Kenneth S. Kosik

Q: What Schools Are Affiliated With Kenneth S. Kosik

Kenneth S. Kosik is affiliated with the following schools: Université de Montréal, University of California, Santa Barbara, Drexel University, Rockefeller University, University of Virginia, Harvard University

Kenneth S. Kosik's AcademicInfluence.com Rankings

Kenneth S. Kosik

Medical

#995

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#1278

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Neurology

#106

World Rank

#163

Historical Rank

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Why Is Kenneth S. Kosik Influential?

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According to Wikipedia, Kenneth S. Kosik is an American neurologist, author, researcher and professor in neuroscience at the University of California, Santa Barbara. Recent contributions includes a significant discovery in understanding the way human embryonic stem cells function. He has contributed to novel thinking about how to reduce risk for getting Alzheimer's disease and reduce the impact of this illness on our communities. He was the founder and executive director of Cognitive Fitness & Innovative Therapies, followed by the Cottage Center for Brain Fitness. Kosik provided much of the original data on the largest family in the world with a genetic form of Alzheimer's disease located in Antioquia, Colombia.

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Kenneth S. Kosik's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. (2005) (2562)
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. (1986) (1291)
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells (2009) (1150)
Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease (2001) (1064)
A microRNA array reveals extensive regulation of microRNAs during brain development. (2003) (1052)
The Amphimedon queenslandica genome and the evolution of animal complexity (2010) (957)
The neuronal microRNA system (2006) (795)
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008) (703)
Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis (2006) (684)
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons (1990) (652)
Structure and novel exons of the human tau gene. (1992) (609)
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons (2003) (599)
Developmentally regulated expression of specific tau sequences (1989) (574)
Neuronal RNA Granules A Link between RNA Localization and Stimulation-Dependent Translation (2001) (533)
Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. (1986) (529)
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology (1996) (501)
Epitopes that span the tau molecule are shared with paired helical filaments (1988) (485)
MicroRNA profiling of the murine hematopoietic system (2005) (471)
The microtubule binding domain of tau protein (1989) (461)
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families (1995) (461)
Synaptic dysregulation in a human iPS cell model of mental disorders (2014) (456)
CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival* (2004) (445)
Translocation of RNA Granules in Living Neurons (1996) (435)
Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study (2012) (422)
Sorting of β-Actin mRNA and Protein to Neurites and Growth Cones in Culture (1998) (396)
Neuritic pathology and dementia in alzheimer's disease (1991) (376)
Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease (1987) (348)
A detergent-insoluble membrance compartment contains Aβ in vivo (1998) (327)
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. (2002) (325)
Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. (2011) (325)
MicroRNAs Potentiate Neural Development (2009) (321)
Pathological changes in olfactory neurons in patients with Alzheimer's disease (1989) (315)
Presenilin 1 interaction in the brain with a novel member of the Armadillo family (1997) (310)
CaMKIIα 3′ Untranslated Region-Directed mRNA Translocation in Living Neurons: Visualization by GFP Linkage (2000) (284)
Overexpression of tau in a nonneuronal cell induces long cellular processes (1991) (284)
A Post-Synaptic Scaffold at the Origin of the Animal Kingdom (2007) (283)
Suppression of MAP2 in cultured cerebeller macroneurons inhibits minor neurite formation (1992) (278)
Alzheimer's disease: a cell biological perspective. (1992) (274)
Identification of piRNAs in the central nervous system. (2011) (262)
Heterogeneous dysregulation of microRNAs across the autism spectrum (2008) (254)
A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation (2009) (242)
Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. (1995) (238)
The Outer Subventricular Zone and Primate-Specific Cortical Complexification (2015) (230)
In vivo phosphorylation sites in fetal and adult rat tau. (1993) (227)
Synaptic tagging — who's it? (2002) (222)
Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. (1984) (222)
Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study (2012) (222)
LRP1 is a master regulator of tau uptake and spread (2020) (217)
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease (2020) (216)
Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. (1998) (213)
Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. (2007) (202)
Microtubule-associated protein tau (? ) is a major antigenic component of paired helical filaments in Alzheimer disease (1987) (197)
Resistance to autosomal dominant Alzheimer’s in an APOE3-Christchurch homozygote: a case report (2019) (196)
RNA stores tau reversibly in complex coacervates (2017) (194)
MicroRNA Regulation of Neural Stem Cells and Neurogenesis (2010) (193)
A detergent-insoluble membrane compartment contains A beta in vivo. (1998) (191)
δ-catenin, an Adhesive Junction–associated Protein Which Promotes Cell Scattering (1999) (190)
Evidence for the Involvement of Tiam1 in Axon Formation (2001) (189)
Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. (1987) (186)
RNAi functions in cultured mammalian neurons (2002) (186)
Binding of Tau to Heat Shock Protein 27 Leads to Decreased Concentration of Hyperphosphorylated Tau and Enhanced Cell Survival* (2004) (183)
Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides (1992) (182)
Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases (2012) (181)
Selective Phosphorylation of Adult Tau Isoforms in Mature Hippocampal Neurons Exposed to Fibrillar Aβ (1997) (177)
Clinical Features of Early-Onset Alzheimer Disease in a Large Kindred With an E280A Presenilin-1 Mutation (1997) (173)
A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells (2014) (171)
Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. (1994) (164)
Suppression of Radixin and Moesin Alters Growth Cone Morphology, Motility, and Process Formation In Primary Cultured Neurons (1998) (161)
Microtubular reorganization and dendritic growth response in alzheimer's disease (1989) (160)
Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice (2010) (159)
Apolipoprotein Eε4 modifies Alzheimer's disease onset in an E280A PS1 kindred (2003) (157)
Kinesin-mediated organelle translocation revealed by specific cellular manipulations (1994) (156)
The Erbin PDZ Domain Binds with High Affinity and Specificity to the Carboxyl Termini of δ-Catenin and ARVCF* (2002) (156)
Deletion of the Neuron-Specific Protein Delta-Catenin Leads to Severe Cognitive and Synaptic Dysfunction (2004) (155)
The Elegance of the MicroRNAs: A Neuronal Perspective (2005) (154)
Hemizygosity of δ-Catenin (CTNND2) Is Associated with Severe Mental Retardation in Cri-du-Chat Syndrome (2000) (153)
Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization (1991) (148)
BACE1 Suppression by RNA Interference in Primary Cortical Neurons* (2004) (148)
The pool of map kinase associated with microtubules is small but constitutively active. (1996) (147)
Delayed Retraction of Filopodia in Gelsolin Null Mice (1997) (147)
The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule (2009) (143)
Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. (2006) (141)
Nrf2, a Regulator of the Proteasome, Controls Self‐Renewal and Pluripotency in Human Embryonic Stem Cells (2014) (139)
MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth. (1996) (137)
Association of poly(A) mRNA with microtubules in cultured neurons (1994) (135)
Phosphorylated tau and the neurodegenerative foldopathies. (2005) (131)
Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease (2013) (130)
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) (2017) (129)
MicroRNAs: regulators of oncogenesis and stemness (2008) (128)
Noncoding RNAs in Long-Term Memory Formation (2008) (127)
SMN regulates axonal local translation via miR-183/mTOR pathway. (2014) (126)
The Molecular and Cellular Biology of Tau (1993) (123)
CHIP and HSPs interact with β-APP in a proteasome-dependent manner and influence Aβ metabolism (2007) (123)
Competition for microtubule-binding with dual expression of tau missense and splice isoforms. (2001) (122)
Distinct Roles of Synapsin I and Synapsin II during Neuronal Development (1998) (119)
Dual regulation of neuronal morphogenesis by a δ-catenin–cortactin complex and Rho (2003) (115)
Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders (1987) (115)
Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells (2013) (115)
MicroRNAs and Cellular Phenotypy (2010) (114)
Measuring Alzheimer’s disease progression with transition probabilities (2001) (113)
Activation of the neuronal c-Abl tyrosine kinase by amyloid-β-peptide and reactive oxygen species (2004) (113)
A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA (2016) (112)
Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase (1990) (110)
Public attitudes about genetic testing for Alzheimer's disease. (2001) (105)
Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity. (1993) (105)
MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. (2010) (104)
Highly Conserved O-Fucose Sites Have Distinct Effects on Notch1 Function*♦ (2005) (103)
Human GAP 43: Its deduced amino acid sequence and chromosomal localization in mouse and human (1988) (103)
MOV10 and FMRP regulate AGO2 association with microRNA recognition elements. (2014) (101)
Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. (2015) (99)
Relative exon affinities and suboptimal splice site signals lead to non-equivalence of two cassette exons. (1995) (98)
Tau Epitopes are Incorporated into a Range of Lesions in Alzheimer's Disease (1987) (97)
Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred. (2003) (96)
Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons. (1994) (95)
Particle display: a quantitative screening method for generating high-affinity aptamers. (2014) (95)
A Scalable, Easy-to-Deploy Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material (2020) (94)
Tau protein and Alzheimer's disease. (1990) (94)
Hirano bodies contain tau protein (1987) (94)
Microtubule-associated Protein 2c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280–deficient Melanoma Cell Line (1997) (93)
Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism‐dementia of guam (1989) (92)
Transcriptional profiling reveals regulated genes in the hippocampus during memory formation (2002) (90)
Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture. (1995) (90)
Stabilization of the Tau Exon 10 Stem Loop Alters Pre-mRNA Splicing* (2006) (89)
A molecular signature for anastasis, recovery from the brink of apoptotic cell death (2017) (89)
Deep annotation of mouse iso-miR and iso-moR variation (2012) (89)
Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development (2018) (89)
The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain (1988) (88)
E280A PS‐1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles (1997) (88)
Tau confers drug stability but not cold stability to microtubules in living cells. (1994) (87)
Tau in situ hybridization in normal and alzheimer brain: Localization in the somatodendritic compartment (1989) (87)
Expression and distribution of microtubule-associated protein 2 (MAP2) in neuroblastoma and primary neuronal cells. (1986) (87)
FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease. (2016) (87)
Architecture of apical dendrites in the murine neocortex: Dual apical dendritic systems (1986) (86)
CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. (2007) (85)
The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau. (1997) (82)
Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability (2016) (81)
δ‐catenin is a nervous system‐specific adherens junction protein which undergoes dynamic relocalization during development (2000) (81)
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS (2015) (81)
Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate (2016) (80)
MUC1* Mediates the Growth of Human Pluripotent Stem Cells (2008) (80)
Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome. (2000) (79)
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions (2018) (75)
Ontogenesis of microtubule-associated protein 2 (MAP2) in embryonic mouse cortex. (1986) (74)
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis (2019) (73)
The primary structure and analysis of the squid kinesin heavy chain. (1990) (73)
Suppression of KIF2 in PC12 Cells Alters the Distribution of a Growth Cone Nonsynaptic Membrane Receptor and Inhibits Neurite Extension (1997) (73)
Detection of a MicroRNA Signal in an In Vivo Expression Set of mRNAs (2007) (73)
Neurotrophin-3 signals redistribute RNA in neurons. (1997) (72)
Novel Primate miRNAs Coevolved with Ancient Target Genes in Germinal Zone-Specific Expression Patterns (2014) (68)
Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleotide. (1993) (67)
A δ-Catenin Signaling Pathway Leading to Dendritic Protrusions* (2008) (66)
Basal Extracellular Signal-Regulated Kinase Activity Modulates Cell-Cell and Cell-Matrix Interactions (1998) (66)
Huntington's disease: Changes in striatal proteins reflect astrocytic gliosis (1982) (65)
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. (2005) (65)
MicroRNA-124: micromanager of neurogenesis. (2009) (65)
Nrf 2 , a regulator of the proteasome , controls self-renewal and pluripotency in human embryonic stem cells (2014) (64)
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy (2019) (64)
Mechanisms of age-related cognitive change and targets for intervention: epigenetics. (2012) (63)
Functionalization of a protosynaptic gene expression network (2012) (62)
Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL. (2004) (62)
Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. (2016) (61)
Microtubule destabilization and neurofilament phosphorylation precede dendritic sprouting after close axotomy of lamprey central neurons. (1991) (60)
NMDA Mediated Contextual Conditioning Changes miRNA Expression (2011) (59)
Microglial microRNAs mediate sex-specific responses to tau pathology (2019) (57)
δ-Catenin at the synaptic–adherens junction (2005) (57)
Accelerated neuronal differentiation induced by p53 suppression. (1996) (56)
CADASIL mutations impair Notch3 glycosylation by Fringe. (2005) (56)
Cofactors are essential constituents of stable and seeding-active tau fibrils (2018) (54)
Brain armadillo protein δ‐catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors (2002) (53)
Process formation in Sf9 cells induced by the expression of a microtubule-associated protein 2C-like construct. (1993) (53)
Parallel Discovery of Alzheimer’s Therapeutics (2014) (52)
Presenilin Affects Arm/β-Catenin Localization and Function in Drosophila (2000) (50)
Dementia in Latin America: Paving the way toward a regional action plan (2020) (49)
Partial Sequence of MAP2 in the Region of a Shared Epitope with Alzheimer Neuronbrillary Tangles (1988) (48)
MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes (2016) (48)
Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth. (1996) (48)
Human neural tube morphogenesis in vitro by geometric constraints (2021) (47)
MicroRNAs tell an evo–devo story (2009) (47)
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies (2019) (47)
Attenuated Hippocampus-Dependent Learning and Memory Decline in Transgenic TgAPPswe Fischer-344 Rats (2004) (46)
Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau (2020) (46)
Molecular biology: Circles reshape the RNA world (2013) (46)
Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions (2012) (45)
Inhibition of Kinesin Synthesis In Vivo Inhibits the Rapid Transport of Representative Proteins for Three Transport Vesicle Classes into the Axon (1995) (45)
Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models*♦ (2013) (45)
Amino-terminal region of the β-amyloid precursor protein activates mitogen-activated protein kinase (1995) (44)
Delta-catenin at the synaptic-adherens junction. (2005) (43)
Evolutionary expansion and specialization of the PDZ domains. (2010) (43)
A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle. (1986) (43)
Tau protein and the establishment of an axonal morphology (1991) (43)
The proline-rich domain promotes Tau liquid–liquid phase separation in cells (2020) (43)
A τ Promoter Region Without Neuronal Specificity (1996) (42)
Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells. (1994) (42)
Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease (2014) (41)
Cytoskeletal changes correlated with the loss of neuronal polarity in axotomized lamprey central neurons (1997) (41)
Organization of actin and microtubules during process formation in tau-expressing Sf9 cells. (1994) (41)
Gα12 Directly Interacts with PP2A (2004) (40)
Life at Low Copy Number: How Dendrites Manage with So Few mRNAs (2016) (39)
Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer’s Disease: A Comprehensive Review of the Colombian Kindred (2019) (39)
Heterogeneity of microtubule-associated protein (MAP2) in vertebrate brains (1987) (38)
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer’s mice (2014) (37)
Alzheimer plaques and tangles: advances on both fronts (1991) (37)
Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells. (1992) (37)
Phosphorylated baculovirus p10 is a heat-stable microtubule-associated protein associated with process formation in Sf9 cells. (1992) (36)
New approaches to the discovery of cdk5 inhibitors. (2007) (35)
The mammalian RNA-binding protein staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons (2007) (34)
Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to cross-reaction with tau protein (1987) (34)
The Message and the Messenger: Delivering RNA in Neurons (2002) (34)
Statistical analysis of dendritic spine distributions in rat hippocampal cultures (2013) (33)
A tau promoter region without neuronal specificity. (1996) (33)
Pathologic Changes in Olfactory Neurons in Alzheimer's Disease a (1991) (32)
The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science (2021) (32)
Cholinergic Function in Lumbar Aluminum Myelopathy (1983) (32)
Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors. (2011) (31)
Exploring the early origins of the synapse by comparative genomics (2008) (31)
Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation. (2015) (31)
The Alzheimer's disease sphinx: a riddle with plaques and tangles (1994) (30)
Microtubule-associated protein 2 (MAP 2) immunoreactivity in human fetal neocortex (1988) (30)
MUC1* Ligand, NM23-H1, Is a Novel Growth Factor That Maintains Human Stem Cells in a More Naïve State (2013) (28)
Postsynaptic Element Contributes to the Delay in Synaptogenesis in Synapsin I-Deficient Neurons (1996) (28)
Secreted β-APP stimulates MAP kinase and phosphorylation of tau in neurons (1995) (27)
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. (2004) (27)
Along the way to a neurofibrillary tangle: a look at the structure of tau. (1989) (27)
Spatial Learning and Memory Is Preserved in Rats after Early Development in a Microgravity Environment (2002) (27)
The exon trapping assay partly discriminates against alternatively spliced exons. (1993) (27)
Coma and axonal degeneration in vitamin B12 deficiency. (1980) (27)
Tau immunization: a cautionary tale? (2015) (26)
The molecular and cellular pathology of Alzheimer neurofibrillary lesions. (1989) (24)
Regulation of AMPA receptor trafficking by δ-catenin (2008) (24)
Evolution of New miRNAs and Cerebro-Cortical Development. (2018) (24)
Cognitive Decline in Patients with Familial Alzheimer's Disease Associated with E280a Presenilin-1 Mutation: A Longitudinal Study (2000) (22)
Presenilin affects arm/beta-catenin localization and function in Drosophila. (2000) (22)
Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. (2017) (22)
Staged miRNA re-regulation patterns during reprogramming (2013) (22)
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains (2009) (22)
β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice (2016) (21)
Brain microtubule associated proteins : modifications in disease (1997) (21)
Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr) (2019) (21)
Beyond phrenology, at last (2003) (20)
iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases (2017) (20)
Exploratory data from complete genomes of familial alzheimer disease age‐at‐onset outliers (2012) (20)
Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs (2015) (20)
COVID-19 in older people with cognitive impairment in Latin America (2020) (19)
Liquid–liquid phase separation of Tau by self and complex coacervation (2021) (19)
Reconstructing ancestral genome content based on symmetrical best alignments and Dollo parsimony (2008) (19)
Axonal transport of cytoskeletal proteins in aluminum toxicity. Aluminum toxicity and axonal transport. (1983) (18)
Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation (2015) (18)
Senile Plaques Are Located Between Apical Dendritic Clusters (1987) (18)
Characterization of Postmortem Human Brain Proteins by Two‐Dimensional Gel Electrophoresis (1982) (18)
Thrombotic stroke associated with elevated plasma factor VIII (1980) (18)
A microRNA-mRNA expression network during oral siphon regeneration in Ciona (2017) (17)
A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein To Facilitate the Detection of SARS-CoV-2 (2020) (17)
Functional neuronal circuitry and oscillatory dynamics in human brain organoids (2022) (16)
MEA Viewer: A high-performance interactive application for visualizing electrophysiological data (2017) (16)
Tau protein and neurodegeneration (1990) (16)
Detection of Prokaryotic Genes in the Amphimedon queenslandica Genome (2016) (16)
Morphometric image analysis of neuropil threads in alzheimer's disease (1993) (15)
Fast motif discovery in short sequences (2016) (15)
Personalized medicine for effective Alzheimer disease treatment. (2015) (15)
Alzheimer’s Disease: Lessons from Cell Biology (2011) (15)
A possible fetal antigen ofM r70,000 in neurofibrillary tangles (1991) (15)
Discovery of compounds that will prevent tau pathology (2002) (14)
Action potential propagation recorded from single axonal arbors using multielectrode arrays. (2018) (14)
Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology (2010) (14)
The impact of SARS‐CoV‐2 in dementia across Latin America: A call for an urgent regional plan and coordinated response (2020) (13)
High molecular weight microtubule‐associated proteins: Purification by electro‐elution and amino acid compositions (1986) (13)
Cellular Signaling Pathways and Cytoskeletal Organization (1996) (12)
Diseases: Study neuron networks to tackle Alzheimer's (2013) (12)
Development of an Assay to Screen for Inhibitors of Tau Phosphorylation by Cdk5 (2004) (12)
The Neuritic Dystrophy of Alzheimer’s Disease: Degeneration or Regeneration? (1991) (11)
Control over single-cell distribution of G1 lengths by WNT governs pluripotency (2019) (11)
The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation (2017) (11)
Secreted beta-APP stimulates MAP kinase and phosphorylation of tau in neurons. (1995) (11)
Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Screening Using Reverse Transcriptase–Quantitative Polymerase Chain Reaction or CRISPR-Based Assays in Asymptomatic College Students (2021) (11)
A notable cleavage: winding up with beta-amyloid. (1999) (10)
Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP (2004) (10)
Apolipoprotein E ε 4 Modifies Alzheimer ’ s Disease Onset in an E 280 A PS 1 Kindred (2003) (9)
Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate (2022) (9)
A Model for Local Regulation of Translation Near Active Synapses (2005) (9)
Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia (2022) (9)
A path toward understanding neurodegeneration (2016) (9)
Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease. (1990) (9)
Presenilin 1 interaction in the brain with a novel member of the Armadillo family. (1997) (9)
Microtubule-associated Protein 2 c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280 – deficient Melanoma Cell Line (1997) (8)
Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol (2022) (8)
iPSCs-derived nerve-like cells from familial Alzheimer’s disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome (2019) (7)
Cellular aspects of Alzheimer neurofibrillary pathology. (1992) (7)
Presenilin Interactions and Alzheimer's Disease (1998) (7)
Recording action potential propagation in single axons using multi-electrode arrays (2017) (7)
Intrinsic network activity in human brain organoids (2021) (7)
Tamoxifen Inhibits CDK 5 Kinase Activity by Interacting with p 35 / p 25 and Modulates the Pattern of Tau Phosphorylation Graphical (2015) (7)
Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation (2022) (7)
Rapid CRISPR-based surveillance of SARS-CoV-2 in asymptomatic college students captures the leading edge of a community-wide outbreak (2020) (6)
LRP1 is a master regulator of tau uptake and spread (2020) (6)
Non-contact monitoring of extra-cellular field potentials with a multi-electrode array. (2019) (6)
Retinoic Acid Induces MAP‐2‐Containing Neurites in Mouse Neuroblastoma Cells (1986) (6)
Specific microRNAs modulate ES cell-derived neurogenesis (2005) (6)
Traveling the tau pathway: a personal account. (2006) (6)
IMMUNE ELECTRON MICROSCOPY OF PAIRED HELICAL FILAMENTS (PHF) WITH TAU ANTIBODIES: 132 (1987) (5)
f-divergence cutoff index to simultaneously identify differential expression in the integrated transcriptome and proteome (2016) (5)
Tau Condensates. (2019) (5)
TAU-SPECIFIC MONOCLONAL AND POLYCLONAL ANTIBODIES SUGGEST THAT TAU IS A MAJOR ANTIGENIC COMPONENT OF ALZHEIMER NEUROFIBRILLARY TANGLES (NFT) (1986) (5)
Patterns of neuronal Rhes as a novel hallmark of tauopathies (2021) (5)
Neural Development Under Conditions of Spaceflight (2003) (4)
TAU PROTEIN IS INTEGRATED INTO PAIRED HELICAL FILAMENTS (PHF) IN ALZHEIMERʼS DISEASE (AD) (1986) (4)
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy (2021) (4)
Extracellular detection of neuronal coupling (2021) (4)
Development of a fluorescent high throughput assay for tau aggregation. (2004) (4)
CRISPR-based and RT-qPCR surveillance of SARS-CoV-2 in asymptomatic individuals uncovers a shift in viral prevalence among a university population (2020) (3)
Self-organized morphogenesis of a human neural tube in vitro by geometric constraints (2021) (3)
Process formation in Sf 9 cells induced by the expression of a microtubule-associated protein 2 C-like construct (2005) (3)
When someone you love has Alzheimer's : the caregiver's journey (1996) (3)
Corrections to "Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS"[Neuron 86, 1215-1227; June 3, 2015] (2016) (3)
Ubiquitination of a Novel form of α-Synuclein by Parkin (2002) (3)
Human brain organoid networks (2021) (3)
Alzheimer's Disease: a Cell Biological Perspective (1992) (3)
Type II CaS /calmodulin-dependent kinase phosphorylates tau protein in the region of the mouse repeat (1987) (3)
Neuroscience gears up for duel on the issue of brain versus deity (2006) (3)
PhDs: what's left if science abdicates? (2011) (3)
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS (2016) (3)
Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles (1987) (2)
Neurolab: learning how the nervous system adapts to microgravity. (1998) (2)
From the laboratory (1987) (2)
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development (2018) (2)
Tracking Down Mutations Cell by Cell (2016) (2)
The miRNA System: Bifurcation Points of Cancer and Neurodegeneration (2011) (2)
Pyramidal Cell Topography of Microtubule‐Associated Proteins and Their Precipitation into Paired Helical Filaments (1989) (2)
miR-142-3p Regulates Cortical Oligodendrocyte Gene Co-expression Networks Associated with Tauopathy. (2021) (2)
Interaction between parkin and alpha‐synuclein (2008) (2)
An Ethical Context For Presymptomatic Testing in Alzheimer’s Disease (2000) (2)
Mislocalization and clearance of neuronal Rhes as a novel hallmark of tauopathies (2020) (2)
Cell Population Effects in a Mouse Tauopathy Model Identified by Single Cell Sequencing (2019) (2)
DYSTROPHIC NEURITES IN THE NEOCORTEX ARE THE CRITICAL NEUROPATHOLOGICAL CORRELATE OF DEMENTIA IN ALZHEIMERʼS DISEASE: 225 (1990) (2)
A partnership that delivers (1999) (2)
Language after bilateral cerebral infarctions (1980) (2)
Use of a Neural Circuit Probe to Validate in silico Predictions of Inhibitory Connections (2017) (2)
Genetic testing must recognize impact of bad news on recipient (2008) (2)
ELECTRON MICROSCOPIC LOCALIZATION OF TAU IN ALZHEIMER NFT AND PHF.: 6 (1987) (2)
The high flying genome. (2001) (1)
W5: A NATURAL HISTORY OF ALZHEIMER'S DISEASE: PATH-DEPENDENT EVALUATION OF CLINICAL AND ECONOMIC OUTCOMES USING DECISION DATABASE METHODOLOGY (1999) (1)
Possible modifications of vimentin following acquisition of triton insolubility. (1984) (1)
Profiling the microRNAs (2010) (1)
Tau-er of Power (2015) (1)
Age-associated trajectories of biomarkers in early-onset Alzheimer's disease, for the Alzheimer's Prevention Initiative (2012) (1)
Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions (2012) (1)
Staged miRNA re-regulation patterns during reprogramming (2013) (1)
Phosphorylated baculovirus p 10 is a heat-stable microtubule-associated protein associated with process formation in Sf 9 cells (2005) (1)
Enhanced neuronal regeneration in the CAST/Ei mouse strain is linked to expression of differentiation markers after injury (2017) (1)
Colocalization of Parkin with α-Synuclein in the Lewy Bodies of Parkinson Disease (2002) (1)
Statistical analysis of dendritic spine distributions in rat hippocampal cultures (2013) (1)
Better read than dread (1992) (1)
Antisense inhibition of protein synthesis and function : rabbit retinal protein. (1996) (1)
Elevated cerebrospinal fluid amyloid-Beta42 levels in young adults at genetic risk for early-onset alzheimer's disease (2011) (1)
ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells (2023) (1)
CAREGIVING, EMPATHY, AND ALZHEIMER’S DISEASE (2017) (1)
Cloning of Neurofibrillary Tangle-Related Genes (1987) (1)
The Long Reach of Evolution and Development: Effects on the Alzheimer Brain (2000) (1)
Reply to the “Letter to the Editors” by Steven Buyske (2009) (1)
Linking Amyloid Precursor Protein Processing and Tau-Related Pathology in Alzheimer’s Disease (1995) (1)
Yoga Improves Older Adults’ Affective Functioning and Resting-state Brain Connectivity: Evidence from a Pilot Study (2021) (1)
Powrot na Palawan (2004) (0)
protein 2:Monoclonal antibodies demonstrate theselective incorporation ofcertain epitopes intoAlzheimer neurofibrillary tangles (1984) (0)
Enhancing the Interpretation of Genomic Data Using RNA-Seq from iPS-Derived Neurons (2012) (0)
Alzheimer's disease: too broad a perspective? (1998) (0)
Reply (1981) (0)
Book ReviewAlzheimer's Disease and Related Disorders: Research and management (1984) (0)
ING Parallel Discovery of Alzheimer ’ s Therapeutics (2014) (0)
SEQUENCE OF A HUMAN MAP2 cDNA WHICH CONTAINS AN EPITOPE SHARED WITH THE ALZHEIMER NEUROFIBRILLARY TANGLE (NFT): 136 (1987) (0)
Antisense-Based Technologies and Insights in Neurobiology (1993) (0)
Mapping Phase Diagram of Tau-RNA LLPS Under Live Cell Coculturing Conditions. (2023) (0)
SUMO2 Protects Against Tau-induced Synaptic and Cognitive Dysfunction (2022) (0)
A New Tool for Local Manipulation of Neuronal Micro-Circuitry with Ions and Force (2017) (0)
Studies of the PS-1 pedigree from Columbia (2000) (0)
Coordinated Regulation of Synaptic Plasticity by microRNAs (2010) (0)
Studies of the Beta-Amyloid Precursor Protein in Brain and the Pathological Transformation of Tau into the Neurofibrillary Tangle (1988) (0)
Farnesyl Transferase Inhibition for the Treatment of Tauopathies (2018) (0)
Automated detection of extracellular action potentials from single neurons (2022) (0)
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) (2018) (0)
Identification of Genes that Modify the Age of Onset in a Large Familial Alzheimer's Disease Kindred (2005) (0)
Frontispiece: Particle Display: A Quantitative Screening Method for Generating High‐Affinity Aptamers (2014) (0)
AMYLOID-B-PEPTIDE ACTIVATES THE NEURONAL c-AbL TYROSINE KINASE/p73 SIGNALING PATHWAY (2005) (0)
A Deep Learning Framework for Classification of in vitro Multi-Electrode Array Recordings (2019) (0)
Tau protein the of a n axonal morphology (1991) (0)
Human stem cells cultured in NM23-H1-MM over anti-MUC1* antibody surfaces express higher levels of naïve markers and lower levels of primed markers. (2013) (0)
A Novel Gene in the Armadillo Family Interacts with Presenilin 1 (1998) (0)
In situ lipid metabolism characterization in cells and brain organoids by optical photothermal infrared microscopy (Conference Presentation) (2023) (0)
DISCOVERY OF NOVEL SMALL MOLECULE THERAPEUTICS FOR ALZHIEMER'S DISEASE BY TARGETING STERIC ZIPPERS INVOLVED IN TAU AGGREGATION (2019) (0)
S4-03-05 Signal transduction (2006) (0)
THE AMINO ACID SEQUENCE OF PAIRED HELICAL FILAMENTS CORRESPONDS TO A FETAL TAU mRNA: 159 (1989) (0)
Introduction (1992) (0)
Outsmarting Alzheimer's (2015) (0)
Alzheimer research forum live discussion: non-coding RNAs in neurodegeneration. (2009) (0)
Alzheimer's Disease in Twins (1981) (0)
RNA Interference Technology: miRNAs in the brain and the application of RNAi to neurons (2005) (0)
Book ReviewThe Management of Acute Stroke (1989) (0)
δ-Catenin, Presenilin, and the Synaptic-Adherens Junction Complex (2002) (0)
In vitro validation of in silico identified inhibitory interactions (2019) (0)
Probes for the Molecular Components of Plaques and Tangles Point to a Broadening View of Alzheimer Pathology (1989) (0)
Alzheimer's disease: Which way is forward? (1994) (0)
The Lonafarnib target, Rhes, is uniquely dysregulated in tauopathies: A human postmortem study (2021) (0)
Studies on the Analysis of Brain Structural Proteins by Chromatofocusing (1985) (0)
Calcineurin localization at the growing tips of neurites depends upon intact cytoskeletal components (1992) (0)
EPITOPE-SPECIFIC STAINING PATTERNS OF TAU IMMUNOREACTIVITY IN DOWNʼS ALZHEIMERʼS DISEASE: 161 (1989) (0)
The Fortune Teller (1999) (0)
CREST, a Cas13‐Based, Rugged, Equitable, Scalable Testing (CREST) for SARS‐CoV‐2 Detection in Patient Samples (2022) (0)
Authors' response to commentary (1995) (0)
Another Tau Mutation, Another Insight (2004) (0)
INCREASED RATE OF ACCUMULATION OF CHAT PROXIMAL TO A SCIATIC NERVE LIGATURE IN A13+-TREATED RABBITS: 61 (1982) (0)
OverexpressionofTau inaNonneuronal Cell InducesLong CellularProcesses (1991) (0)
Secreted 1-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances Xs phosphorylation (0)
Synaptic dysregulation in a human iPSC model of major mental disorders (2014) (0)
USING AN ADAS-COG CALIBRATED QUANTITATIVE SYSTEMS PHARMACOLOGY NEURONAL NETWORK MODEL TO EXPLORE THE IMPACT OF A TAU MUTATION ON ACTION POTENTIAL PROPAGATION (2019) (0)
Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs (2015) (0)
Cell biology in support of neurological research: 2018 highlights (2019) (0)
LOSS-OF-FUNCTION CODING AND NON-CODING VARIANTS IN TET2 ARE ASSOCIATED WITH NEURODEGENERATIVE DISEASES (2019) (0)
The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation (2017) (0)
microRNAs at the synapse (2010) (0)
Function of MicroRNA-145 in Human Embryonic Stem Cell Pluripotency (2011) (0)
Title Human iPSC-Derived Neuronal Model of TauA 152 T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability Permalink (0)
Tau Immunostaining in Alzheimer's Disease and Other Neurodegenerative Disorders (1987) (0)
Posttranscriptional Regulation in Nervous System Development and Plasticity (2010) (0)

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