Kristian Helin

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Kristian Helin is affiliated with the following schools: Institute of Cancer Research, Stanford University, University of Copenhagen

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Kristian Helin

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Philosophy

Kristian Helin's Degrees

PhD Molecular Biology University of Copenhagen
Masters Biochemistry University of Copenhagen
Bachelors Biology University of Copenhagen

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Kristian Helin's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. (2006) (1302)
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development (2007) (1234)
EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer (2003) (1176)
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (2011) (960)
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. (2007) (897)
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity (2004) (862)
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. (2001) (787)
Transcriptional regulation by Polycomb group proteins (2013) (762)
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 (2006) (732)
Molecular mechanisms and potential functions of histone demethylases (2012) (718)
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation (2007) (713)
Role of TET enzymes in DNA methylation, development, and cancer (2016) (682)
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008) (644)
Apaf-1 is a transcriptional target for E2F and p53 (2001) (631)
A model for transmission of the H3K27me3 epigenetic mark (2008) (628)
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F (1992) (618)
Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009) (589)
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells (2010) (579)
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. (2013) (575)
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. (1993) (545)
E2F target genes: unraveling the biology. (2004) (540)
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3 (2007) (535)
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures (1997) (531)
The E2F family: specific functions and overlapping interests (2004) (527)
The retinoblastoma protein binds to a family of E2F transcription factors (1993) (493)
Regulation of cell proliferation by the E2F transcription factors. (1998) (491)
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (1993) (485)
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein (1993) (476)
Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization (1999) (445)
Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor (2008) (438)
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. (2005) (425)
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. (2009) (422)
Histone lysine demethylases as targets for anticancer therapy (2013) (412)
Cyclin E-induced S phase without activation of the pRb/E2F pathway. (1997) (400)
Chromatin proteins and modifications as drug targets (2013) (396)
Polycomb group protein-mediated repression of transcription. (2010) (392)
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. (1995) (390)
The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation (2005) (382)
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies (2014) (377)
Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide. (2014) (368)
A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation (2014) (363)
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. (2013) (355)
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas (2017) (355)
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase (1999) (351)
Histone demethylases in development and disease. (2010) (349)
Polycomb complexes act redundantly to repress genomic repeats and genes. (2010) (348)
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression (1996) (346)
Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity (2004) (341)
Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development (2002) (337)
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer (2016) (327)
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. (2008) (326)
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes (2010) (324)
BLUEPRINT to decode the epigenetic signature written in blood (2012) (320)
Induction of DNA synthesis and apoptosis are separable functions of E2F-1. (1997) (305)
Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation. (2019) (302)
DNA methylation: TET proteins—guardians of CpG islands? (2012) (299)
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. (2013) (294)
Chromatin repressive complexes in stem cells, development, and cancer. (2014) (294)
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. (2000) (291)
Histone methyltransferases in cancer. (2010) (290)
E2F7, a novel E2F featuring DP‐independent repression of a subset of E2F‐regulated genes (2003) (275)
The E2F transcription factors: key regulators of cell proliferation. (2000) (268)
Loss of Geminin induces rereplication in the presence of functional p53 (2004) (268)
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. (2006) (248)
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. (2007) (248)
The emerging functions of histone demethylases. (2008) (245)
E2F Family Members Are Differentially Regulated by Reversible Acetylation* (2000) (234)
Induction of S-phase entry by E2F transcription factors depends on their nuclear localization (1997) (228)
The histone methyltransferase SET8 is required for S-phase progression (2007) (225)
Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome. (2014) (225)
The role of p53 and pRB in apoptosis and cancer. (2002) (224)
Nucleophosmin Is Required for DNA Integrity and p19Arf Protein Stability (2005) (217)
E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription (1998) (216)
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation (2013) (215)
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. (2009) (212)
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (2015) (210)
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death (2001) (207)
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A‐ARF locus (2007) (200)
Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary Gland (2005) (198)
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. (2010) (193)
A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation (2010) (191)
The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein (1998) (188)
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2 (2016) (187)
Jarid1b targets genes regulating development and is involved in neural differentiation (2011) (187)
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription (2005) (179)
Inhibition of demethylases by GSK-J1/J4 (2014) (178)
Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint (2001) (171)
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation (2013) (170)
Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (1993) (168)
The retinoblastoma protein as a transcriptional repressor. (1993) (166)
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes (1993) (162)
The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence (2015) (154)
Human Geminin promotes pre‐RC formation and DNA replication by stabilizing CDT1 in mitosis (2004) (145)
Epigenetic control of embryonic stem cell fate (2010) (143)
Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors. (1992) (140)
Quantitative Mass Spectrometry of Histones H3.2 and H3.3 in Suz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36* (2010) (139)
E2F-1-Induced p53-independent apoptosis in transgenic mice (1998) (139)
Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. (1997) (138)
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS (2014) (134)
p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression (1997) (133)
The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma (2011) (132)
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint (2009) (131)
Identification of Target Genes of the p16INK4A-pRB-E2F Pathway* (2003) (129)
E2F1 is crucial for E2F‐dependent apoptosis (2005) (128)
Cell Cycle-Regulated Expression of MammalianCDC6 Is Dependent on E2F (1998) (125)
Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus (2008) (125)
A Novel Repressive E2F6 Complex Containing the Polycomb Group Protein, EPC1, That Interacts with EZH2 in a Proliferation-specific Manner* (2005) (124)
The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors (2011) (124)
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2 (2018) (123)
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation (2011) (123)
Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer. (2016) (120)
Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1 (1993) (119)
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma (2013) (118)
Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells (2011) (118)
The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3 (2013) (113)
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. (2013) (104)
Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression (2016) (103)
A model for transmission of the H3K27me3 epigenetic mark (2008) (98)
Polycomb Group Proteins in Cell Cycle Progression and Cancer (2004) (97)
Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation. (2013) (97)
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. (1995) (91)
Inhibitors of histone demethylases. (2011) (90)
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry (2002) (88)
Utx Is Required for Proper Induction of Ectoderm and Mesoderm during Differentiation of Embryonic Stem Cells (2013) (87)
Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells. (2012) (87)
Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy (2013) (80)
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development (2016) (78)
Middle‐down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post‐translational modifications in histones (2014) (78)
Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes (2012) (77)
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication (2014) (76)
Molecular mechanisms in gliomagenesis. (2005) (76)
Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity. (2019) (76)
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia (2019) (75)
A role for the transcription factor HEY1 in glioblastoma (2008) (74)
Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines. (1991) (73)
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. (2013) (73)
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation (2018) (72)
The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner (2014) (71)
shRNA screening identifies JMJD1C as being required for leukemia maintenance. (2014) (70)
Oncohistones: drivers of pediatric cancers (2017) (69)
Reduced hepatic tumor incidence in cyclin G1‐deficient mice (2003) (69)
DNMT3AR882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice (2016) (66)
Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS. (2013) (65)
DcE2F, a Functional Plant E2F-like Transcriptional Activator from Daucus carota * (2000) (63)
Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein (1994) (63)
Quantification of differential transcription factor activity and multiomics-based classification into activators and repressors: diffTF (2018) (62)
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4‐pyridine‐dicarboxylic acid as an in vitro and in cell inhibitor (2012) (62)
Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro. (1995) (62)
E2F–HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer (2006) (62)
Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells (2016) (62)
MMSET is highly expressed and associated with aggressiveness in neuroblastoma. (2011) (61)
The Polycomb Repressive Complex 2 Is a Potential Target of SUMO Modifications (2008) (60)
NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression (2003) (60)
The Demethylase JMJD2C Localizes to H3K4me3-Positive Transcription Start Sites and Is Dispensable for Embryonic Development (2014) (60)
Cell Cycle-Regulated Expression of Mammalian CDC6 Is Dependent on E2F (1998) (58)
ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells (2016) (58)
RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo (2015) (56)
Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation* (2016) (56)
Erratum: Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures (1998) (55)
Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. (2015) (54)
Functional Screening Identifies miRNAs Influencing Apoptosis and Proliferation in Colorectal Cancer (2014) (54)
E2F-Rb Complexes Assemble and Inhibit cdc25A Transcription in Cervical Carcinoma Cells following Repression of Human Papillomavirus Oncogene Expression (2000) (54)
TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells (2018) (53)
Nucleocytoplasmic shuttling of transcription factors (2000) (53)
Hypermethylated in Cancer 1 (HIC1) Recruits Polycomb Repressive Complex 2 (PRC2) to a Subset of Its Target Genes through Interaction with Human Polycomb-like (hPCL) Proteins* (2012) (48)
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation (2015) (48)
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes (2020) (46)
An Inverted Repeat Motif Stabilizes Binding of E2F and Enhances Transcription of the Dihydrofolate Reductase Gene (*) (1995) (46)
Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein. (1999) (45)
The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. (2018) (44)
Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins (1994) (43)
Loss of MYC Confers Resistance to Doxorubicin-induced Apoptosis by Preventing the Activation of Multiple Serine Protease- and Caspase-mediated Pathways* (2004) (42)
Regulation of stem cell differentiation by histone methyltransferases and demethylases. (2008) (41)
Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS (2005) (40)
The biological activity of the human epidermal growth factor receptor is positively regulated by its C-terminal tyrosines. (1991) (40)
Explorer TET 1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (2012) (39)
PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN. (2019) (38)
Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2 (2009) (38)
Supplemental Information Fbxl 10 / Kdm 2 b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H 2 A Ubiquitylation (2013) (38)
Identification of catechols as histone–lysine demethylase inhibitors (2012) (37)
TET2 Deficiency Inhibits Mesoderm and Hematopoietic Differentiation in Human Embryonic Stem Cells (2014) (37)
NEK11−Linking CHK1 and CDC25A in DNA damage checkpoint signaling (2010) (36)
Revolution in the Polycomb hierarchy (2014) (36)
The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice. (2015) (36)
Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells (2013) (35)
DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function (2008) (35)
H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans (2015) (35)
A Novel Zinc Finger Protein Zfp277 Mediates Transcriptional Repression of the Ink4a/Arf Locus through Polycomb Repressive Complex 1 (2010) (34)
Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals (2015) (34)
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication (2013) (33)
Human TFDP3, a Novel DP Protein, Inhibits DNA Binding and Transactivation by E2F* (2007) (32)
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. (2019) (31)
Profiling cancer. (2003) (30)
The Ubiquitin Ligase HectH 9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation (2017) (29)
Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5 (2015) (29)
PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells (2019) (29)
The regulation of APAF1 expression during development and tumourigenesis (2002) (28)
PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination (2020) (27)
Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals (2022) (27)
EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice (2017) (27)
E2F activates late-G1 events but cannot replace E1A in inducing S phase in terminally differentiated skeletal muscle cells (1999) (27)
A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2 (2019) (26)
BTK inhibitors synergise with 5‐FU to treat drug‐resistant TP53‐null colon cancers (2020) (26)
TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis (2021) (26)
Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development (2017) (25)
Human CDT1 Associates with CDC7 and Recruits CDC45 to Chromatin during S Phase* (2009) (25)
The Tumor Suppressor Gene Hypermethylated in Cancer 1 Is Transcriptionally Regulated by E2F1 (2009) (25)
The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells. (2019) (24)
Expression of the Transcription Factor HEY1 in Glioblastoma: A Preliminary Clinical Study (2010) (24)
E2F1-mediated transcriptional inhibition of the plasminogen activator inhibitor type 1 gene. (2001) (24)
Geminin: A Major DNA Replication Safeguard in Higher Eukaryotes (2004) (22)
Cell cycle – and cell growth – regulated proteolysis of mammalian CDC 6 is dependent on APC – CDH 1 (2000) (22)
A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB‐2. (1992) (22)
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary (2020) (22)
Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex. (2000) (22)
E2F-Dependent Induction of p14ARF During Cell Cycle Re-entry in Human T Cells (2007) (22)
Identification of Target Genes of the p 16 INK 4 A-pRB-E 2 F Pathway * (2003) (22)
APAF 1 is a key transcriptional target for p 53 in the regulation of neuronal cell death (2001) (21)
HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases (2018) (20)
Characterization of E 2 F 8 , a novel E 2 F-like cell-cycle regulated repressor of E 2 F-activated transcription (2005) (19)
Isolation and characterization of DUSP11, a novel p53 target gene (2009) (19)
SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance (2015) (19)
A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence (2014) (18)
MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells (2021) (17)
erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling. (1992) (17)
OVCA1: emerging as a bona fide tumor suppressor. (2004) (16)
Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. (2019) (16)
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. (2021) (15)
Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression (2022) (15)
Cancer Therapy : Preclinical Inhibition of GSK 3 B Bypass Drug Resistance of p 53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy (2013) (14)
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. (2021) (13)
MYELOID NEOPLASIA shRNA screening identi fi es JMJD 1 C as being required for leukemia maintenance (2014) (13)
The p53 Tumour Suppressor Protein (2000) (13)
Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues. (1991) (13)
Genome-wide profiling identifies a DNA methylation signature that associates with TET 2 mutations in diffuse large B-cell lymphoma (2013) (13)
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation (2013) (12)
SET 8 is degraded via PCNA-coupled CRL 4 ( CDT 2 ) ubiquitylation in S phase and after UV irradiation (2011) (12)
Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity (2018) (12)
The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity (2021) (11)
Transcriptional inhibition by the retinoblastoma protein. (1993) (11)
Mutant FOXL2C134W Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors (2020) (10)
The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis (2019) (10)
A new role for the polycomb group protein Ezh1 in promoting transcription. (2012) (9)
The Role of Chromatin-Associated Proteins in Cancer (2017) (9)
Tumor suppressors: from genes to function and possible therapies. (1998) (9)
Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia. (2021) (8)
PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands (2021) (7)
Naturally death-resistant precursor cells revealed as the origin of retinoblastoma. (2004) (7)
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release (2023) (7)
Fbxl 10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg 2 (2015) (6)
Human TFDP 3 , a novel DP protein , inhibits DNA binding and transactivation by E 2 F (2006) (6)
Jmjd 2 / Kdm 4 demethylases are required for expression of Il 3 ra and survival of acute myeloid leukemia cells (2016) (6)
The histone demethylase Jarid1b mediates angiotensin II‐induced endothelial dysfunction by controlling the 3′UTR of soluble epoxide hydrolase (2019) (6)
cells reveals distinct, dynamic post-translational modifications at K27 and K36. (2010) (5)
TET1: an epigenetic guardian of lymphomagenesis (2015) (5)
The Tumor Suppressor Gene Hypermethylated in Cancer 1 Is Transcriptionally Regulated by E 2 F 1 (2009) (4)
Regional tumour glutamine supply affects chromatin and cell identity (2016) (4)
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway (2022) (3)
Positive Transcription Start Sites and Is Dispensable for (2014) (3)
p65BTK targeting restores the apoptotic response to chemotherapy of p53-null drug-resistant colon cancer cells (2016) (3)
CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency. (2022) (3)
Cell cycle, differentiation and disease. (2013) (3)
Chromatin regulated interchange between PRC2-Ezh2 and PRC2-Ezh1 complexes controls Myogenin activation in skeletal muscle cells. (2011) (2)
Is Dependent on E 2 F CDC 6 Mammalian Cell Cycle-Regulated Expression of (1998) (2)
BMP2/SMAD pathway activation in JAK2/p53-mutant Megakaryocyte/Erythroid Progenitors Promotes Leukemic Transformation. (2022) (2)
cellular differentiation and disease Erasing the methyl mark : histone demethylases at the center of (2008) (2)
Tumor and Stem Cell Biology Histone Acetyltransferase PCAF Is Required for Hedgehog – Gli-Dependent Transcription and Cancer Cell Proliferation (2013) (1)
A kinase-directed RNAi screen identifies GSK-3b/a as a target to overcome drug resistance of p53-null colon cancer cells (2010) (1)
ChIP-Sequencing of TET Proteins. (2021) (1)
Erratum: A model for transmission of the H3K27me3 epigenetic mark (Nature Cell Biology (2008) vol. 10 (1291-1300)) (2008) (1)
Abstract B113: GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis. (2013) (1)
12 Histone Lysine Demethylases and Cancer (2008) (1)
P11.36 Ribosome hydroxylase Mina53 is required for Glioblastoma and is involved in regulation of translation rateand fidelity by regulating ribosomal biogenesis (2019) (1)
a new heterochromatic mark in Caenorhabditis elegans (2015) (1)
Explorer A Functional Link between the Histone Demethylase PHF 8 and the Transcription Factor ZNF 711 in X-Linked Mental Retardation (2017) (1)
Abstract LB-79: PRC2 loss amplifies Ras-driven transcription and sensitizes cancers to bromodomain inhibitor-based combination therapies (2014) (1)
The Lysine Demethylase KDM 5 B Regulates Islet Function and Glucose Homeostasis (2019) (1)
TET2 mutations in Diffuse Large B-Cell Lymphoma: The Role of TET2 in the Regulation of Methylation Patterns at TET2 Target Genes (2011) (1)
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas (2017) (1)
Generation of locus-specific degradable tag knock-ins in mouse and human cell lines (2021) (1)
Bricks and mortar. Building Copenhagen's BioCentre. (2004) (0)
HIC1 is a new E2F1 transcriptional target involved in cell death (2007) (0)
Loss of PRC2 Amplifies Ras-driven Transcription and Sensitizes MPNSTs to Bromodomain Inhibitor-based Combination Therapies (2014) (0)
Epigenetic Control and the Development of Cancer (2007) (0)
[Basic stem cell biology and cancer]. (2010) (0)
Syddansk Universitet Systems Level Analysis of Histone H 3 Post-translational Modifications ( PTMs ) Reveals Features of PTM Crosstalk in Chromatin Regulation (2016) (0)
Edinburgh Research Explorer The histone lysine demethylase JMJD3/KDM6B Is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner (2017) (0)
roles in cell fate transitions Genome-wide mapping of Polycomb target genes unravels their Material (2006) (0)
325 The role histone methyl transferases and demethylases in stem cell differentiation and cancer (2010) (0)
A single aminoacidsubstitution issufficient tomodify themitogenic properties oftheepidermal growthfactor receptor toresemble thatofgpl85erbB-2 (1992) (0)
Quantifying Histone Variants and Modifications for Senescence by Label-free LC-MS (2008) (0)
4: Epigenetic targets in cancer (2014) (0)
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2 (2018) (0)
Quantification of Histone Modifications Upon Suz12 Deletion in Embryonic Stem Cells by High Mass Accuracy LTQ-CID/ETD-Orbitrap Mass Spectrometry (2009) (0)
New EMBO Member ’ s Review The E 2 F family : specific functions and overlapping interests (2013) (0)
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis. Radzisheuskaya et al. (2021) (0)
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation (2018) (0)
OPPOSING FUNCTIONS FOR POLYCOMB CBX FAMILY PROTEINS IN HSC REGULATION (2011) (0)
Universitet The Lysine Demethylase KDM 5 B Regulates Islet Function and Glucose Homeostasis (2019) (0)
Correction for Danovi et al., “Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity” (2019) (0)
The PRC2 component JARID2 is dispensable for hematopoietic stem cells, but critical for maintenance of leukemic stem cells (2016) (0)
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes (2020) (0)
Loss Of Tet2 Collaborates With AML1-ETO In Inducing Leukemogenesis (2013) (0)
University of Groningen Jmjd 2 / Kdm 4 demethylases are required for expression of Il 3 ra and survival of acute myeloid leukemia cells (2017) (0)
An integrated approach to study chromatin and transcriptional dynamics throughout the cell cycle without pharmacological inhibition (2022) (0)
Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity (2018) (0)
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia (2019) (0)
compaRe, an ultra-fast and robust suite for multiparametric screening, identifies phenotypic drug responses in acute myeloid leukemia (2021) (0)
Transcriptional control of cell growth: The E2F gene family (1996) (0)
The methylation inhibitor 3DZNep promotes HDR pathway choice during CRISPR-Cas9 genome editing (2022) (0)
PR-DUB safeguards Polycomb repression through H2AK119ub1 restriction. (2023) (0)
Regulation of cell proliferation by the E2F transcription factors (1999) (0)
POLYCOMB CBX ORTHOLOGS MEDIATE THE BALANCE BETWEEN HEMATOPOIETIC STEM CELL SELF-RENEWAL AND DIFFERENTIATION (2012) (0)
Abstract IA10: Mechanisms regulating polycomb group proteins to target genes (2013) (0)
Abstract A19: The histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and proliferation (2013) (0)
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes (2023) (0)
61 The role of the Jumonji 2 (JMJD2) Histone Demethylases in Cell Proliferation and Cancer (2008) (0)
DevelopmentIs Dispensable for Embryonic H3K4me3-Positive Transcription Start Sites The Demethylase JMJD2C Localizes to (2014) (0)
26 Critical role of NEK11 kinase in the IR-induced G2 checkpoint (2008) (0)
Contents: Proteomics 19'15. (2015) (0)
Abstract PR12: CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and Polycomb gene repression (2013) (0)
Catching active enhancers via H2B N-terminal acetylation (2023) (0)
Bricks & Mortar (2004) (0)
Publisher Correction: H3K4me3 regulates RNA polymerase II promoter-proximal pause-release (2023) (0)
Correction: A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence (2022) (0)

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