Lawrence Hadley Thompson
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Lawrence Hadley Thompsonbiology Degrees
Biology
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Genetics
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Molecular Biology
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Biochemistry
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Biology
Lawrence Hadley Thompson's Degrees
- PhD Molecular Biology University of California, Berkeley
- Masters Biochemistry Stanford University
Why Is Lawrence Hadley Thompson Influential?
(Suggest an Edit or Addition)Lawrence Hadley Thompson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. (1999) (1308)
- Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle (2003) (1221)
- XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. (1998) (580)
- An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III (1994) (508)
- XRCC1 keeps DNA from getting stranded. (2000) (486)
- Recombinational DNA repair and human disease. (2002) (460)
- Homologous recombinational repair of DNA ensures mammalian chromosome stability. (2001) (454)
- Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange (1990) (408)
- Ouabain-resistant mutants of mouse and hamster cells in culture (1974) (385)
- Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. (1999) (350)
- Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. (2012) (345)
- A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange. (1982) (340)
- Human xeroderma pigmentosum group D gene encodes a DMA helicase (1993) (314)
- Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. (1995) (304)
- Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. (1995) (280)
- Molecular mechanisms of sister-chromatid exchange. (2007) (258)
- ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3. (1990) (250)
- Life without DNA repair. (1997) (234)
- Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents. (1985) (229)
- Chapter 7: Isolation of Mutants of Cultured Mammalian Cells (1973) (184)
- Reconstitution of Human Excision Nuclease with Recombinant XPF-ERCC1 Complex* (1997) (183)
- Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells (1988) (178)
- Proliferation kinetics of x-irradiated mouse L cells studied WITH TIME-lapse photography. II. (1969) (178)
- XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. (2003) (170)
- Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. (2009) (167)
- Genetic diversity of UV-sensitive DNA repair mutants of Chinese hamster ovary cells. (1981) (156)
- Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin Gene Conversion and DNA Repair through a Mechanism Related to Homologous Recombination (2005) (147)
- A mammalian cell mutant with a temperature-sensitive leucyl-transfer RNA synthetase. (1973) (145)
- Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells (2001) (145)
- Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair. (1998) (144)
- The contribution of homologous recombination in preserving genome integrity in mammalian cells. (1999) (141)
- Validation of conditions for efficient detection of HPRT and APRT mutations in suspension-cultured Chinese hamster ovary cells. (1980) (141)
- Identification of a novel human RAD51 homolog, RAD51B. (1997) (139)
- Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. (2002) (139)
- DNA crosslinking, sister-chromatid exchange and specific-locus mutations. (1979) (138)
- Fanconi Anemia FANCG Protein in Mitigating Radiation- and Enzyme-Induced DNA Double-Strand Breaks by Homologous Recombination in Vertebrate Cells (2003) (132)
- Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (2002) (127)
- ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs (1996) (125)
- Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions. (1995) (121)
- Defects in the DNA repair and transcription gene ERCC2 in the cancer-prone disorder xeroderma pigmentosum group D. (1995) (113)
- Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy. (1996) (111)
- Molecular cloning of the human DNA excision repair gene ERCC-6 (1990) (110)
- Evidence that mammalian cells possess homologous recombinational repair pathways. (1996) (108)
- Influence of double-strand-break repair pathways on radiosensitivity throughout the cell cycle in CHO cells. (2005) (107)
- How Fanconi anemia proteins promote the four Rs: Replication, recombination, repair, and recovery (2005) (107)
- Isolation of temperature-sensitive mutants of L-cells. (1970) (104)
- A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges. (1992) (103)
- Defective removal of DNA cross-links in a repair-deficient mutant of Chinese hamster cells. (1982) (103)
- Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and XRCC1, on human chromosome 19. (1989) (102)
- FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3 (2008) (97)
- Rare microsatellite polymorphisms in the DNA repair genesXRCC1, XRCC3 andXRCC5 associated with cancer in patients of varying radiosensitivity (1997) (92)
- Repression of mutagenesis by Rad51D-mediated homologous recombination (2006) (90)
- The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. (1997) (87)
- Summary of complementation groups of UV-sensitive CHO cell mutants isolated by large-scale screening. (1989) (86)
- CHO mutant UV61 removes (6-4) photoproducts but not cyclobutane dimers. (1989) (83)
- Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells. (1990) (80)
- Unraveling the Fanconi anemia–DNA repair connection (2005) (79)
- Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair. (1988) (78)
- Nomenclature of human genes involved in ionizing radiation sensitivity. (1995) (78)
- Recent Progress with the DNA Repair Mutants of Chinese Hamster Ovary Cells (1986) (76)
- Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells (1985) (75)
- Complementation of repair gene mutations on the hemizygous chromosome 9 in CHO: a third repair gene on human chromosome 19. (1989) (74)
- Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using a monoclonal antibody in Chinese hamster ovary cells. (1985) (74)
- Assignment of a human DNA-repair gene associated with sister-chromatid exchange to chromosome 19. (1986) (71)
- Excision repair in man and the molecular basis of xeroderma pigmentosum syndrome. (1993) (68)
- Rescue of Xrcc1 knockout mouse embryo lethality by transgene-complementation. (2003) (68)
- CHO cell mutants for arginyl-, asparagyl-, glutaminyl-, histidyl- and methionyl-transfer RNA synthetases: Identification and initial characterization (1977) (67)
- The relationship between sister-chromatid exchange and perturbations in DNA replication in mutant EM9 and normal CHO cells. (1983) (64)
- Selection by [3H] amino acids of CHO-cell mutants with altered leucyl- and asparagyl-transfer RNA synthetases (1975) (63)
- Rapid detection of DNA-damaging agents using repair-deficient CHO cells. (1984) (63)
- Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A (2009) (62)
- New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant. (2005) (61)
- An eighth complementation group of rodent cells hypersensitive to ultraviolet radiation (1988) (57)
- Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination (2006) (56)
- Somatic cell genetics approach to dissecting mammalian DNA repair (1989) (56)
- Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2. (2006) (55)
- The Fanconi anemia pathway limits the severity of mutagenesis. (2006) (55)
- Isolation of mutants of cultured mammalian cells. (1973) (55)
- Failure of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate to enhance sister chromatid exchange, mitotic segregation, or expression of mutations in Chinese hamster cells. (1980) (54)
- Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis. (2009) (54)
- Identification of nucleotide-excision-repair genes on human chromosomes 2 and 13 by functional complementation in hamster-human hybrids (1987) (53)
- DNA-strand breaks associated with halogenated pyrimidine incorporation. (1984) (53)
- Testis and somaticXrcc-1 DNA repair gene expression (1994) (50)
- Recombination and ligation of transfected DNA in CHO mutant EM9, which has high levels of sister chromatid exchange (1987) (50)
- Incorporated bromodeoxyuridine enhances the sister-chromatid exchange and chromosomal aberration frequencies in an EMS-sensitive Chinese hamster cell line. (1986) (49)
- Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation. (2010) (49)
- Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1. (1991) (48)
- Analysis of mammalian-cell mutagenesis and DNA repair using in-vitro selected CHO cell mutants (1983) (47)
- Proliferation kinetics of x-irradiated mouse L cells studied with time-lapse photography. I. Experimental methods and data analysis. (1967) (45)
- Repair of (6-4)photoproducts correlates with split-dose recovery in UV-irradiated normal and hypersensitive rodent cells. (1988) (44)
- Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicity and metabolic stability of nitracrine derivatives. (1989) (44)
- Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture (1982) (44)
- Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9. (1992) (44)
- DNA-mediated transfer of a human DNA repair gene that controls sister chromatid exchange (1985) (44)
- Genetic complementation between UV-sensitive CHO mutants and xeroderma pigmentosum fibroblasts. (1985) (43)
- The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia. (1987) (43)
- Molecular cloning of the human nucleotide-excision-repair gene ERCC4. (1994) (43)
- FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ (2011) (42)
- Properties and applications of human DNA repair genes. (1991) (42)
- Alterations in expression and structure of the DNA repair gene XRCC1. (1992) (41)
- Rodent UV-sensitive mutant cell lines in complementation groups 6-10 have normal general excision repair activity. (1997) (38)
- Conserved domains in the chicken homologue of BRCA2 (2002) (37)
- Nomenclature of human DNA repair genes. (1994) (36)
- Nucleotide Excision Repair (1998) (36)
- DNA-ligase activities appear normal in the CHO mutant EM9. (1984) (36)
- Role of DNA repair in mutagenesis of Chinese hamster ovary cells by 7-bromomethylbenz[a]anthracene. (1982) (36)
- Metabolic activation and cytogenetic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in Chinese hamster ovary cells expressing murine cytochrome P450 IA2. (1991) (34)
- A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity. (1996) (34)
- Hypersensitivity to cell killing and mutation induction by chemical carcinogens in an excision repair-deficient mutant of CHO cells. (1983) (34)
- Transfection of the cloned human excision repair gene ERCC-1 to UV-sensitive CHO mutants only corrects the repair defect in complementation group-2 mutants. (1988) (34)
- DNA-mediated cotransfer of excision repair capacity and drug resistance into chinese hamster ovary mutant cell line UV-135 (1984) (33)
- Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination. (2007) (32)
- XRCC3 ATPase Activity Is Required for Normal XRCC3-Rad51C Complex Dynamics and Homologous Recombination* (2004) (32)
- Phenotypic heterogeneity in nucleotide excision repair mutants of rodent complementation groups 1 and 4. (1997) (31)
- Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis. (1995) (31)
- Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage. (2011) (31)
- A CHO-cell mutant with a defect in cytokinesis (1976) (30)
- Poly(ADP-ribose) metabolism appears normal in EM9, a mutagen-sensitive mutant of CHO cells. (1984) (29)
- Proliferation kinetics of mouse L-P59 cells irradiated with ultraviolet light: a time-lapse photographic study. (1970) (28)
- Clonal variation in colony morphology and growth of CHO cells cultured on agar (1977) (27)
- Homologous recombination repair protects against particulate chromate-induced chromosome instability in Chinese hamster cells. (2007) (26)
- A yeast DNA repair gene partially complements defective excision repair in mammalian cells. (1988) (25)
- Cyclobutane-pyrimidine dimer excision in UV-sensitive CHO mutants and the effect of the human ERCC2 repair gene. (1990) (24)
- UV mutagenesis, cytotoxicity and split-dose recovery in a human-CHO cell hybrid having intermediate (6-4) photoproduct repair. (1989) (24)
- Regional mapping of human DNA excision repair gene ERCC4 to chromosome 16p13.13-p13.2. (1993) (24)
- Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesis (2007) (24)
- Sister chromatid exchange and gene mutation. (1982) (23)
- Characterization of revertants of the CHO EM9 mutant arising during DNA transfection. (1991) (22)
- Comparative mutagenic efficiencies of the DNA adducts from the cooked-food-related mutagens Trp-P-2 and IQ in CHO cells. (1985) (22)
- Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in gamma-irradiated CHO cells. (2010) (22)
- Nucleotide Excision Repair: Its Relation to Human Disease (1998) (22)
- Complementation group assignments of moderately UV-sensitive CHO mutants isolated by large-scale screening (FAECB). (1994) (22)
- The nature of conditionally lethal temperature‐sensitive mutations in somatic cells (1978) (21)
- Chinese hamster cells meet DNA repair: an entirely acceptable affair. (1998) (21)
- Apurinic/apyrimidinic endonuclease activities appear normal in the CHO-cell ethyl methanesulfonate-sensitive mutant, EM9. (1984) (21)
- Isolation and characterization of mouse Xrcc-1, a DNA repair gene affecting ligation. (1994) (21)
- [3H]Amino acid selection of aminoacyl-tRNA synthetase mutants of CHO cells: Evidence of homo- vs. hemizygosity at specific loci (1979) (20)
- Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines. (1992) (20)
- Sequence Conversion by Single Strand Oligonucleotide Donors via Non-homologous End Joining in Mammalian Cells* (2010) (19)
- Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes. (1990) (17)
- Genetic regulation of membrane function in mammalian cells in culture. (1973) (16)
- Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells (2013) (15)
- Response of mouse L-P59 cells to x-irradiation in the G2 phase. (1969) (15)
- Interactions involving the Rad 51 paralogs Rad 51 C and XRCC 3 in human cells (2002) (13)
- Poly (ADP-ribosylation) and DNA topoisomerase I in different cell lines. (1984) (11)
- Erratum: Identification of a novel human RAD51 homolog, RAD51B (Genomics (1997) 46:3 (476-479)) (1998) (11)
- The human XRCC 9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV 40 cells (1997) (11)
- Characterization of the hamster FancG/Xrcc9 gene and mutations in CHO UV40 and NM3. (2004) (11)
- Strategies for cloning mammalian DNA repair genes. (1999) (11)
- An informative panel of somatic cell hybrids for physical mapping on human chromosome 19q. (1993) (10)
- Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells. (2000) (10)
- [26] Mutant isolation (1979) (10)
- Stabilizing and remodeling the blocked DNA replication fork: anchoring FANCM and the Fanconi anemia damage response. (2010) (9)
- Mutant isolation. (1979) (9)
- Role of the Fancg gene in protecting cells from particulate chromate-induced chromosome instability. (2007) (8)
- Restoration of Nucleotide Excision Repair in a Helicase-DeficientXPD Mutant from Intragenic Suppression by a Trichothiodystrophy Mutation (2001) (8)
- Isolating human DNA repair genes using rodent-cell mutants (1987) (8)
- Newly identified CHO ERCC3/XPB mutations and phenotype characterization. (2010) (7)
- Nuclear localization of Rad51B is independent of Rad51C and BRCA2. (2005) (7)
- Sister chromatid exchange, DNA repair, and single-gene mutation (1981) (7)
- DNA repair genes of mammalian cells. (1986) (7)
- Partial Correction of the Single‐Strand Break Repair Defect in the CHO Mutant EM9 by Electroporated Recombinant XRCC1 Protein a (1994) (6)
- Human DNA Repair and Recombination Genes (1989) (5)
- Using repair-deficient Chinese hamster ovary cells to study mutagenesis (1986) (5)
- Codominance associated with overexpression of certain XPD mutations. (2001) (4)
- Recent developments with the human repair genes ERCC2, ERCC4, and XRCC1 (1992) (3)
- RAD51D- and FANCG-dependent base substitution mutagenesis at the ATP1A1 locus in mammalian cells. (2009) (2)
- Identifying genes and proteins involved in human DNA repair processes using somatic cell and molecular genetics. (1996) (2)
- Correction: FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ (2011) (2)
- Molecular Cloning of the Human DNA Excision Repair (2)
- Construction of human XRCC 1 minigenes that fully correct the CHO DNA repair mutant EM 9 (2005) (2)
- Isolation ofTemperature-Sensitive MutantsofL-Cells* (1970) (1)
- Cytogenetic characterization of the CHO mutant EM9 (1983) (1)
- Recombination in Vertebrate Cells Double-Strand Breaks by Homologous Radiation-and Enzyme-Induced DNA Fanconi Anemia FANCG Protein in Mitigating (2003) (1)
- Recent progress in characterizing human DNA repair genes cloned using rodent cell lines (1991) (1)
- Cytogenetic characterization of the Chinese hamster ovary mutant EM9. (1984) (0)
- Life without DNA repair ( DNA damage y base excision repair y knockout mutations y transgenic mice ) (1997) (0)
- The use of DNA-repair-deficient mutants of Chinese hamster ovary cells in studying mutagenesis mechanisms and testing for environmental mutagens. (1983) (0)
- Molecular Cloning and Biological Characterization of a Human Gene, ERCC2, That Corrects the Nucleotide Excision (2003) (0)
- Repair Machinery for Radiation-Induced DNA Damage (2002) (0)
- Sequence analysis of the APRT gene in PhIP-induced CHO UV5P3 mutants (1994) (0)
- P V.2 Comparative sequence analysis of human and rodent DNA repair genes (1997) (0)
- Role of Fanconi Anemia FANCG in Preventing Double-Strand Breakage and Chromosomal Rearrangement during DNA Replication (2003) (0)
- Dissecting human DNA repair. (1987) (0)
- Unraveling the Fanconi anaemia-DNA repair connection through DNA helicase and translocase activities (2005) (0)
- Homologous Recombinational Repair The Rad 51 Paralog Rad 51 B Promotes (2000) (0)
- S21 05 WA – ANALYSIS OF GENES INVOLVED IN SENSITIVITY TO IONIZING RADIATION (1991) (0)
- A somatic cell and molecular genetics approach to DNA repair and mutagenesis. (1986) (0)
- PROLIFERATION KINETICS AND CELL SURVIVAL OF X-IRRADIATED MAMMALIAN CELLS IN VITRO (1969) (0)
- A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation sensitivity group of mitomycin C (1996) (0)
- Are sister chromatid exchanges a measure of single gene mutations (1978) (0)
- P25 14 WP – MOLECULAR ANALYSIS OF THE MAMMALIAN XRCC1 DNA REPAIR GENE (1991) (0)
- Examination of APRT in presumptive CHO heterozygotes (1981) (0)
- Double Strand Break Repair (2004) (0)
- Molecular cloning of the human nucleotide-excision-repair gene ERCC 4 ( DNA repi / cl Ne UV 41 / excdnuclease / genefic compemenaon / UV rance ) (0)
- Four human FANCG polymorphic variants show normal biological function in hamster CHO cells. (2006) (0)
- Cell survival determined by colony formation assay after acute or chronic exposure to MMC (2011) (0)
- NOTES DNA-Mediated Transfer ofaHumanDNA Repair GeneThat Controls Sister Chromatid Exchange (1985) (0)
- Nuclear localization of Rad 51 B is independent of Rad 51 C and BRCA 2 (2005) (0)
- uv excision-repair gene transfer in Chinese hamster ovary (CHO) cells (1983) (0)
- Role of DNA repair in mutagenesis by 7-bromomethylbenz(a)anthracer (mutagen sensitivity/mutation induction/sister chromatid exchange/t (2016) (0)
- Defective Removal of DMA Cross-Links in a Repair-deficient Mutant of Chinese Hamster Cells1 (2006) (0)
- Losing and finding myself in DNA repair. (2012) (0)
- Defective DMA Cross-Link Removal in Chinese Hamster Cell Mutants Hypersensitive to Bifunctional Alkylating Agents1 (2006) (0)
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What Schools Are Affiliated With Lawrence Hadley Thompson?
Lawrence Hadley Thompson is affiliated with the following schools: