Konrad Hochedlinger
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Developmental Biology
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Biology
Konrad Hochedlinger's Degrees
- Bachelors Biology University of Vienna
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(Suggest an Edit or Addition)Konrad Hochedlinger's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state (2007) (2319)
- Disease-Specific Induced Pluripotent Stem Cells (2008) (2194)
- Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. (2007) (1751)
- Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells (2010) (1169)
- Induced Pluripotent Stem Cells Generated Without Viral Integration (2008) (914)
- Immortalization eliminates a roadblock during cellular reprogramming into iPS cells (2009) (868)
- Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. (2008) (864)
- Ectopic Expression of Oct-4 Blocks Progenitor-Cell Differentiation and Causes Dysplasia in Epithelial Tissues (2005) (837)
- Induced pluripotency: history, mechanisms, and applications. (2010) (794)
- A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells (2012) (788)
- The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. (2013) (772)
- Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells (2010) (770)
- Epigenetic Instability in ES Cells and Cloned Mice (2001) (732)
- Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette (2009) (693)
- Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. (2011) (660)
- Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy (2002) (614)
- Epigenetic reprogramming and induced pluripotency (2009) (600)
- Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells (2011) (563)
- A high-efficiency system for the generation and study of human induced pluripotent stem cells. (2008) (554)
- Monoclonal mice generated by nuclear transfer from mature B and T donor cells (2002) (546)
- Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming (2009) (505)
- Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. (2013) (498)
- Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells (2009) (495)
- Guidelines and techniques for the generation of induced pluripotent stem cells. (2008) (495)
- Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells (2006) (475)
- Nuclear reprogramming and pluripotency (2006) (456)
- Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells (2009) (424)
- Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei (2002) (419)
- Oct4 expression is not required for mouse somatic stem cell self-renewal. (2007) (407)
- Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. (2004) (393)
- Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells (2008) (387)
- Chromatin Connections to Pluripotency and Cellular Reprogramming (2011) (383)
- Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2 (1999) (382)
- Harnessing the potential of induced pluripotent stem cells for regenerative medicine (2011) (369)
- Chromatin dynamics during cellular reprogramming (2013) (360)
- Reprogramming of a melanoma genome by nuclear transplantation. (2004) (350)
- Reprogramming of Neural Progenitor Cells into Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 Expression (2008) (344)
- Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc (2009) (342)
- Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells (2009) (325)
- Hallmarks of pluripotency (2015) (322)
- Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming (2019) (290)
- Reprogramming to recover youthful epigenetic information and restore vision (2020) (273)
- X-Chromosome inactivation in cloned mouse embryos. (2000) (266)
- Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. (2012) (243)
- A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. (2010) (242)
- Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. (2014) (235)
- Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. (2012) (230)
- Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. (2003) (230)
- The histone chaperone CAF-1 safeguards somatic cell identity (2015) (228)
- A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs (2015) (224)
- ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. (2006) (219)
- A reprogrammable mouse strain from gene-targeted embryonic stem cells (2010) (208)
- Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. (2012) (206)
- Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming (2019) (200)
- Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. (2013) (193)
- Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells (2017) (185)
- α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells. (2016) (181)
- Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea (2014) (178)
- Nuclear cloning of embryonal carcinoma cells. (2004) (172)
- Nuclear transplantation, embryonic stem cells and the potential for cell therapy. (2003) (158)
- Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells (2012) (158)
- Harnessing the potential of induced pluripotent stem cells for regenerative medicine. (2011) (150)
- Sox2 marks epithelial competence to generate teeth in mammals and reptiles (2013) (147)
- The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine (2015) (136)
- Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate. (2018) (136)
- Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells (2012) (134)
- Nuclear transplantation: lessons from frogs and mice. (2002) (123)
- Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. (2003) (122)
- Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis (2002) (113)
- The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. (2012) (112)
- Cross-regulation of the Nanog and Cdx2 promoters (2009) (112)
- Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. (2014) (108)
- Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming. (2016) (105)
- Induced pluripotent stem cells and reprogramming: seeing the science through the hype (2009) (102)
- Lineage conversion induced by pluripotency factors involves transient passage through an iPS cell stage (2015) (99)
- Nuclear cloning, stem cells, and genomic reprogramming. (2002) (98)
- Small molecules facilitate rapid and synchronous iPSC generation (2014) (94)
- New advances in iPS cell research do not obviate the need for human embryonic stem cells. (2007) (92)
- Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming (2014) (88)
- Nanog Is Dispensable for the Generation of Induced Pluripotent Stem Cells (2014) (83)
- The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. (2013) (80)
- Induced Pluripotency and Epigenetic Reprogramming. (2015) (80)
- Defining Hematopoietic Stem and Progenitor Cell Turnover by Analysis of Histone 2B-GFP Dilution (2008) (79)
- Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling (2018) (77)
- Fibroblast-Derived Induced Pluripotent Stem Cells Show No Common Retroviral Vector Insertions (2009) (67)
- Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming (2017) (67)
- Early TCR Expression and Aberrant T Cell Development in Mice with Endogenous Prerearranged T Cell Receptor Genes1 (2007) (65)
- Sox2 Suppresses Gastric Tumorigenesis in Mice. (2016) (64)
- When fibroblasts MET iPSCs. (2010) (64)
- Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors (2018) (64)
- Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium (2013) (63)
- PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. (2015) (62)
- Efficient Generation of iPS Cells from Skeletal Muscle Stem Cells (2011) (60)
- The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. (2019) (59)
- DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. (2017) (56)
- Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling (2018) (56)
- Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation (2014) (55)
- Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation. (2017) (55)
- Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs. (2014) (55)
- Reduced MEK inhibition preserves genomic stability in naïve human ES cells (2018) (51)
- X chromosome choice occurs independently of asynchronous replication timing (2005) (51)
- A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2 (2016) (49)
- T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell (2010) (48)
- Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. (2018) (47)
- Renewed proliferation in adult mouse cochlea and regeneration of hair cells (2019) (46)
- Direct in vivo VH to JH rearrangement violating the 12/23 rule (2005) (45)
- An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition. (2018) (43)
- A variant CRISPR-Cas9 system adds versatility to genome engineering (2013) (42)
- Failure to replicate the STAP cell phenomenon (2015) (42)
- Induced pluripotency of mouse and human somatic cells. (2008) (39)
- Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate (2018) (39)
- Nuclear cloning, epigenetic reprogramming and cellular differentiation. (2005) (38)
- Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells (2016) (38)
- Stem cells: iPS cells under attack (2011) (37)
- Oct 4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal (35)
- Stem cells assessed (2012) (34)
- Reprogramming: identifying the mechanisms that safeguard cell identity (2019) (32)
- Emerging roles of the histone chaperone CAF-1 in cellular plasticity. (2017) (31)
- Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo (2019) (28)
- Nuclear cloning, epigenetic reprogramming, and cellular differentiation. (2004) (27)
- Modeling Rett Syndrome with Stem Cells (2010) (26)
- Position-Dependent Silencing of Germline Vβ Segments on TCRβ Alleles Containing Preassembled VβDJβCβ1 Genes (2010) (26)
- Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice (2017) (26)
- Sox 2 + Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp 5 + Progenitors (2012) (23)
- On the cloning of animals from terminally differentiated cells (2007) (23)
- Without a trace? PiggyBac-ing toward pluripotency (2009) (19)
- TCRβ Feedback Signals Inhibit the Coupling of Recombinationally Accessible Vβ14 Segments with DJβ Complexes (2009) (18)
- gPS navigates germ cells to pluripotency. (2009) (18)
- Distinct and Combinatorial Functions of Jmjd 2 b / Kdm 4 b and Jmjd 2 c / Kdm 4 c in Mouse Embryonic Stem Cell Identity (2014) (17)
- Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming (2019) (17)
- Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells. (2016) (15)
- Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium (2013) (15)
- De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency (2019) (15)
- Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation. (2013) (14)
- Chromatin-state barriers enforce an irreversible mammalian cell fate decision. (2021) (13)
- Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells (2021) (12)
- Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells (2018) (11)
- DUSP 9 Modulates DNA Hy pomethylation in Female Mouse Pluripotent Stem Cells (10)
- Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency (2015) (10)
- PRC 2 Is Required to Maintain Expression of the Maternal Gtl 2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells (2015) (9)
- Chromatin state barriers enforce an irreversible mammalian cell fate decision (2021) (9)
- From MYOD1 to iPS cells (2010) (9)
- Strategies to induce nuclear reprogramming. (2006) (8)
- Rearranging the chromatin for pluripotency (2013) (7)
- things to know before jumping on the iPS bandwagon (2008) (6)
- Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior (2021) (6)
- Correction for Blelloch et al., Inaugural Article: Nuclear cloning of embryonal carcinoma cells, PNAS 2004 101:13985-13990 (2004) (6)
- NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia (2022) (5)
- Embryonic Stem Cells: Testing the Germ-Cell Theory (2011) (4)
- Novel Roles for SUMOylation in Cellular Plasticity. (2018) (4)
- Brain versus brawn (2006) (4)
- Your inner healers. (2010) (4)
- Reproductive biology: Stem cells bear eggs (2012) (4)
- Mentorship in Science: Response to AlShebli et al., Nature Communications 2020 (2021) (4)
- Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming. (2023) (3)
- A Gutsy Way to Grow: Intestinal Stem Cells as Nutrient Sensors (2011) (3)
- Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer (2021) (3)
- The Histone Chaperone CAF-1 Sustains Myeloid Lineage Identity (2020) (2)
- Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity (2022) (2)
- Erratum: Nuclear cloning of embryonal carcinoma cells (Proceedings of the National Academy of Sciences of the United States of America (September 28, 2004) 101:39 (13985-13990)) (2004) (2)
- Corrigendum: Failure to replicate the STAP cell phenomenon (2015) (1)
- Characterization And Differentiation In Photoreceptors Of Retina-derived Induced Pluripotent Stem Cells (2012) (1)
- Position-Dependent Silencing of Germline V beta Segments on TCR beta Alleles Containing Preassembled V beta DJ beta C beta 1 Genes (2010) (1)
- Balancing work and life: a conversation with Konrad Hochedlinger. Interview by Majlinda Lako and Susan Daher. (2009) (1)
- ISSCR 2013: Back to Bean Town (2013) (1)
- Derivation and long-term propagation of mouse embryonic stem cells (2017) (1)
- Wnt / ß-catenin activation by epigenetically aberrant stroma drives myelodysplastic syndrome (2017) (1)
- Correction for Miyoshi et al., Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells (2016) (0)
- Corrections and Retraction (2004) (0)
- Resource Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming Graphical (0)
- Corrigendum: Hallmarks of pluripotency (2015) (0)
- Transcription factor-induced epigenetic reprogramming (2008) (0)
- Unlocking the Promise of Stem Cells (2013) (0)
- regular education receiving no special help, a recent epidemiological study found these disorders to be up to three times more prevalent than thought. (2011) (0)
- Prerearranged T Cell Receptor Genes Development in Mice with Endogenous Early TCR Expression and Aberrant T Cell (2007) (0)
- I N ormal commitment but impaired maturation of cardiomyocytes from induced pluripotent stem cells (2009) (0)
- EMBRYONIC STEM CELLS AND PLURIPOTENCY (2008) (0)
- Dissecting the Mechanisms of Cellular Reprogramming (2011) (0)
- Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro (2023) (0)
- An Intermediate Pluripote nt State Controlled by MicroRNAs Is Required for theNaive-to-PrimedStem Cell Transition Graphical (2018) (0)
- Meeting Report ISSCR 2013: Back to Bean Town (2013) (0)
- Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo (2019) (0)
- Konrad Hochedlinger: the new kid of nuclear reprogramming. (2007) (0)
- PRC 2 Is Required to Maint ain Expression of the Maternal Gtl 2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells Graphical (2015) (0)
- Generation of Induced Pluripotent Stem Cells (2012) (0)
- Response to Letters from Daley et al. and Ellis et al. (2009) (0)
- a-Ketoglutarate Accelerat es the Initial Differentiation of Primed Human Pluripotent Stem Cells Graphical (2016) (0)
- Resource Disease-Specific Induced Pluripotent Stem Cells (0)
- REPROGRAMMING OF ADULT CELLS INTO EMBRYONIC CELLS (2008) (0)
- PS1-69 Inducible STAT1 protein in mice (2010) (0)
- Sox 2 Suppresses Gastric T umorigenesis in Mice Graphical Abstract Highlights (0)
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