Krzysztof Palczewski
#89,931
Most Influential Person Now
Researcher
Krzysztof Palczewski's AcademicInfluence.com Rankings
Krzysztof Palczewskimedical Degrees
Medical
#930
World Rank
#1198
Historical Rank
Pharmacology
#61
World Rank
#82
Historical Rank
Krzysztof Palczewskibiology Degrees
Biology
#4066
World Rank
#6119
Historical Rank
Cell Biology
#96
World Rank
#101
Historical Rank
Molecular Biology
#290
World Rank
#295
Historical Rank
Biochemistry
#410
World Rank
#488
Historical Rank
Download Badge
Medical Biology
Krzysztof Palczewski's Degrees
- PhD Biochemistry University of Gdańsk
- Masters Biochemistry University of Gdańsk
Why Is Krzysztof Palczewski Influential?
(Suggest an Edit or Addition)Krzysztof Palczewski's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Crystal structure of rhodopsin: a G-protein-coupled receptor. (2000) (4692)
- Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor (2002) (1108)
- Atomic-force microscopy: Rhodopsin dimers in native disc membranes (2003) (767)
- G protein-coupled receptor rhodopsin. (2006) (672)
- Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes* (2003) (597)
- Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). (2001) (585)
- Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. (2005) (461)
- Crystal structure of a photoactivated deprotonated intermediate of rhodopsin (2006) (441)
- Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. (2007) (395)
- Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. (2003) (372)
- Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein (1994) (362)
- Activation of rhodopsin: new insights from structural and biochemical studies. (2001) (360)
- Confronting Complexity: the Interlink of Phototransduction and Retinoid Metabolism in the Vertebrate Retina (2001) (353)
- Phagocytosis of retinal rod and cone photoreceptors. (2010) (342)
- Lecithin-retinol Acyltransferase Is Essential for Accumulation of All-trans-Retinyl Esters in the Eye and in the Liver* (2004) (342)
- Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation (2003) (320)
- International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers (2007) (299)
- Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:Retinol Acyltransferase (LRAT)* (2005) (282)
- Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function (2004) (280)
- Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina (1996) (279)
- Mechanism of rhodopsin kinase activation. (1991) (271)
- A mitochondrial enzyme degrades carotenoids and protects against oxidative stress (2011) (270)
- Efficient Coupling of Transducin to Monomeric Rhodopsin in a Phospholipid Bilayer* (2008) (269)
- Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success (2005) (267)
- Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. (2000) (263)
- Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. (2006) (262)
- Chemistry of the Retinoid (Visual) Cycle (2013) (260)
- Retinopathy in Mice Induced by Disrupted All-trans-retinal Clearance* (2008) (259)
- Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina (2013) (257)
- Five Members of a Novel Ca2+-binding Protein (CABP) Subfamily with Similarity to Calmodulin* (2000) (256)
- Chemistry and Biology of Vision* (2011) (246)
- A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy (1991) (246)
- Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. (1994) (241)
- Oligomerization of G protein-coupled receptors: past, present, and future. (2004) (239)
- The G protein‐coupled receptor rhodopsin in the native membrane (2004) (233)
- Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors (2009) (230)
- G protein-coupled receptor rhodopsin: a prospectus. (2003) (223)
- Involvement of All-trans-retinal in Acute Light-induced Retinopathy of Mice* (2009) (222)
- Anti-rhodopsin monoclonal antibodies of defined specificity: Characterization and application (1991) (218)
- The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery (2011) (213)
- Probing Mechanisms of Photoreceptor Degeneration in a New Mouse Model of the Common Form of Autosomal Dominant Retinitis Pigmentosa due to P23H Opsin Mutations*♦ (2011) (211)
- Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca2+ release channels (2002) (203)
- Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. (1991) (203)
- Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography (2007) (200)
- Sequential phosphorylation of rhodopsin at multiple sites. (1993) (196)
- Structure of cone photoreceptors (2009) (196)
- ISX is a retinoic acid‐sensitive gatekeeper that controls intestinal β,β‐carotene absorption and vitamin A production (2010) (195)
- Pharmacological Chaperone-mediated in Vivo Folding and Stabilization of the P23H-opsin Mutant Associated with Autosomal Dominant Retinitis Pigmentosa* (2003) (194)
- The role of arrestin and retinoids in the regeneration pathway of rhodopsin. (1992) (190)
- The effect of recoverin-like calcium-Binding proteins on the photoresponse of retinal rods (1993) (190)
- Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina* 210 (2002) (187)
- Structural waters define a functional channel mediating activation of the GPCR, rhodopsin (2009) (181)
- Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye (2004) (180)
- X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. (2000) (178)
- Differential modulation of Cav2.1 channels by calmodulin and Ca2+-binding protein 1 (2002) (177)
- Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway (2014) (177)
- Molecular Characterization of a Novel Short-chain Dehydrogenase/Reductase That Reduces All-trans-retinal* (1998) (176)
- Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. (1994) (175)
- G-protein-coupled receptor kinases. (1991) (172)
- RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. (2008) (171)
- A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. (2004) (171)
- ABCA4 disease progression and a proposed strategy for gene therapy. (2009) (171)
- Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration* (2011) (169)
- Rhodopsin Phosphorylation and Dephosphorylation in Vivo(*) (1995) (168)
- High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. (1998) (163)
- The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. (2010) (161)
- Phototransduction: crystal clear. (2003) (158)
- Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. (1998) (157)
- Guanylyl Cyclase Activating Protein (1995) (156)
- Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. (2002) (155)
- Recovery of Visual Functions in a Mouse Model of Leber Congenital Amaurosis* (2002) (154)
- Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. (1999) (153)
- The Function of Guanylate Cyclase 1 and Guanylate Cyclase 2 in Rod and Cone Photoreceptors* (2007) (152)
- Key enzymes of the retinoid (visual) cycle in vertebrate retina. (2012) (151)
- The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. (1991) (150)
- Ca2+‐binding proteins in the retina: Structure, function, and the etiology of human visual diseases (2000) (149)
- Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal* (2013) (146)
- Three-dimensional Structure of Guanylyl Cyclase Activating Protein-2, a Calcium-sensitive Modulator of Photoreceptor Guanylyl Cyclases* (1999) (144)
- Cloning and characterization of a human β, β-carotene-15, 15'-dioxygenase that is highly expressed in the retinal pigment epithelium (2001) (143)
- Role of Photoreceptor-specific Retinol Dehydrogenase in the Retinoid Cycle in Vivo* (2005) (143)
- Rhodopsin phosphorylation: 30 years later (2003) (143)
- Human cone photoreceptor dependence on RPE65 isomerase (2007) (142)
- Rhodopsin Signaling and Organization in Heterozygote Rhodopsin Knockout Mice* (2004) (141)
- Crystal structure of native RPE65, the retinoid isomerase of the visual cycle (2009) (140)
- Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection* (2013) (140)
- GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. (1998) (139)
- The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction (1992) (138)
- Functional and Structural Characterization of Rhodopsin Oligomers* (2006) (138)
- Molecular Characterization of a Third Member of the Guanylyl Cyclase-activating Protein Subfamily* (1999) (136)
- Two Carotenoid Oxygenases Contribute to Mammalian Provitamin A Metabolism* ♦ (2013) (133)
- A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. (1998) (131)
- Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. (2008) (131)
- G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. (2001) (130)
- Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy. (1993) (130)
- Disruption of the 11-cis-Retinol Dehydrogenase Gene Leads to Accumulation of cis-Retinols andcis-Retinyl Esters (2000) (130)
- β,β-Carotene Decreases Peroxisome Proliferator Receptor γ Activity and Reduces Lipid Storage Capacity of Adipocytes in a β,β-Carotene Oxygenase 1-dependent Manner* (2010) (129)
- Preferential Release of 11-cis-retinol from Retinal Pigment Epithelial Cells in the Presence of Cellular Retinaldehyde-binding Protein* (1999) (128)
- Primary amines protect against retinal degeneration in mouse models of retinopathies (2011) (128)
- The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. (2003) (128)
- Purification and characterization of rhodopsin kinase. (1988) (127)
- Pharmacological and rAAV Gene Therapy Rescue of Visual Functions in a Blind Mouse Model of Leber Congenital Amaurosis (2005) (126)
- Reduction of all-trans-retinal limits regeneration of visual pigment in mice (1998) (126)
- Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin. (1993) (126)
- Functional Characterization of Rhodopsin Monomers and Dimers in Detergents* (2004) (126)
- Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. (2005) (125)
- Regulation of rhodopsin dephosphorylation by arrestin. (1989) (122)
- Sponge Transgenic Mouse Model Reveals Important Roles for the MicroRNA-183 (miR-183)/96/182 Cluster in Postmitotic Photoreceptors of the Retina* (2011) (120)
- Structural and Enzymatic Aspects of Rhodopsin Phosphorylation (*) (1996) (118)
- Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1* (2010) (117)
- The Molecular Basis of Retinoid Absorption (2008) (117)
- Crystal structure of rhodopsin: implications for vision and beyond. (2001) (117)
- Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. (2005) (115)
- Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. (1991) (115)
- Rhodopsin kinase: substrate specificity and factors that influence activity. (1988) (114)
- GTP-binding-protein-coupled receptor kinases--two mechanistic models. (1997) (113)
- Retinoids for treatment of retinal diseases. (2010) (111)
- Redundant and unique roles of retinol dehydrogenases in the mouse retina (2007) (110)
- Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. (2007) (110)
- The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. (2010) (109)
- Ligand Channeling within a G-protein-coupled Receptor (2003) (109)
- Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins (2022) (109)
- Retinol Dehydrogenase (RDH12) Protects Photoreceptors from Light-induced Degeneration in Mice* (2006) (107)
- Heterogeneous N-acylation is a tissue- and species-specific posttranslational modification. (1994) (104)
- Structural basis of carotenoid cleavage: from bacteria to mammals. (2013) (104)
- Guanylate cyclase-activating proteins: structure, function, and diversity. (2004) (104)
- Regulation of rhodopsin kinase by autophosphorylation. (1991) (102)
- Mechanisms of Opsin Activation* (1996) (102)
- Characterization of retinal guanylate cyclase‐activating protein 3 (GCAP3) from zebrafish to man (2002) (102)
- Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. (2004) (102)
- Trafficking of Membrane-Associated Proteins to Cone Photoreceptor Outer Segments Requires the Chromophore 11-cis-Retinal (2008) (101)
- GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice (2002) (101)
- Calcium modulation of bovine photoreceptor guanylate cyclase. (1996) (101)
- Visual Rhodopsin Sees the Light: Structure and Mechanism of G Protein Signaling* (2007) (101)
- Delayed Dark Adaptation in 11-cis-Retinol Dehydrogenase-deficient Mice (2005) (100)
- Rhodopsin self-associates in asolectin liposomes. (2006) (100)
- Oligomeric forms of G protein-coupled receptors (GPCRs). (2010) (99)
- Diversity of Guanylate Cyclase-Activating Proteins (GCAPs) in Teleost Fish: Characterization of Three Novel GCAPs (GCAP4, GCAP5, GCAP7) from Zebrafish (Danio rerio) and Prediction of Eight GCAPs (GCAP1-8) in Pufferfish (Fugu rubripes) (2004) (98)
- Vertebrate Membrane Proteins: Structure, Function, and Insights from Biophysical Approaches (2008) (97)
- Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. (2002) (97)
- Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man (2000) (97)
- A splice variant of arrestin. Molecular cloning and localization in bovine retina. (1994) (96)
- Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins, Adrenergic and Adenosine Receptors (2009) (95)
- Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation* (2008) (95)
- Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration (2015) (94)
- Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy (2010) (94)
- G protein-coupled receptors--recent advances. (2012) (93)
- Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. (2004) (93)
- Signaling States of Rhodopsin (2003) (92)
- Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. (2002) (92)
- Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. (2000) (89)
- Metabolic Basis of Visual Cycle Inhibition by Retinoid and Nonretinoid Compounds in the Vertebrate Retina* (2008) (89)
- The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. (2000) (88)
- STRA6 is critical for cellular vitamin A uptake and homeostasis. (2014) (87)
- Delivery of retinoid-based therapies to target tissues. (2007) (87)
- P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. (2014) (87)
- Control of rhodopsin multiple phosphorylation. (1994) (86)
- Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin. (1991) (86)
- Structure and functions of arrestins (1994) (86)
- Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. (2005) (85)
- Activation and inactivation steps in the visual transduction pathway (1997) (85)
- Molecular Forms of Human Rhodopsin Kinase (GRK1)* (1998) (84)
- Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase* (2004) (84)
- Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. (2009) (84)
- Lentiviral Expression of Retinal Guanylate Cyclase-1 (RetGC1) Restores Vision in an Avian Model of Childhood Blindness (2006) (84)
- GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base (2010) (82)
- Defective photoreceptor phagocytosis in a mouse model of enhanced S‐cone syndrome causes progressive retinal degeneration (2011) (82)
- Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. (2011) (82)
- The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes (2004) (81)
- Effects of Potent Inhibitors of the Retinoid Cycle on Visual Function and Photoreceptor Protection from Light Damage in Mice (2006) (80)
- Lecithin:Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein* (2012) (80)
- Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. (2009) (79)
- Structural Analysis of Mg2+ and Ca2+ Binding to CaBP1, a Neuron-specific Regulator of Calcium Channels* (2005) (79)
- Retinyl Ester Formation by Lecithin:Retinol Acyltransferase Is a Key Regulator of Retinoid Homeostasis in Mouse Embryogenesis* (2008) (78)
- Retinal Pigmented Epithelial Cells Obtained from Human Induced Pluripotent Stem Cells Possess Functional Visual Cycle Enzymes in Vitro and in Vivo* (2013) (78)
- Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye (2014) (77)
- Retinoids and Retinal Diseases. (2016) (77)
- Evaluation of the role of the retinal G protein‐coupled receptor (RGR) in the vertebrate retina in vivo (2003) (77)
- Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1. (1997) (77)
- Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. (1994) (77)
- The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. (1989) (77)
- Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. (1998) (77)
- Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. (2009) (77)
- Detecting molecular interactions that stabilize native bovine rhodopsin. (2006) (75)
- Retinyl Ester Storage Particles (Retinosomes) from the Retinal Pigmented Epithelium Resemble Lipid Droplets in Other Tissues* (2011) (75)
- Human infrared vision is triggered by two-photon chromophore isomerization (2014) (75)
- Characterization of a truncated form of arrestin isolated from bovine rod outer segments (1994) (74)
- The retinoid cycle and retina disease (2003) (73)
- A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration. (2004) (73)
- Structure, alternative splicing, and expression of the human RGS9 gene. (1999) (72)
- Localization of guanylate cyclase-activating protein 2 in mammalian retinas. (1997) (71)
- Noninvasive multi–photon fluorescence microscopy resolves retinol and retinal–condensation products in mouse eyes (2010) (69)
- Asymmetry of the rhodopsin dimer in complex with transducin (2013) (69)
- Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. (2012) (67)
- Inner retinal photoreception independent of the visual retinoid cycle (2006) (67)
- Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface* (2015) (66)
- Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. (2006) (66)
- Synthetic phosphopeptides are substrates for casein kinase II (1990) (66)
- Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. (2015) (66)
- Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. (2011) (65)
- Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. (1989) (65)
- Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. (2013) (65)
- Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization (2003) (64)
- Calcium-Sensitive Particulate Guanylyl Cyclase as a Modulator of cAMP in Olfactory Receptor Neurons (1998) (63)
- Vitamin A Deficiency Results in Meiotic Failure and Accumulation of Undifferentiated Spermatogonia in Prepubertal Mouse Testis1 (2011) (63)
- Binding of inositol phosphates to arrestin (1991) (62)
- Stabilizing Effect of Zn2+ in Native Bovine Rhodopsin* (2007) (62)
- Identification of the autophosphorylation sites in rhodopsin kinase. (1992) (61)
- Catalytic mechanism of a retinoid isomerase essential for vertebrate vision (2015) (61)
- Importance of Membrane Structural Integrity for RPE65 Retinoid Isomerization Activity* (2010) (61)
- Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins* (2012) (60)
- A Naturally Occurring Mutation of the Opsin Gene (T4R) in Dogs Affects Glycosylation and Stability of the G Protein-coupled Receptor* (2004) (60)
- Membrane-binding and enzymatic properties of RPE65 (2010) (60)
- Gene transfer mediated by recombinant baculovirus into mouse eye. (2001) (59)
- Characterization of a Dehydrogenase Activity Responsible for Oxidation of 11-cis-Retinol in the Retinal Pigment Epithelium of Mice with a Disrupted RDH5 Gene (2001) (59)
- A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). (2005) (59)
- Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor (2018) (59)
- In vivo two-photon imaging of the mouse retina. (2012) (58)
- Diversifying the repertoire of G protein-coupled receptors through oligomerization. (2005) (58)
- Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing (2020) (58)
- Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. (2011) (57)
- Toll-like Receptor 3 Is Required for Development of Retinopathy Caused by Impaired All-trans-retinal Clearance in Mice* (2011) (57)
- Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes (2017) (57)
- Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye (2016) (57)
- Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis (2012) (57)
- Pan1b (17βHSD11)-enzymatic activity and distribution in the lung (2001) (56)
- o-Phthalaldehyde, a fluorescence probe of aldolase active site. (1983) (56)
- Time-Resolved Fluorescence Spectroscopy Measures Clustering and Mobility of a G Protein-Coupled Receptor Opsin in Live Cell Membranes (2014) (55)
- Short-chain dehydrogenases/reductases in retina. (2000) (55)
- Palmitoylation stabilizes unliganded rod opsin (2010) (54)
- Clarin-1, Encoded by the Usher Syndrome III Causative Gene, Forms a Membranous Microdomain (2009) (54)
- Beta-arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients. (1993) (54)
- Lecithin:Retinol Acyltransferase Is Responsible for Amidation of Retinylamine, a Potent Inhibitor of the Retinoid Cycle* (2005) (54)
- Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes (2016) (54)
- Molecular pharmacodynamics of emixustat in protection against retinal degeneration. (2015) (54)
- Evidence for RPE65‐independent vision in the cone‐dominated zebrafish retina (2007) (54)
- Nonvisual Photoreception in the Chick Iris (2004) (53)
- Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. (2011) (53)
- Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: Biochemical and clinical evaluations (2007) (52)
- Role of Bulk Water in Hydrolysis of the Rhodopsin Chromophore* (2011) (52)
- Topology and Membrane Association of Lecithin: Retinol Acyltransferase* (2007) (52)
- The physiological impact of microRNA gene regulation in the retina (2012) (52)
- Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1. (1999) (52)
- Molecular cloning and localization of rhodopsin kinase in the mammalian pineal (1997) (51)
- Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. (2006) (51)
- Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. (2009) (51)
- Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. (2000) (50)
- Conformational Changes in Guanylyl Cyclase-activating Protein 1 (GCAP1) and Its Tryptophan Mutants as a Function of Calcium Concentration* (1999) (50)
- Structural Insights into Ca2+-dependent Regulation of Inositol 1,4,5-Trisphosphate Receptors by CaBP1* (2009) (50)
- DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice (2014) (50)
- Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. (2013) (49)
- Melanopsin Is Highly Resistant to Light and Chemical Bleaching in Vivo* (2012) (49)
- β-Arrestin-dependent Desensitization of Luteinizing Hormone/Choriogonadotropin Receptor Is Prevented by a Synthetic Peptide Corresponding to the Third Intracellular Loop of the Receptor* (1999) (49)
- The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. (2006) (49)
- Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid* (2005) (49)
- Ca2+‐dependent Regulation of Phototransduction † (2008) (49)
- Chemokine receptors and other G protein-coupled receptors (2009) (48)
- Nucleotide inhibitors and activators of retinal guanylyl cyclase. (1994) (48)
- A critical role of CaBP4 in the cone synapse. (2005) (48)
- Increased adiposity in the retinol saturase‐knockout mouse (2010) (48)
- Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base (2007) (48)
- Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. (2009) (47)
- Human aging and disease: Lessons from age-related macular degeneration (2018) (47)
- Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase. (1994) (47)
- Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function. (2008) (47)
- Isomerization of 11-cis-Retinoids to All-trans-retinoids in Vitro and in Vivo * (2001) (47)
- Cryo-EM structure of the native rhodopsin dimer in nanodiscs (2019) (46)
- Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. (1998) (46)
- Rhodopsin Kinase Autophosphorylation (1995) (46)
- Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice (2014) (45)
- Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness (2017) (45)
- The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors. (2015) (45)
- Designing Safer Analgesics via μ-Opioid Receptor Pathways. (2017) (45)
- Crystal packing analysis of Rhodopsin crystals. (2007) (44)
- Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. (2010) (44)
- The rhodopsin-transducin complex houses two distinct rhodopsin molecules. (2013) (44)
- LRAT-specific domain facilitates Vitamin A metabolism by domain swapping in HRASLS (2014) (44)
- Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability (2015) (44)
- Inherent Instability of the Retinitis Pigmentosa P23H Mutant Opsin* (2014) (44)
- Inflammatory priming predisposes mice to age-related retinal degeneration. (2012) (44)
- Advances in understanding the molecular basis of the first steps in color vision (2015) (43)
- Mechanism of Rhodopsin Activation as Examined with Ring-constrained Retinal Analogs and the Crystal Structure of the Ground State Protein* (2001) (43)
- Photoreceptor phagocytosis is mediated by phosphoinositide signaling (2013) (43)
- Structural and Functional Analysis of the Native Peripherin-ROM1 Complex Isolated from Photoreceptor Cells* (2013) (42)
- Responses of the phototransduction cascade to dim light. (1996) (42)
- Comparative Analysis of GPCR Crystal Structures † (2009) (42)
- A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. (1999) (42)
- Activation of Retinoic Acid Receptors by Dihydroretinoids (2009) (42)
- Retinylamine Benefits Early Diabetic Retinopathy in Mice* (2013) (42)
- The impact of microRNA gene regulation on the survival and function of mature cell types in the eye (2016) (42)
- From atomic structures to neuronal functions of g protein-coupled receptors. (2013) (41)
- Chemistry and biology of the initial steps in vision: the Friedenwald lecture. (2014) (41)
- The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). (1997) (41)
- A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration (2018) (41)
- QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. (2013) (41)
- Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. (2006) (41)
- A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness (2018) (41)
- A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy (2008) (40)
- The Molecular Mechanism of P2Y1 Receptor Activation (2016) (40)
- PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation (2020) (40)
- A small molecule mitigates hearing loss in a mouse model of Usher syndrome III (2016) (40)
- Phosphorylation of RGS9-1 by an Endogenous Protein Kinase in Rod Outer Segments* (2001) (40)
- Evolutionarily conserved long intergenic non-coding RNAs in the eye. (2013) (40)
- Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by alpha-toxin. (1998) (40)
- Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans (2010) (40)
- Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. (2009) (39)
- Complexes between photoactivated rhodopsin and transducin: progress and questions. (2010) (39)
- Utilization of Dioxygen by Carotenoid Cleavage Oxygenases*♦ (2015) (39)
- Calcium-sensitive Regions of GCAP1 as Observed by Chemical Modifications, Fluorescence, and EPR Spectroscopies* (2001) (39)
- Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. (2004) (39)
- Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. (2000) (39)
- Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. (2001) (38)
- Partial Agonism in a G Protein-coupled Receptor (2005) (38)
- Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy (2019) (37)
- Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light‐induced damage (2012) (37)
- Nucleoside inhibitors of rhodopsin kinase. (1990) (37)
- Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. (2006) (37)
- Rhodopsin: A Structural Primer for G‐Protein Coupled Receptors (2005) (37)
- Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. (1990) (37)
- Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. (2002) (37)
- Sequestration of Retinyl Esters Is Essential for Retinoid Signaling in the Zebrafish Embryo* (2007) (36)
- Ca2+-binding proteins in the retina: From discovery to etiology of human disease (2000) (36)
- Exploring a new ligand binding site of G protein-coupled receptors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01680a (2018) (36)
- Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration (2016) (36)
- Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. (2011) (35)
- Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. (2012) (35)
- Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. (2007) (35)
- Insights into Substrate Specificity and Metal Activation of Mammalian Tetrahedral Aspartyl Aminopeptidase* (2012) (35)
- Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. (2008) (35)
- Reliable Determination of Site-Specific In Vivo Protein N-Glycosylation Based on Collision-Induced MS/MS and Chromatographic Retention Time (2014) (34)
- Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. (2008) (34)
- Biochemical and Physiological Properties of Rhodopsin Regenerated with 11-cis-6-Ring- and 7-Ring-retinals* (2002) (33)
- In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones (2015) (33)
- Expression of GCAP 1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina (1996) (33)
- Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. (2016) (32)
- Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine. (2009) (32)
- Expression of functional G protein‐coupled receptors in photoreceptors of transgenic Xenopus laevis (2005) (32)
- Modulation of molecular interactions and function by rhodopsin palmitylation. (2009) (31)
- Dietary 9-cis-β,β-Carotene Fails to Rescue Vision in Mouse Models of Leber Congenital Amaurosis (2011) (31)
- A novel form of rhodopsin kinase from chicken retina and pineal gland 1 (1999) (31)
- Protein-Coupled Receptor Crystal Structure of Rhodopsin : A G (2008) (30)
- Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)* (2014) (30)
- Vaccination with recoverin, a cancer‐associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice (2002) (30)
- Identification of Protein Kinase C Isozymes Responsible for the Phosphorylation of Photoreceptor-specific RGS9-1 at Ser475 * (2003) (30)
- Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. (2001) (29)
- Dominant and recessive mutations in rhodopsin activate different cell death pathways. (2016) (29)
- Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium* (2015) (29)
- Light‐sensitive coupling of rhodopsin and melanopsin to Gi/o and Gq signal transduction in Caenorhabditis elegans (2012) (29)
- Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis (2017) (29)
- Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease (2018) (28)
- Photic generation of 11-cis-retinal in bovine retinal pigment epithelium (2019) (28)
- A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. (2012) (28)
- Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. (2013) (28)
- Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin (2009) (28)
- Shedding new light on the generation of the visual chromophore (2020) (28)
- Eyes on systems pharmacology. (2016) (28)
- Endogenous fluorophores enable two-photon imaging of the primate eye. (2014) (28)
- Imaging of protein crystals with two-photon microscopy. (2012) (27)
- Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina* (2008) (27)
- Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. (2013) (27)
- Structural characterization of the rod cGMP phosphodiesterase 6. (2010) (27)
- Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration (2016) (27)
- Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. (2015) (27)
- Purification of Arrestin from Bovine Retinas (1993) (26)
- Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. (2020) (26)
- Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland (1990) (26)
- Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function (2018) (26)
- Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. (2009) (26)
- Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism (2017) (26)
- A Hybrid Structural Approach to Analyze Ligand Binding by the Serotonin Type 4 Receptor (5-HT4)* (2013) (26)
- Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases (2019) (26)
- Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. (2010) (26)
- Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. (2010) (25)
- Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. (2016) (25)
- Improvement in vision: a new goal for treatment of hereditary retinal degenerations (2015) (25)
- Is vertebrate phototransduction solved? New insights into the molecular mechanism of phototransduction. (1994) (25)
- Autosomal Recessive Retinitis Pigmentosa and E150K Mutation in the Opsin Gene* (2006) (25)
- Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. (2014) (24)
- Different properties of the native and reconstituted heterotrimeric G protein transducin. (2008) (24)
- Studies of ligand binding to arrestin. (1991) (24)
- A Functional Kinase Homology Domain Is Essential for the Activity of Photoreceptor Guanylate Cyclase 1* (2009) (24)
- Structural properties of arrestin studied by chemical modification and circular dichroism. (1992) (24)
- An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. (2016) (24)
- Arrestin interaction with rhodopsin (2006) (24)
- Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. (2010) (24)
- An Acyl-covalent Enzyme Intermediate of Lecithin:Retinol Acyltransferase* (2010) (24)
- A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. (2017) (24)
- Guanylate cyclase-activating proteins and retina disease. (2007) (23)
- Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. (2016) (23)
- Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. (2016) (23)
- Periscope for noninvasive two-photon imaging of murine retina in vivo. (2015) (22)
- The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. (2016) (22)
- Mechanistic Studies on the Stereoselectivity of the Serotonin 5‐HT1A Receptor (2016) (22)
- Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65 (2018) (22)
- 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. (2013) (22)
- MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice* (2017) (22)
- Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. (2017) (22)
- Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy (2017) (22)
- Two-photon imaging of the mammalian retina with ultrafast pulsing laser. (2018) (21)
- Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase * (2016) (21)
- Identification of Functional Regions of Guanylate Cyclase-Activating Protein 1 (GCAP1) Using GCAP1/GCIP Chimeras (2001) (21)
- Multienzyme analysis of visual cycle. (2000) (21)
- Mechanism of rhodopsin phosphorylation. (1995) (21)
- Separation of phospho‐ and non‐phosphopeptides using reverse phase column chromatography (1995) (21)
- Calcium binding to recoverin: implications for secondary structure and membrane association. (1997) (21)
- Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones (2019) (21)
- Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease (2020) (21)
- Purification and primary structure of Capl, an S-100-related calcium-binding protein isolated from bovine retina. (1994) (21)
- The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements. (2014) (20)
- Heterologous expression of functional G‐protein‐coupled receptors in Caenorhabditis elegans (2012) (20)
- Calcium-Binding Proteins in the Retina (1993) (20)
- Retinoids in the visual cycle: role of the retinal G protein-coupled receptor (2020) (20)
- Inositolhexakisphosphate (InsP6): An antagonist of fibroblast growth factor receptor binding and activity (1994) (19)
- Noninvasive two-photon fluorescence microscopy imaging of mouse retina and RPE through the pupil of the eye (2014) (19)
- Elevated level of protein phosphatase 2A activity in retinas of rd mice. (1991) (19)
- Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. (2015) (19)
- In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration (2022) (19)
- Assays of retinoid dehydrogenases by phase partition. (1993) (18)
- Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage* (2016) (18)
- The kinetics of multiphosphorylation of rhodopsin. (1993) (18)
- A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration (2018) (18)
- Purification of Rhodopsin Kinase from Bovine Rod Outer Segments (1993) (18)
- Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. (2007) (18)
- Evolutionary analysis of rhodopsin and cone pigments: connecting the three‐dimensional structure with spectral tuning and signal transfer (2003) (18)
- Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium* (2016) (18)
- Focus on molecules: guanylate cyclase-activating proteins (GCAPs). (2009) (17)
- Context-dependent compensation among phosphatidylserine-recognition receptors (2017) (17)
- Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. (2016) (17)
- Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. (2015) (17)
- Photoreceptors and Calcium (2002) (17)
- Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. (2016) (17)
- Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). (2000) (17)
- A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. (2015) (17)
- Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice* (2015) (17)
- Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. (1999) (17)
- Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs (2018) (16)
- Photoreceptor guanylate cyclase variants: cGMP production under control. (2003) (16)
- The G protein-coupled receptor rhodopsin: a historical perspective. (2015) (16)
- Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1). (2012) (16)
- Biophysics (communication arising): Is rhodopsin dimeric in native retinal rods? (2003) (16)
- Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. (2019) (16)
- Expansion of First-in-Class Drug Candidates That Sequester Toxic All-Trans-Retinal and Prevent Light-Induced Retinal Degeneration (2015) (16)
- Serum levels of lipid metabolites in age‐related macular degeneration (2015) (16)
- Rational Tuning of Visual Cycle Modulator Pharmacodynamics (2017) (16)
- High‐resolution crystal structures of the photoreceptor glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) with three and four‐bound NAD molecules (2014) (15)
- Crystallization of G protein-coupled receptors. (2013) (15)
- Noninvasive two-photon optical biopsy of retinal fluorophores (2020) (15)
- Serial Block Face‐Scanning Electron Microscopy: A Method to Study Retinal Degenerative Phenotypes (2014) (15)
- Molecular biology and analytical chemistry methods used to probe the retinoid cycle. (2010) (15)
- PAR4 activation involves extracellular loop-3 and transmembrane residue Thr153. (2020) (15)
- Capturing a rhodopsin receptor signalling cascade across a native membrane (2022) (15)
- Use of thallium to identify monovalent cation binding sites in GroEL. (2009) (14)
- Structural approaches to understanding retinal proteins needed for vision. (2014) (14)
- Affinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. (1985) (14)
- Vertebrate phototransduction and the visual cycle (2000) (14)
- Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. (2007) (14)
- R9AP overexpression alters phototransduction kinetics in iCre75 mice. (2014) (14)
- Retinal degeneration in animal models with a defective visual cycle. (2013) (14)
- Light-Induced Translocation of RGS9-1 and Gβ5L in Mouse Rod Photoreceptors (2013) (14)
- Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors (2017) (13)
- Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration (2018) (13)
- Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition (2021) (13)
- Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity. (2014) (13)
- A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6 (2021) (13)
- Rhodopsin dimers in native disc membranes: Neat rows of paired photon receptors are caught on camera in their natural state (2003) (12)
- Determinants shaping the nanoscale architecture of the mouse rod outer segment (2021) (12)
- Visualization of retinoid storage and trafficking by two-photon microscopy. (2010) (12)
- Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains. (2014) (12)
- Rhodopsin and its kinase. (2002) (12)
- Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. (2004) (12)
- Pathways and disease-causing alterations in visual chromophore production for vertebrate vision (2020) (12)
- Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium (2017) (12)
- Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. (2015) (12)
- Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. (2008) (12)
- Identification and Characterization of Novel Inhibitors of Mammalian Aspartyl Aminopeptidase (2014) (12)
- Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases. (2000) (12)
- Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. (2012) (12)
- The role of retinol dehydrogenase 10 in the cone visual cycle (2017) (12)
- Heterogeneous N-terminal acylation of retinal proteins results from the retina's unusual lipid metabolism. (2011) (11)
- Alligator rhodopsin: sequence and biochemical properties. (1995) (11)
- Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. (2018) (11)
- Structural Insights into Activation of the Retinal L-type Ca2+ Channel (Cav1.4) by Ca2+-binding Protein 4 (CaBP4)* (2014) (11)
- Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. (2017) (11)
- Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. (2002) (10)
- The Role of the 11‐cis‐Retinal Ring Methyl Substituents in Visual Pigment Formation (2006) (10)
- Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology (2011) (10)
- Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. (2020) (10)
- HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors* (2012) (10)
- Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. (2010) (10)
- Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue (2017) (9)
- A Mixture of U.S. Food and Drug Administration–Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness (2019) (9)
- Electrostatic Compensation Restores Trafficking of the Autosomal Recessive Retinitis Pigmentosa E150K Opsin Mutant to the Plasma Membrane* (2010) (9)
- Retinol dehydrogenase 8 and ATP‐binding cassette transporter 4 modulate dark adaptation of M‐cones in mammalian retina (2015) (9)
- An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. (2018) (9)
- Crystallization of proteins from crude bovine rod outer segments. (2015) (9)
- Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State (2018) (8)
- Specificity of the chromophore-binding site in human cone opsins (2019) (8)
- Identification of a Single Phosphorylation Site Within Octopus Rhodopsin (1998) (8)
- Multifunctional PEG Retinylamine Conjugate Provides Prolonged Protection against Retinal Degeneration in Mice (2014) (8)
- Imaging G protein–coupled receptor islands (2005) (8)
- Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance (2016) (8)
- Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity (2020) (8)
- Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity (2019) (8)
- Photoaffinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 8-azido-1,N6-ethenoadenosine 5'-triphosphate. (1987) (8)
- Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. (2021) (8)
- Purification and properties of porcine brain aldolase C (1983) (7)
- Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. (2020) (7)
- Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr–rich domain conserved in vertebrates (2019) (7)
- Structural evidence for visual arrestin priming via complexation of phosphoinositols. (2021) (7)
- MicroRNA regulation of critical retinal pigment epithelial functions (2021) (7)
- The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration (2019) (7)
- Function of mammalian M-cones depends on the level of CRALBP in Müller cells (2020) (7)
- Structural analysis of protein prenyl groups and associated C-terminal modifications. (2000) (7)
- Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. (2020) (7)
- Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium (2019) (7)
- Oral synthetic cis-retinoid therapy in subjects with Leber congenital amaurosis (LCA) due to lecithin:retinol acyltransferase (LRAT) or retinal pigment epithelial 65 protein (RPE65) mutations: preliminary results of a phase Ib open label trial (2011) (6)
- Characterization of two-photon vision by measurements of sensitivity threshold (2016) (6)
- X‐ray crystal structure of sangivamycin, a potent inhibitor of protein kinases (1990) (6)
- Two-photon microperimetry with picosecond pulses. (2020) (6)
- Light Inhibition of Bovine Retinal Rod Guanylyl Cyclase Mediated by βγ-Transducin† (1999) (6)
- New GABA modulators protect photoreceptor cells from light‐induced degeneration in mouse models (2018) (6)
- Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation (2020) (6)
- Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. (2010) (6)
- Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. (2017) (6)
- Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates. (2013) (6)
- Retinosomes (2004) (6)
- THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY (2020) (6)
- Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa (2017) (6)
- pH Assay of Rod Outer Segment Cyclic GMP Phosphodiesterase Activity (1993) (5)
- Argonaute High-Throughput Sequencing of RNAs Isolated by Cross-Linking Immunoprecipitation Reveals a Snapshot of miRNA Gene Regulation in the Mammalian Retina (2014) (5)
- Novel targeting strategy for generating mouse models with defects in the retinoid cycle (2003) (5)
- In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope (2021) (5)
- Erratum: Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa (Journal of Biological Chemistry (2003) 278 (14442-14450)) (2003) (5)
- An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease (2021) (5)
- Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. (2019) (5)
- Sensitivity of Mammalian Cone Photoreceptors to Infrared Light (2019) (5)
- Detergents stabilize the conformation of phosphodiesterase 6. (2011) (5)
- Single particle cryo‐EM of the complex between interphotoreceptor retinoid‐binding protein and a monoclonal antibody (2020) (4)
- Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles (2022) (4)
- Phosphorylation of RGS 9-1 by an Endogenous Protein Kinase in Rod Outer Segments * (2001) (4)
- Erratum to: “Phototransduction: crystal clear”[Trends Biochem. Sci. 28 (2003) 479–487] (2003) (4)
- Rhodopsin Signaling and Organization in Heterozygote Rhodopsin (2004) (4)
- New focus on regulation of the rod photoreceptor phosphodiesterase. (2021) (4)
- Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans. (2015) (4)
- Catalytic synthesis of 9-cis-retinoids: mechanistic insights. (2019) (4)
- As Good as Chocolate (2013) (4)
- Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. (2013) (4)
- Focus on vision: 3 decades of remarkable contributions to biology and medicine (2011) (4)
- Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. (2019) (4)
- Vertebrate Phototransduction and the Visual Cycle. Part A: Preface (2000) (4)
- Cloning and Characterization of a Human b , b-Carotene-15 , 15 *-Dioxygenase That Is Highly Expressed in the Retinal Pigment Epithelium (2001) (4)
- Supplemental Information Molecular Organization and ATP-Induced Conformational Changes of ABCA 4 , the Photoreceptor-Specific ABC Transporter (2013) (4)
- A Critical Role of CaBP 4 in the Cone Synapse (2005) (3)
- Thematic Minireview Series on Focus on Vision (2011) (3)
- VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy (2022) (3)
- Mechanism Of All-Trans-retinal Toxicity: Implications For Stargardt’S Disease And Age-related Macular Degeneration (2012) (3)
- Structural Biology of Membrane Proteins (2011) (3)
- Posttranslational Modi fi cations of the Photoreceptor-Speci fi c ABC Transporter ABCA 4 (2011) (3)
- Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by a-toxin ( rhodopsin kinase y phototransduction y photoreceptor cells y cGMP ) (1998) (3)
- Methods for the purification and characterization of calcium-binding proteins from retina (1995) (3)
- Incorporation of vitamin A into milk of wild type and mutant mice (2006) (3)
- The Retinoid Cycle and Retinal Diseases (2005) (3)
- Inhibition of ceramide accumulation in AdipoR1–/– mice increases photoreceptor survival and improves vision (2022) (3)
- Increasing the Stability of Recombinant Human Green Cone Pigment. (2018) (3)
- Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes (2022) (3)
- Dual-substrate Specificity Short Chain Retinol Dehydrogenases (2002) (3)
- Molecular mechanism of visual transduction. (1999) (3)
- Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti (2002) (3)
- Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization (2021) (3)
- Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes. (2003) (3)
- Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. (2020) (3)
- The Phosphorylation of Rhodopsin (1992) (3)
- Stereospecific modulation of dimeric rhodopsin (2019) (3)
- Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing (2020) (3)
- Analysis of Serine, Threonine and Tyrosine Phosphorylation Sites with Mass Spectrometry (1993) (2)
- Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice (2022) (2)
- Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention (2019) (2)
- Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. (2016) (2)
- Guanylate Cyclase-Activating Protein (GCAP) (1995) (2)
- Reprint of "Crystal packing analysis of Rhodopsin crystals" [J. Struct. Biol. 158 (2007) 455-462]. (2007) (2)
- Cloning, expression, and chromosomal localization of the human and mouse GCAP2 gene (1996) (2)
- Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. (2021) (2)
- Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies (2021) (2)
- Arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients (2005) (2)
- Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice (2022) (2)
- Localization of three genes expressed in retina on mouse Chromosome 11 (1995) (1)
- Chapter 1:The Impact of G Protein-coupled Receptor (GPCR) Structures on Understanding Signal Transduction (2011) (1)
- WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration. (2009) (1)
- Crystal structure of Bos taurus opsin at 2.7 Angstrom (2017) (1)
- Role of Toll-Like Receptor 3 in Retinal Pigment Epithelial Cell Death in Rdh8-/-Abca4-/- Mice (2010) (1)
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment. (2022) (1)
- Phosphorylation of 13-demethylrhodopsin (1996) (1)
- 11-Cis-Retinal Is Required for Normal Trafficking of Membrane-Associated Proteins to Cone Photoreceptor Outer Segments (2008) (1)
- Essential Roles of RDH8, ABCA4, and Rods in Modulating Dark Adaptation of Mammalian Cones (2015) (1)
- Inflammatory priming predisposes to age − related retinal degeneration in mice (2012) (1)
- Skunkworks project for Big Pharma. (2017) (1)
- Two–photon imaging of vitamin A in the eye: identification of retinosomes (2004) (1)
- Retinoid Pathway Gene Mutations and the Pathophysiology of Related Visual Diseases (2015) (1)
- Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor (2018) (1)
- Towards functional measurements of vision in the living macaque retina using two-photon fluorescence imaging (2010) (1)
- The Role of the 11‐cis‐Retinal Ring Methyl Substituents in Visual Pigment Formation. (2007) (1)
- Impaired Cone Photoreceptor Phagocytosis Contributes to Retinal Degeneration in a Mouse Model of Enhanced S-cone Syndrome (2011) (1)
- Crowd sourcing difficult problems in protein science* (2017) (1)
- Abnormal expression of GCAP1 and photoreceptor guanylate cyclase in rd chicken retina (1996) (1)
- Erratum: Hippocalcin in the olfactory epithelium: A mediator of second messenger signaling (Biochemical Biophysical Research Communications (2004) 322 (1131-1139) DOI: 10.1016/j.bbrc.2004.07.123) (2005) (1)
- Exploring the Thermodynamics of Activation Pathways of Bovine Rhodopsin with Fast Molecular Dynamics Simulations (2009) (1)
- Quantification of retinol production and removal in photoreceptors in the living primate eye using two-photon ophthalmoscopy (2016) (1)
- Role of bulk water in the hydrolysis of rhodopsin ’ s chromophore (2011) (1)
- Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. (2015) (1)
- Impairment of the Pupillary Light Reflex in Rpe65-/- Mice and Patients with Leber Congenital Amaurosis (2002) (1)
- Structure and Function of G-Protein-Coupled Receptor Kinases 1 and 7 (2016) (1)
- Mouse Cone Dark Adaptation Relies on Two Visual Cycles and Is Substantially Retarded in Mice Lacking RDH8 and ABCA4 (2013) (1)
- Serial Sectioning in SEM: Challenges and Opportunities (2011) (0)
- Stabilization of Meta‐I Rhodopsin Conformation by a Nanobody (2022) (0)
- Crystal structure of a photoactivated rhodopsin (2006) (0)
- The paradoxical role of CCL3 in acute and chronic retinal degeneration (2014) (0)
- THEORETICAL MODEL OF GREEN CONE PIGMENT (2002) (0)
- Crystal structure of human HRASLS2 (2012) (0)
- Crystal structure of RPE65 in complex with MB-002 (2015) (0)
- Two-photon autofluorescence imaging of retinal structure and function in the living primate eye (2015) (0)
- Cryo-EM structure of phosphodiesterase 6 (2019) (0)
- Diversity of GCAPs in teleost: multiple novel GCAPs in zebrafish (Danio Rerio) and pufferfish (Fugu Rubripes) retina (2004) (0)
- Crystal Structure Analysis of Maclura pomifera agglutinin complex with p-nitrophenyl-GalNAc (2010) (0)
- Structural and Functional Adaptations in N1pC/P60 Enzymes Facilitate Retinyl Ester Formation (2015) (0)
- Crystal structure of apocarotenoid oxygenase in the presence of Triton X-100 (2014) (0)
- Crystal Structure Analysis of Maclura pomifera agglutinin (2010) (0)
- Inner Retina Signaling and Well-Preserved Vision during Photoreceptor Degeneration in the P23H Retinitis Pigmentosa Model (2018) (0)
- Synechocystis apocarotenoid oxygenase (ACO) mutant - Trp149Ala (2016) (0)
- EM-structure and functional properties of the rhodopsin-transducin complex (2013) (0)
- Deletion of Guanylate Cyclase 1 (GC1/GC–E) and Guanylate Cyclase 2 (GC2/GC–F) Eliminates Photoreceptor Function (2006) (0)
- A 3.02 angstrom crystal structure of wild-type apo GroEL in a monoclinic space group (2007) (0)
- Functional Characterization of Rhodopsin Monomers and Dimers (2004) (0)
- Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form (2015) (0)
- Crystal structure of the complex of the Cellular Retinal Binding Protein with 9-cis-retinal (2014) (0)
- Crystal structure of bovine RPE65 at 1.9 angstrom resolution (2010) (0)
- ' s personal copy The macular degeneration-linked C 1 QTNF 5 ( S 163 ) mutation causes higher-order structural rearrangements (2014) (0)
- Subretinal Microglia/Macrophages Contribute To Retinal Degeneration Caused by All-trans-retinal (2012) (0)
- Probing the Dimerization Affinity of Visual Opsins (2016) (0)
- In vivo Two-Photon Imaging of Macaque Retina (2010) (0)
- Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration (2022) (0)
- Disruption of the Retinoid Cycle in LRAT-/- and RPE65-/- Mice Results in Similar Patterns of Retinal Degeneration: Cone Opsin Mislocalization With Rapid Cone Degeneration and Slow Rod Degeneration (2007) (0)
- Dicer is required for survival of mature rod photoreceptors (2013) (0)
- 1 Chemistry and Biology of Vision : Introduction (2011) (0)
- Characterizing the Metabolism and Physiological Functions of Dihydroretinoids, Charting a Novel Pathway in the Metabolism of Vitamin A (2006) (0)
- Identification of domains involved in calcium-modulation of bovine photoreceptor guanylate cyclase (1996) (0)
- Protective effect of unbleachable retinal chromophore analogue against light-induced retinal degeneration in mice (2018) (0)
- Crystal Structure of Trimeric gC1q Domain of Human C1QTNF5 associated with Late-onset Retinal Macular Degeneration (2012) (0)
- Issue Information (2020) (0)
- Crystal structure of the C1QTNF5 globular domain in space group P63 (2014) (0)
- Opsins withmutations atthesite ofchromophore attachment constitutively activate transducin butarenotphosphorylated byrhodopsin kinase (1994) (0)
- Endoplasmic Reticulum-Associated Degradation (ERAD) of Mutant Rod Opsin Disrupts Photoreceptor Protein Homeostasis During Retinal Degeneration (2014) (0)
- Crystal structure of rhombohedral crystal form of ground-state rhodopsin (2006) (0)
- Retina Transducin 1 , Phototransduction and the Development of Early Diabetic Retinopathy (2019) (0)
- Photoreceptors and Calcium: Preface (2002) (0)
- Palczewski Crystal Structure of Rhodopsin : A G Protein-Coupled Receptor (2012) (0)
- Endoplasmic reticulum‐associated degradation of mutant rhodopsin disrupts protein homeostasis in photoreceptor cells during retinal degeneration (558.3) (2014) (0)
- Crystal structure of bovine rhodopsin (2001) (0)
- From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation (2023) (0)
- Structure of Fe-CAO1 in complex with beta-fluororesveratrol (2017) (0)
- THEORETICAL MODEL OF BLUE CONE PIGMENT (2002) (0)
- Dissociation of the Heterotrimeric G Protein Complex by Nanobodies: Potential uses in the Modulation of Diverse GPCR Signaling (2018) (0)
- Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice (2022) (0)
- Molecular Imaging of the Visual Cycle (2013) (0)
- Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. (1999) (0)
- Pharmacologic Treatments of a Mouse Model of Age-Related Macular Degeneration Caused by All-Trans-Retinal Clearance Delay (2009) (0)
- Can in vivo two-photon retinal imaging be safely applied in humans? (2016) (0)
- UNMYRISTOYLATED GCAP-2 WITH THREE CALCIUM IONS BOUND (1999) (0)
- NEW UNDERSTANDING OF DIETARY RETINOID ABSORPTION, POSTPRANDIAL PROCESSING AND ACTIONS. (2006) (0)
- Three-dimensional Structure of Guanylyl Cyclase Activating Protein-2 , a Calcium-sensitive Modulator of Photoreceptor (1999) (0)
- Crystal structure of DNPEP, ZnMg form (2012) (0)
- Author response: Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease (2020) (0)
- Retinal derivatives and methods of use thereof in the treatment of visual disorders (2005) (0)
- Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser (2017) (0)
- Capturing a rhodopsin receptor signalling cascade across a native membrane (2022) (0)
- Altered Phototransduction in E150K Rod Opsin Mutant Mice (2012) (0)
- An Image-Based High Throughput Screening Assay for Compounds Mitigating the Effect of All-Trans-Retinal Toxicity in Photoreceptor Degeneration (2020) (0)
- Crystal structure of trigonal crystal form of ground-state rhodopsin (2006) (0)
- Dephosphorylation of visual pigments by PP2A is required for timely dark adaptation of rods and cones (2017) (0)
- Dysfunction Of Retinal Cells By All-trans-retinal And Its Condensation Product A2E (2012) (0)
- Age dependent sensitivity of two-photon isomerization of rhodopsin chromophores in the human retina (Conference Presentation) (2016) (0)
- Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain. (1991) (0)
- Sponge Transgenic Mouse Model Reveals the Important Roles of Mir-183 Cluster in Retina (2011) (0)
- Structural Proteomics From Crude Native Rod Outer Segments (2014) (0)
- A mouse model of Retinitis Pigmentosa with an E150K mutation in the rod opsin gene (2012) (0)
- Crystal structure of Co-CAO1 in complex with piceatannol (2017) (0)
- Identification of a novel small molecule chaperon of rhodopsin and its therapeutic potential in retinal degeneration (2017) (0)
- THEORETICAL MODEL OF RHODOPSIN OLIGOMER (2003) (0)
- Crystal structure of Bos taurus opsin regenerated with 6-carbon ring retinal chromophore (2017) (0)
- Structure of RPE65: P6522 crystal form, iridium derivative (2012) (0)
- Structural and Functional Changes in the ABCA4 Transporter Associated with Mutations that Cause Retinal Degeneration (2014) (0)
- Crystal structure of RPE65 in complex with MB-008 and palmitate (2017) (0)
- THEORETICAL MODEL OF RED CONE PIGMENT (2002) (0)
- MPSA abstracts (1994) (0)
- List of Tables vi List of Figures viii List of Abbreviations ix (2008) (0)
- A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration (2018) (0)
- Genetically-related Inflammatory Priming and Failing Retinal Maintenance Predispose to Age-Related Retinal Degeneration in Mice (2012) (0)
- Structure of RPE65: P65 crystal form grown in Fos-Choline-10 (2012) (0)
- Primary Amines Protect The Retina From Degeneration In Mouse Models: Implications For Stargardt’S Disease And Age-related Macular Degeneration (2012) (0)
- Interphotoreceptor retinoid-binding protein (IRBP) in complex with a monoclonal antibody (F3F5 mAb5) (2020) (0)
- Crystal structure of RPE65 in complex with MB-001 and palmitate (2015) (0)
- Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. (2020) (0)
- Two-photon excited fluorescence scanning laser ophthalmoscope for in vivo imaging of the human eye (2022) (0)
- RUNNING TITLE PAGE RUNNING TITLE : Discovery of small-molecule DNPEP inhibitors (2014) (0)
- In vivo two-photon fluorescence imaging of primate inner retina (2015) (0)
- Enzymatic And Regulatory Properties Of The Native Isozymes Of Retinal Guanylyl Cyclase, RetGC1 And RetGC2 (2011) (0)
- Immuno-TEM/STEM in Retinal Research. (2019) (0)
- Crystal structure of Co-CAO1 (2017) (0)
- Synechocystis apocarotenoid oxygenase (ACO) mutant - Glu150Asp (2016) (0)
- Photoreceptors influence retinal vascular degeneration: retinal degeneration and diabetes (2016) (0)
- Prophylactic Treatment of Optimized Retinylamine Loaded PLA Particles in a Macular Degeneration Mouse Model (2014) (0)
- Crystal structure of Co-CAO1 in complex with resveratrol (2017) (0)
- STRA6: A gatekeeper of neuronal vitamin A homeostasis (2013) (0)
- Context-dependent compensation among phosphatidylserine-recognition receptors (2017) (0)
- Contribution of GPCRs and NADPH oxidase to increased generation of superoxide by retinal photoreceptor cells in elevated glucose (2013) (0)
- Issue Information (2020) (0)
- The role of retinol dehydrogenase 10 in the cone visual cycle (2017) (0)
- Crystal structure of human HRASLS3. (2012) (0)
- Crystal structure of RPE65 at 2.14 angstrom resolution (2009) (0)
- Crystal structure of RPE65 in complex with R-emixustat and palmitate (2015) (0)
- Unique Photoreceptor Cell Death Profile In All-trans-retinal-associated Retinal Degeneration (2011) (0)
- Photoreceptors are a main generator of superoxide in retinas of diabetic mice (2013) (0)
- TWENTY-ONE Crystallization of Proteins from Crude Bovine Rod Outer Segments ☆ (2015) (0)
- Crystal structure of Wild-type GroEL with bound Thallium ions (2009) (0)
- Structure of RPE65: P6522 crystal form grown in ammonium phosphate solution (2012) (0)
- Crystal structure of Fe-CAO1 (2017) (0)
- Features of retinitis pigmentosa defined by high throughput sequencing and wide field imaging (2017) (0)
- Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator (2018) (0)
- Homeostatic plasticity triggered by rod photoreceptor degenerative disease is associated with maintenance of sensitive night vision (2020) (0)
- Comparative genomic analysis reveals a functional evolution of vision across mammals (2016) (0)
- Synechocystis ACO mutant - T136A (2015) (0)
- The sensitivity of human infrared vision is age-dependent (2015) (0)
- Profiling the regulatory networks controlling early steps of phagocytosis in the retinal pigmented epithelium (2018) (0)
- Cloning, expression, and immunolocalization of frog gcaps (1997) (0)
- Species specific genetic signatures in the mammalian eye revealed by RNA-Seq (2014) (0)
- Biophysical analysis of the human POT1‐TPP1 complex reveals functional protein‐protein and protein‐DNA interactions involved in telomere maintenance (926.1) (2014) (0)
- Crystal Structure of the Visual Cycle Isomerase RPE65 (2009) (0)
- Predicting Abca4 Disease Progression: A Strategy for Gene Therapy (2009) (0)
- Co-enzyme Induced Conformational Changes in Bovine Eye Glyceraldehyde 3-Phosphate Dehydrogenase (2014) (0)
- Expression and characterizat on of photoreceptor guanylate cyclases 1 and 2 (1997) (0)
- Delivery and deployment of a ciliary actin dynamics module by PCARE drives the neogenesis of phototransductive membrane disks (2018) (0)
- Low-power two-photon fluorescence imaging of mouse retinal pigmented epithelium in vivo (2016) (0)
- AAV–GC1 Restores Subcellular Distribution of Cone Arrestin and GCAP1 Expression in Cone Cells of the GC1 Ko Mouse (2006) (0)
- Crystal structure of apocarotenoid oxygenase in the presence of C8E6 (2014) (0)
- Crystal Structure Analysis of Maclura pomifera agglutinin complex with Gal-beta-1,3-GalNAc (2010) (0)
- Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate (2021) (0)
- Crystal structure of human guanylate cyclase activating protein‐3 (2006) (0)
- A Drug Delivery System for Sustained Release of 9-cis-Retinoids (2011) (0)
- Dissecting lipid contents in the distinct regions of native retinal rod disk membranes (2021) (0)
- Prevention of photoreceptor degeneration with FDA-accepted compounds (2018) (0)
- Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. (2022) (0)
- The physiological impact of microRNA gene regulation in the retina (2012) (0)
- Accelerated Publications Calcium Modulation of Bovine Photoreceptor Guanylate Cyclase † (0)
- Supporting Information The Mechanism of Ligand-Induced Activation or Inhibition of mand k-Opioid Receptors * * (2015) (0)
- Studies of adipose tissue vitamin A storage and metabolism in mutant mice (2006) (0)
- Partial agonism in GPCRs: role of retinal's ring structure in rhodopsin activation (2005) (0)
- The Structure of Murine Outer Segment Disk Membranes Using Atomic Force Microscopy (2003) (0)
- Genetic signatures of rod and cone-dominant retinas and mouse models of retina degeneration (2016) (0)
- Retinal derivatives and methods of use thereof for the treatment of visual disturbances (2005) (0)
- X-ray Footprinting Studies on Photoactivation of Bovine Rhodopsin (2009) (0)
- Two-photon visual sensitivity of human cones - a psychophysical study (2018) (0)
- Genome editing, a superior therapy for inherited retinal diseases (2023) (0)
- Crystal structure of the complex of the Cellular Retinal Binding Protein Mutant R234W with 9-cis-retinal (2014) (0)
- Crystal structure of HRASLS3/LRAT chimeric protein (2014) (0)
- Crystal structure of RPE65 in complex with MB-004 and palmitate (2017) (0)
- Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration (2014) (0)
- Characterization of Non-visual Photoreception in Isolated Chicken Iris Sphincter Muscle (2003) (0)
- Role of Short-Term Light Adaptation Enabling Clearance of Retinaldehydes in Modulating Retinal Susceptibility to Light-Induced Injury (2018) (0)
- Two-photon noninvasive imaging of murine retina in vivo (2015) (0)
- A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. (2021) (0)
- Crystal structure of RPE65 in complex with retinoid-mimetics and palmitate (2015) (0)
- Small molecules selectively reduce the misfolded rhodopsin that causes retinitis pigmentosa (2019) (0)
- CHAPTER 4 Crystallization of GProtein-Coupled Receptors 2 (2013) (0)
- PNAS201903125 1..10 (2020) (0)
- RPE cells differentiated from human induced pluripotent stem cells show production of the visual chromophore and phagocytosis ability (2014) (0)
- Crystal structure of RPE65 in a lipid environment (2012) (0)
- Adipocytes in a Reduces Lipid Storage Capacity of Activity and γ Proliferator Receptor-Carotene Decreases Peroxisome β , β Metabolism : (2010) (0)
- Anomalous Reactions of the Visual Cycle Initiate Retinal Changes Found in Macular Degeneration (2009) (0)
- Apo-opsin forms a photoactivated rhodopsin-like state (2017) (0)
- Cryo-EM structure of the native rhodopsin dimer from rod photoreceptor cells (2019) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Krzysztof Palczewski?
Krzysztof Palczewski is affiliated with the following schools:
