Lynda Bonewald

Q: What Schools Are Affiliated With Lynda Bonewald

Lynda Bonewald is affiliated with the following schools: Indiana University Bloomington, University of Texas at Austin, Indiana University, University of Texas Health Science Center at San Antonio, University of Missouri–Kansas City, Indiana University–Purdue University Indianapolis, University of Missouri, Medical University of South Carolina, University of Virginia

Lynda Bonewald's AcademicInfluence.com Rankings

Lynda Bonewald

Biology

#5219

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#7648

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Anatomy

#28

World Rank

#160

Historical Rank

Cell Biology

#185

World Rank

#192

Historical Rank

Physiology

#146

World Rank

#315

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Biology

Why Is Lynda Bonewald Influential?

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According to Wikipedia, Lynda Bonewald is a professor of anatomy, cell biology, physiology, and orthopaedic surgery and the founding director of the Indiana Center for Musculoskeletal Health at the Indiana University School of Medicine. She studies bone and the musculoskeletal system. She has served as president of the American Society for Bone and Mineral Research and the Association of Biomolecular Resource Facilities .

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Lynda Bonewald's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Amazing Osteocyte (2010) (1846)
Evidence for osteocyte regulation of bone homeostasis through RANKL expression (2011) (1476)
Bioactive glass in tissue engineering. (2011) (1370)
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism (2006) (1108)
Osteocytes, mechanosensing and Wnt signaling. (2008) (1003)
Identification and Characterization of a Novel Protein, Periostin, with Restricted Expression to Periosteum and Periodontal Ligament and Increased Expression by Transforming Growth Factor β (1999) (799)
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. (1990) (773)
The osteocyte: an endocrine cell ... and more. (2013) (764)
Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis (2010) (512)
Establishment of an Osteocyte‐like Cell Line, MLO‐Y4 (1997) (499)
Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. (1999) (477)
Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. (2005) (439)
Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway (2011) (425)
Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation (2012) (401)
Osteocytes as Dynamic Multifunctional Cells (2007) (376)
Role of transforming growth factor-beta in bone remodeling. (1990) (374)
Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts (2002) (365)
Glucocorticoid‐Treated Mice Have Localized Changes in Trabecular Bone Material Properties and Osteocyte Lacunar Size That Are Not Observed in Placebo‐Treated or Estrogen‐Deficient Mice (2005) (338)
Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long‐term cultures of fetal rat calvarial osteoblasts (1994) (332)
Von Kossa Staining Alone Is Not Sufficient to Confirm that Mineralization In Vitro Represents Bone Formation (2003) (323)
MLO‐Y4 Osteocyte‐Like Cells Support Osteoclast Formation and Activation (2002) (317)
Implant Surface Characteristics Modulate Differentiation Behavior of Cells in the Osteoblastic Lineage (1999) (307)
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (2018) (305)
Dynamics of the transition from osteoblast to osteocyte (2010) (298)
DMP1-targeted Cre Expression in Odontoblasts and Osteocytes (2007) (297)
Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. (2012) (295)
Identification of Senescent Cells in the Bone Microenvironment (2016) (291)
Activation of the bone-derived latent TGF beta complex by isolated osteoclasts. (1989) (285)
Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein (1995) (282)
Osteoblast-Mediated Mineral Deposition in Culture is Dependent on Surface Microtopography (2002) (269)
Local communication on and within bone controls bone remodeling. (2009) (269)
Role of active and latent transforming growth factor β in bone formation (1994) (262)
Effects of miR‐335‐5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1 (2011) (261)
E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation (2006) (251)
Osteocyte lacunae tissue strain in cortical bone. (2006) (249)
Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression* (2006) (228)
Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix. (2002) (223)
Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone (2015) (217)
Bone and muscle: Interactions beyond mechanical. (2015) (210)
Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice. (1988) (206)
The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth. (2016) (203)
Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels (2012) (201)
Establishment of an Osteoid Preosteocyte‐like Cell MLO‐A5 That Spontaneously Mineralizes in Culture (2001) (200)
Dmp1-deficient Mice Display Severe Defects in Cartilage Formation Responsible for a Chondrodysplasia-like Phenotype* (2005) (198)
Effects of Mechanical Strain on the Function of Gap Junctions in Osteocytes Are Mediated through the Prostaglandin EP2 Receptor* (2003) (195)
Mechanosensation and Transduction in Osteocytes. (2006) (192)
Mechanical Induction of PGE2 in Osteocytes Blocks Glucocorticoid-Induced Apoptosis Through Both the β-Catenin and PKA Pathways (2010) (192)
Effects of combining transforming growth factor beta and 1,25-dihydroxyvitamin D3 on differentiation of a human osteosarcoma (MG-63). (1992) (190)
Expression of Functional Gap Junctions and Regulation by Fluid Flow in Osteocyte‐Like MLO‐Y4 Cells (2001) (188)
Cell line IDG‐SW3 replicates osteoblast‐to‐late‐osteocyte differentiation in vitro and accelerates bone formation in vivo (2011) (187)
A naturally occurring structural variant of human growth hormone. (1978) (183)
Mechanical Loading Stimulates Dentin Matrix Protein 1 (DMP1) Expression in Osteocytes In Vivo (2003) (180)
Glucocorticoid-Induced Autophagy in Osteocytes (2010) (180)
Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication (2017) (174)
FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. (2013) (171)
Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein. (1994) (170)
Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice. (2012) (163)
Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. II. In vitro and in vivo biological evaluation. (2010) (162)
The 20,000-dalton variant of human growth hormone: location of the amino acid deletions. (1980) (160)
The Osteocyte: New Insights. (2020) (160)
Role of the Latent Transforming Growth Factor β–Binding Protein 1 in Fibrillin‐Containing Microfibrils in Bone Cells In Vitro and In Vivo (2000) (156)
Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis. (2007) (155)
Establishment and characterization of an osteocyte-like cell line, MLO-Y4 (1999) (154)
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling. (2013) (153)
Localization of 1,25-(OH)2D3-responsive alkaline phosphatase in osteoblast-like cells (ROS 17/2.8, MG 63, and MC 3T3) and growth cartilage cells in culture. (1989) (152)
Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading* (2008) (151)
Maturation State Determines the Response of Osteogenic Cells to Surface Roughness and 1,25‐Dihydroxyvitamin D3 (2000) (148)
The effects of cytokines and growth factors on osteoblastic cells. (1995) (147)
Mechanism by which MLO-A5 Late Osteoblasts/Early Osteocytes Mineralize in Culture: Similarities with Mineralization of Lamellar Bone (2006) (143)
Glucocorticoid dose determines osteocyte cell fate (2011) (141)
Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli (2015) (135)
Osteocyte Remodeling of the Perilacunar and Pericanalicular Matrix (2009) (134)
Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2 (2013) (131)
Prostaglandin Promotion of Osteocyte Gap Junction Function through Transcriptional Regulation of Connexin 43 by Glycogen Synthase Kinase 3/β-Catenin Signaling (2009) (131)
PGE2 Is Essential for Gap Junction-Mediated Intercellular Communication between Osteocyte-Like MLO-Y4 Cells in Response to Mechanical Strain. (2001) (131)
Regulation and regulatory activities of transforming growth factor beta. (1999) (130)
The Biological Function of DMP-1 in Osteocyte Maturation Is Mediated by Its 57-kDa C-terminal Fragment (2010) (125)
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. (1991) (121)
DNA methylation contributes to the regulation of sclerostin expression in human osteocytes (2012) (121)
Role of active and latent transforming growth factor beta in bone formation. (1994) (120)
Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo (1996) (118)
Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. (2008) (117)
A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis (1990) (116)
Prostaglandin E2: from clinical applications to its potential role in bone- muscle crosstalk and myogenic differentiation. (2012) (113)
Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin. (2012) (112)
Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms. (2009) (110)
PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. (2001) (110)
β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. (2018) (110)
Latent Forms of Transforming Growth Factor-β (TGFβ) Derived from Bone Cultures: Identification of a Naturally Occurring 100-kDa Complex with Similarity to Recombinant Latent TGFβ (1991) (110)
Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. (2013) (106)
Forum on bone and skeletal muscle interactions: Summary of the proceedings of an ASBMR workshop (2013) (106)
Unique Roles of Phosphorus in Endochondral Bone Formation and Osteocyte Maturation (2010) (105)
Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice (2011) (105)
Deletion of a Single β‐Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading (2014) (105)
Effect of bioactive borate glass microstructure on bone regeneration, angiogenesis, and hydroxyapatite conversion in a rat calvarial defect model. (2013) (105)
Use of rapidly mineralising osteoblasts and short periods of mechanical loading to accelerate matrix maturation in 3D scaffolds. (2009) (105)
Evaluation of bone regeneration, angiogenesis, and hydroxyapatite conversion in critical-sized rat calvarial defects implanted with bioactive glass scaffolds. (2012) (103)
Dentin Matrix Protein 1 Gene Cis-regulation (2005) (101)
CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4. (2003) (101)
Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation (2018) (99)
Characterization of the latent transforming growth factor ß complex in Bone (1990) (97)
Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice. (2014) (97)
The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone. (2014) (97)
5-Lipoxygenase metabolites inhibit bone formation in vitro. (1998) (95)
FGF23 production by osteocytes (2013) (95)
Use it or lose it to age: A review of bone and muscle communication. (2019) (94)
Latent transforming growth factor-beta is produced by chondrocytes and activated by extracellular matrix vesicles upon exposure to 1,25-(OH)2D3. (1994) (93)
Degeneration of the osteocyte network in the C57BL/6 mouse model of aging (2017) (90)
Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice. (2013) (89)
5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices. (1993) (89)
Growth plate chondrocytes store latent transforming growth factor (TGF)‐β1 in their matrix through latent TGF‐β1 binding protein‐1 (1998) (88)
Periostin Is Essential for the Integrity and Function of the Periodontal Ligament During Occlusal Loading in Mice (2008) (88)
Preferential production of latent transforming growth factor β‐2 by primary prostatic epithelial cells and its activation by prostate‐specific antigen (2005) (87)
The Role of the Osteocyte in Bone and Nonbone Disease. (2017) (87)
Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity. (2013) (85)
An interchain disulfide dimer of human growth hormone. (1977) (83)
Composition of the extracellular matrix of the peritoneum. (2001) (82)
Osteocytes: a proposed multifunctional bone cell. (2002) (81)
Connexin 43 Channels Are Essential for Normal Bone Structure and Osteocyte Viability (2015) (80)
Altered proteolytic cleavage of human growth hormone as a result of deamidation. (1981) (76)
Direct effects of transforming growth factor-beta on chondrocytes are modulated by vitamin D metabolites in a cell maturation-specific manner. (1993) (75)
Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo (2017) (74)
DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix. (2007) (73)
Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation (2015) (73)
METTL21C Is a Potential Pleiotropic Gene for Osteoporosis and Sarcopenia Acting Through the Modulation of the NF‐κB Signaling Pathway (2014) (73)
Measurement of microstructural strain in cortical bone. (2005) (72)
Osteogenic differentiation of human umbilical cord mesenchymal stromal cells in polyglycolic acid scaffolds. (2010) (72)
Erk pathways negatively regulate matrix mineralization. (2007) (71)
Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability. (2004) (70)
Differential regulation of prostaglandin E2 synthesis and phospholipase A2 activity by 1,25-(OH)2D3 in three osteoblast-like cell lines (MC-3T3-E1, ROS 17/2.8, and MG-63). (1992) (70)
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus (2017) (70)
Osteocytes as multifunctional cells. (2006) (69)
Crosstalk Between MLO‐Y4 Osteocytes and C2C12 Muscle Cells Is Mediated by the Wnt/β‐Catenin Pathway (2017) (67)
Signalling strategies for osteogenic differentiation of human umbilical cord mesenchymal stromal cells for 3D bone tissue engineering (2009) (67)
Physiological and pathological osteocytic osteolysis (2018) (65)
Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. (2009) (65)
Dysapoptosis of Osteoblasts and Osteocytes Increases Cancellous Bone Formation But Exaggerates Cortical Porosity With Age (2014) (65)
Endochondral ossification for enhancing bone regeneration: converging native extracellular matrix biomaterials and developmental engineering in vivo. (2015) (64)
Evidence for distinct membrane receptors for 1α,25-(OH)2D3 and 24R,25-(OH)2D3 in osteoblasts (2002) (64)
Periodontal Breakdown in the Dmp1 Null Mouse Model of Hypophosphatemic Rickets (2008) (62)
Potential Mechanisms for the Plasmin-Mediated Release and Activation of Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Growth Plate Chondrocytes1. (1999) (62)
Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-beta on isolated osteoclasts. (1990) (61)
Osteoblast proliferation and differentiation on dentin slices are modulated by pretreatment of the surface with tetracycline or osteoclasts. (2000) (60)
Matrix vesicles produced by osteoblast-like cells in culture become significantly enriched in proteoglycan-degrading metalloproteinases after addition of β-Glycerophosphate and ascorbic acid (1994) (60)
Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia (2018) (60)
Enhanced bone regeneration in rat calvarial defects implanted with surface-modified and BMP-loaded bioactive glass (13-93) scaffolds. (2013) (58)
Osteocyte biology: its implications for osteoporosis. (2004) (57)
Generation and function of osteocyte dendritic processes. (2005) (55)
Studies of the DMP1 57-kDa Functional Domain both in vivo and in vitro (2008) (54)
Osteoinductive factor inhibits formation of human osteoclast-like cells. (1990) (53)
Studying osteocyte function using the cell lines MLO-Y4 and MLO-A5. (2012) (53)
Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells (2013) (52)
Identification of osteocyte‐selective proteins (2010) (51)
Human growth hormone: additional members of the complex. (1979) (51)
Interleukin‐1 receptor antagonist inhibits the hypercalcemia mediated by interleukin‐1 (1993) (50)
Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. (2009) (50)
Osteocyte messages from a bony tomb. (2007) (49)
Role of TGFβ in Bone Remodeling a (1990) (49)
Role of transforming growth factor beta in bone remodeling: a review. (1989) (49)
Stimulation of plasma membrane and matrix vesicle enzyme activity by transforming growth factor‐β in osteosarcoma cell cultures (1990) (48)
Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. (2010) (47)
Expression of Bone Morphogenetic Proteins by Osteoinductive and Non-osteoinductive Human Osteosarcoma Cells (1996) (47)
Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release (2008) (46)
Vitamin D3 metabolites regulate LTBP1 and latent TGF‐β1 expression and latent TGF‐β1 incorporation in the extracellular matrix of chondrocytes (1999) (46)
Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6 (1992) (44)
Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions. (2007) (43)
DMP1 is essential for osteocyte formation and function. (2005) (43)
Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection (1989) (43)
Time Lapse Imaging Techniques for Comparison of Mineralization Dynamics in Primary Murine Osteoblasts and the Late Osteoblast/Early Osteocyte-Like Cell Line MLO-A5 (2008) (42)
Osteoblastic cell lines derived from a transgenic mouse containing the osteocalcin promoter driving SV40 T-antigen (1995) (42)
Growth plate chondrocytes store latent transforming growth factor (TGF)-beta 1 in their matrix through latent TGF-beta 1 binding protein-1. (1998) (42)
Nitric Oxide and Prostaglandin E2 Production in Response to Ultra-High Molecular Weight Polyethylene Particles Depends on Osteoblast Maturation State (2002) (42)
Mice lacking 5-lipoxygenase have increased cortical bone thickness. (1997) (42)
Induction of Tumor Necrosis Factor-α in Murine Candida albicans Infection (1993) (42)
Stimulation of tumor necrosis factor release from monocytic cells by the A375 human melanoma via granulocyte-macrophage colony-stimulating factor. (1990) (41)
Erratum: Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (Cell (2018) 175(7) (1756–1768.e17), (S0092867418313345), (10.1016/j.cell.2018.10.025)) (2019) (39)
Characterization of the latent transforming growth factor beta complex in bone. (1990) (38)
ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass (2017) (38)
Erythropoietin fails to reverse the anemia in mice continuously exposed to tumor necrosis factor-alpha in vivo. (1990) (38)
Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age* (2015) (37)
Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition. (2016) (36)
Effects of nanomechanical bone tissue properties on bone tissue strain: implications for osteocyte mechanotransduction. (2008) (36)
Isolation and Functional Analysis of an Immortalized Murine Cementocyte Cell Line, IDG‐CM6 (2016) (35)
Preliminary evidence of early bone resorption in a sheep model of acute burn injury: an observational study (2013) (35)
Oral bone loss is increased in ovariectomized rats. (1997) (35)
Characterization and regulation of the latent transforming growth factor‐β complex secreted by vascular pericytes (1996) (35)
Postnatal Skeletal Deletion of Dickkopf‐1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression (2018) (34)
FGF23 Is Endogenously Phosphorylated in Bone Cells (2015) (33)
Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry‐Tagged Collagen Constructs (2018) (33)
The parathyroid hormone-regulated transcriptome in osteocytes: parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function. (2015) (33)
Stimulation of matrix vesicle enzyme activity in osteoblast-like cells by 1,25(OH)2D3 and transforming growth factor β (TGFβ) (1992) (33)
Activation of latent transforming growth factor beta during Chlamydia trachomatis-induced murine pneumonia. (1996) (32)
Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice (2019) (31)
Prostaglandin E2 is crucial in the response of podocytes to fluid flow shear stress (2010) (31)
Effects of synthetic peptido‐leukotrienes on bone resorption in vitro (1996) (31)
Characterization of a cell line derived from a human giant cell tumor that stimulates osteoclastic bone resorption. (1993) (31)
Expression of human transforming growth factor α by chinese hamster ovarian tumors in nude mice causes hypercalcemia and increased osteoclastic bone resorption (1992) (30)
Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms (2015) (30)
Cyclooxygenase-2, prostaglandin E2, and prostanoid receptor EP2 in fluid flow shear stress-mediated injury in the solitary kidney. (2014) (29)
Healing of critical-size segmental defects in rat femora using strong porous bioactive glass scaffolds. (2014) (29)
Potential mechanisms for the plasmin-mediated release and activation of latent transforming growth factor-beta1 from the extracellular matrix of growth plate chondrocytes. (1999) (28)
A Novel Osteogenic Cell Line That Differentiates Into GFP‐Tagged Osteocytes and Forms Mineral With a Bone‐Like Lacunocanalicular Structure (2019) (27)
Increased production of tumor necrosis factor by normal immune cells in a model of the humoral hypercalcemia of malignancy. (1990) (27)
Regulation of matrix vesicle metabolism by vitamin D metabolites. (1989) (26)
Role of TGF beta in bone remodeling. (1990) (26)
Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblasts. (2002) (26)
Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes (2019) (26)
Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis (2020) (25)
Dentin Matrix Protein 1 Gene Cis-regulation USE IN OSTEOCYTES TO CHARACTERIZE LOCAL RESPONSES TO MECHANICAL LOADING IN VITRO AND IN VIVO* (2005) (25)
Study on the synthesis and characterization of peptides containing phosphorylated tyrosine. (1999) (24)
Latent forms of transforming growth factor-beta (TGF beta) derived from bone cultures: identification of a naturally occurring 100-kDa complex with similarity to recombinant latent TGF beta. (1991) (23)
Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets (2016) (23)
Formation of a Disulfide Bond in an Octreotide-Like Peptide: A Multicenter Study (1996) (22)
Effects of Retinol on Activation of Latent Transforming Growth Factor-β by Isolated Osteoclasts. (1997) (22)
Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients (2019) (22)
Induction of tumor necrosis factor-alpha in murine Candida albicans infection. (1993) (21)
Generation of a conditional null allele for Dmp1 in mouse (2008) (20)
Long-term bone regeneration, mineralization and angiogenesis in rat calvarial defects implanted with strong porous bioactive glass (13–93) scaffolds (2016) (20)
Composition of the Extracellular Matrix of the Peritoneum (2001) (19)
Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity (2019) (19)
Sclerostin Directly Stimulates Osteocyte Synthesis of Fibroblast Growth Factor-23 (2020) (19)
In vitro and in vivo study on osteocyte-specific mechanical signaling pathways. (2004) (19)
Transforming Growth Factor-β (2008) (19)
Six-year study of peptide synthesis. (1997) (19)
Advancing our understanding of osteocyte cell biology (2009) (18)
Preface: the osteocyte. (2013) (18)
Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading (2016) (17)
The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community (2020) (17)
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors (2019) (16)
Osteoporosis update: proceedings of the 2013 Santa Fe Bone Symposium. (2014) (16)
Stimulation of matrix vesicle enzyme activity in osteoblast-like cells by 1,25(OH)2D3 and transforming growth factor beta (TGF beta). (1992) (15)
Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells (2019) (15)
Bioactive Glass in Bone Tissue Engineering (2012) (14)
BIOCHEMICAL CHARACTERIZATION OF HUMAN THY‐1 (1984) (13)
Role of Growth Factors in Cartilage and Bone Metabolism (1990) (13)
Muscle-Bone Crosstalk in Amyotrophic Lateral Sclerosis (2015) (13)
Chapter 49 – Transforming Growth Factor-β (2002) (13)
Analysis of racemization during "Standard" solid phase peptide synthesis: a multicenter study (1997) (13)
A novel osteoclast precursor cell line, 4B12, recapitulates the features of primary osteoclast differentiation and function: Enhanced transfection efficiency before and after differentiation (2009) (13)
The holy grail of high bone mass (2011) (12)
Hypoxia mediates osteocyte ORP150 expression and cell death in vitro. (2016) (12)
Evidence for the biclonal nature of a Waldenstrom's macroglobulinemia. (1985) (12)
Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes (2019) (12)
Isolation of osteocytes from mature and aged murine bone. (2015) (12)
Can transforming growth factor beta be useful as a protective agent for pluripotent hematopoietic progenitor cells? (1992) (11)
Chapter 4. Osteocytes (2009) (11)
Research Technologies: Fulfilling the Promise 1 (1999) (9)
The role of sphingosine-1-phosphate signaling pathway in cementocyte mechanotransduction. (2020) (9)
Computational fluid dynamic analysis of bioprinted self‐supporting perfused tissue models (2019) (9)
Role of myokines and osteokines in cancer cachexia (2021) (9)
Use of the transgenic approach to determine the role of DMP1 in phosphate regulation. (2007) (8)
Chemistry and Biology of Mineralized Tissues (2016) (8)
Antigenic determinant(s) shared by the human Thy 1 and human IgG. (1984) (8)
Effects of TNF and lymphotoxin on bone cells. (1992) (8)
Assays for bone resorption and bone formation. (1991) (8)
Molecular comparison of mouse Thy-1 and its human homologue. (1982) (7)
A novel cytokine with osteoclastopoietic activity. (1993) (7)
Non-bone metastatic cancers promote osteocyte-induced bone destruction. (2021) (7)
Restriction of C1 hemolytic function by human proline-rich salivary proteins. (1984) (7)
Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways (2019) (7)
Growth regulatory factors and bone cell function (1990) (7)
Correlation of cleavage techniques with side-reactions following solid-phase peptide synthesis (1995) (7)
Bone and Muscle (2019) (7)
Bone Cell Biology: Osteoclasts, Osteoblasts, Osteocytes (2012) (6)
Silorane resin supports proliferation, differentiation, and mineralization of MLO-A5 bone cells in vitro and bone formation in vivo. (2012) (6)
Effects of retinol on activation of latent transforming growth factor-beta by isolated osteoclasts. (1997) (6)
RANKL Blockade Reduces Cachexia and Bone Loss Induced by Non‐Metastatic Ovarian Cancer in Mice (2021) (6)
Evidence for pathophysiological crosstalk between bones, cardiac, skeletal and smooth muscles (2010) (5)
CHAPTER 8 – Osteocytes (2008) (5)
19. The Influence of Sputtered Bone Substitutes on Cell Growth and Phenotypic Expression (1991) (5)
Osteocyte Mechanosensation and Transduction (2011) (5)
The potential role of procathepsin D secreted by breast cancer cells in bone resorption (1990) (5)
DMP 1 is essential for osteocyte formation and function (5)
Does Defective Bone Lead to Defective Muscle? (2015) (5)
Cell–Cell and Cell–Matrix Interactions in Bone (2010) (5)
CHAPTER 339 – Cell–Cell and Cell–Matrix Interactions in Bone (2003) (4)
Summary--Osteocytes and mechanotransduction. (2005) (4)
The Osteocyte Network as a Source and Reservoir of Signaling Factors (2010) (4)
Osteocytes release microvesicles that regulate osteoblast function (2013) (4)
Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection (2022) (3)
The Musculoskeletal Knowledge Portal: improving access to multi-omics data (2021) (3)
Unraveling Osteocyte Signaling Networks: Meeting Report from the 31st Annual Meeting of the American Society for Bone and Mineral Research: September 11-15, 2009 in Denver, Colorado (2010) (3)
UTP and mechanical stimulation induce ATP release from osteocytes. (2012) (3)
Professional Societies, Association of Biomolecular Resource Facilities (2002) (3)
Osteocytes and Cancer (2021) (3)
Wnt3a and Wnt1 Enhance Myogenesis of C2C12 Myoblasts – Potential Mechanisms of Osteocyte to Muscle Cell Signaling (2015) (3)
Potential influences on optimizing long-term musculoskeletal health in children and adolescents with X-linked hypophosphatemia (XLH) (2022) (3)
The Role of Growth Factors in Bone Formation (1998) (3)
Degeneration of the osteocyte network in the C 57 BL / 6 mouse model of (2017) (3)
Osteocytes play to standing room only: Meeting report from the 30th Annual Meeting of the American Society for Bone and Mineral Research (2008) (3)
Isolation of Murine and Human Osteocytes. (2021) (3)
Chapter 10 – Osteocyte Biology (2013) (3)
Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism (2018) (2)
Latent Transforming Growth Factor+ Is Produced by Chondrocytes and Activated by Extracellular Matrix Vesicles upon Exposure to I,%-(OH),D,” (2001) (2)
Mef2c does more than regulate Sost in osteocytes: distinct gender effects (2012) (2)
Tissue strain transduction and amplification at the osteocyte as a result of microstructural changes in the bone matrix (2007) (2)
Osteocyte Remodeling of their Perilacunar/canalicular Matrix: Hormonal/Mechanical Regulation (2010) (2)
O-026 Preferential endometrial stromal cell adhesion to collagen IV and collagen I is inhibited by echistatin (1997) (2)
Eighth Bone Quality Seminar Proceedings 2013 (2014) (2)
Evidence that interleukin-1 mediates its effects on bone resorption via the 80 kilodalton interleukin-1 receptor (1993) (1)
Potential of Bioactive Glass Scaffolds as Implants for StructuralBone Repair (2015) (1)
Isolation and characterization of Thy 1 homologue from human thymus. (1985) (1)
1997 ABRF Peptide synthesis research committee study on a peptide containing a phosphorylated tyrosine (2002) (1)
Ultrastructural Evidence for Continued Synthetic Activity in Osteocytes (2011) (1)
Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease (2022) (1)
Quantitative mechanical/chemical imaging of bone from Dmp1 null mice (2009) (1)
Chapter 14 – Osteocyte Biology (2018) (1)
Effects of Estrogen on Growth Factors in Bone (1994) (1)
Measurement of Osteocyte Deformation Resulting From Fluid Flow Induced Shear Stress (1999) (1)
Cell Biology of Craniofacial Bone: Osteocytes (2013) (1)
Canonical Wnt/β-catenin signaling has positive effects on osteogenesis, but can have negative effects on cementogenesis. (2022) (1)
Osteocytes Support Hematopoiesis by Altering the Bone Marrow Microenvironment Through Gsα Signaling (2011) (1)
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus (2017) (1)
Self-organizing bone cell differentiation in vitro : a system in search of the "Edge of Chaos" (1993) (1)
Identification, function and regulation of cytokines related to bone and cartilage (2007) (0)
Osteocytes emerging from obscurity. Meeting report from the 29th Annual Meeting of the American Society for Bone and Mineral Research (2007) (0)
Direct hypertrophic effects of fibroblast growth factor 23 on cardiomyocytes (2012) (0)
Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis (2020) (0)
Osteocyte Wnt/ (cid:1) -Catenin Signaling Is Required for Normal Bone Homeostasis (cid:1) (2010) (0)
Investigation and Optimization of Silorane-Based Polymer System [abstract] (2010) (0)
Molecular biology of the osteocyte (2009) (0)
TumorNecrosis Factor AlphaIsaCytotoxin Induced byMurine Chlamydia trachomatis Infection (1989) (0)
ORP 150 expression in hypoxic osteocytes in vitro (2012) (0)
Crosstalk between Bone and Muscle: Deletion of Mbtps1 in Bone Leads to Age‐Dependent Increase in Muscle Size and Contractile Function (2015) (0)
Deletion of Dickkopf-1 in osteoblasts or osteocytes increases bone volume in female mice (2016) (0)
A RoleInVivoforTumorNecrosis Factor AlphainHostDefense against Chlamydia trachomatis (1990) (0)
Cells tissues organs. Introduction. (2009) (0)
Late osteoblast/early osteocyte-like cell line for visualizing collagen assembly in living cells [abstract] (2010) (0)
Introduction (2003) (0)
10. Bone Mineralization (2009) (0)
The MEPE-ASARM axis regulates chondrocyte matrix mineralisation (2012) (0)
List of contributors (2021) (0)
Decision letter: Modulation of fracture healing by the transient accumulation of senescent cells (2021) (0)
Introduction (2008) (0)
Chief Research Officers Panel [videorecording] (2010) (0)
Effects of muscle‐derived BAIBA on osteocytes with aging (2019) (0)
Regulation of endochondral ossification by the MEPE–ASARM axis (2012) (0)
Skeletal Muscle - Bone Crosstalk Regulating Osteocyte Function [abstract] (2010) (0)
Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin (2023) (0)
Beyond the mechanical in muscle-bone interaction (2015) (0)
L‐BAIBA Synergizes with Sub‐Optimal Mechanical Loading to Promote New Bone Formation (2023) (0)
Bone‐muscle crosstalk: more than mechanical (704.3) (2014) (0)
UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT) [abstract] (2010) (0)
Irisin Mediates Effects on Bone via αV Integrin Receptors (2019) (0)
ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass (2017) (0)
Imaging bone morphology down to submicron and nanoscale with lab based CT (2010) (0)
The Optimization and Effect of a Platinum Catalyst on the Mechanical and Handling Properties of Novel Silorane Bone Cements While Maintaining Osteogenic Capacity (2013) (0)
Strong Porous Bioactive Glass Scaffolds as Implants for Structural Bone Repair (2014) (0)
LIFE SCIENCES FORUM Research Technologies: Fulfilling the Promise (1999) (0)
Chemistry and Biology of Mineralized Tissues: 9th International Conference, Austin, Tex., November 2007 (2008) (0)
In vitro characteristics of human osteocyte-like cells derived from bone (1995) (0)
MEETING REPORTS Unraveling Osteocyte Signaling Networks: Meeting Report from the 31st Annual Meeting of the American Society for Bone and Mineral Research (2010) (0)
Targeted proteomics analysis of EGFP expressing metastatic breast cancer cells using mass spectrometry. (2007) (0)
Wnt3a potentiates myogenesis in C2C12 myoblasts through the modulation of intracellular calcium and activation of the β‐catenin signaling pathway (1102.23) (2014) (0)
Novel Silorane Bone Cements Exhibit Similar Mechanical Properties But None of the in Vivo Inflammatory Effects of Commercial Bone Cement (2013) (0)
CpG demethylation is critical for sclerostin expression in human osteoblastic cells (2012) (0)
Osteocytes: More Than Just Mechanosensory Cells (2020) (0)
Potential of bioact1ve glass scaffolds as implants for structural bone repair (2016) (0)
Prostaglandin E2 Signaling via EP4 Receptor is Important for Cell Cycle Progression and the Regulation of Reactive Oxygen Species Production in Primary Myoblast (2015) (0)
Osteoblast/ osteocyte interactions (2012) (0)
Novel Mechanisms and Roles of Glomerular Podocytes Cyclooxygenase-2 , prostaglandin E 2 , and prostanoid receptor EP 2 in fluid flow shear stress-mediated injury in the solitary kidney (2014) (0)
Biomedical Tissue Engineering - Where We Go in the Future (2010) (0)
Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background (2021) (0)
Regulation of chondrocyte matrix mineralisation by the MEPE-ASARM axis (2012) (0)
List of Reviewers 2002–2003 (2003) (0)
A multiscale computational model for mechanostat regulation in bone based on biochemical osteocyte feedback (2018) (0)
The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity (2011) (0)
Bone Repair and Military Readiness (2015) (0)
Osteocytes: An exquisitely sensitive mechanosensory cell (2014) (0)
Deletion of the fibronectin gene causes a dramatic delay in incorporation of LTBP1 into the extracellular matrix: rescue with exogenous fibronectin (2001) (0)
Osteocytes and bone homeostasis (2010) (0)
President's Preface (2013) (0)
Role of the Osteocyte in Musculoskeletal Disease. (2023) (0)
Impaired vascular function in female Dentin matrix protein 1 null mice (2011) (0)
Update on Osteocytes (Sun Valley 2012) (2013) (0)
JunctionStudy at the Crayfish Neuromuscular Role of NSF in Neurotransmitter Release: A Peptide (2015) (0)
A model of bone mechanostat directed by osteocytes mechanosensation (2018) (0)
Comparative Analysis of Osteoclast Lineage Cre-Drivers and Identification of Novel Osteoclast Lineage Selective Genes (2014) (0)
Osteocyte and Osteoblast Cell Models have Unique Patterns of Gene Expression and Responses to Mechanical Loading (2004) (0)
Osteocytes (2018) (0)
DELETION OF MBTPS1 IN BONE LEADS TO ENHANCEMENT OF MUSCLE MASS AND FUNCTION IN MATURE MICE (2013) (0)
Reviewer acknowledgment (2016) (0)
Cell lines for the study of bone formation and regulation [abstract] (2010) (0)
DENTIN MATRIX PROTEIN (DMP1) IS ELEVATED IN OSTEOCYTES IN RESPONSE TO MECHANICAL LOAD IN VIVO (2002) (0)
Nonmetastatic Colon Cancer Model C26 Upregulates Glycolysis in Osteocytes in Vitro and Bone in Vivo (2021) (0)

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