Kevin Brindle
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British radiologist
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Why Is Kevin Brindle Influential?
(Suggest an Edit or Addition)According to Wikipedia, Kevin Michael Brindle, , is a British biochemist, currently Professor of Biomedical Magnetic Resonance in the Department of Biochemistry at the University of Cambridge and a Senior Group Leader at Cancer Research UK. He is known for developing magnetic resonance imaging techniques for use in cell biochemistry and new imaging methods for early detection, monitoring, and treatment of cancer.
Kevin Brindle's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations (2001) (1017)
- Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy (2007) (811)
- The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014) (757)
- Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate (2008) (722)
- Imaging biomarker roadmap for cancer studies (2016) (718)
- Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. (2011) (642)
- The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis (2011) (552)
- Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent (2001) (531)
- Enhanced detection of circulating tumor DNA by fragment size analysis (2018) (525)
- The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations (2005) (520)
- Clinical proton MR spectroscopy in central nervous system disorders. (2013) (491)
- New approaches for imaging tumour responses to treatment (2008) (429)
- Challenges to curing primary brain tumours (2019) (414)
- Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography (2015) (356)
- Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene (2001) (308)
- Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia (2013) (272)
- Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors (2009) (271)
- Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy (2011) (256)
- Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology (2018) (255)
- Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus (2012) (234)
- Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose (2013) (227)
- Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi Anemia (2011) (205)
- Methodological consensus on clinical proton MRS of the brain: Review and recommendations (2019) (202)
- Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation (2012) (183)
- Proton NMR analysis of plasma is a weak predictor of coronary artery disease (2006) (175)
- The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. (2005) (172)
- Application of spin-echo nuclear magnetic resonance to whole-cell systems. Membrane transport. (1979) (159)
- Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1‐13C]pyruvate and 13C magnetic resonance spectroscopic imaging (2011) (157)
- Hyperpolarized [1-13C]-Ascorbic and Dehydroascorbic Acid: Vitamin C as a Probe for Imaging Redox Status in Vivo (2011) (154)
- p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. (2004) (149)
- Phospholipid bilayer contribution to 31P NMR spectra in vivo (1989) (148)
- Imaging metabolism with hyperpolarized (13)C-labeled cell substrates. (2015) (148)
- 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C‐labeled glutamine (2008) (147)
- Kinetic Modeling of Hyperpolarized 13C Label Exchange between Pyruvate and Lactate in Tumor Cells* (2011) (145)
- Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. (2002) (140)
- Imaging Cell Death (2014) (136)
- Inhibition of Phosphatidylcholine Biosynthesis following Induction of Apoptosis in HL-60 Cells* (1999) (133)
- Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials. (2003) (132)
- Biomedical applications of hyperpolarized 13C magnetic resonance imaging (2009) (130)
- Superparamagnetic Iron Oxide-Labeled Schwann Cells and Olfactory Ensheathing Cells Can Be Traced In Vivo by Magnetic Resonance Imaging and Retain Functional Properties after Transplantation into the CNS (2004) (127)
- Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate (2010) (125)
- A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion. (2002) (125)
- Uric Acid Promotes Tumor Immune Rejection (2004) (120)
- Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae. (1992) (118)
- 31P NMR magnetization-transfer measurements of ATP turnover during steady-state isometric muscle contraction in the rat hind limb in vivo. (1989) (116)
- Magnetization transfer measurements of exchange between hyperpolarized [1‐13C]pyruvate and [1‐13C]lactate in a murine lymphoma (2010) (113)
- A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast. (2001) (112)
- A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment. (2009) (107)
- Imaging breast cancer using hyperpolarized carbon-13 MRI (2020) (102)
- The appearance of neutral lipid signals in the 1H NMR spectra of a myeloma cell line correlates with the induced formation of cytoplasmic lipid droplets (1993) (102)
- Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status. (1998) (102)
- Physiological Levels of Mammalian Uncoupling Protein 2 Do Not Uncouple Yeast Mitochondria* (2001) (100)
- NMR methods for measuring enzyme kinetics in vivo (1988) (100)
- Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients (2018) (100)
- Imaging pH with hyperpolarized 13C (2011) (95)
- Assessing responses to cancer therapy using molecular imaging. (2006) (94)
- Direct enhancement of nuclear singlet order by dynamic nuclear polarization. (2012) (94)
- Mitochondrial dysfunction in patients with primary congenital insulin resistance. (2011) (92)
- The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability. (2001) (89)
- A comparison of quantitative methods for clinical imaging with hyperpolarized 13C‐pyruvate (2016) (84)
- Magnetic resonance imaging with hyperpolarized [1,4-13C2]fumarate allows detection of early renal acute tubular necrosis (2012) (83)
- Exploring isonitrile-based click chemistry for ligation with biomolecules. (2011) (81)
- ctDNA monitoring using patient-specific sequencing and integration of variant reads (2020) (80)
- Detection of apoptosis using the C2A domain of synaptotagmin I. (2004) (79)
- Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates. (1999) (78)
- Discrimination of pathogenic clinical isolates and laboratory strains of Bacillus cereus by NMR-based metabolomic profiling. (2005) (77)
- Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain. (1999) (77)
- Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profiling. (2007) (76)
- Induction of apoptosis in two mammalian cell lines results in increased levels of fructose‐1,6‐Bisphosphate and CDP‐choline as determined by 31P MRS (1998) (75)
- 19F NMR measurements of the rotational mobility of proteins in vivo. (1997) (74)
- Mitochondrial Proton Leak and the Uncoupling Proteins (1999) (74)
- ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung (2020) (74)
- Imaging sialylated tumor cell glycans in vivo (2011) (73)
- Detection of Tumor Response to a Vascular Disrupting Agent by Hyperpolarized 13C Magnetic Resonance Spectroscopy (2010) (73)
- Dual-modality gene reporter for in vivo imaging (2013) (73)
- Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI (2020) (71)
- Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization. (2012) (71)
- Early detection of cancer (2022) (70)
- MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model (2015) (69)
- Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent. (2008) (67)
- Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells. (2011) (66)
- Techniques: Visualizing apoptosis using nuclear magnetic resonance. (2003) (66)
- Metabolic Glycan Imaging by Isonitrile–Tetrazine Click Chemistry (2013) (66)
- Differential sensitivity of two adenocarcinoma xenografts to the anti‐vascular drugs combretastatin A4 phosphate and 5,6‐dimethylxanthenone‐4‐acetic acid, assessed using MRI and MRS (2002) (66)
- What Do Magnetic Resonance–Based Measurements of Pi→ATP Flux Tell Us About Skeletal Muscle Metabolism? (2012) (64)
- Imaging Cell Surface Glycosylation in Vivo Using “Double Click” Chemistry (2013) (64)
- Detection of tumor glutamate metabolism in vivo using 13C magnetic resonance spectroscopy and hyperpolarized [1‐13C]glutamate (2011) (63)
- 1H MRS‐visible lipids accumulate during apoptosis of lymphoma cells in vitro and in vivo (2005) (62)
- Determination of buffering capacity of rat myocardium during ischemia. (1988) (61)
- A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells. (1993) (61)
- 31P NMR magnetization-transfer measurements of flux between inorganic phosphate and adenosine 5'-triphosphate in yeast cells genetically modified to overproduce phosphoglycerate kinase. (1988) (58)
- 31P-NMR saturation transfer measurements of exchange between Pi and ATP in the reactions catalysed by glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase in vitro. (1987) (58)
- Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models. (2018) (57)
- Changes in phosphatidylethanolamine metabolism in regenerating rat liver as measured by 31P-NMR. (1992) (56)
- Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer (2014) (55)
- MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter (2016) (55)
- Comparison of the C2A domain of synaptotagmin-I and annexin-V as probes for detecting cell death. (2010) (55)
- Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation (2017) (54)
- Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate (2016) (52)
- Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts. (1995) (51)
- Hyperpolarized 13C MRI and PET: In Vivo Tumor Biochemistry (2011) (51)
- Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI. (2019) (51)
- 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells (2017) (50)
- Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1‐13C]lactate and [1‐13C]pyruvate (2013) (50)
- 31P NMR measurements of myocardial pH in vivo. (1988) (49)
- NMR studies of kinetics in cells and tissues (1987) (49)
- Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse (2013) (48)
- Probing Lactate Dehydrogenase Activity in Tumors by Measuring Hydrogen/Deuterium Exchange in Hyperpolarized l-[1-13C,U-2H]Lactate (2012) (47)
- Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy. (2010) (46)
- Amplification of TRIM44: Pairing a Prognostic Target With Potential Therapeutic Strategy (2014) (45)
- Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4. (2002) (45)
- Identifying active vascular microcalcification by 18 F-sodium fluoride positron emission (2015) (44)
- In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding. (2014) (43)
- 31P NMR magnetization transfer study of the control of ATP turnover in Saccharomyces cerevisiae. (1996) (42)
- 31P-NMR saturation transfer measurements of phosphate consumption in Saccharomyces cerevisiae (1985) (41)
- Dual-sugar imaging using isonitrile and azido-based click chemistries. (2013) (41)
- A 1H n.m.r. study of isotope exchange catalysed by glycolytic enzymes in the human erythrocyte. (1982) (40)
- Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue (2001) (40)
- H NMR-based metabolite profiling as a potential selection tool for breeding passive resistance against Fusarium head blight (FHB) in wheat. (2007) (40)
- Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment (2014) (39)
- Hyperpolarized [U‐2H, U‐13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells (2015) (39)
- Apoptosis detection using magnetic resonance imaging and spectroscopy (2005) (39)
- Emerging Technologies to Image Tissue Metabolism. (2019) (38)
- Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors. (2015) (38)
- Mapping of oxygen tension and cell distribution in a hollow-fiber bioreactor using magnetic resonance imaging. (1997) (37)
- Imaging tumor metabolism using positron emission tomography. (2015) (37)
- A p.m.r. isotope-exchange method for studying the kinetic properties of dehydrogenases in intact cells. (1982) (37)
- Monitoring T‐lymphocyte trafficking in tumors undergoing immune rejection (2005) (36)
- Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients (2021) (36)
- 1H NMR measurements of enzyme-catalyzed 15N-label exchange (1984) (36)
- Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres (2006) (35)
- Dynamic 1H imaging of hyperpolarized [1‐13C]lactate in vivo using a reverse INEPT experiment (2017) (34)
- Functional assessment of tissue-engineered meniscal cartilage by magnetic resonance imaging and spectroscopy. (2003) (34)
- Single shot three‐dimensional pulse sequence for hyperpolarized 13C MRI (2016) (33)
- Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites. (2018) (32)
- Observation of carbon labelling in cell metabolites using proton spin echo NMR. (1982) (31)
- Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma (2017) (31)
- Estimation of the intracellular free ADP concentration by 19F NMR studies of fluorine-labeled yeast phosphoglycerate kinase in vivo. (1993) (30)
- Imaging mouse cancer models in vivo using reporter transgenes. (2013) (30)
- Watching tumours gasp and die with MRI: the promise of hyperpolarised 13C MR spectroscopic imaging. (2012) (29)
- Mitochondrial Citrate Synthase Is Immobilized in Vivo * (1999) (29)
- A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging. (2007) (29)
- Molecular imaging using magnetic resonance: new tools for the development of tumour therapy. (2003) (29)
- Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy* (2016) (29)
- Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. (1992) (28)
- Measurements of exchange in the reaction catalysed by creatine kinase using 14C and 15N isotope labels and the NMR technique of saturation transfer. (1985) (28)
- Selecting short DNA fragments in plasma improves detection of circulating tumour DNA (2017) (28)
- Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma. (2018) (28)
- 19F NMR detection of a fluorine‐labelled enzyme in vivo (1989) (28)
- A 1H n.m.r. study of the kinetic properties expressed by glyceraldehyde phosphate dehydrogenase in the intact human erythrocyte. (1982) (28)
- Studies of lactate dehydrogenase in the purified state and in intact erythrocytes. (1982) (28)
- Magnetic resonance imaging is more sensitive than PET for detecting treatment-induced cell death-dependent changes in glycolysis. (2019) (28)
- Influence of stirring-induced mixing on cell proliferation and extracellular matrix deposition in meniscal cartilage constructs based on polyethylene terephthalate scaffolds. (2005) (28)
- A comparison of 31P-NMR saturation transfer and isotope-exchange measurements of creatine kinase kinetics in vitro. (1984) (27)
- Detection of transgene expression using hyperpolarized 13C urea and diffusion‐weighted magnetic resonance spectroscopy (2015) (27)
- Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy. (2002) (27)
- A 1H-NMR study of the activity expressed by lactate dehydrogenase in the human erythrocyte. (1986) (26)
- Characterization of image heterogeneity using 2D Minkowski functionals increases the sensitivity of detection of a targeted MRI contrast agent (2009) (25)
- Measurements of the Growth and Distribution of Mammalian Cells in a Hollow–Fiber Bioreactor Using Nuclear Magnetic Resonance Imaging (1994) (25)
- SPECT imaging of myocardial infarction using 99mTc-labeled C2A domain of synaptotagmin I in a porcine ischemia-reperfusion model. (2007) (25)
- Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer (2020) (25)
- Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent (2017) (24)
- Site‐Selective Modification of Proteins with Oxetanes (2017) (24)
- Measurement of bioreactor perfusion using dynamic contrast agent-enhanced magnetic resonance imaging. (2001) (24)
- Tumor Cell-Derived Nitric Oxide Is Involved in the Immune-Rejection of an Immunogenic Murine Lymphoma (2004) (24)
- Editing of 31P NMR spectra of heart in vivo (1987) (24)
- Metabolic consequences of p300 gene deletion in human colon cancer cells. (2006) (23)
- Spectral Editing in 31P NMR Spectra of Human Brain (1985) (23)
- Late Imaging with [1-11C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET (2014) (23)
- (E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent. (2011) (23)
- 31P NMR measurements of the ADP concentration in yeast cells genetically modified to express creatine kinase. (1990) (23)
- CARS based label‐free assay for assessment of drugs by monitoring lipid droplets in tumour cells (2014) (23)
- Brain Tumor Imaging. (2017) (22)
- Hyperpolarized 13C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer (2020) (22)
- Imaging and ‘omic’ methods for the molecular diagnosis of cancer (2010) (22)
- Versatile and enhanced tumour modelling in mice via somatic cell transduction (2014) (22)
- Assessment of anti-angiogenic and anti-vascular therapeutics using Magnetic Resonance Imaging: recommendations for appropriate methodology for clinical trials. (2003) (22)
- A multinuclear NMR study of 2,3-bisphosphoglycerate metabolism in the human erythrocyte. (1984) (22)
- Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line. (2000) (22)
- Oatp1 Enhances Bioluminescence by Acting as a Plasma Membrane Transporter for d-luciferin (2014) (22)
- Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy (2016) (21)
- Immune cell‐induced synthesis of NO and reactive oxygen species in lymphoma cells causes their death by apoptosis (2005) (21)
- Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging (2021) (21)
- 31P-NMR saturation transfer studies of aerobic Escherichia coli cells. (1988) (20)
- Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue (2018) (20)
- Effects of fasting on serial measurements of hyperpolarized [1‐13C]pyruvate metabolism in tumors (2016) (20)
- Analysis of 13C and 14C labeling in pyruvate and lactate in tumor and blood of lymphoma‐bearing mice injected with 13C‐ and 14C‐labeled pyruvate (2018) (20)
- Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells (2020) (20)
- Development of Timd2 as a reporter gene for MRI (2015) (20)
- Diffusion weighted imaging and magnetic resonance spectroscopy in a low flow ischaemia model due to endothelin induced vasospasm (2000) (19)
- Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I (2017) (19)
- Evaluation of engineered meniscal cartilage constructs based on different scaffold geometries using magnetic resonance imaging and spectroscopy. (2006) (19)
- Spin ECHO proton NMR studies of the metabolism of malate and fumarate in human erythrocytes. Dependence on free NAD levels. (1982) (18)
- 31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells. (1990) (18)
- Increased hyperpolarized [1‐13C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13C‐labelled bicarbonate (2018) (18)
- Detection of colorectal dysplasia using fluorescently labelled lectins (2015) (18)
- Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response (2016) (17)
- A comparison of one-dimensional and two-dimensional NMR methods for measuring enzyme-catalyzed exchange (1984) (17)
- Studies of pyruvate-water isotope exchange catalysed by erythrocytes and proteins. (1981) (17)
- Diazo group as a new chemical reporter for bioorthogonal labelling of biomolecules (2014) (16)
- 13C magnetic resonance spectroscopic imaging of hyperpolarized [1‐13C, U‐2H5] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo (2015) (16)
- [18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma (2018) (16)
- Analysis of CHO-K1 cell growth in a fixed bed bioreactor using magnetic resonance spectroscopy and imaging (1999) (16)
- Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR. (2016) (16)
- Ultra-early response assessment in lymphoma treatment: [18F]FDG PET/MR captures changes in glucose metabolism and cell density within the first 72 hours of treatment (2018) (15)
- Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates (2018) (15)
- Erratum: Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy (2007) (15)
- Early detection of tumour immune-rejection using magnetic resonance imaging (2003) (14)
- Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging (2015) (14)
- The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models (2016) (14)
- 31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle (2016) (13)
- A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1‐13C]pyruvate and [1‐13C]lactate (2017) (13)
- The inhibition of erythrocyte glyceraldehyde-3-phosphate dehydrogenase. In situ PMR studies. (1984) (12)
- Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T (2020) (12)
- Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized 13C-labeled cell metabolite and water protons (2014) (12)
- Metabolomics: Pandora's Box or Aladdin's Cave? (2003) (12)
- Tissue Engineering of Meniscal Cartilage Using Perfusion Culture (2002) (12)
- Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging (2015) (11)
- Investigating the performance of intensive mammalian cell bioreactor systems using magnetic resonance imaging and spectroscopy. (1998) (11)
- A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging. (2005) (10)
- Potent anti-metastatic activity of combretastatin-A4. (2001) (10)
- Hyperpolarized 13C spectroscopic imaging using single‐shot 3D sequences with unpaired adiabatic refocusing pulses (2018) (10)
- NMR Methods for Studying Enzyme Kinetics in Cells and Tissue (1987) (10)
- Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy (2021) (10)
- Sub‐minute kinetics of human red cell fumarase: 1H spin‐echo NMR spectroscopy and 13C rapid‐dissolution dynamic nuclear polarization (2018) (10)
- Centrifugal analysis of undiluted packed human erythrocyte lysates. Studies of the association of glyceraldehyde-phosphate dehydrogenase with the membrane fraction. (1983) (9)
- Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo. (2021) (9)
- Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer (2022) (9)
- 31P NMR measurements of the effects of unsaturated fatty acids on cellular phospholipid metabolism (1996) (9)
- p 300 regulates p 53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA p 21 levels (2004) (9)
- Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients (2021) (9)
- Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: A comparative study to DMXAA. (2009) (9)
- 1H/2H isotope exchange studies in intact erythrocytes. (1980) (8)
- Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR (2020) (8)
- Non-Invasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13 C MRI (2020) (8)
- Imaging breast cancer using hyperpolarized carbon-13 MRI. (2020) (7)
- Multiparametric MRI of early tumor response to immune checkpoint blockade in metastatic melanoma (2021) (7)
- 31P nuclear-magnetic resonance saturation transfer measurements of flux between inorganic phosphate and ATP in yeast cells over-producing phosphoglycerate kinase (1986) (7)
- Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal (2018) (7)
- Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-13C]Pyruvate Demonstrates Heterogeneity in Lactate Labeling: A Proof of Principle Study (2022) (7)
- Studies of metabolic control using NMR and molecular genetics (1997) (7)
- Proton NMR measurements of hydrogen exchange at the C‐3 position of 3‐hydroxybutyrate in suspensions of rat liver mitochondria (1983) (6)
- 13C magnetic resonance spectroscopy measurements with hyperpolarized [1‐13C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo (2015) (6)
- 18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography (2020) (5)
- Enzymology in vivo (1995) (5)
- Enzymology in vivo using NMR and molecular genetics (1993) (5)
- Dynamic nuclear polarisation: The future of imaging in oncology? (2017) (5)
- Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma ‐ bearing mice injected with 13 C ‐ and 14 C ‐ labeled pyruvate (2018) (4)
- Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal (2018) (4)
- Probing the properties of enzymes in vivo using NMR. (1995) (4)
- An NMR investigation of isotope exchange involving multiply labelled intermediates (1983) (4)
- Spectroscopic measurements of metabolic fluxes (2020) (4)
- Investigation of transcriptional responses of juvenile mouse bone marrow to power frequency magnetic fields. (2013) (4)
- Molecular Imaging of Apoptosis (2007) (3)
- Association of aldolase with the membranes in concentrated human erythrocyte lysates (1983) (3)
- Phospholipid Metabolism in Regenerating Rat Liver a 31Magenetic Resonance Spectroscopy Study (1988) (3)
- Integrated clonal analysis reveals circulating tumor DNA in urine and plasma of glioma patients (2019) (3)
- Determination of the PKa of a Hyperpolarized H13CO3- PH Probe (2012) (3)
- Short sequence-paper Uncoupling protein 2 from carp and zebra¢sh, ectothermic vertebrates (1999) (3)
- A combined n.m.r. and molecular biological approach to studying enzymes in vivo. (1991) (3)
- A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13C imaging (2020) (3)
- Increasing the sensitivity of hyperpolarized [15N2]urea detection by serial transfer of polarization to spin‐coupled protons (2020) (3)
- Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study (2022) (3)
- Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015. (2018) (2)
- Metabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model (2022) (2)
- Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [ 1 ‐ 13 C ] pyruvate and [ 1 ‐ 13 C ] lactate (2018) (2)
- Editorial commentary for the special issue: technological developments in hyperpolarized 13C imaging—toward a deeper understanding of tumor metabolism in vivo (2021) (2)
- Feasibility of metabolic imaging of hyperpolarized 13C-pyruvate in human breast cancer (2018) (2)
- Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent (2021) (2)
- Functional genomics via the metabolome Multivariate FANCY strategy for characterising genes of unknown function (2002) (2)
- A Combined NMR and Molecular Genetic Approach to Studying Enzymes in Vivo (1994) (2)
- Analysis of metabolic control In Vivo using molecular genetics (1996) (2)
- 1H n.m.r. studies of the kinetic properties expressed by erythrocyte enzymes in situ and in vitro (1983) (2)
- Erratum: Proton NMR analysis of plasma is a weak predictor of coronary artery disease (2006) (2)
- Nuclear Magnetic Resonance Methods of Monitoring Cell Metabolism (1999) (2)
- Experimental Approaches to Studying Enzymes in Vivo: The Application of Nuclear Magnetic Resonance Methods to Genetically Manipulated Organisms (1995) (2)
- 17: Magnetic resonance imaging of tumour metabolism (2014) (2)
- Comparison of 13C MRI of hyperpolarized [1‐13C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model (2021) (2)
- Author Correction: Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer (2022) (2)
- Deuterium MRSI of tumor cell death in vivo following oral delivery of 2H‐labeled fumarate (2022) (2)
- Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer (2021) (1)
- Genetic algorithm‐based optimization of pulse sequences (2021) (1)
- Monitoring the Performance of Tissue Engineering Bioreactors Using Magnetic Resonance Imaging and Spectroscopy (2005) (1)
- Probing The Cell Interior With NMR Spectroscopy (2000) (1)
- Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models (2017) (1)
- Metabolic Consequences of p 300 Gene Deletion in Human Colon Cancer Cells (2006) (1)
- Correction to: Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent (2021) (1)
- Chapter 9 Nuclear magnetic resonance studies of cell metabolism in vivo (1996) (1)
- OC-053 Lectin-Based Near infra-red Molecular Imaging for Dysplasia Detection in Barrett’s Oesophagus: An ex-vivo Study on Human Tissue (2016) (1)
- STUDIES OF TRANSPORT IN SUSPENSIONS OF WHOLE CELLS USING NMR (1981) (1)
- Lectins in Cervical Screening (2020) (1)
- Measuring tumor glycolytic flux in vivo using fast deuterium magnetic resonance imaging (2020) (1)
- Molecular Imaging of Cancer and the Implications for Pre-invasive Disease (2011) (1)
- Two paradigms of metabolic engineering applied to amino acid biosynthesis (2009) (1)
- Molecular imaging via novel application of fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett’s oesophagus (2011) (1)
- Research data supporting "Optoacoustic detection of early therapy-induced tumor cell death using a targeted imaging agent" (2017) (1)
- Labile photo-induced free radical in alpha-ketoglutaric acid: a universal endogenous polarizing agent for in vivo hyperpolarized 13C magnetic resonance. (2021) (1)
- Imaging Glioblastoma Response to Radiotherapy Using 2H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism (2022) (1)
- Detection of acute kidney injury using hyperpolarized [ 1 , 4-13 C 2 ] fumarate (2010) (1)
- An Investigation into the Nature of Intracellular Iron in Iron Overload (1988) (1)
- EP-2102: Correlating MRI radiomics with biology during therapy in cancer models: a tool for drug development? (2018) (1)
- Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy using a targeted imaging probe (2016) (1)
- Preclinical Development Detection of Tumor Response to a Vascular Disrupting Agent by Hyperpolarized 13 C Magnetic Resonance Spectroscopy (2010) (1)
- Abstract 1869: Improved image-guided surgical resection of glioblastoma with [18F]-fluoroethyltyrosine Cerenkov luminescence imaging (2017) (0)
- Imaging glycosylation in vivo using metabolic labeling and MRI (2015) (0)
- Molecular imaging via novel application of fluorescent lectins permits rapid endoscopic identification of dysplasia in barrett's oesophagus (2011) (0)
- Metabolic imaging with deuterium labeled substrates (2023) (0)
- Abstract 3600: Early detection of esophageal adenocarcinoma using near-infrared lectin-based imaging (2018) (0)
- Metabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides (2022) (0)
- Therapeutic fatty acid synthase inhibition can be monitored using 11C acetate pet in a xenograft model of prostate cancer (2013) (0)
- CBMT-33. VISUALIZING THE METABOLISM OF GLIOBLASTOMA PATIENT-DERIVED ORTHOTOPIC XENOGRAFTS BY MASS SPECTROMETRY IMAGING (2019) (0)
- Abstract 2853: Imaging tumor metabolism to guide treatment of breast cancer with drugs targeted at PI3K alpha (2017) (0)
- Abstract IA14: Imaging tumor metabolism with hyperpolarized13C-labeled cell substrates (2017) (0)
- Measurements of carbonic anhydrase activity in vivo using hyperpolarized 13C-magnetic resonance spectroscopy demonstrate its importance in pH regulation (2015) (0)
- Enzyme‐Catalyzed Exchange: Magnetization Transfer Measurements (2007) (0)
- Abstract 4116: Rapid imaging of tumor cell death in vivo using C2Am (2018) (0)
- Back Cover: Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging (Angew. Chem. Int. Ed. 4/2016) (2016) (0)
- Hyperpolarized 13C magnetic resonance spectroscopy detects early changes in tumor metabolism following treatment with the anti-angiogenic agent Bevacizumab (2011) (0)
- A NMR study of glucose and alanine metabolism by the beta cell lines RINm5F and BRIN-BD11. (2001) (0)
- A NMR study of nutrient metabolism in the pancreatic beta cell-line BRIN-BD11 (2002) (0)
- Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent (2021) (0)
- Early Response to Cyclophosphamide Treatment in a Myc-driven Lymphoma Model using Hyperpolarized 13C-Pyruvate and FDG-PET (2013) (0)
- The early detection of cancer. (1966) (0)
- Rücktitelbild: Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging (Angew. Chem. 4/2016) (2016) (0)
- Decision letter: Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice (2019) (0)
- Abstracts of the 26th international isotope society (UK group) symposium: Synthesis & applications of labelled compounds 2017 (2018) (0)
- clinical Proton M r s pectroscopy in central nervous s ystem Disorders 1 (2014) (0)
- Spectroscopic measurements of metabolic fluxes (2020) (0)
- C-labeled malate as a treatment response marker in a murine lymphoma model in vivo (2008) (0)
- Detecting tumor responses to treatment with magnetic resonance imaging (2008) (0)
- Book Review: Chemical Exchange Saturation Transfer Imaging: Advances and Applications (2017) (0)
- SP-0361: Imaging biology in the cancer patient (2015) (0)
- ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung (2020) (0)
- Abstract 2817: Metabolic heterogeneity in breast cancer integrative clusters to screen metabolic vulnerabilities for diagnosis and treatment response (2021) (0)
- Discovery of prognostic biomarkers from the prostate cancer membrane proteome using bioorthogonal chemistry (2019) (0)
- MALDI-MS and [11C] acetate PET imaging of lipid heterogeneity in non-small-cell lung cancer (2016) (0)
- Innovating Metabolic Biomarkers for Hyperpolarized NMR (2021) (0)
- Referee acknowledgement for 2018 (2019) (0)
- Abstract 15323: Comparison of in vitro [18]F-NaF Binding to Recovered Human Carotid Plaques After [18]F-NaF in vivo Clinical Imaging (2014) (0)
- Abstract SY18-02: Hyperpolarized MRI: An emerging technology for metabolic imaging of cancer (2011) (0)
- Assessment of the sensitivity of 2 H MR spectroscopy measurements of [2,3-2 H2 ]fumarate metabolism for detecting tumor cell death. (2023) (0)
- Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imaging (2010) (0)
- Gene reporters for magnetic resonance imaging. (2022) (0)
- NOVEL AI APPROACHES IN MEDICAL IMAGE INTERPRETATION (2019) (0)
- Characterization of full-length p53 aggregates and their kinetics of formation. (2022) (0)
- Hyperpolarised 13C magnetic resonance spectroscopic imaging (2021) (0)
- Nuclear Magnetic Resonance Methods for Monitoring Cell Growth and Metabolism in Intensive Bioreactors (2007) (0)
- Hyperpolarised [1-13C]-dehydroascorbic acid as a potential magnetic resonance imaging marker of pentose phosphate pathway activity (2013) (0)
- Studies of transport in suspensions of whole cells by using nuclear magnetic resonance (1980) (0)
- Assessing the tumour microenvironment and treatment response using hyperpolarised C-13 labelled cell substrates (2013) (0)
- Abstract 345: Somatic induction of bioluminescent lung tumors in mice. (2013) (0)
- Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13 C-labelled glucose (2012) (0)
- Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am (2023) (0)
- Correction to: Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent (2021) (0)
- Magnetic cells show the way home (2003) (0)
- Developing Pyruvate Decarboxylase (PDC) as a reporter gene for DNP NMRSI (2013) (0)
- Abstract LB-122: molecular imaging of early colorectal dysplasia using fluorescently-labeled lectins (2015) (0)
- Reply to ‘Assembling the brain trust: the multidisciplinary imperative in neuro-oncology’ (2019) (0)
- Differential localization ofthemRNAoftheM andBisoforms ofcreatine kinase inmyoblasts (1995) (0)
- Artefactual uncoupling following UCP3 expression in yeast mitochondria (2001) (0)
- 1080l: Potential Application of Lectins As Molecular Imaging Tools to Detect Dysplasia in Barrett's Oesophagus Endoscopically (2010) (0)
- 2156 Detection of early colorectal dysplasia using fluorescently-labeled lectins (2015) (0)
- Abstract CN01-02: Detecting tumor responses to treatment using magnetic resonance imaging and spectroscopy (2009) (0)
- Abstract 78: A novel orthotopic mammary epithelial cell (MEC) transplantation model of breast cancer formation (2014) (0)
- 13C Breast Coil with Dual Transmit and Eight Receive Channels for Metabolic Imaging with Hyperpolarized Compounds (2013) (0)
- 217 Detecting tumor responses to treatment using magnetic resonance imaging and hyperpolarized spectroscopy (2009) (0)
- Mobile lipids and apoptosis (2008) (0)
- 833 Monitoring the effects of therapeutic fatty acid synthase inhibition in prostate canecr using 11C acetate PET (2013) (0)
- measurements of hydrogen exchange at the C-3 3-hydroxybutyrate in suspensions of rat liver mitochondria (1983) (0)
- Imaging the healthy human brain with hyperpolarized 13C MRI (2018) (0)
- CBMT-13. UNRAVELLING METABOLISM OF GLIOBLASTOMA USING MASS SPECTROMETRY IMAGING (2018) (0)
- Proton NMR studies of intact cells (1982) (0)
- Abstract 4203: Non-invasive imaging of tumor cell death induced by a TRAILR2 agonist (2016) (0)
- Tissue Engineering of Meniscal Cartilage (2001) (0)
- In vivo reduction of Hyperpolarized [ 1-13 C ]-Dehydroascorbic Acid is affected by glucose transporter expression (2011) (0)
- T1912 Lectin Targeting of Glycan Alterations to Detect Dysplasia in Barrett's Esophagus (2009) (0)
- Abstract 2866: Volumetric optoacoustic imaging of tumor cell death using a targeted imaging agent (2017) (0)
- P magnetization transfer measurements of Pi-> ATP flux in exercising human muscle 1 2 (2015) (0)
- Frontispiece: Site‐Selective Modification of Proteins with Oxetanes (2017) (0)
- Molecular Imaging via Novel Application of Fluorescent Lectins Permits Rapid Endoscopic Identification of Dysplasia in Barrett's Esophagus (2011) (0)
- Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer (2022) (0)
- Abstract 447: Sensitive detection of ctDNA in low burden and ‘challenging’ cancers (2019) (0)
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