Lance L. Simpson
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Lance L. Simpsonmedical Degrees
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Toxicology
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#43
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Pharmacology
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Lance L. Simpsonphilosophy Degrees
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Medical Philosophy
Lance L. Simpson's Degrees
- PhD Pharmacology University of California, San Francisco
- Doctorate Medicine University of California, San Francisco
Why Is Lance L. Simpson Influential?
(Suggest an Edit or Addition)Lance L. Simpson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The origin, structure, and pharmacological activity of botulinum toxin. (1981) (575)
- Identification of the major steps in botulinum toxin action. (2004) (519)
- Molecular pharmacology of botulinum toxin and tetanus toxin. (1986) (450)
- Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of NeurologySYMBOL (2008) (337)
- Botulinum neurotoxin and tetanus toxin (1989) (314)
- Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction. (1980) (296)
- Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes. (1985) (269)
- Binding and Transcytosis of Botulinum Neurotoxin by Polarized Human Colon Carcinoma Cells* (1998) (129)
- The life history of a botulinum toxin molecule. (2013) (111)
- THE BINDING OF BOTULINUM TOXIN TO MEMBRANE LIPIDS: SPHINGOLIPIDS, STEROIDS AND FATTY ACIDS (1971) (111)
- Inhalational Poisoning by Botulinum Toxin and Inhalation Vaccination with Its Heavy-Chain Component (2003) (110)
- Pure Botulinum Neurotoxin Is Absorbed from the Stomach and Small Intestine and Produces Peripheral Neuromuscular Blockade (1999) (107)
- Inhibition of vacuolar adenosine triphosphatase antagonizes the effects of clostridial neurotoxins but not phospholipase A2 neurotoxins. (1994) (106)
- Synaptic Vesicle Movements Monitored by Fluorescence Recovery after Photobleaching in Nerve Terminals Stained with FM1-43 (1996) (102)
- Ganglioside inactivation of botulinum toxin (1971) (97)
- Molecular basis for the pathological actions of Clostridium perfringens iota toxin (1987) (95)
- Ammonium chloride and methylamine hydrochloride antagonize clostridial neurotoxins. (1983) (93)
- Structural Features of the Botulinum Neurotoxin Molecule That Govern Binding and Transcytosis across Polarized Human Intestinal Epithelial Cells (2004) (93)
- In vitro characterization of botulinum toxin types A, C and D action on human tissues: combined electrophysiologic, pharmacologic and molecular biologic approaches. (1997) (87)
- An Initial Assessment of the Systemic Pharmacokinetics of Botulinum Toxin (2006) (86)
- Trivalent Vaccine against Botulinum Toxin Serotypes A, B, and E That Can Be Administered by the Mucosal Route (2007) (83)
- α‐Latrotoxin action probed with recombinant toxin: receptors recruit α‐latrotoxin but do not transduce an exocytotic signal (1998) (82)
- Induction of an immune response by oral administration of recombinant botulinum toxin (1997) (79)
- Cellular and molecular actions of binary toxins possessing ADP-ribosyltransferase activity. (1991) (74)
- Molecular basis for the pharmacological actions of Clostridium botulinum type C2 toxin. (1984) (71)
- The interaction between aminoquinolines and presynaptically acting neurotoxins. (1982) (71)
- A comparison of the pharmacological properties of Clostridium botulinum type C1 and C2 toxins. (1982) (70)
- Assessment: botulinum neurotoxin for the treatment of spasticity (an evidence-based review). (2009) (69)
- Lectins from Triticum vulgaris and Limax flavus are universal antagonists of botulinum neurotoxin and tetanus toxin. (1991) (67)
- Identification of the characteristics that underlie botulinum toxin potency: implications for designing novel drugs. (2000) (64)
- Production by Clostridium spiroforme of an iotalike toxin that possesses mono(ADP-ribosyl)transferase activity: identification of a novel class of ADP-ribosyltransferases (1989) (64)
- Evidence that deprenyl, A type B monoamine oxidase inhibitor, is an indirectly acting sympathomimetic amine. (1978) (63)
- Visualization of Binding and Transcytosis of Botulinum Toxin by Human Intestinal Epithelial Cells (2005) (61)
- The role of calcium in neurohumoral and neurohormonal extrusion processes (1968) (61)
- Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain (2008) (55)
- Botulinum neurotoxin type E: studies on mechanism of action and on structure-activity relationships. (1983) (54)
- Animal Studies (2004) (49)
- Identification of the site at which phospholipase A2 neurotoxins localize to produce their neuromuscular blocking effects. (1993) (47)
- Chelation of zinc antagonizes the neuromuscular blocking properties of the seven serotypes of botulinum neurotoxin as well as tetanus toxin. (1993) (46)
- Efficient Serum Clearance of Botulinum Neurotoxin Achieved Using a Pool of Small Antitoxin Binding Agents (2009) (44)
- Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine. (2007) (42)
- The Role of the Interchain Disulfide Bond in Governing the Pharmacological Actions of Botulinum Toxin (2004) (42)
- A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism (1986) (42)
- The binding fragment from tetanus toxin antagonizes the neuromuscular blocking actions of botulinum toxin. (1984) (42)
- Pharmacological studies on the subcellular site of action of botulinum toxin type A. (1978) (41)
- The Role of Zinc Binding in the Biological Activity of Botulinum Toxin* (2001) (41)
- An adenoviral vector-based mucosal vaccine is effective in protection against botulism (2009) (39)
- The action of botulinal toxin. (1979) (38)
- Studies on the binding of botulinum toxin type A to the rat phrenic nerve-hemidiaphragm preparation. (1974) (37)
- Botulinum toxin and tetanus toxin recognize similar membrane determinants (1984) (35)
- Actions of calcium and magnesium on the rate of onset of botulinum toxin paralysis of the rat diaphragm. (1967) (35)
- The interaction between divalent cations and botulinum toxin type A in the paralysis of the rat phrenic nerve-hemidiaphragm preparation. (1973) (35)
- Pharmacological experiments on the binding and internalization of the 50,000 dalton carboxyterminus of tetanus toxin at the cholinergic neuromuscular junction. (1985) (33)
- The Neuroparalytic and Hemagglutinating Activities of Botulinum Toxin (1971) (33)
- Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins. (2008) (31)
- Amino acid sequence of a new type of toxic phospholipase A2 from the venom of the Australian tiger snake (Notechis scutatus scutatus). (1995) (31)
- Fragment C of tetanus toxin antagonizes the neuromuscular blocking properties of native tetanus toxin. (1984) (30)
- Drug treatment of mental disorders (1976) (30)
- Blood pressure and heart rate responses evoked by d- and l-amphetamine in the pithed rat preparation. (1975) (30)
- Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule. (2010) (27)
- The Role of Systemic Handling in the Pathophysiologic Actions of Botulinum Toxin (2008) (27)
- Botulinum toxin as a carrier for oral vaccines (1999) (27)
- Localization of the sites and characterization of the mechanisms by which anti-light chain antibodies neutralize the actions of the botulinum holotoxin. (2009) (27)
- Training guidelines for the use of botulinum toxin for the treatment of neurologic disorders (1994) (27)
- Immunologic characterization of spasmodic dysphonia patients who develop resistance to botulinum toxin. (2003) (26)
- Ionic requirements for the neuromuscular blocking action of botulinum toxin: implications with regard to synaptic transmission. (1971) (26)
- The role of acetylcholine receptors and acetylcholinesterase activity in the development of denervation supersensitivity. (1976) (26)
- Use of pharmacologic antagonists to deduce commonalities of biologic activity among clostridial neurotoxins. (1988) (25)
- Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis. (1995) (24)
- [12] Isolation and characterization of the Botulinum neurotoxins (1988) (24)
- Botulinum Toxin: A Deadly Poison Sheds Its Negative Image (1996) (24)
- Characterization of a vertebrate neuromuscular junction that demonstrates selective resistance to botulinum toxin. (1999) (21)
- Immunization of mice with the non-toxic HC50 domain of botulinum neurotoxin presented by rabies virus particles induces a strong immune response affording protection against high-dose botulinum neurotoxin challenge. (2011) (20)
- Evidence That Botulinum Toxin Receptors on Epithelial Cells and Neuronal Cells Are Not Identical: Implications for Development of a Non-Neurotropic Vaccine (2011) (20)
- The effects of acute and chronic botulinum toxin treatment on receptor number, receptor distribution and tissue sensitivity in rat diaphragm. (1977) (20)
- An analysis of the sympathomimetic activity of 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (TIQ). (1975) (20)
- Analysis of the Mechanisms That Underlie Absorption of Botulinum Toxin by the Inhalation Route (2012) (19)
- Actions of the Clostridium botulinum binary toxin on the structure and function of Y-1 adrenal cells. (1988) (19)
- Identification of the Factors That Govern the Ability of Therapeutic Antibodies to Provide Postchallenge Protection Against Botulinum Toxin: A Model for Assessing Postchallenge Efficacy of Medical Countermeasures against Agents of Bioterrorism and Biological Warfare (2011) (18)
- Tetanus toxin and neuronal membranes: the relationship between binding and toxicity. (1991) (18)
- THE BINDING OF BOTULINUM TOXIN TO MEMBRANE LIPIDS: PHOSPHOLIPIDS AND PROTEOLIPID (1971) (17)
- Mechanism of the adverse interaction between monoamine oxidase inhibitors and amphetamine. (1978) (17)
- Isolation and characterization of the Botulinum neurotoxins. (1988) (16)
- CURRENT CONCEPTS ON THE MECHANISM OF ACTION OF CLOSTRIDIAL NEUROTOXINS (1993) (16)
- Pharmacologic experiments on the interaction between crotoxin and the mammalian neuromuscular junction. (1989) (16)
- Expression of botulinum toxin binding sites in Xenopus oocytes (1997) (16)
- Neuropharmacological characterization of fragment B from tetanus toxin. (1985) (15)
- Failure to Inhibit In Vitro or In Vivo Acetycholinesterase with Botulinum Toxin Type A (1969) (15)
- A human monoclonal antibody that binds serotype A botulinum neurotoxin. (2008) (15)
- Progress toward development of an inhalation vaccine against botulinum toxin (2004) (15)
- The study of clostridial and related toxins. The search for unique mechanisms and common denominators. (1990) (14)
- Botulinum toxin: potent poison, potent medicine. (1999) (14)
- Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor. (2014) (14)
- The role of transglutaminase in the mechanism of action of tetanus toxin. (1994) (14)
- Isolation and characterization of a novel human monoclonal antibody that neutralizes tetanus toxin. (1990) (14)
- Studies on the mechanism of action of botulinum toxin. (1979) (13)
- Modulation of botulinum toxin-induced changes in neuromuscular function with antibodies directed against recombinant polypeptides or fragments (2011) (13)
- Partial characterization of the enzymatic activity associated with the binary toxin (type C2) produced by Clostridium botulinum (1988) (12)
- Botulinum C2 toxin and steroid production in adrenal Y-1 cells: the role of microfilaments in the toxin-induced increase in steroid release. (1992) (12)
- Partial antagonism of experimental botulinal intoxication. (1967) (12)
- A study of the interaction between amphetamine and food deprivation. (1974) (12)
- The effect of behavioral stimulant doses of amphetamine on blood pressure. (1976) (11)
- Motivational and response factors as determinants of the reinforcing value of light onset. (1966) (11)
- Blood pressure and heart rate response evoked by p-hydroxyamphetamine and by p-hydroxynorephedrine II. A quantitative assessment of the role of amphetamine metabolites in acute responses evoked by d-amphetamine. (1980) (11)
- The Use of Neuropoisons in the Study of Cholinergic Transmission (1974) (11)
- Tetanus toxin attenuates the ability of phorbol myristate acetate to mobilize cytosolic protein kinase C in NG-108 cells. (1990) (11)
- Tetanus toxin inhibits neurotensin-induced mobilization of cytosolic protein kinase C activity in NG-108 cells. (1991) (11)
- Electrophysiological manifestations of experimental botulinal intoxication: depression of cortical EEG. (1967) (11)
- Clostridial neurotoxins in the age of molecular medicine. (1994) (11)
- Use of monoclonal antibodies as probes for the structure and biological activity of botulinum neurotoxin. (1990) (11)
- Blood pressure and heart rate responses produced by d-amphetamine: correlation with blood levels of drug. (1978) (11)
- Effects of hunger and thirst on reinforcing properties of light onset and light offset. (1968) (10)
- Enhanced Neutralization Potency of Botulinum Neurotoxin Antibodies Using a Red Blood Cell-Targeting Fusion Protein (2011) (10)
- High-throughput homogeneous immunoassay readily identifies monoclonal antibody to serovariant clostridial neurotoxins. (2007) (10)
- The Role of Exoproteases in Governing Intraneuronal Metabolism of Botulinum Toxin (2005) (9)
- Effects of Intraperitoneally Injected Botulinum Toxin on Rat Cerebral Cortex Levels of Acetylcholine (1968) (9)
- Examination of the possible pathophysiology of the central nervous system during botulinal poisoning. (1968) (8)
- Botulinum toxin type B for treatment of spasmodic dysphonia: a case report. (2002) (8)
- PHARMACOLOGICAL STUDIES ON THE CELLULAR AND SUBCELLULAR EFFECTS OF BOTULINUM TOXIN (1981) (7)
- Balancing the benefits and risks of a botulinum toxin vaccine (2007) (7)
- Recombinant rabies virus particles presenting botulinum neurotoxin antigens elicit a protective humoral response in vivo (2014) (7)
- Presynaptic Actions of Botulinum Toxin and β-Bungarotoxin (1977) (6)
- Botulinum Toxins: Transformation of a Toxin into a Treatment (2005) (6)
- A natural human IgM antibody that neutralizes botulinum neurotoxin in vivo. (2008) (6)
- The effects of lithium and physostigmine on rat brain acetylcholinesterase activity (2004) (6)
- Clinically relevant aspects of the mechanism of action of botulinum neurotoxin (1992) (6)
- A comparison of the abilities of chlorpromazine and molindone to interact adversely with guanethidine. (1976) (5)
- Kinetic studies on the entry of d-amphetamine into the central nervous system: I. Cerebrospinal fluid. (1980) (5)
- The effect of chemical sympathectomy on vascular responses in spontaneously hypertensive rats. (1974) (5)
- RBC Adherence of Immune Complexes Containing Botulinum Toxin Improves Neutralization and Macrophage Uptake (2017) (5)
- Absence of binding by botulinum toxin to isolated synaptosomal membranes. (1971) (4)
- The interaction between 5-hydroxytryptamine and botulinum toxin type A. (1968) (4)
- Possible sites at which 5-hydroxytryptamine may antagonize in vivo neuromuscular paralysis. (1970) (4)
- Chapter 46 – Botulinum Toxin (2009) (4)
- Evidence for the non-specificity of the interaction between 5-hydroxytryptamine and botulinum toxin. (1968) (3)
- Role of protein kinase C in short-term transmission at the mammalian neuromuscular junction. (1992) (3)
- Targeting drugs and toxins to the brain: magic bullets. (1988) (3)
- Epitope characterization of sero-specific monoclonal antibody to Clostridium botulinum neurotoxin type A. (2011) (3)
- Mechanism of the antagonism by 5-hydroxytryptamine of the toxicity due to certain cholinergic blocking agents. (1971) (3)
- Blood pressure and heart rate responses evoked by p-hydroxyamphetamine and by p-hydroxynorephedrine. I. The relationship between evoked responses and plasma levels of drug. (1979) (3)
- Poisons of Plant Origin (1974) (3)
- Chimeric Molecules Constructed with Endogenous Substances (1994) (3)
- ANIMALS AND ANIMAL TISSUES IN THE DISCIPLINE OF PHARMACOLOGY * (1983) (2)
- The structure and mechanism of action of botulinum toxin (1996) (2)
- Evidence that there are subcellular pools of norepinephrine and that there is flux of norepinephrine between these pools. (1980) (2)
- Neuropoisons: Their Pathophysiological Actions (2012) (2)
- The effects of behaviorally relevant doses of chlorpromazine and molindone on cardiac adenylate cyclase and on myocardial contractility (1977) (1)
- The Role of the Clostridium botulinum C2 Toxin as a Research Tool to Study Eucaryotic Cell Biology (2008) (1)
- Effect of clostridium botulinum toxin a on pregnant human myometrial contractility in vitro (2005) (1)
- Poisons of animal origin (1971) (1)
- Combined use of molindone and guanethidine in patients with schizophrenia and hypertension. (1979) (1)
- Botulinum Toxin as a Tool in Neurobiology (1992) (1)
- Disulfide bond reduction inhibits norepinephrine accumulation in postganglionic sympathetic nerve endings. (1982) (1)
- Tachyphylaxis to d-amphetamine: a reexamination of the phenomenon. (1978) (1)
- Neuropharmacological Characterization of Botulinum Neurotoxin (1994) (0)
- Recombinant antibody potently neutralizes types A, B, and E botulinum neurotoxins by a clearance-driven mechanism (2008) (0)
- Book Review:Mechanisms of Actions of Neurotoxic Substances. Kedar N. Prasad, Antonia Vernadakis (1983) (0)
- TREATMENT OF CEREBRAL PALSY (2017) (0)
- Actions of botulinum toxin on the human brain and human neuromuscular junction (1995) (0)
- Tetanus Toxin and Protein Kinase C (1993) (0)
- A Brief Guide to the Safe Handling of Biological Toxins (2008) (0)
- The Mammalian Neuromuscular Junction as a Target Tissue for Protein Toxins that Block Exocytosis (1993) (0)
- Influence of the different genetic parameters and regulatory sequences on recombinant expression on a monoclonal antibody (2008) (0)
- Comments on the letter to the editor by Montecucco (1987) (0)
- A Core Facility for the Study of Neurotoxins of Biological Origin (1989) (0)
- Pharmacological Studies on Clostridial Neurotoxins (1982) (0)
- Compositions and methods for systemic administration of oral vaccines and therapeutic agents (1998) (0)
- Therapeutic Approaches to the Treatment of Botulism (1989) (0)
- 589. Repeated Recombinant Adenovirus (rAd) Administration To Generate Mucosal Antibodies (Abs) vs Botulinum Toxin A (BoNT/A) (2006) (0)
- Comment from Coffield, Considine and Simpson (1994) (0)
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