Louis B. Hersh
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(Suggest an Edit or Addition)Louis B. Hersh's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice (2005) (828)
- Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation* (1998) (816)
- Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice (2003) (371)
- Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons (1989) (293)
- Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo (2003) (287)
- Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides. (1983) (285)
- Two new proteases in the MHC class I processing pathway (2000) (283)
- The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase). (1990) (253)
- An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex (1989) (244)
- Effects of Estrogen Replacement on the Relative Levels of Choline Acetyltransferase, trkA, and Nerve Growth Factor Messenger RNAs in the Basal Forebrain and Hippocampal Formation of Adult Rats (1994) (243)
- Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease (1999) (241)
- Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: Colocalization with cholinergic neurons (1989) (235)
- Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease (1993) (216)
- Immunoaffinity Purification of Human Choline Acetyltransferase: Comparison of the Brain and Placental Enzymes (1985) (207)
- CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. (1991) (198)
- Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. (1989) (194)
- Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study (1992) (188)
- Choline Acetyltransferase: Celebrating Its Fiftieth Year (1994) (158)
- Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus (1992) (155)
- Distribution of choline acetyltransferase-containing neurons of the hypothalamus (1987) (152)
- Puromycin-sensitive Aminopeptidase (1995) (151)
- Prefrontal cortical projections to the cholinergic neurons in the basal forebrain (1991) (142)
- Distribution of choline acetyltransferase immunopositive structures in the rat brainstem (1989) (139)
- Patterns of direct projections from the hippocampus to the medial septum-diagonal band complex: Anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunohistochemistry of choline acetyltransferase (1991) (137)
- Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia (1999) (131)
- Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline cleaving enzyme from bovine brain (1980) (121)
- An Aminopeptidase from Bovine Brain Which Catalyzes the Hydrolysis of Enkephalin (1981) (121)
- Insulysin Hydrolyzes Amyloid β Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques (2000) (120)
- Protein Kinase A Regulates Cholinergic Gene Expression in PC12 Cells: REST4 Silences the Silencing Activity of Neuron-Restrictive Silencer Factor/REST (1999) (120)
- Neprilysin and amyloid beta peptide degradation. (2008) (116)
- Substrate Activation of Insulin-degrading Enzyme (Insulysin) (2003) (114)
- Response of septal cholinergic neurons to axotomy (1987) (111)
- Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes (2011) (111)
- Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients (1989) (107)
- Human striatum: Chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease (1994) (107)
- Expression of choline acetyltransferase and nerve growth factor receptor within hypoglossal motoneurons following nerve injury (1991) (103)
- Solubilization and characterization of two rat brain membrane-bound aminopeptidases active on Met-enkephalin. (1981) (103)
- Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase (1985) (99)
- Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration. (1991) (98)
- Enzymes involved in the degradation of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) in bovine brain (1979) (98)
- Quantification of cholinergic and select non-cholinergic mesopontine neuronal populations in the human brain (1999) (96)
- Mesencephalic cholinergic nuclei in progressive supranuclear palsy (1991) (95)
- Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral. (2005) (92)
- Neprilysin regulates amyloid Beta peptide levels. (2004) (87)
- Decreased Catalytic Activity of the Insulin-degrading Enzyme in Chromosome 10-Linked Alzheimer Disease Families* (2007) (86)
- Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease (1988) (86)
- Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease. (1989) (85)
- Neprilysin regulates amyloid β peptide levels (2007) (85)
- Characterization of Membrane‐Bound Aminopeptidases from Rat Brain: Identification of the Enkephalin‐Degrading Aminopeptidase (1985) (82)
- Development of cholinergic neurons in the septal/diagonal band complex of the rat. (1987) (82)
- Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium. (1991) (80)
- Immunohistochemical localization of aminopeptidase M in rat brain and periphery: Relationship of enzyme localization and enkephalin metabolism (1987) (79)
- Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin. (1986) (78)
- Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized fisher 344 rats (1993) (78)
- Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease (2009) (77)
- Synaptic organization of cholinergic amacrine cells in the rhesus monkey retina (1988) (74)
- Synaptic connections of starburst amacrine cells and localization of acetylcholine receptors in primate retinas (2003) (74)
- Identification of γ-Endorphin-Generating Enzyme as Insulin-Degrading Enzyme† (1996) (73)
- Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease (2009) (72)
- Identification and characterization of two androgen response regions in the human neutral endopeptidase gene (2000) (71)
- Rat liver ι-amidase. Purification and properties (1971) (70)
- Studies on the Tissue Distribution of the Puromycin‐Sensitive Enkephalin‐Degrading Aminopeptidases (1988) (70)
- Cholinergic innervation in the human hippocampal formation including the entorhinal cortex (1994) (69)
- Choline acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer's disease (1989) (69)
- Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa. (1991) (68)
- Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum (1989) (66)
- Cholinergic innervation displays strikingly different laminar preferences in several cortical areas (1986) (66)
- Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. (2009) (66)
- Circulating neprilysin clears brain amyloid (2010) (65)
- Comparison of the Soluble and Membrane‐Bound Forms of the Puromycin‐Sensitive Enkephalin‐Degrading Aminopeptidases from Rat (1990) (64)
- Vestibular and cochlear efferent neurons in the monkey identified by immunocytochemical methods (1987) (64)
- Reaction of Opioid Peptides with Neutral Endopeptidase (‘Enkephalinase”) (1984) (63)
- Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. (2005) (63)
- Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia (2014) (62)
- Cholinergic Neuron‐Specific Expression of the Human Choline Acetyltransferase Gene Is Controlled by Silencer Elements (1993) (62)
- Relation of pontine choline acetyltransferase immunoreactive neurons with cells which increase discharge during REM sleep (1987) (61)
- ATP Effects on Insulin-degrading Enzyme Are Mediated Primarily through Its Triphosphate Moiety* (2004) (61)
- Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders (2004) (59)
- Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain (1986) (58)
- Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. (2009) (57)
- Coenzyme A Transferase KINETICS AND EXCHANGE REACTIONS (1967) (57)
- Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase. (1990) (57)
- Radioimmunoassay of creatine kinase-B isoenzyme in human sera: results in patients with acute myocardial infarction. (1977) (56)
- REST/NRSF-Interacting LIM Domain Protein, a Putative Nuclear Translocation Receptor (2003) (56)
- Co-localization of choline acetyltransferase and tyrosine hydroxylase within neurons of the dorsal motor nucleus of the vagus. (1990) (55)
- Estrogen regulates neprilysin activity in rat brain (2004) (54)
- BACE2 expression increases in human neurodegenerative disease. (2012) (54)
- Localization of choline acetyltransferase in perikarya and dendrites within the nuclei of the solitary tracts (1988) (54)
- The insulysin (insulin degrading enzyme) enigma (2006) (53)
- Cholinergic innervation of the human cerebellum (1993) (51)
- Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice (1997) (50)
- CHOLINERGIC INNERVATION IN THE HUMAN STRIATUM: A THREE-COMPARTMENT MODEL (1996) (50)
- Characterization of the REST/NRSF‐interacting LIM domain protein (RILP): localization and interaction with REST/NRSF (2006) (49)
- Evidence for the existence of substance P in the prepubertal rat ovary. I. Biochemical and physiologic studies. (1985) (49)
- Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of Alzheimer's Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats. (2016) (49)
- The basal forebrain cholinergic system: efferent and afferent connectivity and long‐term effects of lesions (1991) (48)
- Cloning a rat meprin cDNA reveals the enzyme is a heterodimer. (1992) (48)
- Demonstration and nature of endothelin-3-like immunoreactivity in somatostatin and choline acetyltransferase-immunoreactive nerve cells of the neostriatum of the rat (1991) (48)
- Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element. (2000) (47)
- Immunoreactive Calcitonin Gene‐Related Peptide, Vasoactive Intestinal Polypeptide, and Somatostatin in Developing Chicken Spinal Cord Motoneurons (1989) (47)
- The Cholinergic Gene Locus Is Coordinately Regulated by Protein Kinase A II in PC12 Cells (1998) (47)
- Degradation of Dynorphin‐Related Peptides by the Puromycin‐Sensitive Aminopeptidase and Aminopeptidase M (1995) (46)
- Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease (1992) (46)
- A FLUOROMETRIC ASSAY FOR CHOLINE ACETYLTRANSFERASE and ITS USE IN THE PURIFICATION OF THE ENZYME FROM HUMAN PLACENTA (1978) (45)
- Mutational Analysis of Aspartate Residues in the Transmembrane Regions and Cytoplasmic Loops of Rat Vesicular Acetylcholine Transporter* (1999) (45)
- Tat peptides inhibit neprilysin (2011) (44)
- Catalase-coupled gold nanoparticles: comparison between the carbodiimide and biotin-streptavidin methods. (2011) (44)
- Use of 5-deazaFAD to study hydrogen transfer in the D-amino acid oxidase reaction. (1975) (43)
- Re-evaluation of the kinetic mechanism of the choline acetyltransferase reaction. (1977) (43)
- The Vesicular Acetylcholine Transporter Interacts with Clathrin-associated Adaptor Complexes AP-1 and AP-2* (2004) (42)
- Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF). (2004) (41)
- Cleavage of endorphins to des-Tyr endorphins by homogeneous bovine brain aminopeptidase (1980) (41)
- Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant. (1989) (41)
- Multiple isoelectric and molecular weight variants of choline acetyltransferase. Artifact or real? (1984) (40)
- Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease. (1997) (40)
- N-Methylglutamate synthetase. Substrate-flavin hydrogen transfer reactions probed with deazaflavin mononucleotide. (1975) (38)
- Functional Analysis of Conserved Histidines in Choline Acetyltransferase by Site‐Directed Mutagenesis (1993) (38)
- Regulation of amyloid β-peptide levels by enzymatic degradation (2002) (38)
- Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. (2011) (37)
- Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation. (1994) (37)
- Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. (2003) (37)
- Identification of an Active Site Arginine in Rat Choline Acetyltransferase by Alanine Scanning Mutagenesis (*) (1995) (36)
- Comparisons of the immunocytochemical localization of choline acetyltransferase in the vestibular nuclei of the monkey and rat (1987) (35)
- Effect of vitamin B12 deprivation on the in vivo levels of coenzyme A intermediates associated with propionate metabolism. (1974) (35)
- Kinetic studies of the choline acetyltransferase reaction using isotope exchange at equilibrium. (1982) (35)
- Analysis of the Subsite Specificity of Rat Insulysin Using Fluorogenic Peptide Substrates* (2001) (35)
- Identification of the Allosteric Regulatory Site of Insulysin (2011) (35)
- EFFECT OF SALTS ON THE PHYSICAL AND KINETIC PROPERTIES OF HUMAN PLACENTAL CHOLINE ACETYLTRANSFERASE (1978) (35)
- Selective age-related loss of CALBINDIN-D28k from basal forebrain cholinergic neurons in the common marmoset (callithrix jacchus) (2003) (34)
- Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin. (2015) (34)
- Reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase in Pseudomonas MA: potential regulation between carbon assimilation and energy production (1975) (34)
- Comparison of the Promoter Region of the Human and Porcine Choline Acetyltransferase Genes: Localization of an Important Enhancer Region (1993) (33)
- Mutation of Active Site Residues of Insulin-degrading Enzyme Alters Allosteric Interactions* (2005) (33)
- Malate adenosine triphosphate lyase. Separation of the reaction into a malate thiokinase and malyl coenzyme A lyase. (1973) (32)
- Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. (1999) (31)
- [16] Neprilysin: Assay methods, purification, and characterization (1995) (30)
- Morphologic alterations of chohnergic processes in the neocortex of aged rats (1988) (30)
- Immunocytochemical features of the vestibular nuclei in the monkey and cat. (1990) (29)
- Expression of the Choline Acetyltransferase Gene Depends on Protein Kinase A Activity (1995) (29)
- Degradation of islet amyloid polypeptide by neprilysin (2012) (28)
- Monoaminergic and Peptidergic Innervation of the Intermedio‐Lateral Horn of the Spinal Cord (1990) (28)
- Immunological, Physical, and Chemical Evidence for the Identity of Brain and Kidney Post‐Proline Cleaving Enzyme (1981) (28)
- Mesopontine cholinergic and non-cholinergic neurons in schizophrenia (1999) (28)
- Effect of sodium chloride on changing the rate-limiting step in the human placental choline acetyltransferase reaction. (1978) (27)
- Peptidases, Proteases and Amyloid β-Peptide Catabolism (2003) (27)
- Nerve cell clusters in dorsal striatum and nucleus accumbens of the male rat demonstrated by glucocorticoid receptor immunoreactivity. (1990) (27)
- Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells. (1994) (27)
- A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties (2010) (26)
- Inhibition of Aminopeptidase and Acetylcholinesterase by Puromycin and Puromycin Analogs (1981) (26)
- In vitro and in vivo degradation of Aβ peptide by peptidases coupled to erythrocytes (2007) (26)
- Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme. (1996) (26)
- Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin. (2006) (26)
- Evidence for an essential histidine in neutral endopeptidase 24.11. (1987) (26)
- Use of site-directed mutagenesis to identify valine-573 in the S'1 binding site of rat neutral endopeptidase 24.11 (enkephalinase). (1990) (26)
- Insulysin: an allosteric enzyme as a target for Alzheimer's disease. (2005) (26)
- Phosphorylation of the Rat Vesicular Acetylcholine Transporter* (2000) (25)
- The phosphorylation of choline acetyltransferase (1989) (25)
- Anion Activation Site of Insulin-degrading Enzyme* (2011) (25)
- Nucleophilic addition reactions of free and enzyme-bound deazaflavin. (1976) (24)
- Compartmental ordering of cholinergic innervation in the mediodorsal nucleus of the thalamus in human brain (1990) (24)
- The vesicular monoamine transporter 2 contains trafficking signals in both its N‐glycosylation and C‐terminal domains (2007) (24)
- Rat liver -amidase. Kinetic evidence for an acyl-enzyme intermediate. (1972) (24)
- Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor. (2003) (24)
- Preparation, characterization, and coenzymic properties of 5-carba-5-deaza and 1-carba-1-deaza analogs of riboflavin, FMN, and FAD. (1980) (24)
- Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury (2016) (24)
- Cholinergic neuronal loss in the globus pallidus of Alzheimer disease patients (1991) (23)
- Neprilysin: assay methods, purification, and characterization. (1995) (23)
- Evidence for the existence of a population of arcuate neurons costoring choline acetyltransferase and tyrosine hydroxylase immunoreactivities in the male rat (1989) (23)
- Mammalian pitrilysin: substrate specificity and mitochondrial targeting. (2009) (23)
- Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide (2002) (23)
- Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma (2000) (23)
- The reaction of choline acetyltransferase with sulfhydryl reagents. Methoxycarbonyl-CoA disulfide as an active site-directed reagent. (1979) (22)
- Coenzyme A Transferase ISOLATION AND PROPERTIES OF AN ENZYME-COENZYME A INTERMEDIATE (1967) (22)
- Degradation of enkephalins: the search for an enkephalinase (1982) (22)
- Analysis of the importance of arginine 102 in neutral endopeptidase (enkephalinase) catalysis. (1992) (22)
- Comparison of the structure and expression of the human and rat neprilysin (endopeptidase 24.11)-encoding genes. (1995) (22)
- Expression of Endopeptidase‐24.11 (Common Acute Lymphoblastic Leukaemia Antigen CDI0) in the Sciatic Nerve of the Adult Rat After Lesion and During Regeneration (1995) (22)
- Interaction of the brain‐specific protein p42IP4/centaurin‐α1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity (2006) (21)
- Enhancer containing unusual GC box-like sequences on the human choline acetyltransferase gene. (1993) (21)
- Human choline acetyltransferase gene maps to region 10q11-q22.2 by in situ hybridization. (1991) (21)
- Exon 16 del: a novel form of human neutral endopeptidase (CALLA). (1992) (21)
- Cyto- and Chemoarchitecture of Basal Forebrain Cholinergic Neurons in the Common Marmoset (Callithrix Jacchus) (2000) (21)
- N-methylglutamate synthetase. Purification and properties of the enzyme. (1971) (21)
- Novel substrates for angiotensin I converting enzyme. (1983) (20)
- Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor–Dependent Mechanism (2013) (20)
- Nardilysin cleaves peptides at monobasic sites. (2003) (20)
- Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice. (2000) (20)
- Demonstration of enzymic hydrogen transfer from substrate to a flavine. (1974) (19)
- Aminopeptidases do not directly degrade tau protein (2010) (18)
- Multiple molecular forms of rat brain enkephalinase. (1982) (18)
- New fluorogenic substrates for N-arginine dibasic convertase. (1999) (18)
- Insulin-degrading enzyme is not secreted from cultured cells (2018) (18)
- Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes (2017) (18)
- Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. (2005) (17)
- Fast axonal transport of the vesicular acetylcholine transporter (VAChT) in cholinergic neurons in the rat sciatic nerve (1998) (17)
- Peptidases, proteases and amyloid beta-peptide catabolism. (2003) (17)
- Purification and characterization of a secreted arginine-specific dibasic cleaving enzyme from EL-4 cells. (1995) (17)
- An AP-2 binding sequence within exon 1 of human and porcine choline acetyltransferase genes enhances transcription in neural cells (1996) (17)
- Nuclear shuttling of the peptidase nardilysin. (2004) (17)
- Studies on the Subsite Specificity of Rat Nardilysin (N-Arginine Dibasic Convertase)* (2000) (17)
- Human striatal cholinergic neurons in development, aging and Alzheimer's disease (1990) (17)
- Studies on the Kinetic Mechanism and Salt Activation of Bovine Brain Choline Acetyltransferase (1980) (16)
- Regulation of amyloid beta-peptide levels by enzymatic degradation. (2002) (16)
- Inactivation of neuropeptides. (1995) (16)
- A cell type-specific silencer in the human choline acetyltransferase gene requiring two distinct and interactive E boxes. (1995) (16)
- Reaction of neutral endopeptidase 24.11 (enkephalinase) with arginine reagents. (1986) (16)
- Nomenclature for enkephalin degrading peptidases. (1986) (16)
- Thrombin-mediated down-regulation of endothelin receptors in mesangial cells coincides with the down-regulation of neutral endopeptidase activity. (1995) (16)
- Expression of the acidic stretch of nardilysin as a functional binding domain. (2001) (16)
- Choline acetyltransferase immunopositive neurons in the lateral septum (1990) (16)
- Regulation of N-arginine dibasic convertase activity by amines: putative role of a novel acidic domain as an amine binding site. (1998) (16)
- Nerve growth factor and phorbol esters increase the number of choline acetyltransferase-positive cells in two morphologically distinct classes of basal forebrain neurons in primary cultures. (1989) (15)
- Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis (2008) (15)
- A secreted peptidase involved in T cell β-endorphin metabolism (1996) (15)
- NGF treatment promotes development of basal forebrain tissue grafts in the anterior chamber of the eye (2004) (15)
- Kinetics of succinyldithiocholine hydrolysis by serum cholinesterase: comparison to dibucaine and succinylcholine numbers. (1974) (15)
- Degradation of α and β neo-endorphin by rat brain membrane peptidases (1985) (14)
- Heterologous expression and characterization of recombinant Lactococcus lactis neutral endopeptidase (neprilysin). (1996) (14)
- Isolation of an enzyme-coenzyme A intermediate from succinyl coenzyme A-acetoacetate coenzyme A transferase. (1967) (14)
- Analysis of conserved residues of the human puromycin-sensitive aminopeptidase (2003) (14)
- Active Site Mutations Change the Cleavage Specificity of Neprilysin (2012) (14)
- THE LACK OF SPECIFICITY TOWARDS SALTS IN THE ACTIVATION OF CHOLINE ACETYLTRANSFERASE FROM HUMAN PLACENTA (1979) (14)
- Mixed Dimers of Insulin-degrading Enzyme Reveal a Cis Activation Mechanism* (2011) (14)
- Letter: The formation of a semiquinone form of deazaFAD bound to D-amino acid oxidase. (1976) (14)
- Characterization of the promoter region of the rat neprilysin gene. (1998) (14)
- Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth (2007) (14)
- N-methylglutamate synthetase. The use of flavin mononucleotide in oxidative catalysis. (1973) (13)
- Down regulation of kidney neutral endopeptidase mRNA, protein and activity during acute renal failure: Possible mechanism for ischemia-induced acute renal failure in rats? (1999) (13)
- Conservation of Amino Acid Sequences Between Human and Porcine Choline Acetyltransferase (1988) (13)
- The Use of DNase I Hypersensitivity Site Mapping to Identify Regulatory Regions of the Human Cholinergic Gene Locus (1998) (13)
- Methionine enkephalin metabolism by murine macrophage ectopeptidase(s) (1994) (13)
- Tat and amyloid: multiple interactions. (2005) (13)
- Activation of Rat Choline Acetyltransferase by Limited Proteolysis (*) (1995) (13)
- Aminopeptidase activity in human nasal mucosa (1998) (12)
- Kinetic and inactivation studies of recombinant Drosophila choline acetyltransferase (1990) (12)
- Subcellular localization of nardilysin during mouse oocyte maturation. (2005) (12)
- Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells. (2015) (12)
- The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells (2015) (12)
- An Extended Polyanion Activation Surface in Insulin Degrading Enzyme (2015) (12)
- Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice (2018) (12)
- Cholinergic function in cultures of mouse spinal cord neurons (1990) (11)
- N-bromoacetyl-D-leucylglycine. An affinity label for neutral endopeptidase 24.11. (1990) (11)
- Cholinergic divergent projections from rat basal forebrain to the hippocampus and olfactory bulb (1987) (11)
- Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase). (1984) (11)
- Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies. (2019) (11)
- 5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action. (1970) (10)
- Endopeptidase 24.16B (1995) (10)
- Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients (1989) (10)
- The use of proteolysis to study the structure of nardilysin. (2002) (10)
- Crystallization and preliminary analysis of neurolysin. (2000) (10)
- Positional effects in the neprilysin (neutral endopeptidase) reaction. (1994) (8)
- Rat liver omega-amidase. Purification and properties. (1971) (7)
- Glycosylation variants of endopeptidase-24.11 (‘enkephalinase’) (1992) (7)
- N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme. (1972) (7)
- The effect of aliphatic alcohols and organic solvents on reactions catalyzed by 5-hydroxy-N-methylpyroglutamate synthetase. (1971) (7)
- Induction of choline acetyltransferase in the neuroblastoma x glioma cell line NG108-15 (1992) (7)
- The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid. (1969) (7)
- Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation. (2006) (7)
- Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular β-endorphin endopeptidase (IDE/γ-EpGE) (1998) (7)
- Malate thiokinase. The reaction mechanism as determined by initial rate studies. (1974) (7)
- A novel mammalian high-molecular-weight aminopeptidase. (1997) (7)
- Nomenclature and classification of enkephalin degrading peptidases (1986) (7)
- Proteolytic cleavage of the puromycin-sensitive aminopeptidase generates a substrate binding domain. (2003) (6)
- Transcriptional regulation of the human choline acetyltransferase gene. (1996) (6)
- [15] 3-ketoacid CoA-transferase: [EC 2.8.3.5 Succinyl-CoA: 3-oxoacid CoA-transferase] (1969) (6)
- Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease (1994) (6)
- Kinetic analysis of spermine binding to NRD convertase. (1999) (6)
- Malyl coenzyme A lyase. Mechanism of action as deduced by kinetic analysis. (1974) (6)
- Expression, Purification, and Characterization of Recombinant Drosophila Choline Acetyltransferase (1993) (5)
- 5-Hydroxy-N-methylpyroglutamate synthetase. Evidence for an -ketoglutaryl enzyme intermediate from partitioning studies. (1971) (5)
- The reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase from Pseudomonas MA. Correlation of allosteric properties with changes in the sedimentation behavior. (1976) (5)
- Increased expression of an endopeptidase (γ‐EGE/IDE) hydrolyzing β‐endorphin during differentiation and maturation of bone marrow macrophages (1997) (5)
- Substrate-dependent dissociation of malate thiokinase. (1979) (4)
- Reaction of neprilysin (neutral endopeptidase) and thermolysin with cyclic peptides. (1995) (4)
- Mutational analysis reveals only one catalytic histidine in neutral endopeptidase ("enkephalinase"). (1992) (4)
- Cysteine 904 Is Required for Maximal Insulin Degrading Enzyme Activity and Polyanion Activation (2012) (4)
- Reaction of malate thiokinase with methoxycarbonyl-CoA disulfide. Evidence for half-of-the-sites reactivity. (1982) (4)
- Regulated expression of an endopeptidase that hydrolyses beta-endorphin during differentiation of macrophages and T cells. (1998) (4)
- Tissue‐specific Expression of Rat Neutral Endopeptidase mRNAs a (1996) (4)
- Studies on detergent released choline acetyltransferase from membrane fractions of rat and human brain (1987) (4)
- The reduced nicotinamide adenine nucleotide-activated phosphoenolpyruvate carboxylase from Pseudomonas MA. Further studies on regulatory properties. (1978) (3)
- Half-of-the-sites reactivity in the malate thiokinase reaction. (1981) (3)
- Effect of electron withdrawing substituents on substrate hydrolysis by and inhibition of rat neutral endopeptidase 24.11 (enkephalinase) and thermolysin. (1990) (3)
- [5] N-Methyl-l-glutamate synthase (1985) (3)
- Regulation of the cholinergic gene locus (1998) (3)
- Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes (2022) (3)
- A secreted peptidase involved in T cell beta-endorphin metabolism. (1996) (2)
- Anti-CD3 activation of human CD4+ T cells increases expression of the intracellular beta-endorphin endopeptidase (IDE/gamma-EpGE). (1998) (2)
- Active β-Endorphin Metabolites Generated by T-Cell Ectopeptidases (1995) (2)
- INTRANEURONAL AMYLIN DEPOSITION, PEROXIDATIVE MEMBRANE INJURY AND INCREASED IL-1SS SYNTHESIS IN BRAINS OF ALZHEIMER’S DISEASE PATIENTS WITH TYPE-2 DIABETES AND DIABETIC HIP RATS (2016) (2)
- Differential expression of neprilysin ‘enkephalinase’ mRNA transcripts in rat brain (2000) (2)
- Immuno-affinity purification of human placental choline acetyltransferase (1984) (2)
- Cyclic AMP regulation of the human choline acetyltransferase gene (1993) (2)
- Carboxylase inPseudomonas MA: Potential Regulation BetweenCarbonAssimilation and EnergyProduction (1975) (2)
- Neuroendocrine and trophic actions of nicotine (1988) (2)
- Degradation of alpha and beta neo-endorphin by rat brain membrane peptidases. (1985) (1)
- An Allosteric Enzyme As a Target for Alzheimer's Disease (2005) (1)
- Hersh LB. N- bromo-acetyl-D-leucylglycine: an affinity label for neutral endopeptidase 24.11 (1990) (1)
- Choline acetyltransferase (ChAT)- and VIP-like immunoreactivity in rat lung (1989) (1)
- Purification and Characterization of a Secreted T Cell β-Endorphin Endopeptidase (1996) (1)
- Regulation of cholinergic gene expression by NRSF/REST (2004) (1)
- Mechanism based design of inhibitors of neuropeptide degrading enzymes. (1987) (1)
- Toxoplasma gondii Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells (2021) (1)
- Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and in patients with Alzheimer's disease (1989) (1)
- Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia (2014) (1)
- Decreased lung neprilysin gene expression in humans with COPD and pulmonary vascular remodeling (2011) (0)
- Purification and characterization of a secreted T cell beta-endorphin endopeptidase. (1996) (0)
- STUDIES ON FMN-DEPLETED AND RECONSTITUTED NADPH-CYTOCHROME (P-450) REDUCTASE (1980) (0)
- Development and validation of nanobodies specific to the oncogenic phosphatase Protein Tyrosine Phosphatase 4A3 (PTP4A3 or PRL-3) (2020) (0)
- Methoxycarbonyl-CoA disulfide: an active site-directed sulfhydryl reagent. (1981) (0)
- Regulation of the Choline Acetyltransferase Gene (1992) (0)
- NeuropeptideYFragmentsDerivedfromNeprilysin ProcessingAreNeuroprotectiveinaTransgenicModelof Alzheimer'sDisease (2009) (0)
- Properties of human placental and brain choline acetyltransferase (1985) (0)
- Peripheral expression of neprilysin leads to clearance of brain Abeta (2010) (0)
- Specificity of the Rat Vesicular Acetylcholine Transporter (2003) (0)
- 6-2-2015 Amyloid Peptide Inactivating Enzyme to Treat Alzheimer ' s Disease Peripherally (2017) (0)
- Insulin Degrading Enzyme Assays for Treatment of Alzheimer ' s Disease (2017) (0)
- 149: Lentiviral Vector Neutral Endopeptidase Gene Transfer Suppresses Prostate Cancer Tumor Growth (2007) (0)
- Use of site-directed mutagenesis to elucidate the active site of neutral endopeptidase 24.11 (enkephalinase). (1991) (0)
- Characterization and substrate specificity of gamma endorphin generating endopeptidase (1994) (0)
- Book Review:Catalysis and Enzyme Action. Myron L. Bender, Lewis J. Brubacher (1975) (0)
- Abstract 3752: Identification of nanobodies specific for the oncogenic protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) that modulate its binding, stability, and phosphatase activity (2020) (0)
- 525. Therapy for Alzheimer's disease by neprilysin gene transfer (2004) (0)
- P4-091 Mechanisms of neuroprotection mediated by neprilysin in APP-transgenic mice (2006) (0)
- 96-1 Peptidases as potential targets for drug therapy (1997) (0)
- Book Review:Annual Review of Biochemistry. Volume 42. Esmond E. Snell, Paul D. Boyer, Alton Meister, Charles C. Richardson (1975) (0)
- O2-05-01 Peripheral expression of neprilysin decreases amyloid deposition in hAPP mice (2006) (0)
- Active beta-endorphin metabolites generated by T-cell ectopeptidases. (1995) (0)
- Development and characterization of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) (2022) (0)
- Demonstration of enzymic hydrogen transfer from substrate to a flavine (1974) (0)
- Intravitreally delivered neprilysin reduces amyloid-beta in the mouse eye (2015) (0)
- Insulin-degrading enzyme is not secreted from cultured cells (2018) (0)
- P2-343: Peripherally overexpessed neprilysin in muscle reduces brain amyloid in a transgenic mouse model of AD (2008) (0)
- N-Methyl-L-glutamate synthase. (1985) (0)
- The role of charged transmembrane residues of rVAChT on ACh transport and vesamicol binding (1998) (0)
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