Kum Kum Khanna
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Why Is Kum Kum Khanna Influential?
(Suggest an Edit or Addition)According to Wikipedia, Kum Kum Khanna is an Indian professor at the QIMR Berghofer Medical Research Institute, also known as Queensland Institute of Medical Research who has published many peer reviewed articles in reputable journals such as in Nature Genetics, Cancer Cell, Nature, Oncogene, and many others. Her most cited article has received 1568 citations since its publication in 2001. she has made seminal discoveries in identifying single-stranded DNA binding proteins, hSSB1 and hSSB2 involved in DNA repair; a novel protein, designated as Cep55, involved in regulation of final stage of cell cycle and have functionally characterized BRCA2 interacting protein, Centrobin.
Kum Kum Khanna's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DNA double-strand breaks: signaling, repair and the cancer connection (2001) (2439)
- From selenium to selenoproteins: synthesis, identity, and their role in human health. (2007) (1189)
- Whole-genome landscape of pancreatic neuroendocrine tumours (2017) (616)
- Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. (2003) (568)
- ATM associates with and phosphorylates p53: mapping the region of interaction (1999) (535)
- ATM-dependent phosphorylation of nibrin in response to radiation exposure (2000) (491)
- Interaction between ATM protein and c-Abl in response to DNA damage (1997) (489)
- A Comprehensive Review on Current Advances in Peptide Drug Development and Design (2019) (324)
- Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation* (2003) (311)
- Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity* (2000) (295)
- Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. (2005) (292)
- Dominant negative ATM mutations in breast cancer families. (2002) (275)
- Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A (2004) (271)
- Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. (2010) (270)
- Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. (1993) (265)
- Role for ATM in DNA damage-induced phosphorylation of BRCA1. (2000) (253)
- A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. (2010) (252)
- Single-stranded DNA-binding protein hSSB1 is critical for genomic stability (2008) (237)
- Involvement of Human MOF in ATM Function (2005) (233)
- Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease. (2015) (229)
- Selenium and selenoproteins in health and disease. (2010) (222)
- Chk2 Activation Dependence on Nbs1 after DNA Damage (2001) (212)
- Cancer risk and the ATM gene: a continuing debate. (2000) (200)
- Rare variants in the ATM gene and risk of breast cancer (2011) (200)
- Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair (2009) (193)
- Calpain activation is upstream of caspases in radiation-induced apoptosis (1998) (189)
- Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms (1997) (185)
- EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. (2013) (181)
- Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks (2009) (176)
- BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage* (2004) (164)
- Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice (2014) (159)
- Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites (2001) (155)
- ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. (1999) (140)
- Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. (2012) (133)
- Breast cancer stem cells: treatment resistance and therapeutic opportunities. (2011) (131)
- Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes (2010) (131)
- HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer (2010) (130)
- Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53 (2001) (123)
- Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks (2004) (121)
- Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. (2006) (118)
- Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. (2006) (117)
- Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair (2009) (116)
- A new non‐catalytic role for ubiquitin ligase RNF8 in unfolding higher‐order chromatin structure (2012) (116)
- Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis. (2016) (113)
- ATM protein kinase: the linchpin of cellular defenses to stress (2011) (113)
- hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response* (2009) (112)
- Subtypes of familial breast tumours revealed by expression and copy number profiling (2010) (110)
- Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. (2012) (109)
- Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. (1997) (105)
- The Redox State of SECIS Binding Protein 2 Controls Its Localization and Selenocysteine Incorporation Function (2006) (105)
- Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51. (2015) (103)
- Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis (2009) (102)
- Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia. (1995) (101)
- The Integrator complex controls the termination of transcription at diverse classes of gene targets (2015) (101)
- UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein. (2001) (100)
- Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis (2016) (99)
- The Plant Isoflavenoid Genistein Activates p53 and Chk2 in an ATM-dependent Manner* (2001) (96)
- Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance (2015) (94)
- LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (2018) (94)
- Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X). (2009) (93)
- Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest (2013) (92)
- Mechanisms of Genomic Instability in Breast Cancer. (2019) (90)
- Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1 (2003) (88)
- Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase. (1995) (88)
- Purification and Characterization of ATM from Human Placenta (2000) (86)
- INTS3 controls the hSSB1-mediated DNA damage response (2009) (83)
- Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. (2014) (83)
- Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation (2005) (79)
- Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer (2014) (78)
- Rad51 supports triple negative breast cancer metastasis (2014) (77)
- CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer (2020) (76)
- Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling (2016) (76)
- Tocotrienol as a potential anticancer agent. (2012) (76)
- hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity (2011) (75)
- A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy (2014) (74)
- The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin. (2015) (73)
- hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex (2010) (72)
- Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage. (2017) (69)
- Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11 (2012) (69)
- Treatment of Triple-Negative Breast Cancer Using Anti-EGFR–Directed Radioimmunotherapy Combined with Radiosensitizing Chemotherapy and PARP Inhibitor (2013) (69)
- Mitotic slippage: an old tale with a new twist (2019) (69)
- A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP* (2007) (69)
- Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by α-lipoic acid (2001) (67)
- EDD Mediates DNA Damage-induced Activation of CHK2* (2006) (67)
- Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites IN VIVO ASSESSMENT USING PHOSPHO-SPECIFIC ANTIBODIES* (2001) (65)
- Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells (2017) (62)
- Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA. (1994) (62)
- Patterns of Genomic Instability in Breast Cancer. (2019) (60)
- The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress (2010) (58)
- Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus (2016) (58)
- Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines (2015) (58)
- Epidermal Growth Factor Sensitizes Cells to Ionizing Radiation by Down-regulating Protein Mutated in Ataxia-Telangiectasia* (2001) (58)
- Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association* (2005) (57)
- CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer (2018) (56)
- Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53. (2001) (56)
- ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1 (2015) (53)
- BRCA1 Modulates Xenobiotic Stress-inducible Gene Expression by Interacting with ARNT in Human Breast Cancer Cells* (2006) (52)
- Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells (1999) (50)
- DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair (2017) (49)
- SCF-FBXO31 E3 Ligase Targets DNA Replication Factor Cdt1 for Proteolysis in the G2 Phase of Cell Cycle to Prevent Re-replication* (2014) (49)
- Krüppel-associated Box (KRAB)-associated Co-repressor (KAP-1) Ser-473 Phosphorylation Regulates Heterochromatin Protein 1β (HP1-β) Mobilization and DNA Repair in Heterochromatin* (2012) (48)
- Ionizing radiation and cell cycle progression in ataxia telangiectasia. (1994) (46)
- p73 Is up‐regulated in a subset of hepatocellular carcinomas (2000) (46)
- Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer (2014) (45)
- Chromosome arm aneuploidies shape tumour evolution and drug response (2020) (45)
- Defective Signaling through the B Cell Antigen Receptor in Epstein-Barr Virus-transformed Ataxia-Telangiectasia Cells* (1997) (43)
- Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals (2005) (43)
- Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks (2014) (42)
- Two ATM variants and breast cancer risk (2005) (42)
- ATM mediated phosphorylation of CHD4 contributes to genome maintenance (2011) (42)
- Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target (1999) (42)
- DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer (2017) (40)
- Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti‐PD‐L1 antibody for treatment of triple‐negative breast cancer (2019) (40)
- ATM and Genome Maintenance: Defining Its Role in Breast Cancer Susceptibility (2004) (40)
- The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. (2009) (40)
- Cep55 stabilization is required for normal execution of cytokinesis (2009) (39)
- Centrobin regulates the assembly of functional mitotic spindles (2010) (37)
- The actin-binding and bundling protein, EPLIN, is required for cytokinesis (2009) (37)
- Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition (2015) (37)
- An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells (1998) (36)
- Functional characterization of alternatively spliced human SECISBP2 transcript variants (2008) (36)
- Chromatinized Protein Kinase C-θ Directly Regulates Inducible Genes in Epithelial to Mesenchymal Transition and Breast Cancer Stem Cells (2014) (35)
- Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer. (2006) (35)
- Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer (2016) (34)
- Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma (2019) (34)
- Enhanced dependency of KRAS‐mutant colorectal cancer cells on RAD51‐dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae (2017) (33)
- Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. (2014) (32)
- MEK5-ERK5 pathway associates with poor survival of breast cancer patients after systemic treatments (2015) (31)
- Gemcitabine and CHK1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma (2014) (31)
- Inactivation of ATM/ATR DNA Damage Checkpoint Promotes Androgen Induced Chromosomal Instability in Prostate Epithelial Cells (2012) (31)
- Involvement of Exo1b in DNA damage-induced apoptosis (2009) (31)
- Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition (2019) (30)
- Expression of a Truncated Brca1 Protein Delays Lactational Mammary Development in Transgenic Mice (2004) (30)
- Potential roles for prions and protein-only inheritance in cancer (2012) (29)
- Cep55 overexpression causes male‐specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling (2018) (29)
- Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib (2015) (28)
- Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers. (2019) (28)
- Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination (2017) (27)
- RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC (2020) (27)
- Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2 (2013) (26)
- Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish (2015) (24)
- Optimizing poly (ADP‐ribose) polymerase inhibition through combined epigenetic and immunotherapy (2018) (23)
- SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. (2010) (23)
- The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells (2017) (22)
- BRCA1 A-Complex fine tunes repair functions of BRCA1 (2011) (22)
- Functional characterization of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1). (2000) (22)
- Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons (2011) (22)
- Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach. (2016) (22)
- Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer (2014) (21)
- Cloning and characterization of a human protein phosphatase 1-encoding cDNA. (1993) (21)
- MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation. (2010) (21)
- Cloning and expression of the ataxia-telangiectasia gene in baculovirus. (1998) (21)
- No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer (2002) (20)
- Mutation analysis of five candidate genes in familial breast cancer (2006) (20)
- Tumor protein D52 represents a negative regulator of ATM protein levels (2013) (20)
- FBXO31 protects against genomic instability by capping FOXM1 levels at the G2/M transition (2017) (20)
- Multidimensional phenotyping of breast cancer cell lines to guide preclinical research (2017) (20)
- Rapamycin resistance in ataxia-telangiectasia. (1996) (18)
- Phosphorylation of Exo 1 modulates homologous recombination repair of DNA double-strand breaks (2010) (18)
- Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer (2016) (18)
- MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells (2019) (18)
- Defective radiation signal transduction in ataxia-telangiectasia cells. (2000) (18)
- Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment (2013) (18)
- DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer (2017) (17)
- Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling (2006) (17)
- Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. (2015) (17)
- Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. (2017) (17)
- INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. (2012) (16)
- Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. (2017) (16)
- Purification and characterization of a DNA-binding protein activated by ionizing radiation. (1992) (16)
- Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation. (1996) (15)
- Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. (1996) (14)
- Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest (2013) (14)
- HER 3 and downstream pathways are involved in colonization of brain metastases from breast cancer (2010) (13)
- BRCA 1-BARD 1 Complexes Are Required for p 53 Ser-15 Phosphorylation and a G 1 / S Arrest following Ionizing Radiation-induced DNA Damage * (2004) (13)
- CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer (2021) (12)
- Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families (2011) (12)
- First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation (2019) (12)
- Cep55 overexpression promotes genomic instability and tumorigenesis in mice (2019) (12)
- Defect in radiation signal transduction in ataxia-telangiectasia. (1994) (12)
- Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer (2019) (11)
- Long noncoding RNAs , CUPID 1 and CUPID 2 , mediate breast cancer risk at 11 q 13 by modulating response to DNA damage (2017) (11)
- BCoR-L1 variation and breast cancer (2007) (11)
- Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore (2019) (11)
- Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic? (2010) (11)
- Watters, D. et al. Cellular localization of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene 14, 1911-1921 (1997) (10)
- Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice (2015) (10)
- High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations (2016) (10)
- Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer (2016) (9)
- Radiation-activated DNA-binding protein constitutively present in ataxia telangiectasia nuclei. (1993) (9)
- RNA interference to enhance radiation therapy: Targeting the DNA damage response. (2018) (9)
- Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families (2017) (9)
- The implication of the SUMOylation pathway in breast cancer pathogenesis and treatment (2020) (8)
- Genetic complementation of radiation response by 3' untranslated regions (UTR) of RNA. (1996) (8)
- RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination. (2018) (7)
- hSSB 1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endonuclease activity (2011) (7)
- Complex-based analysis of dysregulated cellular processes in cancer (2014) (7)
- Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response (2020) (7)
- Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer (2022) (6)
- Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours (2017) (6)
- Microenvironment and Immunology Natural Killer Cells Are Essential for the Ability of BRAF Inhibitors to Control BRAFV 600 E-Mutant Metastatic Melanoma (2014) (6)
- Cellular Responses to DNA Damage and Human Chromosome Instability Syndromes (1998) (6)
- Single-Stranded DNA Binding Proteins Involved in Genome Maintenance (2009) (5)
- Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges. (2011) (5)
- INTS 3 controls the hSSB 1-mediated DNA damage response (2009) (5)
- Author Correction: LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (2018) (5)
- The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking. (2018) (4)
- Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient (2018) (4)
- Abstract 162: DNA methylome in familial breast cancer identifies distinct profiles defined by mutation status (2010) (4)
- Identification of ATM-Interacting Proteins by Co-immunoprecipitation and Glutathione-S-Transferase (GST) Pull-Down Assays. (2017) (4)
- Complexities of pharmacogenomic interactions in cancer (2020) (4)
- GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival (2019) (3)
- Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer (2019) (3)
- Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer (2019) (3)
- Mouse models uncap novel roles of SSBs (2013) (3)
- Defect in radiation signal transduction in ataxia-telangiectasia. (1994) (3)
- Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage. (2006) (3)
- WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis (2021) (2)
- Sensing damage in DNA: ATM and cellular signalling (2000) (2)
- Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis (2021) (2)
- Abstract 3008: CEP55 is a determinant of genomic instability in aneuploid breast cancer cells and facilitates anti-mitotic drugs resistance by interacting directly with HSF1 (2015) (2)
- Targeting BRF2 in Cancer Using Repurposed Drugs (2021) (2)
- Molecular and Cellular Pathobiology INT 6 / EIF 3 E Interacts with ATM and Is Required for Proper Execution of the DNA Damage Response in Human Cells (2012) (1)
- Chromatin Modifications Involved in the DNA Damage Response to Double Strand Breaks (2009) (1)
- Brocade: The National Breast Cancer Foundation Repository of Primary Tumours and Metastases from Breast Cancer Patients (2017) (1)
- 1661PSynergistic inhibition of CEP55 induces mitotic catastrophe and specifically targets aggressive breast cancer (2017) (1)
- DNA Damage Response: From Tumourigenesis to Therapy (2014) (1)
- Differential Regulation of Lacto-/Neolacto- Glycosphingolipid Biosynthesis Pathway Reveals Transcription Factors as Potential Candidates in Triple-Negative Breast Cancer (2021) (1)
- Uncovering molecular mechanisms involved in metastasis to the brain (2012) (1)
- hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage (2021) (1)
- Novel single stranded DNA binding proteins crucial for the DNA damage response (2010) (1)
- DNA Damage Response (2006) (1)
- Role of tumor suppressors in DNA damage response. (2003) (1)
- CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer (2020) (1)
- Peptidyl-prolyl isomerization for cytokinetic abscission (2012) (0)
- Molecular Pathways Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair (2009) (0)
- Identifying genetic vulnerabilities in cancers driven by defects in DNA-damage response (2016) (0)
- Selenium and selenoproteins in health and disease (Forum Editorial) (2010) (0)
- Differentiation of human induced pluripotent or embryonic stem cells decreases the DNA damage response (2016) (0)
- Abstract PR13: Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer (2020) (0)
- Abstract LB-116: Cep55, a master regulator of cytokinesis in breast cancer pathogenesis (2014) (0)
- Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer (2019) (0)
- Author Correction: LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (2019) (0)
- 268The ataxia-telangiectasia gene is involved in intracellular signalling (1996) (0)
- Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice (2022) (0)
- Role of HER3 in brain metastases from primary breast cancer (2012) (0)
- RAD51 supports metastasis via three major mechanisms independent of DNA repair (2015) (0)
- Harnessing DNA-damage response pathways for breast cancer therapy: a synthetic lethality paradigm (2013) (0)
- Two ATM variants, IVS10-6T>G and 1420L>F, and breast cancer risk (2005) (0)
- SSB1/NABP2 and SSB2/NABP1 Have Essential and Overlapping Roles in Maintaining Hematopoietic Stem and Progenitor Cells (2015) (0)
- 1663PTargeting thioredoxin reductase 1 in novel combination therapies in p53 mutant triple negative breast cancer (2017) (0)
- Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies (2021) (0)
- CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors (2022) (0)
- Cancer Therapy : Preclinical Gemcitabine and CHK 1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma (2014) (0)
- High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations (2016) (0)
- Rad51 expression levels predict synthetic lethality and metastatic potential in high grade breast cancers (2012) (0)
- A short ERK5 isoform modulates nucleocytoplasmic shuttling of active ERK5 and associates with poor survival in breast cancer (2021) (0)
- Serendipity, luck and hard work (2018) (0)
- Exploring the HER3 tyrosine kinase as a therapeutic target for treatment of brain metastases (2015) (0)
- Abstract 5138: Development of a high-throughput screen for breast cancer metastatic potential (2012) (0)
- Correction (2018) (0)
- Genomic and transcriptomic landscapes of human brain metastases (2015) (0)
- Chromosome arm aneuploidies shape tumour evolution and drug response (2020) (0)
- Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer (2022) (0)
- Abstract 1144: Dual inhibition of MEK1/2 and PLK1 specifically targets aggressive breast cancer cell population with CEP55 elevated expression (2017) (0)
- SSB1 and SSB2 single-stranded DNA binding proteins are essential for HSC function (2015) (0)
- Correction: BCoR-L1 variation and breast cancer (2008) (0)
- Abstract 6033: Understanding the role of Cep55 in initiation and progression of cancers (2022) (0)
- A Novel Method to Screen for Dominant Negative ATM Mutations in Familial Breast Cancer (2005) (0)
- Abstract LB-256: PDGFRβ blockade bypasses resistance to combined MEK1/2-JAK2 inhibition in triple-negative breast cancer via intratumoral CD8+ T-cells infiltration (2019) (0)
- Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer (2022) (0)
- Abstract P6-10-06: Rational combination therapy against triple-negative breast cancer (2012) (0)
- Abstract PD6-05: Identifying genetic vulnerabilities in cancers driven by defects in DNA-damage response (2016) (0)
- Further Contribution to the Monotypic Genera of Angiosperms in Indian Flora (2016) (0)
- Serendipity, luck and hard work (2018) (0)
- Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer (2019) (0)
- Abstract 2127: SSB1 is essential for embryogenesis and maintenance of genomic stability in mice (2012) (0)
- COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis (2023) (0)
- The adaptor protein ASC controls transplantation outcomes independently of the inflammasome (TRAN1P.951) (2015) (0)
- Advisory Board and Contents (2020) (0)
- WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis (2021) (0)
- Abstract P6-03-11: Erk5 as a therapeutic target in triple negative breast cancer (TNBC) (2015) (0)
- Author response: Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response (2021) (0)
- A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy (2014) (0)
- Targeting BRF2 in Cancer with Repurposed Drugs Using in Silico Methods (2020) (0)
- DNA damage response decreases during induced pluripotent and embryonic stem cell differentiation (2016) (0)
- Title Inactivation Of Atm / atr Dna Damage Checkpoint Promotes Androgen Induced Chromosomal Instability In Prostate Epithelial Cells (2012) (0)
- Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma. (2022) (0)
- Signaling to the Epigenome: New Insights into the Roles of Nuclear Signaling Kinases in the Context of the Immune System and Cancer (2017) (0)
- Single-strandedDNA-bindingproteinhSSB1iscritical for genomic stability (2008) (0)
- SCF-FBXO31 E3 Ligase Targets DNA Replication Factor Cdt1 for Proteolysis in the G 2 Phase of Cell Cycle to Prevent (2014) (0)
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