Lester I. Binder
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Lester I. Binder's AcademicInfluence.com Rankings
Lester I. Binderphilosophy Degrees
Philosophy
#8533
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#11939
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Logic
#5563
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#6971
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Lester I. Binderbiology Degrees
Biology
#11568
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#14972
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Neuroscience
#1882
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#1938
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Philosophy Biology
Lester I. Binder's Degrees
- PhD Neuroscience University of California, Berkeley
- Doctorate Medicine Stanford University
Why Is Lester I. Binder Influential?
(Suggest an Edit or Addition)Lester I. Binder's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. (1986) (3176)
- The distribution of tau in the mammalian central nervous system (1985) (1444)
- Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease (2003) (808)
- Tau is essential to β-amyloid-induced neurotoxicity (2002) (725)
- Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology (1987) (705)
- Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) (1986) (687)
- Epitopes that span the tau molecule are shared with paired helical filaments (1988) (485)
- Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. (1992) (483)
- Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. (2001) (481)
- The periodic association of MAP2 with brain microtubules in vitro (1979) (441)
- Axonal Transport Defects in Neurodegenerative Diseases (2009) (434)
- Tau is essential to beta -amyloid-induced neurotoxicity. (2002) (426)
- Phosphorylation determines two distinct species of Tau in the central nervous system. (1987) (412)
- The Structural Basis of Monoclonal Antibody Alz50's Selectivity for Alzheimer's Disease Pathology* (1996) (380)
- Tau, tangles, and Alzheimer's disease. (2005) (377)
- Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture (1986) (352)
- Differential subcellular localization of tubulin and the microtubule- associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies (1984) (351)
- Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. (1997) (336)
- MAP2 is localized to the dendrites of hippocampal neurons which develop in culture. (1984) (318)
- In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice (2011) (310)
- C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. (2000) (297)
- β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis (2007) (292)
- Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease* (2011) (281)
- Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease (2005) (239)
- Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases (2011) (236)
- The amino terminus of tau inhibits kinesin‐dependent axonal transport: Implications for filament toxicity (2009) (235)
- Biochemical and immunological analyses of cytoskeletal domains of neurons (1986) (234)
- Heterogeneity of microtubule-associated protein 2 during rat brain development. (1984) (221)
- Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease (2004) (209)
- Differential Localization of MAP‐2 and Tau in Mammalian Neurons in Situ a (1986) (209)
- Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease (2012) (203)
- Tau oligomers and tau toxicity in neurodegenerative disease. (2012) (201)
- Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease (2002) (199)
- Immunocytochemical localization of actin and microtubule-associated protein MAP2 in dendritic spines. (1983) (198)
- Mild cognitive impairment: pathology and mechanisms (2011) (190)
- Identification of nuclear tau isoforms in human neuroblastoma cells. (1990) (189)
- The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture (1987) (187)
- Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. (2007) (181)
- Neuronal microtubule‐associated proteins in the embryonic avian spinal cord (1988) (172)
- Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system (2013) (165)
- Proteolysis of tau by calpain. (1989) (164)
- Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease. (2003) (160)
- Differential Assembly of Human Tau Isoforms in the Presence of Arachidonic Acid (2000) (156)
- Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo (2006) (150)
- Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment. (2003) (143)
- Ligand-dependent tau filament formation: implications for Alzheimer's disease progression. (1999) (141)
- Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases (2000) (140)
- A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. (1999) (140)
- Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease. (2005) (136)
- Oxidative regulation of fatty acid-induced tau polymerization. (2000) (134)
- FILAMENTOUS AGGREGATES IN PICK'S DISEASE, PROGRESSIVE SUPRANUCLEAR PALSY, AND ALZHEIMER'S DISEASE SHARE ANTIGENIC DETERMINANTS WITH MICROTUBULE-ASSOCIATED PROTEIN, TAU (1986) (133)
- Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody (2012) (132)
- Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease (2008) (131)
- Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease (2008) (130)
- A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration (2006) (130)
- In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants. (2000) (129)
- Tau Nitration Occurs at Tyrosine 29 in the Fibrillar Lesions of Alzheimer's Disease and Other Tauopathies (2006) (123)
- A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau (1993) (123)
- Assembly of Chick Brain Tubulin onto Isolated Basal Bodies of Chlamydomonas reinhardi (1974) (119)
- Tau polymerization: role of the amino terminus. (2003) (114)
- Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport (2012) (113)
- Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties (1990) (112)
- Nitration in neurodegeneration: deciphering the "Hows" "nYs". (2007) (111)
- Modeling tau polymerization in vitro: a review and synthesis. (2003) (111)
- Tau as a therapeutic target in neurodegenerative disease. (2012) (109)
- Presence of tau in isolated nuclei from human brain (1995) (106)
- Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. (2011) (106)
- Assembly of chick brain tubulin onto flagellar microtubules from Chlamydomonas and sea urchin sperm. (1975) (102)
- Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. (2011) (94)
- The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy (2003) (89)
- Tau‐66: evidence for a novel tau conformation in Alzheimer's disease (2001) (89)
- Site-specific nitration differentially influences tau assembly in vitro. (2005) (88)
- Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1. (1988) (87)
- Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. (2009) (86)
- Microtubule-associated protein 2 within axons of spinal motor neurons: associations with microtubules and neurofilaments in normal and beta,beta'-iminodipropionitrile-treated axons (1985) (86)
- The in vitro assembly of flagellar outer doublet tubulin (1978) (85)
- Staging of Alzheimer's Pathology in Triple Transgenic Mice: A Light and Electron Microscopic Analysis (2010) (83)
- Expression of microtubule-associated protein 2 by reactive astrocytes. (1990) (82)
- Tau as a nucleolar protein in human nonneural cells in vitro and in vivo (1996) (77)
- Polymerization of Microtubule-associated Protein Tau under Near-physiological Conditions (*) (1995) (77)
- Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells (1988) (71)
- N-terminal fragments of tau inhibit full-length tau polymerization in vitro. (2006) (69)
- Phosphorylation and cleavage of tau in non-AD tauopathies (2007) (68)
- A possible link between astrocyte activation and tau nitration in Alzheimer's disease (2008) (68)
- Formation of Phospho-SAPK/JNK Granules in the Hippocampus Is an Early Event in Alzheimer Disease (2006) (66)
- Nitrotyrosine formation with endotoxin-induced kidney injury detected by immunohistochemistry. (1999) (66)
- Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo (2015) (65)
- Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. (2006) (64)
- Hsp70 alters tau function and aggregation in an isoform specific manner. (2012) (61)
- Active c‐jun N‐terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK‐3β is required for tau aggregation (2008) (61)
- Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments. (2001) (58)
- Rapid reversible phosphorylation of rat brain tau proteins in response to cold water stress (1995) (57)
- DIRECTIONALITY AND RATE OF ASSEMBLY OF CHICK BRAIN TUBULIN ONTO PIECES OF NEUROTUBULES, FLAGELLAR AXONEMES, AND BASAL BODIES (1975) (52)
- Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology (2007) (52)
- Phylogenetic conservation of brain microtubule-associated proteins MAP2 and TAU (1988) (50)
- Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2). (1992) (50)
- TOC1: characterization of a selective oligomeric tau antibody. (2013) (50)
- Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease. (2011) (48)
- Nucleolar localization of the microtubule-associated protein tau in neuroblastomas using sense and anti-sense transfection strategies. (1997) (44)
- Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms. (2006) (43)
- Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer’s disease and tauopathies to granulovacuolar degeneration bodies (2006) (43)
- Prefibrillar Tau Oligomers in Mild Cognitive Impairment and Alzheimer's Disease (2013) (43)
- Cultured neurons contain a variety of microtubule-associated proteins (1985) (42)
- Pathological glial tau accumulations in neurodegenerative disease: review and case report (2001) (41)
- Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. (2013) (40)
- Solubility of cytoskeletal proteins in immunohistochemistry and the influence of fixation. (1993) (39)
- Tau epitope display in progressive supranuclear palsy and corticobasal degeneration (2004) (39)
- Galanin plasticity in the cholinergic basal forebrain in Alzheimer’s disease and transgenic mice (2005) (38)
- Differential localization of the high- and low-molecular weight variants of MAP2 in the developing retina. (1988) (36)
- Ubiquitin is Associated with Early Truncation of Tau Protein at Aspartic Acid421 during the Maturation of Neurofibrillary Tangles in Alzheimer's Disease (2012) (35)
- Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation. (2011) (34)
- Selective tau tyrosine nitration in non-AD tauopathies (2011) (33)
- Differential distribution of tau proteins in developing cat cerebellum (1994) (32)
- Localization of Specific Epitopes on Human Microtubule‐Associated Protein 2 (1994) (31)
- Identification of the intermediate filament-associated protein gyronemin as filamin. Implications for a novel mechanism of cytoskeletal interaction. (1992) (29)
- Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease (2016) (24)
- TOC1: A valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy (2014) (21)
- Alterations in the nuclear architecture produced by the overexpression of tau protein in neuroblastoma cells. (2013) (19)
- Conformational changes and cleavage; are these responsible for the tau aggregation in Alzheimer’s disease? (2009) (18)
- Detection of the microtubule cytoskeleton of the coccidian Toxoplasma gondii and the hemoflagellate Leishmania donovani by monoclonal antibodies specific for beta-tubulin. (1985) (16)
- Identification and characterization of a novel mammalian intermediate filament-associated protein. (1990) (15)
- Evidence that MAP-2 may be involved in pigment granule transport in squirrel fish erythrophores. (1987) (13)
- Tau oligomers as potential targets for early diagnosis of tauopathy. (2014) (13)
- Histochemical Localization of Acid Phosphatase in the Injured Rabbit Lens (1975) (13)
- Expression of the cytoskeletal-associated protein filamin in adult rat organs. (1993) (12)
- Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro. (2009) (11)
- A monoclonal antibody to microtubule-associated protein 2 (MAP2) localizes with neurofilaments in the β,β-iminodipropionitrile (IDPN) model (1982) (6)
- Neurobiology of Disease Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer ’ s Disease (2004) (6)
- IMMUNE ELECTRON MICROSCOPY OF PAIRED HELICAL FILAMENTS (PHF) WITH TAU ANTIBODIES: 132 (1987) (5)
- Tau Protein: Biology and Pathobiology (2015) (5)
- The Cytomatrix Regulates “Resolute” Transport in Erythrophores (1986) (4)
- X-ray diffraction from intact tau aggregates in human brain tissue. (2011) (4)
- Tubulin composition and microtubule nucleation of a griseofulvin-resistant Chinese hamster ovary cell mutant with abnormal spindles. (1985) (3)
- Identification of nuclear X isoforms in human neuroblastoma cells (3)
- Pathology of the Cleaved Tau Protein in the Context of Toxicity and the Formation of Neurofibrillary Tangles (2009) (2)
- Pathological Stages of Abnormally Processed Tau Protein During Its Aggregation into Fibrillary Structures in Alzheimer’s Disease (2011) (1)
- Microtubule-associated Protein 2 within Axons of Spinal Motor Neurons: Associations Microtubules and Neurofilaments in Normal and/3,/ '-Iminodipropionitrile-treated Axons (2003) (1)
- Microtubule-associated protein 2 and actin colocalize with segregated axonal neurofilaments and microtubules, respectively (1984) (1)
- Actin-binding protein is a component of bovine erythrocytes. (1993) (1)
- The Distribution Central Nervous of Tau in System the Mammalian (2002) (1)
- Proteolysis of tauby calpain (1989) (1)
- 15 THE AXONAL CYTOSKELETON IN THE β, β1-IMINODIPROPIONITRILE (IDPN) MODEL (1983) (1)
- Mono clonal antibodies to beta tubulin distinguish different micro tubule classes in cho cells (1983) (0)
- AFLUID July 46/1 (1999) (0)
- Alzheimer's disease: A route to drug discovery (1994) (0)
- Keratins 1 and 10 in SENCAR Mice Is Associated with Altered Expression of Ornithine Decarboxylase Expression in Cutaneous Papillomas Updated (2006) (0)
- A new molecular link between granulovacuolar and neurofibrillary lesions of Alzheimer's disease (2000) (0)
- Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody (2012) (0)
- The End of a Chilean Institute (2005) (0)
- Nitrotyrosine formation with endotoxin-induced kidney injury detected by immunohistochemistry. (1999) (0)
- THE EFFECTS OF SODIUM NITROPRUSSIDE AND L-GLUTAMATE ON THE REGULATION OF THE CYTOSKELETAL ASSOCIATED PROTEIN TAU IN PRIMARY CULTURED NEURONS FROM RAT (1995) (0)
- S3-03-02 Tau cleavage (2006) (0)
- Use of Antibodies and Microscopy to Ascertain the Structure of Tau in the Neurofibrillary Tangles of Alzheimer's Disease (2004) (0)
- The structural basis of tau filament formation (2000) (0)
- PHOSPHORYLATED TAU PROTEIN IS PRESENT IN NEURONAL CELL BODIES AND DENDRITES OF CONTROL AND β,β'‐IMINODIPROPIONITRILE (IDPN)‐TREATED RATS. IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMER'S DISEASE (AD): 53 (1987) (0)
- PL-02-01: Tau modifications, aggregation and toxicity (2008) (0)
- Micro tubule associated protein 2 and micro tubule associated protein 1 involvement in pigment granule transport in erythrophores (1983) (0)
- 43 DISTRIBUTION OF MICROTUBULE-ASSOCIATED PROTEIN 2 (MAP2) IN NERVOUS TISSUE. THE EFFECTS OF DEPHOSPHORYLATION AND β,β'-IMINODIPROPIONITRILE (IDPN) (1984) (0)
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