Lawrence A. Frohman
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Philosophy Biology
Lawrence A. Frohman's Degrees
- PhD Biochemistry University of California, Berkeley
- Doctorate Medicine University of California, San Francisco
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(Suggest an Edit or Addition)Lawrence A. Frohman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27 Kip1 (1996) (1376)
- Criteria for cure of acromegaly: a consensus statement. (2000) (1006)
- Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. (1981) (826)
- Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. (1984) (408)
- Thyroid cancer occurring as a late consequence of head-and-neck irradiation. Evaluation of 1056 patients. (1976) (353)
- Growth hormone-releasing hormone. (1986) (344)
- Guidelines for acromegaly management. (2002) (338)
- Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels. (1971) (304)
- Growth hormone and insulin levels in weanling rats with ventromedial hypothalamic lesions. (1968) (296)
- The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas. (2008) (278)
- Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial. (2009) (274)
- Octreotide as primary therapy for acromegaly. (1998) (253)
- Effect of Vagotomy and Vagal Stimulation on Insulin Secretion (1967) (252)
- Ovarian function in chronic renal failure: evidence suggesting hypothalamic anovulation. (1980) (231)
- Consensus statement: medical management of acromegaly. (2005) (227)
- Metabolic clearance and secretion rates of human prolactin in normal subjects and in patients with chronic renal failure. (1980) (191)
- Regulation of growth hormone secretion. (1992) (180)
- Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia. (1990) (173)
- Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma. (1989) (170)
- Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution. (1981) (159)
- Hyperprolactinemia and impaired pituitary response to suppression and stimulation in chronic renal failure: reversal after transplantation. (1979) (157)
- Plasma insulin and triglyceride levels after hypothalamic lesions in weanling rats. (1969) (151)
- Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor. (1985) (147)
- Feedback regulation of growth hormone (GH)-releasing hormone gene expression by GH in rat hypothalamus. (1988) (144)
- Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice. (1986) (138)
- Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus. (1986) (138)
- Partial purification and characterization of a peptide with growth hormone-releasing activity from extrapituitary tumors in patients with acromegaly. (1980) (138)
- Hyperinsulinemia in tube-fed hypophysectomized rats bearing hypothalamic lesions. (1970) (128)
- Extrahypothalamic growth-hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: plasma GRF levels in 177 acromegalic patients. (1984) (126)
- Loss of central nervous system component of dopaminergic inhibition of prolactin secretion in patients with prolactin-secreting pituitary tumors. (1978) (123)
- Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary manipulation in obese and nonobese subjects. (1988) (119)
- Diagnosis and treatment of acromegaly complications (2003) (117)
- Differential effects of neonatal and adult androgen exposure on the growth hormone secretory pattern in male rats. (1987) (115)
- Human pancreatic tumor growth hormone-releasing factor: dose-response relationships in normal man. (1984) (115)
- Dissociation of systemic and central effects of neurotensin on the secretion of growth hormone, prolactin, and thyrotropin. (1978) (112)
- Decreased hypothalamic growth hormone-releasing hormone content and pituitary responsiveness in hypothyroidism. (1986) (108)
- Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats. (1993) (108)
- Salivary gland neoplasms as a late consequence of head and neck irradiation. (1977) (106)
- Acromegaly associated with a bronchial carcinoid tumor: evidence for ectopic production of growth hormone-releasing activity. (1979) (103)
- Release of somatostatin and thyrotropin-releasing hormone from rat hypothalamic fragments in vitro. (1980) (103)
- Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA) (2010) (100)
- Cloning and characterization of mouse growth hormone-releasing hormone (GRH) complementary DNA: increased GRH messenger RNA levels in the growth hormone-deficient lit/lit mouse. (1989) (98)
- Inhibitory effect of hypothalamic medial preoptic area somatostatin on growth hormone-releasing factor in the rat. (1988) (98)
- Are messenger molecules in microbes the ancestors of the vertebrate hormones and tissue factors? (1983) (98)
- Hypersecretion of growth hormone and prolactin in McCune-Albright syndrome. (1989) (97)
- Role of Growth Hormone (GH)-Releasing Hormone and Somatostatin on Leptin-Induced GH Secretion (1999) (97)
- The effect of alterations in the pituitary-thyroid axis on hypothalamic content and in vitro release of somatostatin-like immunoreactivity. (1980) (96)
- Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12. (2000) (95)
- Growth hormone releasing action of a Pseudomonas endotoxin (piromen). (1967) (92)
- Incidence, prevalence and characteristics of radiation-induced thyroid tumors. (1978) (91)
- Plasma thyroglobulin in detecting thyroid carcinoma after childhood head and neck irradiation. (1977) (90)
- Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene. (1999) (89)
- Growth hormone (GH)-releasing factor stimulates hypothalamic somatostatin release: an inhibitory feedback effect on GH secretion. (1986) (88)
- Hyperphagia and obesity following ventromedial hypothalamic lesions in rats with subdiaphragmatic vagotomy (1978) (86)
- Role of dopamine in the regulation of growth hormone secretion: dopamine and bromocriptine augment growth hormone (GH)-releasing hormone-stimulated GH secretion in normal man. (1987) (85)
- Regional distribution of immunoreactive neurotensin in monkey brain (1979) (83)
- Hyperglycemia and hyperglucagonemia following neurotensin administration. (1976) (81)
- Metabolic clearance and production rates of human growth hormone in subjects with normal and abnormal growth. (1970) (80)
- Somatotroph hyperplasia without pituitary adenoma associated with a long standing growth hormone-releasing hormone-producing bronchial carcinoid. (1994) (79)
- Neuropharmacologic control of neuroendocrine function in man. (1975) (78)
- Effect of lesion size in the ventromedial hypothalamus on growth hormone and insulin levels in weanling rats. (1970) (77)
- A neuroendocrine study of supersensitivity in tardive dyskinesia. (1977) (77)
- Evidence for a limited growth hormone (GH)-releasing hormone (GHRH)-releasable quantity of GH: effects of 6-hour infusions of GHRH on GH secretion in normal man. (1985) (75)
- Central nervous system mediated inhibition of insulin secretion due to 2-deoxyglucose. (1973) (74)
- Suppression of cold-stimulated thyrotropin secretion by antiserum to thyrotropin-releasing hormone. (1977) (74)
- Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid. (1998) (73)
- Central nervous system-mediated stimulation of glucagon secretion in the dog following 2-deoxyglucose. (1976) (73)
- Effects of ventromedial hypothalamic destruction in rats with preexisting streptozotocin-induced diabetes. (1972) (72)
- Plasma growth hormone responses to constant infusions of human pancreatic growth hormone releasing factor. Intermittent secretion or response attenuation. (1984) (71)
- Blunted growth hormone (GH) response to GH-releasing hormone in hypothyroidism resolves in the euthyroid state. (1985) (71)
- Effects of hyothalamic lesions at different loci on development of hyperinsulinemia and obesity in the weanling rat (1971) (71)
- Release of somatostatin-like immunoreactivity from incubated rat hypothalamus and cerebral cortex. Effects of glucose and glucoregulatory hormones. (1982) (71)
- Liver-Derived IGF-I Regulates GH Secretion at the Pituitary Level in Mice. (2001) (70)
- Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis (2002) (70)
- Glucocorticoids Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression (2000) (69)
- Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels. (1997) (69)
- Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels. (1999) (67)
- Pre- and postnatal developmental changes in hypothalamic content of rat growth hormone-releasing factor. (1987) (67)
- Adipose tissue metabolism of weanling rats after destruction of ventromedial hypothalamic nuclei: effect of hypophysectomy and growth hormone. (1970) (65)
- A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance. (1976) (63)
- Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. (1993) (63)
- Metabolic clearance and plasma disappearance rates of human pancreatic tumor growth hormone releasing factor in man. (1984) (63)
- Hypothalamic Stimulation of Growth Hormone Secretion (1968) (62)
- Normal physiology of hypothalamic pituitary regulation. (2008) (60)
- A RADIOIMMUNOLOGICAL ASSAY METHOD FOR INSULIN USING INSULIN-125I AND GEL FILTRATION. (1965) (59)
- Involvement of hypothalamic somatostatin in the suppression of growth hormone secretion by central corticotropin-releasing factor in conscious male rats. (1985) (58)
- Neurotensin release by rat hypothalamic fragments in vitro (1981) (58)
- Plasma growth hormone responses and growth retardation of hypothyroidism. (1968) (57)
- Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat. (1992) (57)
- Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis. (1992) (56)
- Growth hormone secretion in the rat: metabolic clearance and secretion rates. (1970) (54)
- Effects of intravenous, subcutaneous, and intranasal administration of growth hormone (GH)-releasing hormone-40 on serum GH concentrations in normal men. (1985) (53)
- Stimulation of Prolactin and Growth Hormone Secretion by Muscimol, a γ-Aminobutyric Acid Agonist (1978) (53)
- Acute effects of human growth hormone on insulin secretion and glucose utilization in normal and growth hormone deficient subjects. (1967) (52)
- Ectopic growth hormone-releasing factor and dibutyryl cyclic adenosine monophosphate-stimulated growth hormone release in vitro: effects of corticosterone and estradiol. (1983) (52)
- Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice. (1988) (52)
- Clinical review 22: Therapeutic options in acromegaly. (1991) (51)
- Growth Hormone-Dependent Regulation of Pituitary GH Secretagogue Receptor (GHS-R) mRNA Levels in the Spontaneous Dwarf Rat (1998) (51)
- Secretagogues and the somatotrope: signaling and proliferation. (2000) (51)
- Ectopic growth hormone releasing factor stimulates growth hormone release from human somatotroph adenomas in vitro. (1983) (51)
- Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas. (2005) (51)
- Medical management of acromegaly due to ectopic production of growth hormone-releasing hormone by a carcinoid tumor. (1988) (51)
- Ectopic production of growth hormone-releasing factor by carcinoid and pancreatic islet tumors associated with acromegaly. (1981) (51)
- Ontogenesis of growth hormone-releasing hormone neurons in the rat hypothalamus. (1986) (51)
- Somatostatin-like immunoactivity and biological activity is present in Tetrahymena pyriformis, a ciliated protozoan. (1982) (50)
- Food intake in hypothalamic obesity. (1974) (50)
- Thyrotropin-releasing hormone stimulates growth hormone release from the anterior pituitary of hypothyroid rats in vitro. (1984) (50)
- The role of the cholinergic pathway in growth hormone feedback. (1991) (50)
- Clinical neuropharmacology of hypothalamic releasing factors. (1972) (49)
- The diurnal variation of immunoreactive thyrotropin-releasing hormone and somatostatin in the cerebrospinal fluid of the rhesus monkey. (1981) (49)
- Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus. (1995) (49)
- Inhibitory effect of the ovaries on neonatal androgen imprinting of growth hormone secretion in female rats. (1987) (49)
- Tissue-specific transcription initiation and effects of growth hormone (GH) deficiency on the regulation of mouse and rat GH-releasing hormone gene in hypothalamus and placenta. (1991) (48)
- Hypothalamic hyperinsulinemia and obesity: role of adrenal glucocorticoids. (1983) (48)
- Big growth hormone (GH): conversion to small GH without peptide bond cleavage. (1975) (47)
- Effect of Diet on the Glucose Tolerance and Plasma Insulin Levels of the Sand Rat (Psammomys Obesus) (1966) (47)
- A meiotic recombination in a new isolated familial somatotropinoma kindred. (2004) (47)
- Ectopic hormone production. (1981) (47)
- Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist. (1997) (47)
- Delayed TSH release in anorexia nervosa following injection of thyrotropin-releasing hormone (TRH) (1982) (47)
- Differential effects of somatostatin (SRIH) and a SRIH analog, SMS 201-995, on the secretion of growth hormone and thyroid-stimulating hormone in man. (1988) (47)
- Studies of growth hormone secretion in children: normal, hypopituitary and constitutionally delayed. (1967) (46)
- Factors modifying plasma insulin and glucose responses to ventromedial hypothalamic stimulation. (1974) (46)
- Dissociation of prolactin-releasing activity from thyrotropin-releasing hormone in porcine stalk median eminence. (1976) (44)
- Characterization of growth hormone of different molecular weights in rat, dog and human pituitaries. (1972) (44)
- Effect of hypophysectomy on hypothalamic growth hormone-releasing factor content and release in the rat. (1987) (44)
- Evidence for a defect in growth hormone-releasing factor signal transduction in the dwarf (dw/dw) rat pituitary. (1991) (44)
- Chapter 20 – Growth Hormone: Structure, Function, and Regulation of Secretion (2016) (43)
- VMH obesity reduced but not reserved by scopolamine methyl nitrate (1979) (43)
- Immunohistochemical analysis of human growth hormone-releasing hormone gene expression in transgenic mice. (1989) (42)
- DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. (1994) (41)
- The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback. (2001) (41)
- Growth hormone synthesis by rat pituitaries in vitro: effect of age and sex. (1970) (41)
- Relationship of growth hormone to the growth retardation associated with maternal dietary restriction. (1971) (41)
- Lack of effect of drinking water barium on cardiovascular risk factors. (1990) (41)
- Stimulatory effect of thyroid hormone on growth hormone gene expression in a human pituitary cell line. (1993) (40)
- Thyroid scintigram. Sensitivity with sodium pertechnetate Tc 99m and gamma camera with pinhole collimator. (1976) (40)
- Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats. (1999) (40)
- CNS peptides and glucoregulation. (1983) (39)
- Plasma growth hormone responses to electrical stimulation of the hypothalamus in the rat. (1971) (39)
- Modulation of pituitary somatostatin receptor subtype (sst1-5) messenger ribonucleic acid levels by changes in the growth hormone axis. (2000) (39)
- Hypothalamic obesity in female rats in absence of vagally mediated hyperinsulinemia. (1980) (38)
- Growth hormone: independent release of big and small forms from rat pituitary in vitro. (1975) (38)
- Effects of thyroid hormone deficiency and replacement on rat hypothalamic growth hormone (GH)-releasing hormone gene expression in vivo are mediated by GH. (1990) (37)
- Neurotransmitters as Regulators of Endocrine Function (1975) (37)
- Prolactin-suppressive effects of two aminotetralin analogs of dopamine: their use in the characterization of the pituitary dopamine receptor. (1979) (37)
- Obesity-associated decrease in growth hormone-releasing hormone gene expression: a mechanism for reduced growth hormone mRNA levels in genetically obese Zucker rats. (1993) (36)
- Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly. (1997) (36)
- Growth hormone and insulin-like growth factor-I measurements in high growth (hg) mice. (1991) (36)
- Isolated Familial Somatotropinoma (2005) (36)
- Central nervous system-mediated stimulation of prolactin secretion by cimetidine, a histamine H2-receptor antagonist: impaired responsiveness in patients with prolactin-secreting tumors and idiopathic hyperprolactinemia. (1980) (35)
- The role of vagally-mediated hyperinsulinemia in hypothalamic obesity (1982) (35)
- p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation (2000) (35)
- Drug control of hyperglycemia and inhibition of insulin secretion due to centrally administered 2-deoxy-D-glucose. (1973) (34)
- Hypothalamic obesity in the weanling rat: effect of diet upon hormonal and metabolic alterations. (1971) (34)
- Diethylstilbestrol inhibits tumor growth and prolactin production in rat pituitary tumors. (1985) (34)
- "Large" growth hormone: ribonucleic acid-associated precursor of other growth hormone forms in rat pituitary. (1974) (34)
- Effect of passive immunization with an antiserum to thyrotropin (TSH)-releasing hormone on plasma TSH levels in thyroidectomized rats. (1978) (33)
- Temporal Relationship of Tissue Somatostatin-like Immunoreactivity to Metabolic Changes in Genetically Obese and Diabetic Mice (1980) (33)
- Expression Analysis of Hypothalamic and Pituitary Components of the Growth Hormone Axis in Fasted and Streptozotocin-Treated Neuropeptide Y (NPY)-Intact (NPY+/+) and NPY-Knockout (NPY –/–) Mice (2005) (32)
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. (2006) (32)
- [27] Measurement of growth hormone-releasing factor (1986) (32)
- Neurotensin Hyperglycemia: Evidence for Histamine Mediation and the Assessment of a Possible Physiologic Role (1978) (32)
- The endocrine function of the pancreas. (1969) (32)
- Concomitant association between high plasma levels of growth hormone and low hepatic mixed-function oxidase activity in the young rat. (1974) (31)
- Growth hormone synthesis and release in vitro: effects of partially purified hypothalamic extract. (1972) (31)
- Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. (2009) (30)
- Effects of porcine stalk median eminence and prostaglandin E2 on rat growth hormone secretion in vivo and their inhibition by somatostatin. (1975) (30)
- New insights into the regulation of somatotrope function using genetic and transgenic models. (1996) (30)
- ADIPSIC DIABETES INSIPIDUS: A REVIEW. (2016) (29)
- The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling. (2001) (29)
- Biological effects of an ectopic growth hormone-releasing peptide in cultured adenohypophyseal cells: comparison with growth hormone-releasing activity of porcine hypothalamus. (1982) (29)
- Acromegaly: what constitutes optimal therapy? (1996) (29)
- Hypothalamic stimulation of growth hormone secretion. (1969) (28)
- Effect of caloric restriction on the glucose tolerance and plasma insulin of the sand rat. (1967) (28)
- Studies of insulin sensitivity in vivo in weanling rats with hypothalamic obesity. (1972) (28)
- Beta-adrenergic modulation of growth hormone (GH) autofeedback on sleep-associated and pharmacologically induced GH secretion. (1989) (27)
- Hypothalamic obesity: Comparison of radio-frequency and electrolytic lesions in male and female rats (1986) (27)
- Ectopic production of somatostatin-like immuno- and bioactivity by cultured human pulmonary small cell carcinoma. (1980) (27)
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. (2006) (27)
- Modulation of somatostatin binding to rat pituitary membranes by exogenously administered growth hormone. (1985) (26)
- Efficacy and safety of an octreotide implant in the treatment of patients with acromegaly. (2013) (26)
- Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy (2007) (26)
- 99mTc-pertechnetate thyroid scintigraphy in patients predisposed to thyroid neoplasms by prior radiotherapy to the head and neck. (1975) (25)
- Continuing occurrence of thyroid nodules after head and neck irradiation. Relation to plasma thyroglobulin concentration. (1981) (25)
- p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. (2005) (24)
- Growth-hormone-releasing factor. (1983) (24)
- Diabetes in the Seneca Indians: Plasma Insulin Responses to Oral Carbohydrate (1969) (24)
- Somatostatin-like immunoactivity and biological activity is present in a human pheochromocytoma. (1983) (24)
- Growth hormone synthesis and secretion by a somatomammotroph cell line derived from normal adult pituitary of the rat. (1988) (24)
- Inhibitory feedback effects of prolactin on its secretion involve central nervous system dopaminergic mediation. (1983) (24)
- Familial somatotropinomas: Clinical and genetic aspects (1999) (23)
- Immunologic and biologic properties of antibodies to a glucagon-serum albumin polymer. (1970) (23)
- Impaired inhibitory effects of somatostatin on growth hormone (GH)-releasing hormone stimulation of GH secretion after short term infusion. (1990) (22)
- Tissue distribution and molecular heterogeneity of human growth hormone-releasing factor in the transgenic mouse. (1990) (22)
- Metabolism of intravenously injected 14 C-glucose in weanling rats with hypothalamic obesity. (1972) (22)
- Ectopic hormone production by tumors: growth hormone-releasing factor (1984) (21)
- Heterogeneity of purified human pituitary luteinizing hormone: effect on hormone measurement by radioimmunoassay. (1975) (21)
- Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor (2012) (21)
- The tyrosine hydroxylase-human growth hormone (GH) transgenic mouse as a model of hypothalamic GH deficiency: growth retardation is the result of a selective reduction in somatotrope numbers despite normal somatotrope function. (1996) (21)
- Hypothalamic somatostatin mediates the suppression of growth hormone secretion by centrally administered thyrotropin-releasing hormone in conscious rats. (1985) (20)
- Plasma growth hormone responses to intrapituitary injections of growth hormone releasing factor (GRF) in the rat. (1971) (20)
- CONSENSUS Guidelines for Acromegaly Management (2002) (20)
- Nonirritative lesions of VMH: effects on plasma insulin, obesity, and hyperreactivity. (1985) (19)
- Evidence for lactotroph dopamine resistance in idiopathic hyperprolactinemia. (1983) (19)
- Ectopic growth hormone-releasing hormone secretion by a metastatic bronchial carcinoid tumor: a case with a non hypophysial intracranial tumor that shrank during long acting octreotide treatment (2007) (19)
- Effect of catecholamines on somatostatin secretion by isolated perfused rat stomach. (1981) (18)
- Six‐month follow‐up in weanling rats with ventromedial and dorsomedial hypothalamic lesions: Somatic, endocrine, and metabolic changes (1975) (18)
- Development of neuroepithelial tumors of the adrenal medulla in transgenic mice expressing a mouse hypothalamic growth hormone-releasing hormone promoter-simian virus-40 T-antigen fusion gene. (1994) (18)
- Impaired growth hormone-releasing hormone signal transduction in the dwarf (dw) rat is independent of a generalized defect in the stimulatory G-protein, Gs alpha. (1993) (18)
- Discordant effects of insulin-hypoglycemia on growth hormone (GH)-releasing hormone-stimulated GH and thyrotropin (TSH)-releasing hormone-stimulated TSH secretion. (1988) (17)
- Comparison of the sensitivity of growth hormone secretion to somatostatin in vivo and in vitro in acromegaly. (1988) (17)
- Measurement of growth hormone-releasing factor. (1986) (17)
- Gonadal function in women with chronic renal failure: a study of the hypothalamo-pituitary-ovarian axis. (1977) (17)
- Hyperinsulinemia in rats with ventromedial hypothalamic lesions: role of hyperphagia. (1984) (17)
- Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening. (2010) (16)
- Potential Therapeutic Indications for Growth Hormone and Growth Hormone‐releasing Hormone in Conditions other than Growth Retardation (1986) (15)
- Interaction of ethanol with signal transduction mechanisms mediating growth hormone release by rat pituitary cells in vitro. (1992) (15)
- Insulin responsiveness in vitro of diaphragm and adipose tissue from weanling rats with hypothalamic obesity. (1972) (14)
- TRH immunoreactivity in human urine: evidence for dissociation from TRH. (1977) (14)
- Ectopic GRH Syndromes (1987) (14)
- Regulation of growth hormone-releasing hormone gene expression and biosynthesis. (1989) (14)
- Somatostatin-like immunoreactivity in transplantable medullary carcinoma of rat thyroid: partial chromatographic and biological characterization. (1980) (14)
- Growth Hormone‐Releasing Hormone: Discovery, Regulation, and Actions (2011) (14)
- THE ROLE OF NEUROTENSIN IN THE REGULATION OF CARBOHYDRATE METABOLISM AND IN DIABETES * (1982) (13)
- Diurnal variation in release of somatostatin-like immunoreactivity from incubated, rat hypothalamus and cerebral cortex. (1982) (13)
- Hypertriglyceridemia in Weanling Rats with Hypothalamic Obesity (1971) (13)
- Ectopic Growth Hormone-Releasing Factor Syndromes (1986) (13)
- Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation. (2009) (13)
- Controversy about Treatment of Growth HormoneDeficient Adults: A Commentary (2002) (13)
- Growth hormone-releasing hormone immunoreactivity in mouse placenta, maternal blood, and amniotic fluid: molecular characterization and secretion from primary cell cultures in vitro. (1995) (12)
- Liver-derived IGF-I regulates GH secretion at the pituitary level in mice. (2001) (12)
- Somatostatin secretion and action in the regulation of growth hormone secretion. (1990) (12)
- Relationship between plasma corticosterone and insulin levels in rats with ventromedial hypothalamic lesions (1984) (12)
- Effect of ventromedial hypothalamic lesions on the secretion of somatostatin, insulin, and glucagon by the perfused rat pancreas. (1980) (11)
- Scintigraphic thyroid abnormalities after radiation. A controlled study with 99mTc pertechnetate scanning. (1982) (11)
- Identification of a putative GH-releasing factor (GRF) batch as predominantly ovine CRF with a small quantity of human GRF. (1986) (11)
- Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. (2006) (11)
- Glucose and fatty acid utilization by tissues of weanling rats with ventromedial hypothalamic lesions. (1968) (11)
- An immunological approach to the study of protein conformational heterogeneity: its application to growth hormone. (1978) (10)
- Immunoreactive Neurotensin in the Pancreas of Genetically Obese and Diabetic Mice: A Longitudinal Study (1983) (10)
- Differential sensitivity of growth hormone-releasing hormone and somatostatin release from perifused mouse hypothalamic fragments in response to glucose deficiency. (1993) (10)
- Alpha Subunit of Glycoprotein Hormone: Presence in Peripheral Serum after LHRH (1975) (10)
- Growth hormone-releasing factor analogs with hydrophobic residues at position 19. Effects on growth hormone releasing activity in vitro and in vivo, stability in blood plasma in vitro, and secondary structure. (1992) (10)
- A subcutaneous octreotide hydrogel implant for the treatment of acromegaly. (2012) (10)
- Growth hormone and prolactin secretion in cultured somatomammotroph cells. (1990) (10)
- Plasma immunoreactive TSH: spurious elevation due to antibodies to bovine TSH which cross-react with human TSH. (1982) (10)
- Ontogenesis of peptide-histidine-isoleucine (PHI)-containing neurons in the suprachiasmatic nucleus (SCN) of the rat (1987) (10)
- Hypothalamic dysfunction associated with hemochromatosis. (1985) (9)
- Lack of effect of drinking water chlorine on lipid and thyroid metabolism in healthy humans. (1993) (9)
- The hypothalamus and metabolic control. (1971) (9)
- Effect of the dopa decarboxylase inhibitor MK-486 on L-dopa-induced inhibition of prolactin secretion: evidence for CNS participation in the L-dopa effects. (1977) (9)
- Growth hormone-releasing hormone and pituitary somatotrope proliferation. (2002) (9)
- The Role of Hypothalamic Hormones in the Control of Growth Hormone Secretion and of Growth (1988) (9)
- The incidence of leukemia and related diseases in patients with rheumatoid (ankylosing) spondylitis treated with x-ray therapy. (1960) (9)
- The pituitary gland, 2nd ed. (1996) (9)
- A comparison of transcriptional regulatory element activities in transformed and non-transformed rat anterior pituitary cells (1991) (8)
- Pituitary Tumors in Pregnancy (2001) (8)
- Large growth hormone: evidence for the association of growth hormone with another protein moiety in the rat pituitary. (1973) (8)
- Neuroanatomic localization of the inhibitory effect of TRH on growth hormone secretion. (1987) (8)
- SURVEILLANCE OF STAPHYLOCOCCAL INFECTIONS IN BELLEVUE HOSPITAL, NEW YORK. (1964) (8)
- Acute effects of alloxan- and streptozotocin-induced insulin deficiency on somatostatin and glucagon secretion by the perfused isolated rat pancreatico-duodenal preparation (2004) (8)
- Effects of drinking water monochloramine on lipid and thyroid metabolism in healthy men. (1993) (8)
- Radio-frequency vs. electrolytic VMH lesions: differential effects on plasma hormones. (1988) (8)
- Effect of dorsomedial hypothalamic lesions before and after placement of obesity-producing ventromedial hypothalamic lesions in the weanling male rat. (1974) (8)
- Isolated familial somatotropinomas: clinical and genetic considerations. (2003) (8)
- Alterations in circulating human chorionic gonadotropin free alpha-subunit in insulin-dependent diabetic pregnancy: correlation with maternal characteristics. (1990) (8)
- The effect of intravenous growth hormone infusion on cerebrospinal fluid somatostatin levels in the rhesus monkey (1982) (8)
- Use of protein A--containing Staphylococcus aureus as an immunoadsorbent in radioimmunoassays to separate antibody-bound from free antigen. (1979) (8)
- Ectopic growth hormone-releasing factor stimulates growth hormone secretion in the urethane-anesthetized rat in vivo. (1983) (8)
- Impaired generation of cyclic adenosine 3',5'-monophosphate in a somatomammotroph cell line derived from dwarf (dw) rat anterior pituitaries. (1991) (8)
- A neuroendocrine overview of aging (1994) (8)
- Discordant effects of endogenous and exogenous somatostatin on growth hormone-releasing hormone secretion from perifused mouse hypothalami. (1995) (8)
- Multiphasic effect of porcine stalk-median eminence extract on growth hormone release from perifused rat pituitaries. (1978) (8)
- Effect of insulin on growth hormone (GH) induction by cortisol in rat pituitary tumor cells. (1970) (7)
- Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist. (1978) (7)
- Cellular Physiology of Growth Hormone Releasing Hormone (1996) (7)
- Mouse hypothalamic growth hormone-releasing hormone and somatostatin responses to probes of signal transduction systems (1993) (7)
- Failure of bromocriptine to lower plasma catecholamines in normal men and women. (1982) (7)
- Inhibition and stimulation of rat growth hormone secretion in vitro by hypothalamic extracts. (1974) (7)
- Comparison of radio-frequency and electrolytic lesions of the paraventricular hypothalamic nucleus (1989) (7)
- Familial acromegaly. (2004) (7)
- Differential Effects of Insulin- and Proinsulin-Induced Hypoglycemia on Pituitary Hormone and Catecholamine Secretion (1987) (7)
- Pathogenesis of familial acromegaly. (2010) (7)
- Studies of dopaminergic mechanisms in hyperprolactinemic states. (1981) (7)
- Growth Hormone‐Releasing Hormone: Structure, Gene Expression and Molecular Heterogeneity (1990) (7)
- The Effect of Lateral Hypothalamic Lesions in Weanling Rats Bearing Lesions in the Ventromedial Hypothalamic Nuclei (1973) (6)
- Clinical and genom-wide linkage studies of a multigénérational family with acromegaly and the exclusion of requiem gene (2002) (6)
- Discussion Session 4 (1990) (6)
- Hypothalamic obesity: Comparison of radio-frequency and electrolytic lesions in weanling rats (1989) (6)
- The Physiological and Pharmacological Control of Anterior Pituitary Hormone Secretion (1984) (6)
- Effects of glucocorticoid administration to rats on in vitro intermediary metabolism. (1974) (5)
- ECTOPIC PRODUCTION OF A GROWTH HORMONE-RELEASING FACTOR BY TUMORS (1981) (5)
- Growth hormone releasing hormone and somatostatin in the physiology and pathophysiology of growth hormone secretion (1989) (5)
- Synthesis and biological evaluation of mouse growth hormone-releasing factor. (2009) (5)
- Recurrent thiocyante intoxication, with pancytopenia, hypothyroidism and psychosis. (1963) (5)
- Biosynthesis of human growth hormone-releasing hormone (hGRH) in the pituitary of hGRH transgenic mice. (1991) (5)
- SMS 201-995: Studies in Acromegaly and in Normal Menxs (1986) (5)
- Pancreatic immunoreactive neurotensin (ir-nt) in obese (ob) and diabetes (db) mutant mice: a longitudinal study. Abstr. (1980) (4)
- Growth hormone-releasing factor: a neuroendocrine perspective. (1984) (4)
- Cheap Hot Sale Top Quality DIY Sewing PU Leather Warm Steering Wheel Cover (2006) (4)
- Expression of a cytomegalovirus-human growth hormone-releasing hormone precursor fusion gene in transfected GH3 cells (1990) (4)
- Integrity of central dopaminergic system in women with postpartum hyperprolactinemia. (1982) (4)
- Alpha Subunit of Glycoprotein Hormone: Presence in Peripheral Serum after LHRH (1975) (4)
- State-of-the-art strategies for the diagnosis and management of acromegaly (2001) (4)
- Stimulation of Insulin Secretion in Rats by Pargyline and Mebanazine (1971) (4)
- RELATIONSHIP OF ABSCESS FORMATION IN MICE, GUINEA-PIGS AND RABBITS TO ANTISTAPHYLOCOCCAL ACTIVITY OF THEIR TISSUES AND BLOOD SERUM. (1963) (4)
- Expression of a fusion gene consisting of the mouse growth hormone-releasing hormone gene promoter linked to the SV40 T-antigen gene in transgenic mice (1998) (4)
- The role of AIP in familial acromegaly (2007) (4)
- The "empty" sella. (2007) (3)
- Chapter 10 – Animal Models of Growth Hormone Deficiency as Tools to Study Growth Hormone Releasing Mechanisms (1999) (3)
- Endocrine and neuroendocrine regulation of cell function and growth (1991) (3)
- The empty sella. (2007) (3)
- Diseases of hypothalamic releasing factors. (1976) (3)
- Possible evidence for the existence of a growth hormone fragment in porcine pituitary. (1977) (3)
- Postabsorptive hyperinsulinemia in rats with subdiaphragmatic vagotomy (1981) (3)
- Octreotide pharmacokinetics and biochemical control of acromegaly using a subcutaneous octreotide hydrogel implant (2011) (3)
- Growth hormone-releasing activity in extracts of bronchial carcinoid and pancreatic islet tumors associated with acromegaly. (1979) (3)
- Acute effects of alloxan- and streptozotocin-induced insulin deficiency on somatostatin and glucagon secretion by the perfused isolated rat pancreatico-duodenal preparation (1981) (3)
- Modulation of Pituitary Somatostatin Receptor Subtype (sst1-5) mRNA Levels by Growth Hormone (GH)-Releasing Hormone in Purified Somatotropes (2003) (2)
- Use of Transgenic and Genetic Models to Study the Neuroendocrine Regulation of Growth Hormone Secretion (1993) (2)
- Modulation of somatostatin binding to rat pituitary membranes by exogenously administered growth hormone (1984) (2)
- Central glucoprivation: Some physiological effects induced by the intraventricular administration of 2-deoxy-d-glucose (2005) (2)
- Tumors in Patients with Acromegaly (1980) (2)
- Hyperprolactinemia associated with chronic renal failure in the rat. (1986) (2)
- The pituitary incidentaloma beyond the first year of follow-up. (1990) (2)
- Irradiation and thyroid carcinoma: legacy and controversy. (1976) (2)
- Clinical and laboratory diagnosis of acromegaly (2013) (1)
- Newer understanding of human hypothalamic-pituitary disease obtained through the use of synthetic hypothalamic hormones. (1978) (1)
- Regioal distribution of immunoreactive neurotension in monkey brain. (1979) (1)
- In vivo and in vitro metabolism in hypothalamic obesity (1972) (1)
- Management of Pituitary Incidentalomas (2008) (1)
- The role of the aryl hydrocarbon receptor-interacting protein gene in familial (2008) (1)
- Genetic and Transgenic Models to Investigate the Growth Hormone Axis and Sexual Dimorphism (1999) (1)
- Nodules in irradiated thyroids. (1980) (1)
- Octreotide Treatment of Acromegaly (2020) (1)
- Who needs growth hormone therapy? Growth hormone helps some, but its use as an "anti-aging" agent is dubious. (2002) (1)
- 20 Growth Hormone (GH) Responsiveness to Stimulation by Insulin Hypoglycemia, 2. Arginine, 3. Piromen in normal and Growth Deficient Children (1967) (0)
- Acknowledgement of reviewers 2013 (2014) (0)
- Evidence for possible precursors in the synthesis of growth hormone by rat and human fetal anterior pituitary in vitro. (1973) (0)
- Familial acromegaly the role of the AIP gene (2007) (0)
- Regulation of growth hormone and insuline-like growth factor I secretion: Discussion session 4 (1990) (0)
- Do Cell Cycle Inhibitors Promote Angiogenesis by Altering the Bone Marrow Microenvironment? (2005) (0)
- Pulsatile Secretion of Growth Hormone (GH) Persists During Continuous Stimulation by CJC-1295, a Long-Acting GHRH Analog (2006) (0)
- Scintigraphic Thyroid Abnormalities after Radiation (2020) (0)
- Experimental and Clinical Models of GHRH-lnduced Pituitary Tumors (1996) (0)
- Regulation of Pituitary Cells (1998) (0)
- Combined Cushing's syndrome and acromegaly due to ectopic production of adrenocorticotropic hormone and growth hormone-releasing hormone (2000) (0)
- Another Indication for Screening and Early Intervention: Problem Drinking (2017) (0)
- Subject Index Vol. 71, Suppl. 1, 2009 (2009) (0)
- Subject Index Vol. 6, 1970 (1970) (0)
- Book ReviewClinical Neuroendocrinology: A pathophysiological approach (1980) (0)
- Contents Vol. 81, 2005 (2005) (0)
- Growth hormone releasing factor analogs with modifications at position 2 and position 19: Effects on growth hormone releasing activity (1994) (0)
- Mishaps with Rat Poison (1964) (0)
- Thiocyanate intoxication. (1963) (0)
- Growth hormone physiology in health and disease: insights using genetic and transgenic models. (1996) (0)
- Contents, Vol. 6, 1970 (1970) (0)
- Pituitary tumors: Back to basics (2003) (0)
- Radiation and Leukaemia (1959) (0)
- More Transplanted Kidneys (1964) (0)
- The clinical and genetic characteristics of patients with familial isolated pituitary adenoma (2009) (0)
- Physiology of the Growth Hormone Releasing Hormone-Somatostatin-Growth Hormone-Insulin-Like Growth Factor I Axis (1995) (0)
- Subject Index Vol. 57, 1993 (1993) (0)
- ISOLATEDFAMILIALSOMATOTROPINOMAS: CLINICALAND GENETICCONSIDERATIONS (2003) (0)
- THE ENDOCRINE FUNCTION OF THE PANCREAS1,2 (1969) (0)
- Subject Index Vol. 81, 2005 (2005) (0)
- 27 Growth Hormone-Releasing Factor (1986) (0)
- Lubrication of Joints (1964) (0)
- Response : Hypothalamic Stimulation of Growth Hormone Secretion (1969) (0)
- Editorial Board (2010) (0)
- AIP and familial acromegaly (2007) (0)
- New Insights in the Study of Growth Gained from the Use of Genetic and Transgenic Models (1999) (0)
- AIP, a Protein Mutated in Familial Acromegaly, Plays a Role in the Regulation of Cell Proliferation and Shows Cell-Type Specific Subcellular Localisation (2008) (0)
- Pancreatic somatostatin-like immunoreactivity (sli) in obese (ob) and diabetic (db) mutant mice: a longitudinal study. Abstr. (1979) (0)
- Hypothalamic Hamartomas and Gangliocytomas (2009) (0)
- Immunocytochemical Localization of TRH in the Rat Spinal Cord (1987) (0)
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