Louis B. Hersh

Louis B. Hersh's AcademicInfluence.com Rankings

Louis B. Hersh

Medical

#2274

World Rank

#2685

Historical Rank

Nutrition

#85

World Rank

#91

Historical Rank

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Medical

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Louis B. Hersh's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice (2005) (828)
Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation* (1998) (816)
Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice (2003) (371)
Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons (1989) (293)
Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo (2003) (287)
Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides. (1983) (285)
Two new proteases in the MHC class I processing pathway (2000) (283)
The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase). (1990) (253)
An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex (1989) (244)
Effects of Estrogen Replacement on the Relative Levels of Choline Acetyltransferase, trkA, and Nerve Growth Factor Messenger RNAs in the Basal Forebrain and Hippocampal Formation of Adult Rats (1994) (243)
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease (1999) (241)
Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons (1989) (235)
Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease (1993) (216)
Immunoaffinity Purification of Human Choline Acetyltransferase: Comparison of the Brain and Placental Enzymes (1985) (207)
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. (1991) (198)
Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. (1989) (194)
Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study (1992) (188)
Choline Acetyltransferase: Celebrating Its Fiftieth Year (1994) (158)
Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus (1992) (155)
Distribution of choline acetyltransferase-containing neurons of the hypothalamus (1987) (152)
Puromycin-sensitive Aminopeptidase (1995) (151)
Prefrontal cortical projections to the cholinergic neurons in the basal forebrain (1991) (142)
Distribution of choline acetyltransferase immunopositive structures in the rat brainstem (1989) (139)
Patterns of direct projections from the hippocampus to the medial septum-diagonal band complex: Anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunohistochemistry of choline acetyltransferase (1991) (137)
Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia (1999) (131)
Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline cleaving enzyme from bovine brain (1980) (121)
An Aminopeptidase from Bovine Brain Which Catalyzes the Hydrolysis of Enkephalin (1981) (121)
Insulysin Hydrolyzes Amyloid β Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques (2000) (120)
Protein Kinase A Regulates Cholinergic Gene Expression in PC12 Cells: REST4 Silences the Silencing Activity of Neuron-Restrictive Silencer Factor/REST (1999) (120)
Neprilysin and amyloid beta peptide degradation. (2008) (116)
Substrate Activation of Insulin-degrading Enzyme (Insulysin) (2003) (114)
Response of septal cholinergic neurons to axotomy (1987) (111)
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes (2011) (111)
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients (1989) (107)
Human striatum: Chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease (1994) (107)
Expression of choline acetyltransferase and nerve growth factor receptor within hypoglossal motoneurons following nerve injury (1991) (103)
Solubilization and characterization of two rat brain membrane-bound aminopeptidases active on Met-enkephalin. (1981) (103)
Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase (1985) (99)
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration. (1991) (98)
Enzymes involved in the degradation of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) in bovine brain (1979) (98)
Quantification of cholinergic and select non-cholinergic mesopontine neuronal populations in the human brain (1999) (96)
Mesencephalic cholinergic nuclei in progressive supranuclear palsy (1991) (95)
Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral. (2005) (92)
Neprilysin regulates amyloid Beta peptide levels. (2004) (87)
Decreased Catalytic Activity of the Insulin-degrading Enzyme in Chromosome 10-Linked Alzheimer Disease Families* (2007) (86)
Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease (1988) (86)
Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease. (1989) (85)
Neprilysin regulates amyloid β peptide levels (2007) (85)
Characterization of Membrane‐Bound Aminopeptidases from Rat Brain: Identification of the Enkephalin‐Degrading Aminopeptidase (1985) (82)
Development of cholinergic neurons in the septal/diagonal band complex of the rat. (1987) (82)
Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium. (1991) (80)
Immunohistochemical localization of aminopeptidase M in rat brain and periphery: Relationship of enzyme localization and enkephalin metabolism (1987) (79)
Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin. (1986) (78)
Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized fisher 344 rats (1993) (78)
Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease (2009) (77)
Synaptic organization of cholinergic amacrine cells in the rhesus monkey retina (1988) (74)
Synaptic connections of starburst amacrine cells and localization of acetylcholine receptors in primate retinas (2003) (74)
Identification of γ-Endorphin-Generating Enzyme as Insulin-Degrading Enzyme† (1996) (73)
Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease (2009) (72)
Identification and characterization of two androgen response regions in the human neutral endopeptidase gene (2000) (71)
Rat liver ι-amidase. Purification and properties (1971) (70)
Studies on the Tissue Distribution of the Puromycin‐Sensitive Enkephalin‐Degrading Aminopeptidases (1988) (70)
Cholinergic innervation in the human hippocampal formation including the entorhinal cortex (1994) (69)
Choline acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer's disease (1989) (69)
Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa. (1991) (68)
Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum (1989) (66)
Cholinergic innervation displays strikingly different laminar preferences in several cortical areas (1986) (66)
Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. (2009) (66)
Circulating neprilysin clears brain amyloid (2010) (65)
Comparison of the Soluble and Membrane‐Bound Forms of the Puromycin‐Sensitive Enkephalin‐Degrading Aminopeptidases from Rat (1990) (64)
Vestibular and cochlear efferent neurons in the monkey identified by immunocytochemical methods (1987) (64)
Reaction of Opioid Peptides with Neutral Endopeptidase (‘Enkephalinase”) (1984) (63)
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. (2005) (63)
Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia (2014) (62)
Cholinergic Neuron‐Specific Expression of the Human Choline Acetyltransferase Gene Is Controlled by Silencer Elements (1993) (62)
Relation of pontine choline acetyltransferase immunoreactive neurons with cells which increase discharge during REM sleep (1987) (61)
ATP Effects on Insulin-degrading Enzyme Are Mediated Primarily through Its Triphosphate Moiety* (2004) (61)
Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders (2004) (59)
Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain (1986) (58)
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. (2009) (57)
Coenzyme A Transferase KINETICS AND EXCHANGE REACTIONS (1967) (57)
Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase. (1990) (57)
Radioimmunoassay of creatine kinase-B isoenzyme in human sera: results in patients with acute myocardial infarction. (1977) (56)
REST/NRSF-Interacting LIM Domain Protein, a Putative Nuclear Translocation Receptor (2003) (56)
Co-localization of choline acetyltransferase and tyrosine hydroxylase within neurons of the dorsal motor nucleus of the vagus. (1990) (55)
Estrogen regulates neprilysin activity in rat brain (2004) (54)
BACE2 expression increases in human neurodegenerative disease. (2012) (54)
Localization of choline acetyltransferase in perikarya and dendrites within the nuclei of the solitary tracts (1988) (54)
The insulysin (insulin degrading enzyme) enigma (2006) (53)
Cholinergic innervation of the human cerebellum (1993) (51)
Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice (1997) (50)
CHOLINERGIC INNERVATION IN THE HUMAN STRIATUM: A THREE-COMPARTMENT MODEL (1996) (50)
Characterization of the REST/NRSF‐interacting LIM domain protein (RILP): localization and interaction with REST/NRSF (2006) (49)
Evidence for the existence of substance P in the prepubertal rat ovary. I. Biochemical and physiologic studies. (1985) (49)
Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of Alzheimer's Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats. (2016) (49)
The basal forebrain cholinergic system: efferent and afferent connectivity and long‐term effects of lesions (1991) (48)
Cloning a rat meprin cDNA reveals the enzyme is a heterodimer. (1992) (48)
Demonstration and nature of endothelin-3-like immunoreactivity in somatostatin and choline acetyltransferase-immunoreactive nerve cells of the neostriatum of the rat (1991) (48)
Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element. (2000) (47)
Immunoreactive Calcitonin Gene‐Related Peptide, Vasoactive Intestinal Polypeptide, and Somatostatin in Developing Chicken Spinal Cord Motoneurons (1989) (47)
The Cholinergic Gene Locus Is Coordinately Regulated by Protein Kinase A II in PC12 Cells (1998) (47)
Degradation of Dynorphin‐Related Peptides by the Puromycin‐Sensitive Aminopeptidase and Aminopeptidase M (1995) (46)
Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease (1992) (46)
A FLUOROMETRIC ASSAY FOR CHOLINE ACETYLTRANSFERASE and ITS USE IN THE PURIFICATION OF THE ENZYME FROM HUMAN PLACENTA (1978) (45)
Mutational Analysis of Aspartate Residues in the Transmembrane Regions and Cytoplasmic Loops of Rat Vesicular Acetylcholine Transporter* (1999) (45)
Tat peptides inhibit neprilysin (2011) (44)
Catalase-coupled gold nanoparticles: comparison between the carbodiimide and biotin-streptavidin methods. (2011) (44)
Use of 5-deazaFAD to study hydrogen transfer in the D-amino acid oxidase reaction. (1975) (43)
Re-evaluation of the kinetic mechanism of the choline acetyltransferase reaction. (1977) (43)
The Vesicular Acetylcholine Transporter Interacts with Clathrin-associated Adaptor Complexes AP-1 and AP-2* (2004) (42)
Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF). (2004) (41)
Cleavage of endorphins to des-Tyr endorphins by homogeneous bovine brain aminopeptidase (1980) (41)
Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant. (1989) (41)
Multiple isoelectric and molecular weight variants of choline acetyltransferase. Artifact or real? (1984) (40)
Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease. (1997) (40)
N-Methylglutamate synthetase. Substrate-flavin hydrogen transfer reactions probed with deazaflavin mononucleotide. (1975) (38)
Functional Analysis of Conserved Histidines in Choline Acetyltransferase by Site‐Directed Mutagenesis (1993) (38)
Regulation of amyloid β-peptide levels by enzymatic degradation (2002) (38)
Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. (2011) (37)
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation. (1994) (37)
Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. (2003) (37)
Identification of an Active Site Arginine in Rat Choline Acetyltransferase by Alanine Scanning Mutagenesis (*) (1995) (36)
Comparisons of the immunocytochemical localization of choline acetyltransferase in the vestibular nuclei of the monkey and rat (1987) (35)
Effect of vitamin B12 deprivation on the in vivo levels of coenzyme A intermediates associated with propionate metabolism. (1974) (35)
Kinetic studies of the choline acetyltransferase reaction using isotope exchange at equilibrium. (1982) (35)
Analysis of the Subsite Specificity of Rat Insulysin Using Fluorogenic Peptide Substrates* (2001) (35)
Identification of the Allosteric Regulatory Site of Insulysin (2011) (35)
EFFECT OF SALTS ON THE PHYSICAL AND KINETIC PROPERTIES OF HUMAN PLACENTAL CHOLINE ACETYLTRANSFERASE (1978) (35)
Selective age-related loss of CALBINDIN-D28k from basal forebrain cholinergic neurons in the common marmoset (callithrix jacchus) (2003) (34)
Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin. (2015) (34)
Reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase in Pseudomonas MA: potential regulation between carbon assimilation and energy production (1975) (34)
Comparison of the Promoter Region of the Human and Porcine Choline Acetyltransferase Genes: Localization of an Important Enhancer Region (1993) (33)
Mutation of Active Site Residues of Insulin-degrading Enzyme Alters Allosteric Interactions* (2005) (33)
Malate adenosine triphosphate lyase. Separation of the reaction into a malate thiokinase and malyl coenzyme A lyase. (1973) (32)
Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. (1999) (31)
[16] Neprilysin: Assay methods, purification, and characterization (1995) (30)
Morphologic alterations of chohnergic processes in the neocortex of aged rats (1988) (30)
Immunocytochemical features of the vestibular nuclei in the monkey and cat. (1990) (29)
Expression of the Choline Acetyltransferase Gene Depends on Protein Kinase A Activity (1995) (29)
Degradation of islet amyloid polypeptide by neprilysin (2012) (28)
Monoaminergic and Peptidergic Innervation of the Intermedio‐Lateral Horn of the Spinal Cord (1990) (28)
Immunological, Physical, and Chemical Evidence for the Identity of Brain and Kidney Post‐Proline Cleaving Enzyme (1981) (28)
Mesopontine cholinergic and non-cholinergic neurons in schizophrenia (1999) (28)
Effect of sodium chloride on changing the rate-limiting step in the human placental choline acetyltransferase reaction. (1978) (27)
Peptidases, Proteases and Amyloid β-Peptide Catabolism (2003) (27)
Nerve cell clusters in dorsal striatum and nucleus accumbens of the male rat demonstrated by glucocorticoid receptor immunoreactivity. (1990) (27)
Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells. (1994) (27)
A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties (2010) (26)
Inhibition of Aminopeptidase and Acetylcholinesterase by Puromycin and Puromycin Analogs (1981) (26)
In vitro and in vivo degradation of Aβ peptide by peptidases coupled to erythrocytes (2007) (26)
Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme. (1996) (26)
Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin. (2006) (26)
Evidence for an essential histidine in neutral endopeptidase 24.11. (1987) (26)
Use of site-directed mutagenesis to identify valine-573 in the S'1 binding site of rat neutral endopeptidase 24.11 (enkephalinase). (1990) (26)
Insulysin: an allosteric enzyme as a target for Alzheimer's disease. (2005) (26)
Phosphorylation of the Rat Vesicular Acetylcholine Transporter* (2000) (25)
The phosphorylation of choline acetyltransferase (1989) (25)
Anion Activation Site of Insulin-degrading Enzyme* (2011) (25)
Nucleophilic addition reactions of free and enzyme-bound deazaflavin. (1976) (24)
Compartmental ordering of cholinergic innervation in the mediodorsal nucleus of the thalamus in human brain (1990) (24)
The vesicular monoamine transporter 2 contains trafficking signals in both its N‐glycosylation and C‐terminal domains (2007) (24)
Rat liver -amidase. Kinetic evidence for an acyl-enzyme intermediate. (1972) (24)
Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor. (2003) (24)
Preparation, characterization, and coenzymic properties of 5-carba-5-deaza and 1-carba-1-deaza analogs of riboflavin, FMN, and FAD. (1980) (24)
Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury (2016) (24)
Cholinergic neuronal loss in the globus pallidus of Alzheimer disease patients (1991) (23)
Neprilysin: assay methods, purification, and characterization. (1995) (23)
Evidence for the existence of a population of arcuate neurons costoring choline acetyltransferase and tyrosine hydroxylase immunoreactivities in the male rat (1989) (23)
Mammalian pitrilysin: substrate specificity and mitochondrial targeting. (2009) (23)
Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide (2002) (23)
Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma (2000) (23)
The reaction of choline acetyltransferase with sulfhydryl reagents. Methoxycarbonyl-CoA disulfide as an active site-directed reagent. (1979) (22)
Coenzyme A Transferase ISOLATION AND PROPERTIES OF AN ENZYME-COENZYME A INTERMEDIATE (1967) (22)
Degradation of enkephalins: the search for an enkephalinase (1982) (22)
Analysis of the importance of arginine 102 in neutral endopeptidase (enkephalinase) catalysis. (1992) (22)
Comparison of the structure and expression of the human and rat neprilysin (endopeptidase 24.11)-encoding genes. (1995) (22)
Expression of Endopeptidase‐24.11 (Common Acute Lymphoblastic Leukaemia Antigen CDI0) in the Sciatic Nerve of the Adult Rat After Lesion and During Regeneration (1995) (22)
Interaction of the brain‐specific protein p42IP4/centaurin‐α1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity (2006) (21)
Enhancer containing unusual GC box-like sequences on the human choline acetyltransferase gene. (1993) (21)
Human choline acetyltransferase gene maps to region 10q11-q22.2 by in situ hybridization. (1991) (21)
Exon 16 del: a novel form of human neutral endopeptidase (CALLA). (1992) (21)
Cyto- and Chemoarchitecture of Basal Forebrain Cholinergic Neurons in the Common Marmoset (Callithrix Jacchus) (2000) (21)
N-methylglutamate synthetase. Purification and properties of the enzyme. (1971) (21)
Novel substrates for angiotensin I converting enzyme. (1983) (20)
Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor–Dependent Mechanism (2013) (20)
Nardilysin cleaves peptides at monobasic sites. (2003) (20)
Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice. (2000) (20)
Demonstration of enzymic hydrogen transfer from substrate to a flavine. (1974) (19)
Aminopeptidases do not directly degrade tau protein (2010) (18)
Multiple molecular forms of rat brain enkephalinase. (1982) (18)
New fluorogenic substrates for N-arginine dibasic convertase. (1999) (18)
Insulin-degrading enzyme is not secreted from cultured cells (2018) (18)
Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes (2017) (18)
Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. (2005) (17)
Fast axonal transport of the vesicular acetylcholine transporter (VAChT) in cholinergic neurons in the rat sciatic nerve (1998) (17)
Peptidases, proteases and amyloid beta-peptide catabolism. (2003) (17)
Purification and characterization of a secreted arginine-specific dibasic cleaving enzyme from EL-4 cells. (1995) (17)
An AP-2 binding sequence within exon 1 of human and porcine choline acetyltransferase genes enhances transcription in neural cells (1996) (17)
Nuclear shuttling of the peptidase nardilysin. (2004) (17)
Studies on the Subsite Specificity of Rat Nardilysin (N-Arginine Dibasic Convertase)* (2000) (17)
Human striatal cholinergic neurons in development, aging and Alzheimer's disease (1990) (17)
Studies on the Kinetic Mechanism and Salt Activation of Bovine Brain Choline Acetyltransferase (1980) (16)
Regulation of amyloid beta-peptide levels by enzymatic degradation. (2002) (16)
Inactivation of neuropeptides. (1995) (16)
A cell type-specific silencer in the human choline acetyltransferase gene requiring two distinct and interactive E boxes. (1995) (16)
Reaction of neutral endopeptidase 24.11 (enkephalinase) with arginine reagents. (1986) (16)
Nomenclature for enkephalin degrading peptidases. (1986) (16)
Thrombin-mediated down-regulation of endothelin receptors in mesangial cells coincides with the down-regulation of neutral endopeptidase activity. (1995) (16)
Expression of the acidic stretch of nardilysin as a functional binding domain. (2001) (16)
Choline acetyltransferase immunopositive neurons in the lateral septum (1990) (16)
Regulation of N-arginine dibasic convertase activity by amines: putative role of a novel acidic domain as an amine binding site. (1998) (16)
Nerve growth factor and phorbol esters increase the number of choline acetyltransferase-positive cells in two morphologically distinct classes of basal forebrain neurons in primary cultures. (1989) (15)
Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis (2008) (15)
A secreted peptidase involved in T cell β-endorphin metabolism (1996) (15)
NGF treatment promotes development of basal forebrain tissue grafts in the anterior chamber of the eye (2004) (15)
Kinetics of succinyldithiocholine hydrolysis by serum cholinesterase: comparison to dibucaine and succinylcholine numbers. (1974) (15)
Degradation of α and β neo-endorphin by rat brain membrane peptidases (1985) (14)
Heterologous expression and characterization of recombinant Lactococcus lactis neutral endopeptidase (neprilysin). (1996) (14)
Isolation of an enzyme-coenzyme A intermediate from succinyl coenzyme A-acetoacetate coenzyme A transferase. (1967) (14)
Analysis of conserved residues of the human puromycin-sensitive aminopeptidase (2003) (14)
Active Site Mutations Change the Cleavage Specificity of Neprilysin (2012) (14)
THE LACK OF SPECIFICITY TOWARDS SALTS IN THE ACTIVATION OF CHOLINE ACETYLTRANSFERASE FROM HUMAN PLACENTA (1979) (14)
Mixed Dimers of Insulin-degrading Enzyme Reveal a Cis Activation Mechanism* (2011) (14)
Letter: The formation of a semiquinone form of deazaFAD bound to D-amino acid oxidase. (1976) (14)
Characterization of the promoter region of the rat neprilysin gene. (1998) (14)
Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth (2007) (14)
N-methylglutamate synthetase. The use of flavin mononucleotide in oxidative catalysis. (1973) (13)
Down regulation of kidney neutral endopeptidase mRNA, protein and activity during acute renal failure: Possible mechanism for ischemia-induced acute renal failure in rats? (1999) (13)
Conservation of Amino Acid Sequences Between Human and Porcine Choline Acetyltransferase (1988) (13)
The Use of DNase I Hypersensitivity Site Mapping to Identify Regulatory Regions of the Human Cholinergic Gene Locus (1998) (13)
Methionine enkephalin metabolism by murine macrophage ectopeptidase(s) (1994) (13)
Tat and amyloid: multiple interactions. (2005) (13)
Activation of Rat Choline Acetyltransferase by Limited Proteolysis (*) (1995) (13)
Aminopeptidase activity in human nasal mucosa (1998) (12)
Kinetic and inactivation studies of recombinant Drosophila choline acetyltransferase (1990) (12)
Subcellular localization of nardilysin during mouse oocyte maturation. (2005) (12)
Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells. (2015) (12)
The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells (2015) (12)
An Extended Polyanion Activation Surface in Insulin Degrading Enzyme (2015) (12)
Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice (2018) (12)
Cholinergic function in cultures of mouse spinal cord neurons (1990) (11)
N-bromoacetyl-D-leucylglycine. An affinity label for neutral endopeptidase 24.11. (1990) (11)
Cholinergic divergent projections from rat basal forebrain to the hippocampus and olfactory bulb (1987) (11)
Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase). (1984) (11)
Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies. (2019) (11)
5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action. (1970) (10)
Endopeptidase 24.16B (1995) (10)
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients (1989) (10)
The use of proteolysis to study the structure of nardilysin. (2002) (10)
Crystallization and preliminary analysis of neurolysin. (2000) (10)
Positional effects in the neprilysin (neutral endopeptidase) reaction. (1994) (8)
Rat liver omega-amidase. Purification and properties. (1971) (7)
Glycosylation variants of endopeptidase-24.11 (‘enkephalinase’) (1992) (7)
N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme. (1972) (7)
The effect of aliphatic alcohols and organic solvents on reactions catalyzed by 5-hydroxy-N-methylpyroglutamate synthetase. (1971) (7)
Induction of choline acetyltransferase in the neuroblastoma x glioma cell line NG108-15 (1992) (7)
The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid. (1969) (7)
Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation. (2006) (7)
Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular β-endorphin endopeptidase (IDE/γ-EpGE) (1998) (7)
Malate thiokinase. The reaction mechanism as determined by initial rate studies. (1974) (7)
A novel mammalian high-molecular-weight aminopeptidase. (1997) (7)
Nomenclature and classification of enkephalin degrading peptidases (1986) (7)
Proteolytic cleavage of the puromycin-sensitive aminopeptidase generates a substrate binding domain. (2003) (6)
Transcriptional regulation of the human choline acetyltransferase gene. (1996) (6)
[15] 3-ketoacid CoA-transferase: [EC 2.8.3.5 Succinyl-CoA: 3-oxoacid CoA-transferase] (1969) (6)
Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease (1994) (6)
Kinetic analysis of spermine binding to NRD convertase. (1999) (6)
Malyl coenzyme A lyase. Mechanism of action as deduced by kinetic analysis. (1974) (6)
Expression, Purification, and Characterization of Recombinant Drosophila Choline Acetyltransferase (1993) (5)
5-Hydroxy-N-methylpyroglutamate synthetase. Evidence for an -ketoglutaryl enzyme intermediate from partitioning studies. (1971) (5)
The reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase from Pseudomonas MA. Correlation of allosteric properties with changes in the sedimentation behavior. (1976) (5)
Increased expression of an endopeptidase (γ‐EGE/IDE) hydrolyzing β‐endorphin during differentiation and maturation of bone marrow macrophages (1997) (5)
Substrate-dependent dissociation of malate thiokinase. (1979) (4)
Reaction of neprilysin (neutral endopeptidase) and thermolysin with cyclic peptides. (1995) (4)
Mutational analysis reveals only one catalytic histidine in neutral endopeptidase ("enkephalinase"). (1992) (4)
Cysteine 904 Is Required for Maximal Insulin Degrading Enzyme Activity and Polyanion Activation (2012) (4)
Reaction of malate thiokinase with methoxycarbonyl-CoA disulfide. Evidence for half-of-the-sites reactivity. (1982) (4)
Regulated expression of an endopeptidase that hydrolyses beta-endorphin during differentiation of macrophages and T cells. (1998) (4)
Tissue‐specific Expression of Rat Neutral Endopeptidase mRNAs a (1996) (4)
Studies on detergent released choline acetyltransferase from membrane fractions of rat and human brain (1987) (4)
The reduced nicotinamide adenine nucleotide-activated phosphoenolpyruvate carboxylase from Pseudomonas MA. Further studies on regulatory properties. (1978) (3)
Half-of-the-sites reactivity in the malate thiokinase reaction. (1981) (3)
Effect of electron withdrawing substituents on substrate hydrolysis by and inhibition of rat neutral endopeptidase 24.11 (enkephalinase) and thermolysin. (1990) (3)
[5] N-Methyl-l-glutamate synthase (1985) (3)
Regulation of the cholinergic gene locus (1998) (3)
Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes (2022) (3)
A secreted peptidase involved in T cell beta-endorphin metabolism. (1996) (2)
Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular beta-endorphin endopeptidase (IDE/gamma-EpGE). (1998) (2)
Active β-Endorphin Metabolites Generated by T-Cell Ectopeptidases (1995) (2)
INTRANEURONAL AMYLIN DEPOSITION, PEROXIDATIVE MEMBRANE INJURY AND INCREASED IL-1SS SYNTHESIS IN BRAINS OF ALZHEIMER’S DISEASE PATIENTS WITH TYPE-2 DIABETES AND DIABETIC HIP RATS (2016) (2)
Differential expression of neprilysin ‘enkephalinase’ mRNA transcripts in rat brain (2000) (2)
Immuno-affinity purification of human placental choline acetyltransferase (1984) (2)
Cyclic AMP regulation of the human choline acetyltransferase gene (1993) (2)
Carboxylase inPseudomonas MA: Potential Regulation BetweenCarbonAssimilation and EnergyProduction (1975) (2)
Neuroendocrine and trophic actions of nicotine (1988) (2)
Degradation of alpha and beta neo-endorphin by rat brain membrane peptidases. (1985) (1)
An Allosteric Enzyme As a Target for Alzheimer's Disease (2005) (1)
Hersh LB. N- bromo-acetyl-D-leucylglycine: an affinity label for neutral endopeptidase 24.11 (1990) (1)
Choline acetyltransferase (ChAT)- and VIP-like immunoreactivity in rat lung (1989) (1)
Purification and Characterization of a Secreted T Cell β-Endorphin Endopeptidase (1996) (1)
Regulation of cholinergic gene expression by NRSF/REST (2004) (1)
Mechanism based design of inhibitors of neuropeptide degrading enzymes. (1987) (1)
Toxoplasma gondii Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells (2021) (1)
Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and in patients with Alzheimer's disease (1989) (1)
Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia (2014) (1)
Decreased lung neprilysin gene expression in humans with COPD and pulmonary vascular remodeling (2011) (0)
Purification and characterization of a secreted T cell beta-endorphin endopeptidase. (1996) (0)
STUDIES ON FMN-DEPLETED AND RECONSTITUTED NADPH-CYTOCHROME (P-450) REDUCTASE (1980) (0)
Development and validation of nanobodies specific to the oncogenic phosphatase Protein Tyrosine Phosphatase 4A3 (PTP4A3 or PRL-3) (2020) (0)
Methoxycarbonyl-CoA disulfide: an active site-directed sulfhydryl reagent. (1981) (0)
Regulation of the Choline Acetyltransferase Gene (1992) (0)
NeuropeptideYFragmentsDerivedfromNeprilysin ProcessingAreNeuroprotectiveinaTransgenicModelof Alzheimer'sDisease (2009) (0)
Properties of human placental and brain choline acetyltransferase (1985) (0)
Peripheral expression of neprilysin leads to clearance of brain Abeta (2010) (0)
Specificity of the Rat Vesicular Acetylcholine Transporter (2003) (0)
6-2-2015 Amyloid Peptide Inactivating Enzyme to Treat Alzheimer ' s Disease Peripherally (2017) (0)
Insulin Degrading Enzyme Assays for Treatment of Alzheimer ' s Disease (2017) (0)
149: Lentiviral Vector Neutral Endopeptidase Gene Transfer Suppresses Prostate Cancer Tumor Growth (2007) (0)
Use of site-directed mutagenesis to elucidate the active site of neutral endopeptidase 24.11 (enkephalinase). (1991) (0)
Characterization and substrate specificity of gamma endorphin generating endopeptidase (1994) (0)
Book Review:Catalysis and Enzyme Action. Myron L. Bender, Lewis J. Brubacher (1975) (0)
Abstract 3752: Identification of nanobodies specific for the oncogenic protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) that modulate its binding, stability, and phosphatase activity (2020) (0)
525. Therapy for Alzheimer's disease by neprilysin gene transfer (2004) (0)
P4-091 Mechanisms of neuroprotection mediated by neprilysin in APP-transgenic mice (2006) (0)
96-1 Peptidases as potential targets for drug therapy (1997) (0)
Book Review:Annual Review of Biochemistry. Volume 42. Esmond E. Snell, Paul D. Boyer, Alton Meister, Charles C. Richardson (1975) (0)
O2-05-01 Peripheral expression of neprilysin decreases amyloid deposition in hAPP mice (2006) (0)
Active beta-endorphin metabolites generated by T-cell ectopeptidases. (1995) (0)
Development and characterization of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) (2022) (0)
Demonstration of enzymic hydrogen transfer from substrate to a flavine (1974) (0)
Intravitreally delivered neprilysin reduces amyloid-beta in the mouse eye (2015) (0)
Insulin-degrading enzyme is not secreted from cultured cells (2018) (0)
P2-343: Peripherally overexpessed neprilysin in muscle reduces brain amyloid in a transgenic mouse model of AD (2008) (0)
N-Methyl-L-glutamate synthase. (1985) (0)
The role of charged transmembrane residues of rVAChT on ACh transport and vesamicol binding (1998) (0)

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