Klas Kärre

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Klas Kärre

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Philosophy

Why Is Klas Kärre Influential?

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According to Wikipedia, Klas Kärre is a Swedish immunologist. Kärre received his doctorate in 1981 at Karolinska Institutet and is a professor of molecular immunology at Karolinska Institutet since 1993. In the mid-1980s Kärre discovered one of the mechanisms for how cells of the immune system, natural killer cells , identify their target cells and kill them. The findings were that the NK cells are inhibited by a transplantation antigen, the major histocompatibility complex class I, which prevents NK cells from killing their target cells. When MHC class I is removed from the target cells, they are killed by the NK cells. Kärre named this phenomenon "the missing self hypothesis".

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Klas Kärre's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

In search of the 'missing self': MHC molecules and NK cell recognition. (1990) (2689)
Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy (1986) (2182)
Association of class I major histocompatibility heavy and light chains induced by viral peptides (1989) (976)
Empty MHC class I molecules come out in the cold (1990) (946)
Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism (1985) (776)
Classification of current anticancer immunotherapies (2014) (357)
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. (2009) (328)
NK Cells, MHC Class I Molecules and the Missing Self (2002) (308)
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. (2009) (282)
Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice. (1991) (271)
A New Mechanism of NK Cell Cytotoxicity Activation: The CD40–CD40 Ligand Interaction (1997) (260)
NK cell education: not an on-off switch but a tunable rheostat. (2009) (255)
A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition (2002) (254)
A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. (2004) (251)
Natural killer cell recognition of missing self (2008) (250)
Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice. (1989) (227)
Human NK Cells Selective Targeting of Colon Cancer–Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules (2013) (209)
Effects of Human Cytomegalovirus Infection on Ligands for the Activating NKG2D Receptor of NK Cells: Up-Regulation of UL16-Binding Protein (ULBP)1 and ULBP2 Is Counteracted by the Viral UL16 Protein1 (2003) (203)
Recognition of autologous dendritic cells by human NK cells (1999) (198)
Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. (2012) (189)
Allorecognition by NK cells: nonself or no self? (1992) (187)
Host MHC class I gene control of NK‐cell specificity in the mouse (1997) (186)
Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice (1980) (178)
Recruitment and Activation of Natural Killer (Nk) Cells in Vivo Determined by the Target Cell Phenotype (2000) (175)
Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules (2005) (173)
YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage. (1985) (173)
Killer cells: a functional comparison between natural, immune T-cell and antibody-dependent in vitro systems (1976) (167)
Express yourself or die: peptides, MHC molecules, and NK cells. (1995) (161)
Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand. (1995) (159)
Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene (1997) (158)
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants (2006) (158)
Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. (1997) (156)
Pivotal Role of KARAP/DAP12 Adaptor Molecule in the Natural Killer Cell–mediated Resistance to Murine Cytomegalovirus Infection (2002) (130)
NK cell-sensitive T-cell subpopulation in thymus: inverse correlation to host NK activity (1979) (121)
Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice (1988) (116)
Acquisition of External Major Histocompatibility Complex Class I Molecules by Natural Killer Cells Expressing Inhibitory Ly49 Receptors (2001) (114)
How to recongnize a foreign submarine (1997) (111)
Interferon gamma induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens. (1987) (109)
Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis. (1989) (107)
Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus (2009) (105)
The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I (1994) (105)
Enrichment of CD56dimKIR+CD57+ highly cytotoxic NK cells in tumor infiltrated lymph nodes of melanoma patients (2014) (104)
A Perfect Mismatch (2002) (103)
Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2 (2011) (99)
Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers (2000) (98)
Natural Killer Cells (2010) (94)
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion (2007) (93)
Natural NK-cell targets in the mouse thymus: characteristics of the sensitive cell population. (1979) (92)
Distinct Phenotype and Function of NK Cells in the Pancreas of Nonobese Diabetic Mice (2010) (92)
Missing self recognition by natural killer cells in MHC class I transgenic mice. A 'receptor calibration' model for how effector cells adapt to self. (1995) (92)
Human Cytomegalovirus Strain-Dependent Changes in NK Cell Recognition of Infected Fibroblasts1 (2000) (89)
Loss or mismatch of MHC class I is sufficient to trigger NK cell‐mediated rejection of resting lymphocytes in vivo – role of KARAP/DAP12‐dependent and ‐independent pathways (2004) (88)
Triggering of murine NK cells by CD40 and CD86 (B7-2). (1999) (86)
T cell competition for the antigen‐presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens (1999) (85)
ROLE OF TARGET HISTOCOMPATIBILITY ANTIGENS IN REGULATION OF NATURAL KILLER ACTIVITY: A REEVALUATION AND A HYPOTHESIS1 (1985) (84)
IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression. (1995) (84)
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition. (1998) (83)
T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity1 (2000) (83)
Immunodominance in the CTL response against minor histocompatibility antigens: interference between responding T cells, rather than with presentation of epitopes. (1998) (82)
Identification of wild‐type and mutant p53 peptides binding to HLA‐A2 assessed by a peptide loading‐deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay (1994) (82)
DAP12 Signaling Directly Augments Proproliferative Cytokine Stimulation of NK Cells during Viral Infections1 (2006) (79)
Synergistic effect of IFN‐γ and human cytomegalovirus protein UL40 in the HLA‐E‐dependent protection from NK cell‐mediated cytotoxicity (2001) (77)
Superdominance among immunodominant H-2Kb-restricted epitopes and reversal by dendritic cell-mediated antigen delivery. (1998) (76)
LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients (2003) (76)
Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells (1992) (73)
In vitro NK‐activity and in vivo resistance to leukemia: Studies of beige, beige/nude and wild‐type hosts on C57BL background (1980) (73)
Peptide dependency and selectivity of the NK cell inhibitory receptor Ly‐49C (1999) (72)
EXPERIMENTAL STRATEGIES AND INTERPRETATIONS IN THE ANALYSIS OF CHANGES IN MHC GENE EXPRESSION DURING TUMOUR PROGRESSION (1986) (72)
The Expression of Human Natural Killer Cell Receptors in Early Life (2007) (71)
External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells. (1998) (70)
Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target (1991) (70)
How to recognize a foreign submarine. (1997) (69)
Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant. (1990) (69)
Natural cytotoxicity to human leukemia mediated by mouse non‐t cells (1977) (69)
A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses. (2002) (66)
Assessment of major histocompatibility complex class I interaction with Epstein‐Barr virus and human immunodeficiency virus peptides by elevation of membrane H‐2 and HLA in peptide loading‐deficient cells (1992) (65)
Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes. (1992) (63)
NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients. (2011) (62)
Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants. (1990) (60)
β2 ‐Microglobulin‐deficient NK cells show increased sensitivity to MHC class I‐mediated inhibition, but self tolerance does not depend upon target cell expression of H‐2Kb and Db heavy chains (1998) (60)
Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells. (1997) (59)
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients (2017) (58)
NK cell receptor calibration: effects of MHC class I induction on killing by Ly49Ahigh and Ly49Alow NK cells. (1997) (58)
Skewing of the NK Cell Repertoire by MHC Class I via Quantitatively Controlled Enrichment and Contraction of Specific Ly49 Subsets (2012) (58)
Cytotoxic Thy 1,2-positive blasts with NK-like target selectivity in murine mixed lymphocyte cultures. (1979) (58)
A mutant cell in which association of class I heavy and light chains is induced by viral peptides. (1989) (51)
Herpes Simplex Virus Infection Downmodulates NKG2D Ligand Expression (2009) (50)
The RMA‐S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection (1991) (50)
MHC Class I Recognition by NK Receptors in the Ly49 Family Is Strongly Influenced by the β2-Microglobulin Subunit1 (2001) (49)
Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR‐1/ILT2/CD85j (2006) (48)
Natural killer clones recognize specific soluble HLA class I molecules (1996) (47)
TAP1‐deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity (1996) (46)
Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes. (1996) (46)
Increased Expression of Leukocyte Ig-Like Receptor-1 and Activating Role of UL18 in the Response to Cytomegalovirus Infection1 (2007) (45)
Immunology. A perfect mismatch. (2002) (44)
Expression of CD226 is associated to but not required for NK cell education (2017) (44)
The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. (1998) (44)
Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells. (1997) (43)
Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells (1993) (43)
Microchip Screening Platform for Single Cell Assessment of NK Cell Cytotoxicity (2016) (41)
A weakly tumorigenic phenotype with high mhc class‐i expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma (1990) (41)
Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction (2009) (41)
Studies of sublines selected for loss of HLA expression from an EBV-transformed lymphoblastoid cell line. Changes in sensitivity to cytotoxic T cells activated by allostimulation and natural killer cells activated by IFN or IL-2. (1989) (41)
Innate and adaptive immunity to tumors: IL‐12 is required for optimal responses (2000) (41)
Inhibition of Human NK Cell-Mediated Killing by CD1 Molecules1 (2000) (40)
In vivo tumor cell rejection induced by NK cell inhibitory receptor blockade: Maintained tolerance to normal cells even in the presence of IL‐2 (2010) (40)
NK cells control breast cancer and related cancer stem cell hematological spread (2017) (39)
Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts. (1988) (39)
"Anomalous" Thy-1+ killer cells in allogeneic and F1-anti-parental mixed leukocyte culture. Relation to natural killer cells and allospecific cytotoxic T lymphocytes (1982) (38)
Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides. (1995) (38)
Inhibition of natural killer cell‐mediated bone marrow graft rejection by allogeneic major histocompatibility complex class I, but not class II molecules (1995) (37)
Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition (2019) (36)
Probing Natural Killer Cell Education by Ly49 Receptor Expression Analysis and Computational Modelling in Single MHC Class I Mice (2009) (35)
Natural killer cells and the MHC class I pathway of peptide presentation. (1993) (35)
Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization. (1999) (35)
Selective acceptance of MHC class I-deficient tumor grafts in the brain (1988) (34)
Viral decoy vetoes killer cell (1997) (34)
MHC gene control of the natural killer system at the level of the target and the host. (1991) (33)
Reactivity and Specificity of CD8+ T Cells in Mice with Defects in the MHC Class I Antigen‐Presenting Pathway (1996) (33)
Natural Killer Cell Inhibitory Receptor Expression in Humans and Mice: A Closer Look (2013) (32)
Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice (2010) (32)
DAP12 Signaling Regulates Plasmacytoid Dendritic Cell Homeostasis and Down-Modulates Their Function during Viral Infection1 (2006) (32)
Dynamic Regulation of NK Cell Responsiveness. (2016) (31)
Specificity, Function, and Development of NK Cells (1998) (29)
Reduced expression of major histocompatibility complex class I free heavy chains and enhanced sensitivity to natural killer cells after incubation of human lymphoid lines with β2‐microglobulin (1993) (29)
HLA class I downregulation is associated with enhanced NK‐cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors (2015) (29)
An unexpected petition for pardon (1992) (29)
DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection. (2006) (29)
Clinical Expansion of Cord Blood-derived T Cells for Use as Donor Lymphocyte Infusion After Cord Blood Transplantation (2010) (28)
Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus‐1 infection (2007) (28)
The MHC class I molecule H-2Dp inhibits murine NK cells via the inhibitory receptor Ly49A. (1999) (28)
IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo (2016) (27)
A Structural Basis for CD8+ T Cell-dependent Recognition of Non-homologous Peptide Ligands (2005) (27)
Multiple interactions at the natural killer workshop. (1991) (26)
Structural basis of the differential stability and receptor specificity of H-2Db in complex with murine versus human beta2-microglobulin. (2006) (26)
NK‐ and T‐cell subsets in malignant mesothelioma patients: Baseline pattern and changes in the context of anti‐CTLA‐4 therapy (2019) (25)
Impaired MHC class I (H‐2Dd)‐mediated protection against Ly‐49A+ NK cells after amino acid substitutions in the antigen binding cleft (1998) (25)
Towards a cancer mission in Horizon Europe: recommendations (2020) (24)
Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens (1999) (23)
Recognition of the Major Histocompatibility Complex Restriction Element Modulates CD8+ T Cell Specificity and Compensates for Loss of T Cell Receptor Contacts with the Specific Peptide (1999) (22)
Purified MHC class I molecules inhibit activated NK cells in a cell‐free system in vitro (2001) (21)
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. 1986. (2005) (19)
Incidence and type of tumors induced in C57BL bg/bg mice and +/bg littermates by oral administration of DMBA (1981) (19)
Retuning of Mouse NK Cells after Interference with MHC Class I Sensing Adjusts Self-Tolerance but Preserves Anticancer Response (2015) (19)
Characterization of long‐term mixed donor–donor chimerism after double cord blood transplantation (2010) (17)
NK Cell Inhibitory Receptor Ly-49C Residues Involved in MHC Class I Binding1 (2002) (17)
Altered expression of Ly49 inhibitory receptors on NK cells from MHC class I deficient mice (1997) (16)
Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells (2016) (15)
Effect of IFN‐γ treatment and in vivo passage of murine tumor cell lines on their sensitivity to lymphokine‐activated killef (LAK) cell lysis in vitro; association with H‐2 expression on the target cells (1989) (15)
Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft. (1995) (15)
A Genetic Defect in Mice That Impairs Missing Self Recognition Despite Evidence for Normal Maturation and MHC Class I–Dependent Education of NK Cells (2014) (14)
Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant. (1988) (14)
Natural resistance against tumors grafted into the brain in association with histocompatibility‐class‐I‐antigen expression (1996) (13)
H-2Dp transgene alters natural killer cell specificity at the target and effector cell levels. Comparison with an H-2Dd transgene. (1996) (13)
Role of Major Histocompatibility Complex Class I α1/α2 Domain Polymorphism and In Vivo Expression Pattern in Tumor Resistance: Studies with Transgenic Mice and Lymphoma Cell Transfectants (1993) (12)
NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients. (2010) (12)
THE GENETIC REGULATION OF NK‐ACTIVITY: STUDIES ON CONGENIC MICE WITH B10 OR AKR BACKGROUND (1980) (11)
An active T-cell-independent mechanism enhances MHC class I transcription and expression on a mouse T-cell lymphoma in vivo. (1987) (11)
The uterine cervix--a new member of the family of immunologically exceptional sites? (2003) (11)
Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade (2021) (10)
Role of major histocompatibility complex class-I molecules in tumor rejection (1990) (10)
Clever, cleverer, cleverest (2002) (10)
Increased Cell-Mediated Immune Responses in Patients with Recurrent Herpes Simplex Virus Type 2 Meningitis (2011) (10)
Influence of glycosylphosphatidylinositol‐linked H‐2Dd molecules on target cell protection and natural killer cell specificity in transgenic mice (1996) (9)
‘Hybrid resistance’ against parental tumors: One or several genetic patterns? (1978) (9)
Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin. (2005) (9)
WITHDRAWN: Characterization of Patterns of Immune Cell Infiltration in NSCLC (2020) (9)
Hybrid resistance against a natural killer (NK) cell-resistant lymphoma (YWA) is mediated by a T cell-dependent mechanism. (1982) (9)
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer (2021) (8)
Enhanced H-2 expression and T-cell-dependent rejection after intracerebral transplantation of the murine lymphoma YAC-1. (1989) (8)
THE BEIGE MODEL IN STUDIES OF NATURAL RESISTANCE TO SYNGENEIC, SEMISYNGENEIC, AND PRIMARY TUMORS (1982) (7)
Differential effects on T cell and NK cell development by tissue‐specific expression of H‐2Dd transgene (2000) (7)
Demonstration of natural antibodies in normal rabbit serum with similar specificity pattern as mouse natural killer cells. (1980) (7)
Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences (2016) (6)
Immunology: The footprint of a killer (2000) (6)
The Natural Killer Cell - 'Missing-Self' Recognition Strategy (2011) (6)
Depletion of IL‐2 receptor β‐positive cells protects from diabetes in non‐obese diabetic mice (2016) (5)
The Role of an Exposed Loop in the α2 Domain in the Mouse MHC Class I H‐2Dd Molecule for Recognition by the Monoclonal Antibody 34‐5‐8S and the NK‐Cell Receptor Ly49A (2002) (5)
Lack of F1 anti‐parental resistance in H‐2b/d F1 hybrids devoid of β2‐microglobulin (1997) (4)
Characterization of patterns of immune cell infiltration in non-small cell lung cancer (NSCLC). (2020) (4)
Host H-2 genotype regulates the metastatic ability of H-2-associated variants of B16 melanoma: defense systems screening for absence of self H-2 components by natural killer cells and host-associated homing barrier. (1988) (4)
Constitutive WASp activation leads to abnormal cytotoxic cells with increased response against tumors. (2021) (3)
Increased Frequency and Responsiveness of PSA-Specific T Cells After Allogeneic Hematopoetic Stem-Cell Transplantation (2009) (3)
Specificity, function, and development of NK cells : NK cells: the effector arm of innate immunity (1998) (3)
Soluble and Exosome-Bound α-Galactosylceramide Mediate Preferential Proliferation of Educated NK Cells with Increased Anti-Tumor Capacity (2021) (3)
Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane (2014) (3)
Genetic control of in vitro NK reactivity and its relationship to in vivo tumor resistance. (1980) (3)
PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype (2022) (3)
Incidence and type of tumors induced by DMBA carcinogenesis in H‐2 congenic strains on a B10 background (1983) (3)
Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells (2021) (3)
Clustering of Major Histocompatibility Complex-Class I Molecules in Healthy and Cancer Colon Cells Revealed from Their Nanomechanical Properties. (2021) (3)
Correction: Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane (2015) (2)
Expansion of T-Cells from the Cord Blood Graft as a Predictive Tool for Complications and Outcome of Cord Blood Transplantation (2012) (2)
In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation (2016) (2)
Genetic control of in vitro NK-activity and in vivo resistance to tumors. (1983) (1)
Pillars article: Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 1989. 340: 443-448. (2007) (1)
Expansion of T-cells from the cord blood graft as a predictive tool for complications and outcome of cord blood transplantation. (2012) (1)
PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency (2021) (1)
Transgene induced MHC mismatch results in rapid natural killer cell dependent elimination of lymphoma cells (1990) (1)
Enrichment of KIR+CD57+ highly cytotoxic NK cells in sentinel lymph nodes of melanoma patients (2014) (1)
Natural Killer Cells1 (1981) (1)
Enrichment of KIR+CD57+ highly cytotoxic NK cells in sentinel lymph nodes of melanoma patients (2014) (1)
functional responsiveness of individual natural killer cells The strength of inhibitory input during education quantitatively tunes the (2013) (1)
George Klein (1925–2016) (2017) (1)
Role of major histocompatibility complex class I alpha 1/alpha 2 domain polymorphism and in vivo expression pattern in tumor resistance: studies with transgenic mice and lymphoma cell transfectants. (1993) (1)
Natural Killer Cell Mediated Defence Directed Selectively Against Target Cells Lacking MHC Class I Gene Products (1992) (0)
[Molecular analysis of relationship between oncogene (N-myc and c-src) expression and major histocompatibility complex antigen gene expression in mouse neuroblastoma lines]. (1990) (0)
[Cytotoxic effector mechanism and genetic control of non-immunized hybrid resistance to mouse T cell lymphoma transplanted outside and inside the brain]. (1990) (0)
Distinct Phenotype and Function of NK Cells (2010) (0)
Breakdown of ‘Tolerance’ in the Natural Killer Interaction with H-2 Syngeneic Grafts (1989) (0)
MHC Class I–Dependent Shaping of the NK Cell Ly49 Receptor Repertoire Takes Place Early during Maturation in the Bone Marrow (2022) (0)
Education of natural killer (NK) cells by host MHC class I molecules (ML04) Chairperson: Ko Okumura (2010) (0)
Spatial Immunophenotyping of the Tumor Microenvironment in Non-Small Cell Lung Cancer (2023) (0)
First International Meeting of the Thematic Centre for Immune Modulatory Therapies for Autoimmunity and Cancer (IMTAC) 13–14 June 2011, Ljusterö, Sweden (2012) (0)
Abstract B54: The ability of NK cells to perform missing-self rejection of target cells is quantitatively different between individuals and controlled by MHC class I through a process of education (2011) (0)
Microchip screening platform for assessment of cytotoxic effector cells (2014) (0)
DiversityAllows Maintenance of Maximal Repertoire Thresholds Rather Than Complete Deletion T Cell Tolerance Based on Avidity (2000) (0)
NK cell cytotoxicity mediated by CD40 and CD80 recognition (1997) (0)
Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer. (2023) (0)
[The Nobel Prize for discovery of the cell-mediated immune defense. Significance for clinical medicine]. (1996) (0)
Effects of dimethyl sulfoxide (DMSO) treatment on H-2 expression and susceptibility to NK and CTL mediated lysis of YAC-1 lymphoma and its β2microglobulin (β2M) deficient variant (1988) (0)
Multidisciplinary approaches to enhance BRAF targeted therapy in melanoma (P2092) (2013) (0)
Viral Infection Down-Modulates Their Function during Dendritic Cell Homeostasis and DAP 12 Signaling Regulates Plasmacytoid (2006) (0)
Crystal Structure Of The Murine Class I Major Histocompatibility Complex Of H-2Db, B2-Microglobulin, and a 9-Residue Peptide Derived from rat dopamine beta-monooxigenase (2005) (0)
MHC CLASS-I EXPRESSION IN TRANSPLANTATION TOLERANCE AND PEPTIDE PRESENTATION TO CTL - A MUTANT-CELL THAT FAILS TO PRESENT INTERNALLY DERIVED H-2 RESTRICTED ANTIGENS BUT REMAINS SENSITIVE TO ALLO H-2 SPECIFIC RESPONSES (1989) (0)
Natural Killer Cells (Part 1 of 4) (1981) (0)
This information is current as Dependent Education of NK Cells - for Normal Maturation and MHC Class I Missing Self Recognition Despite Evidence A Genetic Defect in Mice That Impairs (2014) (0)
Ly49ANK Cells via the Inhibitory Receptor The MHC Class I Molecule H-2Dp Inhibits (2013) (0)
Is Counteracted by the Viral UL 16 Protein UL 16-Binding Protein ( ULBP ) 1 and ULBP 2 Receptor of NK Cells : Up-Regulation of on Ligands for the Activating NKG 2 D Effects of Human Cytomegalovirus Infection (2003) (0)
Extending the immune phenotypes of lung cancer: Oasis in the desert (2019) (0)
Proliferative and Cytotoxic Response of Human Natural Killer Cells Exposed to Transporter Associated with Antigen‐Processing‐Deficient Cells (2004) (0)
410 The role of NK cells in WASp related cancer and eczema: Studies on the pathogenesis and possible novel therapies (2016) (0)
in the Pancreas of Nonobese Diabetic Mice Distinct Phenotype and Function of NK Cells (2010) (0)
Is Counteracted by the Viral UL16 Protein UL16-Binding Protein (ULBP)1 and ULBP2 Receptor of NK Cells: Up-Regulation of on Ligands for the Activating NKG2D Effects of Human Cytomegalovirus Infection (2003) (0)
[Molecular analysis of mouse major histocompatibility complex class I gene expression of tumors growing in the brain]. (1989) (0)
THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110 (1998) (0)
Immunodominance in the T-cell recognition of minor histocompatibility antigens A study on naturally eluted peptides (1994) (0)
[Nobel Prize for discovery of the cell-mediated immune defence]. (1996) (0)
Ly49AMurine NK Cells via the Inhibitory Receptor Inhibits p The MHC Class I Molecule H-2D (0)
Role of histocompatibility antigen gene and protooncogene expressions in intracerebral tumorigenicity of mouse neuroblastoma. (1993) (0)
Bone marrow transplantation and graft versus host disease (PP-077) (2010) (0)
A METHOD TO MEASURE MHC CLASS-I-PEPTIDE INTERACTIONS AT THE CELL-SURFACE (1990) (0)
Involved in MHC Class I Binding NK Cell Inhibitory Receptor Ly-49C Residues (2013) (0)
The role of different amino acids in the mouse MHC class I H-2 D-d molecular for protection against killing by Ly49A+ NK cells (1997) (0)
Murine MHC class I H-2Db in complex with human b2-microglobulin and LCMV-derived immunodminant peptide gp33 (2006) (0)
Gut flora and inflammation (WS-067) Chairpersons: Hiroshi Ohno, Kenya Honda (2010) (0)
Natural Killer Cells (Part 2 of 4) (1981) (0)
Cell-Mediated Antigen Delivery-Restricted Epitopes and Reversal by Dendriticb Superdominance Among Immunodominant H-2 K (1998) (0)
A decreased proportion of CD56bright human natural killer cells in cord blood from children that develop early allergy (2008) (0)
Changes in NK Cell Recognition of Infected Human Cytomegalovirus Strain-Dependent (2000) (0)
Long-Term Mixed Donor-Donor Chimerism After Double Cord Blood Transplantation: Advantageous? (2010) (0)
Natural Killer Cells (Part 3 of 4) (1981) (0)
Natural Cytotoxicity Receptors and MHC Initiating Cells : A Role for − Colon Cancer Human NK Cells Selective Targeting of Dieli (2013) (0)
P599 - Reactivity and specificity of CD8+ T cells in MHC class I deficient mice (1996) (0)
[Experimental analysis of anti-tumor cytotoxic mechanism for hybrid resistance to mouse neuroblastoma]. (1990) (0)
Natural Resistance against H-2+ and H-2− Tumor Cells Grafted to the Brain (1989) (0)
[Natural killer cells - a control mechanism against abnormal cells]. (1981) (0)
[A scientist's day-dream or future reality? Specific immunotherapy against cancer]. (1997) (0)
Murine Natural Killer Cells MHC Class I-Specific Receptor Ly49A on External and Internal Calibration of the (2013) (0)

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Other Resources About Klas Kärre

en.wikipedia.org

What Schools Are Affiliated With Klas Kärre?

Klas Kärre is affiliated with the following schools:

Karolinska Institute