Kian Fan Chung

Q: What Schools Are Affiliated With Kian Fan Chung

Kian Fan Chung is affiliated with the following schools: Chang Gung University, University of Southampton, University of Bergen, Humboldt University of Berlin, University of Cologne, Imperial College London, University of Sydney, Charing Cross Hospital Medical School, University of California, San Francisco

Kian Fan Chung's AcademicInfluence.com Rankings

Kian Fan Chung

Philosophy

#2398

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#4111

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#562

World Rank

#1018

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Philosophy

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Kian Fan Chung's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma (2013) (2784)
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response (2000) (1869)
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. (2010) (1822)
Respiratory effects of exposure to diesel traffic in persons with asthma. (2007) (883)
Neutrophilic inflammation in severe persistent asthma. (1999) (880)
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. (2007) (876)
Inflammatory mediators of asthma: an update. (1998) (799)
Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations (2011) (772)
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. (1998) (716)
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. (2010) (687)
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. (2004) (620)
ERS guidelines on the assessment of cough (2007) (594)
Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action (2016) (573)
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction (2008) (547)
Prevalence, pathogenesis, and causes of chronic cough (2008) (530)
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression (2002) (496)
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. (2001) (481)
Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. (1998) (453)
Cytokines in asthma (1999) (438)
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. (2002) (411)
Inflammatory mediators and asthma. (1988) (405)
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort (2015) (400)
Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. (2007) (396)
Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. (1999) (378)
Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. (2007) (372)
Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. (2004) (371)
Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. (1998) (349)
Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI) (2010) (340)
Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks (2017) (337)
T helper type 17‐related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients (2009) (315)
Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline (2019) (307)
Expression and activity of histone deacetylases in human asthmatic airways. (2002) (302)
Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease (2015) (299)
Efficacy of a new once-daily long-acting inhaled β2-agonist indacaterol versus twice-daily formoterol in COPD (2010) (297)
Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. (2001) (296)
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. (1996) (296)
Airway inflammation after controlled exposure to diesel exhaust particulates. (2000) (290)
Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. (2008) (286)
EFFECT OF A GINKGOLIDE MIXTURE (BN 52063) IN ANTAGONISING SKIN AND PLATELET RESPONSES TO PLATELET ACTIVATING FACTOR IN MAN (1987) (285)
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. (2006) (279)
Bradykinin–evoked sensitization of airway sensory nerves: A mechanism for ACE–inhibitor cough (1996) (271)
Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. (2010) (269)
Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. (1997) (265)
Prevalence, risk factors, and management of asthma in China: a national cross-sectional study (2019) (264)
Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. (1998) (263)
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma (2008) (263)
Role of inflammation in the hyperreactivity of the airways in asthma. (1986) (262)
Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. (2014) (262)
Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. (2000) (260)
A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. (1997) (260)
Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. (1996) (259)
Expert opinion on the cough hypersensitivity syndrome in respiratory medicine (2014) (258)
Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. (1995) (257)
Predicting and evaluating response to omalizumab in patients with severe allergic asthma. (2007) (250)
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. (2004) (247)
T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED (2017) (246)
Parameters associated with persistent airflow obstruction in chronic severe asthma (2004) (242)
Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma. (1999) (240)
New targets for drug development in asthma (2008) (236)
Application of ’omics technologies to biomarker discovery in inflammatory lung diseases (2013) (236)
AMIODARONE AND THE THYROID (1979) (232)
Fundamentals of pulmonary drug delivery. (2003) (231)
Systems medicine and integrated care to combat chronic noncommunicable diseases (2011) (230)
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. (2008) (227)
Platelet-activating factor as a mediator of allergic disease. (1988) (223)
Targeting the interleukin pathway in the treatment of asthma (2015) (222)
Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. (2012) (221)
Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. (2003) (218)
U‐BIOPRED clinical adult asthma clusters linked to a subset of sputum omics (2017) (210)
Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. (1986) (210)
Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study (2017) (210)
Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. (1995) (209)
IL‐17‐induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen‐activated protein (MAP) kinases (2001) (208)
Stimulation of degranulation from human eosinophils by platelet-activating factor. (1989) (203)
p38 mitogen-activated protein kinase pathways in asthma and COPD. (2011) (200)
MicroRNA Expression Profiling in Mild Asthmatic Human Airways and Effect of Corticosteroid Therapy (2009) (199)
Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. (1987) (197)
Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids. (2002) (189)
Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma. (2012) (189)
Functional effects of the microbiota in chronic respiratory disease. (2019) (186)
Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages. (1998) (186)
Expression and release of interleukin-8 by human airway smooth muscle cells: inhibition by Th-2 cytokines and corticosteroids. (1998) (186)
Genome-wide association study to identify genetic determinants of severe asthma (2012) (184)
The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts (2015) (178)
Chronic cough as a neuropathic disorder. (2013) (174)
Modules, networks and systems medicine for understanding disease and aiding diagnosis (2014) (170)
A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response (2014) (168)
Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing (2016) (166)
Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. (2002) (166)
Increased circulating fibrocytes in asthma with chronic airflow obstruction. (2008) (165)
Glucocorticoid receptor localization in normal and asthmatic lung. (1996) (165)
Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. (2005) (164)
Expression of RANTES mRNA and protein in airways of patients with mild asthma. (1996) (163)
Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids (1998) (162)
Phosphodiesterase inhibitors in airways disease (2006) (162)
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. (2012) (161)
TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells (2010) (160)
Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. (1995) (159)
Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized brown-Norway rats. (1991) (157)
Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma (2009) (155)
Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. (2002) (155)
Integrated care pathways for airway diseases (AIRWAYS-ICPs) (2014) (155)
An integrative systems biology approach to understanding pulmonary diseases. (2010) (154)
Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies (2016) (153)
Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines. (1999) (153)
Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle. (2006) (152)
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer (2011) (151)
Management of chronic cough (2008) (150)
Cytokine inhibition in the treatment of COPD (2014) (149)
Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation? (2000) (149)
A Transcriptome‐driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U‐BIOPRED (2017) (149)
Inflammatory mediators in chronic obstructive pulmonary disease. (2005) (147)
Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough. (2011) (146)
Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma. (2013) (144)
Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma (2000) (142)
An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. (2013) (141)
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study (2019) (141)
Significance of thromboxane generation in ozone-induced airway hyperresponsiveness in dogs. (1985) (140)
Airway Microbiota in Severe Asthma and Relationship to Asthma Severity and Phenotypes (2016) (140)
Kinase inhibitors and airway inflammation. (2006) (140)
Allergen-Specific Th1 Cells Counteract Efferent Th2 Cell-Dependent Bronchial Hyperresponsiveness and Eosinophilic Inflammation Partly Via IFN-γ1 (2001) (137)
Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24 hours after allergen challenge. (2001) (137)
Antigen-induced airway hyperresponsiveness and pulmonary inflammation in allergic dogs. (1985) (135)
Sputum transcriptomics reveal upregulation of IL‐1 receptor family members in patients with severe asthma (2017) (135)
A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U‐BIOPRED Cohorts (2017) (135)
Nature of airway inflammation and remodeling in chronic cough. (2005) (133)
Randomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma (1990) (133)
Cytokines as targets in chronic obstructive pulmonary disease. (2006) (131)
Increased neutrophils and cytokines, TNF-α and IL-8, in induced sputum of non-asthmatic patients with chronic dry cough (1999) (130)
Inhaled corticosteroids as combination therapy with β-adrenergic agonists in airways disease: present and future (2009) (130)
Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. (1990) (128)
Mechanistic impact of outdoor air pollution on asthma and allergic diseases. (2015) (127)
Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects (1998) (126)
Importance of hedgehog interacting protein and other lung function genes in asthma. (2011) (125)
Models of chronic obstructive pulmonary disease (2004) (125)
ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle (2016) (124)
The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease. (2005) (124)
Alterations of the arginine metabolome in asthma. (2008) (122)
Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitized Brown-Norway rats. (1992) (121)
Interaction of ozone and allergen challenges on bronchial responsiveness and inflammation in sensitised guinea pigs. (1997) (120)
Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough (2004) (120)
Regular formoterol treatment in mild asthma. Effect on bronchial responsiveness during and after treatment. (1995) (119)
Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. (1990) (119)
Epithelial IL‐6 trans‐signaling defines a new asthma phenotype with increased airway inflammation (2019) (119)
Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. (2007) (118)
Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma. (2001) (118)
Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI. (2013) (117)
Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. (2001) (115)
Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. (2007) (114)
Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial (2016) (113)
Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung. (1996) (112)
IL4Rα Mutations Are Associated with Asthma Exacerbations and Mast Cell/IgE Expression (2007) (111)
The role of increased airway microvascular permeability and plasma exudation in asthma. (1990) (111)
Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. (2006) (110)
Role of c‐jun N‐terminal kinase in the induced release of GM‐CSF, RANTES and IL‐8 from human airway smooth muscle cells (2003) (110)
Ozone induction of cytokine‐induced neutrophil chemoattractant (CINC) and nuclear factor‐κb in rat lung: inhibition by corticosteroids (1996) (110)
A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. (2010) (109)
Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses (2021) (109)
Expression of heme oxygenase isoenzymes 1 and 2 in normal and asthmatic airways: effect of inhaled corticosteroids. (2000) (108)
Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity (2011) (108)
Inhibition of antigen-induced airway hyperresponsiveness by a thromboxane synthetase inhibitor (OKY-046) in allergic dogs. (1986) (106)
Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells. (1994) (106)
Opioid modulation of non‐cholinergic neural bronchoconstriction in guinea‐pig in vivo (1988) (106)
Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma (2012) (106)
Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment? (2017) (106)
Effect of inhaled corticosteroids on peripheral blood eosinophil counts and density profiles in asthma. (1993) (105)
Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma (2009) (104)
Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma. (2000) (103)
Steroid resistance in asthma: Mechanisms and treatment options (2008) (103)
Inflammatory mediators involved in antigen-induced airway microvascular leakage in guinea pigs. (1988) (103)
Induction of eotaxin expression and release from human airway smooth muscle cells by IL‐1β and TNFα: effects of IL‐10 and corticosteroids (1999) (102)
The stability of silver nanoparticles in a model of pulmonary surfactant. (2013) (102)
An inhaled steroid improves markers of airway inflammation in patients with mild asthma. (1998) (101)
Pulmonary Toxicity of Instilled Silver Nanoparticles: Influence of Size, Coating and Rat Strain (2015) (100)
Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study (2016) (100)
Cough : causes, mechanisms, and therapy (2003) (99)
Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease (2016) (98)
Generation of oxygen free radicals from blood eosinophils from asthma patients after stimulation with PAF or phorbol ester. (1990) (98)
Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle (2005) (98)
Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD (2013) (98)
Safety of bronchial thermoplasty in patients with severe refractory asthma. (2013) (97)
Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling. (1999) (97)
Is diet partly responsible for differences in COVID-19 death rates between and within countries? (2020) (96)
Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes (2017) (95)
Sleep quality and asthma control and quality of life in non-severe and severe asthma (2012) (94)
Ozone-induced bronchial hyperresponsiveness in the rat is not accompanied by neutrophil influx or increased vascular permeability in the trachea. (1988) (94)
Regulation of TGF-β1-induced connective tissue growth factor expression in airway smooth muscle cells (2004) (93)
Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy (2006) (93)
Mesenchymal stem cells alleviate oxidative stress–induced mitochondrial dysfunction in the airways (2017) (92)
Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD (2009) (92)
Pathway discovery using transcriptomic profiles in adult‐onset severe asthma (2017) (91)
Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. (1991) (91)
RAGE: a new frontier in chronic airways disease (2012) (91)
Effect of inhaled l-arginine on exhaled nitric oxide in normal and asthmatic subjects (1998) (90)
Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma. (2005) (90)
Neuropeptide Y (NPY). (2004) (90)
The effects of activated eosinophils and neutrophils on guinea pig airway epithelium in vitro. (1990) (90)
Corticosteroid Inhibition of Growth-Related Oncogene Protein-α via Mitogen-Activated Kinase Phosphatase-1 in Airway Smooth Muscle Cells1 (2007) (90)
Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle (2017) (89)
Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-γ and TNF-α and regulation by TGF-β and corticosteroids (2004) (89)
Beta2-Adrenergic Receptors on Eosinophils: Binding and Functional Studies (1990) (88)
Tumor necrosis factor-induced interleukin-8 expression in cultured human airway epithelial cells. (1994) (88)
Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology (2019) (87)
Impaired macrophage phagocytosis of bacteria in severe asthma (2014) (87)
Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats (1999) (87)
Airway obstruction and bronchial hyperresponsiveness in left ventricular failure and mitral stenosis. (1991) (86)
Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways. (1991) (86)
Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice (2000) (86)
New treatments for severe treatment-resistant asthma: targeting the right patient. (2013) (86)
Leukotriene receptor antagonists and biosynthesis inhibitors: potential breakthrough in asthma therapy. (1995) (85)
Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK) (2015) (85)
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease (2005) (84)
MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients (2009) (84)
Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung (2002) (83)
Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat. (1996) (83)
Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells. (2011) (82)
Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies. (2001) (82)
Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125. (2005) (82)
Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport. (2004) (81)
Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma (2019) (80)
Post-Transcriptional Regulation of Bradykinin B1 and B2 Receptor Gene Expression in Human Lung Fibroblasts by Tumor Necrosis Factor-α: Modulation by Dexamethasone (2000) (80)
Long-acting beta 2-adrenoceptor agonists: a new perspective in the treatment of asthma. (1991) (80)
IL-22 suppresses IFN-γ-mediated lung inflammation in asthmatic patients. (2013) (79)
Inflammatory biomarkers in airways of patients with severe asthma compared with non‐severe asthma (2009) (79)
Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A. (2008) (79)
Asthma Is More Severe in Older Adults (2015) (78)
Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma. (2012) (78)
Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program. (2013) (78)
Health effects of real-world exposure to diesel exhaust in persons with asthma. (2009) (77)
Validation of the Anti-Inflammatory Properties of Small-Molecule IκB Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle (2006) (77)
Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: an open-label study. (2008) (77)
Regulation of human lung epithelial cell numbers by diesel exhaust particles (2006) (77)
Distribution of Respiratory Mucin Proteins in Human Nasal Mucosa (2003) (77)
Effect of theophylline and adenosine on eosinophil function. (1989) (77)
Effects of Prostaglandin E2 and cAMP Elevating Drugs on GM-CSF Release by Cultured Human Airway Smooth Muscle Cells (2001) (76)
Platelet-activating factor in inflammation and pulmonary disorders. (1992) (76)
Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils. (1988) (76)
Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs. (1990) (76)
Cardio- and cerebrovascular safety of indacaterol vs formoterol, salmeterol, tiotropium and placebo in COPD. (2011) (76)
Transforming growth factor-β and nuclear factor E2–related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma. (2011) (76)
No effect of inhaled budesonide on the response to inhaled ozone in normal subjects. (2000) (75)
Effect of CP-96,345, a non-peptide NK1 receptor antagonist, against substance P-, bradykinin- and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig. (1993) (74)
Pathophysiology and clinical presentations of cough. (1996) (74)
Glucocorticoids reverse IL‐1β‐induced impairment of β‐adrenoceptor‐mediated relaxation and up‐regulation of G‐protein‐coupled receptor kinases (2002) (73)
Neutrophil-Derived Elastase Induces TGF-β1 Secretion in Human Airway Smooth Muscle via NF-κB Pathway (2006) (72)
Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease (2020) (71)
Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. (1995) (71)
A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. (2011) (71)
Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS (2005) (71)
T-cells subsets and activation in bronchial mucosa of sensitized Brown-Norway rats after single allergen exposure. (1995) (70)
Role of non-coding RNAs in maintaining primary airway smooth muscle cells (2014) (70)
Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema (2018) (70)
Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats. (2003) (70)
Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. (2002) (69)
Pharmacological studies of the mechanism and function of interleukin-1β-induced miRNA-146a expression in primary human airway smooth muscle (2010) (69)
Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage. (1991) (69)
Nonadrenergic bronchodilator mechanisms in normal human subjects in vivo. (1988) (69)
Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model. (2019) (68)
Predicting Intermediate Phenotypes in Asthma Using Bronchoalveolar Lavage‐Derived Cytokines (2010) (68)
IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. (2007) (67)
Eosinophils adhere to and stimulate replication of lung fibroblasts ‘in vitro’ (1991) (67)
Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619. (1985) (67)
Corticosteroid suppression of lipoxin A4 and leukotriene B4from alveolar macrophages in severe asthma (2010) (66)
Safety of investigative bronchoscopy in the Severe Asthma Research Program. (2011) (66)
Allergen‐induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N‐terminal kinase (2003) (66)
Identifying patients at risk for severe exacerbations of asthma: development and external validation of a multivariable prediction model (2016) (66)
Inhibition of inducible nitric oxide synthase expression by interleukin‐4 and interleukin‐13 in human lung epithelial cells (1996) (66)
Attenuation of Ozone-Induced Airway Inflammation and Hyper-Responsiveness by c-Jun NH2 Terminal Kinase Inhibitor SP600125 (2007) (66)
Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness. (1990) (65)
Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway caliber. (1982) (65)
Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays. (2004) (65)
Determinants of exhaled breath condensate pH in a large population with asthma. (2011) (65)
Effect of Transforming Growth Factor-β Receptor I Kinase Inhibitor 2,4-Disubstituted Pteridine (SD-208) in Chronic Allergic Airway Inflammation and Remodeling (2006) (65)
The “Iron”‐y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease (2017) (64)
Questions about inhaled β2-adrenoceptor agonists in asthma (1992) (64)
Airway hyperresponsiveness is associated with inflammatory cell infiltration in allergic brown-Norway rats. (1992) (64)
Impacts of a nanosized ceria additive on diesel engine emissions of particulate and gaseous pollutants. (2013) (64)
A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model. (2014) (64)
Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma (2019) (64)
Expression of Th‐2 cytokines interleukin‐4 and −5 and of Th‐1 cytokine interferon‐γ in ovalbumin‐exposed sensitized Brown‐Norway rats (1996) (63)
Precision medicine for the discovery of treatable mechanisms in severe asthma (2019) (63)
IL-17-high asthma with features of a psoriasis immunophenotype. (2019) (62)
Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma. (2002) (62)
Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma. (1989) (62)
Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophages. (2003) (62)
Ketotifen inhibits the cutaneous but not the airway responses to platelet-activating factor in man. (1988) (62)
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. (2006) (61)
Contribution of bradykinin B(1) and B(2) receptors in allergen-induced bronchial hyperresponsiveness. (1999) (61)
Sputum microbiota in severe asthma patients: Relationship to eosinophilic inflammation. (2017) (61)
Effect of interleukin-1β on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats (1994) (61)
Role of cytokine-induced neutrophil chemoattractant (CINC) in ozone-induced airway inflammation and hyperresponsiveness. (1997) (61)
GRO-α regulation in airway smooth muscle by IL-1β and TNF-α: Role of NF-κB and MAP kinases (2006) (60)
Regional and time-dependent effects of inflammatory mediators on airway microvascular permeability in the guinea pig. (1989) (60)
Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features. (2005) (60)
Defining Phenotypes in Asthma: A Step Towards Personalized Medicine (2014) (59)
Approach to chronic cough: the neuropathic basis for cough hypersensitivity syndrome. (2014) (59)
Airway hyperresponsiveness, elevation of serum-specific IgE and activation of T cells following allergen exposure in sensitized Brown-Norway rats. (1995) (59)
Role of Nitric Oxide in Chronic Allergen-Induced Airway Cell Proliferation and Inflammation (2003) (59)
Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. (1993) (58)
Personal strategies to minimise effects of air pollution on respiratory health: advice for providers, patients and the public (2020) (58)
Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-gamma and TNF-alpha and regulation by TGF-beta and corticosteroids. (2004) (58)
Impaired nuclear translocation of the glucocorticoid receptor in corticosteroid-insensitive airway smooth muscle in severe asthma. (2015) (58)
Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects. (1989) (57)
Difficult asthma. (1989) (57)
Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism. (2013) (57)
Nonadrenergic, noncholinergic airway inhibitory nerves. (1992) (57)
Proliferation of airway epithelium after ozone exposure: effect of apocynin and dexamethasone. (1998) (56)
IL-4 and IL-13 Form a Negative Feedback Circuit with Surfactant Protein-D in the Allergic Airway Response1 (2006) (56)
Airway smooth muscle inflammation is regulated by microRNA‐145 in COPD (2016) (56)
Perspectives of patients and healthcare professionals on mHealth for asthma self-management (2017) (56)
Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database (2004) (55)
Aryl hydrocarbon receptor activation by diesel exhaust particles mediates epithelium‐derived cytokines expression in severe allergic asthma (2018) (55)
Alveolar macrophage-induced suppression of peripheral blood mononuclear cell responsiveness is reversed by in vitro allergen exposure in bronchial asthma. (1994) (55)
The heterogeneity of chronic cough: a case for endotypes of cough hypersensitivity. (2018) (55)
Outdoor air pollution and respiratory health in Asia (2011) (55)
Precision medicine in asthma: linking phenotypes to targeted treatments (2018) (55)
Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. (1988) (55)
Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness. (2006) (55)
Severe asthma: definition and mechanisms (2001) (55)
Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial (2020) (54)
Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol. (1993) (54)
Relationship between free and total malondialdehyde, a well-established marker of oxidative stress, in various types of human biospecimens. (2018) (53)
The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution. (2018) (53)
Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells. (2005) (53)
Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA (2016) (52)
Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis (2018) (52)
Chromosome 17q21 SNP and Severe Asthma (2010) (52)
Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology (2010) (52)
Characterization of platelet‐activating factor‐induced elevation of cytosolic free calcium concentration in eosinophils (1989) (51)
Bronchial inflammation and bacterial load in stable COPD is associated with TLR4 overexpression (2017) (50)
Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (2016) (49)
Vitamin D Metabolism is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease. (2020) (49)
Expression of inducible nitric oxide synthase mRNA in Brown Norway rats exposed to ozone: effect of dexamethasone. (1995) (49)
Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema. (1990) (48)
Increased sensitivity of the cough reflex in progressive systemic sclerosis patients with interstitial lung disease. (1998) (48)
Bromodomain and Extraterminal Proteins Suppress NF-E2–Related Factor 2–Mediated Antioxidant Gene Expression (2014) (48)
Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study. (2020) (48)
Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages. (1995) (48)
Capsaicin-induced bronchodilation in mild asthmatic subjects: possible role of nonadrenergic inhibitory system. (1989) (48)
Fibrocyte trafficking in patients with chronic obstructive asthma and during an acute asthma exacerbation. (2015) (47)
Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. (2010) (47)
Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness (2019) (47)
Addressing unmet needs in understanding asthma mechanisms (2017) (47)
Effects of prolonged repeated exposure to ovalbumin in sensitized brown Norway rats. (1994) (47)
Stem cell therapies for chronic obstructive pulmonary disease: current status of pre-clinical studies and clinical trials. (2018) (47)
Link between environmental air pollution and allergic asthma: East meets West. (2015) (46)
A thromboxane mimetic, U-46619, produces plasma exudation in airways of the guinea pig. (1992) (46)
Density heterogeneity of eosinophil leucocytes: induction of hypodense eosinophils by platelet-activating factor. (1989) (46)
Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. (2005) (45)
Role of microRNAs in allergic asthma: present and future (2015) (45)
Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases (2019) (45)
Stratification of asthma phenotypes by airway proteomic signatures. (2019) (44)
PAF closely mimics pathology of asthma (1987) (44)
How to diagnose and phenotype asthma. (2012) (44)
Complete inhibition of allergic airway inflammation and remodelling in quadruple IL‐4/5/9/13−/− mice (2007) (44)
Effect of an inhibitor of Jun N‐terminal protein kinase, SP600125, in single allergen challenge in sensitized rats (2004) (44)
Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. (2004) (44)
Influence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects. (1988) (44)
BET Bromodomains Regulate Transforming Growth Factor-β-induced Proliferation and Cytokine Release in Asthmatic Airway Smooth Muscle* (2015) (43)
How variability in clinical phenotypes should guide research into disease mechanisms in asthma. (2013) (43)
Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction (2016) (43)
Characteristics and treatment regimens across ERS SHARP severe asthma registries (2019) (43)
Platelet-activating factor causes ventilation-perfusion mismatch in humans. (1994) (43)
Combination Therapy of Long-Acting β2-Adrenoceptor Agonists and Corticosteroids for Asthma (2004) (43)
Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man. (1989) (43)
Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea‐pig and platelet aggregation in man (1988) (42)
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies (2020) (42)
Drugs to suppress cough (2005) (42)
Exacerbations in Adults with Asthma: A Systematic Review and External Validation of Prediction Models. (2018) (42)
The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD (2016) (42)
Future Risks in Patients With Severe Asthma (2019) (42)
Is TRPV1 a useful target in respiratory diseases? (2008) (42)
Overcoming Reduced Glucocorticoid Sensitivity in Airway Disease (2010) (42)
Kyphoscoliosis and bronchial torsion. (1997) (42)
Ozone-induced airway hyperresponsiveness: role of superoxide anions, NEP, and BK receptors. (1995) (42)
Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma. (2013) (42)
Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage. (1991) (41)
Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects. (1988) (41)
Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha: modulation by dexamethasone. (2000) (41)
Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD (2015) (41)
Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma (2015) (41)
Contribution of intercellular-adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised brown-Norway rats. (1994) (40)
Effects of N-Acetylcysteine in Ozone-Induced Chronic Obstructive Pulmonary Disease Model (2013) (40)
alpha4 integrin-dependent eotaxin induction of bronchial hyperresponsiveness and eosinophil migration in interleukin-5 transgenic mice. (1999) (40)
Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study (2016) (40)
Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma (2001) (40)
New Drugs: Respiratory and allergic disease—I (1988) (40)
Leukotriene antagonists and Churg-Strauss syndrome: the smoking gun. (1999) (40)
Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. (1992) (40)
Interleukin 13 inhibits macrophage inflammatory protein-1 alpha production from human alveolar macrophages and monocytes. (1996) (40)
Prostaglandins E2 and F2alpha reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway caliber changes. (1998) (39)
Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. (2006) (39)
Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity (2006) (39)
Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig (2007) (39)
Peripheral airways obstruction on high-resolution computed tomography in chronic severe asthma. (1998) (39)
Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague–Dawley rats (2016) (39)
Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation. (2008) (39)
Salbutamol reduces pulmonary neutrophil sequestration of platelet-activating factor in humans. (1996) (39)
Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy. (2001) (39)
Assessment and measurement of cough: the value of new tools. (2002) (39)
Bronchial hyperreactivity after inhalation of trimellitic anhydride dust in guinea pigs after intradermal sensitization to the free hapten. (1992) (39)
Mitogen‐activated protein kinase signalling pathways in IL‐1β‐dependent rat airway smooth muscle proliferation (2004) (39)
Inhaled platelet-activating factor worsens gas exchange in mild asthma. (1994) (38)
Currently Available Cough Suppressants for Chronic Cough (2007) (38)
Therapy for cough: active agents. (2002) (38)
Metabolic re-patterning in COPD airway smooth muscle cells (2017) (38)
TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5) (2019) (38)
Measurement of cough (2006) (38)
Evaluation of Selective Prostaglandin E2 (PGE2) Receptor Agonists as Therapeutic Agents for the Treatment of Asthma (2005) (38)
Mechanisms of airway narrowing in acute pulmonary oedema in dogs: influence of the vagus and lung volume. (1983) (38)
Pathophysiological mechanisms of asthma (2001) (38)
Effect of topical capsaicin on the cutaneous responses to inflammatory mediators and to antigen in man. (1989) (38)
Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12-18 months. (2020) (38)
Dexamethasone inhibits ozone‐induced gene expression of macrophage inflammatory protein‐2 in rat lung (1995) (37)
Severe acute respiratory syndrome: global initiatives for disease diagnosis (2003) (37)
Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. (1994) (37)
Heme oxygenase-1 induction and exhaled markers of oxidative stress in lung diseases (2001) (37)
EMMPRIN (CD147) regulation of MMP‐9 in bronchial epithelial cells in COPD (2011) (37)
Role of inflammatory mediators in asthma. (1992) (37)
A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen‐exposed rat (2001) (37)
GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases. (2006) (36)
Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study (2020) (36)
Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma? (2017) (36)
Airway inflammation and remodelling changes in patients with chronic cough: do they tell us about the cause of cough? (2004) (36)
Attenuation of inhaled allergen-induced airway microvascular leakage and airflow obstruction in guinea pigs by a 5-lipoxygenase inhibitor (A-63162). (1991) (36)
Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by Gram-positive and Gram-negative bacteria in human airway smooth muscle cells (2008) (36)
Loop diuretics and asthma. (1992) (36)
Acute Respiratory Barrier Disruption by Ozone Exposure in Mice (2019) (36)
Hydrogen sulfide as a potential biomarker of asthma (2014) (36)
Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study (2014) (36)
Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea pigs (1992) (35)
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages (2001) (35)
Transcriptional Effects of Ozone and Impact on Airway Inflammation (2019) (35)
Regulation of Wnt4 in chronic obstructive pulmonary disease (2013) (35)
Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. (2012) (35)
Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone. (2002) (35)
Ceramide induction of COX-2 and PGE(2) in pulmonary A549 cells does not involve activation of NF-kappaB. (2000) (35)
Compliance with an oral asthma medication: a pilot study using an electronic monitoring device. (2000) (35)
Differential expression of IL‐10 receptor by epithelial cells and alveolar macrophages (2004) (35)
Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma (2017) (35)
Bradykinin-induced airway microvascular leakage is potentiated by captopril and phosphoramidon. (1991) (35)
Capsaicin cough sensitivity in bronchiectasis (2006) (35)
ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions (2019) (35)
Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells (2016) (34)
Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma. (2015) (34)
Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification (2015) (34)
Chronic cough and cough hypersensitivity syndrome. (2016) (34)
Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough (2019) (34)
Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation. (2009) (34)
Diagnosis and management of chronic persistent dry cough. (1996) (34)
Semantics and types of cough. (2009) (34)
Prostaglandin F2α increases responsiveness of pulmonary airways in dogs (1984) (33)
Effect of frusemide on cough responses to chloride-deficient solution in normal and mild asthmatic subjects. (1993) (33)
The investigation of severe asthma to define phenotypes (2012) (33)
Evidence for neuropathic processes in chronic cough. (2015) (33)
High-resolution analytical electron microscopy reveals cell culture media-induced changes to the chemistry of silver nanowires. (2013) (33)
Activation of p38 mitogen‐activated protein kinase in ovalbumin and ozone‐induced mouse model of asthma (2013) (33)
Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness. (2015) (33)
Induction of macrophage inflammatory protein 2 gene expression by interleukin 1 beta in rat lung. (1995) (33)
Longitudinally Stable, Clinically Defined Clusters of Patients with Asthma Independently Identified in the ADEPT and U-BIOPRED Asthma Studies. (2016) (32)
Respiratory disease mortality in the United Kingdom compared with EU15+ countries in 1985-2015: observational study (2018) (32)
Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP‐10 and MET (2019) (32)
TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD (2017) (32)
Molecular mechanisms of oxidative stress in asthma. (2021) (32)
Glucocorticoids reverse IL-1beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases. (2002) (32)
Potential Role of the Lung Microbiome in Shaping Asthma Phenotypes (2017) (32)
Expression of transforming growth factor-β (TGF-β) in chronic idiopathic cough (2009) (32)
Modeling population exposures to silver nanoparticles present in consumer products (2014) (32)
Postnasal drip and chronic cough: An open interventional study. (2009) (31)
Identification and expression of a new type II transmembrane protein in human mast cells. (2005) (31)
IL-17A Modulates Oxidant Stress-Induced Airway Hyperresponsiveness but Not Emphysema (2013) (31)
New immunological approaches and cytokine targets in asthma and allergy. (2000) (31)
XXIV World Allergy Congress 2015 (2016) (31)
Treatable traits in the European U‐BIOPRED adult asthma cohorts (2018) (30)
Clinical phenotypes of asthma should link up with disease mechanisms (2015) (30)
Comparing biologicals and small molecule drug therapies for chronic respiratory diseases: An EAACI Taskforce on Immunopharmacology position paper (2019) (30)
Capsaicin cough sensitivity in smokers with and without airflow obstruction. (2009) (30)
Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13 (2008) (30)
Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice. (2016) (30)
Inflammatory biomarkers in severe asthma (2012) (30)
Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies (2019) (30)
Neutrophilic asthma: a distinct target for treatment? (2016) (30)
Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program. (2014) (30)
Clinical cough VI: the need for new therapies for cough: disease-specific and symptom-related antitussives. (2009) (30)
Bronchoconstriction and airway microvascular leakage in guinea pigs sensitized with trimellitic anhydride. (1992) (30)
Increased progenitor cell proliferation in the peripheral blood of patients with bronchial asthma: the role of nitric oxide. (1999) (30)
The complementary role of glucocorticosteroids and long‐acting β‐adrenergic agonists (1998) (29)
Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD). (2010) (29)
Future treatments of allergic diseases and asthma. (2000) (29)
Effect of prior bronchoconstriction on the airway response to histamine in normal subjects. (1984) (29)
Personalised medicine in asthma: time for action (2017) (29)
Chronic Cough 1 Prevalence, pathogenesis, and causes of chronic cough (2008) (29)
Toward personalization of asthma treatment according to trigger factors (2020) (29)
Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats (2017) (29)
Role of thromboxane A2 in airway microvascular leakage induced by inhaled platelet-activating factor. (1991) (29)
International European Respiratory Society/American Thoracic Society guidelines on severe asthma (2014) (29)
Interleukin‐5 in growth and differentiation of blood eosinophil progenitors in asthma: effect of glucocorticoids (2001) (29)
Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea‐pigs (1992) (28)
Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control (2013) (28)
Protective effect of loop diuretics, piretanide and frusemide, against sodium metabisulphite-induced bronchoconstriction in asthma. (1992) (28)
Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15. (2007) (28)
NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome. (2015) (28)
Silver nanowire interactions with primary human alveolar type-II epithelial cell secretions: contrasting bioreactivity with human alveolar type-I and type-II epithelial cells. (2015) (28)
Corticosteroid modulation of immunoglobulin expression and B‐cell function in COPD (2016) (28)
Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium (2020) (28)
Cysteinyl-leukotrienes partly mediate eotaxin-induced bronchial hyperresponsiveness and eosinophilia in IL-5 transgenic mice. (1999) (27)
Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats (2003) (27)
Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids. (1999) (27)
Inter-disease Comparison of Research Quantity and Quality: Bronchial Asthma and Chronic Obstructive Pulmonary Disease (2009) (26)
An overview of methods of fine and ultrafine particle collection for physicochemical characterisation and toxicity assessments. (2020) (26)
Delivering effective asthma care--how do we implement asthma guidelines? (2000) (26)
Clinical management of severe therapy-resistant asthma (2017) (26)
Targeted omics and systems medicine: personalising care. (2014) (26)
Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central London. (2018) (26)
Contribution of upregulated airway endothelin-1 expression to airway smooth muscle and epithelial cell DNA synthesis after repeated allergen exposure of sensitized Brown-Norway rats. (2000) (26)
Effective antitussives for the cough patient: an unmet need. (2007) (26)
Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity (2015) (26)
Role of nitric oxide and superoxide anions in interleukin-1 beta-induced airway hyperresponsiveness to bradykinin. (1994) (26)
Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells. (2016) (26)
Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma. (2004) (25)
Effects of aerosolised substance P on lung resistance in guinea‐pigs: a comparison between inhibition of neutral endopeptidase and angiotensin‐converting enzyme (1990) (25)
RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol. (2001) (25)
Difficult-to-Treat Severe Asthma (2011) (25)
Pharmacological modulation of inhaled sodium metabisulphite‐induced airway microvascular leakage and bronchoconstriction in the guinea‐pig (1992) (25)
A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial (2018) (25)
Glucocorticoid insensitivity as a future target of therapy for chronic obstructive pulmonary disease (2010) (25)
Modeling physicochemical interactions affecting in vitro cellular dosimetry of engineered nanomaterials: application to nanosilver (2014) (25)
IL‐6 pathway upregulation in subgroup of severe asthma is associated with neutrophilia and poor lung function (2018) (25)
Involvement of haemoxygenase-1 in ozone-induced airway inflammation and hyperresponsiveness. (2000) (24)
Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa (2005) (24)
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma (2020) (24)
Cough hypersensitivity syndrome: clinical measurement is the key to progress (2015) (24)
Cutaneous mast cell heterogeneity: response to antigen in atopic dogs. (1986) (24)
Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma (2019) (24)
Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation. (1997) (24)
Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products. (1994) (24)
Involvement of tachykinin receptors (NK1 and NK2) in sodium metabisulfite-induced airway effects. (1994) (24)
Immune Response to Mycobacterium tuberculosis Infection in the Parietal Pleura of Patients with Tuberculous Pleurisy (2011) (24)
The Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) ERS Clinical Research Collaboration: a new dawn in asthma research (2018) (24)
Repeated allergen inhalation induces cytoskeletal remodeling in smooth muscle from rat bronchioles. (2007) (23)
A computational framework for complex disease stratification from multiple large-scale datasets (2018) (23)
Detection of bronchiectasis by high-resolution computed tomography in the yellow nail syndrome. (1991) (23)
Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation (2018) (23)
Low‐dose theophylline does not exert its anti‐inflammatory effects in mild asthma through upregulation of interleukin‐10 in alveolar macrophages (2001) (23)
Effect of 5-HT1A receptor agonist, 8-OH-DPAT, on cough responses in the conscious guinea pig. (1997) (23)
Inhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects. (1994) (23)
Activation of NF‐κB transcription factor in asthma death (2009) (23)
Peptide mediator effects on bronchial blood velocity and lung resistance in conscious sheep. (1992) (22)
Carboxylation of multiwalled carbon nanotubes reduces their toxicity in primary human alveolar macrophages (2016) (22)
Effect of formoterol, a long-lasting beta 2-adrenoceptor agonist, against methacholine-induced bronchoconstriction. (1990) (22)
Peptidase modulation of noncholinergic vagal bronchoconstriction and airway microvascular leakage. (1991) (22)
MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan. (2010) (22)
Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity (2019) (22)
Difficult asthma. (1989) (22)
Capsaicin pretreatment does not inhibit allergen‐induced airway microvascular leakage in guinea pig (1991) (22)
Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD (2015) (22)
The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma. (1998) (21)
STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects (2012) (21)
Cough: setting the scene. (2009) (21)
Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM2.5 in mice (2020) (21)
Managing severe asthma in adults: lessons from the ERS/ATS guidelines (2015) (21)
Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation (2019) (21)
Effectiveness of myAirCoach: a mHealth self-management system in asthma. (2020) (21)
Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease. (2013) (21)
Mucus and fatal asthma. (2004) (20)
Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma. (1995) (20)
Pharmacology and Therapeutics of Cough (2010) (20)
Inhibition of ozone-induced lung neutrophilia and nuclear factor-kappaB binding activity by vitamin A in rat. (1999) (20)
Inhibition of chemokine production from human airway smooth muscle cells by fluticasone, budesonide and beclomethasone. (2004) (20)
Sputum-to-serum hydrogen sulfide ratio in COPD (2014) (20)
Summary of recommendations for the design of clinical trials and the registration of drugs used in the treatment of asthma (2002) (20)
Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant. (2015) (20)
Salbutamol inhibits pulmonary effects of platelet activating factor in man. (1995) (20)
Asthma Phenotypes Defined From Parameters Obtained During Recovery From a Hospital-Treated Exacerbation. (2018) (19)
Diagnosis and Management of Severe Asthma (2018) (19)
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma (2020) (19)
Comment on: International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma (2014) (19)
American College of Chest Physicians' cough guidelines (2006) (19)
Release of airborne particles and Ag and Zn compounds from nanotechnology-enabled consumer sprays: Implications for inhalation exposure (2017) (19)
Lipid-laden bronchoalveolar macrophages in asthma and chronic cough. (2014) (19)
Methacholine dose-response curves in normal and asthmatic man: effect of starting conductance and pharmacological antagonism. (1984) (19)
Cough as a symptom and a disease entity: scientometric analysis and density-equalizing calculations. (2009) (19)
Prostaglandins mediate bradykinin-induced reduction of exhaled nitric oxide in asthma. (1999) (19)
Fluticasone, but not salmeterol, reduces cigarette smoke-induced production of interleukin-8 in human airway smooth muscle. (2008) (19)
Protective effects of VGX‐1027 in PM2.5‐induced airway inflammation and bronchial hyperresponsiveness (2019) (19)
Immune modulation via T regulatory cell enhancement: Disease‐modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO) (2020) (19)
No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux (2005) (19)
Nitric Oxide Sustains IL-1β Expression in Human Dendritic Cells Enhancing Their Capacity to Induce IL-17–Producing T-Cells (2015) (19)
The small airway epithelium as a target for the adverse pulmonary effects of silver nanoparticle inhalation (2018) (19)
CSF3R/CD114 mediates infection-dependent transition to severe asthma. (2019) (18)
Avoiding artefacts during electron microscopy of silver nanomaterials exposed to biological environments (2016) (18)
Role of neutral endopeptidase in bronchial hyperresponsiveness to bradykinin induced by IL-1 beta. (1995) (18)
Integrin binding characteristics of the disintegrin-like domain of ADAM-15 (2006) (17)
The effect of anion transport inhibitors and extracellular Cl- concentration on eosinophil respiratory burst activity. (1992) (17)
Advances in mechanisms and management of chronic cough: The Ninth London International Cough Symposium 2016. (2017) (17)
Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD (2014) (17)
Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma. (1999) (17)
Mitochondrial dysfunction in airways and quadriceps muscle of patients with chronic obstructive pulmonary disease (2020) (17)
AsthmaMap: An expert‐driven computational representation of disease mechanisms (2018) (17)
Regulation of protease-activated receptor-1 in mononuclear cells by neutrophil proteases. (2003) (17)
Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats. (1994) (17)
Allergen-induced airway hyperresponsiveness in Brown-Norway rat: role of parasympathetic mechanisms. (1993) (17)
Oxidative/nitrosative stress selectively altered A2B adenosine receptors in chronic obstructive pulmonary disease (2010) (17)
A Comparison of Low-Dose Inhaled Budesonide Plus Theophylline and High-Dose Inhaled Budesonide for Moderate Asthma (1998) (17)
Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study. (1999) (17)
Cough: meeting the needs of a growing field (2005) (17)
The airway smooth muscle cell: a major contributor to asthma? (2000) (17)
The Objective Assessment of Cough Frequency in Bronchiectasis (2017) (17)
Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury (2014) (17)
Sputum macrophage diversity and activation in asthma: Role of severity and inflammatory phenotype (2020) (17)
Pharmacology of corticosteroids. (1998) (17)
Bronchoconstriction induced by inhaled sodium metabisulfite in the guinea pig. Effect of capsaicin pretreatment and of neutral endopeptidase inhibition. (1990) (17)
Effect of thiazide diuretics against neurally mediated contraction of guinea pig airways. Contribution of carbonic anhydrase. (1993) (17)
RETRACTED ARTICLE: The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide (2018) (17)
Dupilumab: a potential new treatment for severe asthma (2016) (17)
Airway and cough responsiveness and exhaled nitric oxide in non-smoking patients with stable chronic heart failure. (1996) (16)
Individual cytokines contributing to asthma pathophysiology: valid targets for asthma therapy? (2003) (16)
Ultrastructural characterization of platelet-activating factor-stimulated human eosinophils from patients with asthma. (1993) (16)
Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort (2018) (16)
Airway inflammation despite loss of bronchial hyper-responsiveness after multiple ozone exposures. (1997) (16)
Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma (2004) (16)
Effect of a topical corticosteroid on airway hyperresponsiveness and eosinophilic inflammation induced by trimellitic anhydride exposure in sensitized guinea pigs. (1993) (16)
Modeling In Vitro Cellular Responses to Silver Nanoparticles (2014) (16)
Neutrophil influx into guinea-pig airway lumen during cholinergic and non-cholinergic bronchoconstriction. (1992) (16)
Current and future prospects for drugs to suppress cough. (2003) (16)
Blood Institute Severe Asthma Research Program (2008) (16)
Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma (2017) (16)
Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database (2004) (16)
Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough. (2015) (16)
Pharmacology of the respiratory tract : experimental and clinical research (1993) (16)
Phospho-p38 MAPK Expression in COPD Patients and Asthmatics and in Challenged Bronchial Epithelium (2015) (15)
Effect of serum on diesel exhaust particles (DEP)-induced apoptosis of airway epithelial cells in vitro. (2013) (15)
Neurogenic goblet cell secretion and bronchoconstriction in guinea pigs sensitised to trimellitic anhydride. (1995) (15)
Inhibition of cutaneous and platelet responses to platelet-activating factor by oral WEB 2086 in man. (1991) (15)
Oxidants Induce a Corticosteroid-Insensitive Phosphorylation of Histone 3 at Serine 10 in Monocytes (2015) (15)
Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma. (2019) (15)
Methods of assessing cough and antitussives in man. (1996) (15)
Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma. (1998) (15)
Road ahead to respiratory health: Experts chart future research directions (2009) (15)
PAF antagonists. Their potential therapeutic role in asthma. (1988) (15)
Increased interleukin‐10 and macrophage inflammatoryprotein‐1α release from blood monocytes ex vivo duringlate‐phase response to allergen in asthma (2000) (15)
Theophylline in chronic asthma–evidence for disease‐modifying properties (1996) (15)
Benefits of Airway Androgen Receptor Expression in Human Asthma. (2021) (14)
Type 2‐low asthma phenotypes by integration of sputum transcriptomics and serum proteomics (2020) (14)
Dealing with Stress: Defective Metabolic Adaptation in Chronic Obstructive Pulmonary Disease Pathogenesis. (2017) (14)
Variability in Bioreactivity Linked to Changes in Size and Zeta Potential of Diesel Exhaust Particles in Human Immune Cells (2014) (14)
Inhaled frusemide and asthma (1990) (14)
Inhaled frusemide and exercise-induced bronchoconstriction in children with asthma. (1995) (14)
Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 (2020) (14)
I_MDS: an inflammatory bowel disease molecular activity score to classify patients with differing disease-driving pathways and therapeutic response to anti-TNF treatment (2019) (14)
Pro-oxidant iron in exhaled breath condensate: a potential excretory mechanism. (2011) (14)
The challenge of long-acting β-adrenoceptor agonists (1991) (14)
Pharmacotherapeutic Options for Chronic Refractory Cough. (2020) (14)
Non‐invasive biomarkers of asthma (1999) (13)
Interactions of chemical components in ambient PM2.5 with influenza viruses (2022) (13)
Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma (2003) (13)
Differential effects of phosphoramidon on neurokinin A‐ and substance P‐induced airflow obstruction and airway microvascular leakage in guinea‐pig (1991) (13)
The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs. (1996) (13)
Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats. (2002) (13)
Circulating autoantibodies to recombinant lipocortin-1 in asthma. (1991) (13)
Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome. (2018) (13)
Assessing machine learning algorithms for self-management of asthma (2017) (13)
Role for platelet-activating factor in asthma (1991) (13)
Blood eosinophil count correlates with severity of respiratory failure in life‐threatening asthma and predicts risk of subsequent exacerbations (2019) (12)
Airway hyperresponsiveness to acetylcholine and to tachykinins after respiratory virus infection in the guinea pig. (1993) (12)
Bradykinin receptor subtypes in rat lung: effect of interleukin-1 beta. (1995) (12)
Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: relationship to bronchial hyperresponsiveness. (1999) (12)
Association of Differential Mast Cell Activation to Granulocytic Inflammation in Severe Asthma. (2021) (12)
Effects of nedocromil sodium on airway neurogenic mechanisms. (1996) (12)
Asthma: application of cell and molecular biology techniques to unravel causes and pathophysiological mechanisms. (2000) (12)
Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages. (2004) (12)
Effects of treatment on airway microvascular leakage. (1990) (12)
Adsorption of surfactant protein D from human respiratory secretions by carbon nanotubes and polystyrene nanoparticles depends on nanomaterial surface modification and size (2015) (12)
Effects of sodium metabisulphite on guinea pig contractile airway smooth muscle responses in vitro. (1995) (12)
Exposure to Silver Nanospheres Leads to Altered Respiratory Mechanics and Delayed Immune Response in an in Vivo Murine Model (2018) (12)
Effect of a bradykinin receptor antagonist, HOE 140, against bradykinin- and vagal stimulation-induced airway responses in the guinea-pig. (1994) (11)
Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma. (2021) (11)
Airway Smooth Muscle in Asthma and COPD (2008) (11)
Effects of a nanoceria fuel additive on the physicochemical properties of diesel exhaust particles. (2016) (11)
Prevalence of tobacco dependence and associated factors in China: Findings from nationwide China Health Literacy Survey during 2018–19 (2022) (11)
Tralokinumab unsuccessful for management of severe, uncontrolled asthma. (2018) (11)
Asthma as an inflammatory disease: clinical perspectives. (1992) (11)
Bleomycin-induced lung injury in the rat: effects of the platelet-activating factor (PAF) receptor antagonist BN 52021 and platelet depletion. (1990) (11)
Mapping atopic dermatitis and anti-IL-22 response signatures to Type 2-low severe neutrophilic asthma. (2021) (11)
Hypotonic and isotonic aerosols increase bronchial reactivity in basenji-greyhound dogs. (1987) (11)
Effect of inhaled platelet-activating factor on circulating neutrophils and platelets in vivo and ex vivo in man. (1988) (11)
TGF-regulates Nox 4 , MnSOD and catalase expression , and IL-6 release in airway smooth muscle cells (2011) (11)
eNose breathprints as a surrogate biomarker for classifying asthma patients by atopy. (2020) (11)
Patients' experiences of asthma exacerbation and management: a qualitative study of severe asthma (2021) (11)
Effect of acetazolamide and amiloride against sodium metabisulphite-induced bronchoconstriction in mild asthma. (1994) (11)
Alveolar epithelial inter-alpha-trypsin inhibitor heavy chain 4 deficiency associated with senescence-regulated apoptosis by air pollution. (2021) (11)
Decreased breath excretion of redox active iron in COPD: a protective failure? (2015) (11)
Instability of sputum molecular phenotypes in U-BIOPRED severe asthma (2020) (11)
Suppression of prolonged fever during treatment of pulmonary tuberculosis: importance of using twice versus single daily dose of prednisolone. (1983) (11)
Beta 2-adrenergic receptors on eosinophils. Binding and functional studies. (1990) (11)
Chronic inflammation in asthma (1998) (10)
Impaired innate immune gene profiling in airway smooth muscle cells from chronic cough patients (2017) (10)
Effects of prostacyclin on bronchoconstriction and neutropenia induced by inhaled platelet-activating factor in man. (1990) (10)
Exploring the clinical relevance of cough hypersensitivity syndrome (2020) (10)
Asthma : mechanisms and protocols (2000) (10)
Inhaled sodium cromoglycate in children with asthma (10)
Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline (2018) (10)
Down-regulation of insulin-like growth factor I (IGF-I) in the mouse diaphragm during sepsis. (2010) (10)
Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers (2018) (10)
Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries? (2020) (10)
Salmeterol/fluticasone combination in the treatment of COPD (2006) (10)
Cough hypersensitivity and chronic cough (2022) (10)
Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing (2017) (10)
Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study. (2019) (9)
Altered gut microbiome compositions are associated with the severity of asthma (2021) (9)
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES: Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease: Oxidative stress in asthma and COPD (2010) (9)
Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux (2019) (9)
Analysis of bronchial biopsies in chronic cough. (2017) (9)
Induction of nuclear factor-kappa B by exposure to ozone and inhibition by glucocorticoids. (2000) (9)
Factors contributing to bronchial hyper-responsiveness in asthma. (1988) (9)
Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in Brown-Norway rats (1995) (9)
Effect of frusemide on the induction and potentiation of cough induced by prostaglandin F2 alpha. (1992) (9)
Should treatments for asthma be aimed at the airway smooth muscle? (2007) (9)
Allergic airway inflammation induces migration of mast cell populations into the mouse airway (2017) (9)
Airway expression of SARS-CoV-2 receptor, ACE2, and proteases, TMPRSS2 and furin, in severe asthma (2020) (9)
Overview: why are corticosteroids ineffective in COPD? (2002) (9)
Safety and Tolerability of Indacaterol over 52 Weeks of Treatment in COPD. (2009) (9)
PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD) (2018) (9)
Treatment of asthma. (1987) (9)
Mediators of bronchial hyperresponsiveness (1990) (9)
Platelet Activating Factor Increases Vascular Permeability in Guinea Pig Airways (1986) (8)
The Clinical and Pathophysiological Challenge of Cough (2008) (8)
Chapter 27 – Cytokines (2009) (8)
Label-free TOF-SIMS imaging of sulfur producing enzymes inside microglia cells following exposure to silver nanowires. (2019) (8)
Increased Eosinophil Responsiveness to Platelet-Activating Factor in Asthma (1988) (8)
Health effects of air pollution: what we need to know and to do in the next decade. (2019) (8)
Asthma phenotypes in a multi-ethnic Asian cohort. (2019) (8)
Chronic Cough 2 Management of chronic cough (2008) (8)
Effect of sodium metabisulphite on bronchial blood flow in conscious sheep: pharmacological modulation (1994) (8)
LARYNGEAL STRIDOR DURING ACUTE ASTHMA (1982) (8)
Th2 subsetting of U-BIOPRED asthma subjects based on airway transciptomic profiles (2015) (8)
Edinburgh Research Explorer Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function (2010) (8)
Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status. (2019) (8)
Protease-activated receptor 2 in regulation of bronchomotor tone: effect of tobacco smoking. (2004) (8)
Effects of cigarette smoke on pulmonary homeostasis. (2005) (8)
Bronchial vasodilation by histamine in sheep: characterization of receptor subtype. (1992) (8)
Difficult, therapy-resistant asthma: definition and clinical features. (2000) (8)
Unmet needs in adult asthma. (2000) (8)
New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough (2019) (8)
HEALTH EFFECTS OF DIESEL EXHAUST IN ASTHMATIC PATIENTS: A REAL-WORLD STUDY IN LONDON (2005) (7)
eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy (2020) (7)
Increasing utility of FeNO as a biomarker of type-2 inflammation in severe asthma. (2021) (7)
Exercise-Induced Changes in Exhaled NO Differentiates Asthma With or Without Fixed Airway Obstruction From COPD With Dynamic Hyperinflation (2016) (7)
Long term survival after treatment of disseminated T cell lymphoma presenting with tracheal obstruction in a patient with coeliac disease. (1989) (7)
Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid (2015) (7)
Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease. (2022) (7)
Effect of theophylline on airway responses to inhaled platelet-activating factor in man. (1989) (7)
Treating acute cough: wet versus dry – have we got the paradigm wrong? (2015) (7)
Cough in hypereosinophilic syndrome: case report and literature review (2020) (7)
Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U‐BIOPRED severe asthma study (2020) (7)
Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects (2004) (7)
Imbalance of endogenous prostanoids in moderate-to-severe asthma. (2017) (7)
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of COPD (2015) (7)
Pharmacology and therapeutics of cough. Preface. (2009) (7)
Therapeutic Potential of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Recovering From Murine Pulmonary Emphysema Under Cigarette Smoke Exposure (2021) (6)
Long-COVID severe refractory cough: discussion of a case with 6-week longitudinal cough characterization (2022) (6)
Gabapentin: a suppressant for refractory chronic cough (2012) (6)
Furosemide and other diuretics in asthma. (1994) (6)
Recommendations for the use of bronchial thermoplasty in the management of severe asthma. (2015) (6)
Cytokine Regulation of Chronic Inflammation in Asthma (1995) (6)
Plasma exudation into airways induced by inhaled platelet-activating factor: effect of peptidase inhibition. (1991) (6)
Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort (2022) (6)
Asthma Treatments: Effects on the Airway Smooth Muscle (2008) (6)
Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function (2010) (6)
Platelet activating factor revisited. (1997) (6)
TRPV 1 and TRPA 1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter ( PM 2 . 5 ) (2019) (6)
IL-5 in asthma (2002) (6)
ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells. (2021) (6)
Pathophysiology and therapy of chronic cough. (2005) (6)
Th17-related cytokine expression is increased in the bronchial mucosa of stable COPD patients (2009) (6)
leukotriene B 4 from alveolar macrophages in severe asthma (2010) (6)
Respiratory viruses and asthma (2003) (6)
Theobromine for the treatment of persistent cough: a randomised, multicentre, double-blind, placebo-controlled clinical trial. (2017) (6)
PAF ANTAGONISTS IN ASTHMA (1989) (6)
Failure of sputum eosinophilia after eotaxin inhalation in asthma (2004) (6)
The challenge of long-acting beta-adrenoceptor agonists. (1991) (6)
Airway neuropeptides and neutral endopeptidase in asthma (1996) (6)
Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study (2016) (6)
Long-term inhaled corticosteroid therapy in chronic airways obstruction. (1992) (6)
Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study. (2022) (5)
Tiotropium as an add-on therapy in patients with symptomatic asthma. (2015) (5)
The anti-inflammatory effects of sulforaphane are not mediated by the Nrf2 pathway (2014) (5)
Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema. (2021) (5)
Cough: pharmacology and therapy. (2002) (5)
Effect ofβ(in2)-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig (1993) (5)
Airway smooth muscle cells from patients with COPD exhibit a higher degree of cellular proliferation and steroid insensitivity than that from healthy patients (2011) (5)
Questions about inhaled beta 2-adrenoceptor agonists in asthma. (1992) (5)
Signalling and transcriptional regulation in inflammatory and immune cells: importance in lung biology and disease (2005) (5)
Influence of Comorbidities and Airway Clearance on Mortality and Outcomes of Patients With Severe Bronchiectasis Exacerbations in Taiwan (2022) (5)
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation (2021) (5)
Attenuation of platelet-activating factor induced bronchoconstriction by nedocromil sodium. (1992) (5)
Predictive Model Of Severe Atopic Asthma Phenotypes Using Interleukin 4/13 Pathway Polymorphisms (2011) (5)
A Topological Data Analysis Network Model of Asthma Based on Blood Gene Expression Profiles (2019) (5)
Interaction of ozone exposure with airway hyperresponsiveness and inflammation induced by trimellitic anhydride in sensitized guinea pigs. (1997) (5)
Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in the guinea pig. (1993) (5)
Management of difficult asthma. (1994) (5)
Advancing the Understanding of Environmental Transformations, Bioavailability and Effects of Nanomaterials, an International US Environmental Protection Agency—UK Environmental Nanoscience Initiative Joint Program (2018) (5)
ect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects (1998) (5)
Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study (2021) (5)
Indacaterol: pharmacologic profile, efficacy and safety in the treatment of adults with COPD (2011) (5)
Staphylococcal enterotoxin‐specific IgE: a biomarker for a distinct phenotype of severe asthma? (2016) (5)
Intrinsic differences of the airway epithelium in childhood allergic asthma. (2006) (5)
Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD (2014) (5)
Dose-dependent inhibition of allergic inflammation and bronchial hyperresponsiveness by budesonide in ovalbumin-sensitised Brown-Norway rats. (2008) (5)
Breathing pattern changes in refractory chronic cough with physiotherapy speech and language therapy intervention (2016) (5)
Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study. (2022) (5)
Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings. (1989) (5)
Retrospective comparison of high-resolution computed tomography of eosinophilic granulomatosis with polyangiitis with severe asthma (2021) (4)
Breathomics can discriminate between anti IgE-treated and non-treated severe asthma adults (2015) (4)
Progress at the interface of inflammation and asthma: Report of the ALA/ATS workshop on future directions in asthma research (1995) (4)
Measurement and Assessment of Cough (2008) (4)
Endotoxin-induced plasma exudation in guinea-pig airways in vivo and the effect of neutrophil depletion. (1990) (4)
“International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.” Kian Fan Chung, Sally E. Wenzel, Jan L. Brozek, et al. Eur Respir J 2014; 43: 343–373. (2022) (4)
Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (2017) (4)
Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort. (2021) (4)
Effects of antibiotics and metals on lung and intestinal microbiome dysbiosis after sub-chronic lower-level exposure of air pollution in ageing rats. (2022) (4)
The complementary role of ducocorticosteroids and long (1998) (4)
2-year safety and efficacy results for benralizumab. (2019) (4)
ResearchPharmacological studies of the mechanism and function of interleukin-1 β-induced miRNA-146 a expression in primary human airway smooth muscle (2010) (4)
Cough as a symptom. (2004) (4)
The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults (2022) (4)
TLR3/TAK1 signalling regulates rhinovirus-induced interleukin-33 in bronchial smooth muscle cells (2020) (4)
Unbiased clustering of children with asthma or pre-school wheeze using the U-BIOPRED electronic nose platform (2014) (4)
Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort (2022) (4)
Editorial: Ozone as a Driver of Lung Inflammation and Innate Immunity and as a Model for Lung Disease (2021) (4)
Clinicians' Guide to Asthma (2002) (4)
Exhaled breath condensate in chronic cough. (2005) (4)
Neutrophils and Their Mediators in Asthma and Allergic Disease (2009) (4)
Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma (2017) (4)
Histamine release and circulating cells after antigen inhalation in allergic dogs (1987) (4)
Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat. (1994) (4)
Identifying and appraising outcome measures for severe asthma: a systematic review (2022) (4)
The first U-BIOPRED blood handprint of severe asthma (2015) (4)
Lung toxicity of particulate and gaseous pollutants using ex-vivo airway epithelial cell culture systems. (2022) (4)
Zafirlukast (Accolate(TM)) (1998) (4)
Mechanisms of Impaired b-Adrenoceptor-induced Airway Relaxation by Interleukin-1 b In Vivo in the Rat (2013) (4)
Corticosteroids: use and insensitivity in severe asthma (2011) (4)
Mitochondrial reactive oxygen species and glycolysis in airway smooth muscle cell proliferation in COPD (2015) (3)
Characteristics of asthma in U-BIOPRED severe and non-severe cohorts with distinct biomarker profiles (2015) (3)
The current debate concerning beta-agonists in asthma: a review. (1993) (3)
John Widdicombe’s contribution to respiratory physiology and cough: reminiscences (2013) (3)
The role of new asthma treatments (1998) (3)
Opioid modulation ofnon-cholinergic neural bronchoconstriction inguinea-pig invivo (1988) (3)
Whole-genome sequencing in critically ill infants and emerging ethical challenges (2015) (3)
Overcoming Steroid Insensitivity in Respiratory Disease (2008) (3)
COUGH: consolidating a mature field for the next 5 years (2011) (3)
New treatments for severe asthma (2011) (3)
Characteristics, phenotypes, mechanisms and management of severe asthma (2022) (3)
An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype (2021) (3)
Intracellular interactions of umeclidinium and vilanterol in human airway smooth muscle (2017) (3)
Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs (1993) (3)
Shedding light on corticosteroid-resistant type 2-high severe asthma. (2019) (3)
Inhaled corticosteroid dose-reducing effect of omalizumab in patients with controlled, severe asthma according to usage of inhaled long-acting beta-agonists (2002) (3)
Chronic cough in asthma is associated with increased airway inflammation, more comorbidities, and worse clinical outcomes. (2022) (3)
Dedicated severe asthma services improve healthcare utilisation and quality of life (2013) (3)
Maintenance Negative Pressure Ventilation Improves Survival in COPD Patients with Exercise Desaturation (2019) (3)
AsthmaMap: an interactive knowledge repository for mechanisms of asthma. (2020) (3)
Acute and chronic cough. (2004) (3)
Erratum: International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma (European Respiratory Journal (2014) 43 (343–373) DOI: 10.1183/09031936.00202013) (2018) (3)
Tobacco industry lobbyists and their health-care clients (2013) (3)
Effects of Pharmacologic Antagonist Activity and Bronchodilatation on the Bronchial Dose-Response Curve to Methacholine (1983) (3)
Omalizumab improves symptom control in patients with porly controlled allergic asthma and concomitant rhinitis (2003) (3)
Characteristics of the frequent exacerbator in U-BIOPRED adult severe asthma cohort (2015) (3)
2. Joint statement -- AAAAI/ACAAI Joint Statement of Support of the ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide for Clinical Applications 3. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. (2014) (3)
Inhaled silver nanoparticles induce pulmonary oxidative injury and inflammation: Differential effects between rat strains (2014) (3)
International research collaboration: The way forward (2018) (3)
The eosinophil in airway inflammation: potential role and pharmacologic modulation (1993) (3)
Anti-IgE therapy of asthma. (2002) (3)
Association of air pollution exposure with exercise-induced oxygen desaturation in COPD (2022) (3)
eTRIKS IT platfroms for large-scale biomedical research (2015) (3)
Sex Hormones and Asthma (1999) (3)
Other Mediators of Asthma (1998) (3)
Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma. (2017) (3)
Clustering analysis of clinical variables in U-BIOPRED adult asthma cohort (2014) (3)
Alveolar m macrophage-induced s suppression o of p peripheral blood m mononuclear c cell rresponsiveness iis rreversed b by in v vitro allergen e exposure iin b bronchial a asthma (1994) (3)
Accounting for measurement error to assess the effect of air pollution on omic signals (2018) (3)
Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort (2018) (3)
Haze, health and disease. (2015) (3)
Lipoxins and epoxyeicosatrienoic acids. Potential for inhibitors of soluble epoxide hydrolase in severe asthma? (2014) (3)
myAirCoach: mHealth assisted self-management in patients with uncontrolled asthma, a randomized control trial (2019) (3)
Increased Interleukin-17 and Glucocorticoid Receptor-β Expression in Interstitial Lung Diseases and Corticosteroid Insensitivity (2022) (3)
Analysis of the Sputum Microbiome in the Severe Asthma (2016) (3)
Retraction notice to kinase inhibitors and airway inflammation [Eur. J. Pharmacol 533/1-3 (2006) 118 – 132 of kinase inhibitors and airway inflammation]. (2012) (3)
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The Effect of Aging and Menopause on Asthma Severity in Women (2014) (3)
IL1RAP expression and the enrichment of IL‐33 activation signatures in severe neutrophilic asthma (2022) (3)
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Pharmacology of airway inflammation in asthma (2007) (3)
Increased Th1 Cells with Disease Resolution of Active Pulmonary Tuberculosis in Non-Atopic Patients (2021) (3)
Genome-Wide Association Study of Korean Asthmatics: A Comparison With UK Asthmatics (2020) (2)
Inhibition of the cutaneous response to antigen by a thromboxane-synthetase inhibitor (OKY-046) in allergic dogs. (1989) (2)
More Data on Risks and Outcomes of COVID-19 in Asthma, COPD, and Bronchiectasis (2021) (2)
Chronicity and progression of asthma (1998) (2)
Volatile Organic Compounds Breathprinting of U-BIOPRED Severe Asthma smokers/ex-smokers cohort (2017) (2)
Effects of Pharmacological Antagonists on the Slope and Position of Histamine Dose-Response Curves: Importance of Initial Bronchial Calibre (1981) (2)
Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA (2016) (2)
18 – Biology of Monocytes and Macrophages (2014) (2)
REVIEW ARTICLE Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease (2015) (2)
Allergen Responses Modified by a GATA3 DNAzyme. (2015) (2)
Effect of silver nanospheres and nanowires on human airway smooth muscle cells: role of sulfidation (2020) (2)
Recommendations for the design of clinical trials and the registration of drugs used in the treatment of asthma (2012) (2)
Prostaglandin F2 alpha increases responsiveness of pulmonary airways in dogs. (1984) (2)
The Effect upon Specific Airway Conductance and Bronchial Reactivity of Bronchodilatation with Salbutamol (1983) (2)
Systemic corticosteroid-associated serum analyte profiles in the U-BIOPRED severe asthma cohort (2015) (2)
LATE-BREAKING ABSTRACT: Transcriptomic fingerprinting in severe adult-onset asthma shows type2-high and inflammatory-cell gene signatures in the U-BIOPRED cohort (2015) (2)
Trends in prevalence, mortality, and disability-adjusted life-years relating to chronic obstructive pulmonary disease in Europe: an observational study of the global burden of disease database, 2001–2019 (2022) (2)
Modulation of neurally mediated airway microvascular leakage in guinea-pig airways byβ2 agonists (1992) (2)
MMP10andMETas predictive classifiers of bronchial eosinophilic asthma in UBIOPRED (2015) (2)
Is Fezakinumab, an anti-IL22 antibody, a putative novel therapy for a subset of severe asthma? (2019) (2)
Lack of a role for bradykinin in allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig (1996) (2)
TGF- b Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD (2018) (2)
Reversal of Relative Corticosteroid Insensitivity in PBMCs from Patients with COPD by p38 MAPK Inhibition. (2009) (2)
The 2008 Fifth International Cough Symposium: mechanisms and treatment. (2009) (2)
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough (2022) (2)
IL-33 has a nuclear distribution and is not increased in peripheral lung of COPD patients (2011) (2)
Serum Hepcidin Levels Are Elevated In COPD And Are Associated With Increased Intracellular Iron In The Lung (2012) (2)
The Eighth 2014 International London Cough Symposium. (2015) (2)
Functional Characteristics of Beta-Adrenergic Receptors of the Intact Eosinophil (1989) (2)
Urinary Amino-Polycyclic Aromatic Hydrocarbons in Urban Residents: Finding a Biomarker for Residential Exposure to Diesel Traffic. (2021) (2)
Severe eosinophilic asthma in Chinese C‐BIOPRED asthma cohort (2022) (2)
Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA) (2022) (2)
Prevalence and burden of chronic cough in China: a national cross-sectional study (2022) (2)
Ozone-Induced Bronchial Hyperreactivity and Airway Inflammation in the Rat (1986) (2)
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Airway obstruction in chronic obstructive pulmonary disease. (2004) (2)
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Modules, networks and systems medicine for understanding disease and aiding diagnosis (2014) (2)
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Higher alveolar deposition of particulate matter in emphysematous lobes of COPD (2021) (2)
Methotrexate: does it treat or induce asthma? (1992) (2)
EditorialCough: acute and chronic (2004) (2)
About the Authors (2011) (2)
miRNA-145 & SMAD3 expression in patients with COPD (2014) (2)
Association Between Air Pollution and Lung Lobar Emphysema in COPD (2021) (2)
T cell receptor repertoire in peripheral blood and bronchial biopsies from normal and asthmatic subjects. (1996) (2)
The Seventh International Symposium on Cough: hypertussivity and allotussivity. (2013) (2)
Molecular evidence of Group 1 innate lymphoid cell activation in the U-BIOPRED cohort (2017) (2)
Novel Type 2-high gene clusters associated with corticosteroid sensitivity in COPD (2020) (2)
Rare Beta2-Adrenergic Receptor Gene Polymorphisms In Asthma Cases And Controls From The Severe Asthma Research Program (2011) (2)
Discovery and Validation of New Biomarkers for Personalizing Asthma Therapy (2018) (2)
Discrimination between oral corticosteroid-treated and oral corticosteroid-non-treated severe asthma patients by an electronic nose platform (2014) (2)
Effect of a PAF Antagonist, BN52063 on Antigen-Induced Cutaneous Responses in Atopic Subjects (1988) (2)
Unbiased clustering of severe asthma patients based on exhaled breath profiles (2015) (2)
Exhaled breath VOCs are associated with nocturnal wakening in asthmatic children (2015) (2)
U-BIOPRED accessible handprint: combining omics platforms to identify stable asthma subphenotypes (2018) (2)
Effect of A Platelet Activating Factor (PAF) Antagonist (Web 2086) on Paf Induced Airway Microvascular Leakage and Platelet Aggregation (1987) (2)
Histamine release and circulating cells after antigen inhalation in allergic dogs. (1987) (2)
Mitochondrial Dysfunction as a Therapeutic Target in COPD (2017) (2)
Late Breaking Abstract - Comparison of the blood transcriptomic profiles of adults and children from the U-BIOPRED asthma study (2017) (2)
A Genome Wide Association Study of Moderate-Severe Asthma in subjects from the United Kingdom (2017) (2)
LSC Abstract – The AsthmaMap: Towards a community-driven reconstruction of asthma-relevant pathways and networks (2016) (2)
Chronic mucosal inflammation (1998) (2)
Age And Sex Distribution Of Patients Presenting To Specialist Cough Clinics (2013) (2)
Role of TRPA1/TRPV1 in acute ozone exposure induced murine model of airway inflammation and bronchial hyperresponsiveness (2022) (2)
Predicting Response to Triamcinolone in Severe Asthma by Machine Learning. Solving the Enigma (2019) (2)
Mitochondrial Transfer Regulates Bioenergetics in Healthy and COPD Airway Smooth Muscle. (2022) (2)
Impact of Annual Exposure to Polycyclic Aromatic Hydrocarbons on Acute Exacerbation Frequency in Asthmatic Patients (2021) (2)
Cytokine mRNA profiles of normal and asthmatic peripheral blood cells and endobronchial biopsies. (1996) (2)
YAP-regulated type II alveolar epithelial cell differentiation mediated by human umbilical cord-derived mesenchymal stem cells in acute respiratory distress syndrome. (2023) (1)
Oxygen desaturation is associated with fibrocyte activation via epidermal growth factor receptor/hypoxia-inducible factor(HIF)-1a axis in COPD (2019) (1)
Sputum Metagenomic Profiling Identifies Altered Airway Microbiome in Severe Asthma Linked to Neutrophilic Airways (2019) (1)
Unsupervised and externally validated clinical cluster analysis from the U-BIOPRED paediatric cohorts (2018) (1)
Non‐asthmatic eosinophilic bronchitis is characterized by proximal airway eosinophilic inflammation as compared with classic asthma and cough variant asthma (2021) (1)
Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD (2022) (1)
Asthma. European Respiratory Monograph (2003) (1)
Corticosteroid responsiveness and resistance in severe asthma (2019) (1)
Histone demethylation and acetylation are involved in the epigenetic regulation of epithelial-mesenchymal transition (EMT) (2013) (1)
Safety of bronchial thermplasty in patients with severe refractory asthma. (2013) (1)
Severe asthma: the way forward (2011) (1)
Chapter 52 – Mediator Antagonists (2009) (1)
Mitochondrial reactive oxygen species (ROS) mediate proliferation and cytokine release in airway smooth muscle cells of patients with COPD (2014) (1)
Mitochondrial-Related Gene Expression and Macrophage Signatures in Non-Small Cell Lung Cancer, Including Patients with Emphysema as Co-Morbidity (2017) (1)
Abstracts from the 3rd International Severe Asthma Forum (ISAF) (2017) (1)
Tackling the Neuropathic Cough of Idiopathic Pulmonary Fibrosis (IPF): More Needs to be Done (2022) (1)
Late Breaking Abstract - Cluster analysis of treatable traits in the U-BIOPRED adult severe asthma cohort (2017) (1)
Difficult asthma: Authors' reply (1989) (1)
Effect of frusemide on the induction and potentiation of cough induced by prostaglandin F2o, (2006) (1)
Effects of hydrogen sulfide on ozone-induced features of chronic obstructive pulmonary disease (2015) (1)
Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts (2022) (1)
The role of glycolysis in TGF-β-mediated airway smooth muscle cell proliferation (2014) (1)
Proteome fingerprints define groups with distinct clinico-pathological phenotypes in the U-BIOPRED asthma study (2016) (1)
Erratum to “Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness” [Eur. J. Pharmacol. 452 (2002) 123–133] (2002) (1)
Clinical and transcriptomic profiles of severe asthmatics with high or low expression of the glucocorticoid receptor and importin-7. (2018) (1)
Late Breaking Abstract - Comparison of clinical characteristics between severe adult asthmatics in Brazil(ProAR) and Europe(U-BIOPRED) (2017) (1)
A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD (2022) (1)
Chapter 21. Management of difficult-to-treat severe asthma (2011) (1)
Clinical and histological comparison of smoking and non-smoking patients with severe asthma in the U-BIOPRED cohort (2014) (1)
A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes (2021) (1)
Differential Effect of Inflammatory Mediators on Microvascular Permeability in Different Parts of the Guinea Pig Airways (1988) (1)
Cough hypersentivity syndrome: Preliminary findings of the ERS taskforce (2013) (1)
Chapter 28 – Cytokines (2002) (1)
Current and potential improvements in the treatment of asthma from increased understanding of airway pathophysiology (2002) (1)
Impact of air pollutant of polycyclic aromatic hydrocarbons (PAHs) on the yearly decline of pulmonary in patients with asthma (2020) (1)
IFN-γ: A Driver of Cough Hypersensitivity Pathways in Chronic Cough? (2018) (1)
The long intergenic non-coding RNA, PVT1, regulates the TGF-β-induced proliferative response in airway smooth muscle cells from severe asthmatics (2013) (1)
3TR: a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD (2021) (1)
H+/K+‐ATPase (proton pump) inhibitors dampen increased cough reflex: more than gastric acid suppression (2005) (1)
Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1α Axis in Chronic Obstructive Pulmonary Disease (2022) (1)
Green respiratory health care: Time for us all to act (2018) (1)
Corrigendum to “Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation” [European Journal of Pharmacology 600 (2008) 117-122] (2009) (1)
The lung microbiome in obstructive airways disease: potential pathogenetic roles (2019) (1)
A silent revolution: phenotyping asthma for personalised medicine. (2015) (1)
Influence of Airway Calibre on Aerosol Deposition in Normal and Asthmatic Airways: Relationship to Airway Reactivity (1983) (1)
Gene signatures from U-BIOPRED transcriptomic-associated clusters exist in COPD (2017) (1)
Sputum gene signature comparison study between U-BIOPRED and Australia asthma cohorts (2019) (1)
New Drugs: Respiratory and allergic disease. II. Chronic obstructive airways disease and respiratory infections (1988) (1)
Patients' perspective of physiotherapy, speech and language therapy intervention (PSALTI) for refractory chronic cough:Secondary analysis (2016) (1)
Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA (2018) (1)
Immunologic Challenge and Epithelial Ion Transport in Canine Trachea (1985) (1)
Association of endopeptidases, involved in SARS‐CoV‐2 infection, with microbial aggravation in sputum of severe asthma (2021) (1)
Mechanisms of action of corticosteroids in asthma (1998) (1)
Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema (2021) (1)
Active Control of Functional Residual Capacity in Anaesthetised Dogs (1982) (1)
A hypothesis driven approach investigating the interleukin-6 pathway in UBIOPRED severe asthma patients (2017) (1)
[Severe asthma: can we do better?]. (2003) (1)
Cultured human airway epithelial cells release fibroblast mitogens: a role for insulin-like growth factor 1 (IGF-1) (1993) (1)
LIPID MEDIATORS | Platelet-Activating Factors (2006) (1)
The experience of tobacco withdrawal symptoms among current smokers and ex-smokers in the general population: Findings from nationwide China Health Literacy Survey during 2018-19 (2023) (1)
Emphysema-Predominant COPD Had a Greater 5-Year Mortality and a Worse Annual Decline in Lung Function Than Airway Obstruction-Predominant COPD or Asthma at Initial Same Degree of Airflow Obstruction (2021) (1)
Physician-prescribed Asthma Treatment Regimen does not differ Between Smoking and Non-smoking Patients With Asthma in Seoul and Gyunggi province of Korea (2014) (1)
Metabolic re-patterning in chronic obstructive pulmonary disease airway smooth muscle cells (2017) (1)
Interstitial lung abnormalities: What do we know and how do we manage? (2021) (1)
Mechanisms of bronchial inflammation in asthma: implications for therapy. (1992) (1)
Triggers and type of asthma in patients with at risk severe asthma: Data from the PARA UK database (2001) (1)
The Airway Smooth Muscle in Chronic Obstructive Pulmonary Disease (COPD) (2008) (1)
Altered airway microbiome in stable asthma (2012) (1)
Fluticasone furoate and vilanterol for the treatment of chronic obstructive pulmonary disease (2017) (1)
The Sixth 2010 London International Symposium on Cough: A translational approach. (2011) (1)
Spirometric phenotypes from early childhood to young adulthood – A CADSET (Chronic Airway Disease Early Stratification) study (2020) (1)
Computational modeling methods for simulating obstructive human lung diseases (2016) (1)
MA12.04 Mitochondrial-Related Proteins, PGAM5 and FUNDC1, in COPD-Associated Non-Small Cell Lung Carcinoma (2017) (1)
Weighted Gene Co-expression Network Analysis of blood paediatric samples from the U-BIOPRED study identifies oxidative stress association with asthma severity (2018) (1)
Whole transcriptome analysis in peripheral blood from asthmatic and healthy subjects in the U-BIOPRED study (2014) (1)
The anti-proliferative effect of hydrogen sulfide upon human airway smooth muscle in COPD (2014) (1)
Corticosteroid insensitivity in severe asthma: impaired nuclear translocation of glucocorticoid receptor in airway smooth muscle cells (2012) (1)
Associated factors with persistent airflow limitation in asthma in U-BIOPRED (2013) (1)
function of interleukin-1β-induced miRNA-146a expression in primary human airway smooth muscle (2010) (1)
STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects (2012) (1)
β2‐adrenergic agonists, corticosteroids and IgE production (1995) (1)
mHealth systems for asthma self-management: Opinions of people with asthma and healthcare professionals (HCPs) on their use and functions (2016) (1)
Active Air Monitoring for Understanding the Ventilation and Infection Risks of SARS-CoV-2 Transmission in Public Indoor Spaces (2022) (1)
Predictive performance of non-invasive Type 2 biomarkers for asthmatic sputum eosinophilia in Bobcat and U-Biopred studies (2016) (1)
Label-Free Time-of-Flight Secondary Ion Mass Spectrometry Imaging of Sulfur-Producing Enzymes inside Microglia Cells following Exposure to Silver Nanowires (2019) (1)
Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China (2022) (1)
Associations between lung-deposited dose of particulate matter and culture-positive pulmonary tuberculosis pleurisy (2021) (1)
Importance of surface charge of soot nanoparticles in determining inhalation toxicity in mice (2022) (1)
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Airway Smooth Muscle Dysfunction in Asthma (2009) (0)
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with bronchodilation air trapping and incomplete reversal of obstruction Lung function in adults with stable but severe asthma (2015) (0)
Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers (2018) (0)
Patterns and Characteristics of Tobacco Withdrawal Symptoms Among Chinese Smokers (2022) (0)
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Airway remodelling in the U-BIOPRED severe asthma cohort (2015) (0)
Sputum transcriptomics identifies co-expressed network signatures associated with Fev1 and sputum neutrophilia in severe asthmatics on oral corticosteroids (2016) (0)
Matrix metalloproteinases in airways inflammation of asthma and chronic obstructive pulmonary disease (2008) (0)
Corticosteroid Responsiveness in Asthma: Clinical Aspects (2008) (0)
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A CADSET WP4 transcriptomic analysis of Asthma and COPD overlap (2020) (0)
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Key Insights from the ATS/ERS 2014 Guidelines on Severe Asthma (2014) (0)
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Smoking and treatments among asthma patients in South Korea (2011) (0)
Detection of a Persistent Rv16 Infection Signature in Stable Neutrophilic Moderate to Severe Asthmatic Patients in the U-BIOPRED Cohort (2019) (0)
IL-4 and IL-13 Form a Negative Feedback Circuit with Surfactant Protein-D in the Allergic Airway Response 1 (2006) (0)
Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD (2023) (0)
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Genomic and ecologic characteristics of the airway microbial-mucosal complex (2022) (0)
Androgen Metabolism and Severe Asthma: HSD3B1 Genotype Identifies Glucocorticoid Responsiveness (2020) (0)
First Rounders Podcast: James Wilson (2016) (0)
Severe asthma management in adults (2019) (0)
Platelet-Activating Factor (2021) (0)
Unmet clinical needs in asthma: Childhood to old age (1998) (0)
Corticosteroid insensitivity in airway smooth muscle cells of severe asthma and COPD: Modulation by IFN-γ (2012) (0)
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Recent Thymic Emigrants Do Not Account for the Increased Number of TCells Seen in the Lungs of Stable Chronic Obstructive Pulmonary Disease (2008) (0)
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Definitions of non-response and response to biological therapy for severe asthma: a systematic review (2023) (0)
PAF Antagonists (1988) (0)
Uncommon causes of chronic cough associated with airway eosinophilia (2021) (0)
Cytokines: An Overview (2001) (0)
ADEPT-derived, U-BIOPRED validated asthma clinical clusters with Th2 and non-Th2 phenotypes (2014) (0)
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New asthma treatments: recent advances and current objectives (1998) (0)
Metagenomic Analysis of Sputum in the U-Biopred Cohort Shows Reduced Diversity in Asthmatics (2019) (0)
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The history of drug development and asthma management (1998) (0)
Pharmacological and therapeutic aspects of airway narrowing and hyperresponsiveness in asthma (1993) (0)
Endogenous hydrogen sulfide (H2S) in serum and sputum as novel biomarker of asthma (2012) (0)
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Prevalence and Risk Factors of Alcohol Dependence, and Association with Smoking in China: Findings from a National Cross-Sectional Study (2022) (0)
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Cough Hypersensitivity Syndrome – A Major Advance in the Understanding of Chronic Cough (2018) (0)
The effect of JQ1/SGCBD01 upon c-Myc in human airway smooth muscle in asthma (2014) (0)
Increased METEORIN-LIKE (ML) expression promotes lung inflammation in asthma (2019) (0)
Novel Anti‐Inflammatory Treatments for Asthma and COPD (2012) (0)
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Characterisation of a novel 3D model of the airways (2015) (0)
Early radiologic and bronchoscopic changes after bronchial thermoplasty in patients with severe asthma (2020) (0)
Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/ Hypoxia-Inducible Factor-1α Axis in Chronic Obstructive Pulmonary Disease (2021) (0)
Using Single Cell Sequencing to Understand Treatment Response to Anti-IL33 Treatment in Chronic Obstructive Pulmonary Disease (COPD) (2023) (0)
Gene set variation analysis of mRNA expression in bronchial biopsies from the U-BIOPRED asthma study (2014) (0)
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afferent neurons in the antitussive effects of menthol The role of trigeminal nasal TRPM8-expressing (2015) (0)
Nanoparticles disrupt lung function either directly or by inflammatory induction (2012) (0)
Relationship between mitochondrial function and cellular ageing depends upon compartment analysed (2016) (0)
Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers (2018) (0)
Phenotyping Nasal Epithelial Cells in Severe Eosinophilic Asthma Patients (2023) (0)
The carnitine pathway is dysregulated in asthma in an oral corticosteroid-independent mechanism (2021) (0)
A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model (2022) (0)
Prediction of longitudinal inflammatory phenotypes using baseline sputum transcriptomics in UBIOPRED (2019) (0)
Sensory neurophysiology of the cough reflex. Discussion (1996) (0)
TNFAIP3 (A20) expression is elevated in the sputum of severe asthmatics (2016) (0)
Further resolution of non-T2 asthma subtypes from high-throughput sputum transciptomics data in U-BIOPRED (2018) (0)
Mechanisms of nasal epithelial cell permeability in eosinophilic Severe Asthma: effect of anti-IL5R therapy (2022) (0)
The U-BIOPRED severe asthma study: Immunopathological characterisation (2014) (0)
Urinary LTE4 may be associated with TH2-driven asthma: Initial data from the Pan-European U-BIOPRED IMI project (2014) (0)
Domiciliary diurnal variation of fractional exhaled nitric oxide (FeNO) to monitor asthma control (2013) (0)
Mandarin Translations (2012) (0)
Combined analysis of gene expression and clinical data in the severe asthma U-BIOPRED cohorts (2014) (0)
Urinary metabolomics-profiling of the U-BIOPRED asthma study identified biochemical clusters associated with asthma severity (2020) (0)
Identifying Gene Regulatory Networks of TREM-1 Response in Asthma (2019) (0)
Characteristics of the adult corticosteroid-dependent severe asthma in UBIOPRED consortium (2014) (0)
Diesel exhaust particles inhibit lung branching morphogenesis via the YAP/TAZ pathway. (2022) (0)
Acknowledgement to reviewers 2009 (2010) (0)
Platelet—Activating Factor in Endotoxin and Immune Diseases (1991) (0)
Mast cell gene signature enrichment associates with late-onset severe asthma (2016) (0)
Indications for the use of bronchial thermoplasty in severe asthma. (2015) (0)
Predictors of Asthma Exacerbations in Th2 High vs. Th2 Low Patients (2019) (0)
Understanding Life: Focus on Physiology (2018) (0)
MIF antagonism restores corticosteroid sensitivity in a murine model of severe asthma (2018) (0)
Effects of theophylline on airway eosinophils. Authors' reply (2002) (0)
Effect of TGF-β on FoxO activity in airway smooth muscle cells (2012) (0)
ParkinMediatesNonclassical,Proteasomal-Independent UbiquitinationofSynphilin-1:ImplicationsforLewy BodyFormation (2009) (0)
“Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD”. Ariel A. Calderon, Colin Dimond, David F. Choy, Rajita Pappu, Michele A. Grimbaldeston, Divya Mohan and Kian Fan Chung. Eur Respir Rev 2023; 32: 220144 (2023) (0)
miR-146a Regulates the IL-1β-Induced Inflammatory Response in Primary Human Airway Smooth Muscle Cells. (2009) (0)
Clinical Assessment and Utility of Biomarkers in Asthma-Chronic Obstructive Pulmonary Disease Overlap. (2022) (0)
Altered mitochondrial function in proliferating airway smooth muscle cells (2019) (0)
255 Microarray Analysis Maps Global Effects of Epigenetic Bromodomain Inhibitor JQ1 on Gene Expression in Transforming Growth Factor-β-Stimulated Adult Lung Fibroblasts (2016) (0)
Effects of N-acetylcysteine on airway inflammation, airway hyperresponsiveness and abnormal lung function in chronic ozone-induced COPD model (2012) (0)
Physiology of severe vs. mild-moderate U-BIOPRED cohorts interpreted using a computational model (2015) (0)
Enrichment of the Janus kinase (JAK) activation signature in severe asthma sputum: Correlation with IL-13 expression (2016) (0)
Differential mast cell activation by transcriptomic signature analysis in the U-BIOPRED severe asthma cohort (2020) (0)
Asthma, COPD & ACOS: -Omics Approach to Refine Treatable Traits in These Conditions (2017) (0)
Neutrophilic inflammation in sputum does not define a clinical distinct asthma phenotype in ATLANTIS (2021) (0)
Gastroesophageal Reflux Predicts Asthma Exacerbations in Obese Asthmatics (2019) (0)
Phosphoinositide-3-kinase gamma/delta isoform signalling defines a mixed T cell severe asthmatic endotype (2017) (0)
Differential Expression Of MicroRNAs In Asthmatic Airway Smooth Muscle (2012) (0)
T17 gene asthma signature characterized by sputum neutrophilia and regular use of antibiotics (2017) (0)
Rhinovirus-induced IL-33 is overexpressed in asthmatic bronchial smooth muscle cells via TLR3 and activation of TAK1 (2019) (0)
High-fat diet in mice leads to amplified ozone-induced airway hyperresponsiveness (AHR), mitochondrial dysfunction and insulin resistance (2016) (0)
European Trends in Chronic Obstructive Pulmonary Disease Mortality and Incidence rates 2001 to 2017 (2020) (0)
Measuring exhaled hydrogen sulphide (eH2S) levels in asthma (2016) (0)
Determinants of inflammatory and functional toxicity of silver nanospheres in rat lung (2013) (0)
Correction to: Research Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function (2021) (0)
Regulation of Oxidant and Antioxidant Enzyme Expression by TGF-β in Human Airway Smooth Muscle Cells. (2009) (0)
Central role for phosphoinositide-3-kinase gamma/delta dependent signalling in eosinophilic pulmonary inflammation driven by innate lymphoid cells (2017) (0)
Asthma severity and improvements in asthma status following bronchial thermoplasty (BT). (2008) (0)
Severe asthma: characterisation, mechanisms & treatment (2012) (0)
Urinary metabolomics-based molecular sub-phenotyping of the U-BIOPRED asthma cohort (2017) (0)
Respirology year‐in‐review 2006: Basic science (2007) (0)
Inhaled frusemide and asthma (1990) (0)
Serum pregnancy-associated plasma protein A (PAPPA) as a predictor of eosinophilic Type-2 high asthma (2021) (0)
Late Breaking Abstract - Longitudinal analysis of variation in clinical features from the U-BIOPRED severe asthma cohort (2018) (0)
Hydrogen sulfide (H2S) in sputum and serum as a novel biomarker of COPD (2014) (0)
Multivariate cluster analysis of immunopathological and clinical data from the U-BIOPRED severe asthma study: Preliminary results (2015) (0)
Chapter 13. Cough in Chronic Obstructive Pulmonary Disease (2008) (0)
Mechanisms of Mitochondrial Transfer in Health and Disease (2019) (0)
Cough Focused Series: progress in understanding and management of chronic cough (2022) (0)
Physiotherapy for breathing pattern dysfunction in chronic refractory cough – Don't hold your breath (2014) (0)
Comprar Pharmacology and Therapeutics of Cough | Chung, Kian Fan | 9783540798415 | Springer (2009) (0)
Retraction Note: The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide (2021) (0)
Comprar Psychiatry, 2 Volume Set | Prof. Kian Fan Chung | 9780470065716 | Wiley (2008) (0)
464 CD4+ but not CD8+ T cells transfer allergic airway hyperresponsiveness (AHR) in BN-rats (1996) (0)
SARS-CoV2 and Air Pollution Interactions: Airborne Transmission and COVID-19 (2022) (0)
vin-induced plasma exudation in guinea-pig airways in vivo and the effect of neutrophil depletion (2012) (0)
Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study (2016) (0)
Asthma and Wheeze Severity and the Oropharyngeal Microbiota in Children and Adolescents. (2022) (0)
- 1-Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells (2009) (0)
Regulation of mitochondrial transfer between airway smooth muscle cells: relevance to COPD (2019) (0)
Distinct pathways underlying neutrophilic inflammation in smoking-associated severe asthma in U-BIOPRED (2017) (0)
How does obesity correlate with severe asthma (2011) (0)
The complexity of the asthma phenotype (1998) (0)
Radiomics for severe asthma phenotyping and endotyping (2022) (0)
Go-ahead for human genome editing with caveats (2016) (0)
TGF-β1-Mediated CTGF Upregulation Through Transactivation of EGFR in Fibrocytes of Chronic Obstructive Asthma (2017) (0)
emphysema after multiple ozone exposures in mice A model of chronic inflammation and pulmonary (2016) (0)
Thrombospondin-1 and vascular endothelial growth factor expression and their relationship with microvessel density in hepatocellular carcinoma (2002) (0)
Staphylococcus aureus Enterotoxin-Specific IgE Sensitization in Severe Eosinophilic Asthma Phenotype (2023) (0)
Integrated analysis reveals lung fibrinogen gamma chain as a biomarker for chronic obstructive pulmonary disease (2021) (0)
Is exposure to pollen a risk factor for moderate and severe asthma exacerbations? (2023) (0)
Five-Year Mortality of Chronic Obstructive Pulmonary Disease (COPD) Patients Is Greater than That of Asthmatics at Similar Airflow Obstruction (2019) (0)
Modeling for understanding of coronavirus disease-2019 (COVID-19) spread and design of an isolation room in a hospital (2023) (0)
Longitudinal Replication Of Severe Asthma Exhaled Breath Phenotypes By The U-Biopred Electronic Nose Platform (2016) (0)
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts (2023) (0)
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks (2017) (0)
Leukotriene Receptor Antagonists and 5-Lipoxygenase Inhibitors in Asthma (2000) (0)
Duplicate publication. (2002) (0)
Mouth breathing, dry air, and low water permeation promote inflammation, and activate neural pathways, by osmotic stresses acting on airway lining mucus (2023) (0)
Bromodomain And Extra-Terminal (BET) proteins regulate metabolic and redox function in COPD airway smooth muscle cells (2017) (0)
Late Breaking Abstract - Microbiome-driven clusters in severe asthma derived from induced sputum: identification and stability over time (2019) (0)
M048 Clinical characteristic of severe asthma patients with JAK-STAT pathway activation (2022) (0)
Altered mitochondrial reactive oxygen species (ROS) production in airway smooth muscle cells of severe asthma (2019) (0)
Respiratory andallergic disease. I. (1988) (0)
Lack of a role for bradykinin in inhaled sodium metabisulphite-induced airway microvascular leakage in guinea pigs (1996) (0)
Current Perspectives in Allergy: Contemporary Issues in Clinical Immunology and Allergy: 1 (1983) (0)
Cardio-respiratory outcomes in COPD following ambient exposures to diesel traffic emissions:"Oxford Street 2" (2014) (0)
Severe asthma: the next decade of continuing progress (2019) (0)
The Effect Of A Novel Chemical Probe For BET Bromodomains (JQ1/SGCBD01) Upon Inflammation And Proliferation In Human ASM Cells (2012) (0)
Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor- (cid:1) of induction of airway smooth muscle hyperplasia by (2007) (0)
Phospho-p38 MAPK expression in COPD and asthmatics and in challenged bronchial epithelium (2017) (0)
Lower CC16 Expression in the Airway Is Associated With an Asthma Phenotype and Local and Systemic Type 2 Inflammatory Traits (2023) (0)
Identification of oropharyngeal microbiome-driven asthma and wheezing clusters in children (2022) (0)
Steroid induced osteoporosis: Authors' reply (1992) (0)
Bronchial hyperresponsiveness and lung inflammation induced by allergic immune response and oxidative stress: role of innate and adaptive immune responses (2011) (0)
Effect offrusemide on theinduction andpotentiation ofcough induced byprostaglandin F2o (1992) (0)
Ambient relative humidity-dependent obstructive sleep apnea severity in cold season: A case-control study. (2022) (0)
Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma (2017) (0)
Characterising SARS-CoV-2 transmission via aerosols and effective sampling methods for surveillance (2022) (0)
Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma (2021) (0)
Determinants of Breath Condensate pH in a Large Asthma Cohort: pH as a Potential Biomarker for Identifying Asthma Subpopulations. (2009) (0)
Drug trials. (1998) (0)
Molecular phenotypes of severe asthma (2019) (0)
Multi-Output Regression with Generative Adversarial Networks (MOR-GANs) (2022) (0)
Inhibition of p38 MAPK Activation on Corticosteroid Suppression of Cytokine Release in Severe Asthma. (2009) (0)
IL4 Phenotyping asthma and new treatments (2014) (0)
The first U-BIOPRED sputum handprint of severe asthma (2015) (0)
Short-term exposure to ambient motor vehicle emissions perturb the human circulating miRNA genome (2018) (0)
Abraham (“Abe”) Guz: a life devoted to breathing and breathlessness (2014) (0)
Altered airway epithelial cell landscape in U-BIOPRED severe asthma (2022) (0)
Type-2-low severe asthma endotypes for new treatments: the new asthma frontier (2023) (0)
Adverse roles of mast cell chymase-1 in COPD (2022) (0)
Characteristics of fine and ultrafine aerosols in the London underground. (2022) (0)
role of cyclooxygenase products . bronchoconstriction by frusemide in asthma : Inhibition of sodium metabisulphite induced (2004) (0)
Comprar Pharmacology and Therapeutics of Airway Disease | Kian Fan Chung | 9781420070002 | Informa Healthcare (2008) (0)
Distilled water aerosol causes bronchoconstriction in Basenji-greyhound (BG) dogs (1985) (0)
Roles of real-world evidence in severe asthma treatment: challenges and opportunities (2022) (0)
The Effect of Prior Bronchoconstriction on the Bronchial Response to Inhaled Histamine (1982) (0)
Data on lung and intestinal microbiome after air pollution exposure in ageing rats (2023) (0)
Lipid biomarkers predictive of gastro-oesophageal reflux in adult asthma (2016) (0)
Polymorphisms in Oxidative Stress-related Genes Modify Environmental Effects on Asthma Exacerbations (2023) (0)
A role for PI 3 Kδ in the impairment of glucocorticoid responsiveness in COPD 1 2 (2015) (0)
p38 MAPK, IKK-2 and Oxidative Stress Regulate Histone 3 Serine 10 Phosphorylation in Blood Monocytes and Alveolar Macrophages. (2009) (0)
Silver nanoparticles impair human antimicrobial immune responses (INC6P.353) (2014) (0)
Altered metabolic activity and redox balance are associated with a proliferative phenotype in COPD airway smooth muscle cells. (2020) (0)
Sputum supernatant profiling reveals inflammasome-associated signatures in severe asthmatics in U-BIOPRED (2015) (0)
Subtypes of eosinophilic asthma with discrete gene pathway phenotypes (2019) (0)
Acknowledgments (2012) (0)
Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China (2022) (0)
Eligibility of C-BIOPRED severe asthma cohort for type-2 biologic therapies. (2023) (0)
Phenotyping Asthma : Linking Clinical Features to Biomolecular Pathways (2017) (0)
Effect of Aerosol Histamine on Bronchial Blood Flow in Sheep (1989) (0)
Metered Cryospray Modulates Bronchial Epithelial Gene Expression in Patients with Chronic Obstructive Pulmonary Disease (2020) (0)
Is Oxidative Stress an Important Determinant of Airway Smooth Muscle Cytokine and Chemokine Production (2009) (0)
Comprar Overcoming Steroid Insensitivity in Respiratory Disease | Ian Adcock | 9780470058084 | Wiley (2008) (0)
Discordant use of short‐acting β2 agonists in children and adults with severe, uncontrolled asthma from the U‐BIOPRED cohort (2020) (0)
Occasional review Cytokines in asthma (1999) (0)
Mechanisms of Bronchial Narrowing in Pulmonary Oedema (1981) (0)
Impact of PAHs exposure on exacerbation frequency in asthma using a new grid-scale simulation of PM2.5-PAHs distribution (2020) (0)
Bromodomain and extra-terminal (BET) proteins regulate antioxidant gene expression (2013) (0)
LATE-BREAKING ABSTRACT: Sputum transcriptome analysis yields eosinophilic and non-eosinophilic inflammatory mechanisms in UBIOPRED asthma cohort (2015) (0)
Airways smooth muscle: peptide receptors, ion channels and signal transduction (1996) (0)
Dose-Reponse Curves in vivo in the Investigation of Agonist-Antagonist Reactions in the Tracheobronchial Tree (1981) (0)
Maximal airway plateau responses and eosinophils in cough variant asthma (2004) (0)
2002 North American Referee List (2002) (0)
Fractalkine/CX 3 CL1 production by human airway smooth muscle cells: induction by IFN- (cid:1) and TNF- (cid:2) and regulation by TGF- (cid:3) and corticosteroids (2004) (0)
Long-Acting Inhaled Beta2 Receptor Agonist Drugs (2020) (0)
TLR7 and TLR9-activated inflammation is differentially regulated in asthma (2013) (0)
Circuit with Surfactant Protein-D in the IL-4 and IL-13 Form a Negative Feedback (2006) (0)
Domiciliary fractional exhaled nitric oxide and spirometry in monitoring asthma control and exacerbations. (2023) (0)
Sputum microbiota in Chinese adults with eosinophilic versus non-eosinophilic asthma (2015) (0)
Mouth breathing, dry air, and low water permeation promote upper airway inflammation, activate neural pathways and disrupt clearance by osmotic stresses originating in a water condensation layer above airway lining mucus (2023) (0)
Role of Eosinophil Mitochondrial Function in Severe Eosinophilic Asthma (2023) (0)
Corticosteroid therapy in asthma: are metabolic considerations important? (1992) (0)
Correction to: Research Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function (2021) (0)
Transfer of mitochondria between COPD airway smooth muscle cells (2020) (0)
Risk Factors for Influenza-Induced Exacerbations and Mortality in Non-Cystic Fibrosis Bronchiectasis (2023) (0)
Erratum: Bronchial vasodilation by histamine in sheep: Characterization of receptor subtype (Journal of Applied Physiology (June 1992) 72 (2090-2098)) (1992) (0)
Acknowledgement to Referees (2006) (0)
The current debate concerning ,-agonists in asthma: a review (2005) (0)
Increased Expression Of Aquaporin 5 In Bronchial Glands Of Smokers With Or Without COPD (2010) (0)
Morse-clustering of a Topological Data Analysis Network Identifies Phenotypes of Asthma Based on Blood Gene Expression Profiles (2019) (0)
Eformoterol and bronchial hyperresponsiveness in mild asthma. (1995) (0)

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