Kent Vrana

Q: What Schools Are Affiliated With Kent Vrana

Kent Vrana is affiliated with the following schools: Wake Forest University, Louisiana State University, Pennsylvania State University, University of Colorado, West Virginia University, University of Iowa

Kent Vrana's AcademicInfluence.com Rankings

Kent Vrana

Medical

#2069

World Rank

#2467

Historical Rank

#439

USA Rank

Pharmacology

#287

World Rank

#336

Historical Rank

#37

USA Rank

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Why Is Kent Vrana Influential?

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According to Wikipedia, Kent Eugene Vrana is an American pharmacologist. He was born in Lincoln, Nebraska, and attended Thomas Jefferson High School in Council Bluffs, Iowa. Vrana then enrolled at the University of Iowa, where he studied biochemistry, graduating in 1978. He pursued a doctorate in the subject from the Louisiana State University Medical Center, completing graduate study in 1983, followed by postdoctoral study at the Carnegie Institution of Washington. Vrana began teaching at West Virginia University in 1986 as an assistant professor. He left for the Wake Forest University School of Medicine in 1991, and became a full professor in 2001. Vrana was named chair of the Department of Pharmacology at the Milton S. Hersey Medical Center at Penn State in 2004 after Elliot Vesell stepped down. He concurrently holds the Elliot S. Vesell professorship at the Pennsylvania State University College of Medicine, and serves as the founding Director of the Pennsylvania-designated Medical Marijuana Academic Clinical Research Center at Penn State.

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Kent Vrana's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Quantitative RT-PCR: pitfalls and potential. (1999) (1172)
Twenty-five years of quantitative PCR for gene expression analysis. (2008) (1139)
Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression (1996) (692)
Cytotoxic and genotoxic potential of dopamine (1999) (448)
Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit. (1982) (326)
Parthenogenetic Stem Cells in Nonhuman Primates (2002) (315)
Manganese uptake and distribution in the central nervous system (CNS). (1999) (194)
Nonhuman primate parthenogenetic stem cells (2003) (193)
Tyrosinase mRNA is expressed in human substantia nigra. (1997) (184)
Fundamentals of DNA hybridization arrays for gene expression analysis. (2000) (181)
Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase (1998) (169)
Circulating Cytokines as Biomarkers of Alcohol Abuse and Alcoholism (2010) (168)
Nitration and Inactivation of Tyrosine Hydroxylase by Peroxynitrite* (2001) (147)
Chronic cocaine‐mediated changes in non‐human primate nucleus accumbens gene expression (2001) (121)
Persistent Alterations in Mesolimbic Gene Expression with Abstinence from Cocaine Self-Administration (2008) (117)
Chronic Cocaine Administration Increases CNS Tyrosine Hydroxylase Enzyme Activity and mRNA Levels and Tryptophan Hydroxylase Enzyme Activity Levels (1993) (115)
Complex molecular regulation of tyrosine hydroxylase (2014) (98)
Manganese-induced cytotoxicity in dopamine-producing cells. (2004) (96)
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by l-BSO and apoptosis (2000) (89)
Multivariate Analysis of Laminar Patterns of Neurodegeneration in Posterior Cingulate Cortex in Alzheimer's Disease (1998) (73)
Cocaine-responsive gene expression changes in rat hippocampus (2001) (72)
Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology. (2003) (68)
Differential Gene Expression in Tamoxifen-Resistant Breast Cancer Cells Revealed by a New Analytical Model of RNA-Seq Data (2012) (65)
Advances in the molecular characterization of tryptophan hydroxylase (1998) (60)
The Pharmacological Case for Cannabigerol (2020) (58)
Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration (2010) (58)
Review article: the many potential roles of intestinal serotonin (5‐hydroxytryptamine, 5‐HT) signalling in inflammatory bowel disease (2017) (58)
Changes in rat frontal cortex gene expression following chronic cocaine. (2002) (57)
Use of microarray technologies in toxicology research. (2003) (56)
Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints. (2002) (55)
A Carboxyl Terminal Leucine Zipper Is Required for Tyrosine Hydroxylase Tetramer Formation (1994) (55)
Transcriptome analysis of frontal cortex in alcohol‐preferring and nonpreferring rats (2005) (54)
T lineage differentiation from induced pluripotent stem cells. (2009) (53)
Robust activation of the human but not mouse telomerase gene during the induction of pluripotency (2010) (51)
SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. (2010) (49)
Embryonic stem cells from parthenotes. (2006) (49)
Functional Domains of Human Tryptophan Hydroxylase 2 (hTPH2)* (2006) (46)
Inhibition of tryptophan hydroxylase activity and decreased 5‐HT1A receptor binding in a mouse model of Huntington's disease (2002) (45)
Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior (2008) (45)
Effects of the Probiotic Formulation VSL#3 on Colitis in Weanling Rats (2007) (43)
Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity. (2002) (42)
Gene expression changes following extinction testing in a heroin behavioral incubation model (2009) (41)
Amino‐Terminal Analysis of Tryptophan Hydroxylase: Protein Kinase Phosphorylation Occurs at Serine‐58 (1997) (39)
Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling. (2000) (39)
Tyrosine Hydroxylase Activation and Inactivation by Protein Phosphorylation Conditions (1981) (39)
Radioenzymatic assay for tryptophan hydroxylase: [3H]H2O release assessed by charcoal adsorption (1993) (39)
Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells (2008) (38)
Use of elevated reverse transcription reaction temperatures in RT-PCR. (1996) (36)
Correlating Human and Animal Studies of Cocaine Abuse and Gene Expression (2008) (36)
Repeated Cocaine Self-Administration Causes Multiple Changes in Rat Frontal Cortex Gene Expression (2002) (35)
Alcohol and gene expression in the central nervous system. (2005) (35)
Protein biomarkers of alcohol abuse (2012) (34)
Effects of vasopressin and elimination of corticotropin-releasing hormone-target cells on pro-opiomelanocortin mRNA levels and adrenocorticotropin secretion in ovine anterior pituitary cells. (1997) (32)
Tyrosinase enhances the covalent modification of DNA by dopamine. (1996) (32)
Regulation of Rat Dopamine Transporter mRNA and Protein by Chronic Cocaine Administration (1999) (32)
Catalytic core of rat tyrosine hydroxylase: terminal deletion analysis of bacterially expressed enzyme. (1994) (32)
Heroin self-administration: I. Incubation of goal-directed behavior in rats (2008) (31)
A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes (2007) (31)
Recombinant rabbit tryptophan hydroxylase is a substrate for cAMP-dependent protein kinase. (1994) (30)
Tyrosine Hydroxylase Inactivation Following cAMP‐Dependent Phosphorylation Activation (1983) (30)
TPH2 in the ventral tegmental area of the male rat brain (2011) (30)
Dopamine beta‐hydroxylase and its genetic variants in human health and disease (2020) (29)
Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders. (2010) (29)
Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions (2020) (29)
Associating schizophrenia, long non-coding RNAs and neurostructural dynamics (2015) (29)
Synthetic Cannabinoid Activity Against Colorectal Cancer Cells (2018) (27)
Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access (2016) (27)
Propagation of undifferentiated human embryonic stem cells with nano-liposomal ceramide. (2009) (27)
Leucine zippers and coiled-coils in the aromatic amino acid hydroxylases (1991) (27)
A retrospective chart review to identify perinatal factors associated with food allergies (2012) (27)
Creating a Virtual Pharmacology Curriculum in a Problem-Based Learning Environment: One Medical School’s Experience (2013) (27)
Extended cocaine self‐administration and deprivation produces region‐specific and time‐dependent changes in connexin36 expression in rat brain (2005) (26)
Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior? (2011) (26)
Application of quantitative RT-PCR to the analysis of dopamine receptor mRNA levels in rat striatum. (1995) (26)
Amphetamine withdrawal produces region‐specific and time‐dependent changes in connexin36 expression in rat brain (2005) (26)
A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques. (2012) (26)
Novel Immunotherapies for Hematological Malignancies. (2016) (25)
Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass (2008) (25)
Plasma Proteomics: A Noninvasive Window on Pathology and Pediatric Cardiac Surgery (2006) (25)
Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals (2022) (24)
Pituitary corticotroph function during the stress hyporesponsive period in neonatal rats. (1993) (24)
Exposure to environmental enrichment attenuates addiction-like behavior and alters molecular effects of heroin self-administration in rats (2018) (24)
Carboxyl terminal deletion analysis of tryptophan hydroxylase. (1997) (23)
Chronic selegiline administration transiently decreases tyrosine hydroxylase activity and mRNA in the rat nigrostriatal pathway. (1992) (23)
A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope (2002) (23)
Classification of Alcohol Abuse by Plasma Protein Biomarkers (2010) (22)
Persistent proteomic alterations in the medial prefrontal cortex with abstinence from cocaine self‐administration (2009) (22)
Dual-Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass (2010) (22)
Paracrine Interactions within the Pituitary Gland (1998) (22)
Human embryonic and mesenchymal stem cells express different nuclear proteomes. (2009) (21)
Depletion of abundant proteins from non‐human primate serum for biomarker studies (2006) (20)
Boosting serotonin in the brain: is it time to revamp the treatment of depression? (2012) (19)
Parthenogenetic Stem Cells (2006) (19)
Anticipation of Personal Genomics Data Enhances Interest and Learning Environment in Genomics and Molecular Biology Undergraduate Courses (2015) (19)
Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration. (2006) (19)
p‐Ethynylphenylalanine (2000) (18)
PCR-based apolipoprotein E genotype analysis from archival fixed brain (1998) (17)
Adrenocorticotropin and corticosterone levels in pre-weanling spontaneously hypertensive rats. (1989) (17)
Manganese in Health and Disease: From Transport to Neurotoxicity (2001) (17)
Cannabidiol (CBD) Oil Does Not Display an Entourage Effect in Reducing Cancer Cell Viability in vitro (2020) (16)
The use of neuroproteomics in drug abuse research. (2010) (16)
Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture-Healing: A Preliminary Investigation. (2014) (16)
Nuclear proteomics and directed differentiation of embryonic stem cells. (2007) (15)
A chimeric tyrosine/tryptophan hydroxylase. The tyrosine hydroxylase regulatory domain serves to stabilize enzyme activity. (1997) (14)
Glucocorticoids plus opioids up-regulate genes that influence neuronal function (2007) (14)
Reward devaluation and heroin escalation is associated with differential expression of CRF signaling genes (2016) (14)
Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease Phenotype (2018) (13)
Advancing technologies in gene amplification. (1996) (13)
Paraoxon-induced decrease in the muscarinic acetylcholine receptor content in rat heart. (1987) (13)
The future of proteomics in the study of alcoholism. (2004) (13)
Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions (2021) (13)
Enhanced nuclear proteomics (2008) (13)
Elsevier's integrated review pharmacology (2012) (13)
Semiquantitative real-time PCR for analysis of mRNA levels. (2003) (13)
Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. (2011) (12)
Inactivation of tyrosine hydroxylase by pterin substrates following phosphorylation by cyclic AMP-dependent protein kinase. (1990) (12)
Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain. (1995) (11)
Involvement of ecto-phosphoryl transfer in contractions of the smooth muscle of the guinea pig vas deferens to adenosine 5'-triphosphate. (1991) (11)
Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats. (2020) (11)
2‐D DIGE identification of differentially expressed heterogeneous nuclear ribonucleoproteins and transcription factors during neural differentiation of human embryonic stem cells (2009) (11)
Δ8-THC: Legal Status, Widespread Availability, and Safety Concerns. (2021) (11)
Pediatric cardiopulmonary bypass circuits: a review of studies conducted at the Penn State Pediatric Cardiac Research Laboratories. (2009) (11)
Intersubunit binding domains within tyrosine hydroxylase and tryptophan hydroxylase (2000) (10)
The influence of voltage‐gated sodium channels on human gastrointestinal nociception (2018) (10)
An Interactive Database of Cocaine-Responsive Gene Expression (2002) (10)
Validation of the Obsessive Compulsive Drug Use Scale (OCDUS) Among Male Heroin Addicts in China (2016) (8)
Expression of preproNPY and precursor VIP mRNAs in rats under hypo- or hyperthyroid conditions (1992) (8)
Development of a Bioassay for Pulmonary Cell Production of Fibrogenic Factors (1991) (7)
Multifocal Cortical Neurodegeneration in Alzheimer’s Disease (1999) (7)
Reptin52 expression during in vitro neural differentiation of human embryonic stem cells (2009) (7)
High efficiency transient expression of eukaryotic genes: use of an HSV-1 immediate early promoter (ICP4). (1990) (7)
How the regulatory and catalytic domains get together (1999) (7)
A chimeric tyrosine/tryptophan hydroxylase (1997) (7)
Influence of Parental Monitoring, Sensation Seeking, Expected Social Benefits, and Refusal Efficacy on Tobacco and Alcohol Use in Chinese Adolescents (2016) (6)
Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy‐induced peripheral neuropathy (2022) (6)
Tyrosine hydroxylase and tryptophan hydroxylase do not form heterotetramers (1998) (6)
Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin seeking behavior in rats (2019) (5)
AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. (1995) (5)
Evaluating the Antinociceptive Efficacy of Cannabidiol Alone or in Combination with Morphine Using the Formalin Test in Male and Female Mice. (2021) (5)
Cannabis and Cannabis Derivatives for Abdominal Pain Management in Inflammatory Bowel Disease (2021) (5)
A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway (2000) (5)
Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2 (2014) (5)
Dopamine Covalently Modifies DNA in a Tyrosinase-Enhanced Manner (1996) (5)
Penn State Hershey--center for pediatric cardiovascular research. (2009) (4)
Impact of the NaV1.8 variant, A1073V, on post-sigmoidectomy pain and electrophysiological function in rat sympathetic neurons. (2019) (4)
Stem cell biology should be taught in high schools. (2007) (4)
Identification of amino-terminal sequences contributing to tryptophan hydroxylase tetramer formation (1999) (4)
Inhibition of Sphingosine Kinase Activity Enhances Immunogenic Cell Surface Exposure of Calreticulin Induced by the Synthetic Cannabinoid 5-epi-CP-55,940. (2021) (4)
Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse. (2001) (4)
Trigeminal neuronal recording in animal models of orofacial pain. (2004) (3)
Polysubstance use in inflammatory bowel disease (2021) (3)
Rescuing Suboptimal Patient-Reported Outcome Instrument Data in Clinical Trials: A New Strategy (2018) (3)
The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease. (2016) (3)
Gender‐specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen‐1 knockout mice (2012) (3)
A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme (2019) (3)
An RNA-seq study of the mPFC of rats with different addiction phenotypes (2022) (2)
The application of RT-PCR techniques to the analysis of mRNA in tissue and single cells. (1998) (2)
The Rise and Risk of Delta-8 THC (Delta-8-Tetrahydrocannabinol) (2022) (2)
Secondary Terpenes in Cannabis sativa L.: Synthesis and Synergy (2022) (2)
Opinion: Celebrating R and D expenditures badly misses the point (2015) (2)
Emerging techniques in biomedical research and their application to alcohol toxicity. (2003) (2)
Combinations of Cannabidiol and Δ9-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain (2022) (2)
Enzyme Activity: Control (2007) (2)
Acute Cannabigerol Administration Lowers Blood Pressure in Mice (2022) (2)
CNS Genes Implicated in Relapse (2008) (2)
Acidosis-induced metallothionein (MT) mRNA expression in neonatal rat primary astrocyte cultures. (1998) (2)
Emerging molecular approaches in stem cell biology. (2009) (2)
Systematic screening of gene expression using a cDNA macroarray. (2003) (1)
Comprar Elsevier's Integrated Review Pharmacology, 2nd Edition | Mark Kester | 9780323074452 | Saunders (2011) (1)
Erratum: Nonhuman primate parthenogenetic stem cells (Proceedings of the National Academy of Sciences of the United States of America (September 30, 2003) 100:1 (11911-11916)) (2004) (1)
Symptoms and Extraintestinal Manifestations in Active Cannabis Users with Inflammatory Bowel Disease. (2021) (1)
NUCLEIC ACIDS | Extraction (2000) (1)
A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway. (2000) (1)
Cannabinoid Hyperemesis Syndrome and Hypophosphatemia in Adolescents (2022) (1)
Greater avoidance of a saccharin cue paired with passive delivery of heroin is associated with a select increase in expression of CRFR2 and CRFbp in the hippocampus in rats (2022) (1)
Molecular Studies by Chimeragenesis and Mutagenesis (2002) (1)
Treatment of Infectious Diseases (2007) (1)
Caveat Emptor: Single Nucleotide Polymorphism Reporting in Pharmacogenomics (2013) (1)
Distinctive Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis. (2022) (0)
Video Introduction for a PBL Case of Autoimmune Thrombocytopenic Purpura (2012) (0)
Effects of cannabidiol with and without other cannabinoids and terpenes on short-term and long-term stress-related behaviors (2022) (0)
THE PHARMACOLOGICAL CASE FOR CANNABIGEROL (CBG) (2020) (0)
Environmental enrichment augments behavioral and epigenetic response to heroin self‐administration (2016) (0)
Subject Index Vol. 57, 1993 (1993) (0)
Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression: Correction (2001) (0)
Panning for molecular gold (1999) (0)
Obsessive Compulsive Drug Use Scale--Chinese Version (2020) (0)
Su2033 - Genetic Polymorphism in Dopamine Beta Hydroxylase Gene is Associated with Inflammatory Bowel Disease (2018) (0)
Homology-based Theoretical Molecular Model of Human Tryptophan Hydroxylase Regulatory, Catalytic and Tetramerization Domains (2001) (0)
CANNabinoid Drug Interaction Review (CANN-DIR™) (2023) (0)
Functional genomics of toxicant exposure Multiplex DNA hybridization arrays in neurotoxicology research (2001) (0)
Research report C in rat frontal cortex gene expression following chronic (2002) (0)
Contents (2019) (0)
Contents Vol. 100, 2017 (2017) (0)
Cannabinoids as Potential Cancer Therapeutics: The Concentration Conundrum. (2023) (0)
DISTINCTIVE THERAPEUTIC EFFECTS OF NON-EUPHORIGENIC HEMP EXTRACTS IN OSTEOARTHRITIS (2022) (0)
642 - SCN10A SNP RS6795970 (G>A) Associated with Silent Inflammatory Bowel Disease Phenotype (2018) (0)
Minireview The Pharmacological Case for Cannabigerol (2021) (0)
Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019. (2019) (0)
Differentially Regulated Proteins in the Vitreous of Horses with Equine Recurrent Uveitis ( ERU ) and Eye Healthy Controls (2005) (0)
"Making it real" time. (2013) (0)
REVIEW ALCOHOL AND GENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEM (2005) (0)
Efficient Synthesis for Altering Side Chain Length on Cannabinoid Molecules and Their Effects in Chemotherapy and Chemotherapeutic Induced Neuropathic Pain (2022) (0)
Effects Of Cannabis Extracts On Pain And Ptoa Progression In Mice, Involvement Of Entourage And Sex-Dependent Effects (2023) (0)
Library Screening and Preliminary Characterization of Synthetic Cannabinoids Against Prostate and Pancreatic Cancer Cell Lines. (2023) (0)
Acute Cannabigerol Administration Lowers Blood Pressure in Mice (2022) (0)
Bioinformatic and computational approaches for analysis of genomics data in neurotoxicology research (2016) (0)
Chemical Perspective on Neurotransmission and Drug Discovery for the Central Nervous System (2010) (0)
Experimental Design for Hybridization Array Analysis of Gene Expression (2001) (0)
Whole proteome mapping of compound-protein interactions (2022) (0)
118 – cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches (2004) (0)
An experimental protocol for a double-blind placebo-controlled evaluation of the effectiveness of oral naltrexone in management of adolescent eating disorders. (2022) (0)
Potential Role for Lactic Acid Bacteria in Immune Modulation (2012) (0)
article : the many potential roles of intestinal serotonin ( 5-hydroxytryptamine , 5-HT ) signalling in inflammatory bowel disease (0)
Functional genomics of cocaine in non-human primates and rats (2000) (0)
TYROSINE HYDROXYLASE ACTIVITY AND mRNA CHANGES IN HUNTINGTON'S DISEASE (2008) (0)
M2 binding and m2 receptors in experimental monkey neocortex (1997) (0)
Acknowledgement to referees 2013 (2014) (0)
Functional genomic analysis in pain research using hybridization arrays. (2004) (0)
Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson's Disease. (2015) (0)

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Other Resources About Kent Vrana

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What Schools Are Affiliated With Kent Vrana?

Kent Vrana is affiliated with the following schools: