Kevan Shokat

Q: What Schools Are Affiliated With Kevan Shokat

Kevan Shokat is affiliated with the following schools: University of California, Berkeley, Reed College, Princeton University, Stanford University, Semmelweis University, University of California, San Francisco

Kevan Shokat's AcademicInfluence.com Rankings

Kevan Shokat

Biology

#4083

World Rank

#6140

Historical Rank

#1590

USA Rank

Biochemistry

#475

World Rank

#559

Historical Rank

#170

USA Rank

biology Degrees

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Biology

Kevan Shokat's Degrees

PhD Chemistry University of California, Berkeley

Why Is Kevan Shokat Influential?

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According to Wikipedia, Kevan Michael Shokat is an American chemical biologist. He is a Professor and chair in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco, a professor in the Department of Chemistry at University of California, Berkeley, and an Investigator with the Howard Hughes Medical Institute.

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Kevan Shokat's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing (2020) (3012)
RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF (2010) (1625)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions (2013) (1455)
IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response (2007) (1265)
The translational landscape of mTOR signalling steers cancer initiation and metastasis (2012) (1141)
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 (2009) (1124)
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling (2006) (1083)
A chemical switch for inhibitor-sensitive alleles of any protein kinase (2000) (1035)
The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal molecule (2001) (992)
Targets of the cyclin-dependent kinase Cdk1 (2003) (976)
Escape from HER family tyrosine kinase inhibitor therapy by the kinase inactive HER3 (2007) (969)
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR (2008) (838)
The Global Phosphorylation Landscape of SARS-CoV-2 Infection (2020) (651)
Targeting the cancer kinome through polypharmacology (2010) (619)
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. (2006) (618)
Features of selective kinase inhibitors. (2005) (604)
The unfolded protein response signals through high-order assembly of Ire1 (2009) (597)
Drugging the 'undruggable' cancer targets (2017) (477)
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. (2010) (468)
Rewiring of Genetic Networks in Response to DNA Damage (2010) (458)
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing (2020) (456)
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms (2020) (444)
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. (1997) (421)
Antigen-induced B-cell death and elimination during germinal-centre immune responses (1995) (404)
Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases (2008) (383)
Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors (2005) (379)
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design (2016) (375)
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. (2009) (372)
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells (1994) (365)
Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. (2006) (364)
The Site-Specific Installation of Methyl-Lysine Analogs into Recombinant Histones (2007) (350)
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores (2006) (343)
Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation (2009) (331)
A Chemical-Genetic Strategy Implicates Myosin-1c in Adaptation by Hair Cells (2002) (328)
Chemical genetic analysis of the time course of signal transduction by JNK. (2006) (326)
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma (2010) (309)
Discovery of nitrate–CPK–NLP signalling in central nutrient–growth networks (2017) (308)
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology (2012) (306)
The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. (2011) (304)
Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast (2010) (302)
Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor (2016) (300)
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates (2008) (297)
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation (2001) (296)
TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II (2009) (294)
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II (2012) (292)
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. (2003) (290)
Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma (2010) (290)
Inhibitor Hijacking of Akt Activation (2009) (282)
A semisynthetic epitope for kinase substrates (2007) (279)
Functional Organization of the S. cerevisiae Phosphorylation Network (2009) (271)
A surface on the androgen receptor that allosterically regulates coactivator binding (2007) (267)
Recognizing and exploiting differences between RNAi and small-molecule inhibitors. (2007) (265)
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells (2007) (259)
Bypassing a Kinase Activity with an ATP-Competitive Drug (2003) (256)
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer (2009) (254)
Structural basis for selective inhibition of Src family kinases by PP1. (1999) (251)
N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. (2016) (247)
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. (2007) (241)
Magic bullets for protein kinases. (2001) (238)
A Chemical-Genetic Approach to Studying Neurotrophin Signaling (2005) (237)
An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules (2005) (235)
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK (2011) (232)
Chemical Genetics: Where Genetics and Pharmacology Meet (2007) (228)
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure (2008) (227)
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. (2011) (223)
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. (2013) (223)
The Saccharomyces cerevisiae Mob2p–Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell–specific localization of Ace2p transcription factor (2002) (220)
Drugging MYCN through an allosteric transition in Aurora kinase A. (2014) (216)
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers (2013) (215)
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. (1996) (215)
A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1 (2013) (214)
Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling (2010) (211)
Design of allele-specific inhibitors to probe protein kinase signaling (1998) (211)
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. (2007) (207)
The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors (2009) (207)
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. (2013) (205)
Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species (2009) (204)
Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34 (2010) (203)
PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML (2008) (200)
Nuclear HuR accumulation through phosphorylation by Cdk1. (2008) (199)
Hierarchical modularity and the evolution of genetic interactomes across species. (2012) (198)
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A (2021) (197)
Two Cyclin-Dependent Kinases Promote RNA Polymerase II Transcription and Formation of the Scaffold Complex (2004) (194)
An integrated platform of genomic assays reveals small-molecule bioactivities. (2008) (193)
Phosphorylation of the Transcription Elongation Factor Spt5 by Yeast Bur1 Kinase Stimulates Recruitment of the PAF Complex (2009) (193)
PIKfyve Regulation of Endosome-Linked Pathways (2009) (191)
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. (2007) (189)
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin (2014) (188)
Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. (2007) (187)
EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma (2009) (184)
Engineering Src family protein kinases with unnatural nucleotide specificity. (1998) (181)
Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells (2009) (179)
The F Box Protein Dsg1/Mdm30 Is a Transcriptional Coactivator that Stimulates Gal4 Turnover and Cotranscriptional mRNA Processing (2005) (173)
PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. (2008) (169)
Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver (2010) (165)
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. (2003) (164)
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front (2006) (163)
Chemical-genomic dissection of the CTD code (2010) (162)
JNK2 is a positive regulator of the cJun transcription factor. (2006) (161)
Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain (2003) (160)
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. (2008) (156)
Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. (2009) (154)
Unnatural ligands for engineered proteins: new tools for chemical genetics. (2000) (150)
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. (2009) (148)
Suppression of p53-dependent senescence by the JNK signal transduction pathway (2007) (147)
A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. (1998) (144)
The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. (2005) (144)
Evolution of enhanced innate immune evasion by SARS-CoV-2 (2021) (144)
Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p (2000) (143)
Generation of Monospecific Nanomolar Tyrosine Kinase Inhibitors via a Chemical Genetic Approach (1999) (143)
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. (2004) (141)
A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. (2002) (140)
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. (2008) (138)
Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. (2015) (137)
Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. (2003) (135)
Phosphospecific proteolysis for mapping sites of protein phosphorylation (2003) (135)
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression (2009) (135)
Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways (2012) (135)
A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases (2005) (134)
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. (2008) (133)
Phosphatidylinositol 4-Kinase IIIβ Regulates the Transport of Ceramide between the Endoplasmic Reticulum and Golgi* (2006) (133)
Chemical genetic approaches for the elucidation of signaling pathways. (2001) (132)
Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition (2019) (129)
Identification of New JNK Substrate Using ATP Pocket Mutant JNK and a Corresponding ATP Analogue* (2001) (129)
Access Denied: Snf1 Activation Loop Phosphorylation Is Controlled by Availability of the Phosphorylated Threonine 210 to the PP1 Phosphatase* (2008) (129)
A new strategy for the generation of catalytic antibodies (1989) (127)
Chromophore-assisted light inactivation and self-organization of microtubules and motors. (1998) (127)
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation (2014) (127)
Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. (2010) (127)
Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response (2001) (123)
Combining chemical genetics and proteomics to identify protein kinase substrates. (2005) (123)
Chemically targeting the PI3K family. (2007) (121)
Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. (2016) (121)
Identification of Novel ERK2 Substrates through Use of an Engineered Kinase and ATP Analogs* (2003) (120)
Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase* (2008) (118)
Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors (2014) (118)
The emerging power of chemical genetics. (2002) (116)
Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development (2012) (116)
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages (2008) (116)
A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. (2017) (115)
Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis (2010) (114)
Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis (2007) (113)
Chemical Genetics Reveals a Role for Mps1 Kinase in Kinetochore Attachment during Mitosis (2005) (112)
Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors (2014) (110)
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 (2021) (109)
TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. (2009) (108)
IRE 1 Signaling Affects Cell Fate During the Unfolded Protein Response (2008) (106)
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition (2019) (106)
WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons (2015) (105)
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. (2008) (105)
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. (2013) (104)
Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K—mTOR pathway in pancreatic adenocarcinoma (2011) (104)
mTOR complex-2 activates ENaC by phosphorylating SGK1. (2010) (103)
Entry of B Cell Receptor into Signaling Domains Is Inhibited in Tolerant B Cells (2000) (103)
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies (2019) (103)
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. (2007) (101)
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile (2011) (101)
P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates (2016) (100)
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. (2008) (100)
Recent advances in chemical approaches to the study of biological systems. (2001) (99)
Phosphospecific proteolysis for mapping sites of protein phosphorylation (2003) (99)
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics (2006) (95)
Bio-orthogonal affinity purification of direct kinase substrates. (2005) (95)
A Complex-based Reconstruction of the Saccharomyces cerevisiae Interactome *S⃞ (2009) (94)
Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis (2003) (92)
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant (2021) (91)
Protein Kinase Cϵ Regulates γ-Aminobutyrate Type A Receptor Sensitivity to Ethanol and Benzodiazepines through Phosphorylation of γ2 Subunits* (2007) (89)
Small molecule recognition of c-Src via the Imatinib-binding conformation. (2008) (89)
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity (2010) (87)
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. (2007) (86)
Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors (2013) (86)
Novel chemical genetic approaches to the discovery of signal transduction inhibitors. (2002) (85)
Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. (2010) (83)
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. (2003) (80)
A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor (2010) (80)
Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. (2008) (79)
Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. (2004) (79)
Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling (2011) (78)
The unfolded protein response signals through high-order assembly of Ire 1 (2008) (77)
Engineering of the Myosin-Iβ Nucleotide-binding Pocket to Create Selective Sensitivity to N 6-modified ADP Analogs* (1999) (76)
Protein Kinase Cδ Regulates Ethanol Intoxication and Enhancement of GABA-Stimulated Tonic Current (2008) (76)
The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. (2010) (76)
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. (2004) (75)
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. (2011) (75)
Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib (2016) (74)
Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. (2014) (73)
TrkB and Protein Kinase M ζ Regulate Synaptic Localization of PSD-95 in Developing Cortex (2011) (72)
Chemical Genetic Approach for Kinase‐Substrate Mapping by Covalent Capture of Thiophosphopeptides and Analysis by Mass Spectrometry (2010) (72)
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. (2008) (72)
A mechanism-based cross-linker for the identification of kinase-substrate pairs. (2004) (71)
Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. (2010) (71)
New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs). (2010) (71)
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. (2015) (68)
Chemical genetic strategy for targeting protein kinases based on covalent complementarity (2011) (67)
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents (2010) (67)
Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. (2017) (67)
Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells. (2011) (66)
Site-specific incorporation of phosphotyrosine using an expanded genetic code (2017) (66)
The logic and design of analog-sensitive kinases and their small molecule inhibitors. (2014) (65)
Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. (2005) (65)
The Cyclin-Dependent Kinase (CDK) Family Member PNQALRE/CCRK Supports Cell Proliferation but has no Intrinsic CDK-Activating Kinase (CAK) Activity (2006) (65)
Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma (2008) (64)
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways (2012) (63)
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. (2002) (63)
Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. (2008) (62)
Structural and functional basis for RNA cleavage by Ire1 (2011) (62)
Tuning a three-component reaction for trapping kinase substrate complexes. (2008) (61)
Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2* (2010) (61)
Targeting the gatekeeper residue in phosphoinositide 3-kinases. (2005) (60)
A kinase sequence database: sequence alignments and family assignment (2002) (60)
Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation (2008) (59)
SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. (2009) (59)
Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling*S⃞ (2008) (58)
Chemical Inactivation of Cdc7 Kinase in Budding Yeast Results in a Reversible Arrest That Allows Efficient Cell Synchronization Prior to Meiotic Recombination (2006) (58)
A Chemical Genomics Study Identifies Snf1 as a Repressor of GCN4 Translation* (2008) (58)
Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling (2013) (57)
Design and Use of Analog‐Sensitive Protein Kinases (2004) (57)
GABAA Receptor Trafficking Is Regulated by Protein Kinase Cε and the N-Ethylmaleimide-Sensitive Factor (2010) (56)
Inhibitor scaffolds as new allele specific kinase substrates. (2002) (56)
Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. (2013) (56)
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. (2015) (55)
Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development (2014) (55)
MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development (2014) (55)
Tuning the Activation Threshold of a Kinase Network by Nested Feedback Loops (2009) (54)
Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells (2012) (54)
Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity (2014) (54)
Acquisition of inhibitor-sensitive protein kinases through protein design. (1999) (54)
Phosphorylation of the src Epithelial Substrate Trask Is Tightly Regulated in Normal Epithelia but Widespread in Many Human Epithelial Cancers (2009) (53)
A pharmacological map of the PI 3K family defines a role for p 110 alpha in insulin signaling (2017) (53)
Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. (2012) (53)
Correction: Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species (2009) (53)
Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer (2018) (52)
Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. (2013) (52)
GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf (2020) (52)
Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors (2017) (52)
A chemical genetic approach for the identification of direct substrates of protein kinases. (2003) (52)
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. (2008) (51)
Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe (2007) (51)
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. (2017) (51)
A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast (2012) (50)
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic (2015) (50)
Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry (2006) (50)
Corrigendum: The p110[delta] structure: mechanisms for selectivity and potency of new PI(3)K inhibitors (2010) (50)
Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase‐Directed Library (2000) (49)
A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39 (2006) (49)
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 (2011) (48)
Differential genetic interactions of yeast stress response MAPK pathways (2015) (48)
Development of a Chemical Genetic Approach for Human Aurora B Kinase Identifies Novel Substrates of the Chromosomal Passenger Complex* (2012) (48)
Protein Engineering of Protein Kinase A Catalytic Subunits Results in the Acquisition of Novel Inhibitor Sensitivity* (2002) (48)
Modified AutoDock for accurate docking of protein kinase inhibitors (2002) (48)
An Antibody‐Mediated Redox Reaction (1988) (48)
Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. (2017) (47)
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. (2016) (47)
Cdk 1-Dependent Phosphorylation of Cdc 13 Coordinates Telomere Elongation during Cell-Cycle Progression (2009) (46)
A membrane capture assay for lipid kinase activity (2007) (45)
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. (2015) (45)
PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival (2013) (45)
Tyrosine kinases: modular signaling enzymes with tunable specificities. (1995) (45)
Specific Inhibition of Elm1 Kinase Activity Reveals Functions Required for Early G1 Events (2003) (44)
Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe (2011) (43)
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing (2020) (43)
A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation (2008) (43)
Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic (2004) (43)
TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions. (2014) (43)
Catalytic antibodies: A new class of transition-state analogues used to elicit hydrolytic antibodies (1990) (43)
The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. (2008) (42)
Inhibition of Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full T cell receptor signaling (2013) (42)
Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction (1994) (41)
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells. (2020) (41)
Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage (2006) (39)
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. (2012) (39)
A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. (2019) (39)
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. (2007) (38)
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma (2012) (38)
Separate Domains of Fission Yeast Cdk9 (P-TEFb) Are Required for Capping Enzyme Recruitment and Primed (Ser7-Phosphorylated) Rpb1 Carboxyl-Terminal Domain Substrate Recognition (2012) (38)
Small molecule inhibition of Csk alters affinity recognition by T cells (2015) (37)
Redirecting the immune response: ligand-mediated immunogenicity (1991) (37)
Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen (2016) (37)
SR protein kinases promote splicing of nonconsensus introns (2015) (37)
TFIIH-Associated Cdk 7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser 7 Residues , Promoter-Proximal Pausing , and Termination by RNA Polymerase II ! † (2019) (37)
The AMP-activated Protein Kinase Snf1 Regulates Transcription Factor Binding, RNA Polymerase II Activity, and mRNA Stability of Glucose-repressed Genes in Saccharomyces cerevisiae* (2012) (36)
The In Vivo Response of Stem and Other Undifferentiated Spermatogonia to the Reversible Inhibition of Glial Cell Line‐Derived Neurotrophic Factor Signaling in the Adult (2012) (35)
Transforming Growth Factor β1 Inhibits Cystic Fibrosis Transmembrane Conductance Regulator-dependent cAMP-stimulated Alveolar Epithelial Fluid Transport via a Phosphatidylinositol 3-Kinase-dependent Mechanism* (2009) (35)
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 (2016) (35)
Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange (2018) (35)
Discovery and functional characterization of a neomorphic PTEN mutation (2015) (34)
the p 110 structure : mechanisms for selectivity and potency of new pI ( 3 ) K inhibitors (2010) (34)
Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. (2017) (33)
Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. (2008) (33)
The effect of H 3 K 79 dimethylation and H 4 K 20 trimethylation on nucleosome and chromatin structure (2008) (32)
High‐Dose Soluble Antigen: Peripheral T‐Cell Proliferation or Apoptosis (1994) (32)
Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. (2008) (32)
Genetic deletion of trkB.T1 increases neuromuscular function. (2012) (32)
Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. (2013) (32)
Chemical Genetic Engineering of G Protein-coupled Receptor Kinase 2* (2005) (31)
Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy (2014) (31)
Engineering the serine/threonine protein kinase Raf‐1 to utilise an orthogonal analogue of ATP substituted at the N 6 position (2004) (30)
Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding (2016) (30)
Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture (2015) (30)
Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. (2008) (30)
Use of a semisynthetic epitope to probe histidine kinase activity and regulation. (2010) (29)
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease (2017) (29)
Chemical Genetic Blockade of Transformation Reveals Dependence on Aberrant Oncogenic Signaling (2002) (29)
A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors (2018) (29)
PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma (2020) (29)
The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Active Site and Cleavage Sequence Differentially Regulate Protein Secretion from Proteolysis* (2014) (29)
KRAS is vulnerable to reversible switch-II pocket engagement in cells (2021) (29)
Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP (2018) (28)
Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. (2011) (28)
An Optimized Chromatographic Strategy for Multiplexing In Parallel Reaction Monitoring Mass Spectrometry: Insights from Quantitation of Activated Kinases* (2016) (28)
INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC (2017) (28)
Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. (2013) (27)
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant (2021) (26)
Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities. (2000) (25)
Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia (2006) (25)
Bifunctional Small Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins (2019) (25)
Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. (2007) (25)
Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs (2013) (24)
The brain‐derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value (2008) (23)
Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. (2004) (23)
Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. (2012) (23)
Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues. (2003) (23)
Cutting Edge: A Chemical Genetic System for the Analysis of Kinases Regulating T Cell Development 1 (2003) (23)
Radiotherapy Followed by Aurora Kinase Inhibition Targets Tumor-Propagating Cells in Human Glioblastoma (2014) (21)
Highly efficient green fluorescent protein-based kinase substrates. (1999) (20)
Selective kinase inhibition by exploiting differential pathway sensitivity. (2006) (20)
Phage-display evolution of tyrosine kinases with altered nucleotide specificity. (2001) (20)
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S) (2022) (20)
A remodelled protease that cleaves phosphotyrosine substrates. (2007) (20)
Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. (2014) (20)
Small‐Molecule Kinase‐Inhibitor Target Assessment (2005) (20)
Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer (2012) (19)
Responses to Glial Cell Line-Derived Neurotrophic Factor Change in Mice as Spermatogonial Stem Cells Form Progenitor Spermatogonia which Replicate and Give Rise to More Differentiated Progeny1 (2014) (19)
Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer (2015) (18)
Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. (2010) (18)
Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. (2017) (18)
Snf 1 Activation Loop Phosphorylation Is Controlled by Availability of the Phosphorylated Threonine 210 to the PP 1 Phosphatase * (2007) (18)
A Chemical Genetic Approach Reveals Distinct Mechanisms of EphB Signaling During Brain Development (2012) (17)
A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy. (2022) (16)
Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile (2022) (16)
Constitutive mTORC 1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication (2010) (16)
Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype (2017) (16)
A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice (2018) (15)
Bypassing Kinase Activity of the Tomato Pto Resistance Protein with Small Molecule Ligands* (2009) (15)
Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex (2019) (15)
Brain-restricted mTOR inhibition with binary pharmacology (2020) (15)
In Vivo Conditions to Identify Prkci Phosphorylation Targets Using the Analog-Sensitive Kinase Method in Zebrafish (2012) (14)
Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy (2018) (14)
A phage display selection of engrailed homeodomain mutants and the importance of residue Q50. (2004) (14)
Drugging the Next Undruggable KRAS Allele-Gly12Asp. (2022) (14)
The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells. (2020) (13)
Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers (2021) (13)
Enhanced selectivity for inhibition of analog-sensitive protein kinases through scaffold optimization (2007) (13)
Discovery of Dual Inhibitors of the Immune Cell PI 3 Ks p 110 d and p 110 g : a Prototype for New Anti-inflammatory Drugs (13)
Towards the Engineering of an Orthogonal Protein Kinase/Nucleotide Triphosphate Pair (2000) (13)
Targeting osteosarcoma (2014) (13)
Chemically targeting the PI 3 K family (2007) (12)
Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide. (2004) (12)
PLC-γ and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras (2013) (12)
Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment. (2017) (11)
A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins. (2012) (11)
Analog sensitive chemical inhibition of the DEAD‐box protein DDX3 (2016) (11)
Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases. (2016) (10)
A genetically selective inhibitor reveals a ZAP-70 catalytic-independent function in TREG cells (2010) (10)
Cooperative blockade of PKCα and JAK2 drives apoptosis in glioblastoma. (2019) (10)
A crosslinker based on a tethered electrophile for mapping kinase-substrate networks. (2014) (10)
Structural and functional basis for RNA cleavage by Ire 1 (2011) (9)
Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling (2016) (9)
Blocking HIV entry (1999) (9)
[17] Catalytic antibodies (1991) (9)
Generation of a Novel System for Studying Spleen Tyrosine Kinase Function in Macrophages and B Cells1 (2009) (8)
Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2 (2021) (8)
Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases. (2018) (7)
p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin (2019) (7)
Betacellulin drives therapy-resistance in glioblastoma. (2020) (7)
Erratum: EGFR signals to mTOR through PKC and independently of Akt in glioma (Science Signaling (2009) 2:60 (er4)) (2009) (7)
Chemical genetic inhibition of DEAD-box proteins using covalent complementarity (2018) (7)
Erratum: A surface on the androgen receptor that allosterically regulates coactivator binding (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 41, (16074-16079) DOI: 10.1073/pnas. 0708036104) (2007) (6)
State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides (2022) (6)
Dual Inhibition of PI 3 K A and mTOR as an Alternative Treatment for Kaposi ’ s Sarcoma (2008) (6)
Dissecting the biology of mTORC1 beyond rapamycin (2021) (6)
Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases. (2002) (5)
Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. (2018) (5)
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. (2017) (5)
Cell Chemical Biology: Home of Exciting Chemical Biology. (2016) (5)
Genetic or pharmaceutical blockade of p 110 d phosphoinositide 3-kinase enhances IgE production (5)
Spermatogonial Stem Cell Numbers Are Reduced by Transient Inhibition of GDNF Signaling but Restored by Self-Renewing Replication when Signaling Resumes (2021) (5)
Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice (2021) (4)
Dose-Dependent Effects of Focal Fractionated Irradiation on Secondary Malignant Neoplasms in Nf 1 Mutant Mice (2010) (4)
Covalent cross-linking of kinases with their corresponding peptide substrates. (2012) (4)
Structure and properties of a re-engineered homeodomain protein-DNA interface. (2006) (4)
Targeting KRAS G12C with Covalent Inhibitors (2021) (4)
Catalytic antibodies. (1990) (4)
The AMP-activated Protein Kinase Snf 1 Regulates Transcription Factor Binding , RNA Polymerase II Activity , and mRNA Stability of Glucose-repressed Genes in Saccharomyces cerevisiae * (2012) (4)
A Bounty of New Challenging Targets in Oncology for Chemical Discovery. (2019) (4)
A drug-drug interaction crystallizes a new entry point into the UPR. (2010) (4)
Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model. (1987) (4)
Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. (2011) (4)
Screening a hydroxystilbene library for selective inhibition of the B cell antigen receptor kinase cascade (1997) (4)
Abstract A46: Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers (2013) (4)
Cold shock domain–containing protein E1 is a posttranscriptional regulator of the LDL receptor (2022) (3)
Voices of Chemical Biology: Charting the Next Decade. (2016) (3)
The generation of antibody combining sites containing catalytic residues. (1991) (3)
INPP 4 B and PTEN Loss Leads to PI-3 , 4P 2 Accumulation and Inhibition of PI 3 K in TNBC (2017) (3)
A GTP-state specific cyclic peptide inhibitor of the GTPase Gαs (2020) (3)
MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA (2014) (3)
IFITM proteins assist cellular uptake of diverse linked chemotypes (2022) (3)
A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability (2022) (3)
Corrigendum: An integrated platform of genomic assays reveals small-molecule bioactivities (2008) (2)
Evolutionarily divergent mTOR remodels the translatome to drive rapid wound closure and regeneration (2021) (2)
Chemical Genetic Analysis of Protein Kinase Cascades (2002) (2)
Erratum: PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma (Science Translational Medicine DOI: 10.1016/j.bbcan.2016.06.002) (2020) (2)
PROTEIN KINASE C EPSILON REGULATES GABAA RECEPTOR SENSITIVITY TO ETHANOL AND BENZODIAZEPINES THROUGH PHOSPHORYLATION OF γ 2 SUBUNITS * (2007) (2)
PI-103, a Dual Inhibitor of Class I Phosphatidylinositide 3-Kinase and mTOR, Has Anti-Leukemic Activity in Acute Myeloid Leukemia. (2007) (2)
Dual Inhibition of PI3K A and mTOR as an Alternative Treatment for Kaposi’s Sarcoma (2008) (2)
Methods in Enzymology. Protein kinase inhibitors in research and medicine. Preface. (2014) (2)
Revealing Biological Specificity by Engineering Protein‐Ligand Interactions (2008) (2)
CELL BIOLOGY AND SIGNALING (2010) (2)
1 INHIBITION OF ZAP-70 KINASE ACTIVITY VIA AN ANALOG-SENSITIVE ALLELE BLOCKS T CELL RECEPTOR AND CD 28 SUPERAGONIST SIGNALING (2008) (2)
CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor (2020) (2)
Basal-subtype and MEK-PI3K feedback signaling determine susceptibility of breast cancer cells to MEK inhibition (2008) (2)
Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1 (2022) (2)
Chemically reprogramming the phospho‐transfer reaction to crosslink protein kinases to their substrates (2019) (2)
Chemicals Call Bacteria, and A New Membrane Protein Machine Answers (2005) (2)
A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek (2011) (2)
Abstract A45: Kinome rewiring reveals AURKA is a molecular barrier to the efficacy of PI3K/mTOR-pathway inhibitors in breast cancer (2018) (2)
Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development (2015) (2)
A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93 (2006) (1)
Brain-Specific Inhibition of mTORC1 by a Dual Drug Strategy: A Novel Approach for the Treatment of Alcohol Use Disorder (2020) (1)
Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer (2017) (1)
Drugging the undruggable: Ross Cagan interviews Kevan Shokat (2022) (1)
CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization (2022) (1)
p38γ MAPK contributes to left ventricular remodeling following pathological stress and disinhibits calpain through phosphorylation of calpastatin (2018) (1)
Catalytic antibodies. (1991) (1)
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors (2023) (1)
An Antibody-Mediated Redox Reaction. (1988) (1)
Abstract 1201: PTEN null expression is concordant in colorectal cancer primaries and metastases and associates with poor survival. (2013) (1)
Disease-Causing Mutations in the G Protein G a s Subvert the Roles of GDP and GTP Graphical Abstract Highlights (2019) (1)
Tissue-restricted inhibition of mTOR using chemical genetics (2022) (1)
Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators. (2006) (1)
Chemical genetics to map kinase signaling pathways (473.3) (2014) (1)
A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9. (2018) (1)
Resource Chemical Genetics of Rapamycin-Insensitive TORC 2 in S . cerevisiae (2013) (1)
Title Cofactor-mediated conformational control in the bifunctional kinase / RNase Ire 1 Permalink (2011) (1)
Targeting the Translational Apparatus in Mycn-Driven Medulloblastoma (2014) (1)
A chemical-genetic approach to inhibit Csk activates T cells independently of the T cell receptor (35.4) (2009) (1)
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK (2015) (1)
Protein kinase inhibitors in research and medicine (2014) (1)
A novel analog-sensitive allele of Csk reveals its kinase-independent role in the regulation of T cell receptor signaling (109.35) (2011) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30. (2010) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07. (2010) (0)
Abstract PR01: Inhibitory role of phosphatidylinositol-3,4-bisphosphate in triple-negative breast cancers (2015) (0)
Urological Survey Uro-Science Re : Cellular Uptake and Anticancer Activity of Carboxylated Gallium (2016) (0)
label its direct substrates Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely (1997) (0)
Crystal Structure of Small Molecule Disulfide 2C07 Bound to K-Ras Cys Light M72C GDP (2017) (0)
Knock-outs and inhibitors: one and the same? (2006) (0)
Abstract IA08: Direct covalent inhibitors of mutant K-Ras (2023) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5. (2010) (0)
Chemical Immunological Identification of Direct Kinase Substrates (2006) (0)
Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS (2014) (0)
Abstract 16980: A High Throughput Assay for PCSK9 Proteolysis Reveals its Substrate Specificity (2017) (0)
Abstract PR4: Incomplete inhibition of phosphorylation of 4EBP1 is a mechanism for KRAS driven resistance to the ATP-competitive mTOR inhibitor PP242 in colorectal cancer (2012) (0)
complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284 (2008) (0)
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103 (2010) (0)
Structure of 3MB-PP1 bound to analog-sensitive Src kinase (2013) (0)
Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GDP (2017) (0)
Catalytic Antibodies: A New Class of Transition‐State Analogues Used to Elicit Hydrolytic Antibodies (1991) (0)
Abstract 1653: Highly effective treatment of HER2-amplified breast cancers through the complete inactivation of the HER2-HER3 tumorigenic driver (2010) (0)
CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA (2017) (0)
P0119. Pharmacological inhibitors of S-nitroso-glutathione reductase (2006) (0)
Importance of PI3 Kinase Family for Crosstalk between Chronic Lymphocytic Leukemia B Cells and the Stromal Microenvironment: Therapeutic Implications. (2007) (0)
ET-63TARGETING THE EGFR-STAT-NF-κB AXIS IN GLIOBLASTOMA (2014) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15. (2010) (0)
IDENTIFICATION OF NOVEL SUBSTRATES AND A PROTEIN INHIBITOR OF PHOSPHOINOSITIDE-DEPENDENT KINASE-1 (2000) (0)
Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group (2013) (0)
Crystal structure of c-Src in complex with pyrazolopyrimidine 5 (2008) (0)
Screening a Hydroxystilbene Library for Selective Inhibition of the B Cell Antigen Receptor Kinase Cascade. (1997) (0)
Star 12 bound to analog-sensitive Src kinase (2013) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941. (2010) (0)
PNAS Plus Significance Statements (2016) (0)
Specific Inhibition of Elm1 Kinase Activity Reveals Functions Required for Early G1 Events (2006) (0)
Abstract B48: Identification of novel drug interactions with MYC via a quantitative chemical-genetic interaction map (2015) (0)
Crystal Structure of small molecule acrylamide 11 covalently bound to K-Ras G12C (2013) (0)
CHAPTER 98 – Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors (2003) (0)
A Proteomic Co-Clinical Trial of BGJ-398 in FGFR-Driven Biliary Cancers (2018) (0)
Crystal Structure of H-Ras G12C, GDP-bound (2013) (0)
Aurora A Kinase Apo (2014) (0)
Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393 (2007) (0)
Comparative gene expression in developing cognitive circuits in common marmoset brain (2012) (0)
HMGB1 accelerates alveolar epithelial repair via an IL-1{beta}-dependent activation of TGF-{beta}1 by the {alpha}v{beta}6 integrin. (2010) (0)
Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy (2011) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13. (2010) (0)
Cholangiocarcinoma Hypersensitivity and SRC Dependence in Intrahepatic Isocitrate Dehydrogenase Mutations Confer Dasatinib (2016) (0)
Phage-Selected Homeodomain Bound to Unmodified DNA (2006) (0)
Activation of Unfolded Protein Response Signaling Pathways During Retinal Degeneration in P23H Rhodopsin Transgenic Rats (2008) (0)
A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAFV600E colorectal tumors (2022) (0)
Crystal Structure of T338C c-Src covalently bound to vinylsulfonamide-pyrazolopyrimidine 9 (2011) (0)
Abstract PR07: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism (2015) (0)
Structure of oligomeric kinase/RNase Ire1 in complex with an oligonucleotide (2011) (0)
Activation of Cl-permeable GABAA receptors elicits synaptic inhibition in mature neurons (2018) (0)
Crystal structure of human CBR1 in complex with Hydroxy-PP (2005) (0)
Abstract 2450: Identifying novel substrates of PLK2 using a chemical genetics approach (2015) (0)
Structure of ULK1 bound to a potent inhibitor (2015) (0)
and Spleen Tyrosine Kinase Function in Generation of a Novel System for Studying (2008) (0)
DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA (2019) (0)
Supporting Information Multi-step compositional remodeling of supported lipid membranes by interfacially active phosphatidylinositol kinases (2016) (0)
Progress Toward the Development of Inhibitors of 11beta-Hydroxysteroid dehydrogenase 2: Inhibition of Cortisol Catabolism in the Lung (2006) (0)
Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy (2022) (0)
Conditional protein knockout approach to synaptic erasure of old memories in mice (2001) (0)
Superior Colliculus Transmission in the Superficial Layers of the Mouse Postsynaptic Action of BDNF on GABAergic Synaptic (2012) (0)
THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA (2019) (0)
Chemistry & Biology editors announce changes to the editorial team. (2011) (0)
Author response: Small molecule inhibition of Csk alters affinity recognition by T cells (2015) (0)
Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic (2015) (0)
New chemical approaches to tracing cellular signal transduction cascades (1998) (0)
Abstract LB-311: Development of mutant-specific small molecule inhibitors of K-Ras. (2013) (0)
Abstract C88: Genomics, advocacy, and emerging therapeutics to address triple-negative breast cancer (TNBC) outcome disparities. (2016) (0)
Herbert Alternative Mode of Blood Vessel Formation Arterial-Venous Segregation by Selective Cell Sprouting : An (2012) (0)
Chemical Genetic Identification of Protein Kinase C Epsilon Substrates in Mouse Brain. (2023) (0)
PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells. (2009) (0)
Abstract PR15: Primary resistance to MAPK inhibition in BRAF-mutant cancer is determined by kinetics of feedback release (2013) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654. (2010) (0)
Role of neural EGF-like like protein 2 (NELL2) in neuronal differentiation of P19 cells (2012) (0)
Kinome rewiring reveals AURKA is a molecular barrier to the efficacy of PI3K/mTOR-pathway inhibitors in breast cancer (2017) (0)
Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C (2018) (0)
Crystal Structure of K-Ras WT, GDP-bound (2013) (0)
Crystal structure of CDK4 in complex with CyclinD1 and P27 (2019) (0)
Crystal Structure of compound 10 covalently bound to K-Ras G12C (2018) (0)
mTOR Through PKC and Independently of Akt in Glioma by Q.-W (2009) (0)
Abstract 3043: Akt-mTorc2 signaling underlies cellular addiction to HER3 signaling in HER2-amplified cancers. (2013) (0)
Abstract 2688: Drugging MYCN through an allosteric transition in Aurora A kinase (2014) (0)
Corrigendum to “Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry” [FEBS Lett. 580 (2006) 179–183] (2008) (0)
Aurora A in complex with CD532 (2014) (0)
Crystal structure of the kinase domain of Cryptosporidium parvum calcium dependent protein kinase in complex with 3-MB-PP1 (2009) (0)
Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase (2013) (0)
Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 (2014) (0)
Crystal structure of Src kinase domain in complex with covalent inhibitor (2007) (0)
An integrated platform of genome-wide assays reveals novel bioactivities of chemical probes (2008) (0)
Abstract 486: Uncovering novel PERK signaling pathways through chemical-genetic screening (2014) (0)
Structure guided Development of Functional Probes for Protein Kinases using Chemical Genetics (2007) (0)
ReviewFeatures of Selective Kinase Inhibitors (2005) (0)
Crystal structure of human Carbonyl Reductase 1 in complex with S-hydroxymethylglutathione (2008) (0)
Crystal structure of GDP-bound human GNAS R201C mutant (2018) (0)
Issue information (2018) (0)
functiondeletion of trkB.T1 increases neuromuscular (2012) (0)
Structure of ULK1 bound to an inhibitor (2015) (0)
Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma (2017) (0)
Green fluorescent protein-based protein kinase biosensor substrates. (2002) (0)
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2 (2022) (0)
HMGB1 accelerates alveolar epithelial repair via an IL‐1β‐dependent activation of TGF‐β1 by the αvβ6 integrin. (2010) (0)
Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1 (2008) (0)
Crystal structure of human Carbonyl Reductase 1 in complex with NADP (2008) (0)
Abstract 1973: Targeting activated alleles of EGFR derived from glioma and lung cancer: Correlating kinase active-site occupancy with efficacy (2010) (0)
Identifying ZAP-70 kinase-dependent and -independent functions in T cells using a chemical genetic approach (35.5) (2009) (0)
PI 3 K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras (2013) (0)
Abstract 3904: Overcoming resistance to HER2 inhibitors through cell based screening (2016) (0)
Pyrazolopyrimidine derivatives for use as antagonists kinase (2007) (0)
Abstract 12654: The Dual Roles of the PCSK9 Active Site: Evidence for an Intermolecular Proteolytic Mechanism and a Separate Secretion Signal Encoded After Proteolytic Maturation (2013) (0)
Formation Sprouting : An Alternative Mode of Blood Vessel Arterial-Venous Segregation by Selective Cell (2010) (0)
Effect of PIK3CA and KRAS mutations on sensitivity to ATP-competitive mTOR inhibitors in a primary xenograft model of colorectal carcinoma. (2012) (0)
Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism (2015) (0)
A genetically selective inhibitor reveals ZAP-70 kinase-dependent checkpoints in T cell development (64.15) (2011) (0)
Crystal structure of human CBR1 in complex with BiGF2. (2007) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474. (2010) (0)
Chemical genetic methods for studying protein kinases (2006) (0)
Crystal structure of K-Ras(G12D) GppNHp bound to cyclic peptide ligand KD2 (2020) (0)
Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C (2013) (0)
Something Old, Something New (2009) (0)
Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C (2013) (0)
Abstract B44: A systems approach combining genomics, advocacy, and emerging novel therapeutics to address triple-negative breast cancer (TNBC) outcomes disparities (2015) (0)
Title: A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-Resistant Tumors Model of Neuroendocrine Tumors (2018) (0)
Crystal Structure of the Kinase Domain of ABL in Complex with a Potent Rationally-Designed Derivative of the PP1 Inhibitor, AB129 (2012) (0)
Beyond the Gatekeeper: Imatinib- and Dasatinib-Resistant BCR-ABL/F317 Mutations Confer Cross-Resistance to VX-680 but Are Sensitive to a Structural Derivative of VX-680 (2008) (0)
A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90 (2006) (0)
News from Chemistry & Biology (2008) (0)
Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A (2014) (0)
Abstract PO017: HBV alters YAP regulation in liver cancer by remodeling PP2A complexes (2022) (0)
Genome-Wide Screening Reveals CSDE1 as a Novel Regulator of the LDL Receptor (2020) (0)
Small molecule inhibition of ZAP‐70 kinase activity (2006) (0)
Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors (2010) (0)
Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex (2019) (0)
Abstract C68: Using a chemical genetic approach to define the role of CDK2 in normal and transformed cell lines (2009) (0)
ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA (2015) (0)
From Powerful Review Articles to Research Breakthroughs. (2016) (0)
Complex of PI3K gamma with an inhibitor (2008) (0)
Corrigendum to “Screening a hydroxystilbene library for selective inhibition of the B cell antigen receptor kinase cascade” [Tetrahedron 53 (1997) 11995] (1998) (0)
Abstract IA25: Third-generation inhibitors of mTOR (2017) (0)
Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C (2013) (0)
in mouse muscle Adaptation to lengthening contraction-induced injury (2015) (0)
Prolonged G2 arrest and Chk1 overactivation following DNA damage in the absence of DNA-PK activity (2005) (0)
Cellpanelr: identify predictive biomarkers from cell line panel response data (2022) (0)
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 (2010) (0)
Protein Kinase C Regulates -Aminobutyrate Type A Receptor Sensitivity to Ethanol and Benzodiazepines (2007) (0)
AURKA is a molecular barrier to the efficacy of PI 3 K / mTOR-pathway inhibitors in breast cancer (2017) (0)
Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP102, a multitargeted kinase inhibitor (2008) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114. (2010) (0)
73 Differential pathway resiliency in response to MAPK inhibition in BRAF-mutant cancer (2014) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14. (2010) (0)
Structure of ULK1 bound to a selective inhibitor (2015) (0)
Developmentthe Analysis of Kinases Regulating T Cell Cutting Edge: A Chemical Genetic System for (2003) (0)
c-Src kinase domain in complex with small molecule inhibitor (2008) (0)
ighly Efficient Green Fluorescent Protein-Based inase Substrates (1998) (0)
ELUCIDATING THE ROLE OF P38γ IN PATHOLOGICAL CARDIAC HYPERTROPHY (2014) (0)
Crystal structure of human Carbonyl Reductase 1 in complex with glutathione (2008) (0)
Crystal Structure of H-Ras G12C, GMPPNP-bound (2013) (0)
Crystal structure of kinase domain of TgCDPK1 in presence of 3BrB-PP1 (2010) (0)
Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP (2002) (0)
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2 (2022) (0)
Dominant p110α activation in endometrial cancer. (2007) (0)
Crystal structure of c-Src in complex with pyrazolopyrimidine 3 (2008) (0)
Abstract 3837: PI-3 kinase acts upstream of oncogenic Ras in hematopoietic cells through a cytokine-PLCγ-RasGRP pathway (2010) (0)
junctionseffects on diaphragm neuromuscular (2015) (0)
News from the Chemistry & Biology editorial team. (2012) (0)
Abstract LB-190: RAF inhibitors transactivate RAF dimers and ERK signaling in a wild-type BRAF-dependent manner (2010) (0)
Crystal structure of GppNHp-bound GNAS in complex with the cyclic peptide inhibitor GsIN-1 (2021) (0)
Reflecting on the past and looking forward to the future of bridging chemistry and biology. (2014) (0)
Abstract PL04-03: Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions. (2013) (0)
Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C (2017) (0)
meiotic recombination in yeast Cdc 28 Clb 5 ( CDKS ) and Cdc 7 Dbf 4 ( DDK ) collaborate to initiate data (2008) (0)
Synergistic effects of multi-level targeting of the MAPK and PI3-kinase pathways in breast cancer cells. (2007) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta. (2010) (0)
Synthesis and evaluation of indazole based analog sensitive Akt inhibitors w z (2010) (0)
A chemical–genetic study of EphB signaling identifies kinase-dependent developmental processes (2012) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39. (2010) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666. (2010) (0)
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE (2010) (0)
Abstract SY19-01: Chemical genetic investigations of protein and lipid kinase signaling. (2011) (0)
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06. (2010) (0)
Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp (2017) (0)
Supporting Online Material for Rewiring of Genetic Networks in Response to DNA Damage (2010) (0)
Diaphragm Neuromuscular Junctions Synaptic Vesicle Distribution and Release at Rat (2015) (0)
HBV rewires liver cancer signaling by altering PP2A complexes (2023) (0)
Our Advisors, Our Ambassadors, Our Editorial Board Members. (2016) (0)
Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound (2013) (0)
Treatment for Kaposi's Sarcoma and mTOR as an Alternative α Dual Inhibition of PI3K (2008) (0)
Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1 (2011) (0)
Abstract LB-216: Integrated analysis of differential pathway resiliency in response to MAPK inhibition in BRAF-mutant cancer (2014) (0)
endosome-linked pathways. (2009) (0)

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