001) (6)
Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders (2022) (6)
Erratum: Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells (2015) (6)
An IGF 1 R-dependent pathway drives epicardial adipose tissue formation after myocardial injury (2017) (6)
A genetic based model of cardiac hypertrophy in MLC-ras mice. (1996) (6)
Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI. (2022) (5)
Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. (2008) (5)
Longevity and Lineages: Toward the Integrative Biology of Degenerative Diseases in Heart, Muscle, and Bone (2005) (5)
In vivo reprogramming for heart disease (2012) (5)
Phospholipid alterations and membrane injury during myocardial ischemia. (1985) (4)
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors (2022) (4)
Superselective endovascular tissue access using trans‐vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine (2018) (4)
Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis (2021) (4)
Altered calcium homeostasis and membrane integrity in myocardial cell injury. (1988) (4)
Stem Cells 1 Towards regenerative therapy for cardiac disease (2012) (3)
Stem Cells 1 Towards regenerative therapy for cardiac disease (2012) (3)
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction (2020) (3)
Final general discussion (2006) (3)
Cardiac regenerative medicine 2.0 (2013) (3)
chapter 11 – Development of Cardiac Pacemaking and Conduction System Lineages (2004) (3)
Ischemic Myocardial Cell Injury (2007) (3)
Of mouse and man: molecular switches that control cardiac growth and development. (1993) (3)
Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting. (2022) (3)
Inhibition of arachidonic acid release protects myocardial cell viability during ATP depletion (1986) (3)
Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors (2021) (3)
Fatty acyl metabolites and membrane injury in ischemic canine myocardium: Dissociation from a sarcolemmal Ca++ permeability defect and correlation with mitochondrial dysfunction (1981) (2)
p 53 Is a Transcriptional Activator of the Muscle-specific Phosphoglycerate Mutase Gene and Contributes in Vivo to the Control of Its Cardiac Expression 1 (2000) (2)
Regenerating physician-scientists (2010) (2)
Reply to ‘Re-evaluating sarcoplasmic reticulum function in heart failure’ (2000) (2)
Membrane Phospholipid Metabolism during Myocardial Ischemia: Mechanisms of Accumulation of Unesterified Arachidonate (1984) (2)
Committed Ventricular Progenitors in the Islet-1 Lineage Expand and Assemble Into Functional Ventricular Heart Muscle (2009) (2)
Abstract 15533: A Biocompatible Chemically Modified mRNA Drives Sustained VEGF-A Protein Production, Human Endothelial Angiogenesis and Epicardial Progenitor Expansion, and Reduces Infarct Size and Partially Reverses Global Cardiac Dysfunction When Intracardially Injected One Week Post-Myocardial In (2016) (2)
Expression of cardiac muscle markers in rat myocyte cell lines (1996) (2)
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure (2022) (2)
chapter 15 – Molecular Pathways for Cardiac Hypertrophy and Heart Failure Progression (2004) (2)
Primate heart regeneration via migration and fibroblast repulsion by human heart progenitors (2020) (2)
Embryonic and neonatal cardiac gene transfer in vivo. (2003) (2)
Model‐Based Analysis Reveals a Sustained and Dose‐Dependent Acceleration of Wound Healing by VEGF‐A mRNA (AZD8601) (2020) (2)
Genetic complementation identifies phospholamban- sarcoplasmic reticulum Ca ATPase interaction as the primary defect that drives the onset of heart failure in dilated cardiomyopathy (1999) (2)
chapter 25 – Coronary Restenosis (2004) (2)
chapter 1 – Biotechnology and Cardiovascular Medicine: Recombinant Protein Therapy (2004) (1)
Alpha-1 adrenergic stimulation of cardiac gene transcription in cultured neonatal rat myocardial cells: Effects on myosin light chain-2 gene expression (1987) (1)
In search of the next super models (2019) (1)
Good fences make good neighbors : cardiovascular science and medicine at the end of the millenium. (1999) (1)
Next generation partnerships in translational science and medicine (2015) (1)
Erratum: Prox1 maintains muscle structure and growth in the developing heart (Development (2008) vol. 136 (495-505)) (2009) (1)
Tangled up in blue: molecular cardiology in the postmolecular era. (1997) (1)
Irreversible Ischemic Cell Injury (2007) (1)
Lnc'ed in to Cardiogenesis. (2018) (1)
Abstract 1103: Integrin-linked Kinase and Laminin alpha 4 Mutations Cause Human Cardiomyopathy (2007) (1)
Synergistic interaction between a ubiquitous and a distinct muscle factor form an e box independent pathway for cardiac muscle gene expression (1992) (1)
Recent advances in the molecular biology of cardiac growth and hypertrophy: of mouse and man. (1992) (1)
chapter 6 – Toward Stem Cell Therapy (2004) (1)
chapter 28 – Blood Coagulation and Atherothrombosis (2004) (1)
Mechanisms of dilated cardiomyopathies (2004) (1)
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation (2021) (1)
P6348Phospholamban antisense oligonucleotides drive the reversal of cardiac dysfunction and multiple heart failure parameters during murine dilated cardiomyopathy (2019) (1)
Regenerative biology: Heartbroken embryos heal (2013) (1)
PHF7 directs cardiac reprogramming (2021) (1)
The leak stops here: platelets as delivery vehicles for coagulation factors (2006) (0)
Molecular cardiology in the postmolecular era Turning toward complexity. (1996) (0)
Abstract 1102: Cardiac-Specific Myosin Light Chain Kinase (MLCK), a Third Member of MLCK Family, Potentiates Sarcomere Formation and Cardiac Contraction (2007) (0)
Heterokaryons ofCardiac Myocytes andFibroblasts Revealthe LackofDominance oftheCardiac MusclePhenotype (1994) (0)
OJ-504 Functional alterations of TCAP mutations found in hypertrophic cardiomyopathy and dilated cardiomyopathy(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese)) (2004) (0)
Expression of plasminogen activator inhibitor-1 in human endothelial cells and surrogate cell systems (1987) (0)
MLP, muscle lim protein is a component of a mechano-sensor pathway in cardiac myocytes (1999) (0)
REGULATION DURING CARDIAC GROWTH AND DEVELOPMENT (1993) (0)
Induction of HSP71 mRNA and irreversible injury in neonatal rat myocardial cells following ATP depletion (1990) (0)
Ischemia induced arachidonate release in the isolated heart (1984) (0)
STATs in the Cardiovascular System (2003) (0)
Cardiac origin of smooth muscle cells in the in fl ow tract 3 (2010) (0)
Transcriptional regulation of the ANF and MLC-2 genes during cardiac growth and development (1991) (0)
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation (2021) (0)
Effects of growth hormone on cardiac function in murine model of dilated cardiomyopathy due to disruption of muscle lim protein gene (1998) (0)
STRUCTURE, TISSUE-SPECIFIC AND INDUCIBLE EXPRESSION OF THE RAT CARDIAC MYOSIN LIGHT CHAIN-2 GENE: 4 (1980) (0)
RXRα Null Haematopoietic Cells Fail To Reconstitute Haematopoiesis in Lethally Irradiated Recipient Mice. (2004) (0)
Multiple computational modeling approaches for prediction of wound healing dynamics following pharmacologic intervention (2017) (0)
Negative mutant for use in the treatment of heart disease dominant PLB. (2001) (0)
A GPS for heart progenitor cell lineages. (2011) (0)
Something Old, Something New, Something Borrowed, Something Blue (2002) (0)
IS045 Genetic Dissection of Complex Cardiac Function (1998) (0)
Results Development of Microsurgical Technology for the Delivery of Recombinant Adenoviruses Via Direct Intracardiac Chamber Injection in Living Murine Embryos (1999) (0)
Calcium cycling defects and cardiomyopathy (2002) (0)
Targeted disruption of the tropomodulin gene in mice (1999) (0)
Phospholipid alterations in ischemic myocardium: Correlations with a sarcolemmal Ca++ permeability defect and 99mTc-PYP uptake (1980) (0)
Effects of gene transfer of urokinase-type plasminogen activator on extracellular matrix and ventricular remodeling in swine (2003) (0)
Abstract 1920: Nkx2-5-dependent Transcriptional Regulation of ANF and BNP Through a Common Distal Enhancer (2009) (0)
Regenerative Cardiovascular Medicine Cardiogenesis and the Complex Biology of (2009) (0)
Retinoid Signaling: Insight from Genetically Engineered Mice (1999) (0)
chapter 12 – Cardiac Laterality and Congenital Heart Disease (2004) (0)
Blood Coagulation and Atherothrombosis Hiroshi Ashikaga (2004) (0)
WITHDRAWN: Heart function in adult cardiac Serca2null mice (2007) (0)
Recombinant adenovirus of tissue-specific gene expression in the heart (1999) (0)
Cardiotrophin and their uses. (1995) (0)
Abstract 15665: Ablation of Nkx2-5 Beginning at Mid-Embryonic Stage Results in Premature Lethality and Cardiac Malformation (2010) (0)
VEGFA mRNA for regenerative treatment of heart failure (2021) (0)
Title Cardiac-specific disruption of the c-raf-1 geneinduces cardiac dysfunction and apoptosis (0)
Abstract 20267: Bipotency of Late Cardiac Progenitors; a Possible Role of the Plasticity of Isl1/SLN Atrial Progenitors in Boundary Formation in Cardiac Inflow Tract via Myocardin-dependent Pathway (2010) (0)
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing (2018) (0)
[Developmental genes and heart disease]. (2001) (0)
Methane-Consuming Microbial Consortia Deep-Sea Archaea Fix and Share Nitrogen in (2010) (0)
Molecular basis of antibody memory(Mashimo Memorial Lecture,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society) (2008) (0)
Corrigendum to "Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration" [Semin. Cell Dev. Biol. Vol.100 (2020) 29-51]. (2020) (0)
Inside Lab Invest (2009) (0)
特別講演) Mapping signaling pathways for cardiac ventricular chamber growth and development via mouse genetics (1995) (0)
Title Driving vascular endothelial cell fate of human multipotent Isl 1 + heart progenitors with VEGF modified mRNA (2013) (0)
METABOLISM OF RADIOIODINATED &ohgr;‐PHENYL PENTADECANOIC ACID (I‐PPA) IN RAT MYOCARDIUM.: B3 (1983) (0)
Abstract 1710: Knockdown of Nkx2.5 Results in Altered Sarcomere Organization and Cell Shape (2006) (0)
Sarcolipin, a Novel Calcium Regulator, Is Preferentially Expressedin the Atrium and Is Downregulated in the Hypertrophic Heart (2003) (0)
Sources of Autologous Cell-Based Therapy for Cardiac Disease : Blood and Skeletal Muscle Progenitors ? (0)
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LXXIII (2009) (0)
Regenerating the field of cardiovascular cell therapy (2019) (0)
Molecular Physiology of Ventricular Hypertrophy (1994) (0)
High efficiency expression of foreign genes in primary cultures of neonatal rat myocardial cells during alpha adrenergic stimulation: Utility of a novel recombinant human adenovirus vector (1987) (0)
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes (2019) (0)
Something old, something new, something borrowed, something blue: notes on TCM ten years after. (2002) (0)
chapter 4 – Generation and Cloning of Genetically Modified Animals (2004) (0)
Deep-Sea Archaea Fix and Share Nitrogen in Methane-Consuming Microbial Consortia (2009) (0)
Heart function in adult cardiac Serca2null mice (2007) (0)
Induction of a program of immediate early gene expression and ANF during acute and chronic mechanical pressure overload in murine myocardium in vivo (1991) (0)
474: Identification of Cells Expressing the Isl1 Cardiac Progenitor Marker in Miniature Swine (2008) (0)
Molecular Analysis of Cardiac Growth and Development in Transgenic Mouse Model Systems (1993) (0)
41. High Efficiency, Catheter-Based, Gene Transfer to the Large Animal Heart (2005) (0)
Cardiomyocyte-specific and global inactivation of the β2 subunit gene of the voltage-dependent Ca 2+ channel in the mouse (2004) (0)
Targeted inactivation of the murine cardiac myosin-binding protein C gene leads to hypertrophic cardiomyopathy (2002) (0)
Rosiglitizone treatment does not improve insulin sensitivity in mice with whole body CAP gene deletion (2006) (0)
Focus : Induced Pluripotency & Cellular Reprogramming Programming and reprogramming a human heart cell (2015) (0)
S13-01 Master heart progenitor cells (2009) (0)
Myocardial Arachidonate Metabolism during ATP Depletion (1985) (0)
Abstract 1247: Heart Function is Transiently Sustained Despite a Near Loss of SERCA2 Protein in Cardiomyocyte-specific Serca2null Mice (2007) (0)

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