L. -f. Liu
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L. -f. Liubiology Degrees
Biology
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Molecular Biology
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Biochemistry
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#1096
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Chemistry Biology
L. -f. Liu's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is L. -f. Liu Influential?
(Suggest an Edit or Addition)L. -f. Liu's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. (1985) (2153)
- DNA topoisomerase poisons as antitumor drugs. (1989) (1819)
- Supercoiling of the DNA template during transcription. (1987) (1697)
- Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. (1984) (1428)
- Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. (1989) (1079)
- Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. (1988) (863)
- Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. (1984) (861)
- DNA topoisomerases: essential enzymes and lethal targets. (1994) (763)
- Topoisomerase II is a structural component of mitotic chromosome scaffolds (1985) (701)
- DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts. (1989) (667)
- Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. (1984) (536)
- Cleavage of DNA by mammalian DNA topoisomerase II. (1983) (499)
- Tumor cell death induced by topoisomerase-targeting drugs. (2001) (499)
- Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage. (1984) (476)
- Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. (1990) (461)
- Topoisomerase-targeting antitumor drugs. (1989) (446)
- DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. (1989) (370)
- Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. (1988) (364)
- A homogeneous type II DNA topoisomerase from HeLa cell nuclei. (1981) (315)
- Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei. (1981) (301)
- Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. (1988) (267)
- DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors. (1993) (250)
- Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells. (1988) (249)
- Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. (1987) (247)
- DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II. (1986) (246)
- Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I. (1995) (242)
- The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B. (1992) (229)
- DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA. (1989) (225)
- Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system. (1993) (222)
- SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage. (2000) (217)
- Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. (1984) (216)
- Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. (1996) (214)
- Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. (2001) (209)
- Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases. (1981) (206)
- DNA topoisomerases--enzymes that catalyse the breaking and rejoining of DNA. (1983) (195)
- DNA topoisomerases as anticancer drug targets. (1990) (195)
- A model for tumor cell killing by topoisomerase poisons. (1990) (193)
- Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. (1988) (183)
- Purification and characterization of a type II DNA topoisomerase from bovine calf thymus. (1985) (182)
- Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. (1991) (178)
- Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance. (1990) (177)
- Expression of alpha-amylases, carbohydrate metabolism, and autophagy in cultured rice cells is coordinately regulated by sugar nutrient. (1994) (163)
- Processing of topoisomerase I cleavable complexes into DNA damage by transcription. (1997) (160)
- Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress. (1999) (159)
- Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones. (1997) (158)
- Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. (1978) (155)
- A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures. (1993) (155)
- Anticancer activity evaluation of the solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells. (2000) (154)
- Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro. (1988) (154)
- Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. (2001) (149)
- Hypernegative supercoiling of the DNA template during transcription elongation in vitro. (1994) (141)
- Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells. (1985) (138)
- Metabolic derepression of alpha-amylase gene expression in suspension-cultured cells of rice. (1991) (137)
- Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines. (1990) (136)
- Knotted single-stranded DNA rings: a novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli omega protein. (1976) (133)
- Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne. (1996) (126)
- recA-independent and recA-dependent intramolecular plasmid recombination. Differential homology requirement and distance effect. (1994) (118)
- Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein. (1978) (111)
- DNA rearrangement mediated by inverted repeats. (1996) (103)
- Knotted DNA from bacteriophage capsids. (1981) (101)
- Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs. (1997) (100)
- Topoisomerase II levels during granulocytic maturation in vitro and in vivo. (1991) (100)
- Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons. (1996) (97)
- Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2. (1988) (95)
- Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs. (1989) (91)
- Intra- and intermolecular strand transfer by HeLa DNA topoisomerase I. (1982) (86)
- Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons. (1989) (82)
- Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. (1999) (81)
- Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. (1996) (79)
- Identification of the breakage-reunion subunit of T4 DNA topoisomerase. (1984) (79)
- Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions. (2000) (77)
- In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin (1986) (77)
- Poly(ADP-ribose)-mediated post-translational modification of chromatin-associated human topoisomerase I. Inhibitory effects on catalytic activity. (1989) (75)
- Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA. (1982) (71)
- In vitro functional characterization of bacterially expressed human fibroblast tropomyosin isoforms and their chimeric mutants. (1993) (70)
- Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors. (1995) (70)
- Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas. (1987) (68)
- ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB. (1991) (67)
- Nonhistone proteins HMG1 and HMG2 unwind DNA double helix. (1979) (66)
- A replicational model for DNA recombination between direct repeats. (1996) (66)
- On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy. (1975) (61)
- Differentially and developmentally regulated expression of three rice sucrose synthase genes. (1999) (60)
- Interaction between DNA and Escherichia coli DNA topoisomerase I. Formation of complexes between the protein and superhelical and nonsuperhelical duplex DNAs. (1979) (58)
- Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells. (1998) (55)
- Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins. (1983) (53)
- Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives. (1993) (51)
- DNA looping alters local DNA conformation during transcription. (1991) (47)
- Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors. (2000) (46)
- Topoisomerases: novel therapeutic targets in cancer chemotherapy. (1988) (45)
- Topoisomerase-targeting antitumor drugs: mechanisms of cytotoxicity and resistance. (1992) (41)
- Design of antineoplastic agents based on the "2-phenylnaphthalene-type" structural pattern. 4. Synthesis and biological activity of 2-chloro-3-(substituted phenoxy)-1, 4-naphthoquinones and related 5,8-dihydroxy-1,4-naphthoquinones. (1999) (38)
- Cellular resistance to topoisomerase poisons. (1996) (37)
- Regulations of granule-bound starch synthase I gene expression in rice leaves by temperature and drought stress (2006) (36)
- Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis. (1997) (35)
- Integration of simian virus 40 into cellular DNA occurs at or near topoisomerase II cleavage hot spots induced by VM-26 (teniposide) (1993) (35)
- Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar. (1997) (35)
- Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding. (1996) (35)
- Terbenzimidazoles: influence of 2"-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons. (1997) (33)
- Cell cycle-specific and transcription-related phosphorylation of mammalian topoisomerase I. (1995) (32)
- Template supercoiling during ATP-dependent DNA helix tracking: studies with simian virus 40 large tumor antigen. (1989) (32)
- Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons. (2000) (30)
- Mechanisms of resistance to topoisomerase inhibitors. (1994) (30)
- Quantitative structure-activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents. (1998) (30)
- Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin. (1994) (30)
- Involvement of intracellular ATP in cytotoxicity of topoisomerase II-targetting antitumor drugs. (1987) (29)
- Regulation of DNA topoisomerases during cellular differentiation. (1987) (29)
- Reaction of beta-lapachone and related naphthoquinones with 2-mercaptoethanol: a biomimetic model of topoisomerase II poisoning by quinones. (1998) (28)
- Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles. (2000) (27)
- Integration of the DNA of filamentous bacteriophage Cflt into the chromosomal DNA of its host (1987) (27)
- A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeats. (1997) (25)
- Roles of DNA topoisomerases in transcription. (1994) (24)
- Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity. (1999) (24)
- Expression of smooth muscle and nonmuscle tropomyosins in Escherichia coli and characterization of bacterially produced tropomyosins. (1993) (23)
- Inversion/dimerization of plasmids mediated by inverted repeats. (1999) (23)
- DNA topoisomerase II as a potential factor in drug resistance of human malignancies. (1987) (22)
- Plasmid linking number change induced by topoisomerase I-mediated DNA damage. (1999) (20)
- Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: a potential role of ligand-induced DNA bending at a distal site. (2000) (19)
- 2"-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons. (2000) (18)
- Nucleotide sequence of a class mu glutathione S-transferase from chicken liver. (1991) (18)
- Design of topoisomerase inhibitors to overcome MDR1-mediated drug resistance. (1994) (18)
- Studies on the role of the SlNAC3 gene in regulating seed development in tomato (Solanum lycopersicum) (2014) (18)
- Specific stimulation of recA-independent plasmid recombination by a DNA sequence at a distance. (1995) (18)
- Cloning and expression of a chick liver glutathione S-transferase CL 3 subunit with the use of a baculovirus expression system. (1992) (17)
- Effects of transcription and translation on gyrase-mediated DNA cleavage in Escherichia coli. (1990) (16)
- Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles. (1997) (16)
- Tyr115, gln165 and trp209 contribute to the 1, 2-epoxy-3-(p-nitrophenoxy)propane-conjugating activity of glutathione S-transferase cGSTM1-1. (2000) (16)
- recA-independent DNA recombination between repetitive sequences: mechanisms and implications. (1996) (14)
- Characterization and cloning of avian-hepatic glutathione S-transferases. (1999) (13)
- Genetic characterization of the mRNAs encoding alpha-bungarotoxin: isoforms and RNA editing in Bungarus multicinctus gland cells. (1998) (12)
- Reversible modification of rat liver glutathione S-transferase 3-3 with 1-chloro-2,4-dinitrobenzene: specific labelling of Tyr-115. (1993) (12)
- Spatial patterns of adults of greenhouse whiteflies Trialeurodes vaporariorum Westw. in greenhouses. (1980) (11)
- A protein factor from Xenopus oocytes with simian virus 40 large tumor antigen-like DNA supercoiling activity. (1990) (11)
- Interlocking of plasmid DNAs due to Lac repressor-operator interaction. (1992) (11)
- Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II. (1987) (11)
- Advances in Brief Histone Deacetylase Inhibitor UpRegulates RECK to Inhibit MMP-2 Activation and Cancer Cell Invasion 1 (2003) (10)
- Co-expression of glutathione S-transferase with methionine aminopeptidase: a system of producing enriched N-terminal processed proteins in Escherichia coli. (1999) (10)
- Characterization of chicken-liver glutathione S-transferase (GST) A1-1 and A2-2 isoenzymes and their site-directed mutants heterologously expressed in Escherichia coli: identification of Lys-15 and Ser-208 on cGSTA1-1 as residues interacting with ethacrynic acid. (1997) (8)
- Primary sequence of duck metallothionein. (1990) (7)
- Identification of a DNA supercoiling activity in Saccharomyces cerevisiae. (1992) (6)
- Expression of Yb1 glutathione S-transferase using a baculovirus expression system. (1989) (6)
- Incompatibility of Escherichia coli rho mutants with plasmids is mediated by plasmid-specific transcription (1997) (6)
- Topological approaches to studies of protein-mediated looping of DNA in vivo. (1992) (4)
- The decrease in polyamine levels is not associated with growth inhibition in suspension-cultured rice cells under nitrogen deficiency (1995) (3)
- Modification of glutathione S-transferase 3-3 mutants with 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone. Identification of the C-terminal tryptic fragment as part of the H-site and evidence that 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone is not specific for cysteine labelling. (1994) (3)
- First Report of Neocosmospora striata Causing Peanut Pod Rot in China. (2012) (2)
- Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver. (1993) (1)
- Studies on the rice protoplasts - factors affecting the isolation and viability. (1980) (1)
- Design of Antineoplastic Agents on the Basis of the “2‐ Phenylnaphthalene‐Type” Structural Pattern. Part 2. Synthesis and Biological Activity Studies of Benzo(b)naphtho(2,3‐d)furan‐6,11‐dione Derivatives. (2010) (1)
- HeLa toposiomerase I. (1983) (1)
- Somatic hybridizaion in the genus Nicotiana: N. sylvestris and N. tomentosiformis. (1990) (1)
- Crystallization and preliminary X-ray analysis of chicken-liver glutathione S-transferase CL 3-3. (1996) (1)
- Structure-activity relationship studies of 4- and 5-substituted terbenzimidazoles as topoisomerase I poisons (1996) (0)
- DNA Conformational Changes During RNA Transcription (1991) (0)
- Phorbol ester transiently stimulates dna topoisomerase i in arrested 3t3 cells (1990) (0)
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