Klaus Aktories
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German pharmacologist
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(Suggest an Edit or Addition)Klaus Aktories's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Glucosylation of Rho proteins by Clostridium difficile toxin B (1995) (1035)
- Microinjection of recombinant p21rho induces rapid changes in cell morphology (1990) (673)
- Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton (1995) (596)
- Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1 (1997) (528)
- Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis (2003) (500)
- The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins(*) (1995) (489)
- Botulinum C2 toxin ADP-ribosylates actin (1986) (486)
- Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase (2000) (416)
- Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins (2004) (387)
- Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria (2009) (358)
- GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure (2000) (345)
- Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O (2001) (311)
- The N-terminal Domain of Pseudomonas aeruginosaExoenzyme S Is a GTPase-activating Protein for Rho GTPases* (1999) (298)
- Structure and mode of action of clostridial glucosylating toxins: the ABCD model. (2008) (278)
- Bacterial protein toxins that modify host regulatory GTPases (2011) (264)
- The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3. (1989) (259)
- Clostridium difficile binary toxin CDT (2013) (253)
- Bacterial cytotoxins: targeting eukaryotic switches (2005) (243)
- A Common Motif of Eukaryotic Glycosyltransferases Is Essential for the Enzyme Activity of Large Clostridial Cytotoxins* (1998) (226)
- Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling. (1998) (220)
- Photorhabdus luminescens Toxins ADP-Ribosylate Actin and RhoA to Force Actin Clustering (2010) (217)
- Clostridium botulinum type C produces a novel ADP‐ribosyltransferase distinct from botulinum C2 toxin (1987) (209)
- Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells* (2002) (203)
- Clostridium difficile toxin B acts on the GTP-binding protein Rho. (1994) (200)
- Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function. (2007) (197)
- Auto-catalytic Cleavage of Clostridium difficile Toxins A and B Depends on Cysteine Protease Activity* (2007) (194)
- Bacterial toxins that target Rho proteins. (1997) (193)
- Inactivation of Ras by Clostridium sordellii Lethal Toxin-catalyzed Glucosylation (*) (1996) (189)
- Deamidation of Cdc42 and Rac by Escherichia coliCytotoxic Necrotizing Factor 1: Activation of c-Jun N-Terminal Kinase in HeLa Cells (1999) (186)
- Rho-modifying C3-like ADP-ribosyltransferases. (2004) (184)
- Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT) (2011) (180)
- Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin* (1997) (178)
- Cellular Uptake of Clostridium botulinum C2 Toxin Requires Oligomerization and Acidification* (2000) (178)
- Clostridium perfringens iota toxin ADP‐ribosylates skeletal muscle actin in Arg‐177 (1987) (176)
- Clostridium difficile Toxin Biology. (2017) (173)
- Rho GTPases as Targets of Bacterial Protein Toxins (2000) (171)
- Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein (2000) (171)
- Rho proteins: targets for bacterial toxins. (1997) (170)
- ADP-ribosylated actin caps the barbed ends of actin filaments. (1988) (167)
- Novel bacterial ADP-ribosylating toxins: structure and function (2014) (164)
- A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells (1983) (164)
- An Inhibitory Role of Rho in the Vasopressin-mediated Translocation of Aquaporin-2 into Cell Membranes of Renal Principal Cells* (2001) (162)
- Regulation of Mitogen-Activated Protein Kinases in Cardiac Myocytes through the Small G Protein Rac1 (2001) (161)
- The Ras-related Small GTP-binding Protein RhoB Is Immediate-early Inducible by DNA Damaging Treatments (*) (1995) (160)
- The N-Terminal Part of the Enzyme Component (C2I) of the BinaryClostridium botulinum C2 Toxin Interacts with the Binding Component C2II and Functions as a Carrier System for a Rho ADP-Ribosylating C3-Like Fusion Toxin (1998) (159)
- Bacterial toxins that modify the actin cytoskeleton. (2002) (158)
- Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis (2010) (158)
- Structural basis for the function of Clostridium difficile toxin B. (2005) (157)
- Low pH-induced Formation of Ion Channels by Clostridium difficile Toxin B in Target Cells* (2001) (155)
- The Rho-deamidating cytotoxic necrotizing factor 1 from Escherichia coli possesses transglutaminase activity. Cysteine 866 and histidine 881 are essential for enzyme activity. (1998) (155)
- Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosum. (1992) (154)
- The amino‐terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small‐molecular‐weight GTP‐binding proteins (1999) (152)
- Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets. (1994) (148)
- Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177. (1988) (145)
- Botulinum ADP-ribosyltransferase C3. Purification of the enzyme and characterization of the ADP-ribosylation reaction in platelet membranes. (1988) (144)
- Cellular Uptake of Clostridium difficile Toxin B (2003) (142)
- Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins. (1989) (142)
- Role of Rho and Rho kinase in the activation of volume‐regulated anion channels in bovine endothelial cells (1999) (141)
- Uncoupling of alpha-adrenoceptor-mediated inhibition of human platelet adenylate cyclase by N-ethylmaleimide. (1982) (138)
- Actin as target for modification by bacterial protein toxins (2011) (137)
- Noise Can Induce Bimodality in Positive Transcriptional Feedback Loops Without Bistability (2010) (135)
- Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A (2006) (134)
- Clostridium novyi α-Toxin-catalyzed Incorporation of GlcNAc into Rho Subfamily Proteins* (1996) (132)
- Clostridium botulinum C3 ADP-ribosyltransferase. (1992) (131)
- The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile. (1995) (130)
- Mechanism of Tc toxin action revealed in molecular detail (2014) (130)
- The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia (2016) (130)
- Requirement of Rac activity for maintenance of capillary endothelial barrier properties. (2004) (129)
- ADP-ribosylation of actin by clostridial toxins (1989) (129)
- Characterization of the Enzymatic Component of the ADP-Ribosyltransferase Toxin CDTa from Clostridium difficile (2001) (127)
- RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes (2011) (126)
- Lgt: a Family of Cytotoxic Glucosyltransferases Produced by Legionella pneumophila (2008) (125)
- Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells. (2001) (125)
- The Host Cell Chaperone Hsp90 Is Essential for Translocation of the Binary Clostridium botulinum C2 Toxin into the Cytosol* (2003) (124)
- Role of Rho proteins in carbachol‐induced contractions in intact and permeabilized guinea‐pig intestinal smooth muscle. (1996) (122)
- Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice (2002) (120)
- Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes (1995) (119)
- Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase. (1991) (119)
- ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin. (1988) (116)
- A syringe-like injection mechanism in Photorhabdus luminescens toxins (2013) (116)
- Human alpha-defensins inhibit Clostridium difficile toxin B. (2008) (114)
- Structure and action of the binary C2 toxin from Clostridium botulinum. (2006) (114)
- Binding of Clostridium botulinum C2 Toxin to Asparagine-linked Complex and Hybrid Carbohydrates* (2000) (114)
- C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins (2007) (113)
- Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation (2009) (112)
- The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells (2017) (111)
- Purification of the 22 kDa protein substrate of botulinum ADP‐ribosyltransferase C3 from porcine brain cytosol and its characterization as a GTP‐binding protein highly homologous to the rho gene product (1989) (111)
- Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins. (2004) (107)
- Characterization of the Catalytic Site of the ADP-Ribosyltransferase Clostridium botulinum C2 Toxin by Site-directed Mutagenesis* (1998) (103)
- Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes. Formation of cation-selective channels and inhibition of channel function by chloroquine. (1994) (103)
- Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress (2001) (102)
- Monoglucosylation of RhoA at Threonine 37 Blocks Cytosol-Membrane Cycling* (1999) (100)
- Inhibition of FcRI-mediated Activation of Rat Basophilic Leukemia Cells by Clostridium difficile Toxin B (Monoglucosyltransferase) (*) (1996) (100)
- Bacterial protein toxins targeting rho GTPases. (2000) (100)
- Botulinum C2 toxin ADP-ribosylates actin and disorganizes the microfilament network in intact cells. (1987) (99)
- The Yersinia pseudotuberculosis Cytotoxic Necrotizing Factor (CNFY) Selectively Activates RhoA* (2004) (97)
- Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 Exoenzyme in the Rho-Guanine Nucleotide Dissociation Inhibitor-1 Complex* (2003) (97)
- Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells. (1997) (92)
- Clostridium difficile Glucosyltransferase Toxin B-essential Amino Acids for Substrate Binding* (2007) (92)
- Mechanisms of the cytopathic action of actin‐ADP‐ribosylating toxins (1992) (91)
- Cholesterol-dependent Pore Formation of Clostridium difficile Toxin A* (2006) (90)
- A Novel C3-like ADP-ribosyltransferase fromStaphylococcus aureus Modifying RhoE and Rnd3* (2001) (90)
- Membrane Translocation of Binary Actin-ADP-Ribosylating Toxins from Clostridium difficile and Clostridium perfringens Is Facilitated by Cyclophilin A and Hsp90 (2011) (89)
- Cellular Uptake of the Clostridium perfringens Binary Iota-Toxin (2001) (89)
- An Essential Role for Rac/Cdc42 GTPases in Cerebellar Granule Neuron Survival* (2001) (89)
- The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. (2000) (88)
- Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence (2014) (88)
- Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B (2011) (88)
- Inhibition of hamster fat cell adenylate cyclase by prostaglandin E1 and epinephrine: Requirement for GTP and sodium ions (1979) (87)
- Hijacking of Rho GTPases during bacterial infection. (2013) (86)
- Proteasomal Degradation of Cytotoxic Necrotizing Factor 1-Activated Rac (2002) (86)
- Actin Involvement in Exocytosis from PC12 Cells: Studies on the Influence of Botulinum C2 Toxin on Stimulated Noradrenaline Release (1989) (85)
- Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins. (1995) (85)
- Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes vis α‐adrenoceptors (1981) (84)
- Activation of Rho GTPases by Escherichia coli Cytotoxic Necrotizing Factor 1 Increases Intestinal Permeability in Caco-2 Cells (1998) (82)
- Clostridium difficile toxin B inhibits carbachol‐induced force and myosin light chain phosphorylation in guinea‐pig smooth muscle: role of Rho proteins (1998) (82)
- Agents That Inhibit Rho, Rac, and Cdc42 Do Not Block Formation of Actin Pedestals in HeLa Cells Infected with Enteropathogenic Escherichia coli (1998) (79)
- ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotide. (1987) (79)
- Neuropeptide Y inhibits renin release by a pertussis toxin-sensitive mechanism. (1987) (79)
- Recognition of RhoA by Clostridium botulinum C3 Exoenzyme* (2000) (78)
- Ni-mediated inhibition of human platelet adenylate cyclase by thrombin. (1984) (77)
- Actin Filaments Facilitate Insulin Activation of the Src and Collagen Homologous/Mitogen-activated Protein Kinase Pathway Leading to DNA Synthesis and c-fos Expression* (1998) (75)
- Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton. (1997) (75)
- Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site. (1984) (74)
- LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins (2014) (74)
- Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils. (1988) (73)
- Clostridial Rho-inhibiting protein toxins. (2005) (73)
- The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases. (2001) (73)
- Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain. (1997) (72)
- The Binary Clostridium botulinum C2 Toxin as a Protein Delivery System (2002) (72)
- The Host Cell Chaperone Hsp90 Is Necessary for Cytotoxic Action of the Binary Iota-Like Toxins (2004) (72)
- Pasteurella multocida Toxin-induced Activation of RhoA Is Mediated via Two Families of Gα Proteins, Gαq and Gα12/13* (2005) (72)
- Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro. (1991) (70)
- Cell-free synthesis and characterization of a novel cytotoxic pierisin-like protein from the cabbage butterfly Pieris rapae. (2011) (70)
- Microbial toxins and the glycosylation of rho family GTPases. (2000) (69)
- Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms. (1985) (69)
- Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation (2008) (68)
- ADP-ribosylation of actin isoforms by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin. (1990) (68)
- Identification of the Region of Rho Involved in Substrate Recognition by Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1)* (1999) (68)
- Insecticidal Toxin Complex Proteins from Xenorhabdus nematophilus (2011) (67)
- Bacterial toxins : tools in cell biology and pharmacology (1997) (67)
- Auto-ADP-ribosylation of Pseudomonas aeruginosaExoS* (2002) (66)
- Involvement of a Conserved Tryptophan Residue in the UDP-Glucose Binding of Large Clostridial Cytotoxin Glycosyltransferases* (2000) (66)
- Identification of the C-terminal Part of BordetellaDermonecrotic Toxin as a Transglutaminase for Rho GTPases* (1999) (66)
- The C Terminus of Component C2II ofClostridium botulinum C2 Toxin Is Essential for Receptor Binding (2000) (66)
- Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordellii. (1996) (65)
- Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function. (1997) (65)
- RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells. (2002) (64)
- Interaction of Clostridium botulinum C2‐toxin with lipid bilayer membranes and vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo (2001) (64)
- Mechanisms and components involved in adenylate cyclase inhibition by hormones. (1984) (64)
- Conformational changes and reaction of clostridial glycosylating toxins. (2008) (63)
- ADP-ribosylation of platelet actin by botulinum C2 toxin. (1986) (63)
- Inhibition of adenylate cyclase. (1985) (62)
- Autocatalytic Processing of Clostridium difficile Toxin B (2009) (62)
- Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen (2011) (62)
- The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis. (2003) (62)
- Processing of Clostridium difficile toxins. (2008) (62)
- Recombinant Yersinia YopT Leads to Uncoupling of RhoA-Effector Interaction (2001) (60)
- Domain organization of Legionella effector SetA (2012) (60)
- Rho GTPases and Phosphoinositide 3-Kinase Organize Formation of Branched Dendrites* (2004) (59)
- Dose-dependent inhibition by oral contraceptives of the pituitary to release LH and FSH in response to stimulation with LH-RH+. (1976) (59)
- Bacterial toxin and effector glycosyltransferases. (2010) (59)
- Chimeric Clostridial Cytotoxins: Identification of the N-Terminal Region Involved in Protein Substrate Recognition (1998) (58)
- In vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases. (1995) (58)
- Biological Activity of a C-Terminal Fragment ofPasteurella multocida Toxin (2001) (58)
- Neosynthesis and Activation of Rho by Escherichia coli Cytotoxic Necrotizing Factor (CNF1) Reverse Cytopathic Effects of ADP-ribosylated Rho* (1999) (57)
- Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain. (2003) (57)
- Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B (2012) (57)
- The Cytotoxic Necrotizing Factors from Yersinia pseudotuberculosis and from Escherichia coli Bind to Different Cellular Receptors but Take the Same Route to the Cytosol (2007) (56)
- A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins (2013) (55)
- Rho-ADP-ribosylating exoenzyme from Bacillus cereus. Purification, characterization, and identification of the NAD-binding site. (1995) (54)
- Rho family GTPase inhibition reveals opposing effects of mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival (2006) (54)
- Molecular Characteristics of Clostridium perfringens TpeL Toxin and Consequences of Mono-O-GlcNAcylation of Ras in Living Cells* (2012) (54)
- Cholesterol- and Sphingolipid-rich Microdomains Are Essential for Microtubule-based Membrane Protrusions Induced by Clostridium difficile Transferase (CDT)* (2011) (54)
- Regulation of Somatodendritic GABAA Receptor Channels in Rat Hippocampal Neurons: Evidence for a Role of the Small GTPase Rac1 (2000) (53)
- Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure (2015) (53)
- Inhibition of Rac GTPase triggers a c‐Jun‐ and Bim‐dependent mitochondrial apoptotic cascade in cerebellar granule neurons (2005) (53)
- Identification of the Cellular Receptor of Clostridium spiroforme Toxin (2012) (53)
- Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT (2015) (53)
- The ras-related protein Ral is monoglucosylated by Clostridium sordellii lethal toxin. (1996) (52)
- FK506‐binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells (2012) (52)
- Nonmuscle actin ADP‐ribosylated by botulinum C2 toxin caps actin filaments (1989) (52)
- Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes. (1991) (52)
- Islet‐activating protein prevents nicotinic acid‐induced GTPase stimulation and GTP but not GTPγS‐induced adenylate cyclase inhibition in rat adipocytes (1983) (51)
- Isotype-specific Degradation of Rac Activated by the Cytotoxic Necrotizing Factor 1* (2004) (51)
- Bidirectional attack on the actin cytoskeleton. Bacterial protein toxins causing polymerization or depolymerization of actin. (2012) (50)
- Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins. (2006) (50)
- Differential expression of the small GTP-binding proteins RhoA, RhoB, Cdc42u and Cdc42b in developing rat neocortex. (1999) (50)
- Nicotinic acid inhibits adipocyte adenylate cyclase in a hormone—like manner (1980) (50)
- Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases. (2001) (49)
- ADP-ribosylation of actin causes increase in the rate of ATP exchange and inhibition of ATP hydrolysis. (1989) (49)
- Fast neurotransmitter release regulated by the endocytic scaffold intersectin (2013) (48)
- Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterization. (2003) (48)
- Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo. (2003) (48)
- Crystal structure of the C3bot–RalA complex reveals a novel type of action of a bacterial exoenzyme (2005) (47)
- G13-dependent Activation of MAPK by Thyrotropin* (2008) (47)
- Interaction of mastoparan with the low molecular mass GTP‐binding proteins rho/rac (1991) (47)
- Clostridium difficile Binary Toxin CDT Induces Clustering of the Lipolysis-Stimulated Lipoprotein Receptor into Lipid Rafts (2013) (46)
- Bacterial glycosyltransferase toxins (2015) (46)
- Role of actin depolymerization in the surfactant secretory response of alveolar epithelial type II cells. (1999) (46)
- Bacillus sphaericus mosquitocidal toxin (MTX) and pierisin: the enigmatic offspring from the family of ADP‐ribosyltransferases (2006) (45)
- Rac and Phosphatidylinositol 3-Kinase Regulate the Protein Kinase B in FcεRI Signaling in RBL 2H3 Mast Cells1 (2001) (45)
- Cleavage of Escherichia coli Cytotoxic Necrotizing Factor 1 Is Required for Full Biologic Activity (2009) (45)
- Stimulation of a low Km GTPase by inhibitors of adipocyte adenylate cyclase. (1982) (45)
- Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton. (2018) (45)
- Clostridial actin-ADP-ribosylating toxins. (1992) (45)
- Molecular mode of action of the large clostridial cytotoxins. (2000) (45)
- ADP-ribosylation of small GTP-binding proteins by Bacillus cereus. (1992) (44)
- Influence of botulinum C2 toxin on F-actin and N-formyl peptide receptor dynamics in human neutrophils (1989) (44)
- The uptake machinery of clostridial actin ADP-ribosylating toxins – a cell delivery system for fusion proteins and polypeptide drugs (2002) (43)
- Activation of Gαi and Subsequent Uncoupling of Receptor-Gαi Signaling by Pasteurella multocida Toxin* (2008) (42)
- ADP‐ribosylation of Rho proteins inhibits sperm motility (1993) (42)
- Botulinum ADP‐ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP‐ribosylates low molecular mass GTP‐binding proteins (1987) (42)
- Characterization of the Catalytic Domain ofClostridium novyi Alpha-Toxin (2000) (41)
- Clostridium botulinum C2 Toxin (2003) (40)
- The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation (2014) (40)
- Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc− variants are prevented by islet‐activating protein (1983) (40)
- Botulinum toxin‐induced ADP‐ribosylation and inhibition of exocytosis are unrelated events (1988) (39)
- Modulation of Host Cell Gene Expression through Activation of STAT Transcription Factors by Pasteurella multocida Toxin* (2007) (39)
- Structure and mode of action of a mosquitocidal holotoxin. (2008) (39)
- NAD-binding site of the C3-like ADP-ribosyltransferase from Clostridium limosum. (1993) (39)
- Lu/BCAM Adhesion Glycoprotein Is a Receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) (2014) (39)
- Nerve growth factor triggers microfilament assembly and paxillin phosphorylation in human B lymphocytes (1995) (38)
- Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line. (1983) (38)
- ADP-ribosylation of gelsolin-actin complexes by clostridial toxins. (1992) (38)
- Interaction of the Rho-ADP-ribosylating C3 Exoenzyme with RalA* (2002) (37)
- Change of the Donor Substrate Specificity of Clostridium difficile Toxin B by Site-directed Mutagenesis* (2005) (37)
- Action of Pasteurella multocida Toxin Depends on the Helical Domain of Gαq* (2004) (37)
- Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs. (1995) (37)
- ADP-Ribosylating Toxins (1992) (37)
- The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP‐ribosyltransferases (2014) (37)
- Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin. (1988) (37)
- Cysteine-specific ADP-ribosylation of actin. (1994) (37)
- Inhibition of Calcium Release-activated Calcium Current by Rac/Cdc42-inactivating Clostridial Cytotoxins in RBL Cells* (2000) (36)
- Evidence for two GTPases activated by thrombin in membranes of human platelets. (1986) (36)
- Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis. (2003) (36)
- Bacterial Protein Toxins (2000) (36)
- Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT) (2016) (36)
- Probing the action of Clostridium difficile toxin B in Xenopus laevis oocytes. (1994) (35)
- Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells (2017) (35)
- Analysis of the catalytic site of the actin ADP‐ribosylating Clostridium perfringens iota toxin (1996) (35)
- Structure-function analysis of the Rho-ADP-ribosylating exoenzyme C3stau2 from Staphylococcus aureus. (2002) (35)
- Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins. (2015) (35)
- Isolation and characterization of a Clostridium botulinum C2 toxin-resistant cell line: evidence for possible involvement of the cellular C2II receptor in growth regulation (1995) (35)
- Botulinum Neurotoxins (2013) (34)
- Activation of human neutrophils by mastoparan. Reorganization of the cytoskeleton, formation of phosphatidylinositol 3,4,5-trisphosphate, secretion up-regulation of complement receptor type 3 and superoxide anion production are stimulated by mastoparan. (1992) (34)
- Inositol Hexakisphosphate-dependent Processing of Clostridium sordellii Lethal Toxin and Clostridium novyi α-Toxin* (2011) (34)
- Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin. (2008) (34)
- Integrins and adhesion molecules: Tumour necrosis factor-α-mediated dyscohesion of epithelial cells is associated with disordered expression of cadherin/β-catenin and disassembly of actin filaments (1995) (34)
- GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists (1979) (34)
- Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos (2015) (33)
- New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin. (2011) (33)
- The ADP-ribosylating Mosquitocidal Toxin from Bacillus sphaericus (2002) (33)
- Regulation of adenylate cyclase activity in hamster adipocytes (1980) (33)
- Pasteurella multocida toxin is a potent activator of anti‐apoptotic signalling pathways (2010) (33)
- Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins (2013) (33)
- Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR spectroscopy. (2003) (33)
- Region of Elongation Factor 1A1 Involved in Substrate Recognition by Legionella pneumophila Glucosyltransferase Lgt1 (2009) (32)
- Heparin uncouples alpha 2-adrenoceptors from the Gi-protein in membranes of human platelets. (1988) (32)
- Effects of Clostridium botulinum C2 toxin and cytochalasin D on in vitro invasiveness, motility and F-actin content of a murine T-lymphoma cell line. (1995) (32)
- Active site mutation of the C3-like ADP-ribosyltransferase from Clostridium limosum--analysis of glutamic acid 174. (1996) (31)
- ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells. (1997) (31)
- Formation of a biologically active toxin complex of the binary Clostridium botulinum C2 toxin without cell membrane interaction. (2006) (31)
- Activation of phospholipase D1 by ADP-ribosylated RhoA. (2003) (31)
- His1205 and His1223 are essential for the activity of the mitogenic Pasteurella multocida toxin. (2003) (31)
- Cholera toxin inhibits prostaglandin E1 but not adrenaline‐induced stimulation of GTP hydrolysis in human platelet membranes (1982) (30)
- Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction. (1991) (30)
- Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR)* (2015) (30)
- Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. (2006) (30)
- New Method To Generate Enzymatically DeficientClostridium difficile Toxin B as an Antigen for Immunization (2000) (29)
- The hamster adipocyte adenylate cyclase system. II. Regulation of enzyme stimulation and inhibition by monovalent cations. (1981) (29)
- Guanine nucleotides and monovalent cations increase agonist affinity of prostaglandin E2 receptors in hamster adipocytes. (1982) (29)
- The C Terminus of YopT Is Crucial for Activity and the N Terminus Is Crucial for Substrate Binding (2003) (29)
- Signal Transducer and Activator of Transcription-5 Mediates Neuronal Apoptosis Induced by Inhibition of Rac GTPase Activity* (2012) (29)
- Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins. (2018) (29)
- Rundown of somatodendritic N‐methyl‐D‐aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA (1999) (29)
- Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens (2011) (29)
- Inactivation of the Elongation Factor Tu by Mosquitocidal Toxin-Catalyzed Mono-ADP-Ribosylation (2002) (28)
- ADP‐ribosylation by Clostridium botulinum C3 exoenzyme increases steady‐state GTPase activities of recombinant rhoA and rhoB proteins (1992) (28)
- Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins. (2009) (28)
- Structure of the mosquitocidal toxin from Bacillus sphaericus. (2006) (28)
- Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin (2018) (28)
- Clostridium botulinum C2 toxin: Low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells (2003) (28)
- Clostridium botulinum C2 toxin--new insights into the cellular up-take of the actin-ADP-ribosylating toxin. (2004) (28)
- ADP-ribosylation of the GTP-binding protein Rho by Clostridium limosum exoenzyme affects basal, but not N-formyl-peptide-stimulated, actin polymerization in human myeloid leukaemic (HL60) cells. (1994) (27)
- Exchange of glutamine-217 to glutamate of Clostridium limosum exoenzyme C3 turns the asparagine-specific ADP-ribosyltransferase into an arginine-modifying enzyme. (2006) (27)
- Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13. (2005) (27)
- Pasteurella Multocida Toxin Prevents Osteoblast Differentiation by Transactivation of the MAP-Kinase Cascade via the Gαq/11 - p63RhoGEF - RhoA Axis (2013) (26)
- Neuronal Apoptosis Induced by Selective Inhibition of Rac GTPase versus Global Suppression of Rho Family GTPases Is Mediated by Alterations in Distinct Mitogen-activated Protein Kinase Signaling Cascades* (2015) (26)
- Molecular biology of Pasteurella multocida toxin. (2012) (25)
- Sodium regulation of hormone-sensitive adenylate cyclase. (1984) (25)
- Inhibition of protein isoprenylation impairs rho-regulated early cellular response to genotoxic stress. (2000) (25)
- Elongation Factor 1A Is the Target of Growth Inhibition in Yeast Caused by Legionella pneumophila Glucosyltransferase Lgt1* (2012) (25)
- Morphological alteration of Xenopus oocytes induced by valine‐14 p21rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP‐ribosyltranferase (1990) (24)
- Localization of the C3-Like ADP-Ribosyltransferase from Staphylococcus aureus during Bacterial Invasion of Mammalian Cells (2006) (24)
- Pasteurella multocida toxin (PMT) activates RhoGTPases, induces actin polymerization and inhibits migration of human dendritic cells, but does not influence macropinocytosis. (2006) (24)
- Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells (2016) (24)
- Studies on the active-site structure of C3-like exoenzymes: involvement of glutamic acid in catalysis of ADP-ribosylation. (1995) (23)
- Inhibition of histamine release from rat mast cells by botulinum C2 toxin. (1987) (23)
- Interaction of small G proteins with photoexcited rhodopsin (1990) (23)
- Inhibition of Fc epsilon-RI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase) (1996) (23)
- The Rho-deamidating Cytotoxic Necrotizing Factor 1 fromEscherichia coli Possesses Transglutaminase Activity (1998) (23)
- The hamster adipocyte adenylate cyclase system. I. Regulation of enzyme stimulation and inhibition by manganese and magnesium ions. (1981) (23)
- Clostridium botulinum C2 Toxin (2008) (23)
- Rho-modifying bacterial protein toxins. (2015) (23)
- The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression (2010) (23)
- Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors. (2007) (22)
- Inhibition of the contraction of the isolated longitudinal muscle of the guinea-pig ileum by botulinum C2 toxin: Evidence for a role of G/F-actin transition in smooth muscle contraction (1989) (22)
- Functional Characterization of an Extended Binding Component of the Actin-ADP-Ribosylating C2 Toxin Detected in Clostridium botulinum Strain (C) 2300 (2010) (22)
- Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila. (2010) (22)
- A role for Rho in receptor- and G protein-stimulated phospholipase C Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B (1996) (22)
- Botulinum C2 toxin treatment increases the G-actin pool in intact chicken cells: a model for the cytopathic action of actin-ADP-ribosylating toxins. (1989) (22)
- Inhibition of cytochalasin D-stimulated G-actin ATPase by ADP-ribosylation with Clostridium perfringens iota toxin. (1990) (22)
- A Cell-permeable Fusion Toxin as a Tool to Study the Consequences of Actin-ADP-ribosylation Caused by the Salmonella enterica Virulence Factor SpvB in Intact Cells* (2007) (22)
- Inhibition of the glucosyltransferase activity of clostridial Rho/Ras‐glucosylating toxins by castanospermine (2008) (22)
- Tumour necrosis factor-α-mediated dyscohesion of epithelial cells is associated with disordered expression of cadherin/β-catenin and disassembly of actin filaments (1995) (21)
- Exchange of a Single Amino Acid Switches the Substrate Properties of RhoA and RhoD toward Glucosylating and Transglutaminating Toxins* (2006) (21)
- TcdA1 of Photorhabdus luminescens: electrophysiological analysis of pore formation and effector binding. (2013) (21)
- Lysine and Polyamines Are Substrates for Transglutamination of Rho by the BordetellaDermonecrotic Toxin (2001) (21)
- Interaction of recombinant rho A GTP‐binding proteins with photoexcited rhodopsin (1990) (21)
- Pertussis toxin attenuates angiotensin II-induced vasoconstriction and inhibition of renin release (1985) (21)
- Regulation by Rho family GTPases of IL–1 receptor induced signaling: C3‐like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL‐2 gene expression (2001) (20)
- Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins (2018) (20)
- Pasteurella multocida Toxin Activates Various Heterotrimeric G Proteins by Deamidation (2010) (20)
- Actin-gelsolin interaction. (1994) (20)
- Endoproteolytic Processing of RhoA by Rce1 Is Required for the Cleavage of RhoA by Yersinia enterocolitica Outer Protein T (2006) (20)
- Clostridium botulinum C2 Toxin Delays Entry into Mitosis and Activation of p34cdc2Kinase and cdc25-C Phosphatase in HeLa cells (1999) (20)
- Specific role of RhoC in tumor invasion and metastasis (2017) (20)
- Aminoacyl-tRNA-Charged Eukaryotic Elongation Factor 1A Is the Bona Fide Substrate for Legionella pneumophila Effector Glucosyltransferases (2011) (20)
- Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells (2017) (19)
- Change in Substrate Specificity of Cytotoxic Necrotizing Factor Unmasks Proteasome-independent Down-regulation of Constitutively Active RhoA* (2007) (19)
- Bacterial Cytotoxins Target Rho GTPases (1998) (19)
- Novel receptors for bacterial protein toxins. (2015) (19)
- Cytotoxic glucosyltransferases of Legionella pneumophila. (2013) (19)
- Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins (1994) (19)
- Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways (1997) (19)
- Actin ADP‐ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F‐actin (2017) (19)
- Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling* (2012) (19)
- Insecticidal Toxin Complexes from Photorhabdus luminescens. (2017) (18)
- Autoregulatory control of actin synthesis in cultured rat hepatocytes (1991) (18)
- Adenosine receptor-mediated stimulation of GTP hydrolysis in adipocyte membranes. (1982) (18)
- Effector Glycosyltransferases in Legionella (2011) (18)
- Insecticidal Toxin Complex Proteins from Xenorhabdus nematophilus: Structure and Pore Formation (2011) (18)
- Interaction of ADP‐ribosylated actin with actin binding proteins (2001) (18)
- Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells (2017) (18)
- Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes via alpha-adrenoceptors. (1981) (18)
- Synergistic inhibition of human platelet adenylate cyclase by stable GTP analogs and epinephrine. (1983) (18)
- Somatostatin-induced stimulation of a high-affinity GTPase in membranes of S49 lymphoma cyc- and H21a variants. (1983) (18)
- Inhibitory coupling of hormone and neurotransmitter receptors to adenylate cyclase. (1983) (17)
- ADP-ribosyltransferase type A from turkey erythrocytes modifies actin at Arg-95 and Arg-372. (1995) (17)
- Human peptide α‐defensin‐1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT (2020) (17)
- Stimulation of high-affinity GTPase by trypsin and trypsin-like proteinases in membranes of human platelets. (1988) (17)
- Molecular Mechanisms of Action of the Large Clostridial Cytotoxins (2000) (17)
- Sodium regulation of opioid agonist binding is potentiated by pertussis toxin. (1984) (17)
- Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells. (2001) (17)
- Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT (2014) (16)
- High- and Small-Molecular-Weight GTP-Binding Proteins in Zymogen Granule Membranes of Rat Pancreatic Acinar Cells (1992) (16)
- ADP-ribosylation of Rho proteins by Clostridium botulinum exoenzyme C3 is influenced by phosphorylation of Rho-associated factors. (1994) (16)
- Photorhabdus luminescens toxins TccC3 and TccC5: insecticidal ADP-ribosyltransferases that modify threonine and glutamine. (2015) (16)
- C3stau, a new member of the family of C3-like ADP-ribosyltransferases. (2002) (16)
- 11 – Regulation of Platelet Cyclic AMP Formation (1985) (16)
- Na+ amplifies adenosine receptor-mediated inhibition of adipocyte adenylate cyclase. (1981) (16)
- Clostridium Botulinum C3 Exoenzyme and C3-Like Transferases (2000) (16)
- Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) Induces Apoptosis in LNCaP Prostate Cancer Cells (2013) (16)
- De-ADP-ribosylation actin by Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin. (1990) (16)
- Regulation of actin synthesis in rat hepatocytes by cytoskeletal rearrangements. (1996) (15)
- Gelsolin-actin complex is target for ADP-ribosylation by Clostridium botulinum C2 toxin in intact human neutrophils. (1993) (15)
- Crystal structure of the Clostridium limosum C3 exoenzyme (2008) (15)
- New class of microbial toxins ADP-ribosylates actin (1987) (15)
- Action of Pasteurella multocida toxin depends on the helical domain of Galphaq. (2004) (15)
- Ultrastructural changes of lung capillary endothelium in response to botulinum C2 toxin. (1997) (15)
- Clostridium difficile Toxin B as a Probe for Rho GTPases (2008) (15)
- Pasteurella multocida Toxin as a Transporter of Non-Cell-Permeating Proteins (2013) (14)
- GTPases and Actin as Targets for Bacterial Toxins (1993) (14)
- ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80. (1992) (14)
- Morphological alterations of Xenopus oocytes induced by valine-14 p21rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP-ribosyltransferase. (1990) (14)
- ADP-ribosylation and de-ADP-ribosylation of the rho protein by Clostridium botulinum exoenzyme C3. Regulation by EDTA, guanine nucleotides and pH. (1991) (14)
- Influence of Clostridium botulinum C2 toxin on FcɛRI-mediated secretion and tyrosine phosphorylation in RBL cells (1998) (14)
- Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils. (1991) (13)
- Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin (1998) (13)
- The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B (2018) (13)
- Signal transformation mediated by membrane receptors for hormones and neurotransmitters. (1982) (13)
- Differentiation-induced increase in Clostridium botulinum C3 exoenzyme-catalyzed ADP-ribosylation of the small GTP-binding protein Rho. (1994) (13)
- Two-site autoinhibition of the ADP-ribosylating mosquitocidal toxin (MTX) from Bacillus sphaericus by its 70-kDa ricin-like binding domain. (2004) (13)
- Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca2+ signaling in CD8+ T cells (2004) (13)
- Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis. (2005) (13)
- The actin-ADP-ribosylating Clostridium botulinum C2 toxin. (2004) (13)
- Posttranslational isoprenylation of rho protein is a prerequisite for its interaction with mastoparan and other amphiphilic agents. (1992) (12)
- Microinjection of ADP-ribosylated actin inhibits actin synthesis in hepatocyte-hepatoma hybrid cells. (1996) (12)
- Noncanonical G-Protein-Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin (2014) (12)
- Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state (2020) (12)
- Effects of Clostridium botulinum C2 toxin-induced depolymerisation of actin on degranulation of suspended and attached mast cells (1997) (12)
- Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A (2017) (12)
- Inhibition of adenylate cyclase and stimulation of a high affinity GTPase by the antilipolytic agents, nicotinic acid, acipimox and various related compounds. (1983) (12)
- Cholera toxin does not impair hormonal inhibition of adenylate cyclase and concomitant stimulation of a GTPase in adipocyte membranes. (1982) (12)
- ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin. (1993) (12)
- The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase (2018) (11)
- Differentiation properties of renal collecting duct cells in culture. (1986) (11)
- Effects of Clostridium difficile toxin B on activation of rat peritoneal mast cells (1997) (11)
- Differential role of actin in lung endothelial and epithelial barrier properties in perfused rabbit lungs. (1996) (11)
- Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin (2015) (10)
- The actin and Rho‐modifying toxins PTC3 and PTC5 of Photorhabdus luminescens: enzyme characterization and induction of MAL/SRF‐dependent transcription (2015) (10)
- Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT (2020) (10)
- Tumour necrosis factor-alpha-mediated dyscohesion of epithelial cells is associated with disordered expression of cadherin/beta-catenin and disassembly of actin filaments. (1995) (10)
- EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin (2016) (10)
- Modification of plant Rac/Rop GTPase signalling using bacterial toxin transgenes. (2013) (10)
- Differentiation properties of renal collecting duct cells in culture (1986) (10)
- Rho GTPase-activating toxins: cytotoxic necrotizing factors and dermonecrotic toxin. (2000) (9)
- Strain-alleviation model of ADP-ribosylation (2013) (9)
- Self-cutting to kill: new insights into the processing of Clostridium difficile toxins. (2007) (9)
- A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors. (2003) (9)
- Inactivation of the guanine nucleotide regulatory site mediating inhibition of the adenylate cyclase in hamster adipocytes (1982) (9)
- Effects of Large Clostridial Cytotoxins on Activation of RBL 2H3-hm1 Mast Cells Indicate Common and Different Roles of Rac in FcεRI and M1-Receptor Signaling (2003) (9)
- Disturbing Gtp-Binding Protein Function Through Microinjection Into The Visual Cell Of Limulus (1992) (9)
- Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP‐2 pathway (2019) (8)
- Engineering Photorhabdus luminescens toxin complex (PTC) into a recombinant injection nanomachine (2019) (8)
- Enhancement of Clostridium botulinum C3-catalysed ADP-ribosylation of recombinant rhoA by sodium dodecyl sulfate. (1993) (8)
- Botulinum neurotoxin and tetanus toxin: edited by Lance L. Simpson, Academic Press, 1989. $89.00 (xiii + 422 pages) ISBN 0 12 644445 5 (1990) (8)
- Characterization of the glucosyltransferase activity of Legionella pneumophila effector SetA (2018) (8)
- Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL (2018) (8)
- Anion secretion evoked by Pasteurella multocida toxin across rat colon. (2008) (8)
- From cosubstrate similarity to inhibitor diversity--inhibitors of ADP-ribosyltransferases from kinase inhibitor screening. (2011) (8)
- Formation of Nanotube-Like Protrusions, Regulation of Septin Organization and Re-guidance of Vesicle Traffic by Depolymerization of the Actin Cytoskeleton Induced by Binary Bacterial Protein Toxins. (2016) (8)
- Clostridium perfringens, Clostridium difficile, and Other Clostridium Species (2010) (8)
- Islet-activating protein impairs α2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase (1983) (7)
- Acceleration of the adipocyte adenylate cyclase turn-off reaction by inhibitory hormonal factors. (1982) (7)
- EhRho1, a RhoA-Like GTPase of Entamoeba histolytica, Is Modified by Clostridial Glucosylating Cytotoxins (2006) (7)
- A cysteine protease–like domain enhances the cytotoxic effects of the Photorhabdus asymbiotica toxin PaTox (2018) (7)
- Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-κB Response (2020) (7)
- Separation of the 24 kDa substrate for botulinum C3 ADP-ribosyltransferase and the cholera toxin ADP-ribosylation factor. (1988) (7)
- Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication (2019) (7)
- TNF-α induces dyscohesion of epithelial cells. Association with disassembly of actin filaments (1995) (7)
- Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva. (2019) (7)
- Mode of inhibition of renin release by angiotensin II. (1985) (6)
- Pasteurella multocida : molecular biology, toxins and infection (2012) (6)
- Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins (2020) (6)
- Cytotoxic effects by microinjection of ADP-ribosylated skeletal muscle G-actin in PtK2 cells in the absence ofClostridium perfringens iota toxin (1996) (6)
- ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. (2016) (6)
- [The effect of different types of oral contraceptives upon ovarian function (author's transl)]. (1976) (6)
- A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice (2015) (6)
- Purification and activity of the Rho ADP-ribosylating binary C2/C3 toxin. (2006) (5)
- Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control. (2002) (5)
- ADP-ribosylating and glucosylating toxins as tools to study secretion in RBL cells. (1997) (5)
- Proteasomal Degradation of Cytotoxic Necrotizing Factor (2002) (5)
- 14 Bacterial Protein Toxins as Tools in Cell Biology and Pharmacology (2004) (5)
- A novel C3-like ADP-ribosyltransferase produced by Clostridium limosum (1992) (5)
- Rho-modifying bacterial protein toxins from Photorhabdus species. (2016) (5)
- Involvement of N‐glycans in binding of Photorhabdus luminescens Tc toxin (2021) (5)
- Involvement of Osteocytes in the Action of Pasteurella multocida Toxin (2018) (5)
- Characterization of the ADP-ribosylation of actin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin. (1990) (5)
- Clostridium botulinum ADP‐Ribosyltransferase C3 (2008) (5)
- Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin. (2010) (5)
- Clostridial ADP-ribosyltransferases — Modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins (2004) (5)
- ADP-Ribosylation of Actin by Botulinum C2 Toxin (1987) (4)
- Identification of the catalytic site of clostridial ADP-ribosyltransferases. (1997) (4)
- Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins. (2016) (4)
- Correction: Lu/BCAM Adhesion Glycoprotein Is a Receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) (2014) (4)
- ADP-ribosylation of an approximately 70-kilodalton protein of Klebsiella pneumoniae (1996) (4)
- cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology—tribute to Karl H. Jakobs (2019) (4)
- Clostridium botulinum C2 Toxin and C. botulinum C3 ADP-Ribosyltransferase (1994) (4)
- "Switch to kill, switch to survive" – bacterial toxins modifying Rho GTPases (2009) (4)
- Toxins as tools (2015) (3)
- Cell-free synthesis and characterization of a novel cytotoxic pierisin-like protein from the cabbage butter fl y Pieris rapae (2011) (3)
- Inhibitory regulation of adenylate cyclase by prostaglandins. (1983) (3)
- Intracellular plasma membrane guidance of Photorhabdus asymbiotica toxin is crucial for cell toxicity (2015) (3)
- Glucosylating and Deamidating Bacterial Protein Toxins (2003) (3)
- Molecular Biology of Clostridial ADP-Ribosyltransferases and Their Substrates (1993) (3)
- Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells (2018) (3)
- Mucosal Vaccines (2012) (3)
- Insecticidal Toxin Complex Proteins from Xenorhabdus (2011) (2)
- Another surprise in receptor binding of C. difficile toxins (2022) (2)
- Isolated nerve terminals as a model system for the study of Botulinum and Tetanus toxins. (1997) (2)
- Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication (2017) (2)
- Bacterial Protein Toxins Acting on Small GTPases (2014) (2)
- Molecular Mechanism of Action of Clostridium difficile Toxins A and B (1997) (2)
- 1 Elongation factor 1 A is the target of growth inhibition in yeast caused by Legionella pneumophila glucosyltransferase Lgt 1 (2012) (2)
- [ADP ribosylation of actin--a cytotoxic principle of bacterial toxins]. (1991) (2)
- Further contributions to an improved pertussis vaccine: I. Molecular mechanisms of pertussis toxin. (1984) (1)
- CHAPTER 59 – Toxins as tools (2006) (1)
- Clostridial glucosylating toxins (2009) (1)
- Inhibitory modulation of adenylate cyclase (1984) (1)
- [The cAMP system and bacterial toxins]. (1983) (1)
- Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase. (2022) (1)
- Histophilus somni (2020) (1)
- CZostridium dimcile Toxin B Acts on the GTP-binding Protein Rho (2001) (1)
- Interaction of the Clostridium difficile Binary Toxin CDT and its Host Cell Receptor LSR* (2015) (1)
- Large clostridial cytotoxins modifying small GTpases: structural aspects (2015) (1)
- Semaphorins or Frizzled –it is the receptor that direct the action of clostridial glucosylating toxins (2020) (1)
- Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins (2022) (1)
- Inhibition of FceRI-mediated Activation of Rat Basophilic Leukemia Cells by Clostridium difficile Toxin (1996) (1)
- CONTRASTING EFFECTS OF COMBINED AND SEQUENTIAL ORAL CONTRACEPTIVES ON LH-RH-STIMULATED RELEASE OF LH AND FSH AS COMPARED TO MINIPILLS (1975) (1)
- ADP-ribosylation of actin (1990) (1)
- Solution structure of exoenzyme S (2005) (1)
- Role of hormone-sensitive GTPases in adenylate cylase regulation. (1984) (1)
- Bacterial Protein Toxins: Rho-activating toxins and growth regulation (2005) (1)
- Antibodies Directed Against GalNAc- and GlcNAc-O-Tyrosine Posttranslational Modifications - a New Tool for Glycoproteomic Detection. (2023) (1)
- Clostridium difficile binary toxin (CDT) is recognized by the TLR2/6 heterodimer to induce an NF-κB response (2020) (1)
- CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF ALPHA-TOXIN FROM CLOSTRIDIUM NOVYI (2008) (0)
- Crystal structure of the catalytic domain of the mosquitocidal toxin from Bacillus sphaericus, mutant E195Q (2006) (0)
- low quality crystal structure of the transport component C2-II of the C2-toxin from Clostridium botulinum (2006) (0)
- LP40: THE ROLE OF IL-10 AND C3 TOXIN IN NERVE REGENERATION IN AN END-TO-SIDE NERVE REPAIR MODEL (2010) (0)
- Crystal structure of the catalytic domain of the mosquitocidal toxin from Bacillus sphaericus, mutant E197Q (2006) (0)
- cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology—tribute to Karl H. Jakobs (2019) (0)
- Molecular mechanisms of bacterial toxins acting on the cytoskeleton (1995) (0)
- C3: A Novel Botulinum ADP-Ribosyltransferase Modifies a Putative 21 kDa G-Protein (1989) (0)
- Differential rrole o of a actin iin llung e endothelial a and e epithelial b barrier properties iin p perfused rrabbit llungs (1996) (0)
- Treatment of ovarian cancer with modified anthrax toxin (2022) (0)
- Role of host cell chaperones in cellular uptake of binary clostridial enterotoxins (2016) (0)
- ADP-ribosylation of actin by Clostridium perfringens iota toxin and turkey erythrocyte ADP-ribosyltransferase A: effects on profilin-regulated nucleotide exchange and ATPase activity (1996) (0)
- Perspectives Series: Host/Pathogen Interactions Bacterial Toxins That Target Rho Proteins (1997) (0)
- Cytotoxic Necrotizing Factors: Rho-Activating Toxins from Escherichia coli. (2004) (0)
- Faculty Opinions recommendation of Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. (2003) (0)
- Systems Biology (2013) (0)
- C.difficile toxb differenially effects intrinsic and gap-stimulated GTPase of RHO proteins (1995) (0)
- CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION (2008) (0)
- Crystal Structure of TcdA1 (2014) (0)
- From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins (2022) (0)
- From black boxes to defined structure–function relationships (2002) (0)
- Acceleration of the adipocyte aden: by inhibitory hormonal factors (antilipolytic agents/cyclic AMP/guanine nucleotide site/guanosine t (2016) (0)
- Bacterial Toxins (2020) (0)
- Volker HeLa cells Kinase and cdc 25C Phosphatase in cdc 2 Entry into Mitosis and Activation of p 34 C 2 Toxin Delays Clostridium botulinum (1999) (0)
- Modification of the GTP-binding RHO proteins byC. difficile toxin A and B (1995) (0)
- Actin-ADP-ribosylating toxins as pharmacological tools (1990) (0)
- Liver regeneration and hepatic microsomal changes in rats administered cyclosporin A (1987) (0)
- Adenine nucleotides regulate ADP-ribosylation of membrane-bound actin and actin-binding to membranes. (1994) (0)
- Clostridium botulinum C3 exoezyme like ADP-ribosyltransferases (2002) (0)
- Crystal Structure of TcdB2-TccC3 (2014) (0)
- Photorhabdus asymbiotica toxin PaTox: A new bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins (2016) (0)
- Referees 1997 (1997) (0)
- Crystal structure of the enzymatic component C2-I of the C2-toxin from Clostridium botulinum at pH 3.0 (mut-S361R) (2006) (0)
- Probing the Actin Cytoskeleton by Clostridium botulinum C2 Toxin and Clostridium perfringens lota Toxin (2008) (0)
- Characterization of the glucosyltransferase activity of Legionella pneumophila effector SetA (2018) (0)
- In vivo and in vitro desensitization of nicotinic acid-induced adipocyte adenylate cyclase inhibition (1982) (0)
- Nerve Growth Factor Triggers Microfilament Assembly and Paxillirt Phosphorylation in Human B Lymphocytes (2003) (0)
- 130: THE ROLE OF IL-10 AND C3 TOXIN IN NERVE REGENERATION IN AN END-TO-SIDE NERVE REPAIR MODEL (2011) (0)
- Acknowledgment of Reviewers, 2017 (2017) (0)
- Clostridium botulinum C2 toxin as a protein transport system (2002) (0)
- Contents, Vol. 84, 1987 (1987) (0)
- Further contributions to an improved pertussis vaccine: II. New findings in the development of a pertussis vaccine. (1984) (0)
- ADP-ribosylation of actin from the green algaChara corallina byClostridium botulinum C2 toxin andClostridium perfringens iota toxin (1996) (0)
- Acknowledgment to reviewers—2017 (2017) (0)
- Photorhabdus Luminescens Toxins use a Novel Syringe-Like Injection Mechanism for Cell Entry (2013) (0)
- Thyrotropin-receptor signalling in follicular carcinoma cells: Evidence for G13-dependent ERK1/2 stimulation via EGF-receptor transactivation (2005) (0)
- LSR is the host cell receptor for clostridial iota-like toxins (2012) (0)
- Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes (1988) (0)
- Proteinsof Non-Cell-Permeating Pasteurella multocida Toxin as a (2014) (0)
- The priority program Signal Pathways to the Cytoskeleton and Bacterial Pathogenesis (SPP1150). (2011) (0)
- Faculty Opinions recommendation of Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta. (2004) (0)
- Docking and virtual screening of novel inhibitors for mono-ADP-ribosylating toxins (2011) (0)
- Small GTPases (2020) (0)
- Clostridium spiroforme Toxin Identification of the Cellular Receptor of (2012) (0)
- CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND MANGANESE ION (2008) (0)
- Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells (2017) (0)
- Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin (2018) (0)
- Actin‐ADP‐Ribosylating Toxins: Cytotoxic Mechanisms of Clostridium botulinum C2 Toxin and Clostridium perfringens lota Toxin (2008) (0)
- Photorhabdus Luminescens Toxin complex (TCC) a recombinant injection nano-machine – delivery of recombinant Yersinia enterocolitica YopT (2019) (0)
- l(nteraetisn of mastsparan with t&e low molecular mass 'IF-binding proteins rhdrac (1991) (0)
- The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells (2017) (0)
- Effects of different types of oral contraceptives on ovarian function (1976) (0)
- Legionella pneumophila glucosyltransferase Lgt1 N293A with UDP-Glc (2010) (0)
- The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB (2021) (0)
- Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion (2005) (0)
- CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND CALCIUM ION (2008) (0)
- Substrate specificity of Pasteurella multocida toxin for (cid:1) subunits of heterotrimeric G proteins for (2013) (0)
- Activation of human neutrophils by mastoparan (2005) (0)
- Preface for Anaerobe - Special issue on Clostpath9. (2016) (0)
- Toxinology of clostridial toxins (1997) (0)
- Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form (2010) (0)
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What Schools Are Affiliated With Klaus Aktories?
Klaus Aktories is affiliated with the following schools:
